| Year |
Citation |
Score |
| 2015 |
Wenzlau JM, Fain PR, Gardner TJ, Frisch LM, Annibale B, Hutton JC. ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study. Diabetes Care. 38: S29-36. PMID 26405069 DOI: 10.2337/Dcs15-2006 |
0.375 |
|
| 2015 |
Wenzlau JM, Frisch LM, Hutton JC, Fain PR, Davidson HW. Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop. Diabetes Care. 38: S14-20. PMID 26405067 DOI: 10.2337/Dcs15-2004 |
0.362 |
|
| 2015 |
Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW, Pugliese A. Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26317167 DOI: 10.1111/Ajt.13426 |
0.301 |
|
| 2015 |
Brorsson CA, Onengut S, Chen WM, Wenzlau J, Yu L, Baker P, Williams AJ, Bingley PJ, Hutton JC, Eisenbarth GS, Concannon P, Rich SS, Pociot F. Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes. Diabetes. PMID 25829454 DOI: 10.2337/Db14-1730 |
0.37 |
|
| 2014 |
Asanghanwa M, Gorus FK, Weets I, der Auwera BV, Aminkeng F, Mbunwe E, Goubert P, Verhaeghen K, Sobngwi E, Wenzlau JM, Hutton JC, Pipeleers DG, Keymeulen B, Mbanya JC, van Schravendijk C. Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients. Diabetes Research and Clinical Practice. 103: 97-105. PMID 24332797 DOI: 10.1016/J.Diabres.2013.11.013 |
0.338 |
|
| 2013 |
Wenzlau JM, Hutton JC. Novel diabetes autoantibodies and prediction of type 1 diabetes. Current Diabetes Reports. 13: 608-15. PMID 23900975 DOI: 10.1007/S11892-013-0405-9 |
0.374 |
|
| 2013 |
Mbunwe E, Auwera BJVd, Weets I, Crombrugge PV, Crenier L, Coeckelberghs M, Seret N, Decochez K, Vandemeulebroucke E, Gillard P, Keymeulen B, Schravendijk Cv, Wenzlau JM, Hutton JC, Pipeleers DG, et al. In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions Diabetologia. 56: 1964-1970. PMID 23712485 DOI: 10.1007/S00125-013-2951-8 |
0.363 |
|
| 2013 |
Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM. G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes. 62: 1547-56. PMID 23274894 DOI: 10.2337/Db12-1067 |
0.381 |
|
| 2013 |
Gorus FK, Balti EV, Vermeulen I, Demeester S, Van Dalem A, Costa O, Dorchy H, Tenoutasse S, Mouraux T, De Block C, Gillard P, Decochez K, Wenzlau JM, Hutton JC, Pipeleers DG, et al. Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clinical and Experimental Immunology. 171: 82-90. PMID 23199327 DOI: 10.1111/J.1365-2249.2012.04675.X |
0.356 |
|
| 2013 |
Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, et al. HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients. Diabetes. 62: 1345-50. PMID 23160529 DOI: 10.2337/Db12-0747 |
0.356 |
|
| 2013 |
Yang T, Hohenstein AC, Lee CE, Hutton JC, Davidson HW. Mapping I-A(g7) restricted epitopes in murine G6PC2. Immunologic Research. 55: 91-9. PMID 22983906 DOI: 10.1007/S12026-012-8368-5 |
0.4 |
|
| 2012 |
Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. Plos One. 7: e40972. PMID 22829903 DOI: 10.1371/Journal.Pone.0040972 |
0.364 |
|
| 2012 |
Baker P, Fain P, Kahles H, Yu L, Hutton J, Wenzlau J, Rewers M, Badenhoop K, Eisenbarth G. Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium. The Journal of Clinical Endocrinology and Metabolism. 97: E1573-8. PMID 22723331 DOI: 10.1210/Jc.2011-2824 |
0.349 |
|
| 2012 |
Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, et al. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia. 55: 2026-31. PMID 22526607 DOI: 10.1007/S00125-012-2543-Z |
0.364 |
|
| 2012 |
Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL. Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care. 35: 1213-8. PMID 22446173 DOI: 10.2337/Dc11-2081 |
0.4 |
|
| 2012 |
Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M, Snieder H, Boehm BO, Leslie RD. Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes. 61: 1192-8. PMID 22396204 DOI: 10.2337/Db11-0971 |
0.394 |
|
| 2012 |
Wu X, Xu X, Gu R, Wang Z, Chen H, Xu K, Zhang M, Hutton J, Yang T. Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays. Autoimmunity. 45: 176-85. PMID 22260783 DOI: 10.3109/08916934.2011.622014 |
0.34 |
|
| 2012 |
Vermeulen I, Weets I, Costa O, Asanghanwa M, Verhaeghen K, Decochez K, Ruige J, Casteels K, Wenzlau J, Hutton JC, Pipeleers DG, Gorus FK. An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age. Diabetologia. 55: 413-420. PMID 22095238 DOI: 10.1007/S00125-011-2376-1 |
0.347 |
|
| 2012 |
