Jeffrey Simms - Publications

Affiliations: 
Ernest Gallo Clinic and Research Center, Emeryville, CA, United States 

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Molecular Cell. 58: 1040-52. PMID 25982113 DOI: 10.1016/j.molcel.2015.04.018  0.64
2015 Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 25801502 DOI: 10.1038/npp.2015.84  0.72
2015 Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery. The Journal of Pharmacology and Experimental Therapeutics. 353: 52-63. PMID 25630467 DOI: 10.1124/jpet.114.220913  0.64
2014 Feduccia AA, Simms JA, Mill D, Yi HY, Bartlett SE. Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens. British Journal of Pharmacology. 171: 3420-31. PMID 24628360 DOI: 10.1111/bph.12690  0.72
2014 Harris NJ, Findlay HE, Simms J, Liu X, Booth PJ. Relative domain folding and stability of a membrane transport protein. Journal of Molecular Biology. 426: 1812-25. PMID 24530957 DOI: 10.1016/j.jmb.2014.01.012  0.64
2014 Simms JA, Nielsen CK, Li R, Bartlett SE. Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395. Addiction Biology. 19: 606-11. PMID 23362976 DOI: 10.1111/adb.12024  0.72
2014 Landgren S, Simms JA, Thelle DS, Strandhagen E, Bartlett SE, Engel JA, Jerlhag E. Correction: The ghrelin signalling system is involved in the consumption of sweets (PLoS ONE) Plos One. 9. DOI: 10.1371/annotation/69c18638-12de-4f08-9a3c-f8c7bf3a0cc6  0.72
2013 Simms J, Booth PJ. Membrane proteins by accident or design. Current Opinion in Chemical Biology. 17: 976-81. PMID 24466578 DOI: 10.1016/j.cbpa.2013.10.005  0.64
2013 Mill DJ, Bito-Onon JJ, Simms JA, Li R, Bartlett SE. Fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm. Plos One. 8: e79824. PMID 24244567 DOI: 10.1371/journal.pone.0079824  0.72
2013 Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nature Neuroscience. 16: 1094-100. PMID 23817545 DOI: 10.1038/nn.3445  0.72
2013 Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM. Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations. Proceedings of the National Academy of Sciences of the United States of America. 110: 5211-6. PMID 23479653 DOI: 10.1073/pnas.1221585110  0.64
2012 Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. Plos One. 7: e44726. PMID 23028593 DOI: 10.1371/journal.pone.0044726  0.72
2012 Feduccia AA, Wang Y, Simms JA, Yi HY, Li R, Bjeldanes L, Ye C, Bartlett SE. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacology, Biochemistry, and Behavior. 102: 241-8. PMID 22579816 DOI: 10.1016/j.pbb.2012.04.014  0.72
2012 Nielsen CK, Simms JA, Li R, Mill D, Yi H, Feduccia AA, Santos N, Bartlett SE. δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4540-52. PMID 22457501 DOI: 10.1523/JNEUROSCI.5345-11.2012  0.72
2012 Sexton PM, Poyner DR, Simms J, Christopoulos A, Hay DL. RAMPs as drug targets. Advances in Experimental Medicine and Biology. 744: 61-74. PMID 22434108 DOI: 10.1007/978-1-4614-2364-5_6  0.64
2012 Barwell J, Wootten D, Simms J, Hay DL, Poyner DR. RAMPs and CGRP receptors. Advances in Experimental Medicine and Biology. 744: 13-24. PMID 22434104 DOI: 10.1007/978-1-4614-2364-5_2  0.64
2012 Leach K, Simms J, Sexton PM, Christopoulos A. Structure-function studies of muscarinic acetylcholine receptors. Handbook of Experimental Pharmacology. 29-48. PMID 22222693 DOI: 10.1007/978-3-642-23274-9_2  0.64
2012 Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation. The Journal of Biological Chemistry. 287: 3642-58. PMID 22147710 DOI: 10.1074/jbc.M111.309328  0.64
2012 Koole C, Wootten D, Simms J, Savage EE, Miller LJ, Christopoulos A, Sexton PM. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. The Journal of Biological Chemistry. 287: 3659-73. PMID 22147709 DOI: 10.1074/jbc.M111.309369  0.64
2012 Simms JA, Haass-Koffler CL, Bito-Onon J, Li R, Bartlett SE. Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 906-18. PMID 22048462 DOI: 10.1038/npp.2011.268  0.72
