Henk Roelink - Publications

University of Washington, Seattle, Seattle, WA 
 Molecular and Cell Biology University of California, Berkeley, Berkeley, CA 
Induction in vertebrate development and ES cell differentiation

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Roberts B, Casillas C, Alfaro AC, Jägers C, Roelink H. Patched1 and Patched2 inhibit Smoothened non-cell autonomously. Elife. 5. PMID 27552050 DOI: 10.7554/eLife.17634  1
2014 Kwong L, Bijlsma MF, Roelink H. Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling. Nature Communications. 5: 4849. PMID 25215859 DOI: 10.1038/ncomms5849  1
2014 Alfaro AC, Roberts B, Kwong L, Bijlsma MF, Roelink H. Ptch2 mediates the Shh response in Ptch1-/- cells. Development (Cambridge, England). 141: 3331-9. PMID 25085974 DOI: 10.1242/dev.110056  1
2014 Herrera FJ, Yamaguchi T, Roelink H, Tjian R. Core promoter factor TAF9B regulates neuronal gene expression. Elife. 3: e02559. PMID 25006164 DOI: 10.7554/eLife.02559.001  1
2013 Damhofer H, Medema JP, Veenstra VL, Badea L, Popescu I, Roelink H, Bijlsma MF. Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. Molecular Oncology. 7: 1031-42. PMID 23998958 DOI: 10.1016/j.molonc.2013.08.004  1
2012 Bijlsma MF, Damhofer H, Roelink H. Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium. Science Signaling. 5: ra60. PMID 22912493 DOI: 10.1126/scisignal.2002798  1
2010 Shum AS, Tang LS, Copp AJ, Roelink H. Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 3192-203. PMID 20960561 DOI: 10.1002/dvdy.22457  1
2010 Bijlsma MF, Roelink H. Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets. Expert Opinion On Therapeutic Targets. 14: 693-702. PMID 20515293 DOI: 10.1517/14728222.2010.497488  1
2010 Etheridge LA, Crawford TQ, Zhang S, Roelink H. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development (Cambridge, England). 137: 133-40. PMID 20023168 DOI: 10.1242/dev.043547  1
2010 Roelink H. Sonic Hedgehog and Neural Patterning Encyclopedia of Neuroscience. 129-136. DOI: 10.1016/B978-008045046-9.01059-7  1
2008 Kolesová H, Roelink H, Grim M. Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 1923-34. PMID 18570256 DOI: 10.1002/dvdy.21608  1
2008 Bijlsma MF, Peppelenbosch MP, Spek CA, Roelink H. Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation. Stem Cells (Dayton, Ohio). 26: 1138-45. PMID 18292210 DOI: 10.1634/stemcells.2007-0841  1
2007 Bijlsma MF, Borensztajn KS, Roelink H, Peppelenbosch MP, Spek CA. Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cellular Signalling. 19: 2596-604. PMID 17884337 DOI: 10.1016/j.cellsig.2007.08.011  1
2007 Crawford TQ, Roelink H. The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 886-92. PMID 17295317 DOI: 10.1002/dvdy.21083  1
2006 Christensen C, Zhang S, Roelink H. Inhibition of cGMP-dependent protein kinase reduces the response to sonic hedgehog in neuralized embryoid bodies. Stem Cells and Development. 15: 647-54. PMID 17105400 DOI: 10.1089/scd.2006.15.647  1
2006 Mizutani CM, Meyer N, Roelink H, Bier E. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. Plos Biology. 4: e313. PMID 16968133 DOI: 10.1371/journal.pbio.0040313  1
2005 Dooley J, Erickson M, Roelink H, Farr AG. Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 233: 1605-12. PMID 15986478 DOI: 10.1002/dvdy.20495  1
2004 Robertson CP, Braun MM, Roelink H. Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3-like signal. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 229: 510-9. PMID 14991707 DOI: 10.1002/dvdy.10501  1
2003 Braun MM, Etheridge A, Bernard A, Robertson CP, Roelink H. Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain. Development (Cambridge, England). 130: 5579-87. PMID 14522868 DOI: 10.1242/dev.00685  1
2003 Meyer NP, Roelink H. The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord. Developmental Biology. 257: 343-55. PMID 12729563 DOI: 10.1016/S0012-1606(03)00065-4  1
2002 Incardona JP, Gruenberg J, Roelink H. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Current Biology : Cb. 12: 983-95. PMID 12123571 DOI: 10.1016/S0960-9822(02)00895-3  1
2002 Huang Y, Roelink H, McKnight GS. Protein kinase A deficiency causes axially localized neural tube defects in mice. The Journal of Biological Chemistry. 277: 19889-96. PMID 11886853 DOI: 10.1074/jbc.M111412200  1
2001 Robertson CP, Gibbs SM, Roelink H. cGMP enhances the sonic hedgehog response in neural plate cells. Developmental Biology. 238: 157-67. PMID 11784001 DOI: 10.1006/dbio.2001.0392  1
