Lawrence F. Brass - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Pharmacology, Cell Biology

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim OV, Litvinov RI, Gagne AL, French DL, Brass LF, Weisel JW. Megakaryocyte-induced contraction of plasma clots: Cellular mechanisms and structural mechanobiology. Blood. PMID 37944157 DOI: 10.1182/blood.2023021545  0.389
2023 Gupta S, Cooper M, Zhao X, Yarman Y, Thomson H, DeHelian D, Brass LF, Ma P. A regulatory node involving Gα, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists. Journal of Thrombosis and Haemostasis : Jth. PMID 37657560 DOI: 10.1016/j.jtha.2023.08.022  0.334
2020 DeCortin ME, Brass LF, Diamond SL. Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry. Research and Practice in Thrombosis and Haemostasis. 4: 1158-1166. PMID 33134782 DOI: 10.1002/rth2.12405  0.363
2020 Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LF. Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32929010 DOI: 10.1073/Pnas.2007642117  0.515
2020 DeHelian DJ, Gupta S, Wu J, Thorsheim CL, Estevez B, Cooper M, Litts K, Lee-Sundlov MM, Hoffmeister K, Poncz M, Ma P, Brass LF. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. Blood. PMID 32542378 DOI: 10.1182/Blood.2019003251  0.571
2020 Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Advances. 4: 76-86. PMID 31899801 DOI: 10.1182/Blood-2019-129175  0.582
2019 Storrie B, Rhee SW, Pokrovskaya ID, Ling K, Vedanaparti Y, Aronova M, Stalker TJ, Brass LF, Leapman R. Platelet Activation State Intermixing in a Venous Puncture Model Indicates Novel Patterns of Thrombus Formation. Blood. 134: 9. PMID 31724024 DOI: 10.1182/Blood-2019-130805  0.451
2019 Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ. Interrelationships between structure and function during the hemostatic response to injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674670 DOI: 10.1073/Pnas.1813642116  0.497
2018 Ma P, Gupta S, Sampietro S, DeHelian D, Tutwiler V, Tang A, Stalker TJ, Brass LF. RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. Blood Advances. 2: 2145-2155. PMID 30150297 DOI: 10.1182/Bloodadvances.2017008508  0.573
2018 Mirramezani M, Herbig BA, Stalker TJ, Nettey L, Cooper M, Weisel JW, Diamond SL, Sinno T, Brass LF, Shadden SC, Tomaiuolo M. Platelet packing density is an independent regulator of the hemostatic response to injury. Journal of Thrombosis and Haemostasis : Jth. PMID 29488682 DOI: 10.1111/Jth.13986  0.478
2018 Chen X, Gupta S, Cooper M, Dehelian D, Brass LF, Ma P. Decoding Gq Signaling in Platelets Blood. 132: 866-866. DOI: 10.1182/Blood-2018-99-111385  0.493
2018 Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ. Abstract 530: Hemostasis Revisited: a Combined Light and Electron Microscopy Analysis of Hemostatic Plug Formation in vivo Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.530  0.366
2018 Stalker TJ, Nettey L, Matzko C, Poventud-Fuentes I, Sinno T, Brass LF, Tomaiuolo M. Abstract 363: Platelet Mass Retraction is a Negative Feedback Regulator of Thrombin Generation and Activity Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.363  0.457
2017 Shen J, Sampietro S, Wu J, Tang J, Gupta S, Matzko CN, Tang C, Yu Y, Brass LF, Zhu L, Stalker TJ. Coordination of platelet agonist signaling during the hemostatic response in vivo. Blood Advances. 1: 2767-2775. PMID 29296928 DOI: 10.1182/Bloodadvances.2017009498  0.557
2017 Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, ... ... Brass LF, et al. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. Journal of Thrombosis and Haemostasis : Jth. PMID 29045015 DOI: 10.1111/Jth.13875  0.528
2017 Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Scientific Reports. 7: 4275. PMID 28655899 DOI: 10.1038/S41598-017-04494-Y  0.461
2017 Ueda Y, Mohammed I, Song D, Gullipalli D, Zhou L, Sato S, Wang Y, Gupta S, Cheng Z, Wang H, Bao J, Mao Y, Brass L, Zheng XL, Miwa T, et al. Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood. PMID 28057640 DOI: 10.1182/Blood-2016-07-728253  0.314
