Peter Hegemann, PhD - Publications

Affiliations: 
Experimental Biophysics Humboldt-Universität zu Berlin, Berlin, Germany 
Area:
microbial opsins

222 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rozenberg A, Kaczmarczyk I, Matzov D, Vierock J, Nagata T, Sugiura M, Katayama K, Kawasaki Y, Konno M, Nagasaka Y, Aoyama M, Das I, Pahima E, Church J, Adam S, ... ... Hegemann P, et al. Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels. Nature Structural & Molecular Biology. 29: 592-603. PMID 35710843 DOI: 10.1038/s41594-022-00783-x  0.79
2021 Penzkofer A, Silapetere A, Hegemann P. Photocycle dynamics of the Archaerhodopsin 3 based fluorescent voltage sensor Archon2. Journal of Photochemistry and Photobiology. B, Biology. 225: 112331. PMID 34688164 DOI: 10.1016/j.jphotobiol.2021.112331  0.33
2021 Sizova I, Kelterborn S, Verbenko V, Kateriya S, Hegemann P. Chlamydomonas POLQ is necessary for CRISPR/Cas9-mediated gene targeting. G3 (Bethesda, Md.). PMID 33836052 DOI: 10.1093/g3journal/jkab114  0.627
2021 Oda K, Nomura T, Nakane T, Yamashita K, Inoue K, Ito S, Vierock J, Hirata K, Maturana AD, Katayama K, Ikuta T, Ishigami I, Izume T, Umeda R, Eguma R, ... ... Hegemann P, et al. Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin. Elife. 10. PMID 33752801 DOI: 10.7554/eLife.62389  0.324
2021 Henß T, Nagpal J, Gao S, Scheib U, Pieragnolo A, Hirschhäuser A, Schneider-Warme F, Hegemann P, Nagel G, Gottschalk A. Optogenetic tools for manipulation of cyclic nucleotides, functionally coupled to CNG-channels. British Journal of Pharmacology. PMID 33733470 DOI: 10.1111/bph.15445  0.79
2020 Broser M, Spreen A, Konold PE, Peter E, Adam S, Borin V, Schapiro I, Seifert R, Kennis JTM, Bernal Sierra YA, Hegemann P. NeoR, a near-infrared absorbing rhodopsin. Nature Communications. 11: 5682. PMID 33173168 DOI: 10.1038/s41467-020-19375-8  0.333
2020 Rozenberg A, Oppermann J, Wietek J, Fernandez Lahore RG, Sandaa RA, Bratbak G, Hegemann P, Béjà O. Lateral Gene Transfer of Anion-Conducting Channelrhodopsins between Green Algae and Giant Viruses. Current Biology : Cb. PMID 33065010 DOI: 10.1016/j.cub.2020.09.056  0.786
2020 Kaufmann JCD, Krause BS, Adam S, Ritter E, Schapiro I, Hegemann P, Bartl FJ. Modulation of Light Energy Transfer from Chromophore to Protein in the Channelrhodopsin ReaChR. Biophysical Journal. PMID 32697975 DOI: 10.1016/J.Bpj.2020.06.031  0.33
2020 Hontani Y, Broser M, Luck M, Weissenborn J, Kloz M, Hegemann P, Kennis JTM. Dual photoisomerization on distinct potential energy surfaces in a UV absorbing rhodopsin. Journal of the American Chemical Society. PMID 32475117 DOI: 10.1021/Jacs.0C03229  0.375
2019 Penzkofer A, Silapetere A, Hegemann P. Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1. International Journal of Molecular Sciences. 21. PMID 31881701 DOI: 10.3390/Ijms21010160  0.386
2019 Ritter E, Puskar L, Kim SY, Park JH, Hofmann KP, Bartl FJ, Hegemann P, Schade U. Féry IR Spectrometer for Single-Shot Analysis of Protein Dynamics. The Journal of Physical Chemistry Letters. PMID 31763851 DOI: 10.1021/Acs.Jpclett.9B03099  0.343
2019 Penzkofer A, Silapetere A, Hegemann P. Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1. International Journal of Molecular Sciences. 20. PMID 31438573 DOI: 10.3390/Ijms20174086  0.321
2019 Oppermann J, Fischer P, Silapetere A, Liepe B, Rodriguez-Rozada S, Flores-Uribe J, Peter E, Keidel A, Vierock J, Kaufmann J, Broser M, Luck M, Bartl F, Hildebrandt P, Simon Wiegert J, ... ... Hegemann P, et al. MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins. Nature Communications. 10: 3315. PMID 31346176 DOI: 10.1038/S41467-019-11322-6  0.804
2019 Vogt A, Silapetere A, Grimm C, Heiser F, Ancina Möller M, Hegemann P. Engineered Passive Potassium Conductance in the KR2 Sodium Pump. Biophysical Journal. PMID 31036257 DOI: 10.1016/J.Bpj.2019.04.001  0.402
2019 Kuhne J, Vierock J, Tennigkeit SA, Dreier MA, Wietek J, Petersen D, Gavriljuk K, El-Mashtoly SF, Hegemann P, Gerwert K. Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31004059 DOI: 10.1073/Pnas.1818707116  0.805
2019 Mukherjee S, Hegemann P, Broser M. Enzymerhodopsins: novel photoregulated catalysts for optogenetics. Current Opinion in Structural Biology. 57: 118-126. PMID 30954887 DOI: 10.1016/J.Sbi.2019.02.003  0.394
2019 Giliberti V, Polito R, Ritter E, Broser M, Hegemann P, Puskar L, Schade U, Zanetti-Polzi L, Daidone I, Corni S, Rusconi F, Biagioni P, Baldassarre L, Ortolani M. Tip-enhanced Infrared Difference-Nanospectroscopy of the Proton Pump Activity of Bacteriorhodopsin in Single Purple Membrane Patches. Nano Letters. PMID 30950626 DOI: 10.1021/Acs.Nanolett.9B00512  0.388
2019 Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P. Design of a light-gated proton channel based on the crystal structure of rhodopsin. Science Signaling. 12. PMID 30890657 DOI: 10.1126/Scisignal.Aav4203  0.443
2019 Böhm M, Boness D, Fantisch E, Erhard H, Frauenholz J, Kowalzyk Z, Marcinkowski N, Kateriya S, Hegemann P, Kreimer G. Channelrhodopsin-1 phosphorylation changes with the phototactic behavior and responds to physiological stimuli in Chlamydomonas. The Plant Cell. PMID 30862615 DOI: 10.1105/Tpc.18.00936  0.722
2019 Luck M, Velázquez Escobar F, Glass K, Sabotke MI, Hagedorn R, Corellou F, Siebert F, Hildebrandt P, Hegemann P. Photoreactions of the histidine kinase rhodopsin Ot-HKR from the marine picoalga Ostreococcus tauri. Biochemistry. PMID 30768260 DOI: 10.1021/Acs.Biochem.8B01200  0.464
2019 Krause BS, Kaufmann JCD, Kuhne J, Vierock J, Huber T, Sakmar TP, Gerwert K, Bartl F, Hegemann P. Tracking pore hydration in channelrhodopsin by site-directed infrared-active azido probes. Biochemistry. PMID 30702875 DOI: 10.1021/Acs.Biochem.8B01211  0.408
2018 Bernal Sierra YA, Rost BR, Pofahl M, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, ... Hegemann P, et al. Potassium channel-based optogenetic silencing. Nature Communications. 9: 4611. PMID 30397200 DOI: 10.1038/S41467-018-07038-8  0.825
2018 Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T, Hegemann P, Nureki O. Crystal structure of the red light-activated channelrhodopsin Chrimson. Nature Communications. 9: 3949. PMID 30258177 DOI: 10.2210/Pdb5Zih/Pdb  0.494
2018 Grimm C, Silapetere A, Vogt A, Bernal Sierra YA, Hegemann P. Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2. Scientific Reports. 8: 9316. PMID 29915394 DOI: 10.1038/S41598-018-27690-W  0.435
