| Year |
Citation |
Score |
| 2018 |
Capdevila JH, Falck JR. The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance. Journal of Lipid Research. PMID 30154230 DOI: 10.1194/Jlr.R087882 |
0.32 |
|
| 2016 |
Guo Z, Sevrioukova I, Hanse E, Zhang X, Denisov I, Chiu T, Cuellar R, Torres C, Wulfkuhle J, Petricoin E, Cao Q, Chu H, Norris B, Schumacher R, Kelekar A, ... ... Capdevila J, et al. Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis Cancer Research. 76: 44-44. DOI: 10.1158/1538-7445.Am2016-44 |
0.344 |
|
| 2014 |
Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Atcha R, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB. 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. Journal of Medicinal Chemistry. 57: 6965-72. PMID 25119815 DOI: 10.1021/Jm500262M |
0.302 |
|
| 2013 |
Capdevila J, Wang W. Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension. Current Opinion in Nephrology and Hypertension. 22: 163-9. PMID 23302865 DOI: 10.1097/Mnh.0B013E32835D911E |
0.373 |
|
| 2012 |
Sun P, Antoun J, Lin DH, Yue P, Gotlinger KH, Capdevila J, Wang WH. Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake. Hypertension. 59: 339-47. PMID 22184322 DOI: 10.1161/Hypertensionaha.111.178475 |
0.323 |
|
| 2012 |
Guo Z, Mitra R, Luo X, Capdevila J, Lipscomb J, David PA. Abstract 942: CYP3A4 epoxygenase mediates hypoxia-induced biosynthesis of epoxyeicosatrienoic acids (±)-11,12- and (±)-14,15-EET in breast cancer cells Cancer Research. 72: 942-942. DOI: 10.1158/1538-7445.Am2012-942 |
0.307 |
|
| 2011 |
Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). The Journal of Biological Chemistry. 286: 17543-59. PMID 21402692 DOI: 10.1074/Jbc.M110.198515 |
0.361 |
|
| 2011 |
Potter DA, Guo Z, Mitra R, Milani M, Rodriguez M, Ding L, Bliss R, Nguyen J, Luo X, Gupta K, Capdevila J, Blair I, Thomas D, Bae YK. Abstract 357: CYP3A4 Activates Stat3 in ER + breast cancer Cancer Research. 71: 357-357. DOI: 10.1158/1538-7445.Am2011-357 |
0.318 |
|
| 2010 |
HECKMANN B, MIOSKOWSKI C, LUMIN S, FALCK JR, WEI S, CAPDEVILA JH. ChemInform Abstract: Chiral Acetals: Stereocontrolled Syntheses of 16-, 17-, and 18- Hydroxyeicosatetraenoic Acids, Cytochrome P-450 Arachidonate Metabolites. Cheminform. 27: no-no. DOI: 10.1002/chin.199624058 |
0.337 |
|
| 2008 |
Chen JK, Chen J, Imig JD, Wei S, Hachey DL, Guthi JS, Falck JR, Capdevila JH, Harris RC. Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. The Journal of Biological Chemistry. 283: 24514-24. PMID 18606824 DOI: 10.1074/Jbc.M709873200 |
0.369 |
|
| 2006 |
Wei S, Brittin JJ, Falck JR, Anjaiah S, Nithipatikom K, Cui L, Campbell WB, Capdevila JH. Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. Analytical Biochemistry. 352: 129-34. PMID 16480681 DOI: 10.1016/J.Ab.2006.01.005 |
0.336 |
|
| 2005 |
Parmentier JH, Lavrentyev EN, Falck JR, Capdevila JH, Malik KU. Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. Life Sciences. 77: 1015-29. PMID 15964316 DOI: 10.1016/J.Lfs.2005.03.002 |
0.327 |
|
| 2003 |
Ladd PA, Du L, Capdevila JH, Mernaugh R, Keeney DS. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. The Journal of Biological Chemistry. 278: 35184-92. PMID 12840027 DOI: 10.1074/jbc.M301666200 |
0.307 |
|
| 2002 |
Capdevila JH, Falck JR. Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. Prostaglandins & Other Lipid Mediators. 68: 325-44. PMID 12432927 DOI: 10.1016/S0090-6980(02)00038-2 |
0.336 |
|
| 2002 |
Cowart LA, Wei S, Hsu MH, Johnson EF, Krishna MU, Falck JR, Capdevila JH. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. The Journal of Biological Chemistry. 277: 35105-12. PMID 12124379 DOI: 10.1074/Jbc.M201575200 |
0.627 |
|
| 2002 |
Chen JK, Capdevila J, Harris RC. Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 6029-34. PMID 11983897 DOI: 10.1073/Pnas.092671899 |
0.386 |
|
| 2001 |
Chen JK, Capdevila J, Harris RC. Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis Molecular and Cellular Biology. 21: 6322-6331. PMID 11509673 DOI: 10.1128/Mcb.21.18.6322-6331.2001 |
0.42 |
|
| 2001 |
Cowart LA, Falck JR, Capdevila JH. Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. Archives of Biochemistry and Biophysics. 387: 117-24. PMID 11368173 DOI: 10.1006/Abbi.2000.2246 |
0.611 |
|
| 2000 |
Capdevila JH, Falck JR. Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase Prostaglandins and Other Lipid Mediators. 62: 271-292. PMID 10963794 DOI: 10.1016/S0090-6980(00)00085-X |
0.3 |
|
| 2000 |
Chen JK, Capdevila J, Harris RC. Overexpression of C-terminal Src kinase blocks 14,15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis Journal of Biological Chemistry. 275: 13789-13792. PMID 10788500 DOI: 10.1074/Jbc.275.18.13789 |
0.312 |
|
| 1999 |
Chen J, Wang DW, Falck JR, Capdevila J, Harris RC. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor Journal of Biological Chemistry. 274: 4764-4769. PMID 9988714 DOI: 10.1074/Jbc.274.8.4764 |
0.385 |
|
| 1998 |
Chen JK, Falck JR, Reddy KM, Capdevila J, Harris RC. Epoxyeicosatrienoic Acids And Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation And Induce Mitogenesis In Renal Epithelial Cells Journal of Biological Chemistry. 273: 29254-29261. PMID 9786938 DOI: 10.1074/Jbc.273.44.29254 |
0.34 |
|
| 1997 |
Graham-Lorence S, Truan G, Peterson JA, Falck JR, Wei S, Helvig C, Capdevila JH. An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase. The Journal of Biological Chemistry. 272: 1127-35. PMID 8995412 DOI: 10.1074/Jbc.272.2.1127 |
0.366 |
|
| 1997 |
Falck J, Belosludtsev YY, Reddy K, Reddy KM, Shortt M, Chauhan K, Capdevila JH, Wei S. Eicosanoid biosynthesis: differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase Bioorganic & Medicinal Chemistry Letters. 7: 3053-3056. DOI: 10.1016/S0960-894X(97)10144-5 |
0.326 |
|
| 1996 |
Makita K, Falck JR, Capdevila JH. Cytochrome P450, the arachidonic acid cascade, and hypertension: New vistas for an old enzyme system Faseb Journal. 10: 1456-1463. PMID 8940291 DOI: 10.1096/Fasebj.10.13.8940291 |
0.367 |
|
| 1996 |
Capdevila JH, Wei S, Helvig C, Falck JR, Belosludtsev Y, Truan G, Graham-Lorence SE, Peterson JA. The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. The Journal of Biological Chemistry. 271: 22663-71. PMID 8798438 DOI: 10.1074/Jbc.271.37.22663 |
0.35 |
|
| 1995 |
Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, Capdevila JH. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. The Journal of Clinical Investigation. 95: 2150-60. PMID 7738183 DOI: 10.1172/Jci117904 |
0.359 |
|
| 1995 |
Brash AR, Boeglin WE, Capdevila JH, Yeola S, Blair IA. 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. Archives of Biochemistry and Biophysics. 321: 485-92. PMID 7646075 DOI: 10.1006/Abbi.1995.1421 |
0.344 |
|
| 1995 |
Burns KD, Capdevila J, Wei S, Breyer MD, Homma T, Harris RC. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule American Journal of Physiology-Cell Physiology. 269. PMID 7485450 DOI: 10.1152/Ajpcell.1995.269.4.C831 |
0.344 |
|
| 1992 |
Capdevila JH, Dishman E, Karara A, Falck JR. Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. Methods in Enzymology. 206: 441-53. PMID 1784229 DOI: 10.1016/0076-6879(91)06113-H |
0.378 |
|
| 1992 |
Falck J, Lumin S, Lee S, Heckmann B, Mioskowski C, Karara A, Capdevila J. Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites Tetrahedron Letters. 33: 4893-4896. DOI: 10.1016/S0040-4039(00)61226-1 |
0.394 |
|
| 1991 |
Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. The American Journal of Physiology. 261: F578-86. PMID 1928373 DOI: 10.1152/Ajprenal.1991.261.4.F578 |
0.387 |
|
| 1990 |
Capdevila JH, Falck JR, Dishman E, Karara A. Cytochrome P-450 arachidonate oxygenase. Methods in Enzymology. 187: 385-94. PMID 2233355 DOI: 10.1016/0076-6879(90)87045-5 |
0.322 |
|
| 1990 |
Falck JR, Yadagiri P, Capdevila J. Synthesis of epoxyeicosatrienoic acids and heteroatom analogs Methods in Enzymology. 187: 357-364. PMID 2233353 DOI: 10.1016/0076-6879(90)87042-2 |
0.358 |
|
| 1990 |
Harris RC, Homma T, Jacobson HR, Capdevila J. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. Journal of Cellular Physiology. 144: 429-37. PMID 2167900 DOI: 10.1002/Jcp.1041440310 |