Yang H, Wang Z, Xu K, Gu R, Chen H, Yu D, Xing C, Liu Y, Yu L, Hutton J, Eisenbarth G, Yang T. IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population. Autoimmunity. 45: 226-32. PMID 22053898 DOI: 10.3109/08916934.2011.633134 |
0.327 |
|
| 2011 |
Gu Y, Zhang M, Chen H, Wang Z, Xing C, Yang H, Xu X, Liu Y, Zhou Z, Yu L, Hutton J, Eisenbarth G, Yang T. Discordant association of islet autoantibodies with high-risk HLA genes in Chinese type 1 diabetes. Diabetes/Metabolism Research and Reviews. 27: 899-905. PMID 22069282 DOI: 10.1002/Dmrr.1270 |
0.378 |
|
| 2011 |
Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC. Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals. Diabetes/Metabolism Research and Reviews. 27: 887-90. PMID 22069279 DOI: 10.1002/Dmrr.1267 |
0.342 |
|
| 2011 |
Wenzlau JM, Frisch LM, Hutton JC, Davidson HW. Mapping of conformational autoantibody epitopes in ZNT8. Diabetes/Metabolism Research and Reviews. 27: 883-6. PMID 22069278 DOI: 10.1002/Dmrr.1266 |
0.339 |
|
| 2011 |
Lampasona V, Schlosser M, Mueller PW, Williams AJ, Wenzlau JM, Hutton JC, Achenbach P. Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. Clinical Chemistry. 57: 1693-702. PMID 21980171 DOI: 10.1373/Clinchem.2011.170662 |
0.357 |
|
| 2011 |
Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM. Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice. Diabetes. 60: 2922-7. PMID 21896930 DOI: 10.2337/Db11-0220 |
0.445 |
|
| 2011 |
Pound LD, Sarkar SA, Cauchi S, Wang Y, Oeser JK, Lee CE, Froguel P, Hutton JC, O'Brien RM. Characterization of the human SLC30A8 promoter and intronic enhancer. Journal of Molecular Endocrinology. 47: 251-9. PMID 21798992 DOI: 10.1530/Jme-11-0055 |
0.375 |
|
| 2011 |
Vermeulen I, Weets I, Asanghanwa M, Ruige J, Van Gaal L, Mathieu C, Keymeulen B, Lampasona V, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK. Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care. 34: 1760-5. PMID 21715527 DOI: 10.2337/Dc10-2268 |
0.399 |
|
| 2011 |
Steck AK, Johnson K, Barriga KJ, Miao D, Yu L, Hutton JC, Eisenbarth GS, Rewers MJ. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care. 34: 1397-9. PMID 21562325 DOI: 10.2337/Dc10-2088 |
0.4 |
|
| 2011 |
Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. Journal of Immunology (Baltimore, Md. : 1950). 186: 6056-63. PMID 21471440 DOI: 10.4049/Jimmunol.1003815 |
0.382 |
|
| 2011 |
Pound LD, Hang Y, Sarkar SA, Wang Y, Milam LA, Oeser JK, Printz RL, Lee CE, Stein R, Hutton JC, O'Brien RM. The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. The Biochemical Journal. 433: 95-105. PMID 20942803 DOI: 10.1042/Bj20101488 |
0.419 |
|
| 2010 |
YANG L, LUO SM, HUANG G, PENG J, YAN X, WENZLAU J, DAVIDSON HW, HUTTON JC, ZHOU ZG. [Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics]. Zhonghua Yi Xue Za Zhi. 90: 2536-40. PMID 21092458 DOI: 10.3760/Cma.J.Issn.0376-2491.2010.36.005 |
0.331 |
|
| 2010 |
Stene LC, Oikarinen S, Hyöty H, Barriga KJ, Norris JM, Klingensmith G, Hutton JC, Erlich HA, Eisenbarth GS, Rewers M. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes. 59: 3174-80. PMID 20858685 DOI: 10.2337/Db10-0866 |
0.385 |
|
| 2010 |
Yang L, Luo S, Huang G, Peng J, Li X, Yan X, Lin J, Wenzlau JM, Davidson HW, Hutton JC, Zhou Z. The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes/Metabolism Research and Reviews. 26: 579-84. PMID 20842762 DOI: 10.1002/Dmrr.1128 |
0.372 |
|
| 2010 |
Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. The Journal of Clinical Endocrinology and Metabolism. 95: 4712-9. PMID 20610599 DOI: 10.1210/Jc.2010-0169 |
0.391 |
|
| 2010 |
Hutton JC, Davidson HW. Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes. Diabetes. 59: 335-6. PMID 20103713 DOI: 10.2337/Db09-1767 |
0.346 |
|
| 2010 |
Grijse JD, Asanghanwa M, Nouthe B, Albrecher N, Goubert P, Vermeulen I, Meeren SVD, Decochez K, Weets I, Keymeulen B, Lampasona V, Wenzlau J, Hutton JC, Pipeleers D, Gorus FK. Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials Diabetologia. 53: 517-524. PMID 20091020 DOI: 10.1007/S00125-009-1618-Y |
0.405 |
|
| 2010 |
Yu L, Liu Y, Miao D, Wenzlau J, Davidson H, Hutton J, Eisenbarth GS. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. Journal of Immunological Methods. 353: 20-3. PMID 20035758 DOI: 10.1016/J.Jim.2009.12.004 |
0.407 |
|
| 2009 |
