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Liangyi Chen, Ph.D - Publications

Affiliations: 
Institute of Molecule Medicine, Peking University, Beijing, Beijing Shi, China 
Area:
quantitative imaging of insulin secretion
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhang Y, Wang J, Xing S, Li L, Zhao S, Zhu W, Liang K, Liu Y, Chen L. Mitochondria determine the sequential propagation of the calcium macrodomains revealed by the super-resolution calcium lantern imaging. Science China. Life Sciences. PMID 32279282 DOI: 10.1007/S11427-019-1659-4  0.465
2020 Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, ... ... Chen L, et al. Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution. Nature Cell Biology. PMID 32123336 DOI: 10.1038/S41556-020-0475-2  0.333
2020 Dong D, Huang X, Li L, Mao H, Mo Y, Zhang G, Zhang Z, Shen J, Liu W, Wu Z, Liu G, Liu Y, Yang H, Gong Q, Shi K, ... Chen L, et al. Super-resolution fluorescence-assisted diffraction computational tomography reveals the three-dimensional landscape of the cellular organelle interactome. Light, Science & Applications. 9: 11. PMID 32025294 DOI: 10.1038/S41377-020-0249-4  0.336
2020 Pang H, Wang X, Zhao S, Xi W, Lv J, Qin J, Zhao Q, Che Y, Chen L, Li SJ. Loss of voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice. The Journal of Biological Chemistry. PMID 31949049 DOI: 10.1074/Jbc.Ra119.010489  0.319
2020 Yang Z, Li L, Ling J, Liu T, Huang X, Ying Y, Zhao Y, Zhao Y, Lei K, Chen L, Chen Z. Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging Chemical Science. 11: 8506-8516. DOI: 10.1039/D0Sc02837A  0.314
2019 Peng X, Huang X, Du K, Liu H, Chen L. High spatiotemporal resolution and low photo-toxicity fluorescence imaging in live cells and in vivo. Biochemical Society Transactions. PMID 31829403 DOI: 10.1042/Bst20190020  0.309
2019 Yao Q, Li L, Huang X, Li H, Fang Y, Xia J, Fan J, Chen L, Wang J, Peng X. A photo-stable fluorescent tracker for Imaging Mitochondria with Super Resolution. Analytical Chemistry. PMID 31718148 DOI: 10.1021/Acs.Analchem.9B04065  0.308
2019 Kang F, Zhou M, Huang X, Fan J, Wei L, Boulanger J, Liu Z, Salamero J, Liu Y, Chen L. E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca Store Replenishment. Scientific Reports. 9: 3975. PMID 30850711 DOI: 10.1038/S41598-019-40331-0  0.426
2019 Zhao J, Zong W, Zhao Y, Gou D, Liang S, Shen J, Wu Y, Zheng X, Wu R, Wang X, Niu F, Wang A, Zhang Y, Xiong JW, Chen L, et al. imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development. Elife. 8. PMID 30694176 DOI: 10.7554/Elife.41540  0.334
2018 Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, ... ... Chen L, et al. Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders. Nature Communications. 9: 2015. PMID 29789568 DOI: 10.1038/S41467-018-04352-Z  0.348
2018 Yuan L, Wang H, Liu Q, Wang Z, Zhang M, Zhao Y, Liang K, Chen L, Xu T, Xu P. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β cell survival. The Journal of Biological Chemistry. PMID 29769309 DOI: 10.1074/Jbc.Ra118.002399  0.348
2018 Huang X, Fan J, Li L, Liu H, Wu R, Wu Y, Wei L, Mao H, Lal A, Xi P, Tang L, Zhang Y, Liu Y, Tan S, Chen L. Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy. Nature Biotechnology. PMID 29644998 DOI: 10.1038/Nbt.4115  0.329
2018 Mo C, Chen S, Zhai M, Wu R, Wang Z, Yu J, Wang A, Chen L, Cheng H. In vivo optical imaging of brain activity Chinese Science Bulletin. 63: 3945-3960. DOI: 10.1360/N972018-01142  0.311
2017 Li P, Wei G, Cao Y, Deng Q, Han X, Huang X, Huo Y, He Y, Chen L, Luo J. Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor. Blood. PMID 29208598 DOI: 10.1182/Blood-2017-08-802140  0.302
2017 Liang K, Wei L, Chen L. Exocytosis, Endocytosis, and Their Coupling in Excitable Cells. Frontiers in Molecular Neuroscience. 10: 109. PMID 28469555 DOI: 10.3389/Fnmol.2017.00109  0.331
2016 Xie L, Dolai S, Kang Y, Liang T, Xie H, Qin T, Yang L, Chen L, Gaisano HY. Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells. Plos One. 11: e0147862. PMID 26848587 DOI: 10.1371/Journal.Pone.0147862  0.329
