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Charles Shyng, PhD - Publications

Affiliations: 
2010-2016 DBBS Washington University, Saint Louis, St. Louis, MO 
 2016-2018 Gene Therapy Center University of North Carolina, Chapel Hill, Chapel Hill, NC 
 2018-2021 Rare Disease Research Unit Pfizer Worldwide Research, Development and Medical 
 2021- Liver Spark Therapeutics 
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10 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Casy W, Garza IT, Chen X, Dong T, Hu Y, Kanchwala M, Trygg CB, Shyng C, Xing C, Bunnell BA, Braun SE, Gray SJ. SMRT Sequencing Enables High-Throughput Identification of Novel AAVs from Capsid Shuffling and Directed Evolution. Genes. 14. PMID 37628711 DOI: 10.3390/genes14081660  0.355
2021 Judson MC, Shyng C, Simon JM, Davis CR, Punt AM, Salmon MT, Miller NW, Ritola KD, Elgersma Y, Amaral DG, Gray SJ, Philpot BD. Dual-isoform hUBE3A gene transfer improves behavioral and seizure outcomes in Angelman syndrome model mice. Jci Insight. 6. PMID 34676830 DOI: 10.1172/jci.insight.144712  0.664
2018 Lykken EA, Shyng C, Edwards RJ, Rozenberg A, Gray SJ. Recent progress and considerations for AAV gene therapies targeting the central nervous system. Journal of Neurodevelopmental Disorders. 10: 16. PMID 29776328 DOI: 10.1186/S11689-018-9234-0  0.574
2018 Nelvagal HR, Shyng C, Sands MS, Cooper JD. Early gait abnormalities relate to brainstem and spinal cord pathology in CLN1 disease Molecular Genetics and Metabolism. 123: S104. DOI: 10.1016/J.Ymgme.2017.12.275  0.508
2017 Shyng C, Nelvagal HR, Dearborn JT, Tyynelä J, Schmidt RE, Sands MS, Cooper JD. Synergistic effects of treating the spinal cord and brain in CLN1 disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28673981 DOI: 10.1073/Pnas.1701832114  0.578
2017 Shyng C, Macauley SL, Dearborn JT, Sands MS. Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1. Jimd Reports. PMID 28213849 DOI: 10.1007/8904_2017_1  0.489
2016 Shyng C, Nelvagal HR, Dearborn JT, Cooper JD, Sands MS. 27. Therapeutic Efficacy of Intracranial and Intrathecal AAV2/9-PPT1 in Infantile Batten Disease Molecular Therapy. 24: S12-S13. DOI: 10.1016/S1525-0016(16)32836-2  0.581
2015 Dearborn JT, Ramachandran S, Shyng C, Lu JY, Thornton J, Hofmann SL, Sands MS. Histochemical localization of palmitoyl protein thioesterase-1 activity. Molecular Genetics and Metabolism. PMID 26597320 DOI: 10.1016/J.Ymgme.2015.11.004  0.58
2014 Macauley SL, Wong AM, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS. An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13077-82. PMID 25253854 DOI: 10.1523/Jneurosci.2518-14.2014  0.585
2014 Shyng C, Sands MS. Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe? Biochemical Society Transactions. 42: 1282-5. PMID 25233404 DOI: 10.1042/Bst20140188  0.543
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