0.361 |
|
| 1990 |
Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. The American Journal of Physiology. 258: F781-9. PMID 2109933 DOI: 10.1152/Ajprenal.1990.258.4.F781 |
0.351 |
|
| 1990 |
Junier MP, Dray F, Blair I, Capdevila J, Dishman E, Falck JR, Ojeda SR. Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin. Endocrinology. 126: 1534-40. PMID 1968382 DOI: 10.1210/Endo-126-3-1534 |
0.353 |
|
| 1989 |
Ojeda SR, Urbanski HF, Junier MP, Capdevila J. The role of arachidonic acid and its metabolites in the release of neuropeptides. Annals of the New York Academy of Sciences. 559: 192-207. PMID 2570542 DOI: 10.1111/J.1749-6632.1989.Tb22609.X |
0.359 |
|
| 1989 |
Hirt DL, Capdevila J, Falck JR, Breyer MD, Jacobson HR. Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct. The Journal of Clinical Investigation. 84: 1805-12. PMID 2556446 DOI: 10.1172/Jci114365 |
0.364 |
|
| 1989 |
Orellana M, Valdés E, Capdevila J, Gil L. Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450 Archives of Biochemistry and Biophysics. 274: 251-258. PMID 2505677 DOI: 10.1016/0003-9861(89)90437-2 |
0.414 |
|
| 1989 |
Muirhead EE, Byers LW, Capdevila J, Brooks B, Pitcock JA, Brown PS. The renal antihypertensive endocrine function: its relation to cytochrome P-450. Journal of Hypertension. 7: 361-369. PMID 2504817 DOI: 10.1097/00004872-198905000-00003 |
0.379 |
|
| 1988 |
Lapuerta L, Chacos N, Falck JR, Jacobson H, Capdevila JH. Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. The American Journal of the Medical Sciences. 295: 275-9. PMID 3364462 DOI: 10.1097/00000441-198804000-00010 |
0.346 |
|
| 1988 |
Capdevila JH, Mosset P, Yadagiri P, Lumin S, Falck JR. NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. Archives of Biochemistry and Biophysics. 261: 122-33. PMID 3341770 DOI: 10.1016/0003-9861(88)90111-7 |
0.363 |
|
| 1988 |
Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR. Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Archives of Biochemistry and Biophysics. 261: 257-63. PMID 3128168 DOI: 10.1016/0003-9861(88)90340-2 |
0.439 |
|
| 1987 |
Carroll MA, Schwartzman M, Capdevila J, Falck JR, McGiff JC. Vasoactivity of arachidonic acid epoxides. European Journal of Pharmacology. 138: 281-3. PMID 3622613 DOI: 10.1016/0014-2999(87)90445-6 |
0.41 |
|
| 1987 |
Toto R, Siddhanta A, Manna S, Pramanik B, Faick JR, Capdevila J. Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 919: 132-139. PMID 3580381 DOI: 10.1016/0005-2760(87)90199-8 |
0.354 |
|
| 1986 |
Capdevila J, Yadagiri P, Manna S, Falck JR. Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450 Biochemical and Biophysical Research Communications. 141: 1007-1011. PMID 3101677 DOI: 10.1016/S0006-291X(86)80144-9 |
0.464 |
|
| 1986 |
Yadagiri P, Lumin S, Hosset P, Capdevila J, Falck J. Enantiospecific total synthesis of 8- and 12-hydroxyeicosatetraenoic acid Tetrahedron Letters. 27: 6039-6040. DOI: 10.1016/S0040-4039(00)85392-7 |
0.396 |
|
| 1986 |
Mosset P, Yadagiri P, Lumin S, Capdevila J, Falck J. Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid Tetrahedron Letters. 27: 6035-6038. DOI: 10.1016/S0040-4039(00)85391-5 |
0.39 |
|
| 1985 |
Falck J, Manna S, Viala J, Siddhanta AK, Moustakis CA, Capdevila J. Arachidonate epoxygenase: inhibitors and metabolite analogues Tetrahedron Letters. 26: 2287-2290. DOI: 10.1016/S0040-4039(00)95076-7 |
0.38 |
|
| 1984 |
Capdevila J, Pramanik B, Napoli JL, Manna S, Falck JR. Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver. Archives of Biochemistry and Biophysics. 231: 511-7. PMID 6732246 DOI: 10.1016/0003-9861(84)90415-6 |
0.391 |
|
| 1984 |
Capdevila J, Snijder GD, Falck JR. Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions Febs Letters. 178: 319-322. PMID 6439577 DOI: 10.1016/0014-5793(84)80625-0 |
0.305 |
|
| 1984 |
Capdevila J, Saeki Y, Falck JR. The mechanistic plurality of cytochrome p-450 and its biological ramifications Xenobiotica. 14: 105-118. PMID 6326392 DOI: 10.3109/00498258409151401 |
0.328 |
|
| 1984 |
Falck JR, Manna S, Jacobson HR, Estabrook RW, Chacos N, Capdevila J. Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450 Journal of the American Chemical Society. 106: 3334-3336. DOI: 10.1002/Chin.198436170 |
0.427 |
|
| 1984 |
Capdevila J, Snyder GG, Falck JR, Estabrook RW. The cytochrome P450-dependent metabolism of arachidonic acid Prostaglandins. 28: 659. |
0.332 |
|
| 1983 |
Manna S, Falck JR, Chacos N, Capdevila J. Synthesis of arachidonic acid metabolites produced by purified kidney cortex microsomal cytochrome P-450 Tetrahedron Letters. 24: 33-36. DOI: 10.1016/S0040-4039(00)81319-2 |
0.315 |
|
| 1982 |
Chacos N, Falck JR, Wixtrom C, Capdevila J. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid Biochemical and Biophysical Research Communications. 104: 916-922. PMID 6803794 DOI: 10.1016/0006-291X(82)91336-5 |
0.323 |
|
| 1981 |
Estabrook RW, Capdevila J, Prough RA. Liver microsomal cytochrome P-450 and the metabolism of arachidonic acid Pharmacologist. 23: no. 6. |
0.301 |
|
| 1973 |
Capdevila J, Morello A, Perry AS, Agosin M. Effect of phenobarbital and naphthalene on some of the components of the electron transport system and the hydroxylating activity of house fly microsomes Biochemistry. 12: 1445-1451. PMID 4696758 DOI: 10.1021/Bi00731A027 |
0.373 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1987 |
MOSSET P, YADAGIRI P, LUMIN S, CAPDEVILA J, FALCK JR. ChemInform Abstract: Arachidonate Epoxygenase: Total Synthesis of Both Enantiomers of 8,9and 11,12-Epoxyeicosatrienoic Acid. Cheminform. 18. DOI: 10.1002/chin.198720358 |
0.299 |
|
| 1992 |
Jajoo HK, Capdevila JH, Falck JR, Bhatt RK, Blair IA. Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. Biochimica Et Biophysica Acta. 1123: 110-6. PMID 1730042 DOI: 10.1016/0005-2760(92)90177-W |
0.298 |
|
| 1990 |
Karara A, Dishman E, Jacobson H, Falck JR, Capdevila JH. Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. Febs Letters. 268: 227-30. PMID 2384159 DOI: 10.1016/0014-5793(90)81014-F |
0.297 |
|
| 2005 |
Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. The Journal of Biological Chemistry. 280: 27138-46. PMID 15917237 DOI: 10.1074/Jbc.M501730200 |
0.296 |
|
| 2010 |
CHAUHAN K, ARAVIND S, LEE S, FALCK JR, CAPDEVILA JH. ChemInform Abstract: vic-Diol Chirons: Enantiospecific Synthesis of 11,12- and 14,15- Dihydroxyeicosatrienoic Acids. Cheminform. 26: no-no. DOI: 10.1002/chin.199507253 |
0.293 |
|
| 1987 |
YADAGIRI P, LUMIN S, MOSSET P, CAPDEVILA J, FALCK JR. ChemInform Abstract: Enantiospecific Total Synthesis of 8- and 12-Hydroxyeicosatetraenoic Acid. Cheminform. 18. DOI: 10.1002/chin.198720359 |
0.29 |
|
| 2007 |
Chen J, Chen JK, Falck JR, Guthi JS, Anjaiah S, Capdevila JH, Harris RC. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Molecular and Cellular Biology. 27: 3023-34. PMID 17283047 DOI: 10.1128/Mcb.01482-06 |
0.29 |
|
| 2004 |
Quan A, Chakravarty S, Chen JK, Chen JC, Loleh S, Saini N, Harris RC, Capdevila J, Quigley R. Androgens augment proximal tubule transport. American Journal of Physiology. Renal Physiology. 287: F452-9. PMID 15100096 DOI: 10.1152/Ajprenal.00188.2003 |
0.284 |
|
| 1992 |
Capdevila JH, Falck JR, Estabrook RW. Cytochrome P450 and the arachidonate cascade. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 6: 731-6. PMID 1537463 DOI: 10.1096/Fasebj.6.2.1537463 |
0.284 |
|
| 1996 |
Heckmann B, Mioskowski C, Lumin S, Falck J, Wei S, Capdevila JH. Chiral acetals: Stereocontrolled syntheses of 16-, 17-, and 18-hydroxyeicosatetraenoic acids, cytochrome P-450 arachidonate metabolites Tetrahedron Letters. 37: 1425-1428. DOI: 10.1016/0040-4039(96)00059-7 |
0.281 |
|
| 1993 |
Reddy KK, Falck JR, Capdevila J. Insulin second messengers: Synthesis of 6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-chiro-inositol-1-phosphate Tetrahedron Letters. 34: 7869-7872. DOI: 10.1016/S0040-4039(00)61497-1 |
0.281 |
|
| 2015 |