2018 Scheib U, Broser M, Constantin OM, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee CE, Hegemann P. Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain. Nature Communications. 9: 2046. PMID 29799525 DOI: 10.1038/S41467-018-04428-W  0.672
2018 Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS. Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Scientific Reports. 8: 4765. PMID 29540835 DOI: 10.1038/S41598-018-23001-5  0.761
2018 Andrea Bernal Sierra Y, Rost B, Oldani S, Schneider-Warme F, Seifert R, Schmitz D, Hegemann P. Potassium Channel-Based Two Component Optogenetic Tool for Silencing of Excitable Cells Biophysical Journal. 114: 668a. DOI: 10.1016/J.Bpj.2017.11.3607  0.788
2018 Vogt A, Grimm C, Silapetere A, Bernal Sierra YA, Hegemann P. Electrophysiology of the engineered light-driven sodium pump eKR2 and its conversion into a channel Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e28. DOI: 10.1016/J.Bbabio.2018.09.086  0.412
2017 Hontani Y, Broser M, Silapetere A, Krause BS, Hegemann P, Kennis JTM. The femtosecond-to-second photochemistry of red-shifted fast-closing anion channelrhodopsin PsACR1. Physical Chemistry Chemical Physics : Pccp. PMID 29125160 DOI: 10.1039/C7Cp06414D  0.383
2017 Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS. Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Scientific Reports. 7: 14957. PMID 29097684 DOI: 10.1038/S41598-017-14330-Y  0.842
2017 Rost BR, Schneider-Warme F, Schmitz D, Hegemann P. Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron. 96: 572-603. PMID 29096074 DOI: 10.1016/J.Neuron.2017.09.047  0.78
2017 Penzkofer A, Scheib U, Stehfest K, Hegemann P. Absorption and Emission Spectroscopic Investigation of Thermal Dynamics and Photo-Dynamics of the Rhodopsin Domain of the Rhodopsin-Guanylyl Cyclase from the Nematophagous Fungus Catenaria anguillulae. International Journal of Molecular Sciences. 18. PMID 28981475 DOI: 10.3390/Ijms18102099  0.39
2017 Greiner A, Kelterborn S, Evers H, Kreimer G, Sizova I, Hegemann P. Targeting of Photoreceptor Genes in Chlamydomonas reinhardtii via Zinc-finger Nucleases and CRISPR/Cas9. The Plant Cell. PMID 28978758 DOI: 10.1105/Tpc.17.00659  0.305
2017 Giliberti V, Badioli M, Nucara A, Calvani P, Ritter E, Puskar L, Aziz EF, Hegemann P, Schade U, Ortolani M, Baldassarre L. Heterogeneity of the Transmembrane Protein Conformation in Purple Membranes Identified by Infrared Nanospectroscopy. Small (Weinheim An Der Bergstrasse, Germany). PMID 28960799 DOI: 10.1002/Smll.201701181  0.308
2017 Deisseroth K, Hegemann P. The form and function of channelrhodopsin. Science (New York, N.Y.). 357. PMID 28912215 DOI: 10.1126/Science.Aan5544  0.601
2017 Vierock J, Grimm C, Nitzan N, Hegemann P. Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson. Scientific Reports. 7: 9928. PMID 28855540 DOI: 10.1038/S41598-017-09600-8  0.478
2017 Luck M, Hegemann P. The two parallel photocycles of the Chlamydomonas sensory photoreceptor histidine kinase rhodopsin 1. Journal of Plant Physiology. PMID 28784569 DOI: 10.1016/J.Jplph.2017.07.008  0.415
2017 Hontani Y, Marazzi M, Stehfest K, Mathes T, van Stokkum IHM, Elstner M, Hegemann P, Kennis JTM. Reaction dynamics of the chimeric channelrhodopsin C1C2. Scientific Reports. 7: 7217. PMID 28775289 DOI: 10.1038/S41598-017-07363-W  0.68
2017 Kaufmann JCD, Krause BS, Grimm C, Ritter E, Hegemann P, Bartl FJ. Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function. The Journal of Biological Chemistry. PMID 28659342 DOI: 10.1074/Jbc.M117.779629  0.409
2017 Grimm C, Vierock J, Hegemann P, Wietek J. Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins. Journal of Visualized Experiments : Jove. PMID 28570519 DOI: 10.3791/55497  0.78
2017 Krause BS, Grimm C, Kaufmann JC, Schneider F, Sakmar TP, Bartl FJ, Hegemann P. Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR. Biophysical Journal. 112: 1166-1175. PMID 28355544 DOI: 10.1016/J.Bpj.2017.02.001  0.393
2017 Wietek J, Wiegert JS, Grimm C, Soba P, Hegemann P. Artificial Anion Conducting Channelrhodopsins with Tuned Spectra, Modified Kinetics and Enhanced Light Sensitivity Biophysical Journal. 112: 172a. DOI: 10.1016/J.Bpj.2016.11.952  0.815
2017 Gasser CF, Hegemann P. Light-Activated Cyclic Nucleotide Phosphodiesterases Biophysical Journal. 112: 172a. DOI: 10.1016/J.Bpj.2016.11.950  0.449
2017 Scheib U, Stehfest K, Gee CE, Körschen HG, Mukherjee S, Oertner TG, Hegemann P. Optical Control of cGMP Signaling Biophysical Journal. 112: 90a. DOI: 10.1016/J.Bpj.2016.11.527  0.692
2017 Vierock J, Nitzan N, Hegemann P. Molecular Determinants of Photocurrent Kinetics of the Red Light Activable Channelrhodopsin Chrimson Biophysical Journal. 112: 550a. DOI: 10.1016/J.Bpj.2016.11.2970  0.491
2017 Kopton R, Rog-Zielinska E, Siedlecka U, Wietek J, Hegemann P, Kohl P, Schneider F. Optogenetic Modulation of Cardiomyocyte Excitability Biophysical Journal. 112: 424a. DOI: 10.1016/J.Bpj.2016.11.2268  0.783
2016 Guo Y, Beyle FE, Bold BM, Watanabe HC, Koslowski A, Thiel W, Hegemann P, Marazzi M, Elstner M. Active site structure and absorption spectrum of channelrhodopsin-2 wild-type and C128T mutant. Chemical Science. 7: 3879-3891. PMID 30155032 DOI: 10.1039/C6Sc00468G  0.303
2016 Takahashi N, Oertner TG, Hegemann P, Larkum ME. Active cortical dendrites modulate perception. Science (New York, N.Y.). 354: 1587-1590. PMID 28008068 DOI: 10.1126/Science.Aah6066  0.622
2016 Zhu J, Mathes T, Hontani Y, Alexandre MT, Toh KC, Hegemann P, Kennis JT. Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Chlamydomonas Reinhardtii Phototropin. The Journal of Physical Chemistry Letters. PMID 27766868 DOI: 10.1021/Acs.Jpclett.6B02075  0.729
2016 Petroutsos D, Tokutsu R, Maruyama S, Flori S, Greiner A, Magneschi L, Cusant L, Kottke T, Mittag M, Hegemann P, Finazzi G, Minagawa J. A blue-light photoreceptor mediates the feedback regulation of photosynthesis. Nature. PMID 27626383 DOI: 10.1038/Nature19358  0.457
2016 Konold PE, Mathes T, Weissenborn J, Groot ML, Hegemann P, Kennis JT. Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy. The Journal of Physical Chemistry Letters. PMID 27537211 DOI: 10.1021/Acs.Jpclett.6B01484  0.721
2016 Ferenczi EA, Vierock J, Atsuta-Tsunoda K, Tsunoda SP, Ramakrishnan C, Gorini C, Thompson K, Lee SY, Berndt A, Perry C, Minniberger S, Vogt A, Mattis J, Prakash R, Delp S, ... ... Hegemann P, et al. Optogenetic approaches addressing extracellular modulation of neural excitability. Scientific Reports. 6: 23947. PMID 27045897 DOI: 10.1038/Srep23947  0.811
