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Liewei Wang - Publications

Affiliations: 
Molecular Pharmacology and Experimental Therapeutics College of Medicine - Mayo Clinic 
Area:
Pharmacology, Genetics, Molecular Biology
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Year Citation  Score
2022 Nguyen TTL, Gao H, Liu D, Philips TJ, Ye Z, Lee JH, Shi GX, Copenhaver K, Zhang L, Wei L, Yu J, Zhang H, Barath A, Luong M, Zhang C, ... ... Wang L, et al. Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. Nucleic Acids Research. PMID 36399508 DOI: 10.1093/nar/gkac1045  0.308
2022 Thompson KJ, Leon-Ferre RA, Sinnwell JP, Zahrieh DM, Suman VJ, Metzger FO, Asad S, Stover DG, Carey L, Sikov WM, Ingle JN, Liu MC, Carter JM, Klee EW, Weinshilboum RM, ... ... Wang L, et al. Luminal androgen receptor breast cancer subtype and investigation of the microenvironment and neoadjuvant chemotherapy response. Nar Cancer. 4: zcac018. PMID 35734391 DOI: 10.1093/narcan/zcac018  0.312
2022 Fasching PA, Liu D, Scully S, Ingle JN, Lyra PC, Rack B, Hein A, Ekici AB, Reis A, Schneeweiss A, Tesch H, Fehm TN, Heinrich G, Beckmann MW, Ruebner M, ... ... Wang L, et al. Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Breast Cancer Patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35653140 DOI: 10.1158/1078-0432.CCR-20-4774  0.307
2021 Zhuang Y, Grainger JM, Vedell PT, Yu J, Moyer AM, Gao H, Fan XY, Qin S, Liu D, Kalari KR, Goetz MP, Boughey JC, Weinshilboum RM, Wang L. Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX). Npj Breast Cancer. 7: 79. PMID 34145270 DOI: 10.1038/s41523-021-00285-x  0.301
2021 Cairns J, Kalari KR, Ingle JN, Shepherd LE, Ellis MJ, Goss PE, Barman P, Carlson EE, Goodnature B, Goetz MP, Weinshilboum RM, Gao H, Wang L. Interaction between SNP Genotype and Efficacy of Anastrozole and Exemestane in Early Stage Breast Cancer. Clinical Pharmacology and Therapeutics. PMID 34048027 DOI: 10.1002/cpt.2311  0.327
2020 Wen S, He Y, Wang L, Zhang J, Quan C, Niu Y, Huang H. Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer. Oncogene. PMID 32917955 DOI: 10.1038/S41388-020-01456-Z  0.349
2020 Cairns J, Ingle JN, Dudenkov TTM, Kalari KR, Carlson EE, Na J, Buzdar AU, Robson ME, Ellis MJ, Goss PE, Shepherd LE, Goodnature B, Goetz MP, Weinshilboum RM, Li H, ... ... Wang L, et al. Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action. Jci Insight. PMID 32701512 DOI: 10.1172/Jci.Insight.137571  0.447
2020 Ingle JN, Kalari KR, Barman P, Shepherd LE, Ellis MJ, Goss PE, Buzdar AU, Robson ME, Cairns J, Carlson EE, Eyman Casey A, Hoskin TL, Goodnature BA, Haddad TC, Goetz MP, ... ... Wang L, et al. Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer. Pharmacogenetics and Genomics. PMID 32649577 DOI: 10.1097/Fpc.0000000000000415  0.366
2020 Zayas J, Qin S, Yu J, Ingle JN, Wang L. Functional genomics based on germline genome-wide association studies of endocrine therapy for breast cancer. Pharmacogenomics. PMID 32539536 DOI: 10.2217/Pgs-2019-0191  0.448
2020 John A, Qin B, Kalari KR, Wang L, Yu J. Patient-specific multi-omics models and the application in personalized combination therapy. Future Oncology (London, England). PMID 32462937 DOI: 10.2217/Fon-2020-0119  0.314
2020 Du M, Tian Y, Tan W, Wang L, Wang L, Kilari D, Huang CC, Wang L, Kohli M. Plasma cell-free DNA-based predictors of response to abiraterone acetate/prednisone and prognostic factors in metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases. PMID 32203070 DOI: 10.1038/S41391-020-0224-4  0.351
2020 Ingle JN, Cairns J, Suman VJ, Shepherd LE, Fasching PA, Hoskin TL, Singh RJ, Desta Z, Kalari KR, Ellis MJ, Goss PE, Chen BE, Volz B, Barman P, Carlson EE, ... ... Wang L, et al. Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor α. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32098767 DOI: 10.1158/1078-0432.Ccr-19-3091  0.35
2020 Zhang L, Sarangi V, Moon I, Yu J, Liu D, Devarajan S, Reid JM, Kalari KR, Wang L, Weinshilboum R. CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants. Clinical and Translational Science. PMID 32004414 DOI: 10.1111/Cts.12758  0.351
2020 Leon-Ferre RA, McGrath K, Carter JM, Kalari KR, Suman VJ, Weinshilboum R, Wang L, Knutson KL, Ansell SM, Boughey JC, Villasboas JC, Goetz MP. Abstract P5-04-09: Deep phenotyping using CyTOF identifies peripheral blood immune signatures associated with clinical outcomes and molecular subtypes in patients with early-stage triple negative breast cancer (TNBC) Cancer Research. DOI: 10.1158/1538-7445.Sabcs19-P5-04-09  0.349
2020 Grainger JM, Yu J, Kalari KR, Vedell P, Thompson K, Goetz MP, Suman VJ, Boughey JC, Wang L. Abstract 1928: Study of copy number amplification and chemo-response in triple negative breast cancer Cancer Research. 80: 1928-1928. DOI: 10.1158/1538-7445.Am2020-1928  0.44
2020 Myasoedova E, Athreya A, Crowson CS, Weinshilboum R, Wang L, Matteson E. Fri0046 Pharmacogenomics-Driven Individualized Prediction Of Treatment Response To Methotrexate In Patients With Rheumatoid Arthritis: A Machine Learning Approach Annals of the Rheumatic Diseases. 79: 598-598. DOI: 10.1136/Annrheumdis-2020-Eular.4993  0.322
2019 Yu J, Zayas J, Qin B, Wang L. Targeting DNA methylation for treating triple-negative breast cancer. Pharmacogenomics. 20: 1151-1157. PMID 31755366 DOI: 10.2217/Pgs-2019-0078  0.374
2019 Qin S, Eugene AR, Liu D, Zhang L, Neavin D, Biernacka JM, Yu J, Weinshilboum RM, Wang L. Dual roles for the TSPYL family in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors in MDD patients. Clinical Pharmacology and Therapeutics. PMID 31628858 DOI: 10.1002/Cpt.1692  0.35
2019 Shee K, Wells JD, Ung M, Hampsch RA, Traphagen NA, Yang W, Liu SC, Zeldenrust MA, Wang L, Kalari KR, Yu J, Boughey JC, Demidenko E, Kettenbach AN, Cheng C, et al. A transcriptionally-definable subgroup of triple-negative breast and ovarian cancer samples shows sensitivity to HSP90 inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31558472 DOI: 10.1158/1078-0432.Ccr-18-2213  0.381
2019 Ruddy KJ, Schaid DJ, Partridge AH, Larson NB, Batzler A, Häberle L, Dittrich R, Widschwendter P, Fink V, Bauer E, Schwitulla J, Rübner M, Ekici AB, Aivazova-Fuchs V, Stewart EA, ... ... Wang L, et al. Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer. Fertility and Sterility. PMID 31371054 DOI: 10.1016/J.Fertnstert.2019.05.018  0.353
2019 Neavin DR, Lee JH, Liu D, Ye Z, Li H, Wang L, Ordog T, Weinshilboum RM. Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor Binding Sites Influence AHR Ligand-Dependent Gene Expression. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31292129 DOI: 10.1124/Dmd.119.087312  0.407
2019 Ingle JN, Kalari KR, Momozawa Y, Kubo M, Furukawa Y, Shepherd LE, Ellis MJ, Goss PE, Barman P, Carlson EE, Sinnwell JP, Tang X, Goetz MP, Chen BE, Cairns J, ... ... Wang L, et al. Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer. Pharmacogenetics and Genomics. PMID 31211741 DOI: 10.1097/Fpc.0000000000000382  0.393
2019 Pereira NL, Rihal CS, So DYF, Rosenberg Y, Lennon RJ, Mathew V, Goodman SG, Weinshilboum RM, Wang L, Baudhuin LM, Lerman A, Hasan A, Iturriaga E, Fu YP, Geller N, et al. Clopidogrel Pharmacogenetics. Circulation. Cardiovascular Interventions. 12: e007811. PMID 30998396 DOI: 10.1161/Circinterventions.119.007811  0.316
2019 Cairns J, Ingle JN, Kalari KR, Shepherd LE, Kubo M, Goetz MP, Weinshilboum RM, Wang L. The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. Breast Cancer Research : Bcr. 21: 47. PMID 30944027 DOI: 10.1186/S13058-019-1130-3  0.401
2019 Wang G, Qin S, Zayas J, Ingle JN, Liu M, Weinshilboum RM, Shen K, Wang L. 4-Hydroxytamoxifen enhances sensitivity of estrogen receptor α-positive breast cancer to docetaxel in an estrogen and ZNF423 SNP-dependent fashion. Breast Cancer Research and Treatment. PMID 30937657 DOI: 10.1007/S10549-019-05194-Z  0.442
2019 Liu D, Qin S, Ray B, Kalari KR, Wang L, Weinshilboum RM. Correction: Single nucleotide polymorphisms (snps) distant from xenobiotic response elements can modulate aryl hydrocarbon receptor function: snp-dependent cyp1a1 induction (Drug Metabolism and Disposition (2018) 46:9 (1372-1381) DOI: 10.1124/dmd.118.082164) Drug Metabolism and Disposition. PMID 30760463 DOI: 10.1124/Dmd.117.082164Err  0.346
2019 Devarajan S, Moon I, Ho M, Larson NB, Neavin DR, Moyer AM, Black JL, Bielinski SJ, Scherer SE, Wang L, Weinshilboum RM, Reid JM. Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30745309 DOI: 10.1124/Dmd.118.084269  0.337
2019 Zhuang Y, Ly RC, Frazier CV, Yu J, Qin S, Fan XY, Goetz MP, Boughey JC, Weinshilboum R, Wang L. The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer. Cancer & Metabolism. 7: 1. PMID 30697423 DOI: 10.1186/S40170-018-0193-4  0.394
2019 Dudenkov TM, Liu D, Cairns J, Devarajan S, Zhuang Y, Ingle JN, Buzdar AU, Robson ME, Kubo M, Batzler A, Barman P, Jenkins GD, Carlson EE, Goetz MP, Northfelt DW, ... ... Wang L, et al. Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction between SLC38A7 and ALPPL2. Clinical Pharmacology and Therapeutics. PMID 30648747 DOI: 10.1002/Cpt.1359  0.429
2019 Giridhar K, Sosa C, Sicotte H, Wang L, Wang L, Sinnwell JP, Tan W, Costello BA, Quevedo F, Pitot HC, Bryce AH, Jimenez RE, Weinshilboum RM, Dehm S, Kalari KR, et al. Evolution of androgen receptor variant (ARV) profiles in serial metastatic solid and liquid biopsies in metastatic castrate resistant prostate cancer (mCRPC) treated with abiraterone acetate/ prednisone (AA/P). Journal of Clinical Oncology. 37: e16559-e16559. DOI: 10.1200/Jco.2019.37.15_Suppl.E16559  0.304
2019 Wang G, Qin S, Zayas J, Ingle JN, Liu M, Weinshilboum R, Shen K, Wang L. Abstract 2940: 4-Hydroxytamoxifen enhances sensitivity of estrogen receptor α-positive breast cancer to docetaxel in an estrogen andZNF423SNP-dependent fashion Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2940  0.32
2019 Yu J, Qin B, Boughey J, Goetz M, Wang L. Abstract 2980: The role of USP7 and USP7 inhibitor in HER2+ breast cancer treatment Cancer Research. 79: 2980-2980. DOI: 10.1158/1538-7445.Am2019-2980  0.415
2018 Wu X, Li Y, Liu X, Chen C, Harrington SM, Cao S, Xie T, Orzechowski A, Pham T, Mansfield AS, Yan Y, Kwon ED, Wang L, Ling K, Dong H. Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy. Heliyon. 4: e01039. PMID 30603685 DOI: 10.1016/J.Heliyon.2018.E01039  0.337
2018 Tu X, Kahila MM, Zhou Q, Yu J, Kalari KR, Wang L, Harmsen WS, Yuan J, Boughey JC, Goetz MP, Sarkaria JN, Lou Z, Mutter RW. ATR inhibition is a promising radiosensitizing strategy for triple negative breast cancer. Molecular Cancer Therapeutics. PMID 30166399 DOI: 10.1158/1535-7163.MCT-18-0470  0.32
2018 Baheti S, Tang X, O'Brien DR, Chia N, Roberts LR, Nelson H, Boughey JC, Wang L, Goetz MP, Kocher JA, Kalari KR. HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data. Bmc Bioinformatics. 19: 271. PMID 30016933 DOI: 10.1186/S12859-018-2260-9  0.319
2018 Athreya AP, Gaglio AJ, Cairns J, Kalari KR, Weinshilboum RM, Wang L, Kalbarczyk ZT, Iyer RK. Machine Learning helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer. Ieee Transactions On Nanobioscience. PMID 29994716 DOI: 10.1109/Tnb.2018.2851997  0.402
2018 Kohli M, Li J, Du M, Hillman DW, Dehm SM, Tan W, Carlson R, Campion MB, Wang L, Wang L, Zhang H, Zhang P, Kilari D, Huang CC, Wang L. Prognostic association of plasma cell-free DNA-based androgen receptor amplification and circulating tumor cells in pre-chemotherapy metastatic castration-resistant prostate cancer patients. Prostate Cancer and Prostatic Diseases. PMID 29858592 DOI: 10.1038/S41391-018-0043-Z  0.341
2018 Ingle JN, Kalari KR, Wickerham DL, von Minckwitz G, Fasching PA, Furukawa Y, Mushiroda T, Goetz MP, Barman P, Carlson EE, Rastogi P, Costantino JP, Cairns J, Paik S, Bear HD, ... ... Wang L, et al. Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab. Pharmacogenetics and Genomics. 28: 147-152. PMID 29768301 DOI: 10.1097/FPC.0000000000000337  0.311
2018 Yu J, Qin B, Moyer AM, Nowsheen S, Liu T, Qin S, Zhuang Y, Liu D, Lu SW, Kalari KR, Visscher DW, Copland JA, McLaughlin SA, Moreno-Aspitia A, Northfelt DW, ... ... Wang L, et al. DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine. The Journal of Clinical Investigation. PMID 29708513 DOI: 10.1172/Jci97924  0.402
2018 Bidadi B, Liu D, Kalari KR, Rubner M, Hein A, Beckmann MW, Rack B, Janni W, Fasching PA, Weinshilboum RM, Wang L. Pathway-Based Analysis of Genome-Wide Association Data Identified SNPs inas Biomarker for Chemotherapy- Induced Neutropenia in Breast Cancer Patients. Frontiers in Pharmacology. 9: 158. PMID 29593529 DOI: 10.3389/Fphar.2018.00158  0.496
