Michael Freissmuth - Publications

Affiliations: 
Institute of Pharmacology Medical University of Vienna, Austria, Wien, Wien, Austria 

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. PMID 31028773 DOI: 10.1016/j.neuropharm.2019.04.021  0.88
2019 El-Kasaby A, Kasture A, Koban F, Hotka M, Asjad HMM, Kubista H, Freissmuth M, Sucic S. Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome. Neuropharmacology. PMID 30885608 DOI: 10.1016/j.neuropharm.2019.03.015  0.52
2019 Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M. Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction. Neuropharmacology. PMID 30851308 DOI: 10.1016/j.neuropharm.2019.03.007  0.52
2018 Hasenhuetl PS, Bhat S, Freissmuth M, Sandtner W. Functional selectivity and partial efficacy at the monoamine transporters: a unified model of allosteric modulation and amphetamine-induced substrate release. Molecular Pharmacology. PMID 30567955 DOI: 10.1124/mol.118.114793  0.56
2018 Themanns M, Koban F, Bergmayr C, Chrzan A, Strohmaier W, Haybaeck J, Freissmuth M, Zebedin-Brandl E. Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome. Journal of Molecular Medicine (Berlin, Germany). PMID 30535954 DOI: 10.1007/s00109-018-1726-6  0.44
2018 Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz-Trząska D, Sucic S, Freissmuth M, Nałęcz KA. Trafficking of the amino acid transporter B (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum. Biochimica Et Biophysica Acta. Molecular Cell Research. PMID 30445147 DOI: 10.1016/j.bbamcr.2018.11.005  0.52
2018 Kasture AS, Hummel T, Sucic S, Freissmuth M. Big Lessons from Tiny Flies: as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems. International Journal of Molecular Sciences. 19. PMID 29914172 DOI: 10.3390/ijms19061788  0.52
2018 Hamali B, Pichler S, Wischnitzki E, Schicker K, Burger M, Holy M, Jaentsch K, Molin M, Sehr EM, Kudlacek O, Freissmuth M. Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter. Plos Neglected Tropical Diseases. 12: e0006428. PMID 29702654 DOI: 10.1371/journal.pntd.0006428  0.64
2018 Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W. A label-free approach to detect ligand binding to cell surface proteins in real time. Elife. 7. PMID 29697048 DOI: 10.7554/eLife.34944  0.56
2018 Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W. A kinetic account for amphetamine-induced monoamine release. The Journal of General Physiology. PMID 29439119 DOI: 10.1085/jgp.201711915  0.88
2017 Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C. Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters. International Journal of Molecular Sciences. 18. PMID 29135937 DOI: 10.3390/ijms18112416  0.52
2017 Freissmuth M, Stockner T, Sucic S. SLC6 Transporter Folding Diseases and Pharmacochaperoning. Handbook of Experimental Pharmacology. PMID 29086036 DOI: 10.1007/164_2017_71  0.6
2017 Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S. PHARMACOCHAPERONING IN A DROSOPHILA MODEL SYSTEM RESCUES HUMAN DOPAMINE TRANSPORTER VARIANTS ASSOCIATED WITH INFANTILE/JUVENILE PARKINSONISM. The Journal of Biological Chemistry. PMID 28972153 DOI: 10.1074/jbc.M117.797092  0.52
2017 Kasture A, Stockner T, Freissmuth M, Sucic S. An unfolding story: small molecules remedy misfolded monoamine transporters. The International Journal of Biochemistry & Cell Biology. PMID 28890376 DOI: 10.1016/j.biocel.2017.09.004  0.6
2017 Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M. Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates. The Journal of Biological Chemistry. PMID 28842491 DOI: 10.1074/jbc.M117.794081  0.56
2017 Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH. Cocaine adulteration. Journal of Chemical Neuroanatomy. PMID 28619473 DOI: 10.1016/j.jchemneu.2017.06.001  0.88
2017 Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T. Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept. Pharmacology Research & Perspectives. 5: e00325. PMID 28603639 DOI: 10.1002/prp2.325  0.6
2017 Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism. The Journal of Biological Chemistry. 292: 7161. PMID 28455408 DOI: 10.1074/jbc.A116.760140  0.88