2016 Wietek J, Broser M, Krause BS, Hegemann P. Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin from Proteomonas sulcata. The Journal of Biological Chemistry. PMID 26740624 DOI: 10.1074/Jbc.M115.699637  0.808
2016 Penzkofer A, Kateriya S, Hegemann P. Photodynamics of the optogenetic BLUF coupled photoactivated adenylyl cyclases (PACs) Dyes and Pigments. 135: 102-112. DOI: 10.1016/J.Dyepig.2016.05.037  0.679
2016 Vogt A, Grimm C, Hegemann P. The Diversity of Light-Driven Ion Pumps and their Conversion into Ion Channels Biophysical Journal. 110: 630a. DOI: 10.1016/J.Bpj.2015.11.3374  0.448
2015 Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, ... ... Hegemann P, et al. Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699459 DOI: 10.1073/Pnas.1523341113  0.818
2015 Mehlhorn J, Lindtner T, Richter F, Glaß K, Steinocher H, Beck S, Hegemann P, Kennis JT, Mathes T. Light-Induced Rearrangement of the β5 Strand in the BLUF Photoreceptor SyPixD (Slr1694). The Journal of Physical Chemistry Letters. 6: 4749-53. PMID 26631358 DOI: 10.1021/Acs.Jpclett.5B02245  0.706
2015 Vogt A, Guo Y, Tsunoda SP, Kateriya S, Elstner M, Hegemann P. Conversion of a light-driven proton pump into a light-gated ion channel. Scientific Reports. 5: 16450. PMID 26597707 DOI: 10.1038/Srep16450  0.809
2015 Rost BR, Schneider F, Grauel MK, Wozny C, G Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C. Optogenetic acidification of synaptic vesicles and lysosomes. Nature Neuroscience. PMID 26551543 DOI: 10.1038/Nn.4161  0.761
2015 Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Simon Wiegert J. An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Scientific Reports. 5: 14807. PMID 26443033 DOI: 10.1038/Srep14807  0.82
2015 Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, et al. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nature Neuroscience. 18: 1202-12. PMID 26308981 DOI: 10.1038/Nn.4106  0.666
2015 Scheib U, Stehfest K, Gee CE, Körschen HG, Fudim R, Oertner TG, Hegemann P. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Science Signaling. 8: rs8. PMID 26268609 DOI: 10.1126/Scisignal.Aab0611  0.718
2015 Bruun S, Stoeppler D, Keidel A, Kuhlmann U, Luck M, Diehl A, Geiger MA, Woodmansee D, Trauner D, Hegemann P, Oschkinat H, Hildebrandt P, Stehfest K. Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers. Biochemistry. 54: 5389-400. PMID 26237332 DOI: 10.1021/Acs.Biochem.5B00597  0.457
2015 Ritter E, Puskar L, Bartl FJ, Aziz EF, Hegemann P, Schade U. Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin. Frontiers in Molecular Biosciences. 2: 38. PMID 26217670 DOI: 10.3389/Fmolb.2015.00038  0.451
2015 Schneider F, Grimm C, Hegemann P. Biophysics of Channelrhodopsin. Annual Review of Biophysics. 44: 167-86. PMID 26098512 DOI: 10.1146/Annurev-Biophys-060414-034014  0.47
2015 Luck M, Bruun S, Keidel A, Hegemann P, Hildebrandt P. Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1. Febs Letters. 589: 1067-71. PMID 25836735 DOI: 10.1016/J.Febslet.2015.03.024  0.365
2015 AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF. Erratum: Synthetic retinal analogs modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications. 6: 6458. PMID 25711720 DOI: 10.1038/Ncomms7458  0.537
2015 Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D. Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife. 4. PMID 25601414 DOI: 10.7554/Elife.05161  0.38
2015 Kuhne J, Eisenhauer K, Ritter E, Hegemann P, Gerwert K, Bartl F. Early formation of the ion-conducting pore in channelrhodopsin-2. Angewandte Chemie (International Ed. in English). 54: 4953-7. PMID 25537168 DOI: 10.1002/Anie.201410180  0.423
2015 Richter F, Scheib US, Mehlhorn J, Schubert R, Wietek J, Gernetzki O, Hegemann P, Mathes T, Möglich A. Upgrading a microplate reader for photobiology and all-optical experiments. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 14: 270-9. PMID 25373866 DOI: 10.1039/C4Pp00361F  0.826
2014 AzimiHashemi N, Erbguth K, Vogt A, Riemensperger T, Rauch E, Woodmansee D, Nagpal J, Brauner M, Sheves M, Fiala A, Kattner L, Trauner D, Hegemann P, Gottschalk A, Liewald JF. Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools. Nature Communications. 5: 5810. PMID 25503804 DOI: 10.1038/Ncomms6810  0.61
2014 Penzkofer A, Stierl M, Mathes T, Hegemann P. Absorption and emission spectroscopic characterization of photo-dynamics of photoactivated adenylyl cyclase mutant bPAC-Y7F of Beggiatoa sp. Journal of Photochemistry and Photobiology. B, Biology. 140: 182-93. PMID 25154810 DOI: 10.1016/J.Jphotobiol.2014.06.017  0.71
2014 Stierl M, Penzkofer A, Kennis JT, Hegemann P, Mathes T. Key residues for the light regulation of the blue light-activated adenylyl cyclase from Beggiatoa sp. Biochemistry. 53: 5121-30. PMID 25046330 DOI: 10.1021/Bi500479V  0.731
2014 Gasser C, Taiber S, Yeh CM, Wittig CH, Hegemann P, Ryu S, Wunder F, Möglich A. Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 111: 8803-8. PMID 24889611 DOI: 10.1073/Pnas.1321600111  0.459
2014 Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P. Conversion of channelrhodopsin into a light-gated chloride channel. Science (New York, N.Y.). 344: 409-12. PMID 24674867 DOI: 10.1126/Science.1249375  0.83
2014 Penzkofer A, Luck M, Mathes T, Hegemann P. Bistable retinal schiff base photodynamics of histidine kinase rhodopsin HKR1 from Chlamydomonas reinhardtii. Photochemistry and Photobiology. 90: 773-85. PMID 24460585 DOI: 10.1111/Php.12246  0.714
2014 Ernst OP, Lodowski DT, Elstner M, Hegemann P, Brown LS, Kandori H. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. Chemical Reviews. 114: 126-63. PMID 24364740 DOI: 10.1021/Cr4003769  0.394
2014 Grote M, Engelhard M, Hegemann P. Of ion pumps, sensors and channels - perspectives on microbial rhodopsins between science and history. Biochimica Et Biophysica Acta. 1837: 533-45. PMID 23994288 DOI: 10.1016/J.Bbabio.2013.08.006  0.407
2014 Penzkofer A, Luck M, Mathes T, Hegemann P. Ultrafast Laser Energy Density and Retinal Absorption Cross-Section Determination by Saturable Absorption Measurements Journal of Analytical Sciences, Methods and Instrumentation. 4: 19-26. DOI: 10.4236/Jasmi.2014.41003  0.662
2014 Penzkofer A, Tanwar M, Veetil SK, Kateriya S, Stierl M, Hegemann P. Photo-dynamics of BLUF domain containing adenylyl cyclase NgPAC3 from the amoeboflagellate Naegleria gruberi NEG-M strain Journal of Photochemistry and Photobiology a: Chemistry. 287: 19-29. DOI: 10.1016/J.Jphotochem.2014.04.017  0.697