2018 He Y, Lu J, Ye Z, Hao S, Wang L, Kohli M, Tindall DJ, Li B, Zhu R, Wang L, Huang H. Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer. Nucleic Acids Research. PMID 29309643 DOI: 10.1093/Nar/Gkx1306  0.381
2018 Cairns J, Ingle J, Shepherd L, Kubo M, Goetz M, Weinshilboum R, Kalari K, Wang L. Abstract P5-07-01: LncRNA MIR2052HG regulates ERα level and endocrine resistance through LMTK3 by recruiting early growth response protein 1 Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P5-07-01  0.327
2018 Mutter RW, Kahila MM, Tu X, Zhou Q, Yu J, Kalari KR, Wang L, Boughey JC, Goetz MP, Sarkaria JN, Lou Z. Abstract 840: ATR inhibition is a promising radiosensitizing strategy for chemotherapy-resistant triple negative breast cancer (TNBC) Cancer Research. 78: 840-840. DOI: 10.1158/1538-7445.Am2018-840  0.426
2017 Yu J, Qin B, Moyer AM, Sinnwell JP, Thompson KJ, Copland JA, Marlow LA, Miller JL, Yin P, Gao B, Minter-Dykhouse K, Tang X, McLaughlin SA, Moreno-Aspitia A, Schweitzer A, ... ... Wang L, et al. Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study. Breast Cancer Research : Bcr. 19: 130. PMID 29212525 DOI: 10.1186/S13058-017-0920-8  0.396
2017 Fasching PA, Häberle L, Rack B, Li L, Hein A, Ekici AB, Reis A, Lux MP, Cunningham JM, Ruebner M, Jenkins G, Fridley B, Schneeweiss A, Tesch H, Lichtenegger W, ... ... Wang L, et al. Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity. Oncotarget. 8: 78133-78143. PMID 29100455 DOI: 10.18632/Oncotarget.17726  0.43
2017 Qin S, Liu D, Kohli M, Wang L, Vedell PT, Hillman DW, Niu N, Yu J, Weinshilboum RM, Wang L. TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer. Clinical Pharmacology and Therapeutics. PMID 29027195 DOI: 10.1002/Cpt.907  0.416
2017 Cairns J, Ingle JN, Wickerham LD, Weinshilboum R, Liu M, Wang L. SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1. Plos Genetics. 13: e1007031. PMID 28968398 DOI: 10.1371/journal.pgen.1007031  0.377
2017 Liu D, Ho MF, Schaid DJ, Scherer SE, Kalari K, Liu M, Biernacka J, Yee V, Evans J, Carlson E, Goetz MP, Kubo M, Wickerham DL, Wang L, Ingle JN, et al. Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes. Npj Breast Cancer. 3: 30. PMID 28856246 DOI: 10.1038/s41523-017-0036-4  0.345
2017 Qin S, Ingle JN, Liu M, Yu J, Wickerham DL, Kubo M, Weinshilboum RM, Wang L. Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion. Breast Cancer Research : Bcr. 19: 95. PMID 28821270 DOI: 10.1186/s13058-017-0890-x  0.322
2017 Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, ... ... Wang L, et al. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature Medicine. PMID 28805820 DOI: 10.1038/Nm.4378  0.357
2017 Ho MF, Ingle JN, Bongartz T, Kalari KR, Goss PE, Shepherd LE, Mushiroda T, Kubo M, Wang L, Weinshilboum RM. TCL1A SNPs and estrogen-mediated toll-like receptor-MYD88-dependent NF-κB activation: SNP and SERM-dependent modification of inflammation and immune response. Molecular Pharmacology. PMID 28615284 DOI: 10.1124/Mol.117.108340  0.404
2017 Fasching PA, Häberle L, Rack B, Li L, Hein A, Ekici AB, Reis A, Lux MP, Cunningham JM, Ruebner M, Jenkins G, Fridley B, Schneeweiss A, Tesch H, Lichtenegger W, ... ... Wang L, et al. Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity. Oncotarget. PMID 28537877 DOI: 10.18632/oncotarget.17726  0.321
2017 Kohli M, Ho Y, Hillman DW, Van Etten JL, Henzler C, Yang R, Sperger JM, Li Y, Tseng E, Hon T, Clark T, Tan W, Carlson RE, Wang L, Sicotte H, ... ... Wang L, et al. Androgen receptor variant AR-V9 is co-expressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28473535 DOI: 10.1158/1078-0432.Ccr-17-0017  0.323
2017 Dudenkov TM, Ingle JN, Buzdar AU, Robson ME, Kubo M, Ibrahim-Zada I, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Barman P, Goetz MP, Northfelt DW, Moreno-Aspita A, Williard CV, ... ... Wang L, et al. SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway. Breast Cancer Research and Treatment. PMID 28429243 DOI: 10.1007/S10549-017-4243-3  0.378
2017 Athreya AP, Kalari KR, Cairns J, Gaglio AJ, Wills QF, Niu N, Weinshilboum R, Iyer RK, Wang L. Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer. Oncotarget. 27199-27215. PMID 28423712 DOI: 10.18632/Oncotarget.16109  0.407
2017 Goetz MP, Kalari KR, Suman VJ, Moyer AM, Yu J, Visscher DW, Dockter TJ, Vedell PT, Sinnwell JP, Tang X, Thompson KJ, McLaughlin SA, Moreno-Aspitia A, Copland JA, Northfelt DW, ... ... Wang L, et al. Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer. Journal of the National Cancer Institute. 109. PMID 28376176 DOI: 10.1093/Jnci/Djw306  0.387
2017 Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, Qin B, Li Y, Wu C, Ren T, Han Y, Yin P, Kim J, Lee S, Lin J, ... ... Wang L, et al. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nature Communications. 8: 13923. PMID 28067227 DOI: 10.1038/Ncomms13923  0.367
2017 Kohli M, Wang L, Dehm S, Hillman DW, Sicotte H, Gormley M, Bhargava V, Ricci DS, Li W, Tan W, Costello BA, Pitot HC, Dronca RS, Ho TH, Bryce AH, ... ... Wang L, et al. Association of Wnt pathway activation with prechemotherapy abiraterone acetate resistance in metastatic castration-resistant prostate cancer (mCRPC) by genome-wide analysis of metastases. Journal of Clinical Oncology. 35: 175-175. DOI: 10.1200/Jco.2017.35.6_Suppl.175  0.358
2017 Kohli M, Li J, Du M, Hillman DW, Tan W, Carlson R, Wang L, Wang L, Liu MC, Zhang H, Zhang P, Wang L. Circulating tumor cells (CTCs) and plasma cell free DNA (cfDNA) androgen receptor amplification (ARamp)-based prognosis in metastatic castration-resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 35: 152-152. DOI: 10.1200/Jco.2017.35.6_Suppl.152  0.313
2017 Kohli M, Wang L, Dehm S, Hillman DW, Sicotte H, Gormley M, Bhargava V, Li W, Tan W, Pitot HC, Ho TH, Costello BA, Bryce AH, Zhenqing Y, Vedell PT, ... ... Wang L, et al. Genome-wide analysis of metastases to reveal association of pathway activation with abiraterone acetate/prednisone (AA/P) primary resistance and cell cycle proliferation pathway activation with response duration in metastatic castrate resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 35: 5053-5053. DOI: 10.1200/Jco.2017.35.15_Suppl.5053  0.368
2017 Ku KP, Lang JM, Sperger J, Dehm S, Kohli M, Wang L, Wang L, Tagawa ST, Scher HI. Trop-2 expression on treatment resistant cancer cells in castrate-resistant prostate cancer (CRPC) as a predictive biomarker for targeted therapy. Journal of Clinical Oncology. 35: 5045-5045. DOI: 10.1200/Jco.2017.35.15_Suppl.5045  0.38
2017 Kohli M, Ho Y, Hillman DW, Etten JLV, Henzler C, Yang R, Li Y, Tseng E, Hon T, Clark TA, Wang L, Silverstein K, Wang L, Dehm SM. Abstract 425: SMRT® Sequencing of full-length androgen receptor isoforms in prostate cancer reveals previously hidden drug resistant variants Cancer Research. 77: 425-425. DOI: 10.1158/1538-7445.Am2017-425  0.326
2017 Huang C, Du M, Wang L, Lin Y, Huang H, Wang L, Wang L, Kohli M. Abstract 2733: Comparison of copy number aberrations (CNAs) between plasma cell free DNA (cfDNA) and tissue DNA in metastatic castrate resistant prostate cancer (mCRPC) Cancer Research. 77: 2733-2733. DOI: 10.1158/1538-7445.Am2017-2733  0.309
2016 Niu N, Liu T, Cairns J, Ly RC, Tan X, Deng M, Fridley BL, Kalari KR, Abo RP, Jenkins G, Batzler A, Carlson EE, Barman P, Moran S, Heyn H, ... ... Wang L, et al. Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines. Human Molecular Genetics. 25: 4819-4834. PMID 28173075 DOI: 10.1093/Hmg/Ddw301  0.36
2016 Nair AA, Niu N, Tang X, Thompson KJ, Wang L, Kocher JP, Subramanian S, Kalari KR. Circular RNAs and their associations with breast cancer subtypes. Oncotarget. PMID 27829232 DOI: 10.18632/Oncotarget.13134  0.414
2016 Ingle JN, Xie F, Ellis MJ, Goss PE, Shepherd LE, Chapman JW, Chen BE, Kubo M, Furukawa Y, Momozawa Y, Stearns V, Pritchard KI, Barman P, Carlson EE, Goetz MP, ... ... Wang L, et al. Genetic polymorphisms in the long noncoding RNA MIR2052HG offer a pharmacogenomic basis for the response of breast cancer patients to aromatase inhibitor therapy. Cancer Research. PMID 27758888 DOI: 10.1158/0008-5472.Can-16-1371  0.481
2016 Li L, Zhang JW, Jenkins G, Xie F, Carlson EE, Fridley BL, Bamlet WR, Petersen GM, McWilliams RR, Wang L. Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer. Pharmacogenetics and Genomics. PMID 27749787 DOI: 10.1097/Fpc.0000000000000241  0.385
2016 Niu N, Liu T, Cairns J, Ly RC, Tan X, Deng M, Fridley BL, Kalari KR, Abo RP, Jenkins G, Batzler A, Carlson EE, Barman P, Moran S, Heyn H, ... ... Wang L, et al. Metformin Pharmacogenomics: A genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines. Human Molecular Genetics. PMID 27616566 DOI: 10.1093/hmg/ddw301  0.36
2016 Park JH, Jang M, Tarhan YE, Katagiri T, Sasa M, Miyoshi Y, Kalari KR, Suman VJ, Weinshilboum R, Wang L, Boughey JC, Goetz MP, Nakamura Y. Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. International Journal of Oncology. PMID 27278091 DOI: 10.3892/Ijo.2016.3540  0.366
2016 Hart SN, Ellingson MS, Schahl K, Vedell PT, Carlson RE, Sinnwell JP, Barman P, Sicotte H, Eckel-Passow JE, Wang L, Kalari KR, Qin R, Kruisselbrink TM, Jimenez RE, Bryce AH, ... ... Wang L, et al. Determining the frequency of pathogenic germline variants from exome sequencing in patients with castrate-resistant prostate cancer. Bmj Open. 6: e010332. PMID 27084275 DOI: 10.1136/Bmjopen-2015-010332  0.324
2016 Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo WV, Frye MA, Skime M, Jenkins GD, Batzler A, Kalari K, Matson W, Bhasin SS, Zhu H, Mushiroda T, ... ... Wang L, et al. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Molecular Psychiatry. PMID 26903268 DOI: 10.1038/Mp.2016.6  0.373
2016 Kohli M, Hillman DW, Carlson R, Wang L, Li Y, Tan W, Ho TH, Sicotte H, Wang L, Costello BA, Pitot HC, Quevedo F, Dronca RS, Moynihan TJ, Atwell TD, et al. Association of androgen receptor V9 (ARV9) mRNA expression in metastatic tissue with early resistance to pre-chemotherapy abiraterone acetate/prednisone (AA/P). Journal of Clinical Oncology. 34: 237-237. DOI: 10.1200/Jco.2016.34.2_Suppl.237  0.327
2016 Kohli M, Hillman DW, Wang L, Li Y, Sicotte H, Carlson R, Tan W, Wu K, Eiken PW, Jimenez RE, Cernigliaro J, Quevedo F, Costello BA, Pitot HC, Moynihan TJ, ... ... Wang L, et al. Association of androgen receptor variant 9 (AR-V9) mRNA expression levels in metastatic tissue with resistance to abiraterone acetate/prednisone (AA/P). Journal of Clinical Oncology. 34: 5036-5036. DOI: 10.1200/Jco.2016.34.15_Suppl.5036  0.339
2016 Xie F, Kohli M, Ping Y, Jimenez RE, Weinshilboum RM, Wang L. Abstract A05: Developing patient derived xenograft (PDX) models for metastatic castration resistant prostate cancer (CRPC) during CYP17 inhibitor therapy Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-A05  0.371
2016 Peddi P, Hurvitz S, Fasching P, Wang L, Cunningham J, Weinshilboum R, Liu D, Quinaux E, Fourmanoir H, Robert N, Valero V, Crown J, Falkson C, Brufsky A, Pienkowski T, et al. Abstract P6-03-09: Genetic polymorphism and correlation with treatment induced cardiotoxicity and prognosis inHER2amplified early breast cancer patients Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P6-03-09  0.309
2016 Ruddy K, Rack B, Schwitulla J, Lambrechts D, Haeberle L, Schramm A, Trapp E, Scholz C, Beutler A, Ginsburg E, Couch F, Partridge A, Wang L, Weinshilboum R, Janni W, et al. Abstract P4-10-07: Genetic predictors of chemotherapy-related amenorrhea Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P4-10-07  0.331
2016 Moyer A, Boughey J, Kalari K, Suman V, McLaughlin S, Moreno-Aspitia A, Northfelt D, Gray R, Sinnwell J, Carlson E, Dockter T, Jones K, Felten S, Conners A, Wieben E, ... ... Wang L, et al. Abstract P4-04-05: Differential mRNA expression patterns in breast tumors with high vs. low quantity of stromal tumor–Infiltrating lymphocytes Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P4-04-05  0.316
2016 Yu J, Qin B, Boughey J, Moyer A, Visscher D, Sinnwell J, Yin P, Thompson K, Docter T, Kalari K, Suman V, Wieben E, Felten S, Conners A, Jones K, ... ... Wang L, et al. Abstract P3-07-51: Regulation of DNA methyltransferases via TRAF6 determines breast cancer response to decitabine Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-51  0.323