2017 Tomaiuolo M, Brass LF, Stalker TJ. Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interventional Cardiology Clinics. 6: 1-12. PMID 27886814 DOI: 10.1016/J.Iccl.2016.08.001  0.475
2016 Brass LF, Diamond SL, Stalker TJ. Platelets and hemostasis: a new perspective on an old subject. Blood Advances. 1: 5-9. PMID 29296690 DOI: 10.1182/Bloodadvances.2016000059  0.351
2016 Welsh JD, Poventud-Fuentes I, Sampietro S, Diamond SL, Stalker TJ, Brass LF. Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. Journal of Thrombosis and Haemostasis : Jth. PMID 27992950 DOI: 10.1111/Jth.13600  0.445
2016 Chen T, Xu DZ, Li Q, Mou P, Zeng Z, Brass LF, Zhu L. The regulation of Sema4D exodomain shedding by protein kinase A in platelets. Platelets. 27: 673-679. PMID 27809714 DOI: 10.3109/09537104.2016.1154141  0.504
2016 Brass LF, Diamond SL. Transport physics and biorheology in the setting of haemostasis and thrombosis. Journal of Thrombosis and Haemostasis : Jth. PMID 26848552 DOI: 10.1111/Jth.13280  0.444
2016 Welsh JD, Muthard RW, Stalker TJ, Taliaferro JP, Diamond SL, Brass LF. A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature. Blood. PMID 26738537 DOI: 10.1182/Blood-2015-09-672188  0.49
2016 Zhu S, Welsh JD, Brass LF, Diamond SL. Platelet-targeting thiol reduction sensor detects thiol isomerase activity on activated platelets in mouse and human blood under flow. Journal of Thrombosis and Haemostasis : Jth. PMID 26725377 DOI: 10.1111/Jth.13245  0.493
2015 Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF. Modulating platelet reactivity through control of RGS18 availability. Blood. PMID 26407691 DOI: 10.1182/Blood-2015-04-640037  0.57
2015 Ma P, Foote DC, Sinnamon AJ, Brass LF. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). Plos One. 10: e0119496. PMID 25785436 DOI: 10.1371/Journal.Pone.0119496  0.487
2015 Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS. Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood. 125: 1623-32. PMID 25477496 DOI: 10.1182/Blood-2014-07-586727  0.4
2014 Stalker TJ, Welsh JD, Brass LF. Shaping the platelet response to vascular injury. Current Opinion in Hematology. 21: 410-7. PMID 25023471 DOI: 10.1097/Moh.0000000000000070  0.479
2014 Stalker TJ, Welsh JD, Tomaiuolo M, Wu J, Colace TV, Diamond SL, Brass LF. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood. 124: 1824-31. PMID 24951426 DOI: 10.1182/Blood-2014-01-550319  0.511
2014 Tomaiuolo M, Stalker TJ, Welsh JD, Diamond SL, Sinno T, Brass LF. A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood. 124: 1816-23. PMID 24951425 DOI: 10.1182/Blood-2014-01-550343  0.487
2014 Welsh JD, Stalker TJ, Voronov R, Muthard RW, Tomaiuolo M, Diamond SL, Brass LF. A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood. 124: 1808-15. PMID 24951424 DOI: 10.1182/Blood-2014-01-550335  0.499
2014 Stalker TJ, Wu J, Brass LF. Platelet Expression of a Genetically Encoded Calcium Indicator Reveals Platelet Activation Gradients in Real Time during Thrombus Formation in Vivo Blood. 124: 96-96. DOI: 10.1182/Blood.V124.21.96.96  0.512
2014 Welsh JD, Taliaferro JP, Stalker TJ, Diamond SL, Brass LF. Thrombus Structure Regulates Plasma Loss after Vascular Injury in Vivo Blood. 124: 4162-4162. DOI: 10.1182/Blood.V124.21.4162.4162  0.465
2013 Wannemacher KM, Jiang H, Hess PR, Shin Y, Suzuki-Inoue K, Brass LF. An expanded role for semaphorin 4D in platelets includes contact-dependent amplification of Clec-2 signaling. Journal of Thrombosis and Haemostasis : Jth. 11: 2190-3. PMID 24131822 DOI: 10.1111/Jth.12428  0.594
2013 Lu Q, Dong N, Wang Q, Yi W, Wang Y, Zhang S, Gu H, Zhao X, Tang X, Jin B, Wu Q, Brass LF, Zhu L. Increased levels of plasma soluble Sema4D in patients with heart failure. Plos One. 8: e64265. PMID 23741311 DOI: 10.1371/Journal.Pone.0064265  0.314
2013 Brass LF, Tomaiuolo M, Stalker TJ. Harnessing the platelet signaling network to produce an optimal hemostatic response. Hematology/Oncology Clinics of North America. 27: 381-409. PMID 23714305 DOI: 10.1016/J.Hoc.2013.02.002  0.575