2017 Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S. The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter. The Journal of Biological Chemistry. 292: 3603-3613. PMID 28104804 DOI: 10.1074/jbc.M116.771360  0.56
2017 Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Occupancy of the Zinc Binding-site by Transition Metals decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism. The Journal of Biological Chemistry. PMID 28096460 DOI: 10.1074/jbc.M116.760140  0.88
2016 Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M. When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters. Journal of Neurology & Neuromedicine. 1: 34-40. PMID 28405636  0.52
2016 Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH. Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters. Current Topics in Behavioral Neurosciences. PMID 28025810 DOI: 10.1007/7854_2016_63  0.88
2016 Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T. The Environment Shapes the Inner Vestibule of LeuT. Plos Computational Biology. 12: e1005197. PMID 27835643 DOI: 10.1371/journal.pcbi.1005197  0.88
2016 Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G. Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells. Thrombosis and Haemostasis. 117. PMID 27761583 DOI: 10.1160/TH16-01-0045  0.52
2016 Hasenhuetl PS, Freissmuth M, Sandtner W. Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter. The Journal of Biological Chemistry. 291: 25864-25876. PMID 27756841 DOI: 10.1074/jbc.M116.753319  0.56
2016 Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, ... ... Freissmuth M, et al. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell. 30: 359-360. PMID 27505678 DOI: 10.1016/j.ccell.2016.07.003  0.32
2016 Kasture A, El-Kasaby A, Szöllősi D, Asjad HM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S. Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones. The Journal of Biological Chemistry. PMID 27481941 DOI: 10.1074/jbc.M116.737551  0.6
2016 Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C. A COMPARISON OF THE β-ADRENERGIC RECEPTOR ANTAGONISTS LANDIOLOL AND ESMOLOL: RECEPTOR SELECTIVITY, PARTIAL AGONISM AND PHARMACOCHAPERONING ACTIONS. The Journal of Pharmacology and Experimental Therapeutics. PMID 27451411 DOI: 10.1124/jpet.116.232884  0.52
2016 Kazemi Z, Bergmayr C, Prchal-Murphy M, Javaheri T, Themanns M, Pham HT, Strohmaier W, Sexl V, Freissmuth M, Zebedin-Brandl E. Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation. Molecular Pharmacology. 89: 630-44. PMID 26989084 DOI: 10.1124/mol.116.103267  0.32
2015 Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, et al. Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites. Angewandte Chemie (International Ed. in English). PMID 26695726 DOI: 10.1002/anie.201508755  0.48
2015 Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter. The Journal of Biological Chemistry. 290: 31069-76. PMID 26504078 DOI: 10.1074/jbc.M115.688275  0.88
2015 Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T. Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site. Plos Computational Biology. 11: e1004551. PMID 26485255 DOI: 10.1371/journal.pcbi.1004551  0.88
2015 Kong E, Sucic S, Monje FJ, Reisinger SN, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD. Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour. Scientific Reports. 5: 11965. PMID 26177279 DOI: 10.1038/srep11965  0.52
2015 Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8258-71. PMID 26019340 DOI: 10.1523/JNEUROSCI.4034-14.2015  0.88
2015 Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular Pharmacology. 88: 12-8. PMID 25873594 DOI: 10.1124/mol.115.099036  0.88
2015 Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S. A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter. The Journal of Biological Chemistry. 290: 13263-78. PMID 25869136 DOI: 10.1074/jbc.M115.641357  0.88
2015 Sitte HH, Schütz GJ, Freissmuth M. Cooperativity between individual transporter protomers: new data fuelling old complexes. Journal of Neurochemistry. 133: 163-6. PMID 25772534 DOI: 10.1111/jnc.13086  0.88
