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Nael A. McCarty - Publications

Affiliations: 
Georgia Institute of Technology, Atlanta, GA 
Area:
Molecular Biology, Ecology Biology, Neuroscience Biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Infield DT, Strickland KM, Gaggar A, McCarty NA. The molecular evolution of function in the CFTR chloride channel. The Journal of General Physiology. 153. PMID 34647973 DOI: 10.1085/jgp.202012625  0.303
2020 Cui G, Cottrill KA, Strickland KM, Imhoff BR, McCarty NA. Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of CFTR Channel Activity Biophysical Journal. 118: 588a. DOI: 10.1016/J.Bpj.2019.11.3187  0.35
2019 Cui G, Hong J, Chung-Davidson YW, Infield D, Xu X, Li J, Simhaev L, Khazanov N, Stauffer B, Imhoff B, Cottrill K, Blalock JE, Li W, Senderowitz H, Sorscher E, ... McCarty NA, et al. An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters. Developmental Cell. PMID 31679858 DOI: 10.1016/J.Devcel.2019.09.017  0.411
2019 Cui G, Stauffer BB, Imhoff BR, Rab A, Hong JS, Sorscher EJ, McCarty NA. VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level. Scientific Reports. 9: 13460. PMID 31530897 DOI: 10.1038/S41598-019-49921-4  0.346
2019 Strickland KM, Stock G, Cui G, Hwang H, Infield DT, Schmidt-Krey I, McCarty NA, Gumbart JC. ATP-Dependent Signaling in Simulations of a Revised Model of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). The Journal of Physical Chemistry. B. PMID 30921517 DOI: 10.1021/Acs.Jpcb.8B11970  0.373
2019 Cui G, Cottrill KA, McGill KA, Imhoff B, McCarty NA. Human CFTR Channel Function is Regulated by Cholesterol Biophysical Journal. 116: 249a. DOI: 10.1016/J.Bpj.2018.11.1360  0.357
2019 Cottrill KA, Stauffer BB, McCarty NA. Determining the Mechanism of SMase-Mediated Inhibition of CFTR Current in Primary Bronchial Epithelial Cells Biophysical Journal. 116: 222a-223a. DOI: 10.1016/J.Bpj.2018.11.1225  0.302
2019 Strickland KM, Stauffer BB, Uddin YM, Imhoff BR, Schmidt-Krey I, McCarty NA. Effects of Lipid and Detergent Environments on Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function and Structure Biophysical Journal. 116: 222a. DOI: 10.1016/J.Bpj.2018.11.1222  0.335
2017 Mojib N, Xu J, Bartolek Z, Imhoff B, McCarty NA, Shin CH, Kubanek J. Zebrafish aversive taste co-receptor is expressed in both chemo- and mechanosensory cells and plays a role in lateral line development. Scientific Reports. 7: 13475. PMID 29044184 DOI: 10.1038/S41598-017-14042-3  0.314
2017 Farinha CM, Miller E, McCarty N. Protein and lipid interactions - Modulating CFTR trafficking and rescue. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 28887112 DOI: 10.1016/J.Jcf.2017.08.014  0.349
2017 Simhaev L, McCarty NA, Ford RC, Senderowitz H. Molecular Dynamics Flexible Fitting (MDFF) Simulations Identify New Models of Closed State CFTR. Journal of Chemical Information and Modeling. PMID 28657312 DOI: 10.1021/Acs.Jcim.7B00091  0.389
2017 Stauffer BB, Cui G, Cottrill KA, Infield DT, McCarty NA. Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Scientific Reports. 7: 2931. PMID 28592822 DOI: 10.1038/s41598-017-03103-2  0.328
2017 Zang X, Pérez JJ, Jones CM, Monge ME, McCarty NA, Stecenko AA, Fernández FM. Comparison of Ambient and Atmospheric Pressure Ion Sources for Cystic Fibrosis Exhaled Breath Condensate Ion Mobility-Mass Spectrometry Metabolomics. Journal of the American Society For Mass Spectrometry. PMID 28364225 DOI: 10.1007/S13361-017-1660-9  0.302
2016 Cui G, Khazanov N, Stauffer B, Infield DT, Imhoff BR, Senderowitz H, McCarty NA. Potentiators exert distinct effects on human, murine, and Xenopus CFTR. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00056.2016. PMID 27288484 DOI: 10.1152/Ajplung.00056.2016  0.329
2016 Infield DT, Cui G, Kuang C, McCarty NA. Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator. American Journal of Physiology. Lung Cellular and Molecular Physiology. 310: L403-14. PMID 26684250 DOI: 10.1152/Ajplung.00259.2015  0.397
2016 Stock G, McCarty N, Gumbart JC. Refinement of a Recent CFTR Homology Model Guided by Pore Formation Biophysical Journal. 110: 140a-141a. DOI: 10.1016/J.Bpj.2015.11.799  0.393
