ype Elgersma - Publications

Affiliations: 
Erasmus Medical Center Rotterdam, Rotterdam, Netherlands 
Area:
learning and memory

110 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Rauen KA, Alsaegh A, Ben-Shachar S, Berman Y, Blakeley J, Cordeiro I, Elgersma Y, Evans DG, Fisher MJ, Frayling IM, George J, Huson SM, Kerr B, Khire U, Korf B, et al. First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics. American Journal of Medical Genetics. Part A. PMID 30908877 DOI: 10.1002/ajmg.a.61125  0.52
2019 Ferner RE, Bakker A, Elgersma Y, Evans DGR, Giovannini M, Legius E, Lloyd A, Messiaen LM, Plotkin S, Reilly KM, Schindeler A, Smith MJ, Ullrich NJ, Widemann B, Sherman LS. From process to progress-2017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis. American Journal of Medical Genetics. Part A. PMID 30908866 DOI: 10.1002/ajmg.a.61112  0.52
2018 Sonzogni M, Wallaard I, Santos SS, Kingma J, du Mee D, van Woerden GM, Elgersma Y. A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutants. Molecular Autism. 9: 47. PMID 30220990 DOI: 10.1186/s13229-018-0231-7  0.88
2018 Onori MP, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM. The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function. Human Mutation. PMID 30184290 DOI: 10.1002/humu.23647  0.88
2018 Rotaru DC, van Woerden GM, Wallaard I, Elgersma Y. Adult gene reinstatement restores the electrophysiological deficits of prefrontal cortex layer 5 neurons in a mouse model of Angelman syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30082419 DOI: 10.1523/JNEUROSCI.0083-18.2018  0.88
2017 Wang T, van Woerden GM, Elgersma Y, Borst JGG. Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome. Frontiers in Cellular Neuroscience. 11: 418. PMID 29354033 DOI: 10.3389/fncel.2017.00418  0.88
2017 Bazzigaluppi P, Isenia SC, Haasdijk ED, Elgersma Y, De Zeeuw CI, van der Giessen RS, de Jeu MTG. Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII. Frontiers in Cellular Neuroscience. 11: 397. PMID 29311830 DOI: 10.3389/fncel.2017.00397  0.68
2017 van der Wal L, Bezstarosti K, Sap KA, Dekkers DHW, Rijkers E, Mientjes E, Elgersma Y, Demmers JAA. Improvement of ubiquitylation site detection by Orbitrap mass spectrometry. Journal of Proteomics. PMID 29122726 DOI: 10.1016/j.jprot.2017.10.014  0.64
2017 Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, ... ... Elgersma Y, et al. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. American Journal of Human Genetics. 101: 768-788. PMID 29100089 DOI: 10.1016/j.ajhg.2017.10.003  0.88
2017 Wallace ML, van Woerden GM, Elgersma Y, Smith SL, Philpot BD. UBE3A loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice. Journal of Neurophysiology. jn.00618.2016. PMID 28468997 DOI: 10.1152/jn.00618.2016  0.88
2017 Schreiber J, Grimbergen LA, Overwater I, Vaart TV, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y. Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models. Scientific Reports. 7: 1256. PMID 28455524 DOI: 10.1038/s41598-017-01218-0  0.64
2016 Piochon C, Titley HK, Simmons DH, Grasselli G, Elgersma Y, Hansel C. Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799554 DOI: 10.1073/pnas.1613897113  0.44
2016 Overwater IE, Rietman AB, Bindels-de Heus K, Looman CW, Rizopoulos D, Sibindi TM, Cherian PJ, Jansen FE, Moll HA, Elgersma Y, de Wit MY. Sirolimus for epilepsy in children with tuberous sclerosis complex: A randomized controlled trial. Neurology. PMID 27511181 DOI: 10.1212/WNL.0000000000003077  0.56