Guo Z, Sevrioukova IF, Hanse E, Denisov I, Zhang X, Chiu T, Swedien D, Stamschror J, Alvarez J, Ortiz WM, Morgan M, Maher M, Chavez KJ, Thomas D, Bae YK, ... ... Capdevila J, et al. Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides Cancer Research. 75: 3568-3568. DOI: 10.1158/1538-7445.Am2015-3568 |
0.279 |
|
| 1999 |
Capdevila J, Holla V, owart A, Helvig C. Biochemical and functional properties of the P450 arachidonic acid monooxygenase Prostaglandins & Other Lipid Mediators. 59: 92. DOI: 10.1016/S0090-6980(99)90327-1 |
0.277 |
|
| 1985 |
Moustakis CA, Viala J, Capdevila J, Falck JR. Total synthesis of the cytochrome P-450 epoxygenase metabolites 5(R),6(S)-, 5(S),6(R)-, and 14(R),15(S)-epoxyeicosatrienoic acid (EET) and hydration products 5(R),6(R)- and 14(R),15(R)-dihydroxyeicosatrienoic acid (DHET) Journal of the American Chemical Society. 107: 5283-5285. DOI: 10.1002/Chin.198551322 |
0.276 |
|
| 2009 |
Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. Journal of Medicinal Chemistry. 52: 5069-75. PMID 19653681 DOI: 10.1021/Jm900634W |
0.276 |
|
| 1995 |
Capdevila JH, Morrow JD, Belosludtsev YY, Beauchamp DR, DuBois RN, Falck JR. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry. 34: 3325-37. PMID 7880828 DOI: 10.1021/Bi00010A023 |
0.274 |
|
| 2014 |
Guo Z, Chavez KJ, Alvarez J, Zhang X, Norris B, Maher M, Morgan M, Schumacher RJ, Cuellar R, Sevrioukova IF, Poulos TL, Denisov I, Sligar SG, Gupta K, Blair IA, ... Capdevila J, et al. Abstract 2689: Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide Cancer Research. 74: 2689-2689. DOI: 10.1158/1538-7445.Am2014-2689 |
0.273 |
|
| 2001 |
Capdevila JH, Falck JR. The CYP P450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation Biochemical and Biophysical Research Communications. 285: 571-576. PMID 11453630 DOI: 10.1006/Bbrc.2001.5167 |
0.271 |
|
| 2018 |
Sausville LN, Gangadhariah M, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. The cytochrome P450 slow metabolizers CYP2C9*2 and CYP2C9*3 directly regulate tumorigenesis via reduced epoxyeicosatrienoic acid production. Cancer Research. PMID 30012669 DOI: 10.1158/0008-5472.Can-17-3977 |
0.271 |
|
| 1998 |
Keeney DS, Skinner C, Travers JB, Capdevila JH, Nanney LB, King LE, Waterman MR. Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity. The Journal of Biological Chemistry. 273: 32071-9. PMID 9822682 DOI: 10.1074/Jbc.273.48.32071 |
0.269 |
|
| 1980 |
Capdevila J, Orrenius S. Metabolism of benzo[a]pyrene-3,6-quinone by isolated hepatocytes Febs Letters. 119: 33-37. PMID 6159233 DOI: 10.1016/0014-5793(80)80992-6 |
0.266 |
|
| 2001 |
Falck J, Kumar P, Reddy Y, Zou G, Capdevila JH. Stereospecific synthesis of EET metabolites via Suzuki–Miyaura coupling Tetrahedron Letters. 42: 7211-7212. DOI: 10.1016/S0040-4039(01)01535-0 |
0.264 |
|
| 1995 |
Zeldin DC, Wei S, Falck JR, Hammock BD, Snapper JR, Capdevila JH. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Archives of Biochemistry and Biophysics. 316: 443-51. PMID 7840649 DOI: 10.1006/Abbi.1995.1059 |
0.259 |
|
| 1987 |
Capdevila JH, Kishore V, Dishman E, Blair IA, Falck JR. A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). Biochemical and Biophysical Research Communications. 146: 638-44. PMID 3619897 DOI: 10.1016/0006-291X(87)90576-6 |
0.257 |
|
| 2000 |
Helvig C, Capdevila JH. Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains Biochemistry. 39: 5196-5205. PMID 10819987 DOI: 10.1021/bi992578v |
0.256 |
|
| 2017 |
Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, ... ... Capdevila JH, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology. PMID 28919040 DOI: 10.1016/J.Chembiol.2017.08.009 |
0.256 |
|
| 1995 |
Zeldin DC, DuBois RN, Falck JR, Capdevila JH. Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Archives of Biochemistry and Biophysics. 322: 76-86. PMID 7574697 DOI: 10.1006/Abbi.1995.1438 |
0.255 |
|
| 1981 |
Prough RA, Saeki Y, Capdevila J. The metabolism of benzo[a]pyrene phenols by rat liver microsomal fractions Archives of Biochemistry and Biophysics. 212: 136-146. PMID 7305398 DOI: 10.1016/0003-9861(81)90352-0 |
0.249 |
|
| 2006 |
Campbell WB, Holmes BB, Falck JR, Capdevila JH, Gauthier KM. Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. American Journal of Physiology. Heart and Circulatory Physiology. 290: H64-71. PMID 16143653 DOI: 10.1152/Ajpheart.00516.2005 |
0.241 |
|
| 2006 |
Falck JR, Anjaiah S, Tuniki VR, Gopal VR, Capdevila JH. Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid. Journal of Labelled Compounds & Radiopharmaceuticals. 49: 245-252. PMID 16951707 DOI: 10.1002/Jlcr.1039 |
0.241 |
|
| 1999 |
Holla VR, Makita K, Zaphiropoulos PG, Capdevila JH. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. The Journal of Clinical Investigation. 104: 751-60. PMID 10491410 DOI: 10.1172/JCI7013 |
0.24 |
|
| 2007 |
Pozzi A, Ibanez MR, Gatica AE, Yang S, Wei S, Mei S, Falck JR, Capdevila JH. Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. The Journal of Biological Chemistry. 282: 17685-95. PMID 17405874 DOI: 10.1074/Jbc.M701429200 |
0.24 |
|
| 1993 |
Capdevila JH, Wei S, Kumar A, Kobayashi J, Snapper JR, Zeldin DC, Bhatt RK, Falck JR. Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography. Analytical Biochemistry. 207: 236-40. PMID 1481976 DOI: 10.1016/0003-2697(92)90006-S |
0.24 |
|
| 1988 |
Proctor KG, Shatkin S, Kaminski PM, Falck JR, Capdevila JH. Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites. Circulation. 77: 1185-96. PMID 3129211 DOI: 10.1161/01.Cir.77.5.1185 |
0.239 |
|
| 1983 |
Falck JR, Manna S, Moltz J, Chacos N, Capdevila J. Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets Biochemical and Biophysical Research Communications. 114: 743-749. PMID 6411091 DOI: 10.1016/0006-291X(83)90843-4 |
0.238 |
|
| 2013 |
Pidkovka N, Rao R, Mei S, Gong Y, Harris RC, Wang WH, Capdevila JH. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. The Journal of Biological Chemistry. 288: 5223-31. PMID 23283969 DOI: 10.1074/Jbc.M112.407981 |
0.237 |
|
| 2005 |
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation. 111: 63-9. PMID 15611369 DOI: 10.1161/01.Cir.0000151309.82473.59 |
0.237 |
|
| 2003 |
Reddy YK, Reddy LM, Capdevila JH, Falck JR. Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. Bioorganic & Medicinal Chemistry Letters. 13: 3719-20. PMID 14552765 DOI: 10.1016/J.Bmcl.2003.08.005 |
0.235 |
|
| 2007 |
Capdevila JH, Falck JR, Imig JD. Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. Kidney International. 72: 683-9. PMID 17597703 DOI: 10.1038/Sj.Ki.5002394 |
0.234 |
|
| 2005 |
Du L, Yermalitsky V, Ladd PA, Capdevila JH, Mernaugh R, Keeney DS. Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin. Archives of Biochemistry and Biophysics. 435: 125-33. PMID 15680914 DOI: 10.1016/j.abb.2004.11.023 |
0.233 |
|
| 1976 |
Agosin M, Naquira C, Capdevila J, Paulin J. Hemoproteins in Trypanosoma cruzi with emphasis on microsomal pigments International Journal of Biochemistry. 7: 585-586. DOI: 10.1016/0020-711X(76)90080-X |
0.231 |
|
| 2015 |
Capdevila JH, Wang W, Falck JR. Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance. Prostaglandins & Other Lipid Mediators. 120: 40-9. PMID 25986599 DOI: 10.1016/J.Prostaglandins.2015.05.004 |
0.227 |
|
| 1973 |
Bleecker W, Capdevila J, Agosin M. Sequential solubilization of microsomal mixed function oxidases Journal of Biological Chemistry. 248: 8474-8481. PMID 4148673 |
0.22 |
|
| 1979 |
Woessner S, Lafuente R, Capdevila J, Sans Sabrafen J. Application of acid esterase to the study of lymphoproliferative syndromes with peripheral blood involvement Sangre. 24: 446-451. PMID 39352 |
0.219 |
|
| 2009 |
Yang S, Wei S, Pozzi A, Capdevila JH. The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Archives of Biochemistry and Biophysics. 489: 82-91. PMID 19464254 DOI: 10.1016/J.Abb.2009.05.006 |
0.216 |
|
| 1994 |
Makita K, Takahashi K, Karara A, Jacobson HR, Falck JR, Capdevila JH. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. The Journal of Clinical Investigation. 94: 2414-20. PMID 7989598 DOI: 10.1172/Jci117608 |
0.214 |
|
| 1975 |