2016 Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Chen L, Zhang S, Huang Y, Dong M, Walker C, Hogan P, Wang Y, Zhou Y. Proteomic Mapping and Optogenetic Control of ER-PM Junctions in Living Cells Biophysical Journal. 110: 258a. DOI: 10.1016/J.Bpj.2015.11.1415  0.345
2015 Yuan T, Liu L, Zhang Y, Wei L, Zhao S, Zheng X, Huang X, Boulanger J, Gueudry C, Lu J, Xie L, Du W, Zong W, Yang L, Salamero J, ... ... Chen L, et al. Diacylglycerol Guides the Hopping of Clathrin-Coated Pits along Microtubules for Exo-Endocytosis Coupling. Developmental Cell. PMID 26439397 DOI: 10.1016/J.Devcel.2015.09.004  0.313
2015 Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, et al. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx. Nature Cell Biology. PMID 26322679 DOI: 10.1038/Ncb3234  0.414
2015 Zhou J, Tang Y, Zheng Q, Li M, Yuan T, Chen L, Huang Z, Wang K. Different KChIPs Compete for Heteromultimeric Assembly with Pore-Forming Kv4 Subunits. Biophysical Journal. 108: 2658-69. PMID 26039167 DOI: 10.1016/J.Bpj.2015.04.024  0.311
2015 Hao Z, Wei L, Feng Y, Chen X, Du W, Ma J, Zhou Z, Chen L, Li W. Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells. Journal of Cell Science. 128: 1365-74. PMID 25673877 DOI: 10.1242/Jcs.161414  0.335
2015 Yuan T, Lu J, Zhang J, Zhang Y, Chen L. Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells. Biophysical Journal. 108: 251-60. PMID 25606674 DOI: 10.1016/J.Bpj.2014.11.3462  0.37
2015 Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, ... ... Chen L, et al. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58: 324-33. PMID 25381556 DOI: 10.1007/S00125-014-3437-Z  0.401
2014 Liang K, Du W, Lu J, Li F, Yang L, Xue Y, Hille B, Chen L. Alterations of the Ca²⁺ signaling pathway in pancreatic beta-cells isolated from db/db mice. Protein & Cell. 5: 783-94. PMID 25053525 DOI: 10.1007/S13238-014-0075-7  0.612
2014 Zong W, Huang X, Zhang C, Yuan T, Zhu LL, Fan M, Chen L. Shadowless-illuminated variable-angle TIRF (siva-TIRF) microscopy for the observation of spatial-temporal dynamics in live cells. Biomedical Optics Express. 5: 1530-40. PMID 24877013 DOI: 10.1364/Boe.5.001530  0.31
2014 Shang W, Lu F, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ, Cheng H. Imaging Ca2+ nanosparks in heart with a new targeted biosensor. Circulation Research. 114: 412-20. PMID 24257462 DOI: 10.1161/Circresaha.114.302938  0.415
2014 Shang W, Lu F, Sun T, Xu J, Li L, Wang Y, Chen L, Wang X, Cannell MB, Wang S, Cheng H. Ca2+ Nanosparks: Junctional Ca2+ Dynamics Probed with a New Targeted Biosensor Biophysical Journal. 106: 319a-320a. DOI: 10.1016/J.Bpj.2013.11.1845  0.445
2013 Chen L, Xu T. On the stoichiometry of resting and activated CRAC channels. Current Topics in Membranes. 71: 95-108. PMID 23890112 DOI: 10.1016/B978-0-12-407870-3.00004-4  0.315
2013 Yang L, Ji W, Xue Y, Chen L. Imaging beta-cell mass and function in situ and in vivo. Journal of Molecular Medicine (Berlin, Germany). 91: 929-38. PMID 23700217 DOI: 10.1007/S00109-013-1056-7  0.334
2012 Dickson EJ, Duman JG, Moody MW, Chen L, Hille B. Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe. Proceedings of the National Academy of Sciences of the United States of America. 109: E3539-48. PMID 23184982 DOI: 10.1073/Pnas.1218247109  0.701
2012 Wen D, Xue Y, Liang K, Yuan T, Lu J, Zhao W, Xu T, Chen L. Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells. Protein & Cell. 3: 618-26. PMID 22729398 DOI: 10.1007/S13238-012-2938-0  0.377
2012 Koh DS, Cho JH, Chen L. Paracrine interactions within islets of Langerhans. Journal of Molecular Neuroscience : Mn. 48: 429-40. PMID 22528452 DOI: 10.1007/S12031-012-9752-2  0.315
2012 Liu L, Lu J, Liang K, Du W, Zhang Y, Li F, Yang L, Chen L. Microtubule-Driven Migration of Clathrin-Coated Pits Towards Vesicle Fusion Sites for Rapid Recycling in Pancreatic Beta Cells Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1760  0.349
2011 Liang K, Du W, Zhu W, Liu S, Cui Y, Sun H, Luo B, Xue Y, Yang L, Chen L, Li F. Contribution of different mechanisms to pancreatic beta-cell hyper-secretion in non-obese diabetic (NOD) mice during pre-diabetes. The Journal of Biological Chemistry. 286: 39537-45. PMID 21914804 DOI: 10.1074/Jbc.M111.295931  0.318
