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David S. Ragsdale - Publications

Affiliations: 
Neurology and Neurosurgery McGill University, Montreal, QC, Canada 
Area:
Sodium Channels, Calcium Channels, Epilepsy
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lévesque M, Ragsdale D, Avoli M. Evolving Mechanistic Concepts Of Epileptiform Synchronization And Their Relevance In Curing Focal Epileptic Disorders. Current Neuropharmacology. PMID 30479217 DOI: 10.2174/1570159X17666181127124803  0.347
2011 Mo G, Grant R, O'Donnell D, Ragsdale DS, Cao CQ, Séguéla P. Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C. Molecular Pain. 7: 14. PMID 21314936 DOI: 10.1186/1744-8069-7-14  0.47
2010 Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. The Lancet. Neurology. 9: 413-24. PMID 20298965 DOI: 10.1016/S1474-4422(10)70059-4  0.625
2008 Ragsdale DS. How do mutant Nav1.1 sodium channels cause epilepsy? Brain Research Reviews. 58: 149-59. PMID 18342948 DOI: 10.1016/J.Brainresrev.2008.01.003  0.539
2005 Wang X, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents. Biophysical Journal. 89: 1731-43. PMID 15980164 DOI: 10.1529/Biophysj.104.058875  0.344
2005 Lucas PT, Meadows LS, Nicholls J, Ragsdale DS. An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin. Epilepsy Research. 64: 77-84. PMID 15922564 DOI: 10.1016/J.Eplepsyres.2005.03.003  0.653
2004 Huang L, Keyser BM, Tagmose TM, Hansen JB, Taylor JT, Zhuang H, Zhang M, Ragsdale DS, Li M. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. The Journal of Pharmacology and Experimental Therapeutics. 309: 193-9. PMID 14718587 DOI: 10.1124/jpet.103.060814  0.369
2003 Agrawal N, Alonso A, Ragsdale DS. Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy. Epilepsia. 44: 1601-4. PMID 14636336 DOI: 10.1111/J.0013-9580.2003.23103.X  0.606
2003 Magistretti J, Ragsdale DS, Alonso A. Kinetic diversity of single-channel burst openings underlying persistent Na(+) current in entorhinal cortex neurons. Biophysical Journal. 85: 3019-34. PMID 14581203 DOI: 10.1016/S0006-3495(03)74721-3  0.615
2003 De Leon L, Ragsdale DS. State-dependent access to the batrachotoxin receptor on the sodium channel. Neuroreport. 14: 1353-6. PMID 12876472 DOI: 10.1097/01.wnr.0000077552.91466.08  0.47
2003 Cossette P, Loukas A, Lafrenière RG, Rochefort D, Harvey-Girard E, Ragsdale DS, Dunn RJ, Rouleau GA. Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). Epilepsy Research. 53: 107-17. PMID 12576172 DOI: 10.1016/S0920-1211(02)00259-0  0.559
2002 Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen-Gillespie KA, Koopman MC, Kriegler S, Isom LL, Ragsdale DS. Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10699-709. PMID 12486163 DOI: 10.1523/Jneurosci.22-24-10699.2002  0.733
2002 Meadows LS, Chen YH, Powell AJ, Clare JJ, Ragsdale DS. Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits. Neuroscience. 114: 745-53. PMID 12220575 DOI: 10.1016/S0306-4522(02)00242-7  0.603
2002 Li HL, Hadid D, Ragsdale DS. The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate. Molecular Pharmacology. 61: 905-12. PMID 11901230 DOI: 10.1124/Mol.61.4.905  0.588
2001 Meadows L, Malhotra JD, Stetzer A, Isom LL, Ragsdale DS. The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. Journal of Neurochemistry. 76: 1871-8. PMID 11259505 DOI: 10.1046/J.1471-4159.2001.00192.X  0.726
2001 Agrawal N, Hamam BN, Magistretti J, Alonso A, Ragsdale DS. Persistent sodium channel activity mediates subthreshold membrane potential oscillations and low-threshold spikes in rat entorhinal cortex layer V neurons. Neuroscience. 102: 53-64. PMID 11226669 DOI: 10.1016/S0306-4522(00)00455-3  0.645