2015 Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Scientific Reports. 5: 9009. PMID 25760924 DOI: 10.1038/srep09009  0.52
2015 Sitte HH, Freissmuth M. Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends in Pharmacological Sciences. 36: 41-50. PMID 25542076 DOI: 10.1016/j.tips.2014.11.006  0.88
2015 Kusek J, Yang Q, Witek M, Gruber CW, Nanoff C, Freissmuth M. Chaperoning of the a1-adenosine receptor by endogenous adenosine-an extension of the retaliatory metabolite concept Molecular Pharmacology. 87: 39-51. PMID 25354767 DOI: 10.1124/mol.114.094045  0.48
2015 Promberger R, Ott J, Bures C, Freissmuth M, Seemann R, Hermann M. Perioperative kinetics of parathyroid hormone in unilateral, primary thyroid surgery. Endocrine. 48: 293-8. PMID 24858628 DOI: 10.1007/s12020-014-0300-4  0.48
2014 El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S. A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. The Journal of Biological Chemistry. 289: 28987-9000. PMID 25202009 DOI: 10.1074/jbc.M114.595090  0.88
2014 Michl J, Scharinger C, Zauner M, Kasper S, Freissmuth M, Sitte HH, Ecker GF, Pezawas L. A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1463-74. PMID 25044049 DOI: 10.1016/j.euroneuro.2014.06.013  0.48
2014 Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P. Pharmacological correction of misfolding of ABC proteins. Drug Discovery Today. Technologies. 12: e87-94. PMID 25027379 DOI: 10.1016/j.ddtec.2014.03.009  0.6
2014 Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, et al. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2681-93. PMID 24871545 DOI: 10.1038/npp.2014.124  0.48
2014 Anderluh A, Klotzsch E, Ries J, Reismann AW, Weber S, Fölser M, Koban F, Freissmuth M, Sitte HH, Schütz GJ. Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane. Biophysical Journal. 106: L33-5. PMID 24806941 DOI: 10.1016/j.bpj.2014.03.019  0.88
2014 Burtscher V, Schicker K, Novikova E, Pöhn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, Koschak A. Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. Biochimica Et Biophysica Acta. 1838: 2053-65. PMID 24796500 DOI: 10.1016/j.bbamem.2014.04.023  0.6
2014 Montgomery TR, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, Sitte HH, Freissmuth M. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6344-51. PMID 24790205 DOI: 10.1523/JNEUROSCI.2991-13.2014  0.88
2014 Promberger R, Ott J, Bures C, Kober F, Freissmuth M, Seemann R, Hermann M. Can a surgeon predict the risk of postoperative hypoparathyroidism during thyroid surgery? A prospective study on self-assessment by experts. American Journal of Surgery. 208: 13-20. PMID 24746378 DOI: 10.1016/j.amjsurg.2013.11.007  0.48
2014 Scharinger C, Rabl U, Kasess CH, Meyer BM, Hofmaier T, Diers K, Bartova L, Pail G, Huf W, Uzelac Z, Hartinger B, Kalcher K, Perkmann T, Haslacher H, Meyer-Lindenberg A, ... ... Freissmuth M, et al. Platelet serotonin transporter function predicts default-mode network activity. Plos One. 9: e92543. PMID 24667541 DOI: 10.1371/journal.pone.0092543  0.48
2014 Thurner P, Gsandtner I, Kudlacek O, Choquet D, Nanoff C, Freissmuth M, Zezula J. A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102). The Journal of Biological Chemistry. 289: 9263-74. PMID 24509856 DOI: 10.1074/jbc.M113.505685  0.48
2014 Chiba P, Freissmuth M, Stockner T. Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters. Pharmacological Research. 83: 63-73. PMID 24316454 DOI: 10.1016/j.phrs.2013.11.009  0.6
2014 Hofmaier T, Luf A, Seddik A, Stockner T, Holy M, Freissmuth M, Ecker GF, Schmid R, Sitte HH, Kudlacek O. Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. Neurochemistry International. 73: 32-41. PMID 24296074 DOI: 10.1016/j.neuint.2013.11.010  0.88
2014 Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer FP, Boehm S, Freissmuth M, Sitte HH. A quantitative model of amphetamine action on the 5-HT transporter. British Journal of Pharmacology. 171: 1007-18. PMID 24251585 DOI: 10.1111/bph.12520  0.48
2013 Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, ... Freissmuth M, et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America. 110: 21183-8. PMID 24248349 DOI: 10.1073/pnas.1311183110  0.48