2013 Mou P, Zeng Z, Li Q, Liu X, Xin X, Wannemacher KM, Ruan C, Li R, Brass LF, Zhu L. Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets. Blood. 121: 4221-30. PMID 23564909 DOI: 10.1182/Blood-2012-11-470609  0.487
2013 Stalker TJ, Traxler EA, Wu J, Wannemacher KM, Cermignano SL, Voronov R, Diamond SL, Brass LF. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood. 121: 1875-85. PMID 23303817 DOI: 10.1182/Blood-2012-09-457739  0.494
2012 Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. Journal of Thrombosis and Haemostasis : Jth. 10: 2344-53. PMID 22978514 DOI: 10.1111/J.1538-7836.2012.04928.X  0.403
2012 Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LF. Platelet signaling. Handbook of Experimental Pharmacology. 59-85. PMID 22918727 DOI: 10.1007/978-3-642-29423-5_3  0.459
2012 Brass LF, Stalker TJ. Minding the gaps--and the junctions, too. Circulation. 125: 2414-6. PMID 22528525 DOI: 10.1161/Circulationaha.112.106377  0.465
2012 Flamm MH, Colace TV, Chatterjee MS, Jing H, Zhou S, Jaeger D, Brass LF, Sinno T, Diamond SL. Multiscale prediction of patient-specific platelet function under flow. Blood. 120: 190-8. PMID 22517902 DOI: 10.1182/Blood-2011-10-388140  0.484
2012 Brass LF, Ma P. Applying the brakes to platelet activation Blood. 119: 3651-3652. PMID 22517872 DOI: 10.1182/Blood-2012-02-406629  0.525
2012 Lee D, Fong KP, King MR, Brass LF, Hammer DA. Differential dynamics of platelet contact and spreading. Biophysical Journal. 102: 472-82. PMID 22325269 DOI: 10.1016/J.Bpj.2011.10.056  0.548
2012 Naik MU, Stalker TJ, Brass LF, Naik UP. JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets. Blood. 119: 3352-60. PMID 22271446 DOI: 10.1182/Blood-2011-12-397398  0.556
2012 Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 119: 1935-45. PMID 22210881 DOI: 10.1182/Blood-2011-10-387910  0.548
2011 Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood. 118: 3661-9. PMID 21816834 DOI: 10.1182/Blood-2011-02-338244  0.47
2011 Brass LF, Wannemacher KM, Ma P, Stalker TJ. Regulating thrombus growth and stability to achieve an optimal response to injury. Journal of Thrombosis and Haemostasis. 9: 66-75. PMID 21781243 DOI: 10.1111/J.1538-7836.2011.04364.X  0.541
2011 Wannemacher KM, Wang L, Zhu L, Brass LF. The role of semaphorins and their receptors in platelets: Lessons learned from neuronal and immune synapses. Platelets. 22: 461-5. PMID 21668292 DOI: 10.3109/09537104.2011.561891  0.466
2011 Heemskerk JW, Sakariassen KS, Zwaginga JJ, Brass LF, Jackson SP, Farndale RW. Collagen surfaces to measure thrombus formation under flow: possibilities for standardization. Journal of Thrombosis and Haemostasis : Jth. 9: 856-8. PMID 21595091 DOI: 10.1111/J.1538-7836.2011.04230.X  0.35
2011 Fong KP, Barry C, Tran AN, Traxler EA, Wannemacher KM, Tang HY, Speicher KD, Blair IA, Speicher DW, Grosser T, Brass LF. Deciphering the human platelet sheddome Blood. 117: e15-e26. PMID 20962327 DOI: 10.1182/Blood-2010-05-283838  0.478
2011 Mou P, Zeng Z, Ren L, Li Q, Wannemacher KM, Mo X, Brass LF, Zhu L. Identification of a Region within the Cytoplasmic Domain of Sema4D That Binds Calmodulin and Regulates Shedding of the Sema4D Exodomain in Platelets Blood. 118: 3249-3249. DOI: 10.1182/Blood.V118.21.3249.3249  0.537
2010 Brass L. Understanding and Evaluating Platelet Function Hematology. 2010: 387-396. PMID 21239824 DOI: 10.1182/Asheducation-2010.1.387  0.526
2010 Wannemacher KM, Zhu L, Jiang H, Fong KP, Stalker TJ, Lee D, Tran AN, Neeves KB, Maloney S, Kumanogoh A, Kikutani H, Hammer DA, Diamond SL, Brass LF. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 116: 5707-15. PMID 20855865 DOI: 10.1182/Blood-2010-04-279943  0.563
2010 Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 116: 6092-100. PMID 20852125 DOI: 10.1182/Blood-2010-05-283846  0.553
2010 Chatterjee MS, Purvis JE, Brass LF, Diamond SL. Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli. Nature Biotechnology. 28: 727-32. PMID 20562863 DOI: 10.1038/Nbt.1642  0.339
