| Year |
Citation |
Score |
| 2022 |
Lin SY, Tien YW, Ke YY, Chang YC, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone. Bioorganic Chemistry. 105905. PMID 35710525 DOI: 10.1016/j.bioorg.2022.105905 |
0.395 |
|
| 2021 |
Xu C, Fan W, Zhang Y, Loh HH, Law PY. Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway. Stem Cells (Dayton, Ohio). PMID 33452745 DOI: 10.1002/stem.3334 |
0.365 |
|
| 2020 |
Kibaly C, Alderete JA, Liu SH, Nasef HS, Law PY, Evans CJ, Cahill CM. Oxycodone in the Opioid Epidemic: High 'Liking', 'Wanting', and Abuse Liability. Cellular and Molecular Neurobiology. PMID 33245509 DOI: 10.1007/s10571-020-01013-y |
0.385 |
|
| 2020 |
Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cellular and Molecular Neurobiology. PMID 32989585 DOI: 10.1007/s10571-020-00970-8 |
0.372 |
|
| 2020 |
Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Reports. 30: 3625-3631.e6. PMID 32187535 DOI: 10.1016/J.Celrep.2020.02.075 |
0.641 |
|
| 2020 |
Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, et al. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32154623 DOI: 10.1096/Fj.201902873R |
0.63 |
|
| 2019 |
Yang PP, Yeh TK, Loh HH, Law PY, Wang Y, Tao PL. Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice. European Journal of Pharmacology. PMID 30959048 DOI: 10.1016/J.Ejphar.2019.04.009 |
0.476 |
|
| 2019 |
Zhao LX, Ge YH, Li JB, Xiong CH, Law PY, Xu JR, Qiu Y, Chen HZ. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802351R. PMID 30794430 DOI: 10.1096/Fj.201802351R |
0.452 |
|
| 2019 |
Chao PK, Chang HF, Ou LC, Chuang JY, Lee PT, Chang WT, Chen SC, Ueng SH, Hsu JT, Tao PL, Law PY, Loh HH, Yeh SH. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Scientific Reports. 9: 2405. PMID 30787373 DOI: 10.1038/s41598-019-39555-x |
0.489 |
|
| 2019 |
Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, et al. The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone. European Journal of Medicinal Chemistry. 167: 312-323. PMID 30776693 DOI: 10.1016/j.ejmech.2019.01.063 |
0.412 |
|
| 2018 |
Kibaly C, Xu C, Cahill CM, Evans CJ, Law PY. Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect. Nature Reviews. Neuroscience. PMID 30518959 DOI: 10.1038/S41583-018-0092-2 |
0.404 |
|
| 2018 |
Zhao LX, Ge YH, Xiong CH, Tang L, Yan YH, Law PY, Qiu Y, Chen HZ. M1 muscarinic receptor facilitates cognitive function by interplay with AMPA receptor GluA1 subunit. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800029R. PMID 29509512 DOI: 10.1096/Fj.201800029R |
0.355 |
|
| 2017 |
Zhang L, Kibaly C, Wang YJ, Xu C, Song KY, W McGarrah P, Loh HH, Liu JG, Law PY. Src-dependent phosphorylation of μ-opioid receptor at Tyr(336) modulates opiate withdrawal. Embo Molecular Medicine. PMID 28818835 DOI: 10.15252/emmm.201607324 |
0.447 |
|
| 2017 |
Lee DS, Law PY, Ln W, Loh HH, Song KY, Choi HS. Differential regulation of mouse and human Mu opioid receptor gene depends on the single stranded DNA structure of its promoter and α-complex protein 1. Biomedical Reports. 6: 532-538. PMID 28529734 DOI: 10.3892/Br.2017.877 |
0.426 |
|
| 2017 |
Chao PK, Ueng SH, Ou LC, Yeh TK, Chang WT, Chang HF, Chen SC, Tao PL, Law PY, Loh HH, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH. 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine. Anesthesiology. PMID 28212204 DOI: 10.1097/ALN.0000000000001568 |
0.508 |
|
| 2017 |
Kibaly C, Lin HY, Loh HH, Law PY. Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo. Pharmacological Research. PMID 28179123 DOI: 10.1016/j.phrs.2017.01.033 |
0.438 |
|
| 2017 |
Wagley Y, Law PY, Wei LN, Loh HH. Epigenetic activation of mu opioid receptor (MOR) gene via increased expression and function of mitogen- and stress-activated protein kinase 1 (MSK1). Molecular Pharmacology. PMID 28153853 DOI: 10.1124/Mol.116.106567 |