2016 Cui G, Khazanov N, Stauffer BB, Infield DT, Imhoff BR, Senderowitz H, McCarty NA. CFTR Potentiators Exert Different Effects on Human, Murine, and Xenopus CFTR Biophysical Journal. 110: 452a. DOI: 10.1016/J.Bpj.2015.11.2425  0.396
2015 Cui G, McCarty NA. Murine and human CFTR exhibit different sensitivities to CFTR potentiators. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00181.2015. PMID 26209275 DOI: 10.1152/Ajplung.00181.2015  0.4
2015 Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M. Junctional abnormalities in human airway epithelial cells expressing F508del CFTR. American Journal of Physiology. Lung Cellular and Molecular Physiology. 309: L475-87. PMID 26115671 DOI: 10.1152/Ajplung.00060.2015  0.34
2015 Stock G, Cui G, McCarty NA, Gumbart JC. Refinement and Evaluation of a CFTR Homology Model and Identification of Residues Controlling Channel Gating Biophysical Journal. 108: 127a. DOI: 10.1016/J.Bpj.2014.11.708  0.415
2015 Infield DT, Cui G, Kuang C, McCarty NA. Positioning of the First Extracellular Loop of CFTR Has Significant Effects on CFTR Gating Biophysical Journal. 108: 441a. DOI: 10.1016/J.Bpj.2014.11.2411  0.383
2015 Stauffer B, Cui G, Infield DT, McCarty N. Inhibition of the CFTR Chloride Channel by Sphingomyelinase Biophysical Journal. 108: 435a. DOI: 10.1016/J.Bpj.2014.11.2377  0.407
2014 Cui G, Rahman KS, Infield DT, Kuang C, Prince CZ, McCarty NA. Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR. The Journal of General Physiology. 144: 159-79. PMID 25024266 DOI: 10.1085/Jgp.201311122  0.38
2014 Infield DT, Cui G, Kuang C, McCarty NA. Probing Structure and Conformational Changes in the Extracellular Loops of CFTR Biophysical Journal. 106: 148a. DOI: 10.1016/J.Bpj.2013.11.854  0.345
2014 Cui G, Kuang C, Prince CZ, McCarty NA. Mouse CFTR Exhibits Multiple Characteristic Differences from Human CFTR Biophysical Journal. 106: 148a. DOI: 10.1016/J.Bpj.2013.11.853  0.385
2013 Rahman KS, Cui G, Harvey SC, McCarty NA. Modeling the conformational changes underlying channel opening in CFTR. Plos One. 8: e74574. PMID 24086355 DOI: 10.1371/Journal.Pone.0074574  0.403
2013 Cui G, Freeman CS, Knotts T, Prince CZ, Kuang C, McCarty NA. Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function. The Journal of Biological Chemistry. 288: 20758-67. PMID 23709221 DOI: 10.1074/Jbc.M113.476226  0.4
2013 Cui G, Wang J, Kuang C, Prince CZ, Jordan IK, McCarty NA. The Structural and Functional Imporatnce of Type II Divergent Amino Acids in the Cystic Fibrosis Transmembrane Conductance Regulator Biophysical Journal. 104: 625a. DOI: 10.1016/J.Bpj.2012.11.3458  0.403
2013 Rahman KS, Cui G, McCarty NA, Harvey SC. Molecular Dynamics Simulations of CFTR Gating and Conductance Biophysical Journal. 104: 624a-625a. DOI: 10.1016/J.Bpj.2012.11.3457  0.397
2012 Cui G, Song B, Turki HW, McCarty NA. Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers. PflüGers Archiv : European Journal of Physiology. 463: 405-18. PMID 22160394 DOI: 10.1007/S00424-011-1035-1  0.345
2012 Cui G, Kuang C, Prince CZ, McCarty NA. Three Charged Amino Acids in the Outer Vestibule of CFTR Stabilize the Open Pore Architecture Biophysical Journal. 102: 548a. DOI: 10.1016/J.Bpj.2011.11.2989  0.357
2012 Shefaet Rahman K, Cui G, McCarty NA, Harvey SC. A Homology-Based Molecular Model of the Closed State of Human CFTR Biophysical Journal. 102: 547a. DOI: 10.1016/J.Bpj.2011.11.2985  0.418
2011 Brown MB, Haack KK, Pollack BP, Millard-Stafford M, McCarty NA. Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R605-15. PMID 21228336 DOI: 10.1152/Ajpregu.00660.2010  0.373
2011 Haack KKV, McCarty NA. Functional consequences of GPCR heterodimerization: GPCRs as allosteric modulators Pharmaceuticals. 4: 509-523. DOI: 10.3390/Ph4030509  0.327
2011 Cui G, Prince CZ, McCarty NA. Two Salt Bridges Differentially Contribute to Maintenance of CFTR Channel Function Biophysical Journal. 100: 264a. DOI: 10.1016/J.Bpj.2010.12.1657  0.393
2010 Cohen SP, Haack KK, Halstead-Nussloch GE, Bernard KF, Hatt H, Kubanek J, McCarty NA. Identification of RL-TGR, a coreceptor involved in aversive chemical signaling. Proceedings of the National Academy of Sciences of the United States of America. 107: 12339-44. PMID 20566865 DOI: 10.1073/Pnas.1000343107  0.408