2014 Schneider F, Rost B, Rosenmund C, Hegemann P. New Concepts for Presynaptic Optogenetics Biophysical Journal. 106: 383a. DOI: 10.1016/J.Bpj.2013.11.2165  0.758
2014 Krause BS, Hegemann P, Huber T, Sakmar TP. Site-Specific Tagging of Channelrhodopsins with Genetically-Encoded Azido Groups Biophysical Journal. 106: 381a. DOI: 10.1016/J.Bpj.2013.11.2155  0.417
2014 Vogt A, Wietek J, Hegemann P. Limitation of Light Driven Proton Pumps at High Electrochemical Load Biophysical Journal. 106: 369a. DOI: 10.1016/J.Bpj.2013.11.2090  0.784
2013 Mehlhorn J, Steinocher H, Beck S, Kennis JT, Hegemann P, Mathes T. A set of engineered Escherichia coli expression strains for selective isotope and reactivity labeling of amino acid side chains and flavin cofactors. Plos One. 8: e79006. PMID 24223875 DOI: 10.1371/Journal.Pone.0079006  0.682
2013 Vogt A, Wietek J, Hegemann P. Gloeobacter rhodopsin, limitation of proton pumping at high electrochemical load. Biophysical Journal. 105: 2055-63. PMID 24209850 DOI: 10.1016/J.Bpj.2013.08.031  0.779
2013 Möglich A, Hegemann P. Biotechnology: Programming genomes with light. Nature. 500: 406-8. PMID 23969454 DOI: 10.1038/500406A  0.404
2013 Schneider F, Gradmann D, Hegemann P. Ion selectivity and competition in channelrhodopsins. Biophysical Journal. 105: 91-100. PMID 23823227 DOI: 10.1016/J.Bpj.2013.05.042  0.42
2013 Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, ... ... Hegemann P, et al. Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Frontiers in Molecular Neuroscience. 6: 2. PMID 23459413 DOI: 10.3389/Fnmol.2013.00002  0.759
2013 Ritter E, Piwowarski P, Hegemann P, Bartl FJ. Light-dark adaptation of channelrhodopsin C128T mutant. The Journal of Biological Chemistry. 288: 10451-8. PMID 23439646 DOI: 10.1074/Jbc.M112.446427  0.437
2013 Watanabe HC, Welke K, Sindhikara DJ, Hegemann P, Elstner M. Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism. Journal of Molecular Biology. 425: 1795-814. PMID 23376098 DOI: 10.1016/J.Jmb.2013.01.033  0.382
2013 Hegemann P, Nagel G. From channelrhodopsins to optogenetics. Embo Molecular Medicine. 5: 173-6. PMID 23339069 DOI: 10.1002/Emmm.201202387  0.607
2013 Sizova I, Greiner A, Awasthi M, Kateriya S, Hegemann P. Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases. The Plant Journal : For Cell and Molecular Biology. 73: 873-82. PMID 23137232 DOI: 10.1111/Tpj.12066  0.674
2013 Penzkofer A, Tanwar M, Veetil SK, Kateriya S, Stierl M, Hegemann P. Photo-dynamics of the lyophilized photo-activated adenylate cyclase NgPAC2 from the amoeboflagellate Naegleria gruberi NEG-M strain Chemical Physics. 423: 192-201. DOI: 10.1016/J.Chemphys.2013.07.001  0.723
2013 Penzkofer A, Tanwar M, Veetil SK, Kateriya S, Stierl M, Hegemann P. Photo-dynamics and thermal behavior of the BLUF domain containing adenylate cyclase NgPAC2 from the amoeboflagellate Naegleria gruberi NEG-M strain Chemical Physics. 412: 96-108. DOI: 10.1016/J.Chemphys.2012.12.015  0.701
2012 Trippens J, Greiner A, Schellwat J, Neukam M, Rottmann T, Lu Y, Kateriya S, Hegemann P, Kreimer G. Phototropin influence on eyespot development and regulation of phototactic behavior in Chlamydomonas reinhardtii. The Plant Cell. 24: 4687-702. PMID 23204408 DOI: 10.1105/Tpc.112.103523  0.735
2012 Erbguth K, Prigge M, Schneider F, Hegemann P, Gottschalk A. Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans. Plos One. 7: e46827. PMID 23056472 DOI: 10.1371/Journal.Pone.0046827  0.783
2012 Luck M, Mathes T, Bruun S, Fudim R, Hagedorn R, Tran Nguyen TM, Kateriya S, Kennis JT, Hildebrandt P, Hegemann P. A photochromic histidine kinase rhodopsin (HKR1) that is bimodally switched by ultraviolet and blue light. The Journal of Biological Chemistry. 287: 40083-90. PMID 23027869 DOI: 10.1074/Jbc.M112.401604  0.84
2012 Prigge M, Schneider F, Tsunoda SP, Shilyansky C, Wietek J, Deisseroth K, Hegemann P. Color-tuned channelrhodopsins for multiwavelength optogenetics. The Journal of Biological Chemistry. 287: 31804-12. PMID 22843694 DOI: 10.1074/Jbc.M112.391185  0.822
2012 Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O. Crystal structure of the channelrhodopsin light-gated cation channel. Nature. 482: 369-74. PMID 22266941 DOI: 10.1038/Nature10870  0.745
2012 Watanabe HC, Welke K, Schneider F, Tsunoda S, Zhang F, Deisseroth K, Hegemann P, Elstner M. Structural model of channelrhodopsin. The Journal of Biological Chemistry. 287: 7456-66. PMID 22241469 DOI: 10.1074/Jbc.M111.320309  0.738
2012 Eisenhauer K, Kuhne J, Ritter E, Berndt A, Wolf S, Freier E, Bartl F, Hegemann P, Gerwert K. In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle. The Journal of Biological Chemistry. 287: 6904-11. PMID 22219197 DOI: 10.1074/Jbc.M111.327700  0.763
2012 Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O. 1PT128 Crystal Structure of a light-gated cation channel, channeirhodopsin(The 50th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 52: S90. DOI: 10.2142/Biophys.52.S90_3  0.716
2012 Mathes T, Zhu J, Van Stokkum IHM, Groot ML, Hegemann P, Kennis JTM. Hydrogen bond switching among flavin and amino acids determines the nature of proton-coupled electron transfer in bluf photoreceptors Journal of Physical Chemistry Letters. 3: 203-208. DOI: 10.1021/Jz201579Y  0.704
2012 Penzkofer A, Stierl M, Hegemann P, Kateriya S. Absorption and fluorescence characteristics of photo-activated adenylate cyclase nano-clusters from the amoeboflagellate Naegleria gruberi NEG-M strain Chemical Physics. 392: 46-54. DOI: 10.1016/J.Chemphys.2011.09.005  0.674
2012 Schneider F, Prigge M, Tsunoda SP, Yizhar O, Deisseroth K, Hegemann P. Yellow Optogenetics with Volvox Channelrhodopsin Variants Biophysical Journal. 102: 681a-682a. DOI: 10.1016/J.Bpj.2011.11.3705  0.831
2012 Ritter E, Stehfest K, Piwowarski P, Berndt A, Kazmin R, Hegemann P, Bartl FJ. Intermediates of the Channel Rhodopsin Photocycle Biophysical Journal. 102: 516a-517a. DOI: 10.1016/J.Bpj.2011.11.2826  0.753
2012 Hegemann P, Gradmann D, Schneider F. Channelrhodopsin: Ideas about Gating and Ion Transport Biophysical Journal. 102: 41a. DOI: 10.1016/J.Bpj.2011.11.252  0.389
2011 Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A, Cushman J, Polle J, Magnuson J, Hegemann P, Deisseroth K. The microbial opsin family of optogenetic tools. Cell. 147: 1446-57. PMID 22196724 DOI: 10.1016/J.Cell.2011.12.004  0.794