Jernström B, Capdevila J, Jakobsson S, Orrenius S. Solubilization and partial purification of cytochrome P-450 from rat lung microsomes Biochemical and Biophysical Research Communications. 64: 814-822. PMID 807210 DOI: 10.1016/0006-291X(75)90120-5 |
0.214 |
|
| 1992 |
Lumin S, Falck JR, Capdevila J, Karara A. Palladium mediated allylic mitsunobu displacement: stereocontrolled synthesis of hepoxilin A3 and trioxilin A3 methyl esters Tetrahedron Letters. 33: 2091-2094. DOI: 10.1016/0040-4039(92)88148-X |
0.213 |
|
| 1975 |
Vadi H, Moldéus P, Capdevila J, Orrenius S. The Metabolism of Benzo(α)pyrene in Isolated Rat Liver Cells Cancer Research. 35: 2083-2091. PMID 1149022 |
0.213 |
|
| 1994 |
Chauhan K, Aravind S, Lee SG, Falck JR, Capdevila JH. vic-Diol chirons: Enantiospecific synthesis of 11,12- and 14,15-dihydroxyeicosatrienoic acids Tetrahedron Letters. 35: 6791-6794. DOI: 10.1016/0040-4039(94)85006-2 |
0.211 |
|
| 1975 |
Capdevila J, Jernström B, Vadi H, Orrenius S. Cytochrome P-450-linked activation of 3-hydroxybenzo(a)pyrene Biochemical and Biophysical Research Communications. 65: 894-900. PMID 1156423 DOI: 10.1016/S0006-291X(75)80469-4 |
0.211 |
|
| 2010 |
Pozzi A, Popescu V, Yang S, Mei S, Shi M, Puolitaival SM, Caprioli RM, Capdevila JH. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. The Journal of Biological Chemistry. 285: 12840-50. PMID 20178979 DOI: 10.1074/Jbc.M109.081554 |
0.21 |
|
| 2001 |
Imig JD, Zhao X, Falck JR, Wei S, Capdevila JH. Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. Journal of Hypertension. 19: 983-92. PMID 11393683 DOI: 10.1097/00004872-200105000-00020 |
0.209 |
|
| 2016 |
Savas U, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. 20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor. The Journal of Biological Chemistry. PMID 27298316 DOI: 10.1074/Jbc.M116.732297 |
0.206 |
|
| 1984 |
Falck JR, Manna S, Capdevila J. Enantiospecific synthesis of methyl 11,12- and 14,15-epoxyeicosatrienoate Tetrahedron Letters. 25: 2443-2446. DOI: 10.1016/S0040-4039(01)81200-4 |
0.204 |
|
| 1995 |
Sakairi Y, Jacobson HR, Noland TD, Capdevila JH, Falck JR, Breyer MD. 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. The American Journal of Physiology. 268: F931-9. PMID 7771521 DOI: 10.1152/Ajprenal.1995.268.5.F931 |
0.201 |
|
| 2014 |
Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB. Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications Journal of Medicinal Chemistry. 57: 9218-9218. DOI: 10.1021/Jm5016457 |
0.2 |
|
| 1987 |
LUMIN S, YADAGIRI P, FALCK JR, CAPDEVILA J, MOSSET P, GREE R. ChemInform Abstract: Total Synthesis of 5(S),20- and 15(S),20-Dihydroxyeicosatetraenoic Acid and 5(S),6(R)-Epoxy-20-hydroxy- and 14(R),15(S)-Epoxy-20-hydroxyeicosatrienoic Acid. Cheminform. 18. DOI: 10.1002/chin.198738349 |
0.199 |
|
| 2004 |
Pozzi A, Yan X, Macias-Perez I, Wei S, Hata AN, Breyer RM, Morrow JD, Capdevila JH. Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. The Journal of Biological Chemistry. 279: 29797-804. PMID 15123663 DOI: 10.1074/Jbc.M313989200 |
0.199 |
|
| 2013 |
Ding Y, Wu CC, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, Zhang F, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML. 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. American Journal of Physiology. Renal Physiology. 305: F753-63. PMID 23825080 DOI: 10.1152/Ajprenal.00292.2013 |
0.198 |
|
| 2008 |
Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, Brown NJ, Elijovich F. The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension. 51: 767-72. PMID 18227405 DOI: 10.1161/Hypertensionaha.107.102921 |
0.196 |
|
| 2017 |
Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML. HETE Signals Through G Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension. Circulation Research. PMID 28325781 DOI: 10.1161/Circresaha.116.310525 |
0.196 |
|
| 2001 |
Imig JD, Falck JR, Wei S, Capdevila JH. Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin. Journal of Vascular Research. 38: 247-55. PMID 11399897 DOI: 10.1159/000051053 |
0.193 |
|
| 1979 |
Lubet RA, Capdevila J, Prough RA. The metabolic activation of benzo(a)pyrene and 9-hydroxybenzo(a)pyrene by liver microsomal fractions International Journal of Cancer. 23: 353-357. PMID 374283 DOI: 10.1002/ijc.2910230313 |
0.193 |
|
| 1994 |
Belosludtsev YY, Kollah R, Falck J, Capdevila JH. Hepoxilins B3: Synthesis of all four stereoisomers and a glutathione adduct Tetrahedron Letters. 35: 5327-5330. DOI: 10.1016/S0040-4039(00)73491-5 |
0.19 |
|
| 1999 |
Falck J, Krishna U, Capdevila JH. A synthesis of l-α-phosphatidyl-d-myo-inositol 4,5-bisphosphate (4,5-PIP2) and glyceryl lipid analogs Tetrahedron Letters. 40: 8771-8774. DOI: 10.1016/S0040-4039(99)01877-8 |
0.19 |
|
| 1990 |
Hammonds TD, Blair IA, Falck JR, Capdevila JH. Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. Analytical Biochemistry. 182: 300-3. PMID 2610347 DOI: 10.1016/0003-2697(89)90598-8 |
0.187 |
|
| 1975 |
Capdevila J, Ahmad N, Agosin M. Soluble cytochrome P 450 from housefly microsomes. Partial purification and characterization of two hemoprotein forms Journal of Biological Chemistry. 250: 1048-1060. PMID 234439 |
0.184 |
|
| 2014 |
Hye Khan MA, Pavlov TS, Christain SV, Neckář J, Staruschenko A, Gauthier KM, Capdevila JH, Falck JR, Campbell WB, Imig JD. Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition. Clinical Science (London, England : 1979). 127: 463-74. PMID 24707975 DOI: 10.1042/Cs20130479 |
0.182 |
|
| 2014 |
Capdevila JH, Pidkovka N, Mei S, Gong Y, Falck JR, Imig JD, Harris RC, Wang W. The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. The Journal of Biological Chemistry. 289: 4377-86. PMID 24368771 DOI: 10.1074/Jbc.M113.508416 |
0.18 |
|
| 2013 |
Wu CC, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML. Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. Journal of the American Society of Nephrology : Jasn. 24: 1288-96. PMID 23641057 DOI: 10.1681/Asn.2012070714 |
0.18 |
|
| 2010 |
Mohapatra S, Capdevila JH, Murphy RC, Hevko JM, Falck JR. ChemInform Abstract: Efficient Total Synthesis of 5-Oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid (5-Oxo-ETE), a Potent Proinflammatory Autacoid. Cheminform. 33: no-no. DOI: 10.1002/chin.200212256 |
0.177 |
|
| 1973 |
Capdevila J, Perry AS, Morello A, Agosin M. Some spectral properties of cytochrome P-450 from microsomes isolated from control, phenobarbital- and naphthalene-treated houseflies Bba - Bioenergetics. 314: 93-103. PMID 4741599 DOI: 10.1016/0005-2728(73)90067-4 |
0.177 |
|
| 1974 |
Capdevila J, Perry AS, Agosin M. Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain Chemico-Biological Interactions. 9: 105-116. PMID 4371680 DOI: 10.1016/0009-2797(74)90003-9 |
0.176 |
|
| 2001 |
Mohapatra S, Capdevila JH, Murphy RC, Hevko JM, Falck J. Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid Tetrahedron Letters. 42: 4109-4110. DOI: 10.1016/S0040-4039(01)00668-2 |
0.173 |
|
| 2014 |
Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A. PPARα activation can help prevent and treat non-small cell lung cancer. Cancer Research. 74: 621-31. PMID 24302581 DOI: 10.1158/0008-5472.Can-13-1928 |
0.173 |
|
| 1976 |
Agosin M, Naquira C, Paulin J, Capdevila J. Cytochrome P 450 and drug metabolism in Trypanosoma cruzi: Effects of phenobarbital Science. 194: 195-197. PMID 785602 DOI: 10.1126/SCIENCE.785602 |
0.172 |
|
| 2010 |
Imig JD, Elmarakby A, Nithipatikom K, Wei S, Capdevila JH, Tuniki VR, Sangras B, Anjaiah S, Manthati VL, Sudarshan Reddy D, Falck JR. Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions. Frontiers in Physiology. 1: 157. PMID 21423396 DOI: 10.3389/Fphys.2010.00157 |
0.171 |
|
| 2017 |
Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM. Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Diabetologia. PMID 28352940 DOI: 10.1007/S00125-017-4260-0 |
0.168 |
|
| 2017 |
Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, ... ... Capdevila JH, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology. 24: 1314. PMID 29053951 DOI: 10.1016/J.Chembiol.2017.09.012 |
0.167 |
|
| 1978 |