2013 Bergmayr C, Thurner P, Keuerleber S, Kudlacek O, Nanoff C, Freissmuth M, Gruber CW. Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor Journal of Biological Chemistry. 288: 28831-28844. PMID 23965991 DOI: 10.1074/jbc.M113.464776  0.48
2013 Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, ... ... Freissmuth M, et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell. 24: 167-81. PMID 23948297 DOI: 10.1016/j.ccr.2013.07.012  0.32
2013 Hussain F, Freissmuth M, Völkel D, Thiele M, Douillard P, Antoine G, Thurner P, Ehrlich H, Schwarz HP, Scheiflinger F, Kerschbaumer RJ. Human anti-macrophage migration inhibitory factor antibodies inhibit growth of human prostate cancer cells in vitro and in vivo. Molecular Cancer Therapeutics. 12: 1223-34. PMID 23619302 DOI: 10.1158/1535-7163.MCT-12-0988  0.48
2013 Prchal-Murphy M, Putz EM, Freissmuth M, Sexl V, Zebedin-Brandl E. Targeting PI3Kδ: One man's meat is another man's poison. Oncoimmunology. 2: e22272. PMID 23482629 DOI: 10.4161/onci.22272  0.32
2013 Stockner T, Montgomery TR, Kudlacek O, Weissensteiner R, Ecker GF, Freissmuth M, Sitte HH. Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model. Plos Computational Biology. 9: e1002909. PMID 23436987 DOI: 10.1371/journal.pcbi.1002909  0.88
2013 Rosenauer R, Luf A, Holy M, Freissmuth M, Schmid R, Sitte HH. A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content. Acs Chemical Neuroscience. 4: 182-90. PMID 23336057 DOI: 10.1021/cn3001763  0.88
2013 Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M. Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. The Journal of Biological Chemistry. 288: 5330-41. PMID 23288844 DOI: 10.1074/jbc.M112.408237  0.88
2012 Keuerleber S, Thurner P, Gruber CW, Zezula J, Freissmuth M. Reengineering the collision coupling and diffusion mode of the A 2A-adenosine receptor: Palmitoylation in helix 8 relieves confinement Journal of Biological Chemistry. 287: 42104-42118. PMID 23071116 DOI: 10.1074/jbc.M112.393579  0.48
2012 Kastner S, Voss T, Keuerleber S, Glöckel C, Freissmuth M, Sommergruber W. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. Molecular Cancer Research : McR. 10: 1343-58. PMID 22912338 DOI: 10.1158/1541-7786.MCR-12-0139  0.48
2012 Putz EM, Prchal-Murphy M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M, Müller M, Sexl V, Zebedin-Brandl E. PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes. Plos One. 7: e40852. PMID 22808277 DOI: 10.1371/journal.pone.0040852  0.48
2012 Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of Biological Chemistry. 287: 29627-35. PMID 22778257 DOI: 10.1074/jbc.M112.367219  0.48
2012 Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of Biological Chemistry. 287: 18524-34. PMID 22451652 DOI: 10.1074/jbc.M112.343681  0.48
2012 Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W. Unifying concept of serotonin transporter-associated currents. The Journal of Biological Chemistry. 287: 438-45. PMID 22072712 DOI: 10.1074/jbc.M111.304261  0.48
2012 Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P. Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. The Journal of Biological Chemistry. 287: 105-13. PMID 22033932 DOI: 10.1074/jbc.M111.304873  0.48
2011 Schuster C, Berger A, Hoelzl MA, Putz EM, Frenzel A, Simma O, Moritz N, Hoelbl A, Kovacic B, Freissmuth M, Müller M, Villunger A, Müllauer L, Schmatz AI, Streubel B, et al. The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas. Blood. 118: 4635-45. PMID 21878673 DOI: 10.1182/blood-2010-10-313098  0.32
2011 Geetha N, Mihaly J, Stockenhuber A, Blasi F, Uhrin P, Binder BR, Freissmuth M, Breuss JM. Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6). The Journal of Biological Chemistry. 286: 25663-74. PMID 21610072 DOI: 10.1074/jbc.M111.221903  0.48
2011 Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of Biological Chemistry. 286: 16482-90. PMID 21454670 DOI: 10.1074/jbc.M111.230037  0.88
2011 Steinkellner T, Freissmuth M, Sitte HH, Montgomery T. The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine. Biological Chemistry. 392: 103-15. PMID 21194370 DOI: 10.1515/BC.2011.016  0.88
