| Year |
Citation |
Score |
| 2024 |
Shih TM, Munoz C, Acon-Chen C, Keith ZM. Pharmacology of Adenosine A Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication. Neurotoxicity Research. 42: 41. PMID 39230655 DOI: 10.1007/s12640-024-00717-z |
0.438 |
|
| 2024 |
Keith ZM, Munoz C, Acon-Chen C, Shih TM. Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A receptor agonist as an adjunct to standard medical treatment. Toxicology and Applied Pharmacology. 116970. PMID 38777098 DOI: 10.1016/j.taap.2024.116970 |
0.397 |
|
| 2024 |
Munoz C, Acon-Chen C, Keith ZM, Shih TM. Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A Receptor Agonist and Body Cooling. Neuropharmacology. 109966. PMID 38677446 DOI: 10.1016/j.neuropharm.2024.109966 |
0.364 |
|
| 2023 |
Shih TM. A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A adenosine receptor agonist following soman intoxication. Toxicology and Applied Pharmacology. 464: 116437. PMID 36849019 DOI: 10.1016/j.taap.2023.116437 |
0.407 |
|
| 2021 |
Lumley L, Du F, Marrero-Rosado B, Stone M, Keith ZM, Schultz C, Whitten K, Walker K, Acon-Chen C, Wright L, Shih TM. Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs. Toxicology Reports. 8: 896-907. PMID 33996503 DOI: 10.1016/j.toxrep.2021.04.005 |
0.388 |
|
| 2021 |
Loughery TN, Whitten KA, Acon-Chen C, Shih TM. Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus. Toxicology and Applied Pharmacology. 419: 115515. PMID 33798593 DOI: 10.1016/j.taap.2021.115515 |
0.376 |
|
| 2021 |
Meads KL, Thomas TP, Langston JL, Myers TM, Shih TM. Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and Applied Pharmacology. 115466. PMID 33631229 DOI: 10.1016/j.taap.2021.115466 |
0.348 |
|
| 2021 |
Shih TM, Oyler BL, Capacio BR, Koplovitz I. The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs. Toxicology and Applied Pharmacology. 115443. PMID 33548273 DOI: 10.1016/j.taap.2021.115443 |
0.471 |
|
| 2020 |
Koenig JA, Acon Chen C, Shih TM. Development of a Larval Zebrafish Model for Acute Organophosphorus Nerve Agent and Pesticide Exposure and Therapeutic Evaluation. Toxics. 8. PMID 33213094 DOI: 10.3390/toxics8040106 |
0.321 |
|
| 2019 |
Thomas TP, Wegener A, Shih TM. In Vivo Evaluation of A1 Adenosine Agonists as Novel Anticonvulsant Medical Countermeasures to Nerve Agent Intoxication in a Rat Soman Seizure Model. Neurotoxicity Research. PMID 31069755 DOI: 10.1007/S12640-019-00034-W |
0.556 |
|
| 2019 |
Shih T. The Use of Adenosine Agonists to Treat Nerve Agent-Induced Seizure and Neuropathology Biomedical Journal of Scientific & Technical Research. 17. DOI: 10.26717/BJSTR.2019.17.003074 |
0.545 |
|
| 2018 |
Shih TM, Koenig JA, Acon Chen C. Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality. Toxicology Mechanisms and Methods. 1-25. PMID 30558458 DOI: 10.1080/15376516.2018.1558322 |
0.582 |
|
| 2018 |
Beste A, Taylor DE, Shih TM, Thomas TP. Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A receptor agonist N-cyclopentyladenosine. Computational Biology and Chemistry. 75: 74-81. PMID 29747078 DOI: 10.1016/J.Compbiolchem.2018.04.017 |
0.427 |
|
| 2016 |
Acon-Chen C, Koenig JA, Smith GR, Truitt AR, Thomas TP, Shih TM. Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats. Toxicology Mechanisms and Methods. 1-11. PMID 27329284 DOI: 10.1080/15376516.2016.1197992 |
0.625 |
|
| 2016 |
Koenig JA, Dao TL, Kan RK, Shih TM. Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation. Annals of the New York Academy of Sciences. PMID 27123828 DOI: 10.1111/Nyas.13051 |
0.399 |
|
| 2016 |
Cadieux CL, Wang H, Zhang Y, Koenig JA, Shih TM, McDonough J, Koh J, Cerasoli D. Probing the Activity of a Non-Oxime Reactivator for Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. Chemico-Biological Interactions. PMID 27062893 DOI: 10.1016/J.Cbi.2016.04.002 |