Hutton JC, O'Brien RM. Glucose-6-phosphatase catalytic subunit gene family. The Journal of Biological Chemistry. 284: 29241-5. PMID 19700406 DOI: 10.1074/Jbc.R109.025544 |
0.334 |
|
| 2009 |
Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. The Biochemical Journal. 421: 371-6. PMID 19450229 DOI: 10.1042/Bj20090530 |
0.432 |
|
| 2009 |
Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia. 52: 1092-101. PMID 19343319 DOI: 10.1007/S00125-009-1331-X |
0.326 |
|
| 2009 |
Wenzlau JM, Frisch LM, Gardner TJ, Sarkar S, Hutton JC, Davidson HW. Novel antigens in type 1 diabetes: the importance of ZnT8. Current Diabetes Reports. 9: 105-12. PMID 19323954 DOI: 10.1007/S11892-009-0019-4 |
0.424 |
|
| 2009 |
Hutton JC, Wong R, Davidson HW. Isolation of dense core secretory vesicles from pancreatic endocrine cells by differential and density gradient centrifugation. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 3.32. PMID 19283733 DOI: 10.1002/0471143030.Cb0332S42 |
0.358 |
|
| 2009 |
Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith G. Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. The Journal of Clinical Endocrinology and Metabolism. 94: 504-10. PMID 19050058 DOI: 10.1210/Jc.2007-2694 |
0.409 |
|
| 2008 |
Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC. SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Annals of the New York Academy of Sciences. 1150: 256-9. PMID 19120307 DOI: 10.1196/Annals.1447.029 |
0.424 |
|
| 2008 |
Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW. Identification of a major humoral epitope in Slc30A8 (ZnT8). Annals of the New York Academy of Sciences. 1150: 252-5. PMID 19120306 DOI: 10.1196/Annals.1447.028 |
0.325 |
|
| 2008 |
Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW. Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens Annals of the New York Academy of Sciences. 1150: 245-247. PMID 19120304 DOI: 10.1196/Annals.1447.035 |
0.405 |
|
| 2008 |
Kawasaki E, Uga M, Nakamura KT, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia. 51: 2299-2302. PMID 18850084 DOI: 10.1007/S00125-008-1165-Y |
0.351 |
|
| 2008 |
Quayum N, Kutchma A, Sarkar SA, Juhl K, Gradwohl G, Mellitzer G, Hutton JC, Jensen J. GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist. Experimental Diabetes Research. 2008: 312060. PMID 18795106 DOI: 10.1155/2008/312060 |
0.304 |
|
| 2008 |
Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC. Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes. 57: 2755-61. PMID 18599526 DOI: 10.2337/Db07-1126 |
0.418 |
|
| 2008 |
Wenzlau JM, Hutton JC, Davidson HW. New antigenic targets in type 1 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity. 15: 315-20. PMID 18594270 DOI: 10.1097/Med.0B013E328308192B |
0.423 |
|
| 2008 |
Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes. 57: 2693-7. PMID 18591387 DOI: 10.2337/Db08-0522 |
0.397 |
|
| 2008 |
Burton AR, Vincent E, Arnold PY, Lennon GP, Smeltzer M, Li CS, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DA. On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes. 57: 1321-30. PMID 18299317 DOI: 10.2337/Db07-1129 |
0.418 |
|
| 2008 |
Sarkar SA, Kobberup S, Wong R, Lopez AD, Quayum N, Still T, Kutchma A, Jensen JN, Gianani R, Beattie GM, Jensen J, Hayek A, Hutton JC. Global gene expression profiling and histochemical analysis of the developing human fetal pancreas Diabetologia. 51: 285-297. PMID 18094957 DOI: 10.1007/S00125-007-0880-0 |
0.378 |
|
| 2008 |
Wang Y, Flemming BP, Martin CC, Allen SR, Walters J, Oeser JK, Hutton JC, O'Brien RM. Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo. Diabetes. 57: 133-41. PMID 17942825 DOI: 10.2337/Db07-0092 |
0.358 |
|
| 2007 |
Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 104: 17040-5. PMID 17942684 DOI: 10.1073/Pnas.0705894104 |
0.447 |
|
| 2007 |
Kobberup S, Nyeng P, Juhl K, Hutton J, Jensen J. ETS‐family genes in pancreatic development Developmental Dynamics. 236: 3100-3110. PMID 17907201 DOI: 10.1002/Dvdy.21292 |
0.302 |
|
| 2007 |
Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 50: 1649-59. PMID 17593347 DOI: 10.1007/S00125-007-0707-Z |
0.34 |
|
| 2007 |
Wang Y, Martin CC, Oeser JK, Sarkar S, McGuinness OP, Hutton JC, O'Brien RM. Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype. Diabetologia. 50: 774-8. PMID 17265032 DOI: 10.1007/S00125-006-0564-1 |
0.406 |
|
| 2007 |
Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes. 56: 72-9. PMID 17192467 DOI: 10.2337/Db06-0617 |
0.334 |
|
| 2006 |
Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM. Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon. The Journal of Biological Chemistry. 281: 39982-9. PMID 17023421 DOI: 10.1074/Jbc.M605858200 |
0.327 |
|
| 2006 |
Dogra RS, Vaidyanathan P, Prabakar KR, Marshall KE, Hutton JC, Pugliese A. Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetologia. 49: 953-7. PMID 16520917 DOI: 10.1007/S00125-006-0185-8 |
0.49 |
|
| 2006 |
Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, Beilke J, Supon P, Valentine A, Iveson A, Dunn S, Eisenbarth GS, Hutton J, Gottlieb P, Wiseman A. Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. The Journal of Clinical Endocrinology and Metabolism. 91: 1855-61. PMID 16478822 DOI: 10.1210/Jc.2005-1171 |
0.321 |
|
| 2006 |
Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology. 147: 1488-97. PMID 16339204 DOI: 10.1210/En.2005-0900 |
0.394 |
|
| 2005 |
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature. 435: 220-3. PMID 15889095 DOI: 10.1038/Nature03523 |
0.475 |
|
| 2005 |
Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC. An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin. Traffic (Copenhagen, Denmark). 6: 474-87. PMID 15882444 DOI: 10.1111/J.1600-0854.2005.00292.X |
0.314 |
|
| 2005 |
Limesand SW, Jensen J, Hutton JC, Hay WW. Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1297-305. PMID 15650129 DOI: 10.1152/Ajpregu.00494.2004 |
0.357 |
|
| 2004 |
Nakayama M, Moriyama H, Abiru N, Babu SR, Sikora K, Li M, Miao D, Hutton JC, Elliott JF, Eisenbarth GS. Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene. Annals of the New York Academy of Sciences. 1037: 193-8. PMID 15699516 DOI: 10.1196/Annals.1337.031 |
0.385 |
|
| 2004 |
Vo YP, Hutton JC, Angleson JK. Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. Biochemical and Biophysical Research Communications. 324: 1004-10. PMID 15485654 DOI: 10.1016/J.Bbrc.2004.09.147 |
0.372 |
|
| 2004 |
Frigeri C, Martin CC, Svitek CA, Oeser JK, Hutton JC, Gannon M, O'Brien RM. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes. 53: 1754-64. PMID 15220199 DOI: 10.2337/Diabetes.53.7.1754 |
0.359 |
|
| 2004 |
Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. Journal of Immunology (Baltimore, Md. : 1950). 172: 3955-62. PMID 15004204 DOI: 10.4049/Jimmunol.172.6.3955 |
0.381 |
|
| 2004 |
Boustead J, Martin C, Oeser J, Svitek C, Hunter S, Hutton J, O'Brien R. Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. Journal of Molecular Endocrinology. 32: 33-53. PMID 14765991 DOI: 10.1677/Jme.0.0320033 |
0.34 |
|
| 2003 |
Hutton JC, Eisenbarth GS. A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proceedings of the National Academy of Sciences of the United States of America. 100: 8626-8. PMID 12861077 DOI: 10.1073/Pnas.1633447100 |
0.478 |
|
| 2003 |
Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW. Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. Journal of Proteome Research. 2: 199-205. PMID 12716134 DOI: 10.1021/Pr025576X |
0.345 |
|
| 2003 |
Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S. Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells. The Journal of Biological Chemistry. 278: 23055-65. PMID 12679364 DOI: 10.1074/Jbc.M212450200 |
0.325 |
|
| 2002 |
Guest PC, Abdel-Halim SM, Gross DJ, Clark A, Poitout V, Amaria R, Ostenson CG, Hutton JC. Proinsulin processing in the diabetic Goto-Kakizaki rat. The Journal of Endocrinology. 175: 637-47. PMID 12475375 DOI: 10.1677/Joe.0.1750637 |
0.433 |
|
| 2002 |
Achenbach P, Kelemen K, Wegmann DR, Hutton JC. Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. Journal of Autoimmunity. 19: 111-6. PMID 12419281 DOI: 10.1006/Jaut.2002.0611 |
0.414 |
|
| 2002 |
Martin C, Oeser J, Svitek C, Hunter S, Hutton J, O'Brien R. Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein Journal of Molecular Endocrinology. 29: 205-222. PMID 12370122 DOI: 10.1677/Jme.0.0290205 |
0.337 |
|
| 2002 |
Wasmeier C, Bright NA, Hutton JC. The lumenal domain of the integral membrane protein phogrin mediates targeting to secretory granules. Traffic (Copenhagen, Denmark). 3: 654-65. PMID 12191017 DOI: 10.1034/J.1600-0854.2002.30907.X |
0.306 |
|
| 2001 |
