| Year |
Citation |
Score |
| 2024 |
Panagaki F, Tapia-Rojo R, Zhu T, Milmoe N, Paracuellos P, Board S, Mora M, Walker J, Rostkova E, Stannard A, Infante E, Garcia-Manyes S. Structural anisotropy results in mechano-directional transport of proteins across nuclear pores. Nature Physics. 20: 1180-1193. PMID 39036650 DOI: 10.1038/s41567-024-02438-8 |
0.719 |
|
| 2024 |
Tapia-Rojo R, Mora M, Garcia-Manyes S. Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales. Nature Protocols. PMID 38467905 DOI: 10.1038/s41596-024-00965-5 |
0.806 |
|
| 2024 |
Darrigrand JF, Salowka A, Torres-Cano A, Tapia-Rojo R, Zhu T, Garcia-Manyes S, Spagnoli FM. Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner. Developmental Cell. PMID 38237591 DOI: 10.1016/j.devcel.2023.12.011 |
0.667 |
|
| 2023 |
Mora M, Tapia-Rojo R, Garcia-Manyes S. Unfolding and Refolding Proteins Using Single-Molecule AFM. Methods in Molecular Biology (Clifton, N.J.). 2694: 339-354. PMID 37824012 DOI: 10.1007/978-1-0716-3377-9_16 |
0.81 |
|
| 2023 |
Bernabé-Rubio M, Ali S, Bhosale PG, Goss G, Mobasseri SA, Tapia-Rojo R, Zhu T, Hiratsuka T, Battilocchi M, Tomás IM, Ganier C, Garcia-Manyes S, Watt FM. Myc-dependent dedifferentiation of Gata6 epidermal cells resembles reversal of terminal differentiation. Nature Cell Biology. PMID 37735598 DOI: 10.1038/s41556-023-01234-5 |
0.662 |
|
| 2023 |
Franz F, Tapia-Rojo R, Winograd-Katz S, Boujemaa-Paterski R, Li W, Unger T, Albeck S, Aponte-Santamaria C, Garcia-Manyes S, Medalia O, Geiger B, Gräter F. Allosteric activation of vinculin by talin. Nature Communications. 14: 4311. PMID 37463895 DOI: 10.1038/s41467-023-39646-4 |
0.762 |
|
| 2022 |
Beedle AE, Garcia-Manyes S. The role of single protein elasticity in mechanobiology. Nature Reviews. Materials. 8: 10-24. PMID 37469679 DOI: 10.1038/s41578-022-00488-z |
0.486 |
|
| 2022 |
Tapia-Rojo R, Mora M, Board S, Walker J, Boujemaa-Paterski R, Medalia O, Garcia-Manyes S. Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape. Nature Physics. 19: 52-60. PMID 36660164 DOI: 10.1038/s41567-022-01808-4 |
0.764 |
|
| 2022 |
Andreu I, Granero-Moya I, Garcia-Manyes S, Roca-Cusachs P. Understanding the role of mechanics in nucleocytoplasmic transport. Apl Bioengineering. 6: 020901. PMID 35783457 DOI: 10.1063/5.0076034 |
0.314 |
|
| 2022 |
Mora M, Board S, Languin-Cattoën O, Masino L, Stirnemann G, Garcia-Manyes S. A Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges. Nano Letters. 22: 3922-3930. PMID 35549281 DOI: 10.1021/acs.nanolett.2c00043 |
0.434 |
|
| 2021 |
Wallis SS, Ventimiglia LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M. The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair. Developmental Cell. 56: 3192-3202.e8. PMID 34818527 DOI: 10.1016/j.devcel.2021.10.022 |
0.31 |
|
| 2021 |
Stannard A, Mora M, Beedle AEM, Castro-López M, Board S, Garcia-Manyes S. Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations. Nano Letters. 21: 2953-2961. PMID 33765390 DOI: 10.1021/acs.nanolett.1c00051 |
0.554 |
|
| 2020 |
Mora M, Stannard A, Garcia-Manyes S. The nanomechanics of individual proteins. Chemical Society Reviews. PMID 32929436 DOI: 10.1039/D0Cs00426J |
0.602 |
|
| 2019 |
Infante E, Stannard A, Board SJ, Rico-Lastres P, Panagaki F, Beedle AEM, Rajan VS, Rostkova E, Lezamiz A, Wang YJ, Breen SG, Shanahan C, Roca-Cusachs P, Garcia-Manyes S. The mechanical stability of proteins regulates their translocation rate into the cell nucleus. Nature Physics. 15: 973-981. PMID 37484710 DOI: 10.1038/s41567-019-0551-3 |