2015 Kohli M, Wang L, Xie F, Sicotte H, Yin P, Dehm SM, Hart SN, Vedell PT, Barman P, Qin R, Mahoney DW, Carlson RE, Eckel-Passow JE, Atwell TD, Eiken PW, ... ... Wang L, et al. Mutational Landscapes of Sequential Prostate Metastases and Matched Patient Derived Xenografts during Enzalutamide Therapy. Plos One. 10: e0145176. PMID 26695660 DOI: 10.1371/Journal.Pone.0145176  0.373
2015 Liu T, Fang Y, Zhang H, Deng M, Gao B, Niu N, Yu J, Lee S, Kim J, Qin B, Xie F, Evans DL, Wang L, Lou W, Lou Z. HEATR1 negatively regulates Akt to help sensitize pancreatic cancer cells to chemotherapy. Cancer Research. PMID 26676747 DOI: 10.1158/0008-5472.Can-15-0671  0.31
2015 Kim JJ, Lee SB, Jang J, Yi SY, Kim SH, Han SA, Lee JM, Tong SY, Vincelette ND, Gao B, Yin P, Evans D, Choi DW, Qin B, Liu T, ... ... Wang L, et al. WSB1 promotes tumor metastasis by inducing pVHL degradation. Genes & Development. 29: 2244-57. PMID 26545811 DOI: 10.1101/Gad.268128.115  0.323
2015 Hanson C, Cairns J, Wang L, Sinha S. Computational discovery of transcription factors associated with drug response. The Pharmacogenomics Journal. PMID 26503816 DOI: 10.1038/Tpj.2015.74  0.422
2015 Ellingson MS, Hart SN, Kalari KR, Suman V, Schahl KA, Dockter TJ, Felten SJ, Sinnwell JP, Thompson KJ, Tang X, Vedell PT, Barman P, Sicotte H, Eckel-Passow JE, Northfelt DW, ... ... Wang L, et al. Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy. Breast Cancer Research and Treatment. 153: 435-43. PMID 26296701 DOI: 10.1007/S10549-015-3545-6  0.368
2015 Hein A, Lambrechts D, von Minckwitz G, Häberle L, Eidtmann H, Tesch H, Untch M, Hilfrich J, Schem C, Rezai M, Gerber B, Dan Costa S, Blohmer JU, Schwedler K, Kittel K, ... ... Wang L, et al. Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study. International Journal of Cancer. Journal International Du Cancer. 137: 2981-8. PMID 26100253 DOI: 10.1002/ijc.29656  0.318
2015 Cairns J, Peng Y, Yee VC, Lou Z, Wang L. Bora downregulation results in radioresistance by promoting repair of double strand breaks. Plos One. 10: e0119208. PMID 25742493 DOI: 10.1371/Journal.Pone.0119208  0.335
2015 Qin B, Minter-Dykhouse K, Yu J, Zhang J, Liu T, Zhang H, Lee S, Kim J, Wang L, Lou Z. DBC1 functions as a tumor suppressor by regulating p53 stability. Cell Reports. 10: 1324-34. PMID 25732823 DOI: 10.1016/J.Celrep.2015.01.066  0.344
2015 Niu N, Wang L. In vitro human cell line models to predict clinical response to anticancer drugs. Pharmacogenomics. 16: 273-85. PMID 25712190 DOI: 10.2217/Pgs.14.170  0.337
2015 Vachon CM, Schaid DJ, Ingle JN, Wickerham DL, Kubo M, Mushiroda T, Goetz MP, Carlson EE, Paik S, Wolmark N, Nakamura Y, Wang L, Weinshilboum R, Couch FJ. A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2. Breast Cancer Research and Treatment. 149: 517-23. PMID 25575444 DOI: 10.1007/S10549-014-3175-4  0.38
2015 Jimenez RE, Sicotte H, Barman P, Sinnwell JP, Eiken PW, Atwell TD, McMenomy BP, Tan W, Wu K, Bryce AH, Ho TH, Pitot HC, Quevedo F, Costello BA, Dronca RS, ... ... Wang L, et al. Feasibility analysis of pathology and genetic yield from a prospective trial of tissue biopsies in metastatic castrate-resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 33: 249-249. DOI: 10.1200/Jco.2015.33.7_Suppl.249  0.305
2015 Kohli M, Wang L, Sicotte H, Qin R, Carlson R, Eckel-Passow J, Tan W, Wu K, Dehm S, Eiken PW, Jimenez RE, Cernigliaro J, Quevedo F, Costello BA, Pitot HC, ... ... Wang L, et al. Androgen receptor (AR) based biomarker association with response to abiraterone acetate/prednisone (AA/P) in metastatic castrate resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 33: 174-174. DOI: 10.1200/Jco.2015.33.7_Suppl.174  0.356
2015 Kohli M, Qin R, Wang L, Sicotte H, Carlson R, Tan W, Jimenez RE, Wang L, Eckel-Passow J, Costello BA, Pitot HC, Quevedo F, Dronca RS, Wu K, Moynihan TJ, et al. A molecular and clinico-pathological model for predicting abiraterone acetate/prednisone (AA/P) efficacy in metastatic castrate resistant prostate cancer (mCRPC). Journal of Clinical Oncology. 33: 5056-5056. DOI: 10.1200/Jco.2015.33.15_Suppl.5056  0.335
2015 Goetz MP, Barrett MT, Kalari KR, Suman VJ, McLaughlin SA, Moreno-Aspitia A, Moyer AM, Northfelt DW, Gray RJ, Sinnwell J, Mahoney D, Barman P, Vedell P, Tang X, Thompson K, ... ... Wang L, et al. Abstract PD3-3: Impact of neoadjuvant chemotherapy on the clonal composition of breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-Pd3-3  0.427
2015 Vachon CM, Schaid DJ, Ingle JN, Goetz MP, Wickerham DL, Kubo M, Carlson EE, Paik S, Wolmark N, Nakamura Y, Wang L, Weinshilboum RM, Couch FJ. Abstract P6-10-03: The contribution of common genetic variation to breast cancer risk among women receiving tamoxifen or raloxifene within the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 and P-2 trials Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-10-03  0.39
2015 Breitenstein MK, Ho M, Weinshilboum RM, Cerhan JR, Pathak J, Bongartz T, Wang L, Ingle JN. Abstract LB-191: Association of anti-estrogen therapy in breast cancer patients and subsequent risk of rheumatoid arthritis: An electronic health record study Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-191  0.338
2015 Bidadi B, Kalari KR, Rubner M, Hein A, Beckmann MW, Fasching PA, Rack B, Janni W, Weinshilboum R, Wang L. Abstract 5488: Utilizing a pathway based analysis of genome wide association data to identify biomarkers of toxicity in breast cancer patients Cancer Research. 75: 5488-5488. DOI: 10.1158/1538-7445.Am2015-5488  0.407
2015 Breitenstein MK, Slager SL, Novak AJ, Maurer MJ, Thompson CA, Farooq U, Link BK, Habermann TM, Olswold CL, Feldman AL, Nowakowski GS, Ansell SM, Witzig TE, Weinshilboum RM, Wang L, et al. Abstract B143: Pharmacogenomic of refractory response to R-CHOP therapy in diffuse large B-cell lymphoma (DLBCL) patients Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B143  0.348
2014 Tong Y, Niu N, Jenkins G, Batzler A, Li L, Kalari KR, Wang L. Identification of genetic variants or genes that are associated with Homoharringtonine (HHT) response through a genome-wide association study in human lymphoblastoid cell lines (LCLs). Frontiers in Genetics. 5: 465. PMID 25628645 DOI: 10.3389/Fgene.2014.00465  0.43
2014 Tang X, Baheti S, Shameer K, Thompson KJ, Wills Q, Niu N, Holcomb IN, Boutet SC, Ramakrishnan R, Kachergus JM, Kocher JP, Weinshilboum RM, Wang L, Thompson EA, Kalari KR. The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data. Nucleic Acids Research. 42: e172. PMID 25352556 DOI: 10.1093/Nar/Gku1005  0.386
2014 Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X. Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clinical Pharmacology and Therapeutics. 96: 609-15. PMID 25054431 DOI: 10.1038/Clpt.2014.154  0.392
2014 Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, et al. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. Plos Genetics. 10: e1004214. PMID 24651765 DOI: 10.1371/Journal.Pgen.1004214  0.339
2014 Zhou W, Lv R, Qi W, Wu D, Xu Y, Liu W, Mou Y, Wang L. Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer. Plos One. 9: e87409. PMID 24489910 DOI: 10.1371/Journal.Pone.0087409  0.342
2014 Li L, Fridley BL, Kalari K, Niu N, Jenkins G, Batzler A, Abo RP, Schaid D, Wang L. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines Bmc Genomics. 15. PMID 24483146 DOI: 10.1186/1471-2164-15-93  0.42
2014 Fridley BL, Abo R, Tan XL, Jenkins GD, Batzler A, Moyer AM, Biernacka JM, Wang L. Integrative gene set analysis: Application to platinum pharmacogenomics Omics a Journal of Integrative Biology. 18: 34-41. PMID 24199607 DOI: 10.1089/Omi.2013.0099  0.427
2014 Dudenkov TM, Ingle JN, Buzdar A, Robson ME, Kubo M, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Fridley BL, Goetz MP, Northfelt DW, Perez EA, Williard CV, Kalari KR, ... ... Wang L, et al. Genes associated with serum estrone, estrone conjugates, and androstenedione concentrations in postmenopausal women with estrogen receptor-positive breast cancer. Journal of Clinical Oncology. 32: 593-593. DOI: 10.1200/Jco.2014.32.15_Suppl.593  0.392
2014 Boughey JC, Yu J, Yin P, Gao B, Sinnwell JP, Moyer AM, Visscher DW, Conners AL, Dockter TJ, Kalari KR, Jones KN, McLaughlin SA, Copland JA, Moreno-Aspitia A, Northfelt DW, ... ... Wang L, et al. Patient-derived xenografts from breast cancer patients before and after neoadjuvant chemotherapy: A prospective study. Journal of Clinical Oncology. 32: 11130-11130. DOI: 10.1200/Jco.2014.32.15_Suppl.11130  0.381
2014 Thompson KJ, Tang X, Sun Z, Sinnwell JP, Sicotte H, Mahoney DW, Hart S, Vedell PT, Barman P, Passow JEE, Wieben ED, Ingle JN, Boughey JC, Wang L, Weinshilboum R, et al. Abstract 5592: Molecular classification of triple negative breast cancer via RNA-sequencing data Cancer Research. 74: 5592-5592. DOI: 10.1158/1538-7445.Am2014-5592  0.403
2014 Kalari KR, Tang X, Thompson KJ, Mahoney DW, Barman P, Sinnwell JP, Sicotte H, Vedell P, Hart SN, Dockter TJ, Jones KN, Conners AL, Moyer AM, Visscher DW, Yu J, ... ... Wang L, et al. Abstract 4185: Analysis of sequencing data to identify potential drug targets for an individual newly diagnosed with basal breast cancer who failed to respond to current standard neoadjuvant chemotherapy Cancer Research. 74: 4185-4185. DOI: 10.1158/1538-7445.Am2014-4185  0.431
2014 Hou J, Bhinge KN, Wang L. Abstract 2782: The effect of ERRFI1 as a novel AKT regulator on cell proliferation and response to therapy is cell context dependent Cancer Research. 74: 2782-2782. DOI: 10.1158/1538-7445.Am2014-2782  0.329
2014 Yu J, Yin P, Gao B, Sinnwell JP, Moyer AM, Visscher DW, Conners AL, Dockter TJ, Kalari KR, Tang X, Thompson KJ, Sicotte H, Mahoney DW, Hart SN, Vedell PT, ... ... Wang L, et al. Abstract 1195: Feasibility of using percutaneous tumor biopsies from a prospective neoadjuvant breast cancer study to develop patient derived xenografts and assessin vivochemotherapy sensitivity Cancer Research. 74: 1195-1195. DOI: 10.1158/1538-7445.Am2014-1195  0.368
2014 Ho M-, Liu M, Wang L, Weinshilboum R, Bongartz T. THU0481 Aromatase Inhibitor Treatment and Musculoskeletal Adverse Events: SNP Modulated, Estrogen-Dependent Variation in Ccr6/Ccl20 Expression Annals of the Rheumatic Diseases. 73: 349-349. DOI: 10.1136/Annrheumdis-2014-Eular.5382  0.404
2014 Ho M-, Wang L, Weinshilboum R, Bongartz T. OP0193 The Rheumatoid Arthritis -Risk Locus CCR6 and Its Snp-Dependent Response to Estrogen: A Possible Genomic Link between Sex Hormones and the IL-17 Inflammatory Pathway Annals of the Rheumatic Diseases. 73: 135-135. DOI: 10.1136/Annrheumdis-2014-Eular.5289  0.355
2013 Jiang J, Fridley BL, Feng Q, Abo RP, Brisbin A, Batzler A, Jenkins G, Long PA, Wang L. Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. Frontiers in Genetics. 4: 166. PMID 24009623 DOI: 10.3389/Fgene.2013.00166  0.432
2013 Ellsworth KA, Eckloff BW, Li L, Moon I, Fridley BL, Jenkins GD, Carlson E, Brisbin A, Abo R, Bamlet W, Petersen G, Wieben ED, Wang L. Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma. Plos One. 8: e70216. PMID 23936393 DOI: 10.1371/Journal.Pone.0070216  0.721
2013 Ingle JN, Liu M, Wickerham DL, Schaid DJ, Wang L, Mushiroda T, Kubo M, Costantino JP, Vogel VG, Paik S, Goetz MP, Ames MM, Jenkins GD, Batzler A, Carlson EE, et al. Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention. Cancer Discovery. 3: 812-25. PMID 23764426 DOI: 10.1158/2159-8290.Cd-13-0038  0.436
2013 Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, et al. TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. Molecular Endocrinology (Baltimore, Md.). 27: 657-70. PMID 23518928 DOI: 10.1210/Me.2012-1397  0.453
2013 Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A, Biernacka JM, Abo R, Brisbin A, Ji Y, Hebbring S, Wieben ED, Mrazek DA, Weinshilboum RM, Wang L. FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder. Pharmacogenetics and Genomics. 23: 156-66. PMID 23324805 DOI: 10.1097/Fpc.0B013E32835Dc133  0.743
2013 Pu X, Wang L, Hildebrandt MA, Ye Y, Chang JY, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X. Abstract 3626: Inflammation-related genetic variants predict radiation-induced toxicity following definitive radiotherapy for non-small cell lung cancer. Cancer Research. 73: 3626-3626. DOI: 10.1158/1538-7445.Am2013-3626  0.422
2013 Niu N, Tan X, Fridley BL, Schaid DJ, Abo RP, Batzler A, Carlson EE, Jenkins G, Moran S, Heyn HA, Badosa ME, Wang L. Abstract 2271: Metformin pharmacogenomics: A genome-wide associate study to identify genetic and epigenetic biomarkers involved in metformin response. Cancer Research. 73: 2271-2271. DOI: 10.1158/1538-7445.Am2013-2271  0.473