2000 Incardona JP, Roelink H. The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. Cellular and Molecular Life Sciences : Cmls. 57: 1709-19. PMID 11130177  1
2000 Incardona JP, Lee JH, Robertson CP, Enga K, Kapur RP, Roelink H. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proceedings of the National Academy of Sciences of the United States of America. 97: 12044-9. PMID 11027307 DOI: 10.1073/pnas.220251997  1
2000 Incardona JP, Gaffield W, Lange Y, Cooney A, Pentchev PG, Liu S, Watson JA, Kapur RP, Roelink H. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Developmental Biology. 224: 440-52. PMID 10926779 DOI: 10.1006/dbio.2000.9775  1
2000 Roelink H. Hippocampus formation: an intriguing collaboration. Current Biology : Cb. 10: R279-81. PMID 10753739 DOI: 10.1016/S0960-9822(00)00407-3  1
1999 Gaffield W, Incardona JP, Kapur RP, Roelink H. A looking glass perspective: thalidomide and cyclopamine. Cellular and Molecular Biology (Noisy-Le-Grand, France). 45: 579-88. PMID 10512190  1
1999 Jasoni C, Hendrickson A, Roelink H. Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 215: 215-24. PMID 10398532 DOI: 10.1002/(SICI)1097-0177(199907)215:3<215::AID-AJA4>3.0.CO;2-W  1
1999 Millar SE, Willert K, Salinas PC, Roelink H, Nusse R, Sussman DJ, Barsh GS. WNT signaling in the control of hair growth and structure. Developmental Biology. 207: 133-49. PMID 10049570 DOI: 10.1006/dbio.1998.9140  1
1999 Gaffield W, Incardona JP, Kapur RP, Roelink H. Mechanistic investigation of Veratrum alkaloid-induced mammalian teratogenesis Acs Symposium Series. 745: 173-187.  1
1998 Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (Cambridge, England). 125: 3553-62. PMID 9716521  1
1997 Levine EM, Roelink H, Turner J, Reh TA. Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6277-88. PMID 9236238  1
1996 Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell. 87: 661-73. PMID 8929535 DOI: 10.1016/S0092-8674(00)81386-0  1
1996 Roelink H. Tripartite signaling of pattern: interactions between Hedgehogs, BMPs and Wnts in the control of vertebrate development. Current Opinion in Neurobiology. 6: 33-40. PMID 8794053 DOI: 10.1016/S0959-4388(96)80006-7  1
1996 Pringle NP, Yu WP, Guthrie S, Roelink H, Lumsden A, Peterson AC, Richardson WD. Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Developmental Biology. 177: 30-42. PMID 8660874 DOI: 10.1006/dbio.1996.0142  1
1996 Roelink H, Tanabe Y, Jessell TM. Sonic hedgehog: A mediator of inductive signaling in the neural ventral tube Seminars in Cell and Developmental Biology. 7: 121-127. DOI: 10.1006/scdb.1996.0017  1
1995 Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell. 81: 445-55. PMID 7736596 DOI: 10.1016/0092-8674(95)90397-6  1
1995 Liem KF, Tremml G, Roelink H, Jessell TM. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell. 82: 969-79. PMID 7553857 DOI: 10.1016/0092-8674(95)90276-7  1
1995 Tanabe Y, Roelink H, Jessell TM. Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Current Biology : Cb. 5: 651-8. PMID 7552176 DOI: 10.1016/S0960-9822(95)00130-8  1
1995 Ruiz i Altaba A, Jessell TM, Roelink H. Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Molecular and Cellular Neurosciences. 6: 106-21. PMID 7551564 DOI: 10.1006/mcne.1995.1011  1
1994 Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz i Altaba A, Tanabe Y, Placzek M, Edlund T, Jessell TM. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell. 76: 761-75. PMID 8124714 DOI: 10.1016/0092-8674(94)90514-2  1
1993 Roelink H, Wang J, Black DM, Solomon E, Nusse R. Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. Genomics. 17: 790-2. PMID 8244403 DOI: 10.1006/geno.1993.1412  1
1992 Roelink H, Wagenaar E, Nusse R. Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene. 7: 487-92. PMID 1549363  1
1991 Roelink H, Nusse R. Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes & Development. 5: 381-8. PMID 2001840  1
1990 Roelink H, Wagenaar E, Lopes da Silva S, Nusse R. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proceedings of the National Academy of Sciences of the United States of America. 87: 4519-23. PMID 2162045 DOI: 10.1073/pnas.87.12.4519  1
1989 Schuuring E, van Deemter L, Roelink H, Nusse R. Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells. Molecular and Cellular Biology. 9: 1357-61. PMID 2657391  1
1981 Den Otter G, Duursma SA, Voorneman-Hammelburg R, Roelink H. Postgraduate training of surgical specialists Medisch Contact. 36: 1199-1200.  1
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