0.533 |
|
| 2016 |
Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH. Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element binding protein (AUF1) and poly A binding protein (PABP). Gene. PMID 27836661 DOI: 10.1016/j.gene.2016.11.003 |
0.312 |
|
| 2016 |
Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, et al. Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists. European Journal of Medicinal Chemistry. 126: 202-217. PMID 27776274 DOI: 10.1016/j.ejmech.2016.09.003 |
0.459 |
|
| 2016 |
Yang PP, Yeh GC, Yeh TK, Xi J, Loh HH, Law PY, Tao PL. Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice. Pharmacological Research. PMID 27496654 DOI: 10.1016/j.phrs.2016.05.034 |
0.544 |
|
| 2016 |
Song KY, Choi HS, Law PY, Wei LN, Loh HH. Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1. Journal of Cellular Physiology. PMID 27292014 DOI: 10.1002/jcp.25455 |
0.41 |
|
| 2016 |
Zhang Y, Loh HH, Law PY. Effect of Opioid on Adult Hippocampal Neurogenesis. Thescientificworldjournal. 2016: 2601264. PMID 27127799 DOI: 10.1155/2016/2601264 |
0.363 |
|
| 2015 |
Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ, Qiu Y. Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12. Cns Neuroscience & Therapeutics. 21: 591-8. PMID 26096047 DOI: 10.1111/Cns.12409 |
0.594 |
|
| 2015 |
Kibaly C, Kam AY, Loh HH, Law PY. Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion. Biological Psychiatry. PMID 26049209 DOI: 10.1016/J.Biopsych.2015.04.019 |
0.454 |
|
| 2015 |
Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH. Analysis of epigenetic mechanisms regulating opioid receptor gene transcription. Methods in Molecular Biology (Clifton, N.J.). 1230: 39-51. PMID 25293314 DOI: 10.1007/978-1-4939-1708-2_3 |
0.484 |
|
| 2015 |
Wang Y, Wang YX, Liu T, Law PY, Loh HH, Qiu Y, Chen HZ. μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling. Cns Neuroscience & Therapeutics. 21: 8-14. PMID 25146548 DOI: 10.1111/cns.12316 |
0.427 |
|
| 2015 |
Kao JH, Gao MJ, Yang PP, Law PY, Loh HH, Tao PL. Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord. British Journal of Pharmacology. 172: 630-41. PMID 24866991 DOI: 10.1111/bph.12790 |
0.447 |
|
| 2014 |
Lee PT, Chao PK, Ou LC, Chuang JY, Lin YC, Chen SC, Chang HF, Law PY, Loh HH, Chao YS, Su TP, Yeh SH. Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling. Nucleic Acids Research. 42: 13012-25. PMID 25361975 DOI: 10.1093/nar/gku1016 |
0.368 |
|
| 2014 |
Cheng MF, Ou LC, Chen SC, Chang WT, Law PY, Loh HH, Chao YS, Shih C, Yeh SH, Ueng SH. Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists. Bioorganic & Medicinal Chemistry. 22: 4694-703. PMID 25087049 DOI: 10.1016/J.Bmc.2014.07.012 |
0.593 |
|
| 2014 |
Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H. Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms. Biological Psychiatry. 76: 775-84. PMID 24993058 DOI: 10.1016/j.biopsych.2014.05.013 |
0.371 |
|
| 2014 |
Glück L, Loktev A, Moulédous L, Mollereau C, Law PY, Schulz S. Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5. Biological Psychiatry. 76: 767-74. PMID 24629717 DOI: 10.1016/J.Biopsych.2014.01.021 |
0.534 |
|
| 2014 |
Yan YH, Wang Y, Zhao LX, Jiang S, Loh HH, Law PY, Chen HZ, Qiu Y. Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. Neuroscience Letters. 566: 231-5. PMID 24607931 DOI: 10.1016/J.Neulet.2014.02.059 |
0.651 |
|
| 2014 |
Qiu Y, Zhao W, Wang Y, Xu JR, Huie E, Jiang S, Yan YH, Loh HH, Chen HZ, Law PY. FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor. Molecular Pharmacology. 85: 37-49. PMID 24113748 DOI: 10.1124/mol.113.087825 |
0.524 |
|
| 2013 |
Zhang L, Loh HH, Law PY. A novel noncanonical signaling pathway for the μ-opioid receptor. Molecular Pharmacology. 84: 844-53. PMID 24061856 DOI: 10.1124/Mol.113.088278 |