2011 Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P. Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein. Molecular Pharmacology. 79: 443-52. PMID 21177413 DOI: 10.1124/mol.110.067611  0.6
2010 El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter. The Journal of Biological Chemistry. 285: 39201-10. PMID 20889976 DOI: 10.1074/jbc.M110.118000  0.88
2010 Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular Pharmacology. 78: 1026-35. PMID 20829432 DOI: 10.1124/mol.110.067538  0.88
2010 Gruber CW, Muttenthaler M, Freissmuth M. Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors Current Pharmaceutical Design. 16: 3071-3088. PMID 20687879 DOI: 10.2174/138161210793292474  0.48
2010 Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of Biological Chemistry. 285: 10924-38. PMID 20118234 DOI: 10.1074/jbc.M109.083154  0.48
2010 Sitte HH, Freissmuth M. The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango. Journal of Neurochemistry. 112: 340-55. PMID 19891736 DOI: 10.1111/j.1471-4159.2009.06474.x  0.88
2009 Milan-Lobo L, Gsandtner I, Gaubitzer E, Rünzler D, Buchmayer F, Köhler G, Bonci A, Freissmuth M, Sitte HH. Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy. Molecular Pharmacology. 76: 1196-210. PMID 19755522 DOI: 10.1124/mol.109.059139  0.48
2009 Freissmuth M, Huck S. Austria should invest in brains, not in bricks, banks or airlines. Nature. 458: 571. PMID 19340061 DOI: 10.1038/458571a  0.48
2008 Reiterer V, Maier S, Sitte HH, Kriz A, Rüegg MA, Hauri HP, Freissmuth M, Farhan H. Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12453-64. PMID 19020038 DOI: 10.1523/JNEUROSCI.3451-08.2008  0.48
2008 Zebedin E, Simma O, Schuster C, Putz EM, Fajmann S, Warsch W, Eckelhart E, Stoiber D, Weisz E, Schmid JA, Pickl WF, Baumgartner C, Valent P, Piekorz RP, Freissmuth M, et al. Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. Blood. 112: 4655-64. PMID 18684865 DOI: 10.1182/blood-2008-02-139105  0.36
2008 Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD. Anomalous dopamine release associated with a human dopamine transporter coding variant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7040-6. PMID 18614672 DOI: 10.1523/JNEUROSCI.0473-08.2008  0.48
2008 Steiner I, Errhalt P, Kubesch K, Hubner M, Holy M, Bauer M, Müller M, Hinterberger S, Widmann R, Mascher D, Freissmuth M, Kneussl M. Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers. Naunyn-Schmiedeberg's Archives of Pharmacology. 378: 323-33. PMID 18500510 DOI: 10.1007/s00210-008-0293-8  0.64
2008 Meiblitzer-Ruppitsch C, Vetterlein M, Stangl H, Maier S, Neumüller J, Freissmuth M, Pavelka M, Ellinger A. Electron microscopic visualization of fluorescent signals in cellular compartments and organelles by means of DAB-photoconversion. Histochemistry and Cell Biology. 130: 407-19. PMID 18463889 DOI: 10.1007/s00418-008-0429-4  0.48
2008 Zebedin E, Freissmuth M, Sexl V. Signal interception-based therapies--a double-edged sword in Bcr/abl-induced malignancies? Leukemia & Lymphoma. 49: 620-4. PMID 18398721 DOI: 10.1080/10428190701858872  0.32
2008 Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH. Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies. Journal of Molecular Biology. 378: 337-52. PMID 18367207 DOI: 10.1016/j.jmb.2008.02.056  0.88
2008 Farhan H, Reiterer V, Kriz A, Hauri HP, Pavelka M, Sitte HH, Freissmuth M. Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif. Journal of Cell Science. 121: 753-61. PMID 18285449 DOI: 10.1242/jcs.017681  0.48
2008 Charalambous C, Gsandtner I, Keuerleber S, Milan-Lobo L, Kudlacek O, Freissmuth M, Zezula J. Restricted collision coupling of the A2A receptor revisited: evidence for physical separation of two signaling cascades. The Journal of Biological Chemistry. 283: 9276-88. PMID 18218631 DOI: 10.1074/jbc.M706275200  0.48
2008 Zebedin E, Koenig X, Radenkovic M, Pankevych H, Todt H, Freissmuth M, Hilber K. Effects of duramycin on cardiac voltage-gated ion channels. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 87-100. PMID 18176799 DOI: 10.1007/s00210-007-0248-5  0.48
