Rudolph E. Tanzi, PhD, Harvard University - Related publications

Neurology Harvard Medical School, Boston, MA, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Rosas-Hernandez H, Cuevas E, Raymick JB, Robinson BL, Ali SF, Hanig J, Sarkar S. Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer's Disease. Current Alzheimer Research. PMID 30907317 DOI: 10.2174/1567205016666190321155422   
2019 Dourlen P, Kilinc D, Malmanche N, Chapuis J, Lambert JC. The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis? Acta Neuropathologica. PMID 30982098 DOI: 10.1007/s00401-019-02004-0   
2019 Fitz NF, Nam KN, Koldamova R, Lefterov I. Therapeutic Targeting of Nuclear Receptors, LXR and RXR, for Alzheimer's Disease. British Journal of Pharmacology. PMID 30924124 DOI: 10.1111/bph.14668   
2019 Ştefănescu R, Stanciu GD, Luca A, Caba IC, Tamba BI, Mihai CT. Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer's Disease. Molecules (Basel, Switzerland). 24. PMID 30909659 DOI: 10.3390/molecules24061167   
2019 Yu L, Petyuk VA, Tasaki S, Boyle PA, Gaiteri C, Schneider JA, De Jager PL, Bennett DA. Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease. Jama Neurology. PMID 31009033 DOI: 10.1001/jamaneurol.2019.0834   
2019 Quitterer U, AbdAlla S. Improvements of Symptoms of Alzheimer`s Disease by Inhibition of the Angiotensin System. Pharmacological Research. PMID 30991105 DOI: 10.1016/j.phrs.2019.04.014   
2019 Egan MF, Kost J, Voss T, Mukai Y, Aisen PS, Cummings JL, Tariot PN, Vellas B, van Dyck CH, Boada M, Zhang Y, Li W, Furtek C, Mahoney E, Harper Mozley L, et al. Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease. The New England Journal of Medicine. 380: 1408-1420. PMID 30970186 DOI: 10.1056/NEJMoa1812840   
2019 Lin Y, Liang X, Yao Y, Xiao H, Shi Y, Yang J. Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p. Life Sciences. PMID 30951743 DOI: 10.1016/j.lfs.2019.04.004   
2019 Startin CM, Ashton NJ, Hamburg S, Hithersay R, Wiseman FK, Mok KY, Hardy J, Lleó A, Lovestone S, Parnetti L, Zetterberg H, Hye A, , Strydom A. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease. Alzheimer's Research & Therapy. 11: 26. PMID 30902060 DOI: 10.1186/s13195-019-0477-0   
2019 Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 1365. PMID 30911003 DOI: 10.1038/s41467-019-09118-9   
2019 Quevenco FC, Schreiner SJ, Preti MG, van Bergen JMG, Kirchner T, Wyss M, Steininger SC, Gietl A, Leh SE, Buck A, Pruessmann KP, Hock C, Nitsch RM, Henning A, Van De Ville D, et al. GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults. Neuroimage. Clinical. 22: 101776. PMID 30927605 DOI: 10.1016/j.nicl.2019.101776   
2019 Zhou Q, Luo L, Wang X, Li X. Relationship between single nucleotide polymorphisms in the 3'UTR of amyloid precursor protein and risk of Alzheimer's disease and its mechanism. Bioscience Reports. PMID 30914454 DOI: 10.1042/BSR20182485   
2019 Caballero AB, Espargarò A, Pont C, Busquets MA, Estelrich J, Muñoz-Torrero D, Gamez P, Sabate R. Bacterial Inclusion Bodies for Anti-Amyloid Drug Discovery: Current and Future Screening Methods. Current Protein & Peptide Science. PMID 30924417 DOI: 10.2174/1389203720666190329120007   
2019 Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/brain/awz066   
2019 Rabinovici GD, Gatsonis C, Apgar C, Chaudhary K, Gareen I, Hanna L, Hendrix J, Hillner BE, Olson C, Lesman-Segev OH, Romanoff J, Siegel BA, Whitmer RA, Carrillo MC. Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. Jama. 321: 1286-1294. PMID 30938796 DOI: 10.1001/jama.2019.2000   
2019 Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, et al. New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease. Neurobiology of Disease. PMID 30928644 DOI: 10.1016/j.nbd.2019.03.028   