0.321 |
|
| 2019 |
Mobasseri SA, Zijl S, Salameti V, Walko G, Stannard A, Garcia-Manyes S, Watt FM. Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness. Acta Biomaterialia. PMID 30710711 DOI: 10.1016/J.Actbio.2019.01.063 |
0.309 |
|
| 2019 |
Infante E, Stannard A, Board SJ, Rico-Lastres P, Rostkova E, Beedle AEM, Lezamiz A, Wang YJ, Gulaidi Breen S, Panagaki F, Sundar Rajan V, Shanahan C, Roca-Cusachs P, Garcia-Manyes S. The mechanical stability of proteins regulates their translocation rate into the cell nucleus Nature Physics. 15: 973-981. DOI: 10.1038/S41567-019-0551-3 |
0.442 |
|
| 2018 |
Beedle AEM, Mora M, Davis CT, Snijders AP, Stirnemann G, Garcia-Manyes S. Forcing the reversibility of a mechanochemical reaction. Nature Communications. 9: 3155. PMID 30089863 DOI: 10.1038/S41467-018-05115-6 |
0.519 |
|
| 2018 |
Wang Y, Rico-Lastres P, Lezamiz A, Mora M, Solsona C, Stirnemann G, Garcia-Manyes S. DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43. The Journal of Physical Chemistry Letters. PMID 29924934 DOI: 10.1021/Acs.Jpclett.8B01494 |
0.491 |
|
| 2018 |
Perales-Calvo J, Giganti D, Stirnemann G, Garcia-Manyes S. The force-dependent mechanism of DnaK-mediated mechanical folding. Science Advances. 4: eaaq0243. PMID 29487911 DOI: 10.1126/Sciadv.Aaq0243 |
0.589 |
|
| 2017 |
Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. PMID 29107331 DOI: 10.1016/J.Cell.2017.10.008 |
0.399 |
|
| 2017 |
Beedle AEM, Mora M, Lynham S, Stirnemann G, Garcia-Manyes S. Tailoring protein nanomechanics with chemical reactivity. Nature Communications. 8: 15658. PMID 28585528 DOI: 10.1038/Ncomms15658 |
0.533 |
|
| 2017 |
Relat-Goberna J, Beedle AEM, Garcia-Manyes S. The Nanomechanics of Lipid Multibilayer Stacks Exhibits Complex Dynamics. Small (Weinheim An Der Bergstrasse, Germany). 13. PMID 28503797 DOI: 10.1002/Smll.201700147 |
0.451 |
|
| 2017 |
Garcia-Manyes S, Beedle AEM. Steering chemical reactions with force Nature Reviews Chemistry. 1. DOI: 10.1038/S41570-017-0083 |
0.333 |
|
| 2016 |
Pernigo S, Fukuzawa A, Beedle AE, Holt M, Round A, Pandini A, Garcia-Manyes S, Gautel M, Steiner RA. Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. Structure (London, England : 1993). PMID 27989621 DOI: 10.1016/J.Str.2016.11.015 |
0.403 |
|
| 2016 |
Beedle AE, Lynham S, Garcia-Manyes S. Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding. Nature Communications. 7: 12490. PMID 27546612 DOI: 10.1038/Ncomms12490 |
0.515 |
|
| 2016 |
Perales-Calvo J, Giganti D, Garcia-Manyes S. Chaperone-Mediated Mechanical Protein Folding at the Single Molecule Level Biophysical Journal. 110: 392a. DOI: 10.1016/J.Bpj.2015.11.2120 |
0.502 |
|
| 2016 |
Beedle AE, Garcia-Manyes S. Linking Mechanochemistry to Protein Folding at the Single Bond Level Biophysical Journal. 110: 181a. DOI: 10.1016/J.Bpj.2015.11.1009 |
0.478 |
|
| 2015 |
Garcia-Manyes S, Giganti D, Badilla CL, Lezamiz A, Perales-Calvo J, Beedle AE, Fernández JM. Single molecule force spectroscopy predicts a misfolded, domain-swapped conformation in human γD-crystallin. The Journal of Biological Chemistry. PMID 26703476 DOI: 10.1074/Jbc.M115.673871 |
0.702 |
|
| 2015 |
Beedle AE, Williams A, Relat-Goberna J, Garcia-Manyes S. Mechanobiology-chemical origin of membrane mechanical resistance and force-dependent signaling. Current Opinion in Chemical Biology. 29: 87-93. PMID 26517566 DOI: 10.1016/J.Cbpa.2015.09.019 |