2013 Ellsworth KA, Eckloff BW, Li L, Moon I, Fridley BL, Jenkins GD, Carlson E, Brisbin A, Abo R, Bamlet W, Petersen G, Wieben ED, Wang L. Abstract 2209: Contribution ofFKBP5genetic variation to gemcitabine treatment and survival in pancreatic cancer. Cancer Research. 73: 2209-2209. DOI: 10.1158/1538-7445.Am2013-2209  0.761
2013 Goetz M, Boughey J, Kalari K, Eckel-Passow J, Suman V, Sicotte H, Hart S, Moyer A, Visscher D, Yu J, Gao B, Sinnwell J, Mahoney D, Barman P, Vedell P, ... ... Wang L, et al. Abstract P1-08-10: Integration of next generation sequencing (NGS) and patient derived xenografts (PDX) to identify novel markers of paclitaxel (T) response in the breast cancer genome guided therapy study (BEAUTY) Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-P1-08-10  0.324
2012 Niu N, Schaid DJ, Abo RP, Kalari K, Fridley BL, Feng Q, Jenkins G, Batzler A, Brisbin AG, Cunningham JM, Li L, Sun Z, Yang P, Wang L. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. Bmc Cancer. 12: 422. PMID 23006423 DOI: 10.1186/1471-2407-12-422  0.431
2012 Brisbin A, Jenkins GD, Ellsworth KA, Wang L, Fridley BL. Localization of association signal from risk and protective variants in sequencing studies. Frontiers in Genetics. 3: 173. PMID 22973297 DOI: 10.3389/Fgene.2012.00173  0.705
2012 Hou J, Wang L. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. Plos One. 7: e36252. PMID 22590527 DOI: 10.1371/Journal.Pone.0036252  0.351
2012 Breheny P, Chalise P, Batzler A, Wang L, Fridley BL. Genetic association studies of copy-number variation: should assignment of copy number states precede testing? Plos One. 7: e34262. PMID 22493684 DOI: 10.1371/Journal.Pone.0034262  0.364
2012 Fridley BL, Lund S, Jenkins GD, Wang L. A Bayesian integrative genomic model for pathway analysis of complex traits. Genetic Epidemiology. 36: 352-9. PMID 22460780 DOI: 10.1002/Gepi.21628  0.321
2012 Liu M, Wang L, Bongartz T, Hawse JR, Markovic SN, Schaid DJ, Mushiroda T, Kubo M, Nakamura Y, Kamatani N, Goss PE, Ingle JN, Weinshilboum RM. Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Breast Cancer Research : Bcr. 14: R41. PMID 22405131 DOI: 10.1186/bcr3137  0.303
2012 Biernacka JM, Jenkins GD, Wang L, Moyer AM, Fridley BL. Use of the gamma method for self-contained gene-set analysis of SNP data. European Journal of Human Genetics : Ejhg. 20: 565-71. PMID 22166939 DOI: 10.1038/Ejhg.2011.236  0.374
2012 Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, et al. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 577-84. PMID 22142827 DOI: 10.1158/1078-0432.Ccr-11-1387  0.387
2011 Fridley BL, Batzler A, Li L, Li F, Matimba A, Jenkins GD, Ji Y, Wang L, Weinshilboum RM. Gene set analysis of purine and pyrimidine antimetabolites cancer therapies. Pharmacogenetics and Genomics. 21: 701-12. PMID 21869733 DOI: 10.1097/Fpc.0B013E32834A48A9  0.325
2011 Tan XL, Moyer AM, Fridley BL, Schaid DJ, Niu N, Batzler AJ, Jenkins GD, Abo RP, Li L, Cunningham JM, Sun Z, Yang P, Wang L. Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5801-11. PMID 21775533 DOI: 10.1158/1078-0432.Ccr-11-1133  0.319
2011 Li Y, Sun Z, Cunningham JM, Aubry MC, Wampfler JA, Croghan GA, Johnson C, Wu D, Aakre JA, Molina J, Wang L, Pankratz VS, Yang P. Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3830-40. PMID 21636554 DOI: 10.1158/1078-0432.CCR-10-2877  0.374
2011 Wu TY, Fridley BL, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen. International Immunopharmacology. 11: 1057-64. PMID 21396482 DOI: 10.1016/J.Intimp.2011.02.027  0.402
2011 Lobmeyer MT, Wang L, Zineh I, Turner ST, Gums JG, Chapman AB, Cooper-DeHoff RM, Beitelshees AL, Bailey KR, Boerwinkle E, Pepine CJ, Johnson JA. Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients. Pharmacogenetics and Genomics. 21: 42-9. PMID 21127457 DOI: 10.1097/Fpc.0B013E328341E911  0.342
2011 Li L, Lou Z, Wang L. The role of FKBP5 in cancer aetiology and chemoresistance British Journal of Cancer. 104: 19-23. PMID 21119664 DOI: 10.1038/Sj.Bjc.6606014  0.305
2011 Liu M, Wang L, Schaid D, Wickerham DL, Costantino JP, Goetz MP, Ames MM, Vogel VG, Paik S, Batzler A, Wolmark N, Nakamura Y, Kubo M, Kamatani N, Ingle JN, et al. Abstract 4727: Breast cancer prevention and selective estrogen response modulators (SERMs): Pharmacogenomics and differential estrogen and SERM regulation of BRCA1 and BRCA2 expression Cancer Research. 71: 4727-4727. DOI: 10.1158/1538-7445.Am2011-4727  0.476
2011 Hou J, Qin B, Lou Z, Wang L. Abstract 2660: Downregulation of Bora gene expression in human tumor cells results in radioresistance by promoting repair of double strand breaks Cancer Research. 71: 2660-2660. DOI: 10.1158/1538-7445.Am2011-2660  0.365
2011 Tan X, Moyer AM, Schaid DJ, Niu N, Batzler A, Li L, Sun Z, Yang P, Wang L. Abstract 1285: Genetic variations predicting cisplatin cytotoxicity associated with the overall survival in lung cancer patients receiving platinum-based chemotherapy Cancer Research. 71: 1285-1285. DOI: 10.1158/1538-7445.Am2011-1285  0.436
2011 Hou J, Wang L. Abstract C15: Combined blockade of AKT kinase with gemcitabine overcomes FKBP5-mediated resistance of inhibition of pancreatic tumor growth. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C15  0.348
2011 Ibrahim-zada I, Ingle JN, Fridley BL, Buzdar A, Robson ME, Kubo M, Batzler A, Jenkins GD, Goetz MP, Northfelt DW, Perez EA, Williard CV, Wang L, Schaid DJ, Nakamura Y, et al. Abstract C114: Androstenedione levels in postmenopausal women with resected early-stage breast cancer are associated with SNPs in CYP11B1 and CYP11B2 identified by a genome-wide association study (GWAS). Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C114  0.418
2010 Niu N, Qin Y, Fridley BL, Hou J, Kalari KR, Zhu M, Wu TY, Jenkins GD, Batzler A, Wang L. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Research. 20: 1482-92. PMID 20923822 DOI: 10.1101/Gr.107672.110  0.398
2010 Ingle JN, Schaid DJ, Goss PE, Liu M, Mushiroda T, Chapman JA, Kubo M, Jenkins GD, Batzler A, Shepherd L, Pater J, Wang L, Ellis MJ, Stearns V, Rohrer DC, et al. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 4674-82. PMID 20876420 DOI: 10.1200/Jco.2010.28.5064  0.396
2010 Li F, Fridley BL, Matimba A, Kalari KR, Pelleymounter L, Moon I, Ji Y, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 2329-38. PMID 20855458 DOI: 10.1124/Dmd.110.035220  0.419
2010 Kalari KR, Hebbring SJ, Chai HS, Li L, Kocher JP, Wang L, Weinshilboum RM. Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach. Bmc Genomics. 11: 357. PMID 20525348 DOI: 10.1186/1471-2164-11-357  0.454
2010 Wang L, Ellsworth KA, Moon I, Pelleymounter LL, Eckloff BW, Martin YN, Fridley BL, Jenkins GD, Batzler A, Suman VJ, Ravi S, Dixon JM, Miller WR, Wieben ED, Buzdar A, et al. Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors. Cancer Research. 70: 319-28. PMID 20048079 DOI: 10.1158/0008-5472.Can-09-3224  0.762
2010 Hou J, Niu N, Qin Y, Fridley BL, Kalari K, Jenkins G, Batzler A, Wang L. Abstract 3602: Radiation pharmacogenomics: an integrative analysis approach to identify biomarkers using the human lymphoblastoid cell lines Cancer Research. 70: 3602-3602. DOI: 10.1158/1538-7445.Am10-3602  0.415
2010 Niu N, Fridley BL, Kalari KR, Jenkins GD, Anthony B, Wang L. Abstract 2599: Taxane pharmacogenomics: Identifying genetic variation associated with drug cytotoxicity using a genome-wide association approach and a cell line model system Cancer Research. 70: 2599-2599. DOI: 10.1158/1538-7445.Am10-2599  0.469
2010 Ingle J, Liu M, Wickerham D, Schaid D, Mushiroda T, Kubo M, Costantino J, Goetz M, Ames M, Wang L, Vogel V, Paik S, Batzler A, Flockhart D, Wolmark N, et al. Abstract PD05-02: Genome-Wide Associations of Breast Events and Functional Genomic Studies in High-Risk Women Receiving Tamoxifen or Raloxifene on NSABP P1 and P2 Prevention Trials. A Pharmacogenomics Research Network-RIKEN-NSABP Collaboration Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-Pd05-02  0.321
2009 Li L, Fridley BL, Kalari K, Jenkins G, Batzler A, Weinshilboum RM, Wang L. Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers. Plos One. 4: e7765. PMID 19898621 DOI: 10.1371/Journal.Pone.0007765  0.332
2009 Aksoy P, Zhu MJ, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Yee VC, Weinshilboum RM, Wang L. Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics. Pharmacogenetics and Genomics. 19: 567-76. PMID 19623099 DOI: 10.1097/Fpc.0B013E32832C14B8  0.356
2009 Fridley BL, Jenkins G, Schaid DJ, Wang L. A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity. Statistics in Medicine. 28: 2709-22. PMID 19572260 DOI: 10.1002/Sim.3649  0.344
2008 Wang L, Weinshilboum RM. Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Human Molecular Genetics. 17: R174-9. PMID 18852207 DOI: 10.1093/Hmg/Ddn270  0.363
2008 Li L, Fridley B, Kalari K, Jenkins G, Batzler A, Safgren S, Hildebrandt M, Ames M, Schaid D, Wang L. Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Research. 68: 7050-8. PMID 18757419 DOI: 10.1158/0008-5472.Can-08-0405  0.403
2008 Ji Y, Olson J, Zhang J, Hildebrandt M, Wang L, Ingle J, Fredericksen Z, Sellers T, Miller W, Dixon JM, Brauch H, Eichelbaum M, Justenhoven C, Hamann U, Ko Y, et al. Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms. Cancer Research. 68: 5997-6005. PMID 18632656 DOI: 10.1158/0008-5472.Can-08-0043  0.44
2008 Wang L, Kumar S, Fridley BL, Kalari KR, Moon I, Pelleymounter LL, Hildebrandt MA, Batzler A, Eckloff BW, Wieben ED, Greipp PR. Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3503-13. PMID 18519783 DOI: 10.1158/1078-0432.Ccr-07-5150  0.321
2007 Wang L, Salavaggione E, Pelleymounter L, Eckloff B, Wieben E, Weinshilboum R. Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics. The Journal of Steroid Biochemistry and Molecular Biology. 107: 88-99. PMID 17689071 DOI: 10.1016/J.Jsbmb.2007.03.037  0.398
2006 Weinshilboum RM, Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annual Review of Genomics and Human Genetics. 7: 223-45. PMID 16948615 DOI: 10.1146/Annurev.Genom.6.080604.162315  0.325
2006 Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM. Human arsenic methyltransferase (AS3MT) pharmacogenetics: Gene resequencing and functional genomics studies Journal of Biological Chemistry. 281: 7364-7373. PMID 16407288 DOI: 10.1074/Jbc.M512227200  0.363
2005 Ma CX, Adjei AA, Salavaggione OE, Coronel J, Pelleymounter L, Wang L, Eckloff BW, Schaid D, Wieben ED, Adjei AA, Weinshilboum RM. Human aromatase: gene resequencing and functional genomics. Cancer Research. 65: 11071-82. PMID 16322257 DOI: 10.1158/0008-5472.Can-05-1218  0.418
2005 Ji Y, Salavaggione OE, Wang L, Adjei AA, Eckloff B, Wieben ED, Weinshilboum RM. Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. Journal of Neurochemistry. 95: 1766-76. PMID 16277617 DOI: 10.1111/J.1471-4159.2005.03453.X  0.387
2005 Salavaggione OE, Wang L, Wiepert M, Yee VC, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics. Pharmacogenetics and Genomics. 15: 801-15. PMID 16220112 DOI: 10.1097/01.Fpc.0000174788.69991.6B  0.341
2005 Wang L, Nguyen TV, McLaughlin RW, Sikkink LA, Ramirez-Alvarado M, Weinshilboum RM. Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9394-9. PMID 15967990 DOI: 10.1073/Pnas.0502352102  0.331
2005 MA C, ADJEI A, SALAVAGGIONE O, WANG L, ECKLOFF B, WIEBEN E, ADJEI A, WEINSHILBOUM R. Human aromatase (CYP19) pharmacogenomics: Gene resequencing and functional genomics Clinical Pharmacology & Therapeutics. 77: P22-P22. DOI: 10.1016/J.Clpt.2004.11.085  0.446
2002 Salavaggione OE, Kidd L, Prondzinski JL, Szumlanski CL, Pankratz VS, Wang L, Trepanier L, Weinshilboum RM. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics. 12: 713-24. PMID 12464800 DOI: 10.1097/00008571-200212000-00005  0.389
2002 Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: Gene resequencing, promoter characterization, and functional studies of a common 5′-flanking region single nucleotide polymorphism (SNP) Biochemical Pharmacology. 64: 699-710. PMID 12167489 DOI: 10.1016/S0006-2952(02)01223-6  0.407
Low-probability matches (unlikely to be authored by this person)
2019 Athreya AP, Neavin D, Carrillo-Roa T, Skime M, Biernacka J, Frye MA, Rush AJ, Wang L, Binder EB, Iyer RK, Weinshilboum RM, Bobo WV. Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine Learning Approach with Multi-Trial Replication. Clinical Pharmacology and Therapeutics. PMID 31012492 DOI: 10.1002/Cpt.1482  0.298
