Rory Mitchell, Ph.D. - Publications

Centre for Integrative Physiology University of Edinburgh, Edinburgh, Scotland, United Kingdom 
GPCRs, Signalling pathways

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K, Ghosh A, Fullerton A, Menezes N, Dean J, Dunham J, Al-Azki S, Pryce G, Zandee S, Zhao C, ... ... Mitchell R, et al. Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis. Acta Neuropathologica. PMID 32572598 DOI: 10.1007/s00401-020-02179-x  0.68
2020 Mitchell R, Mikolajczak M, Kersten C, Fleetwood-Walker S. ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain. Neurobiology of Disease. 104961. PMID 32531343 DOI: 10.1016/j.nbd.2020.104961  0.68
2020 Sun L, Fleetwood-Walker S, Mitchell R, Joosten EA, Cheung CW. Prolonged analgesia by spinal cord stimulation following a spinal injury associated with activation of adult neural progenitors. Pain Practice : the Official Journal of World Institute of Pain. PMID 32474998 DOI: 10.1111/papr.12921  0.68
2019 Kersten C, Cameron MG, Bailey AG, Fallon MT, Laird BJ, Paterson V, Mitchell R, Fleetwood-Walker SM, Daly F, Mjåland S. Relief of Neuropathic Pain Through Epidermal Growth Factor Receptor Inhibition: A Randomized Proof-of-Concept Trial. Pain Medicine (Malden, Mass.). PMID 31106835 DOI: 10.1093/pm/pnz101  0.52
2019 Mitchell R, Campbell G, Mikolajczak M, McGill K, Mahad D, Fleetwood-Walker SM. A Targeted Mutation Disrupting Mitochondrial Complex IV Function in Primary Afferent Neurons Leads to Pain Hypersensitivity Through P2Y Receptor Activation. Molecular Neurobiology. PMID 30689196 DOI: 10.1007/s12035-018-1455-4  0.52
2017 Greaves E, Horne AW, Jerina H, Mikolajczak M, Hilferty L, Mitchell R, Fleetwood-Walker SM, Saunders PT. EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis. Scientific Reports. 7: 44169. PMID 28281561 DOI: 10.1038/srep44169  0.68
2014 Vinuela-Fernandez I, Sun L, Jerina H, Curtis J, Allchorne A, Gooding H, Rosie R, Holland P, Tas B, Mitchell R, Fleetwood-Walker S. The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity. Neuropharmacology. 79: 136-51. PMID 24269608 DOI: 10.1016/j.neuropharm.2013.11.006  0.68
2014 Sande TA, Scott AC, Laird BJ, Wan HI, Fleetwood-Walker SM, Kaasa S, Klepstad P, Mitchell R, Murray GD, Colvin LA, Fallon MT. The characteristics of physical activity and gait in patients receiving radiotherapy in cancer induced bone pain. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 111: 18-24. PMID 24231246 DOI: 10.1016/j.radonc.2013.10.023  0.68
2013 Sun L, Gooding HL, Brunton PJ, Russell JA, Mitchell R, Fleetwood-Walker S. Phospholipase D-mediated hypersensitivity at central synapses is associated with abnormal behaviours and pain sensitivity in rats exposed to prenatal stress. The International Journal of Biochemistry & Cell Biology. 45: 2706-12. PMID 23932932 DOI: 10.1016/j.biocel.2013.07.017  0.68
2013 Barclay Z, Dickson L, Robertson D, Johnson M, Holland P, Rosie R, Sun L, Jerina H, Lutz E, Fleetwood-Walker S, Mitchell R. Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor. Cellular Signalling. 25: 814-21. PMID 23314176 DOI: 10.1016/j.cellsig.2013.01.004  0.68
2012 Allchorne AJ, Gooding HL, Mitchell R, Fleetwood-Walker SM. A novel model of combined neuropathic and inflammatory pain displaying long-lasting allodynia and spontaneous pain-like behaviour. Neuroscience Research. 74: 230-8. PMID 23131427 DOI: 10.1016/j.neures.2012.10.006  0.68
2012 Fleetwood-Walker S, Sun L, Jerina H, Mitchell R. Assessment of animal pain and mechanism-based strategies for its reversal. Veterinary Journal (London, England : 1997). 193: 305-6. PMID 22884986 DOI: 10.1016/j.tvjl.2012.07.017  0.68
2011 Barclay Z, Dickson L, Robertson DN, Johnson MS, Holland PJ, Rosie R, Sun L, Fleetwood-Walker S, Lutz EM, Mitchell R. 5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail. The Biochemical Journal. 436: 651-60. PMID 21410433 DOI: 10.1042/BJ20101844  0.68
2010 Storey DJ, Colvin LA, Mackean MJ, Mitchell R, Fleetwood-Walker SM, Fallon MT. Reversal of dose-limiting carboplatin-induced peripheral neuropathy with TRPM8 activator, menthol, enables further effective chemotherapy delivery. Journal of Pain and Symptom Management. 39: e2-4. PMID 20538177 DOI: 10.1016/j.jpainsymman.2010.02.004  0.68
