| Year |
Citation |
Score |
| 2018 |
Capdevila JH, Falck JR. The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance. Journal of Lipid Research. PMID 30154230 DOI: 10.1194/Jlr.R087882 |
0.32 |
|
| 2016 |
Guo Z, Sevrioukova I, Hanse E, Zhang X, Denisov I, Chiu T, Cuellar R, Torres C, Wulfkuhle J, Petricoin E, Cao Q, Chu H, Norris B, Schumacher R, Kelekar A, ... ... Capdevila J, et al. Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis Cancer Research. 76: 44-44. DOI: 10.1158/1538-7445.Am2016-44 |
0.344 |
|
| 2014 |
Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Atcha R, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB. 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. Journal of Medicinal Chemistry. 57: 6965-72. PMID 25119815 DOI: 10.1021/Jm500262M |
0.302 |
|
| 2013 |
Capdevila J, Wang W. Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension. Current Opinion in Nephrology and Hypertension. 22: 163-9. PMID 23302865 DOI: 10.1097/Mnh.0B013E32835D911E |
0.373 |
|
| 2012 |
Sun P, Antoun J, Lin DH, Yue P, Gotlinger KH, Capdevila J, Wang WH. Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake. Hypertension. 59: 339-47. PMID 22184322 DOI: 10.1161/Hypertensionaha.111.178475 |
0.323 |
|
| 2012 |
Guo Z, Mitra R, Luo X, Capdevila J, Lipscomb J, David PA. Abstract 942: CYP3A4 epoxygenase mediates hypoxia-induced biosynthesis of epoxyeicosatrienoic acids (±)-11,12- and (±)-14,15-EET in breast cancer cells Cancer Research. 72: 942-942. DOI: 10.1158/1538-7445.Am2012-942 |
0.307 |
|
| 2011 |
Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). The Journal of Biological Chemistry. 286: 17543-59. PMID 21402692 DOI: 10.1074/Jbc.M110.198515 |
0.361 |
|
| 2011 |
Potter DA, Guo Z, Mitra R, Milani M, Rodriguez M, Ding L, Bliss R, Nguyen J, Luo X, Gupta K, Capdevila J, Blair I, Thomas D, Bae YK. Abstract 357: CYP3A4 Activates Stat3 in ER + breast cancer Cancer Research. 71: 357-357. DOI: 10.1158/1538-7445.Am2011-357 |
0.318 |
|
| 2010 |
HECKMANN B, MIOSKOWSKI C, LUMIN S, FALCK JR, WEI S, CAPDEVILA JH. ChemInform Abstract: Chiral Acetals: Stereocontrolled Syntheses of 16-, 17-, and 18- Hydroxyeicosatetraenoic Acids, Cytochrome P-450 Arachidonate Metabolites. Cheminform. 27: no-no. DOI: 10.1002/chin.199624058 |
0.337 |
|
| 2008 |
Chen JK, Chen J, Imig JD, Wei S, Hachey DL, Guthi JS, Falck JR, Capdevila JH, Harris RC. Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. The Journal of Biological Chemistry. 283: 24514-24. PMID 18606824 DOI: 10.1074/Jbc.M709873200 |
0.369 |
|
| 2006 |
Wei S, Brittin JJ, Falck JR, Anjaiah S, Nithipatikom K, Cui L, Campbell WB, Capdevila JH. Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. Analytical Biochemistry. 352: 129-34. PMID 16480681 DOI: 10.1016/J.Ab.2006.01.005 |
0.336 |
|
| 2005 |
Parmentier JH, Lavrentyev EN, Falck JR, Capdevila JH, Malik KU. Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. Life Sciences. 77: 1015-29. PMID 15964316 DOI: 10.1016/J.Lfs.2005.03.002 |
0.327 |
|
| 2003 |
Ladd PA, Du L, Capdevila JH, Mernaugh R, Keeney DS. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. The Journal of Biological Chemistry. 278: 35184-92. PMID 12840027 DOI: 10.1074/jbc.M301666200 |
0.307 |
|
| 2002 |
Capdevila JH, Falck JR. Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. Prostaglandins & Other Lipid Mediators. 68: 325-44. PMID 12432927 DOI: 10.1016/S0090-6980(02)00038-2 |
