James G. Smedley, Ph.D. - Publications

Affiliations: 
2007 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Microbiology Biology, Biochemistry

12 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Chen J, Theoret JR, Shrestha A, Smedley JG, McClane BA. Cysteine-scanning mutagenesis supports the importance of Clostridium perfringens enterotoxin amino acids 80 to 106 for membrane insertion and pore formation. Infection and Immunity. 80: 4078-88. PMID 22966051 DOI: 10.1128/Iai.00069-12  0.574
2011 Briggs DC, Naylor CE, Smedley JG, Lukoyanova N, Robertson S, Moss DS, McClane BA, Basak AK. Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. Journal of Molecular Biology. 413: 138-49. PMID 21839091 DOI: 10.1016/J.Jmb.2011.07.066  0.621
2010 Briggs DC, Smedley JG, McClane BA, Basak AK. Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 794-7. PMID 20606275 DOI: 10.1107/S1744309110016507  0.527
2010 Robertson SL, Smedley JG, McClane BA. Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin. Infection and Immunity. 78: 505-17. PMID 19884339 DOI: 10.1128/Iai.00778-09  0.595
2008 Smedley JG, Saputo J, Parker JC, Fernandez-Miyakawa ME, Robertson SL, McClane BA, Uzal FA. Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity. Infection and Immunity. 76: 3793-800. PMID 18505809 DOI: 10.1128/Iai.00460-08  0.573
2008 Van Itallie CM, Betts L, Smedley JG, McClane BA, Anderson JM. Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. The Journal of Biological Chemistry. 283: 268-74. PMID 17977833 DOI: 10.1074/Jbc.M708066200  0.599
2007 Kominsky SL, Tyler B, Sosnowski J, Brady K, Doucet M, Nell D, Smedley JG, McClane B, Brem H, Sukumar S. Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Research. 67: 7977-82. PMID 17804705 DOI: 10.1158/0008-5472.Can-07-1314  0.501
2007 Robertson SL, Smedley JG, Singh U, Chakrabarti G, Van Itallie CM, Anderson JM, McClane BA. Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cellular Microbiology. 9: 2734-55. PMID 17587331 DOI: 10.1111/J.1462-5822.2007.00994.X  0.585
2007 Litkouhi B, Kwong J, Lo CM, Smedley JG, McClane BA, Aponte M, Gao Z, Sarno JL, Hinners J, Welch WR, Berkowitz RS, Mok SC, Garner EI. Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia (New York, N.Y.). 9: 304-14. PMID 17460774 DOI: 10.1593/Neo.07118  0.533
2007 Smedley JG, Uzal FA, McClane BA. Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin. Infection and Immunity. 75: 2381-90. PMID 17307943 DOI: 10.1128/Iai.01737-06  0.613
2004 Smedley JG, McClane BA. Fine mapping of the N-terminal cytotoxicity region of Clostridium perfringens enterotoxin by site-directed mutagenesis. Infection and Immunity. 72: 6914-23. PMID 15557612 DOI: 10.1128/Iai.72.12.6914-6923.2004  0.612
2004 Smedley JG, Fisher DJ, Sayeed S, Chakrabarti G, McClane BA. The enteric toxins of Clostridium perfringens. Reviews of Physiology, Biochemistry and Pharmacology. 152: 183-204. PMID 15517462 DOI: 10.1007/S10254-004-0036-2  0.581
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