2004 Weinshilboum R, Wang L. Pharmacogenomics: Bench to bedside Nature Reviews Drug Discovery. 3: 739-748. PMID 15340384 DOI: 10.1038/Nrd1497  0.298
2019 Steele TM, Jathal MK, Siddiqui S, Qin S, Tepper CG, White RWd, Kohli M, Wang L, Gao AC, Ghosh PM. Abstract 4842: Overcoming EGFR and ERK-mediated resistance to enzalutamide in castration-resistant prostate cancer Cancer Research. 79: 4842-4842. DOI: 10.1158/1538-7445.Am2019-4842  0.297
2020 Morales-Rosado JA, Goel K, Zhang L, Åkerblom A, Baheti S, Black JL, Eriksson N, Wallentin L, James S, Storey RF, Goodman SG, Jenkins GD, Eckloff BW, Bielinski SJ, Sicotte H, ... ... Wang L, et al. Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics. Cardiovascular Drugs and Therapy. PMID 32623598 DOI: 10.1007/S10557-020-06988-W  0.295
2022 Peddi PF, Fasching PA, Liu D, Quinaux E, Robert NJ, Valero V, Crown J, Falkson C, Brufsky A, Cunningham JM, Weinshilboum RM, Pienkowski T, Eiermann W, Martín M, Bee V, ... ... Wang L, et al. Genetic polymorphisms and correlation with treatment induced cardiotoxicity and prognosis in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35110416 DOI: 10.1158/1078-0432.CCR-21-1762  0.295
2021 He Y, Wang L, Wei T, Xiao YT, Sheng H, Su H, Hollern DP, Zhang X, Ma J, Wen S, Xie H, Yan Y, Pan Y, Hou X, Tang X, ... ... Wang L, et al. FOXA1 overexpression suppresses interferon signaling and immune response in cancer. The Journal of Clinical Investigation. PMID 34101624 DOI: 10.1172/JCI147025  0.294
2020 Swanson KM, Zhu Y, Rojas RL, St Sauver JL, Bielinski SJ, Jacobsen DJ, Visscher SL, Wang L, Weinshilboum R, Borah BJ. Comparing outcomes and costs among warfarin-sensitive patients versus warfarin-insensitive patients using The Right Drug, Right Dose, Right Time: Using genomic data to individualize treatment (RIGHT) 10K warfarin cohort. Plos One. 15: e0233316. PMID 32428022 DOI: 10.1371/Journal.Pone.0233316  0.293
2020 Blatti C, Emad A, Berry MJ, Gatzke L, Epstein M, Lanier D, Rizal P, Ge J, Liao X, Sobh O, Lambert M, Post CS, Xiao J, Groves P, Epstein AT, ... ... Wang L, et al. Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform. Plos Biology. 18: e3000583. PMID 31971940 DOI: 10.1371/Journal.Pbio.3000583  0.293
2019 Vu TN, Nguyen HN, Calza S, Kalari KR, Wang L, Pawitan Y. Cell-level somatic mutation detection from single-cell RNA-sequencing. Bioinformatics (Oxford, England). PMID 31028395 DOI: 10.1093/Bioinformatics/Btz288  0.292
2011 Rudin D, Li L, Niu N, Kalari KR, Gilbert JA, Ames MM, Wang L. Gemcitabine Cytotoxicity: Interaction of Efflux and Deamination. Journal of Drug Metabolism & Toxicology. 2: 1-10. PMID 21804948 DOI: 10.4172/2157-7609.1000107  0.29
2019 Bhattacharyya S, Ahmed AT, Arnold M, Liu D, Luo C, Zhu H, Mahmoudiandehkordi S, Neavin D, Louie G, Dunlop BW, Frye MA, Wang L, Weinshilboum RM, Krishnan RR, Rush AJ, et al. Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients. Translational Psychiatry. 9: 173. PMID 31273200 DOI: 10.1038/S41398-019-0507-5  0.29
2019 Jimenez RE, Atwell TD, Sicotte H, Eckloff B, Wang L, Barman P, Sinnwell JP, Eiken PW, McMenomy BP, Tan W, Wang L, Carlson RE, Kohli M. A Prospective Correlation of Tissue Histopathology With Nucleic Acid Yield in Metastatic Castration-Resistant Prostate Cancer Biopsy Specimens. Mayo Clinic Proceedings. Innovations, Quality & Outcomes. 3: 14-22. PMID 30899904 DOI: 10.1016/J.Mayocpiqo.2018.12.005  0.289
2017 Wang L, Ingle J, Weinshilboum R. Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study. Clinical Pharmacology and Therapeutics. PMID 29052219 DOI: 10.1002/cpt.915  0.288
2020 Sullivan CCO, Kalari KR, Suman VJ, Vedell PT, Moyer A, Carlson E, Sinnwell J, Alaparthi T, Tang X, Thompson K, Sung J, Moreno-Aspitia A, Northfelt D, Liu MC, Haddad TC, ... ... Wang L, et al. Abstract P2-11-07: Comprehensive tumor sequencing to identify biomarkers of palbociclib response: First report of the PROMISE study Cancer Research. DOI: 10.1158/1538-7445.Sabcs19-P2-11-07  0.288
2016 Ho MF, Bongartz T, Liu M, Kalari KR, Goss PE, Shepherd LE, Goetz MP, Kubo M, Ingle JN, Wang L, Weinshilboum RM. Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation. Molecular Endocrinology (Baltimore, Md.). me20151267. PMID 26866883 DOI: 10.1210/me.2015-1267  0.287
2023 Zhang C, Guo Q, Chen L, Wu Z, Yan XJ, Zou C, Zhang Q, Tan J, Fang T, Rao Q, Li Y, Shen S, Deng M, Wang L, Gao H, et al. A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors. Signal Transduction and Targeted Therapy. 8: 183. PMID 37160887 DOI: 10.1038/s41392-023-01401-y  0.287
2015 Ellingson MS, Hart SN, Kalari KR, Suman V, Schahl KA, Dockter TJ, Felten SJ, Sinnwell JP, Thompson KJ, Tang X, Vedell PT, Barman P, Sicotte H, Eckel-Passow JE, Northfelt DW, ... ... Wang L, et al. Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy Breast Cancer Research and Treatment. DOI: 10.1007/s10549-015-3545-6  0.287
2014 Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Connelly JJ, Lillard TS, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, et al. Correction to Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke (PLoS Genet, (2014), 10, 7 (e1004571), 10.1371/journal.pgen.1004571) Plos Genetics. 10. DOI: 10.1371/Journal.Pgen.1004571  0.286
2014 Liu M, Goss PE, Ingle JN, Kubo M, Furukawa Y, Batzler A, Jenkins GD, Carlson EE, Nakamura Y, Schaid DJ, Chapman JA, Shepherd LE, Ellis MJ, Khosla S, Wang L, et al. Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics. Molecular Endocrinology (Baltimore, Md.). 28: 1740-51. PMID 25148458 DOI: 10.1210/me.2014-1147  0.286
2017 Thompson KJ, Ingle JN, Tang X, Chia N, Jeraldo PR, Walther-Antonio MR, Kandimalla KK, Johnson S, Yao JZ, Harrington SC, Suman VJ, Wang L, Weinshilboum RL, Boughey JC, Kocher JP, et al. A comprehensive analysis of breast cancer microbiota and host gene expression. Plos One. 12: e0188873. PMID 29190829 DOI: 10.1371/Journal.Pone.0188873  0.285
2018 Hanson C, Cairns J, Wang L, Sinha S. Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation. Genome Research. PMID 29898900 DOI: 10.1101/Gr.227066.117  0.284
2018 Liu D, Qin S, Ray B, Kalari KR, Wang L, Weinshilboum RM. Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent Induction. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29980579 DOI: 10.1124/dmd.118.082164  0.283
2022 Qin S, Gao H, Kim W, Zhang H, Gu Y, Kalari KR, Sinnwell JP, Scholz JA, Xie F, Yin P, Yu J, Qin B, Zhuang Y, Wei L, Tan W, ... ... Wang L, et al. Biomarkers for predicting abiraterone treatment outcome and selecting alternative therapies in castration-resistant prostate cancer. Clinical Pharmacology and Therapeutics. PMID 35288936 DOI: 10.1002/cpt.2582  0.282
2012 Li L, Schaid DJ, Fridley BL, Kalari KR, Jenkins GD, Abo RP, Batzler A, Moon I, Pelleymounter L, Eckloff BW, Wieben ED, Sun Z, Yang P, Wang L. Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer. Pharmacogenetics and Genomics. 22: 105-16. PMID 22173087 DOI: 10.1097/Fpc.0B013E32834Dd7E2  0.282
2022 Sicotte H, Kalari KR, Qin S, Dehm SM, Bhargava V, Gormley M, Tan W, Sinnwell JP, Hillman DW, Li Y, Vedell PT, Carlson RE, Bryce AH, Jimenez RE, Weinshilboum RM, ... ... Wang L, et al. Molecular profile changes in castrate resistant prostate cancer patients pre and post-abiraterone/prednisone treatment. Molecular Cancer Research : McR. PMID 36135372 DOI: 10.1158/1541-7786.MCR-22-0099  0.281
2020 Leon-Ferre RA, McGrath K, Suman VJ, Carter JM, Kalari KR, Weinshilboum RM, Wang L, Ingle JN, Knutson KL, Ansell SM, Boughey JC, Villasboas JC, Goetz MP. Liquid biopsy of the immune environment: Evaluation of peripheral blood mononuclear cells (PBMCs) with CyTOF and response to trastuzumab (T)-based neoadjuvant chemotherapy (NAC) in HER2+ breast cancer (BC). Journal of Clinical Oncology. 38: 592-592. DOI: 10.1200/Jco.2020.38.15_Suppl.592  0.281
2001 Wang L, Yan L, McGuire C, Kozak CA, Wang M, Kim UJ, Siciliano M, Weinshilboum RM. Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 50: 300-8. PMID 11475331 DOI: 10.1007/Pl00000248  0.277
2015 Kohli M, Eiken PW, McMenomy BP, Atwell TD, Tan W, Qin R, Carlson R, Campion MB, Wang L, Costello BA, Pitot HC, Quevedo F, Scheel EA, Ho TH, Bryce AH, et al. Effect of metastatic site biopsy on circulating tumor cell (CTC) count in castrate resistant prostate cancer (CRPC) stage. Journal of Clinical Oncology. 33: 190-190. DOI: 10.1200/Jco.2015.33.7_Suppl.190  0.277
2019 Moyer AM, Yu J, Sinnwell JP, Dockter TJ, Suman VJ, Weinshilboum RM, Boughey JC, Goetz MP, Visscher DW, Wang L. Spontaneous murine tumors in the development of patient-derived xenografts: a potential pitfall. Oncotarget. 10: 3924-3930. PMID 31231469 DOI: 10.18632/Oncotarget.27001  0.276
2018 Athreya A, Iyer R, Neavin D, Wang L, Weinshilboum R, Kaddurah-Daouk R, Rush J, Frye M, Bobo W. Augmentation of Physician Assessments with Multi-Omics Enhances Predictability of Drug Response: A Case Study of Major Depressive Disorder. Ieee Computational Intelligence Magazine. 13: 20-31. PMID 30467458 DOI: 10.1109/Mci.2018.2840660  0.276
2021 Cairns J, Ingle JN, Kalari KR, Goetz MP, Weinshilboum RM, Gao H, Li H, Ghanat Bari M, Wang L. Anastrozole regulates fatty acid synthase in breast cancer. Molecular Cancer Therapeutics. PMID 34667110 DOI: 10.1158/1535-7163.MCT-21-0509  0.276
2018 Ahmed AT, Biernacka JM, Jenkins G, Rush AJ, Shinozaki G, Veldic M, Kung S, Bobo WV, Hall-Flavin DK, Weinshilboum RM, Wang L, Frye MA. Pharmacokinetic-Pharmacodynamic interaction associated with venlafaxine-XR remission in patients with major depressive disorder with history of citalopram / escitalopram treatment failure. Journal of Affective Disorders. 246: 62-68. PMID 30578947 DOI: 10.1016/J.Jad.2018.12.021  0.274
2021 Boughey JC, Suman VJ, Yu J, Santo K, Sinnwell JP, Carter JM, Kalari KR, Tang X, McLaughlin SA, Moreno-Aspitia A, Northfelt DW, Gray RJ, Hunt KN, Conners AL, Ingle JN, ... ... Wang L, et al. Patient Derived Xenograft Engraftment and Breast Cancer Outcomes in a Prospective Neoadjuvant Study (BEAUTY). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 34078650 DOI: 10.1158/1078-0432.CCR-21-0641  0.274
2014 Wang L, Weinshilboum R. Metformin pharmacogenomics: biomarkers to mechanisms. Diabetes. 63: 2609-10. PMID 25060891 DOI: 10.2337/Db14-0609  0.271
2016 Simha V, Qin S, Shah P, Smith BH, Kremers WK, Kushwaha S, Wang L, Pereira NL. Sirolimus Therapy Is Associated with Elevation in Circulating PCSK9 Levels in Cardiac Transplant Patients. Journal of Cardiovascular Translational Research. PMID 28028691 DOI: 10.1007/S12265-016-9719-8  0.271
2011 Wang L, McLeod HL, Weinshilboum RM. Genomics and drug response. The New England Journal of Medicine. 364: 1144-53. PMID 21428770 DOI: 10.1056/Nejmra1010600  0.27
2015 Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, ... Wang L, et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Molecular Cell. PMID 26387737 DOI: 10.1016/J.Molcel.2015.08.011  0.269
2018 Kalari KR, Sinnwell JP, Thompson KJ, Tang X, Carlson EE, Yu J, Vedell PT, Ingle JN, Weinshilboum RM, Boughey JC, Wang L, Goetz MP, Suman V. PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient. Jco Clinical Cancer Informatics. 1-11. PMID 30652605 DOI: 10.1200/CCI.18.00012  0.267
2018 Ho MF, Correia C, Ingle JN, Kaddurah-Daouk R, Wang L, Kaufmann SH, Weinshilboum RM. Ketamine and Ketamine Metabolites as Novel Estrogen Receptor Ligands: Induction of Cytochrome P450 and AMPA Glutamate Receptor Gene Expression. Biochemical Pharmacology. PMID 29621538 DOI: 10.1016/J.Bcp.2018.03.032  0.266
2022 Zhang H, Gao H, Gu Y, John A, Wei L, Huang M, Yu J, Adeosun AA, Weinshilboum RM, Wang L. 3D CRISPR screen in prostate cancer cells reveals PARP inhibitor sensitization through TBL1XR1-SMC3 interaction. Frontiers in Oncology. 12: 999302. PMID 36523978 DOI: 10.3389/fonc.2022.999302  0.266
2021 Stahlfeld C, Sperger J, Slovin SF, Tagawa ST, Kyriakopoulos C, Kohli M, Wang L, Wang L, Dehm S, Lang JM. TROP-2 co-expression with androgen receptor splice variants as a new therapeutic target in prostate cancer. Journal of Clinical Oncology. 39: 5060-5060. DOI: 10.1200/JCO.2021.39.15_SUPPL.5060  0.266
2015 Hein A, Lambrechts D, von Minckwitz G, Häberle L, Eidtmann H, Tesch H, Untch M, Hilfrich J, Schem C, Rezai M, Gerber B, Dan Costa S, Blohmer JU, Schwedler K, Kittel K, ... ... Wang L, et al. Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study International Journal of Cancer. DOI: 10.1002/ijc.29656  0.263