2016 Kool MJ, van de Bree JE, Bodde HE, Elgersma Y, van Woerden GM. The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Scientific Reports. 6: 26989. PMID 27244486 DOI: 10.1038/srep26989  0.88
2016 Gouty-Colomer LA, Hosseini B, Marcelo IM, Schreiber J, Slump DE, Yamaguchi S, Houweling AR, Jaarsma D, Elgersma Y, Kushner SA. Arc expression identifies the lateral amygdala fear memory trace. Molecular Psychiatry. PMID 27217149 DOI: 10.1038/mp.2016.91  0.64
2016 Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, Burkitt-Wright E, Chatfield K, Elefteriou F, Elgersma Y, Fisher MJ, Franz D, Gelb BD, Goriely A, Gripp KW, et al. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. American Journal of Medical Genetics. Part A. PMID 27155140 DOI: 10.1002/ajmg.a.37723  1
2016 Judson MC, Wallace ML, Sidorov MS, Burette AC, Gu B, van Woerden GM, King IF, Han JE, Zylka MJ, Elgersma Y, Weinberg RJ, Philpot BD. GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility. Neuron. PMID 27021170 DOI: 10.1016/j.neuron.2016.02.040  1
2016 Tonazzini I, Meucci S, Van Woerden GM, Elgersma Y, Cecchini M. Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates. Advanced Healthcare Materials. PMID 26845073 DOI: 10.1002/adhm.201500815  0.88
2015 van der Vaart T, Rietman AB, Plasschaert E, Legius E, Elgersma Y, Moll HA. Behavioral and cognitive outcomes for clinical trials in children with neurofibromatosis type 1. Neurology. PMID 26519538 DOI: 10.1212/WNL.0000000000002118  1
2015 Omrani A, van Woerden GM, Elgersma Y. Neurofibromin regulates HCN activity in Parvalbumin-positive interneurons. Molecular Psychiatry. 20: 1263. PMID 26487477 DOI: 10.1038/mp.2015.154  0.88
2015 Bruinsma CF, Schonewille M, Gao Z, Aronica EM, Judson MC, Philpot BD, Hoebeek FE, van Woerden GM, De Zeeuw CI, Elgersma Y. Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model. The Journal of Clinical Investigation. 125: 4305-15. PMID 26485287 DOI: 10.1172/JCI83541  1
2015 Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, van Woerden GM, Baarends WM, Elgersma Y. An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression. Human Molecular Genetics. PMID 26476408 DOI: 10.1093/hmg/ddv436  0.88
2015 Elgersma Y. Neurodevelopmental disease: A molecular tightrope. Nature. 526: 50-1. PMID 26432241 DOI: 10.1038/526050b  1
2015 Alves MM, Fuhler GM, Queiroz KC, Scholma J, Goorden S, Anink J, Arnold Spek C, Hoogeveen-Westerveld M, Bruno MJ, Nellist M, Elgersma Y, Aronica E, Peppelenbosch MP. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Scientific Reports. 5: 14534. PMID 26412398 DOI: 10.1038/srep14534  1
2015 Wang T, de Kok L, Willemsen R, Elgersma Y, Borst JG. In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome. Frontiers in Cellular Neuroscience. 9: 234. PMID 26190969 DOI: 10.3389/fncel.2015.00234  1
2015 van der Vaart T, Overwater IE, Oostenbrink R, Moll HA, Elgersma Y. Treatment of Cognitive Deficits in Genetic Disorders: A Systematic Review of Clinical Trials of Diet and Drug Treatments. Jama Neurology. 72: 1052-60. PMID 26168015 DOI: 10.1001/jamaneurol.2015.0443  1
2015 Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y. HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Molecular Psychiatry. PMID 25917366 DOI: 10.1038/mp.2015.48  1
2015 Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, et al. The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach. American Journal of Medical Genetics. Part A. PMID 25900621 DOI: 10.1002/ajmg.a.37089  1
2015 Silva-Santos S, van Woerden GM, Bruinsma CF, Mientjes E, Jolfaei MA, Distel B, Kushner SA, Elgersma Y. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. The Journal of Clinical Investigation. 125: 2069-76. PMID 25866966 DOI: 10.1172/JCI80554  1