0.544 |
|
| 2013 |
Law PY, Reggio PH, Loh HH. Opioid receptors: toward separation of analgesic from undesirable effects. Trends in Biochemical Sciences. 38: 275-82. PMID 23598157 DOI: 10.1016/J.Tibs.2013.03.003 |
0.603 |
|
| 2013 |
Wagley Y, Hwang CK, Lin HY, Kam AF, Law PY, Loh HH, Wei LN. Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells. Biochimica Et Biophysica Acta. 1833: 1476-88. PMID 23485395 DOI: 10.1016/J.Bbamcr.2013.02.017 |
0.494 |
|
| 2013 |
Zheng H, Loh HH, Law PY. Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods in Enzymology. 522: 391-408. PMID 23374194 DOI: 10.1016/B978-0-12-407865-9.00018-2 |
0.52 |
|
| 2013 |
Song KY, Choi HS, Law PY, Wei LN, Loh HH. Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation. Rna Biology. 10: 256-66. PMID 23353576 DOI: 10.4161/rna.23022 |
0.511 |
|
| 2013 |
Zheng H, Zhang Y, Li W, Loh HH, Law PY. NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 770-7. PMID 23303051 DOI: 10.1038/npp.2012.242 |
0.37 |
|
| 2013 |
Wu Q, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, Wei LN. MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 522-35. PMID 23085997 DOI: 10.1096/Fj.12-213439 |
0.448 |
|
| 2013 |
Pearsall EA, Law P, Reggio PH. The Unusual Phenotype of the Mu Opioid Receptor S4.54A Mutant:An Exploration of Structural Origins using Conformational Memories Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2277 |
0.402 |
|
| 2012 |
Zheng H, Law PY, Loh HH. Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Frontiers in Genetics. 3: 113. PMID 22715342 DOI: 10.3389/fgene.2012.00113 |
0.416 |
|
| 2012 |
Miller EC, Zhang L, Dummer BW, Cariveau DR, Loh H, Law PY, Liao D. Differential modulation of drug-induced structural and functional plasticity of dendritic spines. Molecular Pharmacology. 82: 333-43. PMID 22596350 DOI: 10.1124/Mol.112.078162 |
0.352 |
|
| 2012 |
Zheng H, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, Law PY. Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. Bmc Cell Biology. 13: 6. PMID 22429589 DOI: 10.1186/1471-2121-13-6 |
0.67 |
|
| 2012 |
Chou SH, Kao JH, Tao PL, Law PY, Loh HH. Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway. Synapse (New York, N.Y.). 66: 694-704. PMID 22407757 DOI: 10.1002/syn.21555 |
0.346 |
|
| 2012 |
Zheng H, Zou H, Liu X, Chu J, Zhou Y, Loh HH, Law PY. Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. Journal of Lipid Research. 53: 1153-62. PMID 22377533 DOI: 10.1194/Jlr.M024455 |
0.675 |
|
| 2012 |
Lin HY, Law PY, Loh HH. Activation of protein kinase C (PKC)α or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdose. The Journal of Pharmacology and Experimental Therapeutics. 341: 115-25. PMID 22228806 DOI: 10.1124/jpet.111.188235 |
0.362 |
|
| 2012 |
Song KY, Choi HS, Law PY, Wei LN, Loh HH. Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F. Cellular and Molecular Life Sciences : Cmls. 69: 599-610. PMID 21739230 DOI: 10.1007/s00018-011-0761-z |
0.381 |
|
| 2012 |
Pearsall E, Law P, Reggio PH. Molecular Determinants for a Mutant Mu-Opioid Receptor in which Naloxone Acts as a Partial Agonist Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2572 |
0.444 |
|
| 2011 |
Choe CY, Kim H, Dong J, van Wijnen AJ, Law PY, Loh HH. The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element. Gene. 487: 52-61. PMID 21839154 DOI: 10.1016/j.gene.2011.07.026 |
0.363 |
|
| 2011 |
Qiu Y, Wang Y, Law PY, Chen HZ, Loh HH. Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts. Molecular Pharmacology. 80: 210-8. PMID 21518774 DOI: 10.1124/mol.110.070870 |
0.398 |
|
| 2011 |
Zheng H, Chu J, Zhang Y, Loh HH, Law PY. Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. The Journal of Biological Chemistry. 286: 12724-33. PMID 21292762 DOI: 10.1074/Jbc.M110.177089 |
0.725 |