2011 Bruun S, Naumann H, Kuhlmann U, Schulz C, Stehfest K, Hegemann P, Hildebrandt P. The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant. Febs Letters. 585: 3998-4001. PMID 22094167 DOI: 10.1016/J.Febslet.2011.11.007  0.325
2011 Welke K, Frähmcke JS, Watanabe HC, Hegemann P, Elstner M. Color tuning in binding pocket models of the chlamydomonas-type channelrhodopsins. The Journal of Physical Chemistry. B. 115: 15119-28. PMID 22077286 DOI: 10.1021/Jp2085457  0.314
2011 Gradmann D, Berndt A, Schneider F, Hegemann P. Rectification of the channelrhodopsin early conductance. Biophysical Journal. 101: 1057-68. PMID 21889442 DOI: 10.1016/J.Bpj.2011.07.040  0.73
2011 Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 477: 171-8. PMID 21796121 DOI: 10.1038/Nature10360  0.764
2011 Mathes T, van Stokkum IH, Bonetti C, Hegemann P, Kennis JT. The hydrogen-bond switch reaction of the Blrb Bluf domain of Rhodobacter sphaeroides. The Journal of Physical Chemistry. B. 115: 7963-71. PMID 21627064 DOI: 10.1021/Jp201296M  0.72
2011 Gärtner W, Hegemann P. Introduction to the Symposium-in Print: Blue light effects. Photochemistry and Photobiology. 87: 489-90. PMID 21517885 DOI: 10.1111/J.1751-1097.2011.00926.X  0.417
2011 Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proceedings of the National Academy of Sciences of the United States of America. 108: 7595-600. PMID 21504945 DOI: 10.1073/Pnas.1017210108  0.823
2011 Yizhar O, Fenno L, Zhang F, Hegemann P, Diesseroth K. Microbial opsins: a family of single-component tools for optical control of neural activity. Cold Spring Harbor Protocols. 2011: top102. PMID 21363959 DOI: 10.1101/Pdb.Top102  0.636
2011 Weber S, Schroeder C, Kacprzak S, Mathes T, Kowalczyk RM, Essen LO, Hegemann P, Schleicher E, Bittl R. Light-generated paramagnetic intermediates in BLUF domains. Photochemistry and Photobiology. 87: 574-83. PMID 21198648 DOI: 10.1111/J.1751-1097.2010.00885.X  0.712
2011 Stierl M, Stumpf P, Udwari D, Gueta R, Hagedorn R, Losi A, Gärtner W, Petereit L, Efetova M, Schwarzel M, Oertner TG, Nagel G, Hegemann P. Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. The Journal of Biological Chemistry. 286: 1181-8. PMID 21030594 DOI: 10.1074/Jbc.M110.185496  0.809
2011 Tyagi A, Penzkofer A, Mathes T, Hegemann P. Photo-cycle dynamics of LOV1-His domain of phototropin from chlamydomonas reinhardtii with roseoflavin monophosphate cofactor Proceedings of Spie - the International Society For Optical Engineering. 7993. DOI: 10.1117/12.879134  0.634
2011 Tsunoda S, Prigge M, Schneider F, Hegemann P. Multicolor optogenetics Neuroscience Research. 71: e313. DOI: 10.1016/j.neures.2011.07.1364  0.616
2011 Tsunoda K, Tsunoda S, Hegemann P. Engineering photoswitchable ion channel Neuroscience Research. 71: e312-e313. DOI: 10.1016/J.Neures.2011.07.1363  0.642
2011 Hegemann P, Prigge M, Schneider F, Stierl M. Channelrhodopsin variants and new microbial photoreceptors for optogenetic application Neuroscience Research. 71: e24. DOI: 10.1016/J.Neures.2011.07.101  0.727
2011 Penzkofer A, Stierl M, Hegemann P, Kateriya S. Thermal protein unfolding in photo-activated adenylate cyclase nano-clusters from the amoeboflagellate Naegleria gruberi NEG-M strain Journal of Photochemistry and Photobiology a: Chemistry. 225: 42-51. DOI: 10.1016/J.Jphotochem.2011.09.024  0.676
2011 Penzkofer A, Stierl M, Hegemann P, Kateriya S. Photo-dynamics of the BLUF domain containing soluble adenylate cyclase (nPAC) from the amoeboflagellate Naegleria gruberi NEG-M strain Chemical Physics. 387: 25-38. DOI: 10.1016/J.Chemphys.2011.05.028  0.702
2010 Prigge M, Rösler A, Hegemann P. Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2. Channels (Austin, Tex.). 4: 241-7. PMID 20714225 DOI: 10.4161/Chan.4.3.11888  0.778
2010 Tyagi A, Penzkofer A, Mathes T, Hegemann P. Photophysical characterisation and photo-cycle dynamics of LOV1-His domain of phototropin from Chlamydomonas reinhardtii with roseoflavin monophosphate cofactor. Journal of Photochemistry and Photobiology. B, Biology. 101: 76-88. PMID 20655238 DOI: 10.1016/J.Jphotobiol.2010.06.014  0.738
2010 Brosi R, Illarionov B, Mathes T, Fischer M, Joshi M, Bacher A, Hegemann P, Bittl R, Weber S, Schleicher E. Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction. Journal of the American Chemical Society. 132: 8935-44. PMID 20536240 DOI: 10.1021/Ja910681Z  0.691
2010 Stehfest K, Hegemann P. Evolution of the channelrhodopsin photocycle model. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 11: 1120-6. PMID 20349494 DOI: 10.1002/Cphc.200900980  0.3
2010 Stehfest K, Ritter E, Berndt A, Bartl F, Hegemann P. The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T. Journal of Molecular Biology. 398: 690-702. PMID 20346954 DOI: 10.1016/J.Jmb.2010.03.031  0.766
2010 Berndt A, Prigge M, Gradmann D, Hegemann P. Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle. Biophysical Journal. 98: 753-61. PMID 20197028 DOI: 10.1016/J.Bpj.2009.10.052  0.819
2010 Gunaydin LA, Yizhar O, Berndt A, Sohal VS, Deisseroth K, Hegemann P. Ultrafast optogenetic control. Nature Neuroscience. 13: 387-92. PMID 20081849 DOI: 10.1038/Nn.2495  0.785
2010 Pfeifer A, Mathes T, Lu Y, Hegemann P, Kottke T. Blue light induces global and localized conformational changes in the kinase domain of full-length phototropin. Biochemistry. 49: 1024-32. PMID 20052995 DOI: 10.1021/Bi9016044  0.714
2010 Tyagi A, Penzkofer A, Mathes T, Hegemann P. Photo-degradation behaviour of roseoflavin in some aqueous solutions Chemical Physics. 369: 27-36. DOI: 10.1016/J.Chemphys.2010.02.004  0.679
2010 Prigge M, Schneider F, Tsunoda SS, Hegemann P. Functional Studies of Volvox Channelrhodopsin Chimeras Biophysical Journal. 98: 710a. DOI: 10.1016/J.Bpj.2009.12.3893  0.765
2010 Berndt A, Stehfest K, Gradmann D, Hegemann P. Channelrhodopsin-2 Variants with Accelerated and Decelerated Channel Kinetics Biophysical Journal. 98: 709a. DOI: 10.1016/J.Bpj.2009.12.3888  0.777
2010 Schneider F, Prigge M, Tsunoda S, Hegemann P. Color Shifted Channelrhodopsins- Towards Red Light Optogenetics Biophysical Journal. 98: 538a. DOI: 10.1016/J.Bpj.2009.12.2920  0.835
2009 Bonetti C, Stierl M, Mathes T, van Stokkum IH, Mullen KM, Cohen-Stuart TA, van Grondelle R, Hegemann P, Kennis JT. The role of key amino acids in the photoactivation pathway of the Synechocystis Slr1694 BLUF domain. Biochemistry. 48: 11458-69. PMID 19863128 DOI: 10.1021/Bi901196X  0.725
