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Derrick F. MacFabe, MD - Publications

Affiliations: 
Psychology University of Western Ontario, London, Ontario, Canada 
Area:
animal models-autism
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mepham JR, MacFabe DF, Boon FH, Foley KA, Cain DP, Ossenkopp KP. Examining the non-spatial pretraining effect on a Water Maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD. Behavioural Brain Research. 113140. PMID 33508348 DOI: 10.1016/j.bbr.2021.113140  0.771
2020 Lobzhanidze G, Japaridze N, Lordkipanidze T, Rzayev F, MacFabe D, Zhvania M. Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 31997401 DOI: 10.1002/jdn.10011  0.455
2019 Meeking MM, MacFabe DF, Mepham JR, Foley KA, Tichenoff LJ, Boon FH, Kavaliers M, Ossenkopp KP. Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109794. PMID 31639413 DOI: 10.1016/J.Pnpbp.2019.109794  0.772
2019 Mepham JR, Boon FH, Foley KA, Cain DP, MacFabe DF, Ossenkopp KP. Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD. Neurotoxicity Research. PMID 30848474 DOI: 10.1007/S12640-019-0002-Z  0.794
2019 Shams S, Foley KA, Kavaliers M, MacFabe DF, Ossenkopp KP. Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder. Developmental Psychobiology. PMID 30689218 DOI: 10.1002/Dev.21825  0.808
2016 Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. Translational Psychiatry. 6: e927. PMID 27779624 DOI: 10.1038/Tp.2016.189  0.381
2016 Slattery J, MacFabe DF, Kahler SG, Frye RE. Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? Current Pharmaceutical Design. PMID 27592717 DOI: 10.2174/1381612822666160905123953  0.357
2015 MacFabe DF. Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microbial Ecology in Health and Disease. 26: 28177. PMID 26031685 DOI: 10.3402/Mehd.V26.28177  0.396
2015 Frye RE, Rose S, Slattery J, MacFabe DF. Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial Ecology in Health and Disease. 26: 27458. PMID 25956238 DOI: 10.3402/Mehd.V26.27458  0.392
2015 Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown R, Bolte E, Kahler S, Jennings J, James J, Cerniglia CE, Midtvedt T. Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microbial Ecology in Health and Disease. 26: 26878. PMID 25956237 DOI: 10.3402/Mehd.V26.26878  0.343
2015 Shultz SR, Aziz NA, Yang L, Sun M, MacFabe DF, O'Brien TJ. Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats. Behavioural Brain Research. 278: 542-8. PMID 25446754 DOI: 10.1016/J.Bbr.2014.10.050  0.568
2015 Foley KA, MacFabe DF, Kavaliers M, Ossenkopp KP. Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders. Behavioural Brain Research. 278: 244-56. PMID 25300465 DOI: 10.1016/J.Bbr.2014.09.032  0.766
2014 Nankova BB, Agarwal R, MacFabe DF, La Gamma EF. Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells--possible relevance to autism spectrum disorders. Plos One. 9: e103740. PMID 25170769 DOI: 10.1371/Journal.Pone.0103740  0.438
2014 Foley KA, MacFabe DF, Vaz A, Ossenkopp KP, Kavaliers M. Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 39: 68-78. PMID 24747144 DOI: 10.1016/J.Ijdevneu.2014.04.001  0.791
2014 Foley KA, Ossenkopp KP, Kavaliers M, Macfabe DF. Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. Plos One. 9: e87072. PMID 24466331 DOI: 10.1371/Journal.Pone.0087072  0.788
2014 Macfabe D. Autism: metabolism, mitochondria, and the microbiome. Global Advances in Health and Medicine. 2: 52-66. PMID 24416709 DOI: 10.7453/gahmj.2013.089  0.395