2019 Deshpande P, Gogia N, Singh A. Exploring the efficacy of natural products in alleviating Alzheimer's disease. Neural Regeneration Research. 14: 1321-1329. PMID 30964049 DOI: 10.4103/1673-5374.253509   
2019 Wang F, Chen D, Wu P, Klein C, Jin C. Formaldehyde, Epigenetics and Alzheimer's disease. Chemical Research in Toxicology. PMID 30964647 DOI: 10.1021/acs.chemrestox.9b00090   
2019 Neo Shin N, Jeon H, Jung Y, Baek S, Lee S, Yoo HC, Bae GH, Park K, Yang SH, Han JM, Kim I, Kim Y. Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains. Acs Chemical Neuroscience. PMID 31016960 DOI: 10.1021/acschemneuro.9b00093   
2019 Guo H, Zhao Z, Zhang R, Chen P, Zhang X, Cheng F, Gou X. Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30958361 DOI: 10.3233/JAD-181177   
2019 Oliver DMA, Reddy PH. Molecular Basis of Alzheimer's Disease: Focus on Mitochondria. Journal of Alzheimer's Disease : Jad. PMID 30932888 DOI: 10.3233/JAD-190048   
2019 Choi SI, Lee B, Woo JH, Jeong JB, Jun I, Kim EK. APP processing and metabolism in corneal fibroblasts and epithelium as a potential biomarker for Alzheimer's disease. Experimental Eye Research. PMID 30930125 DOI: 10.1016/j.exer.2019.03.012   
2019 Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, et al. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology. 6: 762-777. PMID 31020001 DOI: 10.1002/acn3.755   
2019 El Hajj H, Savage JC, Bisht K, Parent M, Vallières L, Rivest S, Tremblay MÈ. Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology. Journal of Neuroinflammation. 16: 87. PMID 30992040 DOI: 10.1186/s12974-019-1473-9   
2019 Qin Q, Li Y. Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment. Journal of Medical Virology. PMID 30997676 DOI: 10.1002/jmv.25481   
2019 Zhu L, Gong L, Yang T, Xiao X. Calpastatin Mediates Development of Alzheimer's Disease in Diabetes. Journal of Alzheimer's Disease : Jad. PMID 30909245 DOI: 10.3233/JAD-190004   
2019 Gao G, He J, Luo Y, Sun Y, Zhou Y, Zhang J, Xing Y, Dai J. Axonopathy likely initiates neuropathological processes via a mechanism of axonal leakage in Alzheimer's mouse models. Current Molecular Medicine. PMID 30961496 DOI: 10.2174/1566524019666190405174908   
2019 Vaquer-Alicea J, Diamond MI. Propagation of Protein Aggregation in Neurodegenerative Diseases. Annual Review of Biochemistry. PMID 30917002 DOI: 10.1146/annurev-biochem-061516-045049   
2019 Ahmad SS, Kamal MA. Current updates on the regulation of beta-secretase movement as a potential restorative focus for management of Alzheimer's disease. Protein and Peptide Letters. PMID 30950339 DOI: 10.2174/0929866526666190405125334   
2019 Stern RA, Adler CH, Chen K, Navitsky M, Luo J, Dodick DW, Alosco ML, Tripodis Y, Goradia DD, Martin B, Mastroeni D, Fritts NG, Jarnagin J, Devous MD, Mintun MA, et al. Tau Positron-Emission Tomography in Former National Football League Players. The New England Journal of Medicine. PMID 30969506 DOI: 10.1056/NEJMoa1900757   
2019 Herrera-Rivero M, Santarelli F, Brosseron F, Kummer MP, Heneka MT. Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression. Molecular Neurobiology. PMID 30852796 DOI: 10.1007/s12035-019-1540-3   
2019 Ma G, Liu M, Du K, Zhong X, Gong S, Jiao L, Wei M. Differential Expression of mRNAs in the Brain Tissues of Patients with Alzheimer's Disease Based on GEO Expression Profile and Its Clinical Significance. Biomed Research International. 2019: 8179145. PMID 30918899 DOI: 10.1155/2019/8179145   
2019 Kubankova M, Lin X, Albrecht T, Edel JB, Kuimova MK. Rapid fragmentation during seeded lysozyme aggregation revealed at the single molecule level. Analytical Chemistry. PMID 30999745 DOI: 10.1021/acs.analchem.9b01221   