2010 Maloney SF, Brass LF, Diamond SL. P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 183-92. PMID 20473398 DOI: 10.1039/B919728A  0.415
2010 Sinnamon A, Ma P, Brass LF. Agonist-Induced Binding of the Regulatory Scaffold Protein Spinophilin to Protein Phosphatase-1 In Platelets Blood. 116: 2029-2029. DOI: 10.1182/Blood.V116.21.2029.2029  0.56
2010 Stalker TJ, Traxler EA, Diamond SL, Brass LF. Development of a Stable Thrombotic Core with Limited Access to Plasma Proteins During Thrombus Formation In Vivo Blood. 116: 2013-2013. DOI: 10.1182/Blood.V116.21.2013.2013  0.507
2010 Ma P, Cierniewska A, Signarvic R, Sinnamon A, Cieslak M, Stalker TJ, Brass LF. Discovery of a New Signaling Complex Based on Spinophilin That Regulates Platelet Activation In Vitro and In Vivo Blood. 116: 161-161. DOI: 10.1182/Blood.V116.21.161.161  0.574
2009 Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proceedings of the National Academy of Sciences of the United States of America. 106: 21167-72. PMID 19940238 DOI: 10.1073/Pnas.0906436106  0.513
2009 Brass L. In the shadow of the thrombus Nature Medicine. 15: 607-608. PMID 19498369 DOI: 10.1038/Nm0609-607  0.449
2009 Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, Lee EK, Neeves KB, Maloney SF, Kikutani H, Kumanogoh A, Pure E, Diamond SL, Brass LF. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1039-45. PMID 19390055 DOI: 10.1161/Atvbaha.109.185405  0.529
2009 Zhang L, Brass LF, Manning DR. The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Molecular Pharmacology. 75: 235-41. PMID 18952767 DOI: 10.1124/Mol.108.050906  0.335
2009 Wang Y, Suzuki A, Lian L, Litvinov RI, Stalker TJ, Choi JK, Weisel JW, Brass LF, Abrams CS. Platelets Lacking PIP5KIγ Have Impaired Cytoskeletal Dynamics and Adhesion, but No Defect in Integrin Activation. Blood. 114: 772-772. DOI: 10.1182/Blood.V114.22.772.772  0.525
2009 Zhu L, Wang T, Jiang H, Stalker TJ, Fong KP, Gruber PJ, Brass LF. Deletion of the Semaphorin, Sema4D, but Not Inhibition of Sema4D Shedding by ADAM17, Impairs Platelet Function and Reduces Infarct Size After Myocardial Ischemia. Blood. 114: 771-771. DOI: 10.1182/Blood.V114.22.771.771  0.496
2009 Naik MU, Stalker TJ, Brass LF, Naik UP. Platelet Junctional Adhesion Molecule-A Regulates Thrombosis by Negatively Regulating Outside-in Signaling through Integrin αIIbβ3. Blood. 114: 155-155. DOI: 10.1182/Blood.V114.22.155.155  0.54
2008 Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14064-9. PMID 18772378 DOI: 10.1073/Pnas.0804139105  0.55
2008 Bezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA. Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. The Journal of Experimental Medicine. 205: 1775-88. PMID 18663126 DOI: 10.1084/Jem.20080240  0.443
2008 Purvis JE, Chatterjee MS, Brass LF, Diamond SL. A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. Blood. 112: 4069-79. PMID 18596227 DOI: 10.1182/Blood-2008-05-157883  0.503
2008 Brass LF, Zhu L, Stalker TJ. Novel therapeutic targets at the platelet vascular interface. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: s43-50. PMID 18174448 DOI: 10.1161/Atvbaha.107.161026  0.535
2008 Schuepbach RA, Feistritzer C, Brass LF, Riewald M. Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood. 111: 2667-73. PMID 18089851 DOI: 10.1182/Blood-2007-09-113076  0.393
2008 Naik MU, Stalker TJ, Brass LF, Naik UP. Junctional Adhesion Molecule a Helps Maintain Integrin αIIbβ3 in Resting State Blood. 112: 111-111. DOI: 10.1182/Blood.V112.11.111.111  0.576
2008 Wang Y, Lian L, Suzuki A, Litvinov RI, Stalker TJ, Schmaier AA, Brass LF, Weisel J, Abrams CS. Loss of Individual PIP5KI Isoforms Demonstrate That Spatial PIP2 Synthesis Is Required for Platelet Second Messenger Formation & Integrity of the Actin Cytoskeleton Blood. 112: 109-109. DOI: 10.1182/Blood.V112.11.109.109  0.532