2015 Gouty-Colomer LA, Hosseini B, Marcelo IM, Schreiber J, Slump DE, Yamaguchi S, Houweling AR, Jaarsma D, Elgersma Y, Kushner SA. Arc expression identifies the lateral amygdala fear memory trace. Molecular Psychiatry. PMID 25802982 DOI: 10.1038/mp.2015.18  1
2015 Goorden SM, Abs E, Bruinsma CF, Riemslagh FW, van Woerden GM, Elgersma Y. Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments. Human Molecular Genetics. 24: 3390-8. PMID 25759467 DOI: 10.1093/hmg/ddv087  1
2015 Remmelink E, Loos M, Koopmans B, Aarts E, van der Sluis S, Smit AB, Verhage M. A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment. Behavioural Brain Research. 283: 53-60. PMID 25601577 DOI: 10.1016/j.bbr.2015.01.020  1
2014 Loos M, Koopmans B, Aarts E, Maroteaux G, van der Sluis S, Verhage M, Smit AB. Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. Plos One. 9: e108563. PMID 25264768 DOI: 10.1371/journal.pone.0108563  1
2014 Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11919-28. PMID 25186740 DOI: 10.1523/JNEUROSCI.0652-14.2014  1
2014 Achterberg KG, Buitendijk GH, Kool MJ, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA, Elgersma Y. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11180-7. PMID 25143599 DOI: 10.1523/JNEUROSCI.0640-14.2014  1
2014 Gao Z, van Woerden GM, Elgersma Y, De Zeeuw CI, Hoebeek FE. Distinct roles of α- and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells. Frontiers in Cellular Neuroscience. 8: 16. PMID 24550776 DOI: 10.3389/fncel.2014.00016  1
2014 Overwater IE, Rietman AB, Elgersma Y, de Wit MC. Treatment of intractable epilepsy in tuberous sclerosis complex with everolimus is not yet evidence-based. Annals of Neurology. 75: 163-4. PMID 24243580 DOI: 10.1002/ana.24047  1
2014 Tonazzini I, Cecchini A, Elgersma Y, Cecchini M. Interaction of SH-SY5Y cells with nanogratings during neuronal differentiation: comparison with primary neurons. Advanced Healthcare Materials. 3: 581-7. PMID 24115396 DOI: 10.1002/adhm.201300216  1
2013 Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ. Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts. Plos One. 8: e81649. PMID 24303063 DOI: 10.1371/journal.pone.0081649  1
2013 van der Vaart T, Plasschaert E, Rietman AB, Renard M, Oostenbrink R, Vogels A, de Wit MC, Descheemaeker MJ, Vergouwe Y, Catsman-Berrevoets CE, Legius E, Elgersma Y, Moll HA. Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial. The Lancet. Neurology. 12: 1076-83. PMID 24090588 DOI: 10.1016/S1474-4422(13)70227-8  1
2013 Galliano E, Potters JW, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FE. Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12599-618. PMID 23904597 DOI: 10.1523/JNEUROSCI.1642-13.2013  1
2013 Waggener CT, Dupree JL, Elgersma Y, Fuss B. CaMKIIβ regulates oligodendrocyte maturation and CNS myelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10453-8. PMID 23785157 DOI: 10.1523/JNEUROSCI.5875-12.2013  1
2013 Abs E, Goorden SM, Schreiber J, Overwater IE, Hoogeveen-Westerveld M, Bruinsma CF, Aganović E, Borgesius NZ, Nellist M, Elgersma Y. TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice. Annals of Neurology. 74: 569-79. PMID 23720219 DOI: 10.1002/ana.23943  1
2013 Melser S, Chatelain EH, Lavie J, Mahfouf W, Jose C, Obre E, Goorden S, Priault M, Elgersma Y, Rezvani HR, Rossignol R, Bénard G. Rheb regulates mitophagy induced by mitochondrial energetic status. Cell Metabolism. 17: 719-30. PMID 23602449 DOI: 10.1016/j.cmet.2013.03.014  1