2010 Arbuckle MI, Komiyama NH, Delaney A, Coba M, Garry EM, Rosie R, Allchorne AJ, Forsyth LH, Bence M, Carlisle HJ, O'Dell TJ, Mitchell R, Fleetwood-Walker SM, Grant SG. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. Embo Reports. 11: 473-8. PMID 20467438 DOI: 10.1038/embor.2010.63  0.68
2010 Reynolds RM, Strachan MW, Labad J, Lee AJ, Frier BM, Fowkes FG, Mitchell R, Seckl JR, Deary IJ, Walker BR, Price JF. Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Diabetes Care. 33: 714-20. PMID 20097784 DOI: 10.2337/dc09-1796  0.68
2010 Marioni RE, Strachan MW, Reynolds RM, Lowe GD, Mitchell RJ, Fowkes FG, Frier BM, Lee AJ, Butcher I, Rumley A, Murray GD, Deary IJ, Price JF. Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes. 59: 710-3. PMID 19959761 DOI: 10.2337/db09-1163  0.68
2009 Delaney A, Colvin LA, Fallon MT, Dalziel RG, Mitchell R, Fleetwood-Walker SM. Postherpetic neuralgia: from preclinical models to the clinic. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 630-7. PMID 19789068 DOI: 10.1016/j.nurt.2009.07.005  0.68
2009 Strachan MW, Reynolds RM, Frier BM, Mitchell RJ, Price JF. The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies. Diabetes, Obesity & Metabolism. 11: 407-14. PMID 19422401 DOI: 10.1111/j.1463-1326.2008.00963.x  0.68
2008 Price JF, Reynolds RM, Mitchell RJ, Williamson RM, Fowkes FG, Deary IJ, Lee AJ, Frier BM, Hayes PC, Strachan MW. The Edinburgh Type 2 Diabetes Study: study protocol. Bmc Endocrine Disorders. 8: 18. PMID 19077235 DOI: 10.1186/1472-6823-8-18  0.68
2008 Strachan MW, Reynolds RM, Frier BM, Mitchell RJ, Price JF. The relationship between type 2 diabetes and dementia. British Medical Bulletin. 88: 131-46. PMID 19029150 DOI: 10.1093/bmb/ldn042  0.68
2008 Colvin LA, Johnson PR, Mitchell R, Fleetwood-Walker SM, Fallon M. From bench to bedside: a case of rapid reversal of bortezomib-induced neuropathic pain by the TRPM8 activator, menthol. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 4519-20. PMID 18802169 DOI: 10.1200/JCO.2008.18.5017  0.68
2006 Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, Fleetwood-Walker SM, Mitchell R. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Current Biology : Cb. 16: 1591-605. PMID 16920620 DOI: 10.1016/j.cub.2006.07.061  0.68
2006 Johnson MS, Robertson DN, Holland PJ, Lutz EM, Mitchell R. Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF). Cellular Signalling. 18: 1793-800. PMID 16545942 DOI: 10.1016/j.cellsig.2006.02.002  0.68
2005 Wilson JA, Garry EM, Anderson HA, Rosie R, Colvin LA, Mitchell R, Fleetwood-Walker SM. NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists. Pain. 117: 421-32. PMID 16150544 DOI: 10.1016/j.pain.2005.07.005  0.68
2003 Robertson DN, Johnson MS, Moggach LO, Holland PJ, Lutz EM, Mitchell R. Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor. Molecular Pharmacology. 64: 1239-50. PMID 14573774 DOI: 10.1124/mol.64.5.1239  0.68
2003 Garry EM, Moss A, Rosie R, Delaney A, Mitchell R, Fleetwood-Walker SM. Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit. Molecular and Cellular Neurosciences. 24: 10-22. PMID 14550765 DOI: 10.1016/S1044-7431(03)00134-9  0.68
2003 Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS. ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. The Journal of Biological Chemistry. 278: 33818-30. PMID 12799371 DOI: 10.1074/jbc.M305825200  0.68
2003 Johnson MS, Lutz EM, Firbank S, Holland PJ, Mitchell R. Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporter. Cellular Signalling. 15: 803-11. PMID 12781873 DOI: 10.1016/S0898-6568(03)00013-5  0.68
2003 Garry EM, Moss A, Delaney A, O'Neill F, Blakemore J, Bowen J, Husi H, Mitchell R, Grant SG, Fleetwood-Walker SM. Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Current Biology : Cb. 13: 321-8. PMID 12593798 DOI: 10.1016/S0960-9822(03)00084-8  0.68
2002 Moss A, Blackburn-Munro G, Garry EM, Blakemore JA, Dickinson T, Rosie R, Mitchell R, Fleetwood-Walker SM. A role of the ubiquitin-proteasome system in neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1363-72. PMID 11850463  0.68
2000 Johnson MS, Lutz EM, MacKenzie CJ, Wolbers WB, Robertson DN, Holland PJ, Mitchell R. Gonadotropin-Releasing Hormone Receptor Activation of Extracellular Signal-Regulated Kinase and Tyrosine Kinases in Transfected GH3 Cells and in αT3-1 Cells. Endocrinology. 141: 3087-3097. PMID 28201222 DOI: 10.1210/endo.141.9.7657  0.64
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