2020 Pereira NL, Farkouh ME, So D, Lennon R, Geller N, Mathew V, Bell M, Bae JH, Jeong MH, Chavez I, Gordon P, Abbott JD, Cagin C, Baudhuin L, Fu YP, ... ... Wang L, et al. Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial. Jama. 324: 761-771. PMID 32840598 DOI: 10.1001/Jama.2020.12443  0.263
2018 West DC, Kocherginsky M, Tonsing-Carter EY, Dolcen DN, Hosfield DJ, Lastra RR, Sinnwell JP, Thompson KJ, Bowie KR, Harkless RV, Skor MN, Pierce CF, Styke SC, Kim CR, de Wet L, ... ... Wang L, et al. Discovery of a glucocorticoid receptor (GR) activity signature using selective GR antagonism in ER-negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29636357 DOI: 10.1158/1078-0432.Ccr-17-2793  0.262
2023 Earl Hostallero D, Wei L, Wang L, Cairns J, Emad A. Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL. Genomics, Proteomics & Bioinformatics. PMID 36775056 DOI: 10.1016/j.gpb.2023.01.006  0.259
2023 Tang X, Thompson KJ, Kalari KR, Sinnwell JP, Suman VJ, Vedell PT, McLaughlin SA, Northfelt DW, Aspitia AM, Gray RJ, Carter JM, Weinshilboum R, Wang L, Boughey JC, Goetz MP. Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors. Breast Cancer Research : Bcr. 25: 57. PMID 37226243 DOI: 10.1186/s13058-023-01656-x  0.259
2011 Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 470: 124-8. PMID 21293379 DOI: 10.1038/Nature09658  0.259
2012 Abo R, Jenkins GD, Wang L, Fridley BL. Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG. Plos One. 7: e43301. PMID 22905253 DOI: 10.1371/Journal.Pone.0043301  0.256
2008 Li F, Wang L, Burgess RJ, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. Pharmacogenetics and Genomics. 18: 1083-94. PMID 18820593 DOI: 10.1097/Fpc.0B013E328313E03F  0.256
2021 Qin S, Ingle JN, Kim W, Gao H, Weinshilboum RM, Wang L. ZNF423 modulates the AMP-activated protein kinase pathway and metformin response in a single nucleotide polymorphisms, estrogen and selective estrogen receptor modulator dependent fashion. Pharmacogenetics and Genomics. PMID 34001842 DOI: 10.1097/FPC.0000000000000435  0.254
2019 Bielinski SJ, St Sauver JL, Olson JE, Larson NB, Black JL, Scherer SE, Bernard ME, Boerwinkle E, Borah BJ, Caraballo PJ, Curry TB, Doddapaneni H, Formea CM, Freimuth RR, Gibbs RA, ... ... Wang L, ... ... Wang L, et al. Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol). International Journal of Epidemiology. PMID 31378813 DOI: 10.1093/Ije/Dyz123  0.253
2022 Nguyen TTL, Liu D, Gao H, Ye Z, Lee JH, Wei L, Yu J, Zhang L, Wang L, Ordog T, Weinshilboum RM. Glucocorticoids mediate transcriptome-wide alternative polyadenylation: Potential mechanistic and clinical implications. Clinical and Translational Science. PMID 36128656 DOI: 10.1111/cts.13402  0.253
2022 Kohale IN, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey JC, Carter JM, Goetz MP, Wang L, White FM. Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer. Cancers. 14. PMID 36077757 DOI: 10.3390/cancers14174220  0.251
2016 Wang L, Nie J, Sicotte H, Li Y, Eckel-Passow JE, Dasari S, Vedell PT, Barman P, Wang L, Weinshiboum R, Jen J, Huang H, Kohli M, Kocher JP. Measure transcript integrity using RNA-seq data. Bmc Bioinformatics. 17: 58. PMID 26842848 DOI: 10.1186/S12859-016-0922-Z  0.251
2019 Deng W, Mou T, Niu N, Wang L, Pawitan Y, Vu TN. Alternating EM algorithm for a bilinear model in isoform quantification from RNA-seq data. Bioinformatics (Oxford, England). PMID 31400221 DOI: 10.1093/Bioinformatics/Btz640  0.25
2017 Lanz HL, Saleh A, Kramer B, Cairns J, Ng CP, Yu J, Trietsch SJ, Hankemeier T, Joore J, Vulto P, Weinshilboum R, Wang L. Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform. Bmc Cancer. 17: 709. PMID 29096610 DOI: 10.1186/s12885-017-3709-3  0.25
2016 Cairns J, Ung CY, da Rocha EL, Zhang C, Correia C, Weinshilboum R, Wang L, Li H. A network-based phenotype mapping approach to identify genes that modulate drug response phenotypes. Scientific Reports. 6: 37003. PMID 27841317 DOI: 10.1038/Srep37003  0.249
2018 Ho MF, Lummertz da Rocha E, Zhang C, Ingle J, Goss P, Shepherd L, Kubo M, Wang L, Li H, Weinshilboum R. TCL1A, a novel transcription factor and a co-regulator of NF-кB p65: SNP and estrogen-dependence. The Journal of Pharmacology and Experimental Therapeutics. PMID 29592948 DOI: 10.1124/jpet.118.247718  0.248
2022 Gu Y, Gao H, Zhang H, John A, Zhu X, Shivaram S, Yu J, Weinshilboum RM, Wang L. TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer. Oncogene. PMID 35864174 DOI: 10.1038/s41388-022-02415-6  0.248
2021 Jalalirad M, Haddad TC, Salisbury JL, Radisky D, Zhang M, Schroeder M, Tuma A, Leof E, Carter JM, Degnim AC, Boughey JC, Sarkaria J, Yu J, Wang L, Liu MC, et al. Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance. Oncogene. PMID 33674749 DOI: 10.1038/s41388-021-01711-x  0.247
2022 Shivaram S, Gao H, Qin S, Liu D, Weinshilboum RM, Wang L. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 36153008 DOI: 10.1124/dmd.122.000945  0.247
2020 Yu J, Qin B, Moyer AM, Nowsheen S, Tu X, Dong H, Boughey JC, Goetz MP, Weinshilboum R, Lou Z, Wang L. Regulation of sister chromatid cohesion by nuclear PD-L1. Cell Research. PMID 32350394 DOI: 10.1038/S41422-020-0315-8  0.246
2009 Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell. 16: 259-66. PMID 19732725 DOI: 10.1016/J.Ccr.2009.07.016  0.246
2022 Wei L, Gao H, Yu J, Zhang H, Nguyen TTL, Gu Y, Passow MR, Carter JM, Qin B, Boughey JC, Goetz MP, Weinshilboum RM, Ingle JN, Wang L. Pharmacological targeting of androgen receptor elicits context-specific effects in estrogen receptor-positive breast cancer. Cancer Research. PMID 36469363 DOI: 10.1158/0008-5472.CAN-22-1016  0.246
2019 O'Sullivan C, Suman V, Kalari K, Moyer A, Sung J, Moreno-Aspitia A, Northfelt D, Liu M, Haddad T, Chumsri S, Couch F, Weinshilboum R, Wang L, Goetz M. Abstract OT3-02-08: Genetic analysis in blood, urine, stool and tumor samples from patients with advanced or metastatic estrogen receptor positive and HER2 negative breast cancer receiving palbociclib and endocrine therapy (PROMISE) Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Ot3-02-08  0.245
2017 Cairns J, Ingle J, Dudenkov T, Kalari K, Buzdar A, Kubo M, Robson M, Ellis M, Goss P, Shepherd L, Goetz M, Weinshilboum R, Wang L. Abstract PD1-04: CSMD1 SNPs selectively affect anastrozole response in postmenopausal breast cancer patients Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-Pd1-04  0.244
2014 Alvarellos ML, Lamba J, Sangkuhl K, Thorn CF, Wang L, Klein DJ, Altman RB, Klein TE. PharmGKB summary: gemcitabine pathway. Pharmacogenetics and Genomics. 24: 564-74. PMID 25162786 DOI: 10.1097/Fpc.0000000000000086  0.241
2018 Ahmed AT, Biernacka JM, Jenkins GD, Veldic M, Kung S, Bobo WV, Moore K, Flavin DH, Weinshilboum R, Wang L, Mrazek D, Frye M. F177. Pharmacogenomics of Serotonin Noradrenergic Reuptake Inhibitors (SNRIs) Antidepressant Response After Selective Serotonin Reuptake Inhibitors (SSRIs) Treatment Failure in Major Depressive Disorder Biological Psychiatry. 83: S307. DOI: 10.1016/J.Biopsych.2018.02.791  0.241
2017 Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, ... ... Wang L, et al. "The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems". Clinical Pharmacology and Therapeutics. PMID 28090649 DOI: 10.1002/Cpt.630  0.24
2024 Tang X, Prodduturi N, Thompson KJ, Weinshilboum RM, O'Sullivan CC, Boughey JC, Tizhoosh H, Klee EW, Wang L, Goetz MP, Suman V, Kalari KR. OmicsFootPrint: a framework to integrate and interpret multi-omics data using circular images and deep neural networks. Biorxiv : the Preprint Server For Biology. PMID 38585820 DOI: 10.1101/2024.03.21.586001  0.24
2012 Luo K, Zhang H, Wang L, Yuan J, Lou Z. Sumoylation of MDC1 is important for proper DNA damage response. The Embo Journal. 31: 3008-19. PMID 22635276 DOI: 10.1038/Emboj.2012.158  0.239
2019 Liu D, Nguyen TT, Gao H, Ye Z, Lee J, Yan H, Ordog T, Ho M, Wen Z, Coombes B, Wang L, Biernacka J, Frye M, Weinshilboum R. T130. Transcriptome Profile in iPSC-Derived Astrocytes of TCF7L2, a Transcription Factor Associated With Bipolar Disorder, Reveals Relationship With Neural Function Biological Psychiatry. 85: S179. DOI: 10.1016/J.Biopsych.2019.03.453  0.239
2020 Ahmed AT, MahmoudianDehkordi S, Bhattacharyya S, Arnold M, Liu D, Neavin D, Moseley MA, Thompson JW, Williams LSJ, Louie G, Skime MK, Wang L, Riva-Posse P, McDonald WM, Bobo WV, et al. Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes. Journal of Affective Disorders. 264: 90-97. PMID 32056779 DOI: 10.1016/J.Jad.2019.11.122  0.239
2019 Thompson K, Alaparthi T, Sinnwell J, Carlson E, Tang X, Bockol M, Vedell P, Ingle J, Suman V, Weinshilboum R, Wang L, Boughey J, Kalari K, Goetz M. Abstract P1-03-04: Molecular subtyping of androgen receptor-positive patients using gene expression profiles Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P1-03-04  0.239
2021 Liu D, Nguyen TTL, Gao H, Huang H, Kim DC, Sharp B, Ye Z, Lee JH, Coombes BJ, Ordog T, Wang L, Biernacka JM, Frye MA, Weinshilboum RM. TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling. Molecular Psychiatry. PMID 34535768 DOI: 10.1038/s41380-021-01274-z  0.237
2022 Behrens MD, Stiles RJ, Pike GM, Sikkink LA, Zhuang Y, Yu J, Wang L, Boughey JC, Goetz MP, Federspiel MJ. Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer. Molecular Therapy Oncolytics. 27: 239-255. PMID 36458203 DOI: 10.1016/j.omto.2022.11.002  0.237
2020 Qin B, Yu J, Nowsheen S, Zhao F, Wang L, Lou Z. STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation. Science Advances. 6: eaax8214. PMID 32537488 DOI: 10.1126/Sciadv.Aax8214  0.236
2004 Weinshilboum R, Wang L. Pharmacogenetics: Inherited variation in amino acid sequence and altered protein quantity Clinical Pharmacology and Therapeutics. 75: 253-258. PMID 15080131 DOI: 10.1016/J.Clpt.2003.12.002  0.236
2024 Zhou Q, Tu X, Hou X, Yu J, Zhao F, Huang J, Kloeber J, Olson A, Gao M, Luo K, Zhu S, Wu Z, Zhang Y, Sun C, Zeng X, ... ... Wang L, et al. Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 74: 101085. PMID 38636338 DOI: 10.1016/j.drup.2024.101085  0.236
2019 Athreya AP, Iyer R, Wang L, Weinshilboum RM, Bobo WV. Integration of machine learning and pharmacogenomic biomarkers for predicting response to antidepressant treatment: can computational intelligence be used to augment clinical assessments? Pharmacogenomics. 20: 983-988. PMID 31559920 DOI: 10.2217/Pgs-2019-0119  0.234
2017 Emad A, Cairns J, Kalari KR, Wang L, Sinha S. Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance. Genome Biology. 18: 153. PMID 28800781 DOI: 10.1186/S13059-017-1282-3  0.234
2023 Zhou Q, Tu X, Hou X, Yu J, Zhao F, Huang J, Kloeber J, Olson A, Gao M, Luo K, Zhu S, Wu Z, Zhang Y, Sun C, Zeng X, ... ... Wang L, et al. Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy. Research Square. PMID 37333340 DOI: 10.21203/rs.3.rs-2922520/v1  0.233
2021 Yuan Y, Gao H, Zhuang Y, Wei L, Yu J, Zhang Z, Zhang L, Wang L. NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer. Therapeutic Advances in Medical Oncology. 13: 17588359211027836. PMID 34276814 DOI: 10.1177/17588359211027836  0.233
2012 Ji Y, Biernacka J, Snyder K, Drews M, Pelleymounter LL, Colby C, Wang L, Mrazek DA, Weinshilboum RM. Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. The Pharmacogenomics Journal. 12: 78-85. PMID 20877297 DOI: 10.1038/Tpj.2010.69  0.233
2021 Joyce JB, Grant CW, Liu D, MahmoudianDehkordi S, Kaddurah-Daouk R, Skime M, Biernacka J, Frye MA, Mayes T, Carmody T, Croarkin PE, Wang L, Weinshilboum R, Bobo WV, Trivedi MH, et al. Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication. Translational Psychiatry. 11: 513. PMID 34620827 DOI: 10.1038/s41398-021-01632-z  0.232
2018 Ahmed AT, Frye MA, Rush AJ, Biernacka JM, Craighead WE, McDonald WM, Bobo WV, Riva-Posse P, Tye SJ, Mayberg HS, Flavin DH, Skime MK, Jenkins GD, Wang L, Krishnan RR, et al. Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders. 238: 1-7. PMID 29807322 DOI: 10.1016/J.Jad.2018.05.005  0.232
2014 Xu Q, Yang C, Du Y, Chen Y, Liu H, Deng M, Zhang H, Zhang L, Liu T, Liu Q, Wang L, Lou Z, Pei H. AMPK regulates histone H2B O-GlcNAcylation. Nucleic Acids Research. 42: 5594-604. PMID 24692660 DOI: 10.1093/Nar/Gku236  0.231
2015 Breitenstein MK, Wang L, Simon G, Ryu E, Armasu SM, Ray B, Weinshilboum RM, Pathak J. Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis. Amia Joint Summits On Translational Science Proceedings Amia Summit On Translational Science. 2015: 26-30. PMID 26306225  0.231
