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K Wimalasena - Publications

Affiliations: 
Wichita State University, Wichita, KS, United States 
Area:
Biochemistry
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lickteig B, Wimalasena VK, Wimalasena K. MPP+ Scaffold Containing Lipophilic Compounds are Potent Complex I Inhibitors and Selective Dopaminergic Toxins. Acs Chemical Neuroscience. PMID 30929447 DOI: 10.1021/Acschemneuro.9B00184  0.435
2018 Mapa MST, Le VQ, Wimalasena K. Characteristics of the mitochondrial and cellular uptake of MPP+, as probed by the fluorescent mimic, 4'I-MPP. Plos One. 13: e0197946. PMID 30138351 DOI: 10.1371/Journal.Pone.0197946  0.376
2017 Wimalasena K. Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+ Advances in Molecular Toxicology. 11: 81-122. DOI: 10.1016/B978-0-12-812522-9.00003-8  0.352
2016 Kadigamuwa CC, Mapa MS, Wimalasena K. Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP(.) Chemical Research in Toxicology. PMID 27510327 DOI: 10.1021/Acs.Chemrestox.6B00138  0.442
2016 Wimalasena NK, Le VQ, Wimalasena K, Schreiber SL, Karmacharya R. Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. Acs Chemical Neuroscience. PMID 27270122 DOI: 10.1021/Acschemneuro.6B00076  0.322
2016 Wimalasena K. The inherent high vulnerability of dopaminergic neurons toward mitochondrial toxins may contribute to the etiology of Parkinson's disease. Neural Regeneration Research. 11: 246-7. PMID 27073376 DOI: 10.4103/1673-5374.177730  0.411
2016 Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, ... ... Wimalasena K, et al. Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain. Nature Communications. 7: 10652. PMID 26879809 DOI: 10.1038/Ncomms10652  0.385
2015 Kadigamuwa CC, Le VQ, Wimalasena K. 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP⁺. Journal of Neurochemistry. 135: 755-67. PMID 26094622 DOI: 10.1111/Jnc.13201  0.428
2008 Wimalasena DS, Perera RP, Heyen BJ, Balasooriya IS, Wimalasena K. Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. Journal of Medicinal Chemistry. 51: 760-8. PMID 18220329 DOI: 10.1021/Jm070875P  0.724
2008 Bhakta MN, Olabisi A, Wimalasena K, Wilks A. Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid. Journal of Inorganic Biochemistry. 102: 251-9. PMID 17923157 DOI: 10.1016/J.Jinorgbio.2007.08.007  0.36
2007 Samms WC, Perera RP, Wimalasena DS, Wimalasena K. Perturbation of dopamine metabolism by 3-amino-2-(4'-halophenyl)propenes leads to increased oxidative stress and apoptotic SH-SY5Y cell death. Molecular Pharmacology. 72: 744-52. PMID 17576792 DOI: 10.1124/Mol.107.035873  0.724
2007 Wimalasena DS, Wiese TJ, Wimalasena K. Copper ions disrupt dopamine metabolism via inhibition of V-H+-ATPase: a possible contributing factor to neurotoxicity. Journal of Neurochemistry. 101: 313-26. PMID 17217412 DOI: 10.1111/J.1471-4159.2006.04362.X  0.38
2005 Bhakta MN, Hollenberg PF, Wimalasena K. P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct. Journal of the American Chemical Society. 127: 1376-7. PMID 15686361 DOI: 10.1021/Ja0436143  0.311
2005 Bhakta MN, Wimalasena K. A Mechanistic Comparison between Cytochrome P450- and Chloroperoxidase-CatalyzedN-Dealkylation ofN,N-Dialkyl Anilines European Journal of Organic Chemistry. 2005: 4801-4805. DOI: 10.1002/Ejoc.200500333  0.311
2004 Olabisi AO, Wimalasena K. Rational approach to selective and direct 2-O-alkylation of 5,6-O-isopropylidine-L-ascorbic acid. The Journal of Organic Chemistry. 69: 7026-32. PMID 15471448 DOI: 10.1002/CHIN.200507213  0.356
2004 Wimalasena DS, Wimalasena K. Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts. The Journal of Biological Chemistry. 279: 15298-304. PMID 14732710 DOI: 10.1074/Jbc.M313325200  0.389
2003 Perera RP, Wimalasena DS, Wimalasena K. Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors. Journal of Medicinal Chemistry. 46: 2599-605. PMID 12801224 DOI: 10.1021/Jm030004P  0.712
2003 Wanduragala S, Wimalasena DS, Haines DC, Kahol PK, Wimalasena K. pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b(561): implications for the oxidative stress in catecholaminergic neurons. Biochemistry. 42: 3617-26. PMID 12653566 DOI: 10.1021/Bi0206661  0.613