2013 Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. Corrigendum to "The Learning Disabilities Network (LeaDNet): Using Neurofibromatosis Type 1 [NF1] as a Paradigm for Translational Research" American Journal of Medical Genetics, Part A. 161: 236. DOI: 10.1002/ajmg.a.35667  1
2012 Castrén E, Elgersma Y, Maffei L, Hagerman R. Treatment of neurodevelopmental disorders in adulthood. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14074-9. PMID 23055475 DOI: 10.1523/JNEUROSCI.3287-12.2012  1
2012 Nagtegaal AP, Spijker S, Crins TT, Borst JG. A novel QTL underlying early-onset, low-frequency hearing loss in BXD recombinant inbred strains. Genes, Brain, and Behavior. 11: 911-20. PMID 22989164 DOI: 10.1111/j.1601-183X.2012.00845.x  1
2012 Acosta MT, Bearden CE, Castellanos FX, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, et al. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American Journal of Medical Genetics. Part A. 158: 2225-32. PMID 22821737 DOI: 10.1002/ajmg.a.35535  1
2012 Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of Biological Chemistry. 287: 29627-35. PMID 22778257 DOI: 10.1074/jbc.M112.367219  1
2012 van Beveren NJ, Krab LC, Swagemakers S, Buitendijk G, Buitendijk GH, Boot E, van der Spek P, Elgersma Y, van Amelsvoort TA. Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome. Plos One. 7: e33473. PMID 22457764 DOI: 10.1371/journal.pone.0033473  1
2012 van Beveren NJ, Buitendijk GH, Swagemakers S, Krab LC, Röder C, de Haan L, van der Spek P, Elgersma Y. Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients. Plos One. 7: e32618. PMID 22393424 DOI: 10.1371/journal.pone.0032618  1
2012 Cho J, Bhatt R, Elgersma Y, Silva AJ. α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns. Plos One. 7: e31649. PMID 22363696 DOI: 10.1371/journal.pone.0031649  1
2012 Loos M, Staal J, Pattij T, Smit AB, Spijker S. Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strains. Genes, Brain, and Behavior. 11: 147-56. PMID 22098762 DOI: 10.1111/j.1601-183X.2011.00754.x  1
2011 Gerestein CG, Eijkemans MJ, Bakker J, Elgersma OE, van der Burg ME, Kooi GS, Burger CW. Nomogram for suboptimal cytoreduction at primary surgery for advanced stage ovarian cancer. Anticancer Research. 31: 4043-9. PMID 22110240  0.32
2011 Borgesius NZ, de Waard MC, van der Pluijm I, Omrani A, Zondag GC, van der Horst GT, Melton DW, Hoeijmakers JH, Jaarsma D, Elgersma Y. Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12543-53. PMID 21880916 DOI: 10.1523/JNEUROSCI.1589-11.2011  1
2011 Papachristos EB, Jacobs EH, Elgersma Y. Interval timing is intact in arrhythmic Cry1/Cry2-deficient mice. Journal of Biological Rhythms. 26: 305-13. PMID 21775289 DOI: 10.1177/0748730411410026  1
2011 Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y. βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10141-8. PMID 21752990 DOI: 10.1523/JNEUROSCI.5105-10.2011  1
2011 Goorden SM, Elgersma Y. Rheb: enrichment beyond the brain. Cell Cycle (Georgetown, Tex.). 10: 2412-3. PMID 21670600 DOI: 10.4161/cc.10.15.16385  1
2011 van der Vaart T, van Woerden GM, Elgersma Y, de Zeeuw CI, Schonewille M. Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum. Genes, Brain, and Behavior. 10: 404-9. PMID 21352477 DOI: 10.1111/j.1601-183X.2011.00685.x  1
2011 Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M, Post L, Duckers HJ, Nellist M, Elgersma Y. Rheb is essential for murine development. Molecular and Cellular Biology. 31: 1672-8. PMID 21321084 DOI: 10.1128/MCB.00985-10  1
