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Roger P. Leng, Ph.D. - Publications

Affiliations: 
Laboratory Medicine and Pathology University of Alberta, Edmonton, Alberta, Canada 
Area:
molecular biology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wu HH, Abou Zeinab R, Leng R. Regulation of p73 by Pirh2-AIP4 loop. Aging. PMID 34520394 DOI: 10.18632/aging.203537  0.433
2021 Wu HH, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP. Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation. Nucleic Acids Research. PMID 33619536 DOI: 10.1093/nar/gkab081  0.474
2021 Abou Zeinab R, Wu HH, Abuetabh Y, Leng S, Sergi C, Eisenstat DD, Leng RP. Pirh2, an E3 Ligase, Regulates the AIP4-p73 Regulatory Pathway by Modulating AIP4 Expression and Ubiquitination. Carcinogenesis. PMID 33569599 DOI: 10.1093/carcin/bgab009  0.524
2020 Burnett M, Abuetabh Y, Wronski A, Shen F, Persad S, Leng R, Eisenstat D, Sergi C. Graphene Oxide Nanoparticles Induce Apoptosis in wild-type and CRISPR/Cas9-IGF/IGFBP3 knocked-out Osteosarcoma Cells. Journal of Cancer. 11: 5007-5023. PMID 32742448 DOI: 10.7150/Jca.46464  0.341
2019 Japoni S, Song X, Leng R, Eisenstat D. BIOL-04. DISTAL-LESS/DLX2 HOMEOBOX GENE REGULATION OF CHEMOKINE RECEPTOR CXCR4 - ROLE IN MIGRATION IN FOREBRAIN DEVELOPMENT AND CNS TUMORS Neuro-Oncology. 21: ii66-ii67. DOI: 10.1093/Neuonc/Noz036.017  0.352
2018 Chai C, Wu H, Wang B, Eisenstat DD, Leng RP. MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells. Carcinogenesis. PMID 29985991 DOI: 10.1093/Carcin/Bgy092  0.377
2017 Wang B, Wu H, Chai C, Lewis J, Pichiorri F, Eisenstat DD, Pomeroy S, Leng RP. MicroRNA-1301 Suppresses Tumor Cell Migration and Invasion by Targeting the p53/UBE4B Pathway in Multiple Human Cancer Cells. Cancer Letters. PMID 28483517 DOI: 10.1016/J.Canlet.2017.04.038  0.571
2016 Armstrong SR, Wu H, Wang B, Abuetabh Y, Sergi C, Leng RP. The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System. International Journal of Molecular Sciences. 17. PMID 27929429 DOI: 10.3390/Ijms17122041  0.583
2016 Armstrong SR, Wang B, Abuetabh Y, Leng R. Abstract LB-022: The E3-ligase CHIP negatively regulates the expression and function of the tumor suppressor TAp63 through ubiquitination and subsequent proteasome-mediated degradation Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-022  0.569
2015 Du C, Wu H, Leng RP. UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget. PMID 26673821 DOI: 10.18632/Oncotarget.6555  0.516
2015 Wu H, Leng RP. MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function. Oncotarget. 6: 21479-92. PMID 26025930 DOI: 10.18632/Oncotarget.4086  0.568
2015 Al-Bahrani R, Nagamori S, Leng R, Petryk A, Sergi C. Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma Pathology and Oncology Research. 21: 901-908. DOI: 10.1007/S12253-015-9918-7  0.304
2015 Wu H, Leng RP. MDM2 mediates p73 ubiquitination: A new molecular mechanism for suppression of p73 function Oncotarget. 6: 21479-21492.  0.427
2013 Abou Zeinab R, Wu H, Sergi C, Leng RP. Residues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein Plos One. 8. PMID 24367557 DOI: 10.1371/Journal.Pone.0082803  0.402
2013 Bagashev A, Fan S, Mukerjee R, Claudio PP, Chabrashvili T, Leng RP, Benchimol S, Sawaya BE. Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein. Cell Cycle (Georgetown, Tex.). 12: 1569-77. PMID 23603988 DOI: 10.4161/Cc.24733  0.447
2013 Abou Zeinab RM, Leng R. The role of Pirh2 C-terminal residues and ubiquitin lysine chains in ubiquitination mechanism. Journal of Clinical Oncology. 31: 11110-11110. DOI: 10.1200/Jco.2013.31.15_Suppl.11110  0.465
2012 Zeinab RA, Wu H, Sergi C, Leng R. UBE4B: A promising regulatory molecule in neuronal death and survival International Journal of Molecular Sciences. 13: 16865-16879. PMID 23222733 DOI: 10.3390/Ijms131216865  0.377
2011 Wu H, Zeinab RA, Flores ER, Leng RP. Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination Molecular Cancer Research. 9: 1780-1790. PMID 21994467 DOI: 10.1158/1541-7786.Mcr-11-0157  0.562
2011 Wu H, Leng RP. UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation Cell Cycle. 10: 1912-1915. PMID 21558803 DOI: 10.4161/Cc.10.12.15882  0.56
2011 Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP. UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nature Medicine. 17: 347-55. PMID 21317885 DOI: 10.1038/Nm.2283  0.593
2006 Lin Y, Leng RP, Benchimol S. Identification of p53-regulated genes by the method of differential display. Methods in Molecular Biology (Clifton, N.J.). 317: 193-206. PMID 16264230 DOI: 10.1385/1-59259-968-0:193  0.452
2003 Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 112: 779-91. PMID 12654245 DOI: 10.1016/S0092-8674(03)00193-4  0.527
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