2010 Haack KK, Tougas MR, Jones KT, El-Dahr SS, Radhakrishna H, McCarty NA. A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor. Journal of Biomolecular Screening. 15: 251-60. PMID 20150590 DOI: 10.1177/1087057109360254  0.681
2010 Cui G, Freeman C, McCarty NA. Riding the Conformational Wave to the Open Channel State in the CFTR Chloride Channel Biophysical Journal. 98: 323a. DOI: 10.1016/J.Bpj.2009.12.1750  0.397
2009 Thompson CH, Olivetti PR, Fuller MD, Freeman CS, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. The Journal of Biological Chemistry. 284: 26051-62. PMID 19574231 DOI: 10.1074/Jbc.M109.031724  0.377
2009 Thompson CH, Freeman CS, French RJ, McCarty N. Pharmacological Characterization of GaTx2, a Peptide Inhibitor of ClC-2 Chloride Channels Biophysical Journal. 96: 470a. DOI: 10.1016/J.Bpj.2008.12.2420  0.375
2008 Mosser VA, Jones KT, Hoffman KM, McCarty NA, Jackson DA. Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors. Journal of Molecular Signaling. 3: 20. PMID 19055777 DOI: 10.1186/1750-2187-3-20  0.667
2008 Jordan IK, Kota KC, Cui G, Thompson CH, McCarty NA. Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters. Proceedings of the National Academy of Sciences of the United States of America. 105: 18865-70. PMID 19020075 DOI: 10.1073/Pnas.0806306105  0.4
2008 Cui G, Zhang ZR, O'Brien AR, Song B, McCarty NA. Mutations at arginine 352 alter the pore architecture of CFTR. The Journal of Membrane Biology. 222: 91-106. PMID 18421494 DOI: 10.1007/S00232-008-9105-9  0.349
2007 Fuller MD, Thompson CH, Zhang ZR, Freeman CS, Schay E, Szakács G, Bakos E, Sarkadi B, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin. The Journal of Biological Chemistry. 282: 37545-55. PMID 17951250 DOI: 10.1074/Jbc.M708079200  0.407
2005 Zhang ZR, Song B, McCarty NA. State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 280: 41997-2003. PMID 16227620 DOI: 10.1074/Jbc.M510242200  0.403
2005 Fuller MD, Zhang ZR, Cui G, McCarty NA. The block of CFTR by scorpion venom is state-dependent. Biophysical Journal. 89: 3960-75. PMID 16183882 DOI: 10.1529/biophysj.105.060731  0.317
2004 Zhang ZR, Zeltwanger S, McCarty NA. Steady-state interactions of glibenclamide with CFTR: Evidence for multiple sites in the pore Journal of Membrane Biology. 199: 15-28. PMID 15366420 DOI: 10.1007/S00232-004-0672-0  0.354
2004 Fuller MD, Zhang ZR, Cui G, Kubanek J, McCarty NA. Inhibition of CFTR channels by a peptide toxin of scorpion venom. American Journal of Physiology. Cell Physiology. 287: C1328-41. PMID 15240343 DOI: 10.1152/Ajpcell.00162.2004  0.421
2002 Zhang ZR, Zeltwanger S, Smith SS, Dawson DC, McCarty NA. Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L135-45. PMID 11741825 DOI: 10.1152/Ajplung.2002.282.1.L135  0.373
2002 Machaca K, Qu Z, Kuruma A, Hartzell HC, McCarty N. The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system Current Topics in Membranes. 53: 3-39. DOI: 10.1016/S1063-5823(02)53026-X  0.325
2001 Smith SS, Liu X, Zhang ZR, Sun F, Kriewall TE, Mccarty NA, Dawson DC. CFTR: Covalent and noncovalent modification suggests a role for fixed charges in anion conduction Journal of General Physiology. 118: 407-431. PMID 11585852 DOI: 10.1085/Jgp.118.4.407  0.314
2001 McCarty NA, Zhang ZR. Identification of a region of strong discrimination in the pore of CFTR American Journal of Physiology - Lung Cellular and Molecular Physiology. 281. PMID 11557589 DOI: 10.1152/Ajplung.2001.281.4.L852  0.366
2000 Zhang ZR, McDonough SI, McCarty NA. Interaction between permeation and gating in a putative pore domain mutant in the cystic fibrosis transmembrane conductance regulator Biophysical Journal. 79: 298-313. PMID 10866956 DOI: 10.1016/S0006-3495(00)76292-8  0.415
2000 Zhang ZR, Zeltwanger S, McCarty NA. Direct comparison of NPPB and DPC as probes of CFTR expressed in Xenopus oocytes Journal of Membrane Biology. 175: 35-52. PMID 10811966 DOI: 10.1007/S002320001053  0.37
1994 McDonough S, Davidson N, Lester HA, McCarty NA. Novel pore-lining residues in CFTR that govern permeation and open-channel block. Neuron. 13: 623-34. PMID 7522483 DOI: 10.1016/0896-6273(94)90030-2  0.314
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