2011 Krab LC, de Goede-Bolder A, Aarsen FK, Moll HA, De Zeeuw CI, Elgersma Y, van der Geest JN. Motor learning in children with neurofibromatosis type I. Cerebellum (London, England). 10: 14-21. PMID 20927664 DOI: 10.1007/s12311-010-0217-2  1
2010 Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu MT, Elgersma Y, De Zeeuw CI, Jörntell H, Hansel C. Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13630-43. PMID 20943904 DOI: 10.1523/JNEUROSCI.3226-10.2010  1
2010 Schonewille M, Belmeguenai A, Koekkoek SK, Houtman SH, Boele HJ, van Beugen BJ, Gao Z, Badura A, Ohtsuki G, Amerika WE, Hosy E, Hoebeek FE, Elgersma Y, Hansel C, De Zeeuw CI. Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron. 67: 618-28. PMID 20797538 DOI: 10.1016/j.neuron.2010.07.009  1
2010 de Waard MC, van der Pluijm I, Zuiderveen Borgesius N, Comley LH, Haasdijk ED, Rijksen Y, Ridwan Y, Zondag G, Hoeijmakers JH, Elgersma Y, Gillingwater TH, Jaarsma D. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathologica. 120: 461-75. PMID 20602234 DOI: 10.1007/s00401-010-0715-9  1
2009 van Woerden GM, Hoebeek FE, Gao Z, Nagaraja RY, Hoogenraad CC, Kushner SA, Hansel C, De Zeeuw CI, Elgersma Y. betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature Neuroscience. 12: 823-5. PMID 19503086 DOI: 10.1038/nn.2329  1
2009 Krab LC, Oostenbrink R, de Goede-Bolder A, Aarsen FK, Elgersma Y, Moll HA. Health-related quality of life in children with neurofibromatosis type 1: contribution of demographic factors, disease-related factors, and behavior. The Journal of Pediatrics. 154: 420-5, 425.e1. PMID 18950800 DOI: 10.1016/j.jpeds.2008.08.045  1
2008 Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D. Spred1 is required for synaptic plasticity and hippocampus-dependent learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14443-9. PMID 19118178 DOI: 10.1523/JNEUROSCI.4698-08.2008  1
2008 Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. 135: 549-60. PMID 18984165 DOI: 10.1016/j.cell.2008.09.060  1
2008 Krab LC, Aarsen FK, de Goede-Bolder A, Catsman-Berrevoets CE, Arts WF, Moll HA, Elgersma Y. Impact of neurofibromatosis type 1 on school performance. Journal of Child Neurology. 23: 1002-10. PMID 18827266 DOI: 10.1177/0883073808316366  1
2008 Krab LC, Goorden SM, Elgersma Y. Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases. Trends in Genetics : Tig. 24: 498-510. PMID 18774199 DOI: 10.1016/j.tig.2008.07.005  1
2008 Heimel JA, Hermans JM, Sommeijer JP, Levelt CN. Genetic control of experience-dependent plasticity in the visual cortex. Genes, Brain, and Behavior. 7: 915-23. PMID 18700840 DOI: 10.1111/j.1601-183X.2008.00431.x  1
2008 Krab LC, de Goede-Bolder A, Aarsen FK, Pluijm SM, Bouman MJ, van der Geest JN, Lequin M, Catsman CE, Arts WF, Kushner SA, Silva AJ, de Zeeuw CI, Moll HA, Elgersma Y. Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. Jama. 300: 287-94. PMID 18632543 DOI: 10.1001/jama.300.3.287  1
2008 Olijslagers JE, de Kloet ER, Elgersma Y, van Woerden GM, Joëls M, Karst H. Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors. The European Journal of Neuroscience. 27: 2542-50. PMID 18547242 DOI: 10.1111/j.1460-9568.2008.06220.x  1
2008 van Engelen SJ, Krab LC, Moll HA, de Goede-Bolder A, Pluijm SM, Catsman-Berrevoets CE, Elgersma Y, Lequin MH. Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging. Ajnr. American Journal of Neuroradiology. 29: 816-22. PMID 18339726 DOI: 10.3174/ajnr.A0921  1
2008 Park CS, Elgersma Y, Grant SG, Morrison JH. alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus. Neuroscience. 151: 43-55. PMID 18082335 DOI: 10.1016/j.neuroscience.2007.09.075  1