2018 Liu D, Ray B, Neavin DR, Zhang J, Athreya AP, Biernacka JM, Bobo WV, Hall-Flavin DK, Skime MK, Zhu H, Jenkins GD, Batzler A, Kalari KR, Boakye-Agyeman F, Matson WR, ... ... Wang L, et al. Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics. Translational Psychiatry. 8: 10. PMID 29317604 DOI: 10.1038/S41398-017-0056-8  0.23
2019 Ahmed AT, Dehkordi SM, Bhattacharyya S, Arnold M, Louie G, Dunlop B, Wang L, Weinshilboum R, Krishnan R, Bobo WV, Posse PR, Craighead WE, McDonald W, Skime MK, Rush AJ, et al. T126. Short- Vs Medium + Long-Chain Plasma Acylcarnitine in Phenotypes of Major Depression at Baseline and After Citalopram/Escitalopram Treatment Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.449  0.229
2012 Chalise P, Batzler A, Abo R, Wang L, Fridley BL. Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis. Omics : a Journal of Integrative Biology. 16: 363-73. PMID 22734853 DOI: 10.1089/Omi.2011.0126  0.228
2021 Yu J, Qin B, Moyer AM, Sinnwell JP, Thompson KJ, Copland JA, Marlow LA, Miller JL, Yin P, Gao B, Minter-Dykhouse K, Tang X, McLaughlin SA, Moreno-Aspitia A, Schweitzer A, ... ... Wang L, et al. Correction to: Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study. Breast Cancer Research : Bcr. 23: 41. PMID 33766079 DOI: 10.1186/s13058-021-01420-z  0.228
2018 Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, ... ... Wang L, et al. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Frontiers in Psychiatry. 9: 65. PMID 29559929 DOI: 10.3389/fpsyt.2018.00065  0.226
2017 Mutter R, Tu X, Kahila M, Yu X, Schroeder M, Carlson B, Wang L, Boughey J, Goetz M, Sarkaria J, Lou Z. The Selective ATR Inhibitor VX-970 Enhances the Therapeutic Effects of Radiation Therapy in Triple Negative Breast Cancer Patient-Derived Xenografts and is a Novel Strategy to Overcome Therapeutic Resistance International Journal of Radiation Oncology*Biology*Physics. 99: E611. DOI: 10.1016/J.IJROBP.2017.06.2072  0.225
2023 Blatti C, de la Fuente Cedeño J, Gao H, Marín-Goñi I, Chen Z, Zhao SD, Tan W, Weinshilboum R, Kalari KR, Wang L, Hernaez M. Bayesian machine learning enables identification of transcriptional network disruptions associated with drug-resistant prostate cancer. Cancer Research. PMID 36779846 DOI: 10.1158/0008-5472.CAN-22-1910  0.225
2020 Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim DC, Liu E, Nguyen TTL, Biernacka JM, Kaddurah-Daouk R, Dunlop BW, ... ... Wang L, et al. ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry. PMID 33230203 DOI: 10.1038/s41380-020-00940-y  0.224
2024 Alkhatib H, Conage-Pough J, Roy Chowdhury S, Shian D, Zaid D, Rubinstein AM, Sonnenblick A, Peretz-Yablonsky T, Granit A, Carmon E, Kohale IN, Boughey JC, Goetz MP, Wang L, White FM, et al. Patient-specific signaling signatures predict optimal therapeutic combinations for triple negative breast cancer. Molecular Cancer. 23: 17. PMID 38229082 DOI: 10.1186/s12943-023-01921-9  0.224
2024 Braune EB, Geist F, Tang X, Kalari K, Boughey J, Wang L, Leon-Ferre RA, D'Assoro AB, Ingle JN, Goetz MP, Kreis J, Wang K, Foukakis T, Seshire A, Wienke D, et al. Identification of a Notch transcriptomic signature for breast cancer. Breast Cancer Research : Bcr. 26: 4. PMID 38172915 DOI: 10.1186/s13058-023-01757-7  0.224
2019 Kalari K, Sinnwell J, Thompson K, Tang X, Carlson E, Alaparthi T, Yu J, Vedell P, Kalmbach M, Bockol M, Hossain A, Weinshilboum R, Boughey J, Wang L, Suman V, et al. Abstract P3-06-10: Multiscale modeling of omics data for precision breast cancer treatment Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-P3-06-10  0.224
2014 Matimba A, Li F, Livshits A, Cartwright CS, Scully S, Fridley BL, Jenkins G, Batzler A, Wang L, Weinshilboum R, Lennard L. Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes. Pharmacogenomics. 15: 433-47. PMID 24624911 DOI: 10.2217/Pgs.13.226  0.22
2021 Zhang L, Sarangi V, Ho MF, Moon I, Kalari KR, Wang L, Weinshilboum RM. : Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33658230 DOI: 10.1124/dmd.120.000264  0.217
2008 Yu Z, Wang L, Hildebrandt MA, Schaid DJ. Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis. Statistics in Medicine. 27: 3847-67. PMID 18444230 DOI: 10.1002/Sim.3274  0.215
2022 Chen Y, Peng C, Tan W, Yu J, Zayas J, Peng Y, Lou Z, Pei H, Wang L. Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK. Cancer Medicine. PMID 35666017 DOI: 10.1002/cam4.4911  0.212
2020 Zhou RR, Wang L, Zhao SD. Estimation and inference for the indirect effect in high-dimensional linear mediation models. Biometrika. 107: 573-589. PMID 32831353 DOI: 10.1093/Biomet/Asaa016  0.211
2022 Zhang L, Sarangi V, Liu D, Ho MF, Grassi AR, Wei L, Moon I, Vierkant RA, Larson NB, Lazaridis KN, Athreya AP, Wang L, Weinshilboum R. ACE2 and TMPRSS2 SARS-CoV-2 infectivity genes: deep mutational scanning and characterization of missense variants. Human Molecular Genetics. PMID 35861636 DOI: 10.1093/hmg/ddac157  0.211
2015 Breitenstein MK, Simon G, Ryu E, Armasu SM, Weinshilboum RM, Wang L, Pathak J. Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. Studies in Health Technology and Informatics. 210: 914-8. PMID 25991289  0.21
2016 Fasching P, Loibl S, Eidtmann H, Tesch H, Untch M, Hilfrich J, Schem C, Rezai M, Gerber B, Costa S, Blohmer J, Fehm T, Huober J, Liedtke C, Müller V, ... ... Wang L, et al. Abstract S5-06: BRCA mutations, therapy response and prognosis in the neoadjuvant GeparQuinto study Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-S5-06  0.21
2021 He Y, Wei T, Ye Z, Orme JJ, Lin D, Sheng H, Fazli L, Jeffrey Karnes R, Jimenez R, Wang L, Wang L, Gleave ME, Wang Y, Shi L, Huang H. A noncanonical AR addiction drives enzalutamide resistance in prostate cancer. Nature Communications. 12: 1521. PMID 33750801 DOI: 10.1038/s41467-021-21860-7  0.209
2020 Abeykoon J, Wu X, Nowakowski KE, Dasari S, Paludo J, Weroha SJ, Hu C, Hou X, Sarkaria JN, Mladek AC, Phillips JL, Feldman A, Ravindran A, King RL, Boysen JC, ... ... Wang L, et al. CRM1 inhibitor anti-tumor activity is enhanced with salicylates by S-phase arrest and impaired DNA-damage repair. Blood. PMID 33140103 DOI: 10.1182/blood.2020009013  0.203
2010 Wang L. Pharmacogenomics: a systems approach. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 3-22. PMID 20836007 DOI: 10.1002/wsbm.42  0.203
2022 Lopes JL, Harris K, Karow MB, Peterson SE, Kluge ML, Kotzer KE, Lopes GS, Larson NB, Bielinski SJ, Scherer SE, Wang L, Weinshilboum RM, Black JL, Moyer AM. Targeted Genotyping in Clinical Pharmacogenomics: What is Missing? The Journal of Molecular Diagnostics : Jmd. PMID 35041929 DOI: 10.1016/j.jmoldx.2021.11.008  0.199
2019 Wang S, Huang E, Cairns J, Peng J, Wang L, Sinha S. Identification of pathways associated with chemosensitivity through network embedding. Plos Computational Biology. 15: e1006864. PMID 30893303 DOI: 10.1371/Journal.Pcbi.1006864  0.199
2019 Zhu Y, Swanson KM, Rojas RL, Wang Z, St Sauver JL, Visscher SL, Prokop LJ, Bielinski SJ, Wang L, Weinshilboum R, Borah BJ. Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31591509 DOI: 10.1038/S41436-019-0667-Y  0.198
2020 Yu J, Qin B, Moyer AM, Nowsheen S, Tu X, Dong H, Boughey JC, Goetz MP, Weinshilboum R, Lou Z, Wang L. Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1. Cell Research. PMID 32636455 DOI: 10.1038/S41422-020-0365-Y  0.197
2023 Sperger JM, Helzer KT, Stahlfeld CN, Jiang D, Singh A, Kaufmann KR, Niles DJ, Heninger E, Rydzewski NR, Wang L, Wang L, Yang R, Ren Y, Engle JW, Huang P, et al. Expression and therapeutic targeting of Trop-2 in treatment resistant prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36939530 DOI: 10.1158/1078-0432.CCR-22-1305  0.196
2021 Gao H, Tripathi U, Trushin S, Okromelidze L, Pichurin NP, Wei L, Zhuang Y, Wang L, Trushina E. A Genome-Wide Association Study in Human Lymphoblastoid Cells Supports Safety of Mitochondrial Complex I Inhibitor. Mitochondrion. PMID 33610756 DOI: 10.1016/j.mito.2021.02.005  0.196
2020 Cairns J, Ly RC, Niu N, Kalari KR, Carlson EE, Wang L. CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer. Nar Cancer. 2: zcaa039. PMID 33385163 DOI: 10.1093/narcan/zcaa039  0.195
2018 Leontovich AA, Jalalirad M, Salisbury JL, Mills L, Haddox C, Schroeder M, Tuma A, Guicciardi ME, Zammataro L, Gambino MW, Amato A, Di Leonardo A, McCubrey J, Lange CA, Liu M, ... ... Wang L, et al. NOTCH3 expression is linked to breast cancer seeding and distant metastasis. Breast Cancer Research : Bcr. 20: 105. PMID 30180881 DOI: 10.1186/S13058-018-1020-0  0.194
2015 Breitenstein MK, Simon G, Ryu E, Armasu SM, Weinshilboum RM, Wang L, Pathak J. Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics Studies in Health Technology and Informatics. 210: 914-918. DOI: 10.3233/978-1-61499-512-8-914  0.193
2017 Weinshilboum RM, Wang L. Pharmacogenomics: Precision Medicine and Drug Response. Mayo Clinic Proceedings. 92: 1711-1722. PMID 29101939 DOI: 10.1016/j.mayocp.2017.09.001  0.192
2021 Abeykoon JP, Wu X, Nowakowski KE, Dasari S, Paludo J, Weroha SJ, Hu C, Hou X, Sarkaria JN, Mladek AC, Phillips JL, Feldman AL, Ravindran A, King RL, Boysen J, ... ... Wang L, et al. Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. Blood. 137: 513-523. PMID 33507295 DOI: 10.1182/blood.2020009013  0.19
2023 Lewis AR, Costello BA, Quevedo F, Pagliaro LC, Sanhueza C, Weinshilboum RM, Kalari KR, Wang L, Kohli M, Tan W, Giridhar KV. Dynamic assessment of serum chromogranin A and treatment response with abiraterone acetate in metastatic castration-resistant prostate cancer. The Prostate. PMID 36924119 DOI: 10.1002/pros.24498  0.189
2018 Cairns J, Fridley BL, Jenkins GD, Zhuang Y, Yu J, Wang L. Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation. Embo Reports. PMID 29335246 DOI: 10.15252/Embr.201744767  0.188
1999 Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. The Journal of Physiology. 347-60. PMID 10457054 DOI: 10.1111/J.1469-7793.1999.0347M.X  0.188
2009 Niu N, Manickam V, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Schaid DJ, Wang L. Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics. The Journal of Clinical Endocrinology and Metabolism. 94: 3072-84. PMID 19435830 DOI: 10.1210/jc.2008-2109  0.185
2005 Weinshilboum R, Wang L. Pharmacogenomics: Bench to bedside. Discovery Medicine. 5: 30-6. PMID 20704920  0.185
2019 Zhang L, Sarangi V, Moon I, Devarajan S, Reid JM, Wang L, Weinshilboum R. CYP2C9 and CYP2C19 : Massively Parallel Characterization of the Function of Genomic Missense Variants The Faseb Journal. 33. DOI: 10.1096/fasebj.2019.33.1_supplement.lb66  0.181
2004 Wang L, Yee VC, Weinshilboum RM. Aggresome formation and pharmacogenetics: Sulfotransferase 1A3 as a model system Biochemical and Biophysical Research Communications. 325: 426-433. PMID 15530410 DOI: 10.1016/J.Bbrc.2004.10.040  0.177
2022 Huang J, Du M, Soupir A, Wang L, Tan W, Kalari KR, Kilari D, Park J, Huang CC, Kohli M, Wang L. Plasma Copy Number Alteration-Based Prognostic and Predictive Multi-Gene Risk Score in Metastatic Castration-Resistant Prostate Cancer. Cancers. 14. PMID 36230636 DOI: 10.3390/cancers14194714  0.177
2019 Wang L, Weinshilboum R. Pharmacogenomics in Practice. Clinical Pharmacology and Therapeutics. PMID 31498426 DOI: 10.1002/Cpt.1600  0.175
2020 Song WP, Zheng S, Yao HJ, Zhou XF, Li R, Zhang CY, Zhao JY, Wang LW, Shao RG, Li L. Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism. Bmc Ophthalmology. 20: 92. PMID 32143590 DOI: 10.1186/s12886-020-01348-6  0.175
2018 Vu TN, Wills QF, Kalari KR, Niu N, Wang L, Pawitan Y, Rantalainen M. Isoform-level gene expression patterns in single-cell RNA-sequencing data. Bioinformatics (Oxford, England). PMID 29490015 DOI: 10.1093/Bioinformatics/Bty100  0.174
2017 Yu J, Qin B, Wu F, Qin S, Nowsheen S, Shan S, Zayas J, Pei H, Lou Z, Wang L. Regulation of Serine-Threonine Kinase Akt Activation by NAD(+)-Dependent Deacetylase SIRT7. Cell Reports. 18: 1229-1240. PMID 28147277 DOI: 10.1016/j.celrep.2017.01.009  0.172
2024 Haddad TC, Suman VJ, Giridhar KV, Sideras K, Northfelt DW, Ernst BJ, O'Sullivan CC, Singh RJ, Desta Z, Peethambaram PP, Hobday TJ, Chumsri S, Leon-Ferre RA, Ruddy KJ, Yadav S, ... ... Wang L, et al. Anastrozole dose escalation for optimal estrogen suppression in postmenopausal early-stage breast cancer: A prospective trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38752717 DOI: 10.1158/1078-0432.CCR-24-0341  0.172
2018 Kurmi K, Hitosugi S, Yu J, Boakye-Agyeman F, Wiese EK, Larson TR, Dai Q, Machida YJ, Lou Z, Wang L, Boughey JC, Kaufmann SH, Goetz MP, Karnitz LM, Hitosugi T. Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway. Cell Metabolism. PMID 30174304 DOI: 10.1016/J.Cmet.2018.08.008  0.171