2008 Schuster C, Müller M, Freissmuth M, Sexl V, Stoiber D. Commentary on H. Ide et al., "Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells". Biochemical and Biophysical Research Communications. 366: 869-70. PMID 18082134 DOI: 10.1016/j.bbrc.2007.12.017  0.32
2007 Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V. Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia? Biochemical Pharmacology. 74: 1424-35. PMID 17709099 DOI: 10.1016/j.bcp.2007.07.017  0.88
2007 Farhan H, Reiterer V, Korkhov VM, Schmid JA, Freissmuth M, Sitte HH. Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D. The Journal of Biological Chemistry. 282: 7679-89. PMID 17210573 DOI: 10.1074/jbc.M609720200  0.88
2006 Farhan H, Schuster C, Klinger M, Weisz E, Waxenecker G, Schuster M, Sexl V, Mudde GC, Freissmuth M, Kircheis R. Inhibition of xenograft tumor growth and down-regulation of ErbB receptors by an antibody directed against Lewis Y antigen. The Journal of Pharmacology and Experimental Therapeutics. 319: 1459-66. PMID 16963623 DOI: 10.1124/jpet.106.107318  0.32
2006 Kovacic B, Stoiber D, Moriggl R, Weisz E, Ott RG, Kreibich R, Levy DE, Beug H, Freissmuth M, Sexl V. STAT1 acts as a tumor promoter for leukemia development Cancer Cell. 10: 77-87. PMID 16843267 DOI: 10.1016/j.ccr.2006.05.025  0.48
2006 Korkhov VM, Holy M, Freissmuth M, Sitte HH. The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle. The Journal of Biological Chemistry. 281: 13439-48. PMID 16527819 DOI: 10.1074/jbc.M511382200  0.88
2006 Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, Ducza E, Ogris E, Boehm S, Freissmuth M, Nanoff C. The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Molecular Pharmacology. 69: 1083-94. PMID 16339847 DOI: 10.1124/mol.105.015818  0.48
2005 Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, Zezula J. Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. The Journal of Biological Chemistry. 280: 31898-905. PMID 16027149 DOI: 10.1074/jbc.M506515200  0.48
2005 Seidel S, Singer EA, Just H, Farhan H, Scholze P, Kudlacek O, Holy M, Koppatz K, Krivanek P, Freissmuth M, Sitte HH. Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Molecular Pharmacology. 67: 140-51. PMID 15615700 DOI: 10.1124/mol.67.1.  0.88
2004 Stoiber D, Kovacic B, Schuster C, Schellack C, Karaghiosoff M, Kreibich R, Weisz E, Artwohl M, Kleine OC, Muller M, Baumgartner-Parzer S, Ghysdael J, Freissmuth M, Sexl V. TYK2 is a key regulator of the surveillance of B lymphoid tumors. The Journal of Clinical Investigation. 114: 1650-8. PMID 15578097 DOI: 10.1172/JCI22315  0.32
2004 Korkhov VM, Farhan H, Freissmuth M, Sitte HH. Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II. The Journal of Biological Chemistry. 279: 55728-36. PMID 15496410 DOI: 10.1074/jbc.M409449200  0.88
2004 Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M, Sitte HH. Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1). The Journal of Biological Chemistry. 279: 28553-63. PMID 15073174 DOI: 10.1074/jbc.M307325200  0.88
2004 Klinger M, Farhan H, Just H, Drobny H, Himmler G, Loibner H, Mudde GC, Freissmuth M, Sexl V. Antibodies directed against Lewis-Y antigen inhibit signaling of Lewis-Y modified ErbB receptors. Cancer Research. 64: 1087-93. PMID 14871842  0.36
2004 Just H, Sitte HH, Schmid JA, Freissmuth M, Kudlacek O. Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter. The Journal of Biological Chemistry. 279: 6650-7. PMID 14660642 DOI: 10.1074/jbc.M306092200  0.88
2003 Sitte HH, Freissmuth M. Oligomer formation by Na+-Cl--coupled neurotransmitter transporters. European Journal of Pharmacology. 479: 229-36. PMID 14612153  0.88
2003 Szremska AP, Kenner L, Weisz E, Ott RG, Passegué E, Artwohl M, Freissmuth M, Stoxreiter R, Theussl HC, Parzer SB, Moriggl R, Wagner EF, Sexl V. JunB inhibits proliferation and transformation in B-lymphoid cells. Blood. 102: 4159-65. PMID 12907453 DOI: 10.1182/blood-2003-03-0915  0.32
2003 Kudlacek O, Just H, Korkhov VM, Vartian N, Klinger M, Pankevych H, Yang Q, Nanoff C, Freissmuth M, Boehm S. The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1317-27. PMID 12784121 DOI: 10.1038/sj.npp.1300181  0.6
Show low-probability matches.