2013 Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Slattery JC, Lau C, Hardy P, Fatemi SH, Folsom TD, Macfabe D, Adams JB. A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel. Frontiers in Public Health. 1: 31. PMID 24350200 DOI: 10.3389/Fpubh.2013.00031  0.343
2013 Frye RE, Melnyk S, Macfabe DF. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry. 3: e220. PMID 23340503 DOI: 10.1038/Tp.2012.143  0.438
2012 Macfabe DF. Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial Ecology in Health and Disease. 23. PMID 23990817 DOI: 10.3402/Mehd.V23I0.19260  0.625
2012 Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S, MacFabe DF. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. Journal of Neuroinflammation. 9: 153. PMID 22747852 DOI: 10.1186/1742-2094-9-153  0.519
2012 Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments. Behavioural Brain Research. 229: 145-52. PMID 22245525 DOI: 10.1016/J.Bbr.2011.12.015  0.65
2012 Ossenkopp KP, Foley KA, Gibson J, Fudge MA, Kavaliers M, Cain DP, Macfabe DF. Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. Behavioural Brain Research. 227: 134-41. PMID 22085877 DOI: 10.1016/J.Bbr.2011.10.045  0.767
2011 Shultz SR, MacFabe DF, Foley KA, Taylor R, Cain DP. A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: support for an animal model of concussion. Behavioural Brain Research. 224: 326-35. PMID 21704658 DOI: 10.1016/J.Bbr.2011.06.012  0.681
2011 MacFabe DF, Cain NE, Boon F, Ossenkopp KP, Cain DP. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. Behavioural Brain Research. 217: 47-54. PMID 20937326 DOI: 10.1016/J.Bbr.2010.10.005  0.815
2011 Nie HY, Taylor AR, Francis JT, Walzak MJ, Lau WM, MacFabe DF. Tracing propionic acid infused to rat brain via deuterium tagging-further development of a novel rodent model of autism spectrum disorders Surface and Interface Analysis. 43: 358-362. DOI: 10.1002/sia.3536  0.442
2010 Thomas RH, Foley KA, Mepham JR, Tichenoff LJ, Possmayer F, MacFabe DF. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders. Journal of Neurochemistry. 113: 515-29. PMID 20405543 DOI: 10.1111/J.1471-4159.2010.06614.X  0.508
2009 Shultz SR, Macfabe DF, Martin S, Jackson J, Taylor R, Boon F, Ossenkopp KP, Cain DP. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behavioural Brain Research. 200: 33-41. PMID 19154758 DOI: 10.1016/J.Bbr.2008.12.023  0.802
2008 Shultz SR, MacFabe DF, Ossenkopp KP, Scratch S, Whelan J, Taylor R, Cain DP. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology. 54: 901-11. PMID 18395759 DOI: 10.1016/J.Neuropharm.2008.01.013  0.819
2008 MacFabe DF, Rodríguez-Capote K, Hoffman JE, Franklin AE, Mohammad-Asef Y, Taylor AR, Boon F, Cain DP, Kavaliers M, Possmayer F, Ossenkopp KP. A novel rodent model of autism: Intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain American Journal of Biochemistry and Biotechnology. 4: 146-166. DOI: 10.3844/Ajbbsp.2008.146.166  0.757
2007 MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F, Taylor AR, Kavaliers M, Ossenkopp KP. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behavioural Brain Research. 176: 149-69. PMID 16950524 DOI: 10.1016/J.Bbr.2006.07.025  0.799
1987 Borst JG, Leung LW, MacFabe DF. Electrical activity of the cingulate cortex. II. Cholinergic modulation. Brain Research. 407: 81-93. PMID 3580858 DOI: 10.1016/0006-8993(87)91221-2  0.327
1984 Stewart DJ, MacFabe DF, Vanderwolf CH. Cholinergic activation of the electrocorticogram: role of the substantia innominata and effects of atropine and quinuclidinyl benzilate. Brain Research. 322: 219-32. PMID 6509315 DOI: 10.1016/0006-8993(84)90112-4  0.379
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