2008 Shilyansky C, Li W, Acosta M, Elgersma Y, Hannan F, Hardt M, Hunter-Schaedle K, Krab LC, Legius E, Wiltgen B, J Silva A. Molecular and cellular mechanisms of learning disabilities: A focus on neurofibromatosis type I Animal and Translational Models For Cns Drug Discovery. 2: 77-92. DOI: 10.1016/B978-0-12-373861-5.00015-1  1
2008 Elgersma Y, Krab LC, Moll HA. Statin therapy and cognitive deficits associated with neurofibromatosis type 1: Reply Jama - Journal of the American Medical Association. 300: 2369-2370. DOI: 10.1001/jama.2008.688  1
2007 Goorden SM, van Woerden GM, van der Weerd L, Cheadle JP, Elgersma Y. Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures. Annals of Neurology. 62: 648-55. PMID 18067135 DOI: 10.1002/ana.21317  1
2007 Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nature Neuroscience. 10: 1125-7. PMID 17660813 DOI: 10.1038/nn1946  1
2007 Elgersma Y. Genetic engineering cures mice of neurological deficits: prospects for treating Angelman syndrome. Pharmacogenomics. 8: 539-41. PMID 17559342 DOI: 10.2217/14622416.8.6.539  1
2007 van Woerden GM, Harris KD, Hojjati MR, Gustin RM, Qiu S, de Avila Freire R, Jiang YH, Elgersma Y, Weeber EJ. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nature Neuroscience. 10: 280-2. PMID 17259980 DOI: 10.1038/nn1845  1
2006 Hansel C, de Jeu M, Belmeguenai A, Houtman SH, Buitendijk GH, Andreev D, De Zeeuw CI, Elgersma Y. alphaCaMKII Is essential for cerebellar LTD and motor learning. Neuron. 51: 835-43. PMID 16982427 DOI: 10.1016/j.neuron.2006.08.013  1
2005 Kushner SA, Elgersma Y, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ. Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9721-34. PMID 16237176 DOI: 10.1523/JNEUROSCI.2836-05.2005  1
2005 Burguière E, Arleo A, Hojjati Mr, Elgersma Y, De Zeeuw CI, Berthoz A, Rondi-Reig L. Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit? Nature Neuroscience. 8: 1292-4. PMID 16136042 DOI: 10.1038/nn1532  1
2005 Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan-Vaughan D, Elgersma Y, Beck H. Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7697-707. PMID 16107656 DOI: 10.1523/JNEUROSCI.2086-05.2005  1
2004 Elgersma Y, Sweatt JD, Giese KP. Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8410-5. PMID 15456813 DOI: 10.1523/JNEUROSCI.3622-04.2004  1
2003 Koekkoek SK, Hulscher HC, Dortland BR, Hensbroek RA, Elgersma Y, Ruigrok TJ, De Zeeuw CI. Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. Science (New York, N.Y.). 301: 1736-9. PMID 14500987 DOI: 10.1126/science.1088383  1
2003 Weeber EJ, Jiang YH, Elgersma Y, Varga AW, Carrasquillo Y, Brown SE, Christian JM, Mirnikjoo B, Silva A, Beaudet AL, Sweatt JD. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2634-44. PMID 12684449  1
2002 Kistler WM, De Jeu MT, Elgersma Y, Van Der Giessen RS, Hensbroek R, Luo C, Koekkoek SK, Hoogenraad CC, Hamers FP, Gueldenagel M, Sohl G, Willecke K, De Zeeuw CI. Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance. Annals of the New York Academy of Sciences. 978: 391-404. PMID 12582068 DOI: 10.1111/j.1749-6632.2002.tb07582.x  1
2002 Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 36: 493-505. PMID 12408851 DOI: 10.1016/S0896-6273(02)01007-3  1
2001 Silva AJ, Elgersma Y, Costa RM. From genes to therapies: The role of animal models Clinical Neuroscience Research. 1: 187-193. DOI: 10.1016/S1566-2772(01)00005-6  1
2000 Distel B, Braakman I, Elgersma Y, Tabak HF. Transactions at the peroxisomal membrane. Sub-Cellular Biochemistry. 34: 303-22. PMID 10808337  1