Capdevila J, Luber RA, Prough RA. The metabolism of benzo(a)pyrene phenols by a liver microsomal phenol oxidase and quinone reductase Federation Proceedings. 37. |
0.166 |
|
| 1999 |
Chen J, Capdevila JH, Zeldin DC, Rosenberg RL. Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids. Molecular Pharmacology. 55: 288-95. PMID 9927620 DOI: 10.1124/Mol.55.2.288 |
0.166 |
|
| 2003 |
Nakagawa K, Marji JS, Schwartzman ML, Waterman MR, Capdevila JH. Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R1055-62. PMID 12531784 DOI: 10.1152/Ajpregu.00459.2002 |
0.166 |
|
| 2012 |
Capdevila J, Cervantes A, Tabernero J. New players in cancer therapeutics: Focus on inhibitors of MDM2-P53 protein-protein interaction Drugs of the Future. 37: 273-281. DOI: 10.1358/dof.2012.037.04.1769833 |
0.165 |
|
| 2004 |
Gopal V, Jagadeesh S, Reddy Y, Bandyopadhyay A, Capdevila JH, Falck J. A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs) Tetrahedron Letters. 45: 2563-2565. DOI: 10.1016/J.Tetlet.2004.01.151 |
0.165 |
|
| 1979 |
Woessner S, Lafuente R, Capdevila J, Sans-Sabrafen J. Diagnostic value of leucocytic acid-phosphatase: Isoenzymes in determining cytological types of non-lymphoid acute leukaemias Acta Haematologica. 61: 85-92. PMID 105548 DOI: 10.1159/000207637 |
0.164 |
|
| 1975 |
Capdevila J, Jernström B, Jakobsson SW, Helia O, Orrenius S. Characterization of a Rat Lung Microsomal Fraction Obtained by Sepharose 2B Ultrafiltration Cancer Research. 35: 2820-2829. PMID 808269 |
0.163 |
|
| 1983 |
Falck JR, Manna S, Capdevila J, Buynak JD. Synthesis of 14(R),15(S)- and 14(s),15(S)-dihydroxy-5,8-z-10,12-E - eicosatetraenoic acid Tetrahedron Letters. 24: 5719-5720. DOI: 10.1016/S0040-4039(00)94182-0 |
0.159 |
|
| 2013 |
Zhang MZ, Wang Y, Yao B, Gewin L, Wei S, Capdevila JH, Harris RC. Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. American Journal of Physiology. Renal Physiology. 305: F1680-6. PMID 24154693 DOI: 10.1152/ajprenal.00409.2013 |
0.158 |
|
| 2014 |
Wang WH, Zhang C, Lin DH, Wang L, Graves JP, Zeldin DC, Capdevila JH. Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect. American Journal of Physiology. Renal Physiology. 307: F453-60. PMID 24966089 DOI: 10.1152/ajprenal.00123.2014 |
0.155 |
|
| 1979 |
Prough RA, Capdevila J, Lubet RA. Metabolic activation of benzo[a]pyrene and 9-hydroxybenzo[a]pyrene by tissue fractions from rat liver and lung Biochemical Society Transactions. 7: 122-124. PMID 374148 DOI: 10.1042/bst0070122 |
0.153 |
|
| 1978 |
Capdevila J, Estabrook RW, Prough RA. The microsomal metabolism of benzo(a) pyrene phenols. Biochemical and Biophysical Research Communications. 82: 518-25. PMID 27193 DOI: 10.1016/0006-291X(78)90905-1 |
0.152 |
|
| 2006 |
Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, ... ... Capdevila JH, et al. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. The Journal of Clinical Investigation. 116: 1696-702. PMID 16691295 DOI: 10.1172/Jci27546 |
0.151 |
|
| 1973 |
Capdevila J, del Villar E, Poblete P. The effect of DDT treatment on the levels of DDT-dehydrochlorinase in Musca domestica Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 44: 441-450. PMID 4709587 DOI: 10.1016/0305-0491(73)90017-5 |
0.15 |
|
| 2008 |
Pozzi A, Capdevila JH. PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents. Ppar Research. 2008: 906542. PMID 18725983 DOI: 10.1155/2008/906542 |
0.148 |
|
| 2008 |
Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, Brown NJ. Association of a CYP4A11 variant and blood pressure in black men. Journal of the American Society of Nephrology : Jasn. 19: 1606-12. PMID 18385420 DOI: 10.1681/Asn.2008010063 |
0.147 |
|
| 1992 |
Karara A, Wei S, Spady D, Swift L, Capdevila JH, Falck JR. Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. Biochemical and Biophysical Research Communications. 182: 1320-5. PMID 1540175 DOI: 10.1016/0006-291X(92)91877-S |
0.145 |
|
| 1998 |
Helvig C, Dishman E, Capdevila JH. Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3 Biochemistry. 37: 12546-12558. PMID 9730827 DOI: 10.1021/bi981048g |
0.142 |
|
| 1979 |
Capdevila J. Quinone formation from benzo[a]pyrene during cumene hydroperoxide interaction with cytochrome P-450 (448) Boletin De Estudios Medicos Y Biologicos. 30: 271. |
0.141 |
|
| 1979 |
Capdevila J, Estabrook RW, Prough R. Quinone formation from benzo(a)pyrene during cumene hydroperoxide interaction with cytochrome P-450 (448) Federation Proceedings. 38: No. 1568. |
0.141 |
|
| 1999 |
Hasler JA, Estabrook R, Murray M, Pikuleva I, Waterman M, Capdevila J, Holla V, Helvig C, Falck JR, Farrell G, Kaminsky LS, Spivack SD, Boitier E, Beaune P. Human cytochromes P450 Molecular Aspects of Medicine. 20: 1-137. DOI: 10.1016/S0098-2997(99)00005-9 |
0.14 |
|
| 2015 |
Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Journal of the American Society of Nephrology : Jasn. 26: 597-610. PMID 25071086 DOI: 10.1681/Asn.2013090980 |
0.139 |
|
| 2003 |
Capdevila JH, Nakagawa K, Holla V. The CYP P450 arachidonate monooxygenases: enzymatic relays for the control of kidney function and blood pressure. Advances in Experimental Medicine and Biology. 525: 39-46. PMID 12751734 |
0.139 |
|
| 1980 |
Capdevila J, Estabrook RW, Prough RA. Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450. Archives of Biochemistry and Biophysics. 200: 186-95. PMID 6767447 DOI: 10.1016/0003-9861(80)90345-8 |
0.132 |
|
| 2002 |
Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. 39: 690-4. PMID 11882632 DOI: 10.1161/Hy0202.103788 |
0.128 |
|
| 1987 |
Proctor KG, Falck JR, Capdevila J. Intestinal vasodilation by epoxyeicosatrienoic acids: Arachidonic acid metabolites produced by a cytochrome P450 monooxygenase Circulation Research. 60: 50-59. PMID 3105909 DOI: 10.1161/01.Res.60.1.50 |
0.127 |
|
| 1978 |
Capdevila J, Estabrook RW, Prough RA. The existence of a benzo(a)pyrene-3,6-quinone reductase in rat liver microsomal fractions. Biochemical and Biophysical Research Communications. 83: 1291-8. PMID 697862 DOI: 10.1016/0006-291X(78)91361-X |
0.127 |
|
| 1997 |
Mullor JL, Calleja M, Capdevila J, Guerrero I. Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. Development (Cambridge, England). 124: 1227-37. PMID 9102309 |
0.123 |
|
| 2014 |
Capdevila J, Carrato A, Tabernero J, Grande E. What could Nintedanib (BIBF 1120), a triple inhibitor of VEGFR, PDGFR, and FGFR, add to the current treatment options for patients with metastatic colorectal cancer? Critical Reviews in Oncology/Hematology. 92: 83-106. PMID 24924525 DOI: 10.1016/j.critrevonc.2014.05.004 |
0.121 |
|
| 1995 |
Capdevila JM. Teodoro Lazaro Annals of Vascular Surgery. 9: 134. DOI: 10.1007/BF02015328 |
0.12 |
|
| 2000 |
Falck J, Krishna U, Katipally KR, Capdevila JH, Ulug ET. Concise syntheses of l-α-phosphatidyl-d-myo-inositol 3-phosphate (3-PIP), 5-phosphate (5-PIP), and 3,5-bisphosphate (3,5-PIP2) Tetrahedron Letters. 41: 4271-4275. DOI: 10.1016/S0040-4039(00)00465-2 |
0.12 |
|
| 2015 |
Alonso-Gordoa T, Capdevila J, Grande E. Biotherapy for neuroendocrine tumours European Journal of Endocrinology. 172: R31-R46. PMID 25430657 DOI: 10.1530/EJE-14-0354 |
0.12 |
|
| 2001 |
Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proceedings of the National Academy of Sciences of the United States of America. 98: 5211-6. PMID 11320253 DOI: 10.1073/Pnas.081627898 |
0.118 |
|
| 2010 |
Falck JR, Kumar PS, Reddy YK, Zou G, Capdevila JH. ChemInform Abstract: Stereospecific Synthesis of EET Metabolites via Suzuki-Miyaura Coupling. Cheminform. 33: no-no. DOI: 10.1002/chin.200201235 |
0.116 |
|
| 2015 |
Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML. Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R71-8. PMID 25924878 DOI: 10.1152/Ajpregu.00039.2015 |
0.116 |
|
| 1994 |
Chauhan K, Bhatt RK, Falck J, Capdevila JH. Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues Tetrahedron Letters. 35: 1825-1828. DOI: 10.1016/S0040-4039(00)73170-4 |
0.113 |
|
| 1999 |
Chen J, Falck JR, Capdevila JH, Harris RC. cP450 Epoxygenase exerts potent cytoprotective effects by a dual mechanism in renal epithelial cells Prostaglandins & Other Lipid Mediators. 59: 95. DOI: 10.1016/S0090-6980(99)90330-1 |