2011 Li Z, Liu L, Deng Y, Ji W, Du W, Xu P, Chen L, Xu T. Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits. Cell Research. 21: 305-15. PMID 20838418 DOI: 10.1038/Cr.2010.131  0.378
2010 Song X, Su W, Chen L, Ji JJ. Functional expression of large-conductance Ca2+-activated potassium channels in lateral globus pallidus neurons. Neuroscience. 169: 1548-56. PMID 20600663 DOI: 10.1016/J.Neuroscience.2010.06.026  0.35
2010 Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W, Liu Y. Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3720-32. PMID 20501795 DOI: 10.1096/Fj.09-152363  0.354
2010 Cho JH, Chen L, Kim MH, Chow RH, Hille B, Koh DS. Characteristics and functions of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors expressed in mouse pancreatic {alpha}-cells. Endocrinology. 151: 1541-50. PMID 20189997 DOI: 10.1210/En.2009-0362  0.605
2010 Du W, Liu L, Liang K, Lu J, Li F, Xu T, Chen L. Dephosphorylation of Dynamin1 is a Ca2+ Sensor that Triggers Clathrin- Independent Vesicle Recycling Processes in Pancreatic Beta Cells Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2726  0.467
2009 Gao S, Fan Y, Chen L, Lu J, Xu T, Xu P. Mechanism of different spatial distributions of Caenorhabditis elegans and human STIM1 at resting state. Cell Calcium. 45: 77-88. PMID 18667236 DOI: 10.1016/J.Ceca.2008.06.005  0.326
2009 Ji W, Xu P, Li Z, Lu J, Liu L, Zhan Y, Chen Y, Hille B, Xu T, Chen L. Functional Stoichiometry Of The Unitary Calcium-release-activated Calcium Channel Revealed By Single-molecule Imaging Biophysical Journal. 96: 560a. DOI: 10.1016/J.Bpj.2008.12.3675  0.587
2008 Ji W, Xu P, Li Z, Lu J, Liu L, Zhan Y, Chen Y, Hille B, Xu T, Chen L. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proceedings of the National Academy of Sciences of the United States of America. 105: 13668-73. PMID 18757751 DOI: 10.1073/Pnas.0806499105  0.587
2008 Lu J, He Z, Fan J, Xu P, Chen L. Overlapping functions of different dynamin isoforms in clathrin-dependent and -independent endocytosis in pancreatic beta cells. Biochemical and Biophysical Research Communications. 371: 315-9. PMID 18442475 DOI: 10.1016/J.Bbrc.2008.04.077  0.387
2008 Duman JG, Chen L, Hille B. Calcium transport mechanisms of PC12 cells. The Journal of General Physiology. 131: 307-23. PMID 18347082 DOI: 10.1083/Jcb1812Oia9  0.693
2008 He Z, Fan J, Kang L, Lu J, Xue Y, Xu P, Xu T, Chen L. Ca2+ triggers a novel clathrin-independent but actin-dependent fast endocytosis in pancreatic beta cells. Traffic (Copenhagen, Denmark). 9: 910-23. PMID 18315531 DOI: 10.1111/J.1600-0854.2008.00730.X  0.474
2008 Jiang L, Fan J, Bai L, Wang Y, Chen Y, Yang L, Chen L, Xu T. Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles. The Journal of Biological Chemistry. 283: 8508-16. PMID 18063571 DOI: 10.1074/Jbc.M708688200  0.309
2007 Li Z, Lu J, Xu P, Xie X, Chen L, Xu T. Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. The Journal of Biological Chemistry. 282: 29448-56. PMID 17702753 DOI: 10.1074/Jbc.M703573200  0.419
2006 Xu P, Lu J, Li Z, Yu X, Chen L, Xu T. Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1. Biochemical and Biophysical Research Communications. 350: 969-76. PMID 17045966 DOI: 10.1016/J.Bbrc.2006.09.134  0.327
2006 Duman JG, Chen L, Palmer AE, Hille B. Contributions of intracellular compartments to calcium dynamics: implicating an acidic store. Traffic (Copenhagen, Denmark). 7: 859-72. PMID 16787398 DOI: 10.1111/J.1600-0854.2006.00432.X  0.704
2006 Xie L, Zhang M, Zhou W, Wu Z, Ding J, Chen L, Xu T. Extracellular ATP stimulates exocytosis via localized Ca(2+) release from acidic stores in rat pancreatic beta cells. Traffic (Copenhagen, Denmark). 7: 429-39. PMID 16536741 DOI: 10.1111/J.1600-0854.2006.00401.X  0.453
2003 Chen L, Koh DS, Hille B. Dynamics of calcium clearance in mouse pancreatic beta-cells. Diabetes. 52: 1723-31. PMID 12829639 DOI: 10.2337/Diabetes.52.7.1723  0.622
2000 Chen L, Zou S, Lou X, Kang HG. Different stimulatory opioid effects on intracellular Ca(2+) in SH-SY5Y cells. Brain Research. 882: 256-65. PMID 11056210 DOI: 10.1016/S0006-8993(00)02904-8  0.417
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