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Edwin M. Southern, Ph.D. - Publications

Affiliations: 
University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Area:
DNA organization, chromosome structure
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Year Citation  Score
2015 Southern E. The early days of blotting. Methods in Molecular Biology (Clifton, N.J.). 1312: 1-3. PMID 26043982 DOI: 10.1007/978-1-4939-2694-7_1  0.403
2008 Birikh KR, Korshun VA, Bernad PL, Malakhov AD, Milner N, Khan S, Southern EM, Shchepinov MS. Novel mass tags for single nucleotide polymorphism detection. Analytical Chemistry. 80: 2342-50. PMID 17973350 DOI: 10.1021/Ac071291Y  0.317
2005 Egeland RD, Southern EM. Electrochemically directed synthesis of oligonucleotides for DNA microarray fabrication. Nucleic Acids Research. 33: e125. PMID 16085751 DOI: 10.1093/Nar/Gni117  0.416
2005 Moorcroft MJ, Meuleman WR, Latham SG, Nicholls TJ, Egeland RD, Southern EM. In situ oligonucleotide synthesis on poly(dimethylsiloxane): a flexible substrate for microarray fabrication. Nucleic Acids Research. 33: e75. PMID 15870385 DOI: 10.1093/Nar/Gni075  0.349
2005 Sohail M, Doran G, Kang S, Akhtar S, Southern EM. Structural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy. Journal of Drug Targeting. 13: 61-70. PMID 15848955 DOI: 10.1080/10611860400003825  0.346
2004 Hussain M, Shchepinov M, Sohail M, Benter IF, Hollins AJ, Southern EM, Akhtar S. A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 99: 139-55. PMID 15342187 DOI: 10.1016/J.Jconrel.2004.06.009  0.351
2004 Ooms M, Verhoef K, Southern E, Huthoff H, Berkhout B. Probing alternative foldings of the HIV-1 leader RNA by antisense oligonucleotide scanning arrays. Nucleic Acids Research. 32: 819-27. PMID 14762209 DOI: 10.1093/Nar/Gkh206  0.346
2003 Sohail M, Doran G, Riedemann J, Macaulay V, Southern EM. A simple and cost-effective method for producing small interfering RNAs with high efficacy. Nucleic Acids Research. 31: e38. PMID 12655026 DOI: 10.1093/Nar/Gng038  0.329
2003 Bohula EA, Salisbury AJ, Sohail M, Playford MP, Riedemann J, Southern EM, Macaulay VM. The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. The Journal of Biological Chemistry. 278: 15991-7. PMID 12604614 DOI: 10.1074/Jbc.M300714200  0.305
2002 Sohail M, Southern EM. Oligonucleotide scanning arrays: application to high-throughput screening for effective antisense reagents and the study of nucleic acid interactions. Advances in Biochemical Engineering/Biotechnology. 77: 43-56. PMID 12227736 DOI: 10.1007/3-540-45713-5_3  0.395
2002 Housby JN, Southern EM. Thermus scotoductus and Rhodothermus marinus DNA ligases have higher ligation efficiencies than thermus thermophilus DNA ligase. Analytical Biochemistry. 302: 88-94. PMID 11846380 DOI: 10.1006/Abio.2001.5532  0.392
2001 Sohail M, Southern EM. Using oligonucleotide scanning arrays to find effective antisense reagents. Methods in Molecular Biology (Clifton, N.J.). 170: 181-99. PMID 11357682 DOI: 10.1385/1-59259-234-1:181  0.306
2000 Mir KU, Southern EM. Sequence variation in genes and genomic DNA: methods for large-scale analysis. Annual Review of Genomics and Human Genetics. 1: 329-60. PMID 11701633 DOI: 10.1146/Annurev.Genom.1.1.329  0.377
2000 Nguyen HK, Southern EM. Minimising the secondary structure of DNA targets by incorporation of a modified deoxynucleoside: implications for nucleic acid analysis by hybridisation. Nucleic Acids Research. 28: 3904-9. PMID 11024169 DOI: 10.1093/Nar/28.20.3904  0.372
2000 Housby JN, Thorbjarnardóttir SH, Jónsson ZO, Southern EM. Optimised ligation of oligonucleotides by thermal ligases: comparison of Thermus scotoductus and Rhodothermus marinus DNA ligases to other thermophilic ligases. Nucleic Acids Research. 28: E10. PMID 10637340 DOI: 10.1093/Nar/28.3.E10  0.345
2000 Shchepinov MS, Korshun VA, Egeland RD, Southern EM. Tritylisation of pyrene, perylene and coronene: A new family of switchable fluorescent labels Tetrahedron Letters. 41: 4943-4948. DOI: 10.1016/S0040-4039(00)00737-1  0.329
2000 Shchepinov MS, Chalk R, Southern EM. Trityl tags for encoding in combinatorial synthesis Tetrahedron. 56: 2713-2724. DOI: 10.1016/S0040-4020(00)00223-4  0.328