2007 Kahner BN, Dorsam RT, Mada SR, Kim S, Stalker TJ, Brass LF, Daniel JL, Kitamura D, Kunapuli SP. Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood. 110: 2449-56. PMID 17579181 DOI: 10.1182/Blood-2006-11-056069  0.54
2007 Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proceedings of the National Academy of Sciences of the United States of America. 104: 1621-6. PMID 17244710 DOI: 10.1073/Pnas.0606344104  0.549
2007 Zhu L, Jiang H, Kumanogoh A, Kikutani H, Brass LF. Defective Activation of Phospholipase Cγ2 by Collagen in Platelets Lacking the Semaphorin Family Member, Sema4D. Blood. 110: 417-417. DOI: 10.1182/Blood.V110.11.417.417  0.554
2007 Zhu L, Stalker TJ, Wang T, Jiang H, Kumanogoh A, Kikutani H, Gruber P, Brass LF. Loss of Sema4D Signaling in Platelets Impairs the Formation and Stability of Arterial Thrombi In Vivo and Reduces Myocardial Infarct Size. Blood. 110: 3631-3631. DOI: 10.1182/Blood.V110.11.3631.3631  0.459
2007 Naik M, Stalker T, Brass L, Naik U. JUNCTIONAL ADHESION MOLECULE A (JAM-A) NEGATIVELY REGULATES AGONIST-INDUCED PLATELET ACTIVATION Journal of Thrombosis and Haemostasis. 5: O-M-073-O-M-073. DOI: 10.1111/J.1538-7836.2007.Tb00899.X  0.474
2006 Brass LF, Jiang H, Wu J, Stalker TJ, Zhu L. Contact-dependent signaling events that promote thrombus formation. Blood Cells, Molecules & Diseases. 36: 157-61. PMID 16473534 DOI: 10.1016/J.Bcmd.2005.12.015  0.538
2006 Chen X, Wang Y, Williamson EK, Stalker TJ, Brass LF, Birnbaum MJ, Harwig JH, Abrams CS. Loss of PIP5KIβ Causes a Defect in Lamellipodia Formation and Shear Resistant Adhesion. Blood. 108: 141-141. DOI: 10.1182/Blood.V108.11.141.141  0.445
2006 Brass LF. Thrombus formation: stability matters Blood. 108: 2883-2884. DOI: 10.1182/Blood-2006-08-040857  0.422
2005 Brass LF, Zhu L, Stalker TJ. Minding the gaps to promote thrombus growth and stability. The Journal of Clinical Investigation. 115: 3385-92. PMID 16322784 DOI: 10.1172/Jci26869  0.506
2005 Brass LF. Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors. The Journal of Clinical Investigation. 115: 3329-31. PMID 16322776 DOI: 10.1172/Jci27111  0.473
2005 Prévost N, Woulfe DS, Jiang H, Stalker TJ, Marchese P, Ruggeri ZM, Brass LF. Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proceedings of the National Academy of Sciences of the United States of America. 102: 9820-5. PMID 15994237 DOI: 10.1073/Pnas.0404065102  0.547
2005 Tong MH, Jiang H, Liu P, Lawson JA, Brass LF, Song WC. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nature Medicine. 11: 153-9. PMID 15685171 DOI: 10.1038/Nm1184  0.329
2005 Zhu L, Bergmeier W, Wu J, Jiang H, Yeboah N, Fan R, Cieslak M, Milla ME, Brass LF. Regulated Shedding of sema4D from the Platelet Surface Produces a Bioactive Second Messenger in Thrombotic Disorders. Blood. 106: 1641-1641. DOI: 10.1182/Blood.V106.11.1641.1641  0.572
2004 Brass LF, Stalker TJ, Zhu L, Lu B, Woulfe DS, Prevost N. Boundary events: contact-dependent and contact-facilitated signaling between platelets. Seminars in Thrombosis and Hemostasis. 30: 399-410. PMID 15354261 DOI: 10.1055/S-2004-833475  0.527
2004 Woulfe D, Yang J, Prevost N, O'Brien P, Fortna R, Tognolini M, Jiang H, Wu J, Brass LF. Signaling receptors on platelets and megakaryocytes. Methods in Molecular Biology (Clifton, N.J.). 273: 3-32. PMID 15308791 DOI: 10.1385/1-59259-783-1:003  0.496
2004 Brass L. Fifty (or More) Ways to Leave Your Platelets (in a Thrombus) Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 989-991. PMID 15178570 DOI: 10.1161/01.Atv.0000131781.98156.Da  0.542
2004 Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. The Journal of Clinical Investigation. 113: 441-50. PMID 14755341 DOI: 10.1172/Jci20267  0.53
2004 Prévost N, Woulfe DS, Tognolini M, Tanaka T, Jian W, Fortna RR, Jiang H, Brass LF. Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1. Blood. 103: 1348-55. PMID 14576067 DOI: 10.1182/Blood-2003-06-1781  0.521
2003 O'Brien PJ, Koi H, Parry S, Brass LF, Strauss JF, Wang LP, Tomaszewski JE, Christenson LK. Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro. The American Journal of Pathology. 163: 1245-54. PMID 14507634 DOI: 10.1016/S0002-9440(10)63484-0  0.377
