| Year |
Citation |
Score |
| 2024 |
Ullman JC, Mellem KT, Xi Y, Ramanan V, Merritt H, Choy R, Gujral T, Young LEA, Blake K, Tep S, Homburger JR, O'Regan A, Ganesh S, Wong P, Satterfield TF, ... ... Hurley TD, et al. Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. Science Translational Medicine. 16: eadf1691. PMID 38232139 DOI: 10.1126/scitranslmed.adf1691 |
0.655 |
|
| 2022 |
Fastman NM, Liu Y, Ramanan V, Merritt H, Ambing E, DePaoli-Roach AA, Roach PJ, Hurley TD, Mellem KT, Ullman JC, Green E, Morgans D, Tzitzilonis C. The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell Reports. 40: 111041. PMID 35793618 DOI: 10.1016/j.celrep.2022.111041 |
0.706 |
|
| 2021 |
Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, ... ... Hurley TD, et al. Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Cell Metabolism. PMID 34043942 DOI: 10.1016/j.cmet.2021.05.003 |
0.64 |
|
| 2020 |
Tang B, Frasinyuk MS, Chikwana VM, Mahalingan KK, Morgan CA, Segvich DM, Bondarenko SP, Mrug GP, Wyrebek P, Watt DS, DePaoli-Roach AA, Roach PJ, Hurley TD. Discovery and development of small-molecule inhibitors of glycogen synthase. Journal of Medicinal Chemistry. PMID 32134266 DOI: 10.1021/acs.jmedchem.9b01851 |
0.708 |
|
| 2018 |
Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, et al. ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells. Cell Chemical Biology. PMID 30293938 DOI: 10.1016/J.Chembiol.2018.09.005 |
0.32 |
|
| 2017 |
Buchman CD, Hurley TD. Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives. Journal of Medicinal Chemistry. PMID 28219011 DOI: 10.1021/Acs.Jmedchem.6B01825 |
0.369 |
|
| 2016 |
Mahalingan KK, Baskaran S, Depaoli-Roach AA, Roach PJ, Hurley TD. Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation. Biochemistry. PMID 27935293 DOI: 10.1021/Acs.Biochem.6B00884 |
0.787 |
|
| 2016 |
Maile CA, Hingst JR, Mahalingan KK, O'Reilly AO, Cleasby ME, Mickelson JR, McCue ME, Anderson SM, Hurley TD, Wojtaszewski JF, Piercy RJ. A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. Biochimica Et Biophysica Acta. PMID 27592162 DOI: 10.1016/J.Bbagen.2016.08.021 |
0.304 |
|
| 2016 |
Contreras CJ, Segvich DM, Mahalingan K, Chikwana VM, Kirley TL, Hurley TD, DePaoli-Roach AA, Roach PJ. Incorporation of phosphate into glycogen by glycogen synthase. Archives of Biochemistry and Biophysics. PMID 27036853 DOI: 10.1016/J.Abb.2016.03.020 |
0.68 |
|
| 2015 |
Buchman CD, Mahalingan KK, Hurley TD. Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. Chemico-Biological Interactions. 234: 38-44. PMID 25641190 DOI: 10.1016/J.Cbi.2014.12.038 |
0.343 |
|
| 2015 |
Morgan CA, Hurley TD. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. Journal of Medicinal Chemistry. 58: 1964-75. PMID 25634381 DOI: 10.1021/Jm501900S |
0.422 |
|
| 2015 |
Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chemico-Biological Interactions. 234: 18-28. PMID 25512087 DOI: 10.1016/J.Cbi.2014.12.008 |
0.722 |
|
| 2015 |
Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, Benner SA. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences of the United States of America. 112: 458-63. PMID 25453080 DOI: 10.1073/Pnas.1404167111 |
0.332 |
|
| 2015 |
Morgan CA, Hurley TD. Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chemico-Biological Interactions. 234: 29-37. PMID 25450233 DOI: 10.1016/J.Cbi.2014.10.028 |
0.442 |
|
| 2015 |
Chikwana VM, Khanna M, Baskaran S, Tagliabracci VS, Contreras CJ, DePaoli-Roach A, Roach PJ, Hurley TD. Correction: Structural basis for 2′-phosphate incorporation into glycogen by glycogen synthase (Proceedings of the National Academy of Sciences of the United States of America (2013) 110, 52 (20976-20981) DOI: 10.1073/pnas.1310106111) Proceedings of the National Academy of Sciences of the United States of America. 112: E2264. DOI: 10.1073/Pnas.1506041112 |