0.111 |
|
| 2002 |
Yu J, Lai J, Ye J, Balu N, Reddy L, Duan W, Fogel ER, Capdevila JH, Falck J. Chiral cyclopropanes: asymmetric synthesis of constanolactones A and B Tetrahedron Letters. 43: 3939-3941. DOI: 10.1016/S0040-4039(02)00699-8 |
0.109 |
|
| 2007 |
Capdevila JH. Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Current Opinion in Nephrology and Hypertension. 16: 465-70. PMID 17693763 DOI: 10.1097/MNH.0b013e32827ab48c |
0.108 |
|
| 1998 |
Zapata A, Capdevila JL, Trullas R. Region-specific and calcium-dependent increase in dialysate choline levels by NMDA. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3597-605. PMID 9570791 DOI: 10.1523/Jneurosci.18-10-03597.1998 |
0.106 |
|
| 1997 |
Reddy K, Ye J, Falck J, Capdevila JH. Intracellular second messengers: Synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate and analogs Bioorganic & Medicinal Chemistry Letters. 7: 2115-2116. DOI: 10.1016/S0960-894X(97)00370-3 |
0.105 |
|
| 2007 |
Falck JR, Sangras B, Capdevila JH. Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks. Bioorganic & Medicinal Chemistry. 15: 1062-6. PMID 17070060 DOI: 10.1016/J.Bmc.2006.10.022 |
0.104 |
|
| 2000 |
Falck JR, Krishna UM, Capdevila JH. Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2). Bioorganic & Medicinal Chemistry Letters. 10: 1711-3. PMID 10937730 DOI: 10.1016/S0960-894X(00)00315-2 |
0.104 |
|
| 2009 |
Capdevila J, Salazar R. Molecular targeted therapies in the treatment of gastroenteropancreatic neuroendocrine tumors Targeted Oncology. 4: 287-296. PMID 19898923 DOI: 10.1007/s11523-009-0128-7 |
0.102 |
|
| 1996 |
Brosa C, Capdevila JM, Zamora I. Brassinosteroids: A new way to define the structural requirements Tetrahedron. 52: 2435-2448. DOI: 10.1016/0040-4020(95)01065-3 |
0.102 |
|
| 2010 |
CHAUHAN K, BHATT RK, FALCK JR, CAPDEVILA JH. ChemInform Abstract: Total Synthesis of the Ethanol-Inducible, Proinflammatory Autacoid 3(S) -Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues. Cheminform. 25: no-no. DOI: 10.1002/chin.199430238 |
0.1 |
|
| 2009 |
Quigley R, Chakravarty S, Zhao X, Imig JD, Capdevila JH. Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice. Nephron. Physiology. 113: p23-8. PMID 19713718 DOI: 10.1159/000235774 |
0.099 |
|
| 2010 |
Falck JR, Krishna UM, Capdevila JH. ChemInform Abstract: A Synthesis of L-α-Phosphatidyl-D-myo-inositol 4,5-Bisphosphate (4,5-PIP2) and Glyceryl Lipid Analogues. Cheminform. 31: no-no. DOI: 10.1002/chin.200008251 |
0.099 |
|
| 2003 |
Barma DK, Bandyopadhyay A, Capdevila JH, Falck JR. Dimethylthiocarbamate (DMTC): an alcohol protecting group. Organic Letters. 5: 4755-7. PMID 14653666 DOI: 10.1021/Ol0354573 |
0.098 |
|
| 2017 |
Hashimoto R, Joshi SR, Jiang H, Capdevila JH, McMurtry IF, Laniado Schwartzman M, Gupte SA. Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: Implication in chronic hypoxia-induced pulmonary hypertension. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00785.2016. PMID 28550179 DOI: 10.1152/Ajpheart.00785.2016 |
0.096 |
|
| 1996 |
Sánchez-Herrero E, Couso JP, Capdevila J, Guerrero I. The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mechanisms of Development. 55: 159-70. PMID 8861096 DOI: 10.1016/0925-4773(96)00498-4 |
0.096 |
|
| 2010 |
REDDY KK, FALCK JR, CAPDEVILA J. ChemInform Abstract: Insulin Second Messengers: Synthesis of 6-O-(2-Amino-2-deoxy-α-D- glucopyranosyl)-D-chiro-inositol-1-phosphate. Cheminform. 25: no-no. DOI: 10.1002/chin.199414271 |
0.094 |
|
| 1998 |
Capdevila J, Johnson RL. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning Developmental Biology. 197: 205-217. PMID 9630747 DOI: 10.1006/dbio.1997.8824 |
0.093 |
|
| 2014 |
Stjepanovic N, Capdevila J. Multikinase inhibitors in the treatment of thyroid cancer: Specific role of lenvatinib Biologics: Targets and Therapy. 8: 129-139. DOI: 10.2147/BTT.S39381 |
0.09 |
|
| 1999 |
Capdevila J, Belmonte JCI. Extracellular modulation of the hedgehog, Wnt and TGF-β signalling pathways during embryonic development Current Opinion in Genetics and Development. 9: 427-433. PMID 10449357 DOI: 10.1016/S0959-437X(99)80065-3 |
0.089 |
|
| 2009 |
Markman B, Capdevila J, Elez E, Tabernero J. New trends in epidermal growth factor receptor-directed monoclonal antibodies Immunotherapy. 1: 965-982. PMID 20635913 DOI: 10.2217/imt.09.66 |
0.089 |
|
| 2012 |
Capdevila J, Argilés G, Mulet-Margalef N, Tabernero J. Neuroendocrine tumors: The age of targeted therapies Endocrinologia Y Nutricion. 59: 438-451. PMID 22565119 DOI: 10.1016/j.endonu.2012.03.003 |
0.087 |
|
| 1994 |
Capdevila J, Guerrero I. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. The Embo Journal. 13: 4459-68. PMID 7925288 DOI: 10.1002/J.1460-2075.1994.Tb06768.X |
0.085 |
|
| 2001 |
Rodríguez-Esteban C, Capdevila J, Kawakami Y, Belmonte JCI. Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo Development. 128: 3189-3195. PMID 11688567 |
0.085 |
|
| 2010 |
Yu J, Lai J, Ye J, Balu N, Reddy LM, Duan W, Fogel ER, Capdevila JH, Falck JR. ChemInform Abstract: Chiral Cyclopropanes: Asymmetric Synthesis of Constanolactones A and B. Cheminform. 33: no-no. DOI: 10.1002/chin.200236218 |
0.082 |
|
| 2010 |
Falck JR, Krishna UM, Katipally KR, Capdevila JH, Ulug ET. ChemInform Abstract: Concise Syntheses of L-α-phosphatidyl-D-myo-inositol 3-Phosphate (3-PIP), 5-Phosphate (5-PIP), and 3,5-Bisphosphate (3,5-PIP2). Cheminform. 31: no-no. DOI: 10.1002/chin.200034196 |
0.082 |
|
| 2018 |
Gilani A, Pandey V, Garcia V, Agostinucci K, Singh SP, Schragenheim J, Bellner L, Falck JR, Paudyal MP, Capdevila JH, Abraham NG, Laniado Schwartzman M. HIGH FAT DIET-INDUCED OBESITY AND INSULIN RESISTANCE IN CYP4A14 MICE IS MEDIATED BY 20-HETE. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 30088983 DOI: 10.1152/Ajpregu.00125.2018 |
0.081 |
|
| 1998 |
Capdevila J, Tabin C, Johnson RL. Control of dorsoventral somite patterning by Wnt-1 and β-catenin Developmental Biology. 193: 182-194. PMID 9473323 DOI: 10.1006/Dbio.1997.8806 |
0.079 |
|
| 2003 |
Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Archives of Biochemistry and Biophysics. 409: 221-7. PMID 12464262 DOI: 10.1016/S0003-9861(02)00545-3 |
0.078 |
|
| 2016 |
Joshi SR, Lakhkar A, Dhagia V, Zias AL, Soldatos V, Oshima K, Jiang H, Gotlinger K, Capdevila JH, Schwartzman ML, McMurtry IF, Gupte SA. Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice. Pulmonary Circulation. 6: 360-8. PMID 27683613 DOI: 10.1086/688060 |
0.078 |
|
| 1994 |
Rodriguez Hierro F, Capdevila J, Pavia C, Valls C. Final height and precocious puberty Endocrinologia. 41: 31-34. |
0.074 |
|
| 2013 |
Salvà F, Capdevila J. New molecular targets and lines of research in thyroid cancer Revisiones En Cancer. 27: 86-97. |
0.07 |
|
| 1994 |
Capdevila J, Pariente F, Sampedro J, Alonso JL, Guerrero I. Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development (Cambridge, England). 120: 987-98. PMID 7600973 |
0.07 |
|
| 2009 |
Capdevila J, Perez-Garcia J, Obiols G, Tabernero J. Targeted therapies in thyroid cancer Targeted Oncology. 4: 275-285. PMID 19904500 DOI: 10.1007/s11523-009-0124-y |
0.07 |
|
| 2008 |
Ramos FJ, Macarulla T, Capdevila J, Elez E, Tabernero J. Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer. Clinical Colorectal Cancer. 7: S52-7. PMID 19064407 DOI: 10.3816/CCC.2008.s.008 |
0.067 |
|
| 2003 |
Capdevila J, Belmonte JCI. Control of Left-Right (L/R) Determination in Vertebrates by the Hedgehog Signaling Pathway Handbook of Cell Signaling. 2: 799-803. DOI: 10.1016/B978-012124546-7/50615-X |
0.066 |
|
| 2001 |
Capdevila J, Belmonte JCI. Patterning mechanisms controlling vertebrate limb development Annual Review of Cell and Developmental Biology. 17: 87-132. PMID 11687485 DOI: 10.1146/annurev.cellbio.17.1.87 |
0.065 |
|
| 2000 |
Capdevila J, Vogan KJ, Tabin CJ, Izpisúa Belmonte JC. Mechanisms of left-right determination in vertebrates. Cell. 101: 9-21. PMID 10778851 DOI: 10.1016/S0092-8674(00)80619-4 |
0.064 |
|
| 1974 |