2019 Rencus-Lazar S, DeRowe Y, Adsi H, Gazit E, Laor D. Yeast Models for the Study of Amyloid-Associated Disorders and Development of Future Therapy. Frontiers in Molecular Biosciences. 6: 15. PMID 30968029 DOI: 10.3389/fmolb.2019.00015   
2019 Boutajangout A, Lindberg H, Awwad A, Paul A, Baitalmal R, Almokyad I, Höidén-Guthenberg I, Gunneriusson E, Frejd FY, Härd T, Löfblom J, Ståhl S, Wisniewski T. Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model. Frontiers in Aging Neuroscience. 11: 64. PMID 30967771 DOI: 10.3389/fnagi.2019.00064   
2019 Chang KL, Wong LR, Pee HN, Yang S, Ho PC. Reverting Metabolic Dysfunction in Cortex and Cerebellum of APP/PS1 Mice, a Model for Alzheimer's Disease by Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Agonist. Molecular Neurobiology. PMID 31016475 DOI: 10.1007/s12035-019-1586-2   
2019 Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K. Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. PMID 31029568 DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.029   
2019 Cao K, Xiang J, Dong YT, Xu Y, Li Y, Song H, Zeng XX, Ran LY, Hong W, Guan ZZ. Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation. Alzheimer's Research & Therapy. 11: 35. PMID 31010414 DOI: 10.1186/s13195-019-0490-3   
2019 Kumar S, Srivastav S, Fatima M, Giri RS, Mandal B, Mondal AC. A Synthetic Pro-Drug Peptide Reverses Amyloid-β-Induced Toxicity in the Rat Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30958369 DOI: 10.3233/JAD-181273   
2019 Teter B, Morihara T, Lim GP, Chu T, Jones MR, Zuo X, Paul RM, Frautschy SA, Cole GM. Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis. Neurobiology of Disease. PMID 30951849 DOI: 10.1016/j.nbd.2019.02.015   
2019 Goudey B, Fung BJ, Schieber C, Faux NG, , . A blood-based signature of cerebrospinal fluid Aβ status. Scientific Reports. 9: 4163. PMID 30853713 DOI: 10.1038/s41598-018-37149-7   
2019 Li K, Luo X, Zeng Q, Huang P, Shen Z, Xu X, Xu J, Wang C, Zhou J, Zhang M, . Gray matter structural covariance networks changes along the Alzheimer's disease continuum. Neuroimage. Clinical. 23: 101828. PMID 31029051 DOI: 10.1016/j.nicl.2019.101828   
2019 Mazumder MK, Choudhury S. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical Hypotheses. 125: 94-99. PMID 30902161 DOI: 10.1016/j.mehy.2019.02.035   
2019 Dionisio-Santos DA, Olschowka JA, O'Banion MK. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease. Journal of Neuroinflammation. 16: 74. PMID 30953557 DOI: 10.1186/s12974-019-1453-0   
2019 Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/j.celrep.2019.03.099   
2019 Armstrong NM, Huang CW, Williams OA, Bilgel M, An Y, Doshi J, Erus G, Davatzikos C, Wong DF, Ferrucci L, Resnick SM. Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults. Neuroimage. Clinical. 22: 101769. PMID 30927602 DOI: 10.1016/j.nicl.2019.101769   
2019 Arber C, Toombs J, Lovejoy CC, Ryan NS, Paterson RW, Willumsen N, Gkanatsiou E, Portelius E, Blennow K, Heslegrave A, Schott JM, Hardy J, Lashley T, Fox NC, Zetterberg H, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Molecular Psychiatry. PMID 30980041 DOI: 10.1038/s41380-019-0410-8   
2019 Takahashi M, Tada T, Nakamura T, Koyama K, Momose T. Efficacy and Limitations of rCBF-SPECT in the Diagnosis of Alzheimer's Disease With Amyloid-PET. American Journal of Alzheimer's Disease and Other Dementias. 1533317519841192. PMID 30966759 DOI: 10.1177/1533317519841192   
2019 Vergallo A, Giampietri L, Pagni C, Giorgi FS, Nicoletti V, Miccoli M, Libertini P, Petrozzi L, Bonuccelli U, Tognoni G. Association Between CSF Beta-Amyloid and Apathy in Early-Stage Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology. 32: 164-169. PMID 30913958 DOI: 10.1177/0891988719838627   
2019 Fang EF. Mitophagy and NAD inhibit Alzheimer disease. Autophagy. 1-3. PMID 30922179 DOI: 10.1080/15548627.2019.1596497