|
| 2011 |
Kim do K, Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH. p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. Journal of Neurochemistry. 116: 1077-87. PMID 21198637 DOI: 10.1111/J.1471-4159.2010.07163.X |
0.515 |
|
| 2011 |
Choe CY, Dong J, Law PY, Loh HH. Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters. Gene. 471: 27-36. PMID 20946943 DOI: 10.1016/J.Gene.2010.10.004 |
0.443 |
|
| 2010 |
Kam AY, Liao D, Loh HH, Law PY. Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15304-16. PMID 21068335 DOI: 10.1523/Jneurosci.4255-10.2010 |
0.458 |
|
| 2010 |
Sanchez-Simon FM, Zhang XX, Loh HH, Law PY, Rodriguez RE. Morphine regulates dopaminergic neuron differentiation via miR-133b. Molecular Pharmacology. 78: 935-42. PMID 20716624 DOI: 10.1124/Mol.110.066837 |
0.486 |
|
| 2010 |
Kao JH, Chen SL, Ma HI, Law PY, Tao PL, Loh HH. Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm. The Journal of Pharmacology and Experimental Therapeutics. 334: 739-45. PMID 20554907 DOI: 10.1124/Jpet.109.165399 |
0.516 |
|
| 2010 |
Zheng H, Zeng Y, Chu J, Kam AY, Loh HH, Law PY. Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8102-10. PMID 20554861 DOI: 10.1523/Jneurosci.6069-09.2010 |
0.72 |
|
| 2010 |
Zheng H, Chu J, Zeng Y, Loh HH, Law PY. Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. The Journal of Biological Chemistry. 285: 21994-2002. PMID 20457614 DOI: 10.1074/Jbc.M110.112607 |
0.647 |
|
| 2010 |
Chen SL, Ma HI, Han JM, Lu RB, Tao PL, Law PY, Loh HH. Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene. Journal of Biomedical Science. 17: 28. PMID 20403204 DOI: 10.1186/1423-0127-17-28 |
0.425 |
|
| 2010 |
Chen YL, Monteith N, Law PY, Loh HH. Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation. Biochemical and Biophysical Research Communications. 396: 294-8. PMID 20399742 DOI: 10.1016/J.Bbrc.2010.04.083 |
0.38 |
|
| 2010 |
Zheng H, Loh HH, Law PY. Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. Iubmb Life. 62: 112-9. PMID 20058265 DOI: 10.1002/iub.293 |
0.311 |
|
| 2010 |
Chu J, Zheng H, Zhang Y, Loh HH, Law PY. Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cellular Signalling. 22: 684-96. PMID 20043990 DOI: 10.1016/J.Cellsig.2009.12.003 |
0.764 |
|
| 2010 |
Tao PL, Law PY, Loh HH. Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor. Iubmb Life. 62: 103-11. PMID 20039371 DOI: 10.1002/iub.292 |
0.494 |
|
| 2010 |
Zheng H, Zeng Y, Zhang X, Chu J, Loh HH, Law PY. mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Molecular Pharmacology. 77: 102-9. PMID 19854889 DOI: 10.1124/Mol.109.060848 |
0.647 |
|
| 2010 |
Song KY, Kim CS, Hwang CK, Choi HS, Law PY, Wei LN, Loh HH. uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression. Journal of Cellular and Molecular Medicine. 14: 1113-24. PMID 19438807 DOI: 10.1111/j.1582-4934.2009.00734.x |
0.429 |
|
| 2010 |
Poole E, Hurst D, Reggio P, Law P. Construction of a μ-Opioid Receptor Model using Conformational Memories Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3541 |
0.484 |
|
| 2009 |
Ge X, Qiu Y, Loh HH, Law PY. GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft. The Journal of Biological Chemistry. 284: 36521-34. PMID 19861419 DOI: 10.1074/Jbc.M109.024109 |
0.592 |
|
| 2009 |
Song KY, Choi HS, Hwang CK, Kim CS, Law PY, Wei LN, Loh HH. Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1). Cellular and Molecular Life Sciences : Cmls. 66: 2933-42. PMID 19609488 DOI: 10.1007/s00018-009-0082-7 |
0.436 |
|
| 2009 |
Hwang CK, Song KY, Kim CS, Choi HS, Guo XH, Law PY, Wei LN, Loh HH. Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor. Journal of Cellular and Molecular Medicine. 13: 3591-615. PMID 19602036 DOI: 10.1111/j.1582-4934.2008.00535.x |
0.305 |
|
| 2009 |