Ocon J, Capdevila JM, Forteza J. Phaeochromocytoma associated with renal artery dysplasia Revista Clinica Espanola. 133: 65-70. PMID 4840255 |
0.062 |
|
| 2003 |
Bellamine A, Wang Y, Waterman MR, Gainer III JV, Dawson EP, Brown NJ, Capdevila JH. Erratum to “Characterization of the CYP4A11 gene, a second CYP4A gene in humans” [Arch. Biochem. Biophys. 409 (2003) 221–227] Archives of Biochemistry and Biophysics. 412: 153. DOI: 10.1016/S0003-9861(03)00066-3 |
0.06 |
|
| 2010 |
Capdevila JA, Icart R. Malaria prophylaxis in the traveler Revista Clinica Espanola. 210: 77-83. PMID 20144809 DOI: 10.1016/j.rce.2009.06.014 |
0.059 |
|
| 1994 |
Capdevila J, Estrada MP, Sánchez-Herrero E, Guerrero I. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. The Embo Journal. 13: 71-82. PMID 8306973 DOI: 10.1002/J.1460-2075.1994.Tb06236.X |
0.058 |
|
| 1974 |
Epeldegui A, Bongera F, Capdevila JM. Renal artery dysplasia associated with pheochromocytoma as the cause of arterial hypertension Angiologia. 26: 268-271. PMID 4440903 |
0.058 |
|
| 2013 |
Grande E, Capdevila J, Díez JJ, Longo F, Carrato A. A significant response to sunitinib in a patient with anaplastic thyroid carcinoma Journal of Research in Medical Sciences. 18: 622-624. |
0.051 |
|
| 2000 |
Saurel N, Capdevila JM, Huot N. Tomography applied to actinides detection by photofission Ieee Nuclear Science Symposium and Medical Imaging Conference. 3. |
0.051 |
|
| 2010 |
Macarulla T, Capdevila J, Tabernero J. New approaches in systemic treatment of advanced biliary tract cancers: The molecular era Cancer and Chemotherapy Reviews. 5: 195-201. |
0.05 |
|
| 2003 |
Mohapatra S, Bandyopadhyay A, Barma DK, Capdevila JH, Falck JR. Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling. Organic Letters. 5: 4759-62. PMID 14653667 DOI: 10.1021/Ol035458V |
0.05 |
|
| 2011 |
Capdevila J, Tabernero J. A shining light in the darkness for the treatment of pancreatic neuroendocrine tumors Cancer Discovery. 1: 213-221. PMID 22586573 DOI: 10.1158/2159-8290.CD-11-0151 |
0.05 |
|
| 1993 |
Palomar M, Capdevila JA, Planes AM. Usefulness of quantitative of blood culture in the diagnosis of catheter-related sepsis Medicina Intensiva. 17: 559-562. |
0.05 |
|
| 2000 |
Capdevila J, Johnson RL. Hedgehog signaling in vertebrate and invertebrate limb patterning Cellular and Molecular Life Sciences. 57: 1682-1694. PMID 11130175 DOI: 10.1007/PL00000651 |
0.049 |
|
| 2010 |
Markman B, Javier Ramos F, Capdevila J, Tabernero J. EGFR and KRAS in Colorectal Cancer Advances in Clinical Chemistry. 51: 71-119. PMID 20857619 DOI: 10.1016/S0065-2423(10)51004-7 |
0.049 |
|
| 2008 |
Macarulla T, Ramos FJ, Capdevila J, Elez ME, Tabernero J. A 48-year-old woman with metastatic colon cancer and complete pathological response after treatment with chemotherapy and cetuximab American Journal of Hematology/ Oncology. 7. |
0.049 |
|
| 1999 |
Gmar M, Capdevila JM. Use of delayed gamma spectra for detection of actinides (U,Pu) by photofission Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 422: 841-845. DOI: 10.1016/S0168-9002(98)01121-8 |
0.048 |
|
| 2000 |
Capdevila J, Belmonte JCI. Knowing left from right: The molecular basis of laterality defects Molecular Medicine Today. 6: 112. PMID 10689314 DOI: 10.1016/S1357-4310(00)01671-3 |
0.048 |
|
| 2000 |
Capdevila J, Belmonte JCI. Perspectives on the evolutionary origin of tetrapod limbs Journal of Experimental Zoology. 288: 287-303. PMID 11144278 DOI: 10.1002/1097-010X(20001215)288:4<287::AID-JEZ2>3.0.CO;2-5 |
0.047 |
|
| 2002 |
Tallec M, Capdevila JM. Storage of ILLW: What problems? Where? Comptes Rendus Physique. 3: 851-866. DOI: 10.1016/S1631-0705(02)01369-5 |
0.047 |
|
| 2008 |
Capdevila J, Tabernero J, Köhne CH. Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy Advances in Gastrointestinal Cancers. 6: 12-13. |
0.047 |
|
| 1962 |
FARRERAS VALENTI P, ROZMAN C, CAPDEVILA J, WOESSNER S. Increase of fetal hemoglobin in aplastic anemia Revista ClíNica EspañOla. 87: 94-97. PMID 13944459 |
0.047 |
|
| 2011 |
Braña I, Dienstmann R, Capdevila J, Tabernero J. Drugs in clinical trials Advances in the Pharmacological Management of Metastatic Colorectal Cancer. 42-54. DOI: 10.2217/EBO.11.4 |
0.046 |
|
| 2012 |
Mulet-Margalef N, Capdevila J. Epidemiology of neuroendocrine tumors Revisiones En Cancer. 26: 1-6. |
0.041 |
|
| 2000 |
Camps AJ, Corbella I, Torres F, Bara J, Capdevila J. RF interference analysis in aperture synthesis interferometric radiometers: application to L-band MIRAS instrument Ieee Transactions On Geoscience and Remote Sensing. 38: 942-950. DOI: 10.1109/36.841976 |
0.037 |
|
| 1961 |
GRAS J, CAPDEVILA J. Blood mucoproteins. I. Technic of determination and normal values Revista EspañOla De FisiologíA. 17: 73-79. PMID 13901183 |
0.035 |
|
| 2009 |
Capdevila J, Ramos FJ, Macarulla T, Elez E, Tabernero J. The role of salvage treatment in advanced colorectal cancer. Critical Reviews in Oncology/Hematology. 71: 53-61. PMID 18977669 DOI: 10.1016/j.critrevonc.2008.09.006 |
0.035 |
|
| 2013 |
Capdevila JA. Use of peripheral catheters: Too much to learn Revista Espanola De Quimioterapia. 26: 1-5. PMID 23546455 |
0.035 |
|
| 2014 |
Trigo JM, Capdevila J, Grande E, Grau J, Lianes P. Thyroid cancer: SEOM clinical guidelines. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 16: 1035-42. PMID 25245079 DOI: 10.1007/s12094-014-1224-4 |
0.034 |
|
| 2014 |
Rovira C, Capdevila J, Marcos MC. The importance of sources in the selection of online newspaper articles: A study of Google News using eye-tracking Investigacion Bibliotecologica. 28: 15-28. |
0.034 |
|
| 2006 |
Capdevila J, Maroto P, Sainz S, Villavicencio H. Disseminated retroperitoneal choriocarcinoma with open fistula to intestine. «Restitutio ad integrum» with chemotherapy alone Clinical and Translational Oncology. 8: 453-455. PMID 16790400 DOI: 10.1007/s12094-006-0201-y |
0.032 |
|
| 2001 |
Frasier SJ, Carswell JR, Capdevila J. A pod-based dual-beam interferometric radar for ocean surface current vector mapping International Geoscience and Remote Sensing Symposium (Igarss). 1: 561-563. |
0.032 |
|
| 2009 |
Garcia MJ, Capdevila JM. Attitude and speed in young people. Implementation of a program of driver education Relieve - Revista Electronica De Investigacion Y Evaluacion Educativa. 15: 1-28. |
0.032 |
|
| 2015 |
Capdevila JA, Rinaldi VA. Stress-strain behavior of a heterogeneous and lightly cemented soil under triaxial compression test Electronic Journal of Geotechnical Engineering. 20: 6745-6760. |
0.031 |
|
| 2004 |
Mohapatra S, Bandyopadhyay A, Barma DK, Capdevila JH, Falck JR. Chiral α,β-Dialkoxy- and α-Alkoxy-β-aminostannanes: Preparation and Copper-Mediated Cross-Coupling. Cheminform. 35. DOI: 10.1002/chin.200416154 |
0.029 |
|
| 2015 |
Capdevila J, Cerquides J, Nin J, Torres J. Tweet-SCAN: An event discovery technique for geo-located tweets Frontiers in Artificial Intelligence and Applications. 277: 110-119. DOI: 10.3233/978-1-61499-578-4-110 |
0.029 |
|
| 1997 |
Capdevila JA. Current methods for the diagnosis of catheter-related bacteraemia Reviews in Medical Microbiology. 8: 189-195. |
0.029 |
|
| 2013 |
Rinaldi VA, Capdevila JA. Sampling effect in a structured collapsible soil Geotechnical and Geophysical Site Characterization 4 - Proceedings of the 4th International Conference On Site Characterization 4, Isc-4. 2: 1559-1563. |
0.029 |
|
| 1963 |
VILANOVA X, RUEDA LA, CAPDEVILA JM. NEW HISTOLOGIC VARIETY OF KERATOACANTHOMA. THE DYSKERATOSIC KERATOACANTHOMA Actas Dermo-SifiliográFicas. 54: 200-207. PMID 14078709 |
0.028 |
|
| 1974 |
Capdevila JM, Bongera F, Estevan J. Acute ischemia of the mesenteric and celiac arteries Mediterranee Medicale. 2: 89-107. |
0.028 |
|
| 1957 |
VILANOVA X, CARDENAL C, CAPDEVILA JM. Not Available Actas Dermo-SifiliográFicas. 48: 221-229. PMID 13435026 |
0.028 |
|
| 2006 |
Rinaldi VA, Capdevila JA. Effect of cement and saturation on the stress-strain behavior of a silty clay Geotechnical Special Publication. 1157-1168. DOI: 10.1061/40802(189)94 |
0.027 |
|
| 1966 |