0.728 |
|
| 2014 |
Wang B, Buchman CD, Li L, Hurley TD, Meroueh SO. Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2. Journal of Chemical Information and Modeling. 54: 2105-16. PMID 24856086 DOI: 10.1021/Ci5002026 |
0.357 |
|
| 2014 |
Parajuli B, Georgiadis TM, Fishel ML, Hurley TD. Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. Chembiochem : a European Journal of Chemical Biology. 15: 701-12. PMID 24677340 DOI: 10.1002/Cbic.201300625 |
0.706 |
|
| 2014 |
Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22. PMID 24444054 DOI: 10.1021/Jm401377V |
0.731 |
|
| 2014 |
Parajuli B, Fishel ML, Hurley TD. Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. Journal of Medicinal Chemistry. 57: 449-61. PMID 24387105 DOI: 10.1021/Jm401508P |
0.721 |
|
| 2014 |
Donovan EL, Kimble-Hill AC, Hurley TD, Wells CD. Toward Understanding the Role of Amot80 Lipid Binding in Cellular Proliferation and Migration Biophysical Journal. 106: 303a. DOI: 10.1016/J.Bpj.2013.11.1761 |
0.305 |
|
| 2013 |
Chikwana VM, Khanna M, Baskaran S, Tagliabracci VS, Contreras CJ, DePaoli-Roach A, Roach PJ, Hurley TD. Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 110: 20976-81. PMID 24324135 DOI: 10.1073/Pnas.1310106111 |
0.76 |
|
| 2013 |
Akin BL, Hurley TD, Chen Z, Jones LR. The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. The Journal of Biological Chemistry. 288: 30181-91. PMID 23996003 DOI: 10.1074/Jbc.M113.501585 |
0.314 |
|
| 2013 |
Khanna M, Imasaki T, Chikwana VM, Perez-Miller S, Hunter GO, Mosley A, Takagi Y, Hurley TD. Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells. Protein Expression and Purification. 90: 78-83. PMID 23711380 DOI: 10.1016/J.Pep.2013.05.007 |
0.702 |
|
| 2013 |
González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD. Catalytic contribution of threonine 244 in human ALDH2. Chemico-Biological Interactions. 202: 32-40. PMID 23295226 DOI: 10.1016/J.Cbi.2012.12.009 |
0.758 |
|
| 2012 |
Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacological Reviews. 64: 520-39. PMID 22544865 DOI: 10.1124/Pr.111.005538 |
0.428 |
|
| 2012 |
Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. The Biochemical Journal. 441: 763-87. PMID 22248338 DOI: 10.1042/Bj20111416 |
0.696 |
|
| 2011 |
Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. The Journal of Biological Chemistry. 286: 43486-94. PMID 22021038 DOI: 10.1074/Jbc.M111.293597 |
0.803 |
|
| 2011 |
Baskaran S, Chikwana VM, Contreras CJ, Davis KD, Wilson WA, DePaoli-Roach AA, Roach PJ, Hurley TD. Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. The Journal of Biological Chemistry. 286: 33999-4006. PMID 21835915 DOI: 10.1074/Jbc.M111.264531 |
0.757 |
|
| 2011 |
Liu JY, Hurley TD. A new crystal form of mouse thiamin pyrophosphokinase. International Journal of Biochemistry and Molecular Biology. 2: 111-8. PMID 21552434 |
0.32 |
|
| 2011 |
Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ. Phosphate incorporation during glycogen synthesis and Lafora disease. Cell Metabolism. 13: 274-82. PMID 21356517 DOI: 10.1016/J.Cmet.2011.01.017 |
0.699 |
|
| 2011 |
Parajuli B, Kimble-Hill AC, Khanna M, Ivanova Y, Meroueh S, Hurley TD. Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. Chemico-Biological Interactions. 191: 153-8. PMID 21349255 DOI: 10.1016/J.Cbi.2011.02.018 |
0.714 |
|
| 2011 |
Kimble-Hill AC, Younus H, Meroueh S, Hurley TD. Structure Based Inhibition of Mitochondrial Aldehyde Dehydrogenase (ALDH2) Activity Biophysical Journal. 100: 215a. DOI: 10.1016/J.Bpj.2010.12.1387 |
0.394 |
|
| 2010 |
Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, Doorn JA. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition. Chemical Research in Toxicology. 23: 1843-50. PMID 20954713 DOI: 10.1021/Tx100317Q |
0.421 |
|
| 2010 |
Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD. Structural basis for glucose-6-phosphate activation of glycogen synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 17563-8. PMID 20876143 DOI: 10.1073/Pnas.1006340107 |
0.779 |
|
| 2010 |
Perez-Miller S, Zou Q, Novotny MV, Hurley TD. High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones. Protein Science : a Publication of the Protein Society. 19: 1469-79. PMID 20509168 DOI: 10.1002/Pro.426 |
0.697 |
|
| 2010 |
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Structural & Molecular Biology. 17: 159-64. PMID 20062057 DOI: 10.1038/Nsmb.1737 |
0.752 |
|
| 2009 |
Aneetha H, O'Dell DK, Tan B, Walker JM, Hurley TD. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. Bioorganic & Medicinal Chemistry Letters. 19: 237-41. PMID 19013794 DOI: 10.1016/J.Bmcl.2008.10.087 |
0.342 |
|
| 2008 |
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (New York, N.Y.). 321: 1493-5. PMID 18787169 DOI: 10.1126/Science.1158554 |
0.322 |
|
| 2008 |
Wang WL, Chai SC, Huang M, He HZ, Hurley TD, Ye QZ. Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity. Journal of Medicinal Chemistry. 51: 6110-20. PMID 18785729 DOI: 10.1021/Jm8005788 |
0.332 |
|
| 2007 |
Ma ZQ, Xie SX, Huang QQ, Nan FJ, Hurley TD, Ye QZ. Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes. Bmc Structural Biology. 7: 84. PMID 18093325 DOI: 10.1186/1472-6807-7-84 |
0.397 |
|
| 2007 |
González-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 46: 14075-86. PMID 18020427 DOI: 10.1021/Bi701023Z |
0.446 |
|
| 2007 |
Janecki DJ, Bemis KG, Tegeler TJ, Sanghani PC, Zhai L, Hurley TD, Bosron WF, Wang M. A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme. Analytical Biochemistry. 369: 18-26. PMID 17692277 DOI: 10.1016/J.Ab.2007.06.043 |
0.603 |
|
| 2007 |
Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA. Structural basis for regulation of protein phosphatase 1 by inhibitor-2. The Journal of Biological Chemistry. 282: 28874-83. PMID 17636256 DOI: 10.1074/Jbc.M703472200 |
0.654 |
|
| 2007 |
Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. The Journal of Biological Chemistry. 282: 12940-50. PMID 17327228 DOI: 10.1074/Jbc.M607959200 |
0.822 |
|
| 2007 |
Florang VR, Rees JN, Brogden NK, Anderson DG, Hurley TD, Doorn JA. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. Neurotoxicology. 28: 76-82. PMID 16956664 DOI: 10.1016/J.Neuro.2006.07.018 |
0.318 |
|
| 2006 |
Hurley TD, Walls C, Bennett JR, Roach PJ, Wang M. Direct detection of glycogenin reaction products during glycogen initiation. Biochemical and Biophysical Research Communications. 348: 374-8. PMID 16889748 DOI: 10.1016/J.Bbrc.2006.07.106 |
0.548 |
|
| 2006 |
Ho KK, Hurley TD, Weiner H. Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis. Biochemistry. 45: 9445-53. PMID 16878979 DOI: 10.1021/Bi060718C |
0.388 |
|
| 2006 |
Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chemical Research in Toxicology. 19: 102-10. PMID 16411662 DOI: 10.1021/Tx0501839 |
0.439 |
|
| 2006 |
Liu JY, Timm DE, Hurley TD. Pyrithiamine as a substrate for thiamine pyrophosphokinase. The Journal of Biological Chemistry. 281: 6601-7. PMID 16365036 DOI: 10.1074/Jbc.M510951200 |
0.443 |
|
| 2005 |
Larson HN, Weiner H, Hurley TD. Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant. The Journal of Biological Chemistry. 280: 30550-6. PMID 15983043 DOI: 10.1074/Jbc.M502345200 |
0.82 |
|
| 2005 |
Ho KK, Allali-Hassani A, Hurley TD, Weiner H. Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. Biochemistry. 44: 8022-9. PMID 15924421 DOI: 10.1021/Bi050038U |