Lin H, Higgins P, Loh HH, Law PY, Liao D. Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2097-111. PMID 19295508 DOI: 10.1038/Npp.2009.34 |
0.505 |
|
| 2009 |
Ge X, Loh HH, Law PY. mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I. Molecular Pharmacology. 75: 1307-16. PMID 19289571 DOI: 10.1124/Mol.108.054064 |
0.597 |
|
| 2009 |
Choi HS, Hwang CK, Song KY, Law PY, Wei LN, Loh HH. Poly(C)-binding proteins as transcriptional regulators of gene expression. Biochemical and Biophysical Research Communications. 380: 431-6. PMID 19284986 DOI: 10.1016/J.Bbrc.2009.01.136 |
0.311 |
|
| 2009 |
Wu Q, Zhang L, Law PY, Wei LN, Loh HH. Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b. Molecular Pharmacology. 75: 744-50. PMID 19144786 DOI: 10.1124/Mol.108.053462 |
0.566 |
|
| 2009 |
Zhang L, Zhao H, Qiu Y, Loh HH, Law PY. Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. The Journal of Biological Chemistry. 284: 1990-2000. PMID 19029294 DOI: 10.1074/Jbc.M807971200 |
0.535 |
|
| 2009 |
Qiu Y, Loh H, Law P. Opioid receptor delta Afcs-Nature Molecule Pages. DOI: 10.1038/Mp.A001699.01 |
0.633 |
|
| 2008 |
Wu Q, Law PY, Wei LN, Loh HH. Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4085-95. PMID 18716031 DOI: 10.1096/Fj.08-108175 |
0.392 |
|
| 2008 |
Kim CS, Hwang CK, Song KY, Choi HS, Kim do K, Law PY, Wei LN, Loh HH. Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation. Biochimica Et Biophysica Acta. 1783: 1835-46. PMID 18657578 DOI: 10.1016/j.bbamcr.2008.06.019 |
0.331 |
|
| 2008 |
Zheng H, Chu J, Qiu Y, Loh HH, Law PY. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proceedings of the National Academy of Sciences of the United States of America. 105: 9421-6. PMID 18599439 DOI: 10.1073/Pnas.0802253105 |
0.668 |
|
| 2008 |
Chu J, Zheng H, Loh HH, Law PY. Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cellular Signalling. 20: 1616-24. PMID 18558479 DOI: 10.1016/J.Cellsig.2008.05.004 |
0.759 |
|
| 2008 |
Choi HS, Song KY, Hwang CK, Kim CS, Law PY, Wei LN, Loh HH. A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene. Molecular & Cellular Proteomics : McP. 7: 1517-29. PMID 18453338 DOI: 10.1074/mcp.M800052-MCP200 |
0.347 |
|
| 2008 |
Chen YL, Law PY, Loh HH. The other side of the opioid story: modulation of cell growth and survival signaling. Current Medicinal Chemistry. 15: 772-8. PMID 18393846 DOI: 10.2174/092986708783955518 |
0.467 |
|
| 2008 |
Chen YL, Law PY, Loh HH. NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression. Biochemical and Biophysical Research Communications. 368: 755-60. PMID 18269915 DOI: 10.1016/J.Bbrc.2008.01.164 |
0.41 |
|
| 2008 |
Choi HS, Hwang CK, Kim CS, Song KY, Law PY, Loh HH, Wei LN. Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1. Journal of Cellular and Molecular Medicine. 12: 2319-33. PMID 18266974 DOI: 10.1111/j.1582-4934.2008.00259.x |
0.363 |
|
| 2008 |
Zheng H, Loh HH, Law PY. Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation. Molecular Pharmacology. 73: 178-90. PMID 17947509 DOI: 10.1124/Mol.107.039842 |
0.479 |
|
| 2007 |
Chen SL, Ma HI, Han JM, Tao PL, Law PY, Loh HH. dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm. Proceedings of the National Academy of Sciences of the United States of America. 104: 20096-101. PMID 18056815 DOI: 10.1073/Pnas.0703409104 |
0.501 |
|
| 2007 |
Choi HS, Kim CS, Hwang CK, Song KY, Law PY, Wei LN, Loh HH. Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3963-73. PMID 17625070 DOI: 10.1096/Fj.07-8561Com |
0.408 |
|
| 2007 |
Qiu Y, Loh HH, Law PY. Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization. The Journal of Biological Chemistry. 282: 22315-23. PMID 17565992 DOI: 10.1074/jbc.M611258200 |
0.321 |
|
| 2007 |