2003 Brass LF. Thrombin and platelet activation. Chest. 124: 18S-25S. PMID 12970120 DOI: 10.1378/Chest.124.3_Suppl.18S  0.57
2003 Prevost N, Woulfe D, Tognolini M, Brass LF. Contact-dependent signaling during the late events of platelet activation. Journal of Thrombosis and Haemostasis. 1: 1613-1627. PMID 12871298 DOI: 10.1046/J.1538-7836.2003.00327.X  0.525
2003 Brass LF. ATVB in focus: Platelet signal transduction and interactions with vascular cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 378. PMID 12639828 DOI: 10.1161/01.Atv.0000060448.57425.05  0.484
2002 Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR, Woulfe D, Brass LF. Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. The Journal of Biological Chemistry. 277: 46035-42. PMID 12297509 DOI: 10.1074/Jbc.M208519200  0.436
2002 Prevost N, Woulfe D, Tanaka T, Brass LF. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proceedings of the National Academy of Sciences of the United States of America. 99: 9219-24. PMID 12084815 DOI: 10.1073/Pnas.142053899  0.528
2002 Woulfe D, Jiang H, Mortensen R, Yang J, Brass LF. Activation of Rap1B by G(i) family members in platelets. The Journal of Biological Chemistry. 277: 23382-90. PMID 11970953 DOI: 10.1074/Jbc.M202212200  0.484
2001 Brass L. VWF meets the ADAMTS family. Nature Medicine. 7: 1177-1178. PMID 11689874 DOI: 10.1038/Nm1101-1177  0.38
2001 Woulfe D, Yang J, Brass L. ADP and platelets: the end of the beginning Journal of Clinical Investigation. 107: 1503-1505. PMID 11413156 DOI: 10.1172/Jci13361  0.58
2001 Riewald M, Kravchenko VV, Petrovan RJ, O'Brien PJ, Brass LF, Ulevitch RJ, Ruf W. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood. 97: 3109-3116. PMID 11342437 DOI: 10.1182/Blood.V97.10.3109  0.408
2001 O'Brien PJ, Molino M, Kahn M, Brass LF. Protease activated receptors: Theme and variations Oncogene. 20: 1570-1581. PMID 11313904 DOI: 10.1038/Sj.Onc.1204194  0.377
2001 Cumashi A, Ansuini H, Celli N, Blasi AD, O’Brien PJ, Brass LF, Molino M. Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. Thrombosis and Haemostasis. 85: 533-538. DOI: 10.1055/S-0037-1615617  0.507
2000 Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proceedings of the National Academy of Sciences of the United States of America. 97: 9984-9. PMID 10954748 DOI: 10.1073/Pnas.180194597  0.437
2000 Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. The Journal of Biological Chemistry. 275: 32129-34. PMID 10906137 DOI: 10.1074/Jbc.M004577200  0.325
2000 Molino M, Woolkalis MJ, Prevost N, Praticó D, Barnathan ES, Taraboletti G, Haggarty BS, Hesselgesser J, Horuk R, Hoxie JA, Brass LF. CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2 Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1500: 227-240. PMID 10657592 DOI: 10.1016/S0925-4439(99)00110-6  0.346
2000 Kowalska MA, Ratajczak MZ, Majka M, Jin J, Kunapuli S, Brass L, Poncz M. Stromal cell–derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets Blood. 96: 50-57. DOI: 10.1182/Blood.V96.1.50.013K40_50_57  0.571
1999 Brass LF. More pieces of the platelet activation puzzle slide into place. Journal of Clinical Investigation. 104: 1663-1665. PMID 10606617 DOI: 10.1172/Jci8944  0.584
1999 Cichowski K, Orsini MJ, Brass LF. PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells. Biochimica Et Biophysica Acta. 1450: 265-276. PMID 10395938 DOI: 10.1016/S0167-4889(99)00065-8  0.503
1999 Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, Hoxie JA, Peiper SC, Brass LF, Doms RW. Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. Journal of Virology. 73: 2752-61. PMID 10074122 DOI: 10.1128/Jvi.73.4.2752-2761.1999  0.354
1999 Kowalska MA, Ratajczak J, Hoxie J, Brass LF, Gewirtz A, Poncz M, Ratajczak MZ. Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: Determination of response to stromal- derived factor-1 by megakaryocytes and platelets British Journal of Haematology. 104: 220-229. PMID 10050701 DOI: 10.1046/J.1365-2141.1999.01169.X  0.528