Kelemen K, Wegmann DR, Hutton JC. T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse Diabetes. 50: 1729-1734. PMID 11473031 DOI: 10.2337/Diabetes.50.8.1729 |
0.381 |
|
| 2001 |
Wasmeier C, Hutton JC. Secretagogue-dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP-dependent protein kinase. Journal of Biological Chemistry. 276: 31919-31928. PMID 11353772 DOI: 10.1074/Jbc.M102580200 |
0.345 |
|
| 2001 |
Martin CC, Bischof LJ, Bergman B, Hornbuckle LA, Hilliker C, Frigeri C, Wahl D, Svitek CA, Wong R, Goldman JK, Oeser JK, Leprêtre F, Froguel P, O'Brien RM, Hutton JC. Cloning and Characterization of the Human and Rat Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein (IGRP) Genes Journal of Biological Chemistry. 276: 25197-25207. PMID 11297555 DOI: 10.1074/Jbc.M101549200 |
0.373 |
|
| 2001 |
Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C, Hutton J, Eisenbarth GS, Pugliese A. Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes. 50: 895-900. PMID 11289059 DOI: 10.2337/Diabetes.50.4.895 |
0.457 |
|
| 2001 |
Bischof LJ, Martin CC, Svitek CA, Stadelmaier BT, Hornbuckle LA, Goldman JK, Oeser JK, Hutton JC, O’Brien RM. Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: Correlation with fusion gene expression in the islet-derived βTC-3 and hamster insulinoma tumor cell lines Diabetes. 50: 502-514. PMID 11246869 DOI: 10.2337/Diabetes.50.3.502 |
0.376 |
|
| 2001 |
Norlén P, Curry WJ, Björkqvist M, Maule A, Cunningham RT, Hogg RB, Harriott P, Johnston CF, Hutton JC, Håkanson R. Cell-specific processing of chromogranin A in endocrine cells of the rat stomach. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 49: 9-18. PMID 11118474 DOI: 10.1177/002215540104900102 |
0.325 |
|
| 2001 |
Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC. IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm. The Journal of Comparative Neurology. 429: 127-43. PMID 11086294 DOI: 10.1002/1096-9861(20000101)429:1<127::Aid-Cne10>3.0.Co;2-H |
0.41 |
|
| 2000 |
Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M, Mizuta M, Eisenbarth GS, Hutton JC. Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes. Diabetologia. 43: 1293-301. PMID 11079748 DOI: 10.1007/S001250051525 |
0.468 |
|
| 2000 |
Goodge KA, Hutton JC. Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreaticβ-cell Seminars in Cell & Developmental Biology. 11: 235-242. PMID 10966857 DOI: 10.1006/Scdb.2000.0172 |
0.412 |
|
| 2000 |
Tree TIM, O'Byrne D, Tremble JM, MacFarlane WM, Haskins K, James RFL, Docherty K, Hutton JC, Banga JP. Evidence for recognition of novel islet T cell antigens by granule- specific T cell lines from new onset type 1 diabetic patients Clinical and Experimental Immunology. 121: 100-105. PMID 10886245 DOI: 10.1046/J.1365-2249.2000.01279.X |
0.41 |
|
| 1999 |
Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, ... ... Hutton JC, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 42: A1-A330. PMID 27770183 DOI: 10.1007/Bf03375458 |
0.338 |
|
| 1999 |
Kelemen K, Crawford ML, Gill RG, Hutton JC, Wegmann D. Cellular immune response to phogrin in the NOD mouse: Cloned T-cells cause destruction of islet transplants Diabetes. 48: 1529-1534. PMID 10426369 DOI: 10.2337/Diabetes.48.8.1529 |
0.391 |
|
| 1999 |
Hurlbert MS, Zhou W, Wasmeier C, Kaddis FG, Hutton JC, Freed CR. Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes Diabetes. 48: 649-651. PMID 10078572 DOI: 10.2337/Diabetes.48.3.649 |
0.418 |
|
| 1999 |
Ebert DH, Bischof LJ, Streeper RS, Chapman SC, Svitek CA, Goldman JK, Mathews CE, Leiter EH, Hutton JC, O'Brien RM. Structure and promoter activity of an islet-specific glucose-6- phosphatase catalytic subunit-related gene Diabetes. 48: 543-551. PMID 10078554 DOI: 10.2337/Diabetes.48.3.543 |
0.343 |
|
| 1999 |
Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC. Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 48: 531-42. PMID 10078553 DOI: 10.2337/Diabetes.48.3.531 |
0.413 |
|
| 1999 |
Wasmeier C, Hutton JC. Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue. Biochemical Journal. 341: 563-569. DOI: 10.1042/Bj3410563 |
0.369 |
|
| 1999 |
Wasmeier C, Creemers JWM, Jackson RS, Hutton JC. Proinsulin Processing and Insulin Storage Advances in Molecular and Cell Biology. 29: 125-150. DOI: 10.1016/S1569-2558(08)60091-0 |
0.385 |
|
| 1998 |