Liao D, Grigoriants OO, Wang W, Wiens K, Loh HH, Law PY. Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors. Molecular and Cellular Neurosciences. 35: 456-69. PMID 17513124 DOI: 10.1016/J.Mcn.2007.04.007 |
0.507 |
|
| 2007 |
Hwang CK, Song KY, Kim CS, Choi HS, Guo XH, Law PY, Wei LN, Loh HH. Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. Molecular and Cellular Biology. 27: 4720-36. PMID 17452465 DOI: 10.1128/Mcb.00073-07 |
0.393 |
|
| 2007 |
Song KY, Hwang CK, Kim CS, Choi HS, Law PY, Wei LN, Loh HH. Translational repression of mouse mu opioid receptor expression via leaky scanning. Nucleic Acids Research. 35: 1501-13. PMID 17284463 DOI: 10.1093/nar/gkm034 |
0.383 |
|
| 2007 |
Chen YL, Law PY, Loh HH. Action of NF-kappaB on the delta opioid receptor gene promoter. Biochemical and Biophysical Research Communications. 352: 818-22. PMID 17150179 DOI: 10.1016/J.Bbrc.2006.11.103 |
0.444 |
|
| 2007 |
Liao D, Grigoriants OO, Loh HH, Law PY. Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons. Journal of Neurophysiology. 97: 1485-94. PMID 17122315 DOI: 10.1152/Jn.00790.2006 |
0.379 |
|
| 2007 |
Chu J, Loh HH, Law P. Agonist‐direct Mu‐opioid Receptor Desensitization The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A426-C |
0.675 |
|
| 2006 |
Chen YL, Law PY, Loh HH. Nuclear factor kappaB signaling in opioid functions and receptor gene expression. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 270-9. PMID 18040804 DOI: 10.1007/S11481-006-9028-0 |
0.553 |
|
| 2006 |
Choi HS, Kim CS, Hwang CK, Song KY, Wang W, Qiu Y, Law PY, Wei LN, Loh HH. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochemical and Biophysical Research Communications. 343: 1132-40. PMID 16580639 DOI: 10.1016/j.bbrc.2006.03.084 |
0.507 |
|
| 2006 |
Zhang L, Tetrault J, Wang W, Loh HH, Law PY. Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells. Molecular Pharmacology. 69: 1810-9. PMID 16525132 DOI: 10.1124/Mol.105.021352 |
0.508 |
|
| 2006 |
Zhao H, Loh HH, Law PY. Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization. Molecular Pharmacology. 69: 1421-32. PMID 16415176 DOI: 10.1124/Mol.105.020024 |
0.598 |
|
| 2006 |
Chen YL, Law PY, Loh HH. Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression. The Journal of Biological Chemistry. 281: 3067-74. PMID 16316997 DOI: 10.1074/jbc.M506721200 |
0.363 |
|
| 2005 |
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proceedings of the National Academy of Sciences of the United States of America. 102: 19208-13. PMID 16365317 DOI: 10.1073/Pnas.0506627102 |
0.61 |
|
| 2005 |
Kim SS, Pandey KK, Choi HS, Kim SY, Law PY, Wei LN, Loh HH. Poly(C) binding protein family is a transcription factor in mu-opioid receptor gene expression. Molecular Pharmacology. 68: 729-36. PMID 15933215 DOI: 10.1124/Mol.105.012245 |
0.448 |
|
| 2005 |
Wu Q, Hwang CK, Yao S, Law PY, Loh HH, Wei LN. A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal. Molecular Pharmacology. 68: 279-85. PMID 15879516 DOI: 10.1124/Mol.105.012567 |
0.448 |
|
| 2005 |
Liao D, Lin H, Law PY, Loh HH. Mu-opioid receptors modulate the stability of dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 102: 1725-30. PMID 15659552 DOI: 10.1073/Pnas.0406797102 |
0.498 |
|
| 2005 |
Law PY, Erickson-Herbrandson LJ, Zha QQ, Solberg J, Chu J, Sarre A, Loh HH. Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. The Journal of Biological Chemistry. 280: 11152-64. PMID 15657030 DOI: 10.1074/Jbc.M500171200 |
0.768 |
|
| 2005 |
Claude-Geppert PA, Liu J, Solberg J, Erickson-Herbrandson LJ, Loh HH, Law PY. Antagonist efficacy in MORS196L mutant is affected by the interaction between transmembrane domains of the opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 313: 216-26. PMID 15579496 DOI: 10.1124/Jpet.104.076505 |
0.644 |
|
| 2004 |