0.336 |
|
| 2002 |
Cowart LA, Wei S, Hsu MH, Johnson EF, Krishna MU, Falck JR, Capdevila JH. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. The Journal of Biological Chemistry. 277: 35105-12. PMID 12124379 DOI: 10.1074/Jbc.M201575200 |
0.627 |
|
| 2002 |
Chen JK, Capdevila J, Harris RC. Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 6029-34. PMID 11983897 DOI: 10.1073/Pnas.092671899 |
0.386 |
|
| 2001 |
Chen JK, Capdevila J, Harris RC. Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis Molecular and Cellular Biology. 21: 6322-6331. PMID 11509673 DOI: 10.1128/Mcb.21.18.6322-6331.2001 |
0.42 |
|
| 2001 |
Cowart LA, Falck JR, Capdevila JH. Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. Archives of Biochemistry and Biophysics. 387: 117-24. PMID 11368173 DOI: 10.1006/Abbi.2000.2246 |
0.611 |
|
| 2000 |
Capdevila JH, Falck JR. Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase Prostaglandins and Other Lipid Mediators. 62: 271-292. PMID 10963794 DOI: 10.1016/S0090-6980(00)00085-X |
0.3 |
|
| 2000 |
Chen JK, Capdevila J, Harris RC. Overexpression of C-terminal Src kinase blocks 14,15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis Journal of Biological Chemistry. 275: 13789-13792. PMID 10788500 DOI: 10.1074/Jbc.275.18.13789 |
0.312 |
|
| 1999 |
Chen J, Wang DW, Falck JR, Capdevila J, Harris RC. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor Journal of Biological Chemistry. 274: 4764-4769. PMID 9988714 DOI: 10.1074/Jbc.274.8.4764 |
0.385 |
|
| 1998 |
Chen JK, Falck JR, Reddy KM, Capdevila J, Harris RC. Epoxyeicosatrienoic Acids And Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation And Induce Mitogenesis In Renal Epithelial Cells Journal of Biological Chemistry. 273: 29254-29261. PMID 9786938 DOI: 10.1074/Jbc.273.44.29254 |
0.34 |
|
| 1997 |
Graham-Lorence S, Truan G, Peterson JA, Falck JR, Wei S, Helvig C, Capdevila JH. An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase. The Journal of Biological Chemistry. 272: 1127-35. PMID 8995412 DOI: 10.1074/Jbc.272.2.1127 |
0.366 |
|
| 1997 |
Falck J, Belosludtsev YY, Reddy K, Reddy KM, Shortt M, Chauhan K, Capdevila JH, Wei S. Eicosanoid biosynthesis: differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase Bioorganic & Medicinal Chemistry Letters. 7: 3053-3056. DOI: 10.1016/S0960-894X(97)10144-5 |
0.326 |
|
| 1996 |
Makita K, Falck JR, Capdevila JH. Cytochrome P450, the arachidonic acid cascade, and hypertension: New vistas for an old enzyme system Faseb Journal. 10: 1456-1463. PMID 8940291 DOI: 10.1096/Fasebj.10.13.8940291 |
0.367 |
|
| 1996 |
Capdevila JH, Wei S, Helvig C, Falck JR, Belosludtsev Y, Truan G, Graham-Lorence SE, Peterson JA. The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. The Journal of Biological Chemistry. 271: 22663-71. PMID 8798438 DOI: 10.1074/Jbc.271.37.22663 |
0.35 |
|
| 1995 |
Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, Capdevila JH. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. The Journal of Clinical Investigation. 95: 2150-60. PMID 7738183 DOI: 10.1172/Jci117904 |
0.359 |
|
| 1995 |
Brash AR, Boeglin WE, Capdevila JH, Yeola S, Blair IA. 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. Archives of Biochemistry and Biophysics. 321: 485-92. PMID 7646075 DOI: 10.1006/Abbi.1995.1421 |
0.344 |
|
| 1995 |