0.303 |
|
| 2005 |
Hurley TD, Stout S, Miner E, Zhou J, Roach PJ. Requirements for catalysis in mammalian glycogenin. The Journal of Biological Chemistry. 280: 23892-9. PMID 15849187 DOI: 10.1074/Jbc.M502344200 |
0.635 |
|
| 2005 |
Quinney SK, Sanghani SP, Davis WI, Hurley TD, Sun Z, Murry DJ, Bosron WF. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. The Journal of Pharmacology and Experimental Therapeutics. 313: 1011-6. PMID 15687373 DOI: 10.1124/Jpet.104.081265 |
0.716 |
|
| 2004 |
Gibbons BJ, Hurley TD. Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry. 43: 12555-62. PMID 15449945 DOI: 10.1021/Bi0489107 |
0.695 |
|
| 2004 |
Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF. Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. The Journal of Pharmacology and Experimental Therapeutics. 310: 469-76. PMID 15082749 DOI: 10.1124/Jpet.104.067116 |
0.701 |
|
| 2003 |
Perez-Miller SJ, Hurley TD. Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Biochemistry. 42: 7100-9. PMID 12795606 DOI: 10.1021/Bi034182W |
0.764 |
|
| 2003 |
Sanghani PC, Robinson H, Bennett-Lovsey R, Hurley TD, Bosron WF. Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase). Chemico-Biological Interactions. 143: 195-200. PMID 12604204 DOI: 10.1016/S0009-2797(02)00203-X |
0.664 |
|
| 2002 |
Sanghani PC, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. Biochemistry. 41: 15189-94. PMID 12484756 DOI: 10.1021/Bi026705Q |
0.676 |
|
| 2002 |
Sanghani PC, Robinson H, Bosron WF, Hurley TD. Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry. 41: 10778-86. PMID 12196016 DOI: 10.1021/Bi0257639 |
0.698 |
|
| 2002 |
Gibbons BJ, Roach PJ, Hurley TD. Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin. Journal of Molecular Biology. 319: 463-77. PMID 12051921 DOI: 10.1016/S0022-2836(02)00305-4 |
0.756 |
|
| 2002 |
Hammen PK, Allali-Hassani A, Hallenga K, Hurley TD, Weiner H. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase. Biochemistry. 41: 7156-68. PMID 12033950 DOI: 10.1021/Bi012197T |
0.431 |
|
| 2002 |
Bosron WF, Hurley TD. Lessons from a bacterial cocaine esterase. Nature Structural Biology. 9: 4-5. PMID 11753424 DOI: 10.1038/Nsb0102-4 |
0.578 |
|
| 2001 |
Hurley TD, Perez-Miller S, Breen H. Order and disorder in mitochondrial aldehyde dehydrogenase Chemico-Biological Interactions. 130: 3-14. PMID 11306026 DOI: 10.1016/S0009-2797(00)00217-9 |
0.755 |
|
| 2001 |
Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD. Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Science : a Publication of the Protein Society. 10: 697-706. PMID 11274460 DOI: 10.1110/Ps.45001 |
0.817 |
|
| 2000 |
Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF. Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase Biochemistry. 39: 10720-10729. PMID 10978156 DOI: 10.1021/Bi9929711 |
0.696 |
|
| 2000 |
Wei B, Ni L, Hurley TD, Weiner H. Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase Biochemistry. 39: 5295-5302. PMID 10819999 DOI: 10.1021/Bi000028N |
0.443 |
|
| 2000 |
Yang J, Hurley TD, DePaoli-Roach AA. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase: Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif Journal of Biological Chemistry. 275: 22635-22644. PMID 10807923 DOI: 10.1074/Jbc.M003082200 |
0.616 |
|
| 1999 |
Ni L, Zhou J, Hurley TD, Weiner H. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Science : a Publication of the Protein Society. 8: 2784-90. PMID 10631996 DOI: 10.1110/Ps.8.12.2784 |
0.443 |
|
| 1999 |
Xie PT, Hurley TD. Methionine-141 directly influences the binding of 4-methylpyrazole in human σσ alcohol dehydrogenase Protein Science. 8: 2639-2644. PMID 10631979 DOI: 10.1110/Ps.8.12.2639 |