Chen YL, Law PY, Loh HH. Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells. Cancer Research. 64: 8723-30. PMID 15574783 DOI: 10.1158/0008-5472.Can-03-3091 |
0.341 |
|
| 2004 |
Law PY, Loh HH, Wei LN. Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence. Neuropharmacology. 47: 300-11. PMID 15464146 DOI: 10.1016/J.Neuropharm.2004.07.013 |
0.594 |
|
| 2004 |
Kim CS, Hwang CK, Choi HS, Song KY, Law PY, Wei LN, Loh HH. Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene. The Journal of Biological Chemistry. 279: 46464-73. PMID 15322094 DOI: 10.1074/Jbc.M403633200 |
0.393 |
|
| 2004 |
Wei LN, Law PY, Loh HH. Post-transcriptional regulation of opioid receptors in the nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 9: 1665-79. PMID 14977578 |
0.53 |
|
| 2003 |
Portoghese PS, Law PY, Loh HH. Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens. European Journal of Pharmacology. 478: 207-10. PMID 14575806 DOI: 10.1016/J.Ejphar.2003.08.041 |
0.57 |
|
| 2003 |
Qiu Y, Law PY, Loh HH. Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation. The Journal of Biological Chemistry. 278: 36733-9. PMID 12860981 DOI: 10.1074/jbc.M305857200 |
0.522 |
|
| 2003 |
Wang W, Loh HH, Law PY. The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells. The Journal of Biological Chemistry. 278: 36848-58. PMID 12851402 DOI: 10.1074/Jbc.M301540200 |
0.653 |
|
| 2003 |
Chaipatikul V, Erickson-Herbrandson LJ, Loh HH, Law PY. Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands. Molecular Pharmacology. 64: 32-41. PMID 12815158 DOI: 10.1124/Mol.64.1.32 |
0.765 |
|
| 2003 |
Chaipatikul V, Loh HH, Law PY. Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain. The Journal of Pharmacology and Experimental Therapeutics. 305: 909-18. PMID 12626655 DOI: 10.1124/Jpet.102.046219 |
0.768 |
|
| 2003 |
Yang W, Law PY, Guo X, Loh HH. In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proceedings of the National Academy of Sciences of the United States of America. 100: 2117-21. PMID 12525693 DOI: 10.1073/Pnas.0334906100 |
0.617 |
|
| 2003 |
Chaipatikul V, Erickson-Herbrandson LJ, Loh HH, Law P. Erratum: Rescuing the traffic-deficient mutants of rat μ-opioid receptors with hydrophobic ligands (Molecular Pharmacology (2003) 64 (32-41)) Molecular Pharmacology. 64. DOI: 10.1124/Mol.64.5.1270 |
0.759 |
|
| 2001 |
El Kouhen R, Burd AL, Erickson-Herbrandson LJ, Chang CY, Law PY, Loh HH. Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization. The Journal of Biological Chemistry. 276: 12774-80. PMID 11278523 DOI: 10.1074/Jbc.M009571200 |
0.633 |
|
| 2000 |
Kouhen OM, Wang G, Solberg J, Erickson LJ, Law PY, Loh HH. Hierarchical phosphorylation of delta-opioid receptor regulates agonist-induced receptor desensitization and internalization. The Journal of Biological Chemistry. 275: 36659-64. PMID 10973976 DOI: 10.1074/Jbc.M006788200 |
0.591 |
|
| 2000 |
Law PY, Erickson LJ, El-Kouhen R, Dicker L, Solberg J, Wang W, Miller E, Burd AL, Loh HH. Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor. Molecular Pharmacology. 58: 388-98. PMID 10908307 DOI: 10.1124/Mol.58.2.388 |
0.642 |
|
| 2000 |
Law PY, Kouhen OM, Solberg J, Wang W, Erickson LJ, Loh HH. Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor. The Journal of Biological Chemistry. 275: 32057-65. PMID 10893226 DOI: 10.1074/Jbc.M002395200 |
0.639 |
|
| 2000 |
Law PY, Tine SJ, McLeod LA, Loh HH. Association of a lower molecular weight protein to the mu-opioid receptor demonstrated by (125)I-beta-endorphin cross-linking studies. Journal of Neurochemistry. 75: 164-73. PMID 10854259 DOI: 10.1046/J.1471-4159.2000.0750164.X |
0.534 |
|
| 2000 |
Law PY, Wong YH, Loh HH. Molecular mechanisms and regulation of opioid receptor signaling. Annual Review of Pharmacology and Toxicology. 40: 389-430. PMID 10836142 DOI: 10.1146/Annurev.Pharmtox.40.1.389 |
0.548 |
|