2000 Silva AJ, Elgersma Y, Costa RM. Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders. Biological Psychiatry. 47: 200-9. PMID 10682217 DOI: 10.1016/S0006-3223(99)00294-2  1
1999 Elgersma Y, Silva AJ. Molecular mechanisms of synaptic plasticity and memory. Current Opinion in Neurobiology. 9: 209-13. PMID 10322188 DOI: 10.1016/S0959-4388(99)80029-4  1
1998 Silva AJ, Elgersma Y, Friedman E, Stern J, Kogan J. A mouse model for learning and memory defects associated with neurofibromatosis type I. Pathologie-Biologie. 46: 697-8. PMID 9885821  1
1998 Faber KN, Elgersma Y, Heyman JA, Koller A, Lüers GH, Nuttley WM, Terlecky SR, Wenzel TJ, Subramani S. Use of Pichia pastoris as a model eukaryotic system. Peroxisome biogenesis. Methods in Molecular Biology (Clifton, N.J.). 103: 121-47. PMID 9680638 DOI: 10.1385/0-89603-421-6:121  1
1998 Elgersma Y, Elgersma-Hooisma M, Wenzel T, McCaffery JM, Farquhar MG, Subramani S. A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris. The Journal of Cell Biology. 140: 807-20. PMID 9472033 DOI: 10.1083/jcb.140.4.807  1
1997 Elgersma Y, Kwast L, van den Berg M, Snyder WB, Distel B, Subramani S, Tabak HF. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane. The Embo Journal. 16: 7326-41. PMID 9405362 DOI: 10.1093/emboj/16.24.7326  1
1997 Verleur N, Elgersma Y, Van Roermund CW, Tabak HF, Wanders RJ. Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae. European Journal of Biochemistry / Febs. 247: 972-80. PMID 9288922  1
1996 Elgersma Y, Tabak HF. Proteins involved in peroxisome biogenesis and functioning. Biochimica Et Biophysica Acta. 1286: 269-83. PMID 8982286 DOI: 10.1016/S0304-4157(96)00012-3  1
1996 Elgersma Y, Kwast L, Klein A, Voorn-Brouwer T, van den Berg M, Metzig B, America T, Tabak HF, Distel B. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. The Journal of Cell Biology. 135: 97-109. PMID 8858166 DOI: 10.1083/jcb.135.1.97  1
1996 Elgersma Y, Vos A, van den Berg M, van Roermund CW, van der Sluijs P, Distel B, Tabak HF. Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 271: 26375-82. PMID 8824293 DOI: 10.1074/jbc.271.42.26375  1
1995 Tabak HF, Elgersma Y, Hettema E, Franse MM, Voorn-Brouwer T, Distel B. Transport of proteins and metabolites across the impermeable membrane of peroxisomes. Cold Spring Harbor Symposia On Quantitative Biology. 60: 649-55. PMID 8824438  1
1995 van Roermund CW, Elgersma Y, Singh N, Wanders RJ, Tabak HF. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. The Embo Journal. 14: 3480-6. PMID 7628449  1
1995 Elgersma Y, van Roermund CW, Wanders RJ, Tabak HF. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. The Embo Journal. 14: 3472-9. PMID 7628448  1
1993 Van der Leij I, Franse MM, Elgersma Y, Distel B, Tabak HF. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 90: 11782-6. PMID 8265627 DOI: 10.1073/pnas.90.24.11782  1
1993 Elgersma Y, van den Berg M, Tabak HF, Distel B. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Genetics. 135: 731-40. PMID 7507454  1
1991 Vink C, van Gent DC, Elgersma Y, Plasterk RH. Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage. Journal of Virology. 65: 4636-44. PMID 1870194  1
1991 van Gent DC, Elgersma Y, Bolk MW, Vink C, Plasterk RH. DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2. Nucleic Acids Research. 19: 3821-7. PMID 1861975  1
1990 Vink C, Groenink M, Elgersma Y, Fouchier RA, Tersmette M, Plasterk RH. Analysis of the junctions between human immunodeficiency virus type 1 proviral DNA and human DNA. Journal of Virology. 64: 5626-7. PMID 2214029  1
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