0.499 |
|
| 1999 |
Hurley TD, Weiner H. Evaluation of the roles of the conserved residues of aldehyde dehydrogenase Advances in Experimental Medicine and Biology. 463: 45-52. PMID 10352668 DOI: 10.1007/978-1-4615-4735-8_6 |
0.402 |
|
| 1999 |
Hurley TD, Steinmetz CG, Weiner H. Three-dimensional structure of mitochondrial aldehyde dehydrogenase: Mechanistic implications Advances in Experimental Medicine and Biology. 463: 15-25. PMID 10352665 DOI: 10.1007/978-1-4615-4735-8_3 |
0.457 |
|
| 1999 |
Stone CL, Jipping MB, Owusu-Dekyi K, Hurley TD, Li TK, Bosron WF. The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver β3β3 alcohol dehydrogenase Biochemistry. 38: 5829-5835. PMID 10231534 DOI: 10.1021/Bi982944V |
0.662 |
|
| 1998 |
Longenecker KL, Roach PJ, Hurley TD. Crystallographic studies of casein kinase I δ: Toward a structural understanding of auto-inhibition Acta Crystallographica Section D: Biological Crystallography. 54: 473-475. PMID 9761932 DOI: 10.1107/S0907444997011724 |
0.554 |
|
| 1997 |
Harris RA, Hawes JW, Popov KM, Zhao Y, Shimomura Y, Sato J, Jaskiewicz J, Hurley TD. Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases Advances in Enzyme Regulation. 37: 271-293. PMID 9381974 DOI: 10.1016/S0065-2571(96)00009-X |
0.404 |
|
| 1997 |
Sheikh S, Ni L, Hurley TD, Weiner H. The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase Journal of Biological Chemistry. 272: 18817-18822. PMID 9228056 DOI: 10.1074/Jbc.272.30.18817 |
0.422 |
|
| 1997 |
Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD. X-ray structure of human class IV σσ alcohol dehydrogenase. Structural basis for substrate specificity Journal of Biological Chemistry. 272: 18558-18563. PMID 9228021 DOI: 10.1074/Jbc.272.30.18558 |
0.71 |
|
| 1997 |
Steinmetz CG, Xie P, Weiner H, Hurley TD. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion Structure. 5: 701-711. PMID 9195888 DOI: 10.1016/S0969-2126(97)00224-4 |
0.504 |
|
| 1997 |
Hurley TD, Steinmetz CG, Xie P, Yang ZN. Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity Advances in Experimental Medicine and Biology. 414: 291-302. PMID 9059633 DOI: 10.1007/978-1-4615-5871-2_34 |
0.379 |
|
| 1997 |
Kedishvili NY, Gough WH, Chernoff EA, Hurley TD, Stone CL, Bowman KD, Popov KM, Bosron WF, Li TK. cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids. The Journal of Biological Chemistry. 272: 7494-500. PMID 9054452 DOI: 10.1074/Jbc.272.11.7494 |
0.652 |
|
| 1997 |
Yang ZN, Bosron WF, Hurley TD. Structure of human χχ alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase Journal of Molecular Biology. 265: 330-343. PMID 9018047 DOI: 10.1006/Jmbi.1996.0731 |
0.694 |
|
| 1996 |
Davis GJ, Bosron WF, Stone CL, Owusu-Dekyi K, Hurley TD. X-ray structure of human β3β3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding Journal of Biological Chemistry. 271: 17057-17061. PMID 8663387 DOI: 10.1074/Jbc.271.29.17057 |
0.627 |
|
| 1996 |
Longenecker KL, Roach PJ, Hurley TD. Three-dimensional structure of mammalian casein kinase I: Molecular basis for phosphate recognition Journal of Molecular Biology. 257: 618-631. PMID 8648628 DOI: 10.1006/Jmbi.1996.0189 |
0.602 |
|
| 1995 |
Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li TK. Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymes Journal of Biological Chemistry. 270: 3625-3630. PMID 7876099 DOI: 10.1074/Jbc.270.8.3625 |
0.688 |
|
| 1995 |
Stone CL, Hurley TD, Peggs CF, Kedishvili NY, Davis GJ, Thomasson HR, Li TK, Bosron WF. Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: Identification of inhibitor complexes by kinetics and molecular modeling Biochemistry. 34: 4008-4014. PMID 7696266 DOI: 10.1021/Bi00012A019 |
0.662 |
|
| 1995 |