1999 Shchepinov MS, Mir KU, Elder JK, Frank-Kamenetskii MD, Southern EM. Oligonucleotide dendrimers: stable nano-structures. Nucleic Acids Research. 27: 3035-41. PMID 10454597 DOI: 10.1093/Nar/27.15.3035  0.414
1999 Mir KU, Southern EM. Determining the influence of structure on hybridization using oligonucleotide arrays. Nature Biotechnology. 17: 788-92. PMID 10429245 DOI: 10.1038/11732  0.367
1999 Sohail M, Akhtar S, Southern EM. The folding of large RNAs studied by hybridization to arrays of complementary oligonucleotides. Rna (New York, N.Y.). 5: 646-55. PMID 10334335 DOI: 10.1017/S1355838299982195  0.327
1999 Southern E, Mir K, Shchepinov M. Molecular interactions on microarrays. Nature Genetics. 21: 5-9. PMID 9915493 DOI: 10.1038/4429  0.665
1999 Nguyen H, Southern EM. Minimizing the secondary structure of DNA targets with a modified deoxynucleoside and its implication for nucleic acid analysis by hybridization Nature Genetics. 23: 66-66. DOI: 10.1038/14377  0.41
1998 Housby JN, Southern EM. Fidelity of DNA ligation: a novel experimental approach based on the polymerisation of libraries of oligonucleotides. Nucleic Acids Research. 26: 4259-66. PMID 9722647 DOI: 10.1093/Nar/26.18.4259  0.389
1998 Case-Green SC, Mir KU, Pritchard CE, Southern EM. Analysing genetic information with DNA arrays. Current Opinion in Chemical Biology. 2: 404-10. PMID 9691078 DOI: 10.1016/S1367-5931(98)80016-1  0.414
1997 Shchepinov MS, Udalova IA, Bridgman AJ, Southern EM. Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes. Nucleic Acids Research. 25: 4447-54. PMID 9358151 DOI: 10.1093/Nar/25.22.4447  0.378
1997 Pritchard CE, Southern EM. Effects of base mismatches on joining of short oligodeoxynucleotides by DNA ligases. Nucleic Acids Research. 25: 3403-7. PMID 9254695 DOI: 10.1093/Nar/25.17.3403  0.395
1997 Milner N, Mir KU, Southern EM. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nature Biotechnology. 15: 537-41. PMID 9181575 DOI: 10.1038/Nbt0697-537  0.376
1997 Shchepinov MS, Case-Green SC, Southern EM. Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays. Nucleic Acids Research. 25: 1155-61. PMID 9092624 DOI: 10.1093/Nar/25.6.1155  0.327
1997 Gray DE, Case-Green SC, Fell TS, Dobson PJ, Southern EM. Ellipsometric and interferometric characterization of DNA probes immobilized on a combinatorial array Langmuir. 13: 2833-2842.  0.303
1996 Southern EM. High-density gridding: techniques and applications. Current Opinion in Biotechnology. 7: 85-8. PMID 8742380 DOI: 10.1016/S0958-1669(96)80100-5  0.329
1995 Southern EM. DNA fingerprinting by hybridisation to oligonucleotide arrays. Electrophoresis. 16: 1539-42. PMID 8582332  0.331
1994 Williams JC, Case-Green SC, Mir KU, Southern EM. Studies of oligonucleotide interactions by hybridisation to arrays: the influence of dangling ends on duplex yield. Nucleic Acids Research. 22: 1365-7. PMID 8190626 DOI: 10.1093/Nar/22.8.1365  0.44
1994 Case-Green SC, Southern EM. Studies on the base pairing properties of deoxyinosine by solid phase hybridisation to oligonucleotides. Nucleic Acids Research. 22: 131-6. PMID 8121796 DOI: 10.1093/Nar/22.2.131  0.305
1994 Southern EM, Maskos U. Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides. Journal of Biotechnology. 35: 217-27. PMID 7765059 DOI: 10.1016/0168-1656(94)90037-X  0.411
1994 Southern EM, Case-Green SC, Elder JK, Johnson M, Mir KU, Wang L, Williams JC. Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids. Nucleic Acids Research. 22: 1368-73. PMID 7514785 DOI: 10.1093/Nar/22.8.1368  0.375
1993 Maskos U, Southern EM. A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. Nucleic Acids Research. 21: 4663-9. PMID 8233815 DOI: 10.1093/Nar/21.20.4663  0.372
1993 Maskos U, Southern EM. A novel method for the analysis of multiple sequence variants by hybridisation to oligonucleotides. Nucleic Acids Research. 21: 2267-8. PMID 7684837 DOI: 10.1093/Nar/21.9.2267  0.334
1992 Maskos U, Southern EM. Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ. Nucleic Acids Research. 20: 1679-84. PMID 1579459 DOI: 10.1093/Nar/20.7.1679  0.36
1992 Maskos U, Southern EM. Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation. Nucleic Acids Research. 20: 1675-8. PMID 1579458 DOI: 10.1093/Nar/20.7.1675  0.408
