| Year |
Citation |
Score |
| 2017 |
Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716944 DOI: 10.1073/Pnas.1620220114 |
0.392 |
|
| 2016 |
Im MM, Flanagan SA, Ackroyd JJ, Knapp B, Kramer A, Shewach DS. Late DNA Damage Mediated by Homologous Recombination Repair Results in Radiosensitization with Gemcitabine. Radiation Research. PMID 27740890 DOI: 10.1667/Rr14443.1 |
0.357 |
|
| 2016 |
Flanagan SA, Ackroyd JJ, Kramer A, Feigin J, Shewach DS. Abstract 2999: Cytotoxicity with hydroxamic acid HDACis in combination with antimetabolites is highly sequence dependent in solid tumor cells Cancer Research. 76: 2999-2999. DOI: 10.1158/1538-7445.Am2016-2999 |
0.447 |
|
| 2015 |
Im MM, Flanagan SA, Ackroyd JJ, Shewach DS. Drug metabolism and homologous recombination repair in radiosensitization with gemcitabine. Radiation Research. 183: 114-23. PMID 25564718 DOI: 10.1667/Rr13807.1 |
0.492 |
|
| 2015 |
Flanagan SA, Ackroyd J, Shewach DS. Abstract 2553: Gemcitabine fails to radiosensitize normal intestinal epithelial CCD841 cells at concentrations that promote excellent radiosensitization in colorectal tumor cell lines Cancer Research. 75: 2553-2553. DOI: 10.1158/1538-7445.Am2015-2553 |
0.399 |
|
| 2014 |
Flanagan SA, Ackroyd JJ, Mannava S, Nikiforov MA, Shewach DS. Abstract 847: Suppression of p53R2 but not R2 radiosensitizes mutant p53 tumor cells Cancer Research. 74: 847-847. DOI: 10.1158/1538-7445.Am2014-847 |
0.376 |
|
| 2013 |
Ladd B, Ackroyd JJ, Hicks JK, Canman CE, Flanagan SA, Shewach DS. Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity. Dna Repair. 12: 1114-21. PMID 24231389 DOI: 10.1016/J.Dnarep.2013.10.008 |
0.457 |
|
| 2013 |
Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. The American Journal of Pathology. 182: 142-51. PMID 23245831 DOI: 10.1016/J.Ajpath.2012.09.011 |
0.395 |
|
| 2013 |
Flanagan SA, Cooper K, Mannava S, Nikiforov M, Shewach DS. Abstract 445: shRNA mediated suppression of either of the small subunits of ribonucleotide reductase, R2 and p53R2, elicits a robust increase in sensitivity to ionizing radiation. Cancer Research. 73: 445-445. DOI: 10.1158/1538-7445.Am2013-445 |
0.362 |
|
| 2012 |
Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianchi-Smiraglia A, Berman AE, Flanagan S, Shewach DS, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA. Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion. Aging. 4: 917-22. PMID 23249808 |
0.384 |
|
| 2012 |
Flanagan SA, Cooper KS, Mannava S, Nikiforov MA, Shewach DS. Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization. International Journal of Radiation Oncology, Biology, Physics. 84: e613-20. PMID 22867891 DOI: 10.1016/J.Ijrobp.2012.06.050 |
0.302 |
|
| 2010 |
O'Konek JJ, Ladd B, Flanagan SA, Im MM, Boucher PD, Thepsourinthone TS, Secrist JA, Shewach DS. Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity. Mutation Research. 684: 1-10. PMID 20004674 DOI: 10.1016/J.Mrfmmm.2009.11.011 |
0.453 |
|
| 2010 |
Flanagan SA, Nikiforov MA, Mannava S, Shewach DS. Abstract 1390: shRNA mediated suppression of thymidylate synthase results in an increased sensitivity to ionizing radiation similar to 5-fluoro-2′-deoxyuridine Cancer Research. 70: 1390-1390. DOI: 10.1158/1538-7445.Am10-1390 |
0.407 |
|
| 2010 |
Im MM, Flanagan SA, Ladd BP, Shewach DS. Abstract 1316: Late-occurring DNA damage is responsible for radiosensitization with gemcitabine Cancer Research. 70: 1316-1316. DOI: 10.1158/1538-7445.Am10-1316 |
0.392 |
|
| 2008 |
Flanagan SA, Krokosky CM, Mannava S, Nikiforov MA, Shewach DS. MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches. Molecular Pharmacology. 74: 863-71. PMID 18535288 DOI: 10.1124/Mol.107.043349 |
0.459 |
|
| 2007 |
Flanagan SA, Gandhi V, Meckling KA. Guanosine acts intracellularly to initiate apoptosis in NB4 cells: A role for nucleoside transport. Leukemia & Lymphoma. 48: 1816-27. PMID 17786719 DOI: 10.1080/10428190701528491 |
0.659 |
|
| 2007 |
Flanagan SA, Robinson BW, Krokosky CM, Shewach DS. Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers. Molecular Cancer Therapeutics. 6: 1858-68. PMID 17575114 DOI: 10.1158/1535-7163.Mct-07-0068 |
0.433 |
|
| 2007 |
Flanagan SA, Meckling KA. Nucleoside transporter expression and activity is regulated during granulocytic differentiation of NB4 cells in response to all-trans-retinoic acid. Leukemia Research. 31: 955-68. PMID 17045336 DOI: 10.1016/J.Leukres.2006.09.010 |
0.668 |
|
| 2003 |
Flanagan SA, Gandhi V, Secrist JA, Meckling KA. The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-G. Biochemical Pharmacology. 66: 733-7. PMID 12948853 DOI: 10.1016/S0006-2952(03)00393-9 |
0.648 |
|
| 2003 |
Flanagan SA, Meckling KA. All- trans-retinoic acid increases cytotoxicity of 1-beta-D-arabinofuranosylcytosine in NB4 cells. Cancer Chemotherapy and Pharmacology. 51: 363-75. PMID 12736759 DOI: 10.1007/s00280-002-0561-0 |
0.658 |
|
| 1997 |
Flanagan SA, Meckling-Gill KA. Characterization of a novel Na+-dependent, guanosine-specific, nitrobenzylthioinosine-sensitive transporter in acute promyelocytic leukemia cells Journal of Biological Chemistry. 272: 18026-18032. PMID 9218431 DOI: 10.1074/Jbc.272.29.18026 |
0.538 |
|
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