2009 Zirak P, Penzkofer A, Mathes T, Hegemann P. Absorption and emission spectroscopic characterization of BLUF protein Slr1694 from Synechocystis sp. PCC6803 with roseoflavin cofactor. Journal of Photochemistry and Photobiology. B, Biology. 97: 61-70. PMID 19758819 DOI: 10.1016/J.Jphotobiol.2009.08.002  0.721
2009 Looser J, Schröder-Lang S, Hegemann P, Nagel G. Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha). Biological Chemistry. 390: 1105-11. PMID 19747080 DOI: 10.1515/Bc.2009.132  0.635
2009 Kianianmomeni A, Stehfest K, Nematollahi G, Hegemann P, Hallmann A. Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of light, temperature, and the sex inducer. Plant Physiology. 151: 347-66. PMID 19641026 DOI: 10.1104/Pp.109.143297  0.437
2009 Tsunoda SP, Hegemann P. Glu 87 of channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation. Photochemistry and Photobiology. 85: 564-9. PMID 19192197 DOI: 10.1111/J.1751-1097.2008.00519.X  0.693
2009 Zorin B, Lu Y, Sizova I, Hegemann P. Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene. Gene. 432: 91-6. PMID 19121376 DOI: 10.1016/J.Gene.2008.11.028  0.776
2009 Berndt A, Yizhar O, Gunaydin LA, Hegemann P, Deisseroth K. Bi-stable neural state switches. Nature Neuroscience. 12: 229-34. PMID 19079251 DOI: 10.1038/Nn.2247  0.819
2009 Mathes T, Vogl C, Stolz J, Hegemann P. In vivo generation of flavoproteins with modified cofactors. Journal of Molecular Biology. 385: 1511-8. PMID 19027027 DOI: 10.1016/J.Jmb.2008.11.001  0.734
2009 Tyagi A, Zirak P, Penzkofer A, Mathes T, Hegemann P, Mack M, Ghisla S. Absorption and emission spectroscopic characterisation of 8-amino-riboflavin Chemical Physics. 364: 19-30. DOI: 10.1016/J.Chemphys.2009.08.005  0.694
2009 Zirak P, Penzkofer A, Mathes T, Hegemann P. Photo-dynamics of roseoflavin and riboflavin in aqueous and organic solvents Chemical Physics. 358: 111-122. DOI: 10.1016/J.Chemphys.2008.12.026  0.681
2009 Berndt A, Stehfest K, Hegemann P. Mutations in Cys 128 cause extreme decelerations of the Channelrhodopsin-2 kinetics Biophysical Journal. 96: 671a. DOI: 10.1016/J.Bpj.2008.12.3547  0.786
2009 Rösler A, Hegemann P, Prigge M. Gaining control over membrane potential by light using Channelrhodopsin Biophysical Journal. 96: 23a. DOI: 10.1016/J.Bpj.2008.12.1023  0.784
2008 Ritter E, Stehfest K, Berndt A, Hegemann P, Bartl FJ. Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy. The Journal of Biological Chemistry. 283: 35033-41. PMID 18927082 DOI: 10.1074/Jbc.M806353200  0.771
2008 Bonetti C, Mathes T, van Stokkum IH, Mullen KM, Groot ML, van Grondelle R, Hegemann P, Kennis JT. Hydrogen bond switching among flavin and amino acid side chains in the BLUF photoreceptor observed by ultrafast infrared spectroscopy. Biophysical Journal. 95: 4790-802. PMID 18708458 DOI: 10.1529/Biophysj.108.139246  0.688
2008 Hagedorn R, Gradmann D, Hegemann P. Dynamics of voltage profile in enzymatic ion transporters, demonstrated in electrokinetics of proton pumping rhodopsin. Biophysical Journal. 95: 5005-13. PMID 18621842 DOI: 10.1529/Biophysj.107.125260  0.345
2008 Berthold P, Tsunoda SP, Ernst OP, Mages W, Gradmann D, Hegemann P. Channelrhodopsin-1 initiates phototaxis and photophobic responses in chlamydomonas by immediate light-induced depolarization. The Plant Cell. 20: 1665-77. PMID 18552201 DOI: 10.1105/Tpc.108.057919  0.726
2008 Hegemann P. Algal sensory photoreceptors. Annual Review of Plant Biology. 59: 167-89. PMID 18444900 DOI: 10.1046/J.1529-8817.2001.01095.X  0.401
2008 Zhang F, Prigge M, Beyrière F, Tsunoda SP, Mattis J, Yizhar O, Hegemann P, Deisseroth K. Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nature Neuroscience. 11: 631-3. PMID 18432196 DOI: 10.1038/Nn.2120  0.811
2008 Ernst OP, Sánchez Murcia PA, Daldrop P, Tsunoda SP, Kateriya S, Hegemann P. Photoactivation of channelrhodopsin. The Journal of Biological Chemistry. 283: 1637-43. PMID 17993465 DOI: 10.1074/Jbc.M708039200  0.808
2008 Hegemann P, Marwan W. SINGLE PHOTONS ARE SUFFICIENT TO TRIGGER MOVEMENT RESPONSES IN Chlamydomonas reinhardtii Photochemistry and Photobiology. 48: 99-106. DOI: 10.1111/J.1751-1097.1988.Tb02793.X  0.345
2007 Nöll G, Hauska G, Hegemann P, Lanzl K, Nöll T, von Sanden-Flohe M, Dick B. Redox properties of LOV domains: chemical versus photochemical reduction, and influence on the photocycle. Chembiochem : a European Journal of Chemical Biology. 8: 2256-64. PMID 17990262 DOI: 10.1002/Cbic.200700304  0.401
2007 Song SH, Dick B, Penzkofer A, Hegemann P. Photo-reduction of flavin mononucleotide to semiquinone form in LOV domain mutants of blue-light receptor phot from Chlamydomonas reinhardtii. Journal of Photochemistry and Photobiology. B, Biology. 87: 37-48. PMID 17292618 DOI: 10.1016/J.Jphotobiol.2006.12.007  0.408
2007 Schröder-Lang S, Schwärzel M, Seifert R, Strünker T, Kateriya S, Looser J, Watanabe M, Kaupp UB, Hegemann P, Nagel G. Fast manipulation of cellular cAMP level by light in vivo. Nature Methods. 4: 39-42. PMID 17128267 DOI: 10.1038/Nmeth975  0.806
2007 Zirak P, Penzkofer A, Lehmpfuhl C, Mathes T, Hegemann P. Absorption and emission spectroscopic characterization of blue-light receptor Slr1694 from Synechocystis sp. PCC6803. Journal of Photochemistry and Photobiology. B, Biology. 86: 22-34. PMID 16996275 DOI: 10.1016/J.Jphotobiol.2006.08.007  0.732
2007 Zirak P, Penzkofer A, Hegemann P, Mathes T. Photo dynamics of BLUF domain mutant H44R of AppA from Rhodobacter sphaeroides Chemical Physics. 335: 15-27. DOI: 10.1016/J.Chemphys.2007.03.013  0.739
2006 Gauden M, van Stokkum IH, Key JM, Lührs DCh, van Grondelle R, Hegemann P, Kennis JT. Hydrogen-bond switching through a radical pair mechanism in a flavin-binding photoreceptor. Proceedings of the National Academy of Sciences of the United States of America. 103: 10895-900. PMID 16829579 DOI: 10.1073/Pnas.0600720103  0.399
2006 Tsunoda SP, Ewers D, Gazzarrini S, Moroni A, Gradmann D, Hegemann P. H+ -pumping rhodopsin from the marine alga Acetabularia. Biophysical Journal. 91: 1471-9. PMID 16731558 DOI: 10.1529/Biophysj.106.086421  0.697
2006 Kottke T, Hegemann P, Dick B, Heberle J. The photochemistry of the light-, oxygen-, and voltage-sensitive domains in the algal blue light receptor phot. Biopolymers. 82: 373-8. PMID 16552739 DOI: 10.1002/Bip.20510  0.405
2006 Zirak P, Penzkofer A, Schiereis T, Hegemann P, Jung A, Schlichting I. Photodynamics of the small BLUF protein BlrB from Rhodobacter sphaeroides. Journal of Photochemistry and Photobiology. B, Biology. 83: 180-94. PMID 16495071 DOI: 10.1016/J.Jphotobiol.2005.12.015  0.373
