Year |
Citation |
Score |
2024 |
Johnson JP, Focken T, Karimi Tari P, Dube C, Goodchild SJ, Andrez JC, Bankar G, Burford K, Chang E, Chowdhury S, Christabel J, Dean R, de Boer G, Dehnhardt C, Gong W, ... ... Shuart NG, et al. The contribution of Na1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na1.6 gain-of-function (GOF) mouse seizure control. British Journal of Pharmacology. PMID 38922847 DOI: 10.1111/bph.16481 |
0.346 |
|
2019 |
Focken T, Burford K, Grimwood ME, Zenova A, Andrez JC, Gong W, Wilson M, Taron M, Decker S, Lofstrand V, Chowdhury S, Shuart N, Lin S, Goodchild SJ, Young C, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. Journal of Medicinal Chemistry. PMID 31525968 DOI: 10.1021/Acs.Jmedchem.9B01032 |
0.353 |
|
2018 |
Bankar G, Goodchild SJ, Howard S, Nelkenbrecher K, Waldbrook M, Dourado M, Shuart NG, Lin S, Young C, Xie Z, Khakh K, Chang E, Sojo LE, Lindgren A, Chowdhury S, et al. Selective Na1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Reports. 24: 3133-3145. PMID 30231997 DOI: 10.1016/J.Celrep.2018.08.063 |
0.385 |
|
2018 |
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. The Journal of Biological Chemistry. PMID 30219789 DOI: 10.1074/Jbc.Ra118.004929 |
0.444 |
|
2018 |
Focken T, Chowdhury S, Zenova A, Grimwood ME, Chabot C, Sheng T, Hemeon I, Decker SM, Wilson M, Bichler P, Jia Q, Sun S, Young C, Lin S, Goodchild SJ, ... Shuart NG, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 29737846 DOI: 10.1021/Acs.Jmedchem.7B01826 |
0.319 |
|
2016 |
Focken T, Liu S, Chahal N, Dauphinais M, Grimwood ME, Chowdhury S, Hemeon I, Bichler P, Bogucki D, Waldbrook M, Bankar G, Sojo LE, Young C, Lin S, Shuart N, et al. Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models. Acs Medicinal Chemistry Letters. 7: 277-82. PMID 26985315 DOI: 10.1021/Acsmedchemlett.5B00447 |
0.339 |
|
2011 |
Shuart NG, Haitin Y, Camp SS, Black KD, Zagotta WN. Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels. Nature Communications. 2: 457. PMID 21878911 DOI: 10.1038/Ncomms1466 |
0.414 |
|
2011 |
Budzinski KL, Sgro AE, Fujimoto BS, Gadd JC, Shuart NG, Gonen T, Bajjaleih SM, Chiu DT. Synaptosomes as a platform for loading nanoparticles into synaptic vesicles. Acs Chemical Neuroscience. 2: 236-241. PMID 21666849 DOI: 10.1021/Cn200009N |
0.359 |
|
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