1998 Weinstein JR, Lau AL, Brass LF, Cunningham DD. Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. Journal of Neurochemistry. 71: 1034-50. PMID 9721728 DOI: 10.1046/J.1471-4159.1998.71031034.X  0.393
1998 Schechter NM, Brass LF, Lavker RM, Jensen PJ. Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts. Journal of Cellular Physiology. 176: 365-73. PMID 9648924 DOI: 10.1002/(Sici)1097-4652(199808)176:2<365::Aid-Jcp15>3.0.Co;2-2  0.383
1998 Johnson EN, Brass LF, Funk CD. Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America. 95: 3100-5. PMID 9501222 DOI: 10.1073/Pnas.95.6.3100  0.482
1997 Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. The Journal of Cell Biology. 139: 651-64. PMID 9348282 DOI: 10.1083/Jcb.139.3.651  0.327
1997 Brass LF, Manning DR, Cichowski K, Abrams CS. Signaling through G proteins in platelets: To the integrins and beyond Thrombosis and Haemostasis. 78: 581-589. PMID 9198220 DOI: 10.1055/S-0038-1657593  0.515
1997 Molino M, Woolkalis MJ, Reavey-Cantwell J, Praticó D, Andrade-Gordon P, Barnathan ES, Brass LF. Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment Journal of Biological Chemistry. 272: 11133-11141. PMID 9111010 DOI: 10.1074/Jbc.272.17.11133  0.409
1997 Brass LF. Thrombin receptor antagonists: a work in progress. Coronary Artery Disease. 8: 49-58. PMID 9101123 DOI: 10.1097/00019501-199701000-00008  0.413
1997 Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. The Journal of Biological Chemistry. 272: 6011-7. PMID 9038223 DOI: 10.1074/Jbc.272.9.6011  0.544
1997 Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. Interactions of mast cell tryptase with thrombin receptors and PAR-2 Journal of Biological Chemistry. 272: 4043-4049. PMID 9020112 DOI: 10.1074/Jbc.272.7.4043  0.443
1997 Barr AJ, Brass LF, Manning DR. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling Journal of Biological Chemistry. 272: 2223-2229. PMID 8999927 DOI: 10.1074/Jbc.272.4.2223  0.335
1997 Brass LF, Molino M. Protease-activated G protein-coupled receptors on human platelets and endothelial cells. Thrombosis and Haemostasis. 78: 234-241. DOI: 10.1055/S-0038-1657532  0.485
1997 Brass LF, Poncz M, Manning DR. G Proteins and the Early Events of Platelet Activation Advances in Molecular and Cell Biology. 18: 179-195. DOI: 10.1016/S1569-2558(08)60415-4  0.459
1996 Abrams CS, Zhao W, Brass LF. A site of interaction between pleckstrin's PH domains and Gβγ Biochimica Et Biophysica Acta. 1314: 233-238. PMID 8982277 DOI: 10.1016/S0167-4889(96)00109-7  0.303
1996 Cichowski K, Brugge JS, Brass LF. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets Journal of Biological Chemistry. 271: 7544-7550. PMID 8631786 DOI: 10.1074/Jbc.271.13.7544  0.538
1995 Zacharias U, He C, Hagège J, Xu Y, Sraer J, Brass LF, Rondeau E. Thrombin and phorbol ester induce internalization of thrombin receptor of human mesangial cells through different pathways. Experimental Cell Research. 216: 371-379. PMID 7843281 DOI: 10.1006/Excr.1995.1047  0.411
1995 Tordai A, Brass LF, Gelfand EW. Tunicamycin inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Biochemical and Biophysical Research Communications. 206: 857-862. PMID 7832797 DOI: 10.1006/Bbrc.1995.1122  0.358
1995 Zacharias U, Xu Y, Hagège J, Sraer J, Brass LF, Rondeau E. Thrombin, Phorbol Ester, and cAMP Regulate Thrombin Receptor Protein and mRNA Expression by Different Pathways Journal of Biological Chemistry. 270: 545-550. PMID 7822278 DOI: 10.1074/Jbc.270.2.545  0.392
1995 Abrams CS, Wu H, Zhao W, Belmonte E, White D, Brass LF. Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains. Journal of Biological Chemistry. 270: 14485-14492. PMID 7782310 DOI: 10.1074/Jbc.270.24.14485  0.331
1995 Molino M, Blanchard N, Belmonte E, Tarver AP, Abrams C, Hoxie JA, Cerletti C, Brass LF. Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G Journal of Biological Chemistry. 270: 11168-11175. PMID 7744748 DOI: 10.1074/Jbc.270.19.11168  0.439