2005 Li X, Gutierrez DV, Hanson MG, Han J, Mark MD, Chiel H, Hegemann P, Landmesser LT, Herlitze S. Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 102: 17816-21. PMID 16306259 DOI: 10.1073/Pnas.0509030102  0.396
2005 Hegemann P, Ehlenbeck S, Gradmann D. Multiple photocycles of channelrhodopsin. Biophysical Journal. 89: 3911-8. PMID 16169986 DOI: 10.1529/Biophysj.105.069716  0.368
2005 Song SH, Dick B, Zirak P, Penzkofer A, Schiereis T, Hegemann P. Absorption and emission spectroscopic characterisation of combined wildtype LOV1-LOV2 domain of phot from Chlamydomonas reinhardtii. Journal of Photochemistry and Photobiology. B, Biology. 81: 55-65. PMID 16111889 DOI: 10.1016/J.Jphotobiol.2005.06.003  0.401
2005 Nagel G, Szellas T, Kateriya S, Adeishvili N, Hegemann P, Bamberg E. Channelrhodopsins: directly light-gated cation channels. Biochemical Society Transactions. 33: 863-6. PMID 16042615 DOI: 10.1042/Bst0330863  0.83
2005 Zorin B, Hegemann P, Sizova I. Nuclear-gene targeting by using single-stranded DNA avoids illegitimate DNA integration in Chlamydomonas reinhardtii. Eukaryotic Cell. 4: 1264-72. PMID 16002652 DOI: 10.1128/Ec.4.7.1264-1272.2005  0.761
2005 Guo H, Kottke T, Hegemann P, Dick B. The phot LOV2 domain and its interaction with LOV1. Biophysical Journal. 89: 402-12. PMID 15879473 DOI: 10.1529/Biophysj.104.058230  0.35
2005 Holzer W, Penzkofer A, Hegemann P. Photopysical and photochemical excitation and relaxation dynamics of LOV domains of phot from Chlamydomonas reinhardtii Journal of Luminescence. 112: 444-448. DOI: 10.1016/J.Jlumin.2004.09.069  0.408
2005 Penzkofer A, Endres L, Schiereis T, Hegemann P. Yield of photo-adduct formation of LOV domains from Chlamydomonas reinhardtii by picosecond laser excitation Chemical Physics. 316: 185-194. DOI: 10.1016/J.Chemphys.2005.05.016  0.354
2005 Zirak P, Penzkofer A, Schiereis T, Hegemann P, Jung A, Schlichting I. Absorption and fluorescence spectroscopic characterization of BLUF domain of AppA from Rhodobacter sphaeroides Chemical Physics. 315: 142-154. DOI: 10.1016/J.Chemphys.2005.04.008  0.371
2005 Holzer W, Penzkofer A, Hegemann P. Absorption and emission spectroscopic characterisation of the LOV2-His domain of phot from Chlamydomonas reinhardtii Chemical Physics. 308: 79-91. DOI: 10.1016/J.Chemphys.2004.08.007  0.369
2004 Fuhrmann M, Hausherr A, Ferbitz L, Schödl T, Heitzer M, Hegemann P. Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene. Plant Molecular Biology. 55: 869-81. PMID 15604722 DOI: 10.1007/S11103-004-2150-6  0.348
2004 Schleicher E, Kowalczyk RM, Kay CW, Hegemann P, Bacher A, Fischer M, Bittl R, Richter G, Weber S. On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin. Journal of the American Chemical Society. 126: 11067-76. PMID 15339193 DOI: 10.1021/Ja049553Q  0.388
2004 Bednarz T, Losi A, Gartner W, Hegemann P, Heberle J. Functional variations among LOV domains as revealed by FT-IR difference spectroscopy. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 3: 575-9. PMID 15170487 DOI: 10.1039/B400976B  0.35
2004 Kateriya S, Nagel G, Bamberg E, Hegemann P. "Vision" in single-celled algae. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 19: 133-7. PMID 15143209 DOI: 10.1152/Nips.01517.2004  0.803
2004 Losi A, Kottke T, Hegemann P. Recording of blue light-induced energy and volume changes within the wild-type and mutated phot-LOV1 domain from Chlamydomonas reinhardtii. Biophysical Journal. 86: 1051-60. PMID 14747340 DOI: 10.1016/S0006-3495(04)74180-6  0.338
2004 Holzer W, Penzkofer A, Susdorf T, Álvarez M, Islam SDM, Hegemann P. Absorption and emission spectroscopic characterisation of the LOV2-domain of phot from Chlamydomonas reinhardtii fused to a maltose binding protein Chemical Physics. 302: 105-118. DOI: 10.1016/J.Chemphys.2004.03.017  0.396
2003 Nagel G, Szellas T, Huhn W, Kateriya S, Adeishvili N, Berthold P, Ollig D, Hegemann P, Bamberg E. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proceedings of the National Academy of Sciences of the United States of America. 100: 13940-5. PMID 14615590 DOI: 10.1073/Pnas.1936192100  0.837
2003 Kottke T, Dick B, Fedorov R, Schlichting I, Deutzmann R, Hegemann P. Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain. Biochemistry. 42: 9854-62. PMID 12924934 DOI: 10.1021/Bi034863R  0.382
2003 Fedorov R, Schlichting I, Hartmann E, Domratcheva T, Fuhrmann M, Hegemann P. Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii. Biophysical Journal. 84: 2474-82. PMID 12668455 DOI: 10.1016/S0006-3495(03)75052-8  0.421
2003 Kottke T, Heberle J, Hehn D, Dick B, Hegemann P. Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii. Biophysical Journal. 84: 1192-201. PMID 12547798 DOI: 10.1016/S0006-3495(03)74933-9  0.421
2003 Ataka K, Hegemann P, Heberle J. Vibrational spectroscopy of an algal Phot-LOV1 domain probes the molecular changes associated with blue-light reception. Biophysical Journal. 84: 466-74. PMID 12524299 DOI: 10.1016/S0006-3495(03)74866-8  0.358
2002 Nagel G, Ollig D, Fuhrmann M, Kateriya S, Musti AM, Bamberg E, Hegemann P. Channelrhodopsin-1: a light-gated proton channel in green algae. Science (New York, N.Y.). 296: 2395-8. PMID 12089443 DOI: 10.1126/Science.1072068  0.835
2002 Holzer W, Penzkofer A, Fuhrmann M, Hegemann P. Spectroscopic characterization of flavin mononucleotide bound to the LOV1 domain of Phot1 from Chlamydomonas reinhardtii. Photochemistry and Photobiology. 75: 479-87. PMID 12017473 DOI: 10.1562/0031-8655(2002)075<0479:Scofmb>2.0.Co;2  0.341
2002 Ehlenbeck S, Gradmann D, Braun FJ, Hegemann P. Evidence for a light-induced H(+) conductance in the eye of the green alga Chlamydomonas reinhardtii. Biophysical Journal. 82: 740-51. PMID 11806916 DOI: 10.1016/S0006-3495(02)75436-2  0.342
2001 Govorunova EG, Sineshchekov OA, Gärtner W, Chunaev AS, Hegemann P. Photoreceptor current and photoorientation in chlamydomonas mediated by 9-demethylchlamyrhodopsin. Biophysical Journal. 81: 2897-907. PMID 11606300 DOI: 10.1016/S0006-3495(01)75930-9  0.694
2000 Deininger W, Fuhrmann M, Hegemann P. Opsin evolution: out of wild green yonder? Trends in Genetics : Tig. 16: 158-9. PMID 10729830 DOI: 10.1016/S0168-9525(99)01959-9  0.304
1999 Ebnet E, Fischer M, Deininger W, Hegemann P. Volvoxrhodopsin, a light-regulated sensory photoreceptor of the spheroidal green alga Volvox carteri. The Plant Cell. 11: 1473-84. PMID 10449581 DOI: 10.1105/Tpc.11.8.1473  0.384