Kedishvili NY, Bosron WF, Stone CL, Peggs CF, Thomasson HR, Popov KM, Carr LG, Hurley TD, Edenberg HJ, Li TK. Cloning and expression of a human stomach alcohol dehydrogenase isozyme Advances in Experimental Medicine and Biology. 372: 341-347. PMID 7484396 DOI: 10.1007/978-1-4615-1965-2_41 |
0.609 |
|
| 1995 |
Hurley TD, Vessell DL. The role of leucine 116 in determining substrate specificity in human B1 alcohol dehydrogenase Advances in Experimental Medicine and Biology. 372: 321-325. PMID 7484393 DOI: 10.1007/978-1-4615-1965-2_38 |
0.353 |
|
| 1994 |
Davis GJ, Carr LG, Hurley TD, Li TK, Bosron WF. Comparative Roles of Histidine-51 in Human β1β1 and Threonine-51 in ππ Alcohol Dehydrogenases Archives of Biochemistry and Biophysics. 311: 307-312. PMID 8203892 DOI: 10.1006/Abbi.1994.1242 |
0.65 |
|
| 1994 |
Hurley TD, Bosron WF, Stone CL, Amzel LM. Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences. Journal of Molecular Biology. 239: 415-29. PMID 8201622 DOI: 10.1006/Jmbi.1994.1382 |
0.737 |
|
| 1994 |
Yang ZN, Davis GJ, Hurley TD, Stone CL, Li TK, Bosron WF. Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction Alcoholism: Clinical and Experimental Research. 18: 587-591. PMID 7943659 DOI: 10.1111/J.1530-0277.1994.Tb00914.X |
0.599 |
|
| 1993 |
Hurley TD, Yang Z, Bosron WF, Weiner H. Crystallization and preliminary X-ray analysis of bovine mitochondrial aldehyde dehydrogenase and human glutathione-dependent formaldehyde dehydrogenase Advances in Experimental Medicine and Biology. 328: 245-250. PMID 8493900 DOI: 10.1007/978-1-4615-2904-0_26 |
0.6 |
|
| 1993 |
Stone CL, Hurley TD, Amzel LM, Dunn MF, Bosron WF. Kinetics of a glycine for Arg-47 human alcohol dehydrogenase mutant can be explained by Lys-228 recruitment into the pyrophosphate binding site. Advances in Experimental Medicine and Biology. 328: 429-37. PMID 8388156 DOI: 10.1007/978-1-4615-2904-0_45 |
0.715 |
|
| 1993 |
Hurley TD, Bosron WF, Mario Amzel L. Human alcohol dehydrogenase: Design of a secondary alcohol dehydrogenase using crystallography and mutagenesis Protein Engineering, Design and Selection. 6: 44. DOI: 10.1093/Protein/6.Supplement.44-A |
0.619 |
|
| 1992 |
Ehrig T, Muhoberac BB, Hurley TD, Bosron WF. Tryptophan fluorescence quenching by alkaline pH and ternary complex formation in human β1β1 and horse EE alcohol dehydrogenases Febs Letters. 300: 283-285. PMID 1555656 DOI: 10.1016/0014-5793(92)80864-D |
0.613 |
|
| 1992 |
Hurley TD, Bosron WF. Human alcohol dehydrogenase: Dependence of secondary alcohol oxidation on the amino acids at positions 93 and 94 Biochemical and Biophysical Research Communications. 183: 93-99. PMID 1543513 DOI: 10.1016/0006-291X(92)91613-U |
0.628 |
|
| 1991 |
Hurley TD, Ehrig T, Edenberg HJ, Bosron WF. Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51 Advances in Experimental Medicine and Biology. 284: 271-275. PMID 2053482 DOI: 10.1007/978-1-4684-5901-2_29 |
0.671 |
|
| 1991 |
Ehrig T, Hurley TD, Edenberg HJ, Bosron WF. General Base Catalysis in a Glutamine for Histidine Mutant at Position 51 of Human Liver Alcohol Dehydrogenase Biochemistry. 30: 1062-1068. PMID 1989677 DOI: 10.1021/Bi00218A026 |
0.67 |
|
| 1991 |
Hurley TD, Bosron WF, Hamilton JA, Amzel LM. Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proceedings of the National Academy of Sciences of the United States of America. 88: 8149-53. PMID 1896463 DOI: 10.1073/Pnas.88.18.8149 |
0.751 |
|
| 1990 |
Hurley TD, Edenberg HJ, Bosron WF. Expression and kinetic characterization of variants of human β1β1 alcohol dehydrogenase containing substitutions at amino acid 47 Journal of Biological Chemistry. 265: 16366-16372. PMID 2398055 |
0.683 |
|
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