| 1999 |
Law PY, Wong YH, Loh HH. Mutational analysis of the structure and function of opioid receptors. Biopolymers. 51: 440-55. PMID 10797232 DOI: 10.1002/(Sici)1097-0282(1999)51:6<440::Aid-Bip6>3.0.Co;2-T |
0.611 |
|
| 1999 |
Ko JL, Arvidsson U, Williams FG, Law PY, Elde R, Loh HH. Visualization of time-dependent redistribution of delta-opioid receptors in neuronal cells during prolonged agonist exposure. Brain Research. Molecular Brain Research. 69: 171-85. PMID 10366739 DOI: 10.1016/S0169-328X(99)00094-7 |
0.505 |
|
| 1999 |
El Kouhen R, Kouhen OM, Law PY, Loh HH. The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. The Journal of Biological Chemistry. 274: 9207-15. PMID 10092593 DOI: 10.1074/Jbc.274.14.9207 |
0.617 |
|
| 1999 |
Gupta K, Kshirsagar S, Li W, Gui L, Ramakrishnan S, Gupta P, Law P, Hebbel RP. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Experimental Cell Research. 247: 495-504. PMID 10066377 DOI: 10.1006/Excr.1998.4359 |
0.72 |
|
| 1998 |
Burd AL, El-Kouhen R, Erickson LJ, Loh HH, Law PY. Identification of serine 356 and serine 363 as the amino acids involved in etorphine-induced down-regulation of the mu-opioid receptor. The Journal of Biological Chemistry. 273: 34488-95. PMID 9852117 DOI: 10.1074/Jbc.273.51.34488 |
0.648 |
|
| 1998 |
Tao PL, Han KF, Wang SD, Lue WM, Elde R, Law PY, Loh HH. Immunohistochemical evidence of down-regulation of mu-opioid receptor after chronic PL-017 in rats. European Journal of Pharmacology. 344: 137-42. PMID 9600647 DOI: 10.1016/S0014-2999(97)01596-3 |
0.552 |
|
| 1997 |
Spencer RJ, Jin W, Thayer SA, Chakrabarti S, Law PY, Loh HH. Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes. Biochemical Pharmacology. 54: 809-18. PMID 9353135 DOI: 10.1016/S0006-2952(97)00243-8 |
0.581 |
|
| 1997 |
Wotta DR, Birnbaum AK, Wilcox GL, Eide R, Law PY. μ-Opioid receptor regulates CFTR coexpressed in Xenopus oocytes in a cAMP independent manner Molecular Brain Research. 44: 55-65. PMID 9030698 DOI: 10.1016/S0169-328X(96)00189-1 |
0.615 |
|
| 1997 |
Law PY, McGinn TM, Campbell KM, Erickson LE, Loh HH. Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner. Molecular Pharmacology. 51: 152-60. PMID 9016358 DOI: 10.1124/Mol.51.1.152 |
0.642 |
|
| 1997 |
Chakrabarti S, Yang W, Law P, Loh HH. The μ-opioid receptor down-regulates differently from the δ-opioid receptor: Requirement of a high affinity receptor/G protein complex formation Molecular Pharmacology. 52: 105-113. DOI: 10.1124/Mol.52.1.105 |
0.659 |
|
| 1996 |
Zhu J, Xue JC, Law PY, Claude PA, Luo LY, Yin J, Chen C, Liu-Chen LY. The region in the mu opioid receptor conferring selectivity for sufentanil over the delta receptor is different from that over the kappa receptor. Febs Letters. 384: 198-202. PMID 8612823 DOI: 10.1016/0014-5793(96)00312-2 |
0.618 |
|
| 1995 |
Chakrabarti S, Law PY, Loh HH. Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine. Brain Research. Molecular Brain Research. 30: 269-78. PMID 7637578 DOI: 10.1016/0169-328X(95)00014-J |
0.629 |
|
| 1993 |
Tao PL, Chang LR, Chou YP, Law PY, Loh HH. Chronic opioid treatment may uncouple opioid receptors and G-proteins: evidence from radiation inactivation analysis. European Journal of Pharmacology. 246: 233-8. PMID 8223946 DOI: 10.1016/0922-4106(93)90036-9 |
0.6 |
|
| 1988 |
Louie AK, Zhan JN, Law PY, Loh HH. Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells. Biochemical and Biophysical Research Communications. 152: 1369-75. PMID 2837185 DOI: 10.1016/S0006-291X(88)80436-4 |
0.622 |
|
| 1986 |
Griffin MT, Law PY, Loh HH. Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells. Journal of Neurochemistry. 47: 1098-105. PMID 3018158 DOI: 10.1111/J.1471-4159.1986.Tb00726.X |
0.389 |
|
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