2012 Wheatley M, Wootten D, Conner MT, Simms J, Kendrick R, Logan RT, Poyner DR, Barwell J. Lifting the lid on GPCRs: the role of extracellular loops. British Journal of Pharmacology. 165: 1688-703. PMID 21864311 DOI: 10.1111/j.1476-5381.2011.01629.x  0.64
2012 Nielsen CK, Simms JA, Bito-Onon JJ, Li R, Ananthan S, Bartlett SE. The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addiction Biology. 17: 224-34. PMID 21309957 DOI: 10.1111/j.1369-1600.2010.00295.x  0.72
2012 Landgren S, Simms JA, Hyytiä P, Engel JA, Bartlett SE, Jerlhag E. Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addiction Biology. 17: 86-94. PMID 21309944 DOI: 10.1111/j.1369-1600.2010.00280.x  0.72
2012 Koole C, Wootten D, Simms J, Valant C, Miller LJ, Christopoulos A, Sexton PM. Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: Allosteric rescue of loss of function mutation (Molecular Pharmacology (2011) 80, (486-497)) Molecular Pharmacology. 82: 142. DOI: 10.1124/mol.82.1.142  0.64
2011 Simms JA, Richards JK, Mill D, Kanholm I, Holgate JY, Bartlett SE. Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the α-2 adrenoreceptor antagonist yohimbine. Psychopharmacology. 218: 101-10. PMID 21863233 DOI: 10.1007/s00213-011-2451-9  0.72
2011 Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R. Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (London, England : 1993). 19: 1108-26. PMID 21827947 DOI: 10.1016/j.str.2011.05.012  0.64
2011 Koole C, Wootten D, Simms J, Valant C, Miller LJ, Christopoulos A, Sexton PM. Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation. Molecular Pharmacology. 80: 486-97. PMID 21616920 DOI: 10.1124/mol.111.072884  0.64
2011 Landgren S, Simms JA, Thelle DS, Strandhagen E, Bartlett SE, Engel JA, Jerlhag E. The ghrelin signalling system is involved in the consumption of sweets. Plos One. 6: e18170. PMID 21448464 DOI: 10.1371/journal.pone.0018170  0.72
2011 Bito-Onon JJ, Simms JA, Chatterjee S, Holgate J, Bartlett SE. Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats. Addiction Biology. 16: 440-9. PMID 21392178 DOI: 10.1111/j.1369-1600.2010.00309.x  0.72
2011 Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biological Psychiatry. 69: 618-24. PMID 21195386 DOI: 10.1016/j.biopsych.2010.11.011  0.72
2011 Wootten DL, Simms J, Massoura AJ, Trim JE, Wheatley M. Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor. Molecular and Cellular Endocrinology. 333: 20-7. PMID 21130837 DOI: 10.1016/j.mce.2010.11.029  0.64
2011 Wootten D, Simms J, Koole C, Woodman OL, Summers RJ, Christopoulos A, Sexton PM. Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. The Journal of Pharmacology and Experimental Therapeutics. 336: 540-50. PMID 21075839 DOI: 10.1124/jpet.110.176362  0.64
2011 Chatterjee S, Steensland P, Simms JA, Holgate J, Coe JW, Hurst RS, Shaffer CL, Lowe J, Rollema H, Bartlett SE. Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 603-15. PMID 21048701 DOI: 10.1038/npp.2010.191  0.72
2010 Steensland P, Simms JA, Nielsen CK, Holgate J, Bito-Onon JJ, Bartlett SE. The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol. Plos One. 5. PMID 20824145 DOI: 10.1371/journal.pone.0012527  0.72
2010 Wootten DL, Simms J, Hay DL, Christopoulos A, Sexton PM. Receptor activity modifying proteins and their potential as drug targets. Progress in Molecular Biology and Translational Science. 91: 53-79. PMID 20691959 DOI: 10.1016/S1877-1173(10)91003-X  0.64
2010 Chugunov AO, Simms J, Poyner DR, Dehouck Y, Rooman M, Gilis D, Langer I. Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation. Molecular Pharmacology. 78: 394-401. PMID 20573782 DOI: 10.1124/mol.110.063578  0.64
2010 Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, Sexton PM. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Molecular Pharmacology. 78: 456-65. PMID 20547734 DOI: 10.1124/mol.110.065664  0.64
2010 Simms JA, Bito-Onon JJ, Chatterjee S, Bartlett SE. Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1453-63. PMID 20200505 DOI: 10.1038/npp.2010.15  0.72
2010 Qi T, Simms J, Bailey RJ, Wheatley M, Rathbone DL, Hay DL, Poyner DR. Structure-function analysis of RAMP1-RAMP3 chimeras. Biochemistry. 49: 522-31. PMID 20017504 DOI: 10.1021/bi9019093  0.64