1995 Woolkalis MJ, DeMelfi TM, Blanchard N, Hoxie JA, Brass LF. Regulation of thrombin receptors on human umbilical vein endothelial cells Journal of Biological Chemistry. 270: 9868-9875. PMID 7730369 DOI: 10.1074/Jbc.270.17.9868  0.373
1995 Abrams CS, Zhao W, Belmonte E, Brass LF. Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain Journal of Biological Chemistry. 270: 23317-23321. PMID 7559487 DOI: 10.1074/Jbc.270.40.23317  0.326
1995 Brass LF. Issues in the development of thrombin receptor antagonists. Thrombosis and Haemostasis. 74: 499-505. DOI: 10.1055/S-0038-1642728  0.458
1995 Brass LF, Woolkalis MJ, Hoxie JA. Trafficking thrombin receptors. Biodiversity on the receptor superhighway Trends in Cardiovascular Medicine. 5: 123-128. DOI: 10.1016/1050-1738(95)00051-A  0.402
1994 Brass LF, Ahuja M, Belmonte E, Pizarro S, Tarver A, Hoxie JA. The human platelet thrombin receptor. Turning it on and turning it off Annals of the New York Academy of Sciences. 714: 1-12. PMID 8017757 DOI: 10.1111/J.1749-6632.1994.Tb12025.X  0.499
1993 Brass LF, Hoxie JA, Manning DR. Signaling through G proteins and G protein-coupled receptors during platelet activation Thrombosis and Haemostasis. 70: 217-223. PMID 8236108 DOI: 10.1055/S-0038-1646194  0.527
1993 Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis M. Agonist receptors and G proteins as mediators of platelet activation Advances in Experimental Medicine and Biology. 344: 17-36. PMID 8209785 DOI: 10.1007/978-1-4615-2994-1_2  0.563
1991 Manning DR, Brass LF. The role of GTP-binding proteins in platelet activation Thrombosis and Haemostasis. 66: 393-399. PMID 1665593 DOI: 10.1055/S-0038-1646426  0.496
1991 Gagnon A, Manning D, Catani L, Gewirtz A, Poncz M, Brass L. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes Blood. 78: 1247-1253. DOI: 10.1182/Blood.V78.5.1247.1247  0.385
1991 Suldan Z, Brass L. Role of the glycoprotein IIb-IIIa complex in plasma membrane Ca2+ transport: a comparison of results obtained with platelets and human erythroleukemia cells Blood. 78: 2887-2893. DOI: 10.1182/Blood.V78.11.2887.Bloodjournal78112887  0.4
1991 Brass LF, Manning DR. G proteins and low-molecular-weight GTP-binding proteins in platelets Trends in Cardiovascular Medicine. 1: 92-98. DOI: 10.1016/1050-1738(91)90017-9  0.454
1989 Brass LF, Belmonte E. [32] Calcium-45 exchange techniques to study calcium transport in intact platelets Methods in Enzymology. 169: 371-385. PMID 2654567 DOI: 10.1016/0076-6879(89)69076-3  0.389
1989 Brass LF, Shattil SJ. [31] Interaction of extracellular calcium with the surface membrane of human platelets Methods in Enzymology. 169: 355-371. PMID 2654565 DOI: 10.1016/0076-6879(89)69075-1  0.369
1987 Brass LF, Laposata M. Diacylglycerol causes Ca release from the platelet dense tubular system: comparisons with Ca release caused by inositol 1,4,5-triphosphate☆ Biochemical and Biophysical Research Communications. 142: 7-14. PMID 3493001 DOI: 10.1016/0006-291X(87)90444-X  0.34
1986 Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 68: 1224-31. PMID 3779100 DOI: 10.1182/Blood.V68.6.1224.1224  0.559
1986 Banga HS, Simons ER, Brass LF, Rittenhouse SE. Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine. Proceedings of the National Academy of Sciences of the United States of America. 83: 9197-9201. PMID 3024170 DOI: 10.1073/Pnas.83.23.9197  0.448
1985 Shattil S, Brass L, Bennett J, Pandhi P. Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex Blood. 66: 92-98. DOI: 10.1182/Blood.V66.1.92.92  0.497
1984 Brass LF, Shattil SJ. Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets. Journal of Clinical Investigation. 73: 626-632. PMID 6231306 DOI: 10.1172/Jci111252  0.457
1974 Brass LF, Bensusan HB. The Role of Collagen Quaternary Structure in the Platelet:Collagen Interaction Journal of Clinical Investigation. 54: 1480-1487. PMID 4215825 DOI: 10.1172/Jci107896  0.446
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