1992 Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. 1975. Biotechnology (Reading, Mass.). 24: 122-39. PMID 1422006  0.304
1992 Southern EM, Maskos U, Elder JK. Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models. Genomics. 13: 1008-17. PMID 1380482 DOI: 10.1016/0888-7543(92)90014-J  0.42
1988 Anand R, Honeycombe J, Whittaker PA, Elder JK, Southern EM. Clones from an 840-kb fragment containing the 5' region of the DMD locus enriched by pulsed field gel electrophoresis. Genomics. 3: 177-86. PMID 3066744 DOI: 10.1016/0888-7543(88)90077-8  0.359
1988 Whittaker PA, Campbell AJ, Southern EM, Murray NE. Enhanced recovery and restriction mapping of DNA fragments cloned in a new lambda vector. Nucleic Acids Research. 16: 6725-36. PMID 2841642 DOI: 10.1093/Nar/16.14.6725  0.385
1987 Southern EM, Anand R, Brown WR, Fletcher DS. A model for the separation of large DNA molecules by crossed field gel electrophoresis. Nucleic Acids Research. 15: 5925-43. PMID 3627974 DOI: 10.1093/Nar/15.15.5925  0.362
1986 Elder JK, Green DK, Southern EM. Automatic reading of DNA sequencing gel autoradiographs using a large format digital scanner. Nucleic Acids Research. 14: 417-24. PMID 3753777 DOI: 10.1093/Nar/14.1.417  0.366
1986 Whittaker PA, Southern EM. Ultraviolet irradiation of DNA: a way of generating partial digests for rapid restriction site mapping. Gene. 41: 129-34. PMID 3009271 DOI: 10.1016/0378-1119(86)90276-3  0.35
1985 Sealey PG, Whittaker PA, Southern EM. Removal of repeated sequences from hybridisation probes. Nucleic Acids Research. 13: 1905-22. PMID 4000947 DOI: 10.1093/Nar/13.6.1905  0.374
1983 Elder JK, Southern EM. Measurement of DNA length by gel electrophoresis II: Comparison of methods for relating mobility to fragment length. Analytical Biochemistry. 128: 227-31. PMID 6303153 DOI: 10.1016/0003-2697(83)90369-X  0.316
1983 Elder JK, Amos A, Southern EM, Shippey GA. Measurement of DNA length by gel electrophoresis. I. Improved accuracy of mobility measurements using a digital microdensitometer and computer processing. Analytical Biochemistry. 128: 223-6. PMID 6221672 DOI: 10.1016/0003-2697(83)90368-8  0.355
1982 Southern EM. Application of DNA analysis to mapping the human genome. Cytogenetics and Cell Genetics. 32: 52-7. PMID 7140369 DOI: 10.1159/000131686  0.33
1982 Southern EM. New methods for analysing DNA make genetics simpler. Biochemical Society Transactions. 10: 1-4. PMID 6277709 DOI: 10.1042/Bst0100001  0.326
1979 Southern EM. Measurement of DNA length by gel electrophoresis. Analytical Biochemistry. 100: 319-23. PMID 525781 DOI: 10.1016/0003-2697(79)90235-5  0.342
1979 Southern E. Gel electrophoresis of restriction fragments. Methods in Enzymology. 68: 152-76. PMID 232210 DOI: 10.1016/0076-6879(79)68011-4  0.429
1976 Selsing E, Leslie AG, Arnott S, Gall JG, Skinner DM, Southern EM, Spencer JH, Harbers K. Conformations of satellite DNAs. Nucleic Acids Research. 3: 2451-7. PMID 995639 DOI: 10.1093/Nar/3.10.2451  0.391
1975 Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology. 98: 503-17. PMID 1195397 DOI: 10.1016/S0022-2836(75)80083-0  0.409
1975 Southern EM. Long range periodicities in mouse satellite DNA. Journal of Molecular Biology. 94: 51-69. PMID 1142436 DOI: 10.1016/0022-2836(75)90404-0  0.388
1975 Biro PA, Carr-Brown A, Southern EM, Walker PM. Partial sequence analysis of mouse satellite DNA evidence for short range periodicities. Journal of Molecular Biology. 94: 71-86. PMID 806696 DOI: 10.1016/0022-2836(75)90405-2  0.429
1974 Southern EM, Roizes G. The action of a restriction endonuclease on higher organism DNA. Cold Spring Harbor Symposia On Quantitative Biology. 38: 429-33. PMID 4598639 DOI: 10.1101/Sqb.1974.038.01.046  0.325
1973 Ford PJ, Southern EM. Different sequences for 5S RNA in kidney cells and ovaries of Xenopus laevis. Nature: New Biology. 241: 7-12. PMID 4512331 DOI: 10.1038/Newbio241007A0  0.306
1971 Southern EM. Effects of sequence divergence on the reassociation properties of repetitive DNAs. Nature: New Biology. 232: 82-3. PMID 5285344 DOI: 10.1038/Newbio232082A0  0.405
1970 Southern EM. Base sequence and evolution of guinea-pig alpha-satellite DNA. Nature. 227: 794-8. PMID 4317352 DOI: 10.1038/227794A0  0.395
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