2010 Just R, Simms J, Furness SGB, Christopoulos A, Sexton PM. Understanding amylin Receptors The Calcitonin Gene-Related Peptide Family: Form, Function and Future Perspectives. 41-57. DOI: 10.1007/978-90-481-2909-6_3  0.64
2010 Simms J. Homology Modelling of G Protein-Coupled Receptors G Protein-Coupled Receptors: Essential Methods. 251-273. DOI: 10.1002/9780470749210.ch13  0.64
2010 Gregory KJ, Valant C, Simms J, Sexton PM, Christopoulos A. The Emergence of Allosteric Modulators for G Protein-Coupled Receptors Gpcr Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. 61-87. DOI: 10.1002/9780470627327.ch3  0.64
2009 Harikumar KG, Simms J, Christopoulos G, Sexton PM, Miller LJ. Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. Biochemistry. 48: 11773-85. PMID 19886671 DOI: 10.1021/bi901326k  0.64
2009 Simms J, Hall NE, Lam PH, Miller LJ, Christopoulos A, Abagyan R, Sexton PM. Homology modeling of GPCRs. Methods in Molecular Biology (Clifton, N.J.). 552: 97-113. PMID 19513644 DOI: 10.1007/978-1-60327-317-6_7  0.64
2009 Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U. Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 137: 949-60. PMID 19464045 DOI: 10.1016/j.cell.2009.03.020  0.72
2009 Richards JK, Simms JA, Bartlett SE. Conditioned cues and yohimbine induce reinstatement of beer and near-beer seeking in Long-Evans rats. Addiction Biology. 14: 144-51. PMID 19076928 DOI: 10.1111/j.1369-1600.2008.00139.x  0.72
2009 Simms J, Hay DL, Bailey RJ, Konycheva G, Bailey G, Wheatley M, Poyner DR. Structure-function analysis of RAMP1 by alanine mutagenesis. Biochemistry. 48: 198-205. PMID 19072332 DOI: 10.1021/bi801869n  0.64
2008 Nielsen CK, Simms JA, Pierson HB, Li R, Saini SK, Ananthan S, Bartlett SE. A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats. Biological Psychiatry. 64: 974-81. PMID 18774553 DOI: 10.1016/j.biopsych.2008.07.018  0.72
2008 Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, Bartlett SE. Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcoholism, Clinical and Experimental Research. 32: 1816-23. PMID 18671810 DOI: 10.1111/j.1530-0277.2008.00753.x  0.72
2008 Richards JK, Simms JA, Steensland P, Taha SA, Borgland SL, Bonci A, Bartlett SE. Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology. 199: 109-17. PMID 18470506 DOI: 10.1007/s00213-008-1136-5  0.72
2007 Conner AC, Simms J, Barwell J, Wheatley M, Poyner DR. Ligand binding and activation of the CGRP receptor. Biochemical Society Transactions. 35: 729-32. PMID 17635135 DOI: 10.1042/BST0350729  0.64
2007 Wheatley M, Simms J, Hawtin SR, Wesley VJ, Wootten D, Conner M, Lawson Z, Conner AC, Baker A, Cashmore Y, Kendrick R, Parslow RA. Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors. Biochemical Society Transactions. 35: 717-20. PMID 17635132 DOI: 10.1042/BST0350717  0.64
2007 Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proceedings of the National Academy of Sciences of the United States of America. 104: 12518-23. PMID 17626178 DOI: 10.1073/pnas.0705368104  0.72
2007 Dayas CV, Liu X, Simms JA, Weiss F. Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone. Biological Psychiatry. 61: 979-89. PMID 17098214 DOI: 10.1016/j.biopsych.2006.07.034  0.72
2006 Conner AC, Simms J, Conner MT, Wootten DL, Wheatley M, Poyner DR. Diverse functional motifs within the three intracellular loops of the CGRP1 receptor. Biochemistry. 45: 12976-85. PMID 17059214 DOI: 10.1021/bi0615801  0.64
2003 Hawtin SR, Wesley VJ, Simms J, Parslow RA, Miles A, McEwan K, Keen M, Wheatley M. An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist. European Journal of Biochemistry / Febs. 270: 4681-8. PMID 14622255 DOI: 10.1046/j.1432-1033.2003.03865.x  0.64
2003 Wheatley M, Hawtin SR, Wesley VJ, Howard HC, Simms J, Miles A, McEwan K, Parslow RA. Agonist binding to peptide hormone receptors. Biochemical Society Transactions. 31: 35-9. PMID 12546649 DOI: 10.1042/  0.64
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