0.475 |
|
| 2015 |
Perales-Calvo J, Lezamiz A, Garcia-Manyes S. The Mechanochemistry of a Structural Zinc Finger. The Journal of Physical Chemistry Letters. 6: 3335-40. PMID 26296179 DOI: 10.1021/Acs.Jpclett.5B01371 |
0.505 |
|
| 2015 |
Beedle AE, Lezamiz A, Stirnemann G, Garcia-Manyes S. The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins. Nature Communications. 6: 7894. PMID 26235284 DOI: 10.1038/Ncomms8894 |
0.538 |
|
| 2015 |
Relat-Goberna J, Garcia-Manyes S. Direct Observation of the Dynamics of Self-Assembly of Individual Solvation Layers in Molecularly Confined Liquids. Physical Review Letters. 114: 258303. PMID 26197150 DOI: 10.1103/Physrevlett.114.258303 |
0.316 |
|
| 2013 |
Popa I, Kosuri P, Alegre-Cebollada J, Garcia-Manyes S, Fernandez JM. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. Nature Protocols. 8: 1261-76. PMID 23744288 DOI: 10.1038/Nprot.2013.056 |
0.801 |
|
| 2012 |
Berkovich R, Hermans RI, Popa I, Stirnemann G, Garcia-Manyes S, Berne BJ, Fernandez JM. Rate limit of protein elastic response is tether dependent. Proceedings of the National Academy of Sciences of the United States of America. 109: 14416-21. PMID 22895787 DOI: 10.1073/Pnas.1212167109 |
0.797 |
|
| 2012 |
Garcia-Manyes S, Badilla CL, Alegre-Cebollada J, Javadi Y, Fernández JM. Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring. The Journal of Biological Chemistry. 287: 20240-7. PMID 22523089 DOI: 10.1074/Jbc.M112.355883 |
0.805 |
|
| 2012 |
Berkovich R, Hermans RI, Garcia-Manyes S, Fernandez JM. Direct Measurement of the Diffusion Dynamics of an Extended Poly-Ubiquitin Under Constant Force Biophysical Journal. 102: 12a. DOI: 10.1016/J.Bpj.2011.11.090 |
0.819 |
|
| 2011 |
Popa I, Fernández JM, Garcia-Manyes S. Direct quantification of the attempt frequency determining the mechanical unfolding of ubiquitin protein. The Journal of Biological Chemistry. 286: 31072-9. PMID 21768096 DOI: 10.1074/Jbc.M111.264093 |
0.798 |
|
| 2011 |
Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nature Structural & Molecular Biology. 18: 592-6. PMID 21460845 DOI: 10.1038/Nsmb.2020 |
0.756 |
|
| 2011 |
Garcia-Manyes S, Kuo TL, Fernández JM. Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein. Journal of the American Chemical Society. 133: 3104-13. PMID 21309561 DOI: 10.1021/Ja109865Z |
0.697 |
|
| 2011 |
Berkovich R, Garcia-Manyes S, Klafter J, Urbakh M, Fernandez JM. An Intrusive Entropic Barrier Induced by Force Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3066 |
0.615 |
|
| 2011 |
Garcia-Manyes S, Kuo T, Fernández JM. Protein Unfolding and Chemical Reactions Under Force: Complexity Versus Simplicity Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2815 |
0.53 |
|
| 2011 |
Popa I, Garcia-Manyes S, Fernandez JM. Temperature Dependence of the Mechanical Unfolding of Single Ubiquitin Proteins Biophysical Journal. 100: 398a. DOI: 10.1016/J.Bpj.2010.12.2362 |
0.801 |
|
| 2010 |
Berkovich R, Garcia-Manyes S, Klafter J, Urbakh M, Fernández JM. Hopping around an entropic barrier created by force. Biochemical and Biophysical Research Communications. 403: 133-7. PMID 21050839 DOI: 10.1016/J.Bbrc.2010.10.133 |
0.728 |
|
| 2010 |
Garcia-Manyes S. Single-molecule kinetics: Caught in the act. Nature Chemistry. 2: 905-6. PMID 20966939 DOI: 10.1038/Nchem.882 |
0.366 |
|
| 2010 |