2002 Dharmasena SP, Wimalasena DS, Wimalasena K. A slow-tight binding inhibitor of dopamine beta-monooxygenase: a transition state analogue for the product release step. Biochemistry. 41: 12414-20. PMID 12369831 DOI: 10.1021/Bi0262606  0.376
2002 Wimalasena DS, Jayatillake SP, Haines DC, Wimalasena K. Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction. The Biochemical Journal. 367: 77-85. PMID 12038965 DOI: 10.1042/Bj20020216  0.43
2001 Wimalasena K, Wickman H, Mahindaratne M. Autocatalytic Radical Ring Opening ofN-Cyclopropyl-N-phenylamines Under Aerobic Conditions − Exclusive Formation of the Unknown Oxygen Adducts,N-(1,2-Dioxolan-3-yl)-N-phenylamines European Journal of Organic Chemistry. 2001: 3811-3817. DOI: 10.1002/1099-0690(200110)2001:20<3811::Aid-Ejoc3811>3.0.Co;2-6  0.325
1999 Wimalasena K, Alliston KR. Mode of substrate interaction and energetics of carbon-oxygen bond formation of the dopamine beta-monooxygenase reaction. Biochemistry. 38: 14916-26. PMID 10555974 DOI: 10.1021/Bi990703X  0.345
1996 Wimalasena K, Dharmasena S, Wimalasena DS, Hughbanks-Wheaton DK. Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation. The Journal of Biological Chemistry. 271: 26032-43. PMID 8824243 DOI: 10.1074/Jbc.271.42.26032  0.397
1996 Wimalasena K, Haines DC. A general progress curve method for the kinetic analysis of suicide enzyme inhibitors. Analytical Biochemistry. 234: 175-82. PMID 8714595 DOI: 10.1006/Abio.1996.0069  0.324
1995 Wimalasena K, Wimalasena DS. The reduction of membrane-bound dopamine beta-monooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extragranular reducing equivalents? The Journal of Biological Chemistry. 270: 27516-24. PMID 7499210 DOI: 10.1074/Jbc.270.46.27516  0.352
1995 Wimalasena K, Alliston KR. 1-(2-Aminoethyl)-1,4-cyclohexadiene: A Probe To Examine the Chemistry and Energetics Of The C-H Bond Cleavage in Dopamine .beta.-Monooxygenase Catalysis Journal of the American Chemical Society. 117: 1220-1224. DOI: 10.1021/Ja00109A005  0.316
1994 Wimalasena K, Dharmasena S, Wimalasena DS. Ascorbate based novel high affinity alternate reductants and competitive inhibitors of dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 200: 113-9. PMID 8166679 DOI: 10.1006/Bbrc.1994.1422  0.383
1994 Wimalasena K, Dharmasena S. Substrate specificity of ascorbate oxidase: unexpected similarity to the reduction site of dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 203: 1471-6. PMID 7945293 DOI: 10.1006/Bbrc.1994.2350  0.383
1993 Wimalasena K, Dharmasena S. Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid. Analytical Biochemistry. 210: 58-62. PMID 8489025 DOI: 10.1006/Abio.1993.1150  0.378
1991 Wimalasena K, Wimalasena DS. N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 175: 920-7. PMID 2025264 DOI: 10.1016/0006-291X(91)91653-T  0.417
1991 Wimalasena K, Wimalasena DS. Continuous spectrophotometric assays for dopamine beta-monooxygenase based on two novel electron donors: N,N-dimethyl-1,4-phenylenediamine and 2-aminoascorbic acid. Analytical Biochemistry. 197: 353-61. PMID 1785690 DOI: 10.1016/0003-2697(91)90404-H  0.418
1989 Wimalasena K, Herman HH, May SW. Effects of dopamine beta-monooxygenase substrate analogs on ascorbate levels and norepinephrine synthesis in adrenal chromaffin granule ghosts. The Journal of Biological Chemistry. 264: 124-30. PMID 2909510  0.338
1989 Wimalasena K, May SW. Dopamine .beta.-monooxygenase-catalyzed aromatization of 1-(2-aminoethyl)-1,4-cyclohexadiene: redirection of specificity and evidence for a hydrogen-atom-transfer mechanism Journal of the American Chemical Society. 111: 2729-2731. DOI: 10.1021/Ja00189A065  0.324
1987 Wimalasena K, May SW. Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism Journal of the American Chemical Society. 109: 4036-4046. DOI: 10.1021/Ja00247A033  0.377
1985 Padgette SR, Wimalasena K, Herman HH, Sirimanne SR, May SW. Olefin oxygenation and N-dealkylation by dopamine beta-monooxygenase: catalysis and mechanism-based inhibition. Biochemistry. 24: 5826-39. PMID 4084493 DOI: 10.1021/Bi00342A021  0.432
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