2000 Kazen-Gillespie KA, Ragsdale DS, D'Andrea MR, Mattei LN, Rogers KE, Isom LL. Cloning, localization, and functional expression of sodium channel beta1A subunits. The Journal of Biological Chemistry. 275: 1079-88. PMID 10625649 DOI: 10.1074/Jbc.275.2.1079  0.691
1999 Magistretti J, Ragsdale DS, Alonso A. Direct demonstration of persistent Na+ channel activity in dendritic processes of mammalian cortical neurones. The Journal of Physiology. 521: 629-36. PMID 10601494 DOI: 10.1111/J.1469-7793.1999.00629.X  0.716
1999 Xiao ZC, Ragsdale DS, Malhotra JD, Mattei LN, Braun PE, Schachner M, Isom LL. Tenascin-R is a functional modulator of sodium channel beta subunits. The Journal of Biological Chemistry. 274: 26511-7. PMID 10473612 DOI: 10.1074/Jbc.274.37.26511  0.713
1999 Magistretti J, Ragsdale DS, Alonso A. High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7334-41. PMID 10460240  0.532
1999 Li HL, Galue A, Meadows L, Ragsdale DS. A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel. Molecular Pharmacology. 55: 134-41. PMID 9882707 DOI: 10.1124/Mol.55.1.134  0.517
1999 Magistretti J, Ragsdale DS, Alonso A. High Conductance Sustained Single-Channel Activity Responsible for the Low-Threshold Persistent Na+ Current in Entorhinal Cortex Neurons The Journal of Neuroscience. 19: 7334-7341. DOI: 10.1523/Jneurosci.19-17-07334.1999  0.72
1998 Ragsdale DS, Avoli M. Sodium channels as molecular targets for antiepileptic drugs. Brain Research. Brain Research Reviews. 26: 16-28. PMID 9600622 DOI: 10.1016/S0165-0173(97)00054-4  0.581
1998 McCormick KA, Isom LL, Ragsdale D, Smith D, Scheuer T, Catterall WA. Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit. The Journal of Biological Chemistry. 273: 3954-62. PMID 9461582 DOI: 10.1074/Jbc.273.7.3954  0.72
1998 McPhee JC, Ragsdale DS, Scheuer T, Catterall WA. A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation. The Journal of Biological Chemistry. 273: 1121-9. PMID 9422778 DOI: 10.1074/Jbc.273.2.1121  0.686
1996 Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proceedings of the National Academy of Sciences of the United States of America. 93: 9270-5. PMID 8799190 DOI: 10.1073/Pnas.93.17.9270  0.647
1995 Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BF, Scheuer T, Catterall WA. Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 83: 433-42. PMID 8521473 DOI: 10.1016/0092-8674(95)90121-3  0.755
1995 Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA. Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. The Journal of Biological Chemistry. 270: 3306-12. PMID 7852416 DOI: 10.1074/Jbc.270.7.3306  0.756
1995 McPhee JC, Ragsdale DS, Scheuer T, Catterall WA. A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation. The Journal of Biological Chemistry. 270: 12025-34. PMID 7744852 DOI: 10.1074/Jbc.270.20.12025  0.65
1994 Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science (New York, N.Y.). 265: 1724-8. PMID 8085162 DOI: 10.1126/Science.8085162  0.671
1994 McPhee JC, Ragsdale DS, Scheuer T, Catterall WA. A mutation in segment IVS6 disrupts fast inactivation of sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 91: 12346-50. PMID 7991630 DOI: 10.1073/Pnas.91.25.12346  0.639
1993 Ragsdale DS, Numann R, Catterall WA, Scheuer T. Inhibition of Na+ channels by the novel blocker PD85,639. Molecular Pharmacology. 43: 949-54. PMID 8391119  0.555
1991 Ragsdale DS, Miledi R. Expressional potency of mRNAs encoding receptors and voltage-activated channels in the postmortem rat brain. Proceedings of the National Academy of Sciences of the United States of America. 88: 1854-8. PMID 1705710  0.334
1991 Ragsdale DS, Scheuer T, Catterall WA. Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs. Molecular Pharmacology. 40: 756-65. PMID 1658608  0.646
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