Rozman C, Capdevila J, Woessner S, Martí I. Hemoglobinosis H (alpha-thalassemia) in a Spanish family Revista Clinica Espanola. 103: 373-377. PMID 5999021 |
0.026 |
|
| 2010 |
Sabatés LA, Capdevila JM. Aportaciones sobre la relación conceptual entre actitud y competencia, desde la teoría del cambio de actitudes Electronic Journal of Research in Educational Psychology. 8: 1283-1302. |
0.025 |
|
| 2009 |
Rinaldi VA, Capdevila JA. Effect of sampling disturbance on the stress strain behavior of a structured collapsible soil Proceedings of the 17th International Conference On Soil Mechanics and Geotechnical Engineering: the Academia and Practice of Geotechnical Engineering. 1: 837-840. DOI: 10.3233/978-1-60750-031-5-837 |
0.025 |
|
| 1965 |
Vilanova X, Capdevila JM. Association of the Paget's epithelioma and palmo-plantar keratoderma (Mantoux type). Chronic arsenism? Actas Dermo-Sifiliograficas. 56: 337-338. PMID 4225165 |
0.024 |
|
| 2016 |
Capdevila J, Arias M, Arratia A. GeoSRS: A hybrid social recommender system for geolocated data Information Systems. 57: 111-128. DOI: 10.1016/J.Is.2015.10.003 |
0.023 |
|
| 2012 |
Trufero JM, Capdevila J, Cruz JJ, Isla D. In answer to: "comments to SEOM clinical guidelines for the treatment of thyroid cancer" by Garcilaso Riesco-Eizaguirre et al Clinical and Translational Oncology. 14: 711-712. DOI: 10.1007/s12094-012-0918-8 |
0.023 |
|
| 2014 |
Capdevila J, Weber M, Pape UF. Continued advances in targeting gastroenteropancreatic neuroendocrine tumors: general discussion. Clinical Advances in Hematology & Oncology : H&O. 12: 22; quiz 23. PMID 25768107 |
0.023 |
|
| 1998 |
Capdevila JA. Catheter-related infection: An update on diagnosis, treatment, and prevention International Journal of Infectious Diseases. 2: 230-236. PMID 9763507 DOI: 10.1016/S1201-9712(98)90059-5 |
0.022 |
|
| 2012 |
Capdevila JM. We have lost another ex-Chairman: Emili Viver Angiologia. 64: 146. DOI: 10.1016/j.angio.2012.04.001 |
0.021 |
|
| 1952 |
VILANOVA X, PINOL J, CAPDEVILA JM. Erythroderma caused by a thiosemicarbazone Actas Dermo-SifiliográFicas. 43: 826-827. PMID 12985476 |
0.021 |
|
| 1973 |
Pinol Aguade J, Capdevila JM, Lecha M. Seckel's syndrome with manifestations of photosensitivity Med.Cutanea Ibero Lat.Am.. 7: 327-331. |
0.02 |
|
| 1974 |
Capdevila JM, Alemany JA, Bongera F. XX Spanish Conference on Angiology, Santander 1974. Round table on complications of arteriography and direct arterial surgery Angiologia. 26: 245-260. PMID 4440900 |
0.02 |
|
| 2002 |
Capdevila JA. How to manage central venous catheter-related sepsis Clinical Nutrition. 21: 195-197. PMID 12127926 DOI: 10.1054/clnu.2002.0552 |
0.019 |
|
| 1983 |
Castaño Santa J, Capdevila JM. Cerebral protection in supra-aortic vessel surgery: up-date and introduction of a new method Revista Espanola De Anestesiologia Y Reanimacion. 30: 166-173. PMID 6422523 |
0.019 |
|
| 1955 |
VILANOVA X, CARDENAL C, CAPDEVILA JM. Disseminated miliary tuberculosis of the face: disseminated follicular lupus of Tilbury Fos; miliary lupoid; miliary lupus of the face Actas Dermo-SifiliográFicas. 46: 262-266. PMID 14376205 |
0.017 |
|
| 2011 |
Capdevila J, Díez Miranda I, Obiols G, Tabernero J. Control of carcinoid syndrome with everolimus Annals of Oncology. 22: 237-239. PMID 21169474 DOI: 10.1093/annonc/mdq670 |
0.016 |
|
| 2014 |
Capdevila J. Clinical scenario 1: Advanced, grade 2, neuroendocrine tumor in the midgut Clinical Advances in Hematology and Oncology. 12: 17-19. PMID 25768105 |
0.016 |
|
| 1989 |
Capdevila JM. Round table on the current status of vascular surgery Angiologia. 41: 69-74. PMID 2729653 |
0.015 |
|
| 1964 |
CAPDEVILA JM, GONZALEZHERMOSO F, BONJERACAMPOMANES F. PARCHMENT ANGIOPLASTY IN VASCULAR SURGERY Cirugía, Ginecología Y UrologíA. 18: 415-423. PMID 14286203 |
0.014 |
|
| 1956 |
CAPDEVILA JM, CARDENAL C, VILANOVA X. Generalized zoster Actas Dermo-SifiliográFicas. 47: 629-635. PMID 13354501 |
0.013 |
|
| 1995 |
Capdevila JA, Pahissa A. Defence mechanisms against meningococcus Medicina Clinica. 105: 94-95. PMID 7603118 |
0.013 |
|
| 1959 |
VILANOVA X, CAPDEVILA JM. Statistical study of 141 cases of strophulus examined in the Actas Dermo-SifiliográFicas. 50: 357-360. PMID 13842246 |
0.012 |
|
| 1974 |
Gutiérrez JM, Bongera F, Capdevila JM. Gluteal angioma caused by arteriovenous fistula Angiologia. 26: 261-264. PMID 4440901 |
0.012 |
|
| 1956 |
CAPDEVILA JM, CARDENAL C, VILANOVA X. Suppurant bubo and syphilitic edema Actas Dermo-SifiliográFicas. 47. PMID 13381605 |
0.012 |
|
| 2007 |
Macarulla T, Capdevila J, Ramos FJ, Saura C, Tabernero J. Medical treatment Gastroenterologia Y Hepatologia Continuada. 6: 174-179. DOI: 10.1016/S1578-1550(07)75673-5 |
0.01 |
|
| 2005 |
Reth Fuster P, Fernàndez X, Capdevila JA. Legionellosis Fmc Formacion Medica Continuada En Atencion Primaria. 12: 213-219. DOI: 10.1016/S1134-2072(05)75191-4 |
0.01 |
|
| 1999 |
Capdevila JA. Diagnosis of catheter infection Enfermedades Infecciosas Y Microbiología ClíNica. 17: 105-107. PMID 10193080 |
0.01 |
|
| 1997 |
Capdevila JA, Pahissa A. Infeectious prophylaxis in neutropenic patients Enfermedades Infecciosas Y Microbiologia Clinica. 15: 544-551. PMID 9522519 |
0.01 |
|
| 1997 |
Almirante B, Capdevila JA. Empirical treatment of acute purulent meningitis International Journal of Infectious Diseases. 1: 179-181. DOI: 10.1016/S1201-9712(97)90032-1 |
0.01 |
|
| 1996 |
Saballs M, Ruiz I, Capdevila JA. Cavitated pulmonary nodules in a patient with HIV infection Enfermedades Infecciosas Y Microbiologia Clinica. 14: 563-564. PMID 9035716 |
0.01 |
|
| 1996 |
Gavalda J, Capdevila JA. Enterococcal spondylodiskitis [7] Clinical Infectious Diseases. 22: 1135. PMID 8783745 |
0.01 |
|
| 1990 |
Armengol P, Capdevila JM, Mascaró JM. Antimicrobial sensitivity, auxotype, serotype and plasmid analysis of 75 strains of Neisseria gonorrhoeae isolated in Barcelona Medicina Clinica. 94: 156. PMID 2109159 |
0.01 |
|
| 1979 |
Torras H, Capdevila JM, Singla R. A case for diagnosis (insect bite) Revista De Leprologia (Fontilles). 12: 303-306. |
0.01 |
|
| 1976 |
Morel CJ, Filippin DM, Rapela RO, Capdevila J. Therapeutic experience in acute pancreatitis Revista Argentina De Cirugia. 31: 89-90. |
0.01 |
|
| 1974 |
Segura R, Bongera F, Capdevila JM. An unusual case of repetitive mycotic aneurysm Angiologia. 26: 276-280. PMID 4479932 |
0.01 |
|
| 1974 |
Ferrando J, Capdevila JM, Pinol Aguade J. Xanthoerythrodermia perstans or digitate dermatosis (benign squamous parapsoriasis) Actas Dermo-Sifiliograficas. 65: 177-178. PMID 4451180 |
0.01 |
|
| 1974 |
Luque MM, Bongera F, Capdevila JM. Combined surgery of extensive iliofemoral-popliteal lesions Angiologia. 26: 302-305. PMID 4440911 |
0.01 |
|
| 1973 |
Capdevila JM, Pedragosa R. Pityriasis rubra pilaris with pseudoainhum Actas Dermo-Sifiliograficas. 64: 245-248. PMID 4841009 |
0.01 |
|
| 1973 |
Capdevila JM. Acute mesenteric obstructions Journal of Cardiovascular Surgery. 5-7. PMID 4806899 |
0.01 |
|
| 1973 |
Capdevila JM, Bongera F, Luque MM. Aorto-iliac endarterectomy: A review of 249 operations Journal of Cardiovascular Surgery. 34-37. PMID 4806866 |
0.01 |
|
| 1973 |
Castells Rodellas A, Castel T, Capdevila JM. Immunofluorescence of lichen planus Med.Cutanea Ibero Lat.Am.. 49-55. |
0.01 |
|
| 1965 |
Vilanova X, Capdevila JM. Statistics on syphilis cases observed for the first time in the dermatologic clinic of the University of Barcelona in 1963-1964 Actas Dermo-Sifiliograficas. 56: 329-332. PMID 5874754 |
0.01 |
|
| 1958 |
VILANOVA X, CARDENAL C, CAPDEVILA JM. Single recurrence: a case of redux chancre after penicillin therapy Actas Dermo-SifiliográFicas. 49: 221-225. PMID 13571013 |
0.01 |
|
| 1956 |
CAPDEVILA JM, CARDENAL C, VILANOVA X. [Chronic lupus erythematosus of conjunctiva] Dermatologica. 113: 226-231. PMID 13384068 |
0.01 |
|
| 1953 |
VILANOVA X, PINOL J, CAPDEVILA JM. Pseudotabes due to funicular myelosis in a patient with syphilis and pernicious anemia Actas Dermo-SifiliográFicas. 44: 381-383. PMID 13079999 |
0.01 |
|
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