Pouli AE, Emmanouilidou E, Zhao C, Wasmeier C, Hutton JC, Rutter GA. Secretory-granule dynamics visualized in vivo with a phogrin–green fluorescent protein chimaera Biochemical Journal. 333: 193-199. PMID 9639579 DOI: 10.1042/Bj3330193 |
0.357 |
|
| 1998 |
Kawasaki E, Yu L, Rewers MJ, Hutton JC, Eisenbarth GS. Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. Diabetes. 47: 733-742. PMID 9588444 DOI: 10.2337/Diabetes.47.5.733 |
0.425 |
|
| 1997 |
Kallan AA, Duinkerken G, de Jong R, van den Elsen P, Hutton JC, Martin S, Roep BO, de Vries RR. Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens. Journal of Autoimmunity. 10: 589-98. PMID 9451599 DOI: 10.1006/Jaut.1997.0167 |
0.348 |
|
| 1997 |
Hutton JC. Tetrahymena: the key to the genetic analysis of the regulated pathway of polypeptide secretion? Proceedings of the National Academy of Sciences of the United States of America. 94: 10490-10492. PMID 9380665 DOI: 10.1073/Pnas.94.20.10490 |
0.364 |
|
| 1997 |
Kaiser N, Bailyes EM, Schneider BS, Cerasi E, Steiner DF, Hutton JC, Gross DJ. Characterization of the unusual insulin of Psammomys obesus, a rodent with nutrition-induced NIDDM-like syndrome. Diabetes. 46: 953-7. PMID 9166665 DOI: 10.2337/Diab.46.6.953 |
0.404 |
|
| 1997 |
Tree TIM, Tremble JM, Bailyes E, Banga JP, Hutton J. T-cell lines from type 1 diabetic patients to insulinoma proteins: Unresponsiveness to candidate β cell autoantigens suggests recognition of novel targets Immunology Letters. 56: 459. DOI: 10.1016/S0165-2478(97)88880-3 |
0.392 |
|
| 1996 |
Kawasaki E, Hutton JC, Eisenbarth GS. Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. Biochemical and Biophysical Research Communications. 227: 440-447. PMID 8878534 DOI: 10.1006/Bbrc.1996.1526 |
0.406 |
|
| 1996 |
Neophytou PI, Ozegbe P, Healey D, Quartey-Papafio R, Cooke A, Hutton JC. Development of a procedure for the direct cloning of T-cell epitopes using bacterial expression systems. Journal of Immunological Methods. 196: 63-72. PMID 8841444 DOI: 10.1016/0022-1759(96)00118-4 |
0.359 |
|
| 1996 |
Kawasaki E, Eisenbarth GS, Wasmeier C, Hutton JC. Autoantibodies to Protein Tyrosine Phosphatase-Like Proteins In Type I Diabetes: Overlapping Specificities To Phogrin And ICA512/IA-2 Diabetes. 45: 1344-1349. PMID 8826969 DOI: 10.2337/Diab.45.10.1344 |
0.435 |
|
| 1996 |
Hawkes CJ, Wasmeier C, Christie MR, Hutton JC. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes. 45: 1187-92. PMID 8772720 DOI: 10.2337/Diab.45.9.1187 |
0.339 |
|
| 1996 |
Neophytou PI, Roep BO, Arden SD, Muir EM, Duinkerken G, Kallan A, de Vries RR, Hutton JC. T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient. Proceedings of the National Academy of Sciences of the United States of America. 93: 2014-8. PMID 8700877 DOI: 10.1073/Pnas.93.5.2014 |
0.456 |
|
| 1996 |
Wasmeier C, Hutton JC. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. Journal of Biological Chemistry. 271: 18161-18170. PMID 8663434 DOI: 10.1074/Jbc.271.30.18161 |
0.444 |
|
| 1996 |
Arden SD, Roep BO, Neophytou PI, Usac EF, Duinkerken G, de Vries RR, Hutton JC. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. The Journal of Clinical Investigation. 97: 551-61. PMID 8567980 DOI: 10.1172/Jci118448 |
0.446 |
|
| 1995 |
Kallan AA, Roep BO, Arden SD, Hutton JC, de Vries RR. Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens. Journal of Autoimmunity. 8: 887-99. PMID 8824713 DOI: 10.1016/S0896-8411(95)80024-7 |
0.405 |
|
| 1995 |
Guest PC, Arden SD, Rutherford NG, Hutton JC. The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans. Molecular and Cellular Endocrinology. 113: 99-108. PMID 8674818 DOI: 10.1016/0303-7207(95)03619-I |
0.364 |
|
| 1995 |
Roep BO, Kallan AA, Duinkerken G, Arden SD, Hutton JC, Bruining GJ, de Vries RR. T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes. 44: 278-83. PMID 7883114 DOI: 10.2337/Diab.44.3.278 |
0.404 |
|
| 1995 |
Healey D, Ozegbe P, Arden S, Chandler P, Hutton J, Cooke A. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. The Journal of Clinical Investigation. 95: 2979-85. PMID 7769140 DOI: 10.1172/Jci118006 |
0.446 |
|
| 1995 |
Bailyes EM, Shennan KI, Usac EF, Arden SD, Guest PC, Docherty K, Hutton JC. Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2. The Biochemical Journal. 309: 587-94. PMID 7626024 DOI: 10.1042/Bj3090587 |
0.337 |
|
| 1994 |
