Derrick F. MacFabe, MD - Publications

Psychology University of Western Ontario, London, Ontario, Canada 
animal models-autism

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mepham JR, MacFabe DF, Boon FH, Foley KA, Cain DP, Ossenkopp KP. Examining the non-spatial pretraining effect on a Water Maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD. Behavioural Brain Research. 113140. PMID 33508348 DOI: 10.1016/j.bbr.2021.113140  0.96
2019 Meeking MM, MacFabe DF, Mepham JR, Foley KA, Tichenoff LJ, Boon FH, Kavaliers M, Ossenkopp KP. Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109794. PMID 31639413 DOI: 10.1016/j.pnpbp.2019.109794  0.96
2019 Mepham JR, Boon FH, Foley KA, Cain DP, MacFabe DF, Ossenkopp KP. Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD. Neurotoxicity Research. PMID 30848474 DOI: 10.1007/s12640-019-0002-z  0.96
2019 Shams S, Foley KA, Kavaliers M, MacFabe DF, Ossenkopp KP. Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder. Developmental Psychobiology. PMID 30689218 DOI: 10.1002/dev.21825  0.96
2015 Shultz SR, Aziz NA, Yang L, Sun M, MacFabe DF, O'Brien TJ. Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats. Behavioural Brain Research. 278: 542-8. PMID 25446754 DOI: 10.1016/j.bbr.2014.10.050  0.48
2015 Foley KA, MacFabe DF, Kavaliers M, Ossenkopp KP. Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders. Behavioural Brain Research. 278: 244-56. PMID 25300465 DOI: 10.1016/j.bbr.2014.09.032  0.96
2014 Nankova BB, Agarwal R, MacFabe DF, La Gamma EF. Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells--possible relevance to autism spectrum disorders. Plos One. 9: e103740. PMID 25170769 DOI: 10.1371/journal.pone.0103740  0.48
2014 Foley KA, MacFabe DF, Vaz A, Ossenkopp KP, Kavaliers M. Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 39: 68-78. PMID 24747144 DOI: 10.1016/j.ijdevneu.2014.04.001  0.96
2014 Foley KA, Ossenkopp KP, Kavaliers M, Macfabe DF. Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. Plos One. 9: e87072. PMID 24466331 DOI: 10.1371/journal.pone.0087072  0.96
2013 Frye RE, Melnyk S, Macfabe DF. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry. 3: e220. PMID 23340503 DOI: 10.1038/tp.2012.143  0.48
2012 Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S, MacFabe DF. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. Journal of Neuroinflammation. 9: 153. PMID 22747852 DOI: 10.1186/1742-2094-9-153  0.48
2012 Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments. Behavioural Brain Research. 229: 145-52. PMID 22245525 DOI: 10.1016/j.bbr.2011.12.015  0.48
2012 Ossenkopp KP, Foley KA, Gibson J, Fudge MA, Kavaliers M, Cain DP, Macfabe DF. Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. Behavioural Brain Research. 227: 134-41. PMID 22085877 DOI: 10.1016/j.bbr.2011.10.045  0.96
2011 Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: support for an animal model of concussion. Behavioural Brain Research. 224: 326-35. PMID 21704658 DOI: 10.1016/j.bbr.2011.06.012  0.48
2011 Nie HY, Taylor AR, Lau WM, MacFabe DF. Subcellular features revealed on unfixed rat brain sections by phase imaging. The Analyst. 136: 2270-6. PMID 21509366 DOI: 10.1039/c1an15125h  0.48
2011 MacFabe DF, Cain NE, Boon F, Ossenkopp KP, Cain DP. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. Behavioural Brain Research. 217: 47-54. PMID 20937326 DOI: 10.1016/j.bbr.2010.10.005  0.96
2011 Nie HY, Taylor AR, Francis JT, Walzak MJ, Lau WM, MacFabe DF. Tracing propionic acid infused to rat brain via deuterium tagging-further development of a novel rodent model of autism spectrum disorders Surface and Interface Analysis. 43: 358-362. DOI: 10.1002/sia.3536  0.48
2010 Thomas RH, Foley KA, Mepham JR, Tichenoff LJ, Possmayer F, MacFabe DF. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders. Journal of Neurochemistry. 113: 515-29. PMID 20405543 DOI: 10.1111/j.1471-4159.2010.06614.x  0.48
2009 Shultz SR, Macfabe DF, Martin S, Jackson J, Taylor R, Boon F, Ossenkopp KP, Cain DP. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behavioural Brain Research. 200: 33-41. PMID 19154758 DOI: 10.1016/j.bbr.2008.12.023  0.96
2008 Shultz SR, MacFabe DF, Ossenkopp KP, Scratch S, Whelan J, Taylor R, Cain DP. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology. 54: 901-11. PMID 18395759 DOI: 10.1016/j.neuropharm.2008.01.013  0.96
2008 Francis JT, Nie HY, Taylor AR, Walzak MJ, Chang WH, MacFabe DF, Lau WM. ToF-SIMS cluster ion imaging of hippocampal CA1 pyramidal rat neurons Applied Surface Science. 255: 1126-1130. DOI: 10.1016/j.apsusc.2008.05.258  0.48
2008 Nie HY, Francis JT, Taylor AR, Walzak MJ, Chang WH, MacFabe DF, Lau WM. Imaging subcellular features of a sectioned rat brain using time-of-flight secondary ion mass spectrometry and scanning probe microscopy Applied Surface Science. 255: 1079-1083. DOI: 10.1016/j.apsusc.2008.05.149  0.48
2008 MacFabe DF, Rodríguez-Capote K, Hoffman JE, Franklin AE, Mohammad-Asef Y, Taylor AR, Boon F, Cain DP, Kavaliers M, Possmayer F, Ossenkopp KP. A novel rodent model of autism: Intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain American Journal of Biochemistry and Biotechnology. 4: 146-166.  0.48
2007 MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F, Taylor AR, Kavaliers M, Ossenkopp KP. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behavioural Brain Research. 176: 149-69. PMID 16950524 DOI: 10.1016/j.bbr.2006.07.025  0.96
2007 Conklin CMJ, Bechberger JF, MacFabe D, Guthrie N, Kurowska EM, Naus CC. Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells Carcinogenesis. 28: 93-100. PMID 16777995 DOI: 10.1093/carcin/bgl106  0.48
2002 Frantseva MV, Kokarovtseva L, Naus CG, Carlen PL, MacFabe D, Perez Velazquez JL. Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury Journal of Neuroscience. 22: 644-653. PMID 11826094  0.48
1987 Borst JG, Leung LW, MacFabe DF. Electrical activity of the cingulate cortex. II. Cholinergic modulation. Brain Research. 407: 81-93. PMID 3580858 DOI: 10.1016/0006-8993(87)91221-2  0.48
1985 Stewart DJ, MacFabe DF, Leung LW. Topographical projection of cholinergic neurons in the basal forebrain to the cingulate cortex in the rat. Brain Research. 358: 404-7. PMID 4075131 DOI: 10.1016/0006-8993(85)90994-1  0.48
1984 Stewart DJ, MacFabe DF, Vanderwolf CH. Cholinergic activation of the electrocorticogram: role of the substantia innominata and effects of atropine and quinuclidinyl benzilate. Brain Research. 322: 219-32. PMID 6509315 DOI: 10.1016/0006-8993(84)90112-4  0.48
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