2013 Heyn H, Moran S, Hernando-Herraez I, Sayols S, Gomez A, Sandoval J, Monk D, Hata K, Marques-Bonet T, Wang L, Esteller M. DNA methylation contributes to natural human variation. Genome Research. 23: 1363-72. PMID 23908385 DOI: 10.1101/Gr.154187.112  0.17
2021 Kohale IN, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey JC, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM. Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient-specific signaling networks. Cancer Research. PMID 34016623 DOI: 10.1158/0008-5472.CAN-21-0214  0.17
2018 Neavin D, Liu D, Li H, Wang L, Weinshilboum R. SNPs Outside Response Elements Impact Aryl Hydrocarbon Receptor (AHR) Binding and Gene Regulation: Genome‐wide SNP‐dependent Transcriptional Regulation The Faseb Journal. 32. DOI: 10.1096/FASEBJ.2018.32.1_SUPPLEMENT.694.3  0.168
2019 Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, ... ... Wang L, et al. The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 30610379 DOI: 10.1007/s00702-018-01966-x  0.166
2019 Hunt KN, Conners AL, Goetz MP, O'Connor MK, Suman V, Kalari K, Weinshilboum R, Wang L, Carter J, McLaughlin S, Aspitia AM, Gray R, Northfelt D, Boughey JC. Comparison of Tc-Sestamibi Molecular Breast Imaging and Breast MRI in Patients With Invasive Breast Cancer Receiving Neoadjuvant Chemotherapy. Ajr. American Journal of Roentgenology. 1-12. PMID 31166752 DOI: 10.2214/AJR.18.20628  0.165
2022 Grant CW, Barreto EF, Kumar R, Kaddurah-Daouk R, Skime M, Mayes T, Carmody T, Biernacka J, Wang L, Weinshilboum R, Trivedi MH, Bobo WV, Croarkin PE, Athreya AP. Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder. Journal of Personalized Medicine. 12. PMID 35330412 DOI: 10.3390/jpm12030412  0.163
2023 Das T, Bhattarai K, Rajaganapathy S, Wang L, Cerhan JR, Zong N. Leveraging multi-source to resolve inconsistency across pharmacogenomic datasets in drug sensitivity prediction. Medrxiv : the Preprint Server For Health Sciences. PMID 37333219 DOI: 10.1101/2023.05.25.23290546  0.161
2022 Wang L, Scherer SE, Bielinski SJ, Muzny DM, Jones LA, Black JL, Moyer AM, Giri J, Sharp RR, Matey ET, Wright JA, Oyen LJ, Nicholson WT, Wiepert M, Sullard T, ... ... Wang L, et al. Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35331649 DOI: 10.1016/j.gim.2022.01.022  0.161
2003 Wang L, Sullivan W, Toft D, Weinshilboum R. Thiopurine S-methyltransferase pharmacogenetics: Chaperone protein association and allozyme degradation Pharmacogenetics. 13: 555-564. PMID 12972954 DOI: 10.1097/00008571-200309000-00004  0.161
2018 Fasching PA, Loibl S, Hu C, Hart SN, Shimelis H, Moore R, Schem C, Tesch H, Untch M, Hilfrich J, Rezai M, Gerber B, Costa SD, Blohmer JU, Fehm T, ... ... Wang L, et al. BRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017772285. PMID 29791287 DOI: 10.1200/Jco.2017.77.2285  0.154
2022 Zhu X, Gao H, Qin S, Liu D, Cairns J, Gu Y, Yu J, Weinshilboum RM, Wang L. Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of expression through Wnt signaling. Frontiers in Pharmacology. 13: 1047318. PMID 36518674 DOI: 10.3389/fphar.2022.1047318  0.152
2016 Vu TN, Wills QF, Kalari KR, Niu N, Wang L, Rantalainen M, Pawitan Y. Beta-Poisson model for single-cell RNA-seq data analyses. Bioinformatics (Oxford, England). PMID 27153638 DOI: 10.1093/Bioinformatics/Btw202  0.151
2015 Ingle JN, Kalari KR, Buzdar AU, Robson ME, Goetz MP, Desta Z, Barman P, Dudenkov TT, Northfelt DW, Perez EA, Flockhart DA, Williard CV, Wang L, Weinshilboum RM. Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole. Steroids. 99: 32-8. PMID 25163006 DOI: 10.1016/j.steroids.2014.08.007  0.15
2014 Bielinski SJ, Olson JE, Pathak J, Weinshilboum RM, Wang L, Lyke KJ, Ryu E, Targonski PV, Van Norstrand MD, Hathcock MA, Takahashi PY, McCormick JB, Johnson KJ, Maschke KJ, Rohrer Vitek CR, et al. Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol. Mayo Clinic Proceedings. 89: 25-33. PMID 24388019 DOI: 10.1016/j.mayocp.2013.10.021  0.143
2021 Athreya AP, Brückl T, Binder EB, John Rush A, Biernacka J, Frye MA, Neavin D, Skime M, Monrad D, Iyer RK, Mayes T, Trivedi M, Carter RE, Wang L, Weinshilboum RM, et al. Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33452433 DOI: 10.1038/s41386-020-00943-x  0.142
2016 Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, Deng M, Qin B, Correia C, Lee S, Kim J, Sparks M, Nair AA, Evans DL, Kalari KR, ... ... Wang L, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nature Communications. 7: 10201. PMID 26727879 DOI: 10.1038/Ncomms10201  0.137
2021 Zhou Q, Howard ME, Tu X, Zhu Q, Denbeigh JM, Remmes NB, Herman MG, Beltran CJ, Yuan J, Greipp PT, Boughey JC, Wang L, Johnson N, Goetz MP, Sarkaria JN, et al. Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining. Cancer Research. PMID 33597272 DOI: 10.1158/0008-5472.CAN-20-2960  0.134
2019 Liu D, Zhuang Y, Neavin D, Zhang L, Kaddurah‐Daouk R, Wang L, Weinshilboum R. ERICH3 Characterization: Function in Vesicular Trafficking and Antidepressant Treatment Response The Faseb Journal. 33. DOI: 10.1096/fasebj.2019.33.1_supplement.680.1  0.128
2019 Wu X, Li Y, Liu X, Chen C, Harrington SM, Cao S, Xie T, Pham T, Mansfield AS, Yan Y, Kwon ED, Wang L, Ling K, Dong H. Corrigendum to "Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy" [Heliyon 4 (12) (December 2018) e01039]. Heliyon. 5: e01309. PMID 30937406 DOI: 10.1016/j.heliyon.2019.e01309  0.121
2024 Ruiz-Arenas C, Marín-Goñi I, Wang L, Ochoa I, Pérez-Jurado LA, Hernaez M. NetActivity enhances transcriptional signals by combining gene expression into robust gene set activity scores through interpretable autoencoders. Nucleic Acids Research. PMID 38597610 DOI: 10.1093/nar/gkae197  0.12
2018 Orlenko A, Moore JH, Orzechowski P, Olson RS, Cairns J, Caraballo PJ, Weinshilboum RM, Wang L, Breitenstein MK. Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 23: 460-471. PMID 29218905  0.12
2021 Zhu Y, Lopes GS, Bielinski SJ, Borah BJ, Larson NB, Moyer AM, Olson JE, Wang L, Weinshilboum R, St Sauver JL. Impact of Pharmacogenomic Information on Values of Care and Quality of Life Associated with Codeine and Tramadol-Related Adverse Drug Events. Mayo Clinic Proceedings. Innovations, Quality & Outcomes. 5: 35-45. PMID 33718782 DOI: 10.1016/j.mayocpiqo.2020.08.009  0.117
2021 Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience. PMID 34916658 DOI: 10.1038/s41593-021-00975-6  0.113
2003 Prondzinski J, Thomae B, Wang L, Eckloff B, Wieben E, Weinshilboum R. Sulfotransferase (sult) 1A1 pharmacogenetics: Functional 5′‐flanking region (5′‐FR) polymorphisms Clinical Pharmacology & Therapeutics. 73. DOI: 10.1016/S0009-9236(03)90641-2B  0.112
2019 Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, Li H, Wang L, Lou Z. UFL1 promotes histone H4 ufmylation and ATM activation. Nature Communications. 10: 1242. PMID 30886146 DOI: 10.1038/s41467-019-09175-0  0.111
2022 Grant CW, Wilton AR, Kaddurah-Daouk R, Skime M, Biernacka J, Mayes T, Carmody T, Wang L, Lazaridis K, Weinshilboum R, Bobo WV, Trivedi MH, Croarkin PE, Athreya AP. Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder. Frontiers in Pharmacology. 13: 984383. PMID 36263124 DOI: 10.3389/fphar.2022.984383  0.109
2005 WANG L, WEINSHILBOUM R. Human thiopurine S-methyltransferase (TPMT) pharmacogenetics: Variant allozyme aggresome formation Clinical Pharmacology & Therapeutics. 77: P95-P95. DOI: 10.1016/J.Clpt.2004.12.257  0.107
2020 Zhu Y, Moriarty JP, Swanson KM, Takahashi PY, Bielinski SJ, Weinshilboum R, Wang L, Borah BJ. A model-based cost-effectiveness analysis of pharmacogenomic panel testing in cardiovascular disease management: preemptive, reactive, or none? Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 33041335 DOI: 10.1038/s41436-020-00995-w  0.106
2017 Schiffer J, Srinivasan S, Lopez A, Wang L, Proll S, Yuhas K, Hughes J, Wald A, Fredricks D. O11.3 Extreme heterogeneity in vaginal microbial kinetics within and across women Sexually Transmitted Infections. 93. DOI: 10.1136/Sextrans-2017-053264.63  0.106
2003 Wang L, Sullivan W, Toft D, Weinshilboum R. Thiopurine S-Methyltransferase (TPMT) Pharmacogenetics: Role of Chaperone Proteins in variant Allozyme Degradation Clinical Pharmacology & Therapeutics. 73: P29-P29. DOI: 10.1016/S0009-9236(03)90460-7  0.105
2021 Myasoedova E, Athreya AP, Crowson CS, Davis JM, Warrington KJ, Walchak RC, Carlson E, Kalari KR, Bongartz T, Tak PP, van Vollenhoven RF, Padyukov L, Emery P, Morgan A, Wang L, et al. Towards Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis: a Pharmacogenomics-driven Machine Learning Approach. Arthritis Care & Research. PMID 34902228 DOI: 10.1002/acr.24834  0.103
2023 Sanchez-Ruiz JA, Leibman NI, Larson NB, Jenkins GD, Ahmed AT, Nunez NA, Biernacka JM, Winham SJ, Weinshilboum RM, Wang L, Frye MA, Ozerdem A. Age-Dependent Sex Differences in the Prevalence of Selective Serotonin Reuptake Inhibitor Treatment: A Retrospective Cohort Analysis. Journal of Women's Health (2002). PMID 37856151 DOI: 10.1089/jwh.2022.0484  0.103
2023 Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, ... ... Wang L, et al. SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. Molecular Cell. PMID 36854302 DOI: 10.1016/j.molcel.2023.02.004  0.101
2011 Wang L. FKBP51 regulation of AKT/protein kinase B phosphorylation. Current Opinion in Pharmacology. 11: 360-4. PMID 21498116 DOI: 10.1016/j.coph.2011.03.008  0.095
2022 Duong SQ, Crowson CS, Athreya A, Atkinson EJ, Davis JM, Warrington KJ, Matteson EL, Weinshilboum R, Wang L, Myasoedova E. Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data. Arthritis Research & Therapy. 24: 162. PMID 35778714 DOI: 10.1186/s13075-022-02851-5  0.091
2023 Zong N, Chowdhury S, Zhou S, Rajaganapathy S, Yu Y, Wang L, Dai Q, Bielinski SJ, Chen Y, Cerhan JR. Artificial Intelligence-based Efficacy Prediction of Phase 3 Clinical Trial for Repurposing Heart Failure Therapies. Medrxiv : the Preprint Server For Health Sciences. PMID 37398384 DOI: 10.1101/2023.05.25.23290531  0.086
2020 Qi L, Zhang Y, Wang L, Wang R, Wu J, Zhou X, Chen J, Zhang S, Zhou Y, Zhang XY. Sex differences in psychotic and non-psychotic major depressive disorder in a Chinese Han population. Journal of Affective Disorders. 268: 55-60. PMID 32158007 DOI: 10.1016/j.jad.2020.03.003  0.071
2016 Deng M, Yang X, Qin B, Liu T, Zhang H, Guo W, Lee SB, Kim JJ, Yuan J, Pei H, Wang L, Lou Z. Deubiquitination and Activation of AMPK by USP10. Molecular Cell. PMID 26876938 DOI: 10.1016/J.Molcel.2016.01.010  0.067
2022 Athreya AP, Vande Voort JL, Shekunov J, Rackley SJ, Leffler JM, McKean AJ, Romanowicz M, Kennard BD, Emslie GJ, Mayes T, Trivedi M, Wang L, Weinshilboum RM, Bobo WV, Croarkin PE. Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants. Journal of Child Psychology and Psychiatry, and Allied Disciplines. PMID 35288932 DOI: 10.1111/jcpp.13580  0.059
2016 Bielinski SJ, St Sauver JL, Olson JE, Wieland ML, Vitek CR, Bell EJ, Mc Gree ME, Jacobson DJ, McCormick JB, Takahashi PY, Black JL, Caraballo PJ, Sharp RR, Beebe TJ, Weinshilboum RM, ... Wang L, et al. Are patients willing to incur out-of-pocket costs for pharmacogenomic testing? The Pharmacogenomics Journal. PMID 27779246 DOI: 10.1038/tpj.2016.72  0.049
2010 Pei H, Lou Z, Wang L. Emerging role of FKBP51 in AKT kinase/protein kinase B signaling. Cell Cycle (Georgetown, Tex.). 9: 6-7. PMID 20016266 DOI: 10.4161/cc.9.1.10290  0.048
2010 Wang L, Pelleymounter L, Weinshilboum R, Johnson JA, Hebert JM, Altman RB, Klein TE. Very important pharmacogene summary: thiopurine S-methyltransferase. Pharmacogenetics and Genomics. 20: 401-5. PMID 20154640 DOI: 10.1097/FPC.0b013e3283352860  0.046
2019 Iyer RK, Athreya AP, Wang L, Weinshilboum RM. Artificial Intelligence and Pharmacogenomics Advances in Molecular Pathology. 2: 111-118. DOI: 10.1016/j.yamp.2019.08.003  0.032
2013 Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Shuldiner AR, Vesely M, Robinson SW, Ambulos N, ... ... Wang L, et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clinical Pharmacology and Therapeutics. 94: 207-10. PMID 23588301 DOI: 10.1038/clpt.2013.59  0.027
2021 Zhou T, Chen W, Liu X, Wu T, Wen L, Yang X, Hou Z, Chen B, Zhang T, Zhang C, Xie C, Zhou X, Wang L, Hua J, Tang Q, et al. Children of parents with mental illness in the COVID-19pandemic: A cross-sectional survey in China. Asian Journal of Psychiatry. 64: 102801. PMID 34388668 DOI: 10.1016/j.ajp.2021.102801  0.018
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