Arden SD, Rutherford NG, Guest PC, Curry WJ, Bailyes EM, Johnston CF, Hutton JC. The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. The Biochemical Journal. 298: 521-8. PMID 8141763 DOI: 10.1042/Bj2980521 |
0.343 |
|
| 1994 |
Roep BO, Kallan AA, Hazenbos WLW, Bruining JG, Bailyes EM, Arden SD, Hutton JC, Vries RRPD, Bonifacio E, Boitard C. T-cell reactivity to 38 kD insulin-secretory granule protein in patients with recent onset type 1 diabetes. Journal of Endocrinological Investigation. 17: 559-563. PMID 7829830 DOI: 10.1007/Bf03347750 |
0.467 |
|
| 1992 |
Bailyes EM, Shennan IJ, Seal AJ, Smeekens SP, Steiner DF, Hutton JC, Docherty K. A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase Biochemical Journal. 285: 391-394. PMID 1637332 DOI: 10.1042/Bj2850391 |
0.341 |
|
| 1992 |
Bailyes EM, Hutton JC. Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay. Biochemical Journal. 286: 223-229. PMID 1520272 DOI: 10.1042/Bj2860223 |
0.332 |
|
| 1991 |
Guest PC, Bailyes EM, Rutherford NG, Hutton JC. Insulin Secretory Granule Biogenesis : Co-Ordinate Regulation Of The Biosynthesis Of The Majority Of Constituent Proteins Biochemical Journal. 274: 73-78. PMID 2001253 DOI: 10.1042/Bj2740073 |
0.381 |
|
| 1991 |
Scott V, Clark AR, Hutton JC, Docherty K. Two proteins act as the IUF1 insulin gene enhancer binding factor Febs Letters. 290: 27-30. PMID 1915886 DOI: 10.1016/0014-5793(91)81217-V |
0.363 |
|
| 1991 |
Guest PC, Ravazzola M, Davidson HW, Orci L, Hutton JC. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology. 129: 734-740. PMID 1855471 DOI: 10.1210/Endo-129-2-734 |
0.379 |
|
| 1991 |
Curry WJ, Johnston CF, Hutton JC, Arden SD, Rutherford NG, Shaw C, Buchanan KD. The tissue distribution of rat chromogranin A-derived peptides: evidence for differential tissue processing from sequence specific antisera. Histochemistry. 96: 531-8. PMID 1769862 DOI: 10.1007/Bf00267079 |
0.313 |
|
| 1991 |
Roep BO, Kallan AA, Hazenbos WL, Bruining GJ, Bailyes EM, Arden SD, Hutton JC, de Vries RR. T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet. 337: 1439-41. PMID 1675318 DOI: 10.1016/0140-6736(91)93127-U |
0.466 |
|
| 1990 |
Roep BO, Arden SD, de Vries RR, Hutton JC. T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature. 345: 632-4. PMID 2190098 DOI: 10.1038/345632A0 |
0.472 |
|
| 1990 |
Hutton JC, Bailyes EM, Rhodes CJ, Rutherford NG, Arden SD, Guest PC. Biosynthesis and storage of insulin. Biochemical Society Transactions. 18: 122-4. PMID 2185075 DOI: 10.1042/Bst0180122 |
0.354 |
|
| 1989 |
Guest PC, Lowing C, Arden SD, Gray IP, Hutton JC. A rapid, sensitive and versatile two-site immunoradiometric assay for insulin. Molecular and Cellular Endocrinology. 67: 173-8. PMID 2693160 DOI: 10.1016/0303-7207(89)90207-4 |
0.386 |
|
| 1989 |
Guest PC, Rhodes CJ, Hutton JC. Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochemical Journal. 257: 431-437. PMID 2649074 DOI: 10.1042/Bj2570431 |
0.394 |
|
| 1989 |
Guest PC, Pipeleers D, Rossier J, Rhodes CJ, Hutton JC. Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. The Biochemical Journal. 264: 503-8. PMID 2481446 DOI: 10.1042/Bj2640503 |
0.379 |
|
| 1988 |
Davidson HW, Rhodes CJ, Hutton JC. Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases Nature. 333: 93-96. PMID 3283564 DOI: 10.1038/333093A0 |
0.384 |
|
| 1988 |
Hutton JC, Peshavaria M, Johnston CF, Ravazzola M, Orci L. Immunolocalization of betagranin: a chromogranin A-related protein of the pancreatic B-cell. Endocrinology. 122: 1014-1020. PMID 3277836 DOI: 10.1210/Endo-122-3-1014 |
0.368 |
|
| 1988 |
Hutton JC, Nielsen E, Kastern W. The molecular cloning of the chromogranin A-like precursor of β-granin and pancreastatin from the endocrine pancreas Febs Letters. 236: 269-274. PMID 3044825 DOI: 10.1016/0014-5793(88)80036-X |
0.314 |
|
| 1987 |
Davidson HW, Peshavaria M, Hutton JC. Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules Biochemical Journal. 246: 279-286. PMID 3318807 DOI: 10.1042/Bj2460279 |
0.374 |
|
| 1987 |
Hutton JC, Davidson HW, Grimaldi KA, Peshavaria M. Biosynthesis of betagranin in pancreatic β-cells: identification of a chromogranin A-like precursor and its parallel processing with proinsulin Biochemical Journal. 244: 449-456. PMID 3311030 DOI: 10.1042/Bj2440449 |
0.422 |
|
| 1987 |