1999 Braun FJ, Hegemann P. Two light-activated conductances in the eye of the green alga Volvox carteri. Biophysical Journal. 76: 1668-78. PMID 10049347 DOI: 10.1016/S0006-3495(99)77326-1  0.415
1997 Govorunova EG, Sineshchekov OA, Hegemann P. Desensitization and Dark Recovery of the Photoreceptor Current in Chlamydomonas reinhardtii. Plant Physiology. 115: 633-642. PMID 12223832  0.682
1997 Hegemann P. Vision in microalgae. Planta. 203: 265-74. PMID 9431675 DOI: 10.1007/S004250050191  0.438
1997 Holland EM, Harz H, Uhl R, Hegemann P. Control of phobic behavioral responses by rhodopsin-induced photocurrents in Chlamydomonas. Biophysical Journal. 73: 1395-401. PMID 9284306 DOI: 10.1016/S0006-3495(97)78171-2  0.349
1996 Nonnengässer C, Holland EM, Harz H, Hegemann P. The nature of rhodopsin-triggered photocurrents in Chlamydomonas. II. Influence of monovalent ions. Biophysical Journal. 70: 932-8. PMID 8789110 DOI: 10.1016/S0006-3495(96)79636-4  0.353
1996 Holland EM, Braun FJ, Nonnengässer C, Harz H, Hegemann P. The nature of rhodopsin-triggered photocurrents in Chlamydomonas. I. Kinetics and influence of divalent ions. Biophysical Journal. 70: 924-31. PMID 8789109 DOI: 10.1016/S0006-3495(96)79635-2  0.39
1995 Deininger W, Kröger P, Hegemann U, Lottspeich F, Hegemann P. Chlamyrhodopsin represents a new type of sensory photoreceptor. The Embo Journal. 14: 5849-58. PMID 8846778 DOI: 10.1002/J.1460-2075.1995.Tb00273.X  0.416
1994 Kröger P, Hegemann P. Photophobic responses and phototaxis in Chlamydomonas are triggered by a single rhodopsin photoreceptor. Febs Letters. 341: 5-9. PMID 8137921 DOI: 10.1016/0014-5793(94)80229-7  0.397
1992 Harz H, Nonnengasser C, Hegemann P. The Photoreceptor Current of the Green Alga Chlamydomonas Philosophical Transactions of the Royal Society B. 338: 39-52. DOI: 10.1098/Rstb.1992.0127  0.427
1991 Beckmann M, Hegemann P. In vitro identification of rhodopsin in the green alga Chlamydomonas Biochemistry. 30: 3692-3697. PMID 2015225 DOI: 10.1021/Bi00229A014  0.409
1991 Harz H, Hegemann P. Rhodopsin-regulated calcium currents in Chlamydomonas Nature. 351: 489-491. DOI: 10.1038/351489A0  0.436
1991 Hegemann P, Musgrave A. Phototaxis of Chlamydomonas eugametos Pairs is Controlled by the mt+ Partner Journal of Plant Physiology. 138: 285-291. DOI: 10.1016/S0176-1617(11)80289-0  0.369
1991 Hegemann P, Gartner W, Uhl R. All-trans retinal constitutes the functional chromophore in Chlamydomonas rhodopsin Biophysical Journal. 60: 1477-1489. DOI: 10.1016/S0006-3495(91)82183-X  0.377
1990 Hegemann P, Neumeier K, Hegemann U, Kuehnle E. The role of calcium in Chlamydomonas photomovement responses as analysed by calcium channel inhibitors Photochemistry and Photobiology. 52: 575-583. PMID 2284349 DOI: 10.1111/J.1751-1097.1990.Tb01802.X  0.324
1990 Uhl R, Hegemann P. Probing visual transduction in a plant cell. Optical recording of rhodopsin-induced structural changes from Chlamydomonas reinhardtii Biophysical Journal. 58: 1295-1302. DOI: 10.1016/S0006-3495(90)82469-3  0.351
1990 Uhl R, Hegemann P. Adaptation of chlamydomonas phototaxis: I. A light-scattering apparatus for measuring the phototactic rate of microorganisms with high time resolution Cell Motility and the Cytoskeleton. 15: 230-244. DOI: 10.1002/Cm.970150406  0.376
1989 Hegemann P, Bruck B. Light-induced stop response in chlamydomonas reinhartii: Occurrence and adaptation phenomena Cell Motility and the Cytoskeleton. 14: 501-515. DOI: 10.1002/Cm.970140408  0.375
1988 Hegemann P, Hegemann U, Foster KW. Reversible bleaching of Chlamydomonas reinhardtii rhodopsin in vivo. Photochemistry and Photobiology. 48: 123-8. PMID 3217436 DOI: 10.1111/J.1751-1097.1988.Tb02796.X  0.651
1988 Marwan W, Hegemann P, Oesterhelt D. Single photon detection by an archaebacterium. Journal of Molecular Biology. 199: 663-4. PMID 3127593 DOI: 10.1016/0022-2836(88)90309-9  0.553
1987 Hegemann P, Blanck A, Vogelsang-Wenke H, Lottspeich F, Oesterhelt D. The halo-opsin gene. I. Identification and isolation. The Embo Journal. 6: 259-64. PMID 15981335 DOI: 10.1002/J.1460-2075.1987.Tb04748.X  0.471
1986 Oesterhelt D, Hegemann P, Tavan P, Schulten K. Trans-cis isomerization of retinal and a mechanism for ion translocation in halorhodopsin European Biophysics Journal. 14: 123-129. DOI: 10.1007/Bf00263069  0.499
1985 Oesterhelt D, Hegemann P, Tittor J. The photocycle of the chloride pump halorhodopsin. II: Quantum yields and a kinetic model. The Embo Journal. 4: 2351-6. PMID 15938054 DOI: 10.1002/J.1460-2075.1985.Tb03938.X  0.512
1985 Hegemann P, Oesterbelt D, Steiner M. The photocycle of the chloride pump halorhodopsin. I: Azide-catalyzed deprotonation of the chromophore is a side reaction of photocycle intermediates inactivating the pump The Embo Journal. 4: 2347-2350. PMID 15938053 DOI: 10.1002/J.1460-2075.1985.Tb03937.X  0.33
1985 Polland HJ, Franz MA, Zinth W, Kaiser W, Hegemann P, Oesterhelt D. Picosecond events in the photochemical cycle of the light-driven chloride-pump halorhodopsin. Biophysical Journal. 47: 55-9. PMID 3978190 DOI: 10.1016/S0006-3495(85)83876-5  0.576
1985 Alshuth T, Stockburger M, Hegemann P, Oesterhelt D. Structure of the retinal chromophore in halorhodopsin. A resonance Raman study Febs Letters. 179: 55-59. DOI: 10.1016/0014-5793(85)80190-3  0.589
1985 Hegemann P, Oesterhelt D, Bamberg E. The transport activity of the light-driven chloride pump halorhodopsin is regulated by green and blue light Bba - Biomembranes. 819: 195-205. DOI: 10.1016/0005-2736(85)90174-9  0.703
1984 Barnberg E, Hegemann P, Oesterhelt D. The chromoprotein of halorhodopsin is the light-driven electrogenic chloride pump in halobacterium halobiumt. Biochemistry. 23: 6216-21. PMID 24409552 DOI: 10.1021/Bi00320A050  0.505
1984 Bamberg E, Hegemann P, Oesterhelt D. Reconstitution of halorhodopsin in black lipid membranes. Progress in Clinical and Biological Research. 164: 73-9. PMID 6522408  0.546
1984 Bamberg E, Hegemann P, Oesterhelt D. Reconstitution of the light-driven electrogenic ion pump halorhodopsin in black lipid membranes Bba - Biomembranes. 773: 53-60. DOI: 10.1016/0005-2736(84)90549-2  0.665
1982 Hegemann P, Steiner M, Oesterhelt D. Isolation and characterization of the retinal-binding component of halorhodopsin. The Embo Journal. 1: 1177-83. PMID 16453434 DOI: 10.1002/J.1460-2075.1982.Tb00010.X  0.481
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