Burns KD, Capdevila J, Wei S, Breyer MD, Homma T, Harris RC. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule American Journal of Physiology-Cell Physiology. 269. PMID 7485450 DOI: 10.1152/Ajpcell.1995.269.4.C831 |
0.344 |
|
| 1992 |
Capdevila JH, Dishman E, Karara A, Falck JR. Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. Methods in Enzymology. 206: 441-53. PMID 1784229 DOI: 10.1016/0076-6879(91)06113-H |
0.378 |
|
| 1992 |
Falck J, Lumin S, Lee S, Heckmann B, Mioskowski C, Karara A, Capdevila J. Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites Tetrahedron Letters. 33: 4893-4896. DOI: 10.1016/S0040-4039(00)61226-1 |
0.394 |
|
| 1991 |
Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. The American Journal of Physiology. 261: F578-86. PMID 1928373 DOI: 10.1152/Ajprenal.1991.261.4.F578 |
0.387 |
|
| 1990 |
Capdevila JH, Falck JR, Dishman E, Karara A. Cytochrome P-450 arachidonate oxygenase. Methods in Enzymology. 187: 385-94. PMID 2233355 DOI: 10.1016/0076-6879(90)87045-5 |
0.322 |
|
| 1990 |
Falck JR, Yadagiri P, Capdevila J. Synthesis of epoxyeicosatrienoic acids and heteroatom analogs Methods in Enzymology. 187: 357-364. PMID 2233353 DOI: 10.1016/0076-6879(90)87042-2 |
0.358 |
|
| 1990 |
Harris RC, Homma T, Jacobson HR, Capdevila J. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. Journal of Cellular Physiology. 144: 429-37. PMID 2167900 DOI: 10.1002/Jcp.1041440310 |
0.361 |
|
| 1990 |
Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. The American Journal of Physiology. 258: F781-9. PMID 2109933 DOI: 10.1152/Ajprenal.1990.258.4.F781 |
0.351 |
|
| 1990 |
Junier MP, Dray F, Blair I, Capdevila J, Dishman E, Falck JR, Ojeda SR. Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin. Endocrinology. 126: 1534-40. PMID 1968382 DOI: 10.1210/Endo-126-3-1534 |
0.353 |
|
| 1989 |
Ojeda SR, Urbanski HF, Junier MP, Capdevila J. The role of arachidonic acid and its metabolites in the release of neuropeptides. Annals of the New York Academy of Sciences. 559: 192-207. PMID 2570542 DOI: 10.1111/J.1749-6632.1989.Tb22609.X |
0.359 |
|
| 1989 |
Hirt DL, Capdevila J, Falck JR, Breyer MD, Jacobson HR. Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct. The Journal of Clinical Investigation. 84: 1805-12. PMID 2556446 DOI: 10.1172/Jci114365 |
0.364 |
|
| 1989 |
Orellana M, Valdés E, Capdevila J, Gil L. Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450 Archives of Biochemistry and Biophysics. 274: 251-258. PMID 2505677 DOI: 10.1016/0003-9861(89)90437-2 |
0.414 |
|
| 1989 |
Muirhead EE, Byers LW, Capdevila J, Brooks B, Pitcock JA, Brown PS. The renal antihypertensive endocrine function: its relation to cytochrome P-450. Journal of Hypertension. 7: 361-369. PMID 2504817 DOI: 10.1097/00004872-198905000-00003 |
0.379 |
|
| 1988 |
Lapuerta L, Chacos N, Falck JR, Jacobson H, Capdevila JH. Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. The American Journal of the Medical Sciences. 295: 275-9. PMID 3364462 DOI: 10.1097/00000441-198804000-00010 |
0.346 |
|
| 1988 |
Capdevila JH, Mosset P, Yadagiri P, Lumin S, Falck JR. NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. Archives of Biochemistry and Biophysics. 261: 122-33. PMID 3341770 DOI: 10.1016/0003-9861(88)90111-7 |
0.363 |
|
| 1988 |
Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR. Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Archives of Biochemistry and Biophysics. 261: 257-63. PMID 3128168 DOI: 10.1016/0003-9861(88)90340-2 |