Garcia-Manyes S, Redondo-Morata L, Oncins G, Sanz F. Nanomechanics of lipid bilayers: heads or tails? Journal of the American Chemical Society. 132: 12874-86. PMID 20799688 DOI: 10.1021/Ja1002185 |
0.416 |
|
| 2010 |
Kuo TL, Garcia-Manyes S, Li J, Barel I, Lu H, Berne BJ, Urbakh M, Klafter J, Fernández JM. Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 107: 11336-40. PMID 20534507 DOI: 10.1073/Pnas.1006517107 |
0.697 |
|
| 2010 |
Berkovich R, Garcia-Manyes S, Urbakh M, Klafter J, Fernandez JM. Collapse dynamics of single proteins extended by force. Biophysical Journal. 98: 2692-701. PMID 20513414 DOI: 10.1016/J.Bpj.2010.02.053 |
0.729 |
|
| 2010 |
Garcia-Manyes S, Sanz F. Nanomechanics of lipid bilayers by force spectroscopy with AFM: a perspective. Biochimica Et Biophysica Acta. 1798: 741-9. PMID 20044974 DOI: 10.1016/J.Bbamem.2009.12.019 |
0.376 |
|
| 2009 |
Garcia-Manyes S, Liang J, Szoszkiewicz R, Kuo TL, Fernández JM. Force-activated reactivity switch in a bimolecular chemical reaction. Nature Chemistry. 1: 236-42. PMID 21378854 DOI: 10.1038/Nchem.207 |
0.709 |
|
| 2009 |
Grützner A, Garcia-Manyes S, Kötter S, Badilla CL, Fernandez JM, Linke WA. Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophysical Journal. 97: 825-34. PMID 19651040 DOI: 10.1016/J.Bpj.2009.05.037 |
0.611 |
|
| 2009 |
Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernández JM. Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin. Proceedings of the National Academy of Sciences of the United States of America. 106: 10534-9. PMID 19541635 DOI: 10.1073/Pnas.0901213106 |
0.803 |
|
| 2009 |
Garcia-Manyes S, Dougan L, Fernández JM. Osmolyte-induced separation of the mechanical folding phases of ubiquitin. Proceedings of the National Academy of Sciences of the United States of America. 106: 10540-5. PMID 19541633 DOI: 10.1073/Pnas.0902090106 |
0.794 |
|
| 2009 |
Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernández JM. Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry. Biophysical Journal. 96: 3810-21. PMID 19413987 DOI: 10.1016/J.Bpj.2009.01.043 |
0.738 |
|
| 2009 |
Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernandez JM. Platform AY: Emerging Single Molecule Techniques IIMechanical characterization of Protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry Biophysical Journal. DOI: 10.1016/J.Bpj.2008.12.3650 |
0.67 |
|
| 2009 |
Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernandez J. Revisiting Protein Folding at the Single Molecule Level Biophysical Journal. 96: 217a. DOI: 10.1016/J.Bpj.2008.12.1903 |
0.798 |
|
| 2009 |
Garcia-Manyes S, Liang J, Fernandez JM. Direct Identification of Two Distinct Transition State Structures in Reduction of a Disulfide Bond Revealed by Single Bond Force-clamp Spectroscopy Biophysical Journal. 96: 37a. DOI: 10.1016/J.Bpj.2008.12.085 |
0.66 |
|
| 2007 |
Oncins G, Picas L, Hernández-Borrell J, Garcia-Manyes S, Sanz F. Thermal response of Langmuir-Blodgett films of dipalmitoylphosphatidylcholine studied by atomic force microscopy and force spectroscopy. Biophysical Journal. 93: 2713-25. PMID 17586574 DOI: 10.1529/Biophysj.107.110916 |
0.4 |
|
| 2007 |
Garcia-Manyes S, Brujić J, Badilla CL, Fernández JM. Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin. Biophysical Journal. 93: 2436-46. PMID 17545242 DOI: 10.1529/Biophysj.107.104422 |
0.744 |
|
| 2007 |