Davidson HW, Hutton JC. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochemical Journal. 245: 575-582. PMID 2822027 DOI: 10.1042/Bj2450575 |
0.404 |
|
| 1987 |
Grimaldi KA, Siddle K, Hutton JC. Biosynthesis of insulin secretory granule membrane proteins. Control by glucose. Biochemical Journal. 245: 567-573. PMID 2822026 DOI: 10.1042/Bj2450567 |
0.419 |
|
| 1987 |
Hutton JC, Davidson HW, Peshavaria M. Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10). Biochemical Journal. 244: 457-464. PMID 2822006 DOI: 10.1042/Bj2440457 |
0.314 |
|
| 1987 |
Grimaldi KA, Hutton JC, Siddle K. Production and characterization of monoclonal antibodies to insulin secretory granule membranes. Biochemical Journal. 245: 557-566. PMID 2444218 DOI: 10.1042/Bj2450557 |
0.358 |
|
| 1986 |
Hutton JC, Peshavaria M, Davidson HW, Grimaldi K, Strandmann RPV, Siddle K. The insulin secretory granule: features and functions in common with other endocrine granules. Advances in Experimental Medicine and Biology. 211: 385-396. PMID 3300195 DOI: 10.1007/978-1-4684-5314-0_36 |
0.395 |
|
| 1985 |
Hutton JC, Hansen F, Peshavaria M. β-Granins: 21 kDa co-secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A Febs Letters. 188: 336-340. PMID 3896848 DOI: 10.1016/0014-5793(85)80398-7 |
0.379 |
|
| 1985 |
Hutton JC, Hansen F, Peshavaria M. Betagranins; 21,000 mw peptides cosecreted with insulin are homologous to adrenal medulla chromogranin A Regulatory Peptides. 13: 75. DOI: 10.1016/0167-0115(85)90107-7 |
0.344 |
|
| 1984 |
Sopwith AM, Hales CN, Hutton JC. Pancreatic B-cells secrete a range of novel peptides besides insulin. Biochimica Et Biophysica Acta. 803: 342-345. PMID 6322863 DOI: 10.1016/0167-4889(84)90127-7 |
0.356 |
|
| 1984 |
Hutton JC, Peshavaria M, Brocklehurst KW. Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma. Biochemical Journal. 224: 483-490. PMID 6097221 DOI: 10.1042/Bj2240483 |
0.347 |
|
| 1983 |
Hutton JC, Penn EJ, Peshavaria M. Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochemical Journal. 210: 297-305. PMID 6344863 DOI: 10.1042/Bj2100297 |
0.328 |
|
| 1983 |
Docherty K, Hutton JC. Carboxypeptidase activity in the insulin secretory granule Febs Letters. 162: 137-141. PMID 6311629 DOI: 10.1016/0014-5793(83)81065-5 |
0.354 |
|
| 1983 |
Docherty K, Hutton J, Steiner D. Enzymes involved in the conversion of proinsulin to insulin Regulatory Peptides. 7: 283. DOI: 10.1016/0167-0115(83)90047-2 |
0.346 |
|
| 1982 |
Hutton JC, Penn EJ, Peshavaria M. Isolation and Characterisation of Insulin Secretory Granules from a Rat Islet Cell Tumour Diabetologia. 23: 365-373. PMID 6292032 DOI: 10.1007/Bf00253746 |
0.421 |
|
| 1982 |
Hutton JC. The internal pH and membrane potential of the insulin-secretory granule Biochemical Journal. 204: 171-178. PMID 6126183 DOI: 10.1042/Bj2040171 |
0.321 |
|
| 1982 |
Hutton JC, Peshavaria M. Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules Biochemical Journal. 204: 161-170. PMID 6126182 DOI: 10.1042/Bj2040161 |
0.367 |
|
| 1981 |
Hutton JC, Penn EJ, Jackson P, Hales CN. Isolation and characterization of calmodulin from an insulin-secreting tumour. Biochemical Journal. 193: 875-885. PMID 6272721 DOI: 10.1042/Bj1930875 |
0.364 |
|
| 1981 |
Sopwith AM, Hutton JC, Naber SP, Chick WL, Hales CN. Insulin secretion by a transplantable rat islet cell tumour. Diabetologia. 21: 224-229. PMID 6117493 DOI: 10.1007/Bf00252658 |
0.4 |
|
| 1981 |
Penn EJ, Hutton JC, Hales CN. Calmodulin And Calmodulin-Binding Proteins In An Insulin Secreting Tumour Biochemical Society Transactions. 9. DOI: 10.1042/Bst009177Pb |
0.363 |
|
| 1980 |
Malaisse WJ, Hutton JC, Carpinelli AR, Herchuelz A, Sener A. The Stimulus-secretion Coupling of Amino Acid-induced Insulin Release: Metabolism and Cationic Effects of Leucine Diabetes. 29: 431-437. PMID 6769728 DOI: 10.2337/Diab.29.6.431 |
0.307 |
|
| 1979 |
Malaisse WJ, Kawazu S, Herchuelz A, Hutton JC, Somers G, Devis G, Sener A. The stimulus secretion coupling of glucose-induced insulin release. Archives of Biochemistry and Biophysics. 194: 49-62. PMID 375835 DOI: 10.1016/0003-9861(79)90594-0 |
0.361 |
|
| 1978 |
Malaisse WJ, Hutton J, Kawazu S, Sener A. The Stimulus‐Secretion Coupling of Glucose‐Induced Insulin Release Febs Journal. 87: 121-130. PMID 27353 DOI: 10.1111/J.1432-1033.1978.Tb12357.X |
0.366 |
|
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