0.439 |
|
| 1987 |
Carroll MA, Schwartzman M, Capdevila J, Falck JR, McGiff JC. Vasoactivity of arachidonic acid epoxides. European Journal of Pharmacology. 138: 281-3. PMID 3622613 DOI: 10.1016/0014-2999(87)90445-6 |
0.41 |
|
| 1987 |
Toto R, Siddhanta A, Manna S, Pramanik B, Faick JR, Capdevila J. Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 919: 132-139. PMID 3580381 DOI: 10.1016/0005-2760(87)90199-8 |
0.354 |
|
| 1986 |
Capdevila J, Yadagiri P, Manna S, Falck JR. Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450 Biochemical and Biophysical Research Communications. 141: 1007-1011. PMID 3101677 DOI: 10.1016/S0006-291X(86)80144-9 |
0.464 |
|
| 1986 |
Yadagiri P, Lumin S, Hosset P, Capdevila J, Falck J. Enantiospecific total synthesis of 8- and 12-hydroxyeicosatetraenoic acid Tetrahedron Letters. 27: 6039-6040. DOI: 10.1016/S0040-4039(00)85392-7 |
0.396 |
|
| 1986 |
Mosset P, Yadagiri P, Lumin S, Capdevila J, Falck J. Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid Tetrahedron Letters. 27: 6035-6038. DOI: 10.1016/S0040-4039(00)85391-5 |
0.39 |
|
| 1985 |
Falck J, Manna S, Viala J, Siddhanta AK, Moustakis CA, Capdevila J. Arachidonate epoxygenase: inhibitors and metabolite analogues Tetrahedron Letters. 26: 2287-2290. DOI: 10.1016/S0040-4039(00)95076-7 |
0.38 |
|
| 1984 |
Capdevila J, Pramanik B, Napoli JL, Manna S, Falck JR. Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver. Archives of Biochemistry and Biophysics. 231: 511-7. PMID 6732246 DOI: 10.1016/0003-9861(84)90415-6 |
0.391 |
|
| 1984 |
Capdevila J, Snijder GD, Falck JR. Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions Febs Letters. 178: 319-322. PMID 6439577 DOI: 10.1016/0014-5793(84)80625-0 |
0.305 |
|
| 1984 |
Capdevila J, Saeki Y, Falck JR. The mechanistic plurality of cytochrome p-450 and its biological ramifications Xenobiotica. 14: 105-118. PMID 6326392 DOI: 10.3109/00498258409151401 |
0.328 |
|
| 1984 |
Falck JR, Manna S, Jacobson HR, Estabrook RW, Chacos N, Capdevila J. Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450 Journal of the American Chemical Society. 106: 3334-3336. DOI: 10.1002/Chin.198436170 |
0.427 |
|
| 1984 |
Capdevila J, Snyder GG, Falck JR, Estabrook RW. The cytochrome P450-dependent metabolism of arachidonic acid Prostaglandins. 28: 659. |
0.332 |
|
| 1983 |
Manna S, Falck JR, Chacos N, Capdevila J. Synthesis of arachidonic acid metabolites produced by purified kidney cortex microsomal cytochrome P-450 Tetrahedron Letters. 24: 33-36. DOI: 10.1016/S0040-4039(00)81319-2 |
0.315 |
|
| 1982 |
Chacos N, Falck JR, Wixtrom C, Capdevila J. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid Biochemical and Biophysical Research Communications. 104: 916-922. PMID 6803794 DOI: 10.1016/0006-291X(82)91336-5 |
0.323 |
|
| 1981 |
Estabrook RW, Capdevila J, Prough RA. Liver microsomal cytochrome P-450 and the metabolism of arachidonic acid Pharmacologist. 23: no. 6. |
0.301 |
|
| 1973 |
Capdevila J, Morello A, Perry AS, Agosin M. Effect of phenobarbital and naphthalene on some of the components of the electron transport system and the hydroxylating activity of house fly microsomes Biochemistry. 12: 1445-1451. PMID 4696758 DOI: 10.1021/Bi00731A027 |
0.373 |
|
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