Garcia-Manyes S, Domènech O, Sanz F, Montero MT, Hernandez-Borrell J. Atomic force microscopy and force spectroscopy study of Langmuir-Blodgett films formed by heteroacid phospholipids of biological interest. Biochimica Et Biophysica Acta. 1768: 1190-8. PMID 17376401 DOI: 10.1016/J.Bbamem.2007.02.004 |
0.531 |
|
| 2007 |
Brujic J, Hermans RI, Garcia-Manyes S, Walther KA, Fernandez JM. Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy. Biophysical Journal. 92: 2896-903. PMID 17259284 DOI: 10.1529/Biophysj.106.099481 |
0.787 |
|
| 2006 |
Perez-Jimenez R, Garcia-Manyes S, Ainavarapu SR, Fernandez JM. Mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy. The Journal of Biological Chemistry. 281: 40010-4. PMID 17082195 DOI: 10.1074/Jbc.M609890200 |
0.791 |
|
| 2006 |
Garcia-Manyes S, Gorostiza P, Sanz F. Titration force microscopy on supported lipid bilayers. Analytical Chemistry. 78: 61-70. PMID 16383311 DOI: 10.1021/Ac0510437 |
0.487 |
|
| 2006 |
Garcia-Manyes S, Bucior I, Ros R, Anselmetti D, Sanz F, Burger MM, Fernàndez-Busquets X. Proteoglycan mechanics studied by single-molecule force spectroscopy of allotypic cell adhesion glycans. The Journal of Biological Chemistry. 281: 5992-9. PMID 16373355 DOI: 10.1074/Jbc.M507878200 |
0.403 |
|
| 2006 |
Garcia-Manyes S, Oncins G, Sanz F. Effect of pH and ionic strength on phospholipid nanomechanics and on deposition process onto hydrophilic surfaces measured by AFM Electrochimica Acta. 51: 5029-5036. DOI: 10.1016/J.Electacta.2006.03.062 |
0.371 |
|
| 2005 |
Garcia-Manyes S, Güell AG, Gorostiza P, Sanz F. Nanomechanics of silicon surfaces with atomic force microscopy: an insight to the first stages of plastic deformation. The Journal of Chemical Physics. 123: 114711. PMID 16392587 DOI: 10.1063/1.2035094 |
0.432 |
|
| 2005 |
Garcia-Manyes S, Oncins G, Sanz F. Effect of temperature on the nanomechanics of lipid bilayers studied by force spectroscopy. Biophysical Journal. 89: 4261-74. PMID 16150966 DOI: 10.1529/Biophysj.105.065581 |
0.432 |
|
| 2005 |
Oncins G, Garcia-Manyes S, Sanz F. Study of frictional properties of a phospholipid bilayer in a liquid environment with lateral force microscopy as a function of NaCl concentration. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 7373-9. PMID 16042468 DOI: 10.1021/La050644Q |
0.465 |
|
| 2005 |
Garcia-Manyes S, Oncins G, Sanz F. Effect of ion-binding and chemical phospholipid structure on the nanomechanics of lipid bilayers studied by force spectroscopy. Biophysical Journal. 89: 1812-26. PMID 15980180 DOI: 10.1529/Biophysj.105.064030 |
0.392 |
|
| 2005 |
Morant C, Garcia-Manyes S, Sanz F, Sanz JM, Elizalde E. Nanotribological properties of CN/TiCN/TiN/Si multilayer as determined by AFM Nanotechnology. 16. DOI: 10.1088/0957-4484/16/5/014 |
0.369 |
|
| 2004 |
Garcia-Manyes S, Verdaguer A, Gorostiza P, Sanz F. Alkali halide nanocrystal growth and etching studied by AFM and modeled by MD simulations. The Journal of Chemical Physics. 120: 2963-71. PMID 15268443 DOI: 10.1063/1.1628223 |
0.376 |
|
| 2002 |
Fraxedas J, Garcia-Manyes S, Gorostiza P, Sanz F. Nanoindentation: Toward the sensing of atomic interactions. Proceedings of the National Academy of Sciences of the United States of America. 99: 5228-5232. PMID 16578871 DOI: 10.1073/Pnas.042106699 |
0.344 |
|
| 2002 |
Garcia-Manyes S, Gorostiza P, Sanz F. Nanoindentation: From forces to energies Mrs Proceedings. 738: 195-200. DOI: 10.1557/Proc-738-G6.2 |
0.44 |
|
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