0.572 |
|
| 2014 |
Thomas TP, Shih TM. Stimulation of central A1 adenosine receptors suppresses seizure and neuropathology in a soman nerve agent seizure rat model. Toxicology Mechanisms and Methods. 24: 385-95. PMID 24785252 DOI: 10.3109/15376516.2014.920450 |
0.575 |
|
| 2012 |
Skovira JW, Shih TM, McDonough JH. Neuropharmacological specificity of brain structures involved in soman-induced seizures Neurotoxicology. 33: 463-468. PMID 22774227 DOI: 10.1016/J.Neuro.2012.03.006 |
0.64 |
|
| 2011 |
O'Donnell JC, McDonough JH, Shih TM. In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate. Archives of Toxicology. 85: 1607-16. PMID 21695469 DOI: 10.1007/S00204-011-0724-Z |
0.786 |
|
| 2011 |
Shih TM, Guarisco JA, Myers TM, Kan RK, McDonough JH. The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs. Toxicology Mechanisms and Methods. 21: 53-62. PMID 21117832 DOI: 10.3109/15376516.2010.529190 |
0.684 |
|
| 2010 |
O'Donnell JC, Acon-Chen C, McDonough JH, Shih TM. Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs. Toxicology Mechanisms and Methods. 20: 600-8. PMID 20919801 DOI: 10.3109/15376516.2010.521208 |
0.785 |
|
| 2010 |
McDonough JH, McMonagle JD, Shih TM. Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs. Drug and Chemical Toxicology. 33: 279-83. PMID 20429808 DOI: 10.3109/01480540903483417 |
0.616 |
|
| 2010 |
Skovira JW, O'Donnell JC, Koplovitz I, Kan RK, McDonough JH, Shih TM. Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs. Chemico-Biological Interactions. 187: 318-24. PMID 20230808 DOI: 10.1016/J.Cbi.2010.03.010 |
0.764 |
|
| 2010 |
Shih TM, Skovira JW, O'Donnell JC, McDonough JH. In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs. Chemico-Biological Interactions. 187: 207-14. PMID 20223229 DOI: 10.1016/J.Cbi.2010.03.006 |
0.772 |
|
| 2010 |
O'Donnell JC, McDonough JH, Shih TM. Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs. Toxicology Mechanisms and Methods. 20: 143-52. PMID 20163292 DOI: 10.3109/15376511003657439 |
0.788 |
|
| 2010 |
Skovira JW, McDonough JH, Shih TM. Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. Journal of Molecular Neuroscience : Mn. 40: 56-62. PMID 19690985 DOI: 10.1007/S12031-009-9253-0 |
0.589 |
|
| 2010 |
Shih TM, Skovira JW, O'Donnell JC, McDonough JH. Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication. Journal of Molecular Neuroscience : Mn. 40: 63-9. PMID 19680820 DOI: 10.1007/S12031-009-9259-7 |
0.77 |
|
| 2009 |
Shih TM, Skovira JW, O'Donnell JC, McDonough JH. Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose. Toxicology Mechanisms and Methods. 19: 386-400. PMID 19778239 DOI: 10.1080/15376510903213892 |
0.778 |
|
| 2009 |
Guarisco JA, O'Donnell JC, Skovira JW, McDonough JH, Shih TM. In vivo oxime administration does not influence Ellman acetylcholinesterase assay results. Toxicology Mechanisms and Methods. 19: 379-85. PMID 19778238 DOI: 10.1080/15376510903234773 |
0.707 |
|
| 2009 |
Shih TM, Skovira JW, McDonough JH. Effects of 4-pyridine aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea pigs. Archives of Toxicology. 83: 1083-9. PMID 19763542 DOI: 10.1007/S00204-009-0465-4 |
0.639 |
|
| 2009 |
McDonough JH, Van Shura KE, LaMont JC, McMonagle JD, Shih TM. Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures. Basic & Clinical Pharmacology & Toxicology. 104: 27-34. PMID 19053994 DOI: 10.1111/J.1742-7843.2008.00326.X |
0.591 |
|
| 2007 |
Whalley CE, McGuire JM, Miller DB, Jakubowski EM, Mioduszewski RJ, Thomson SA, Lumley LA, McDonough JH, Shih TM. Kinetics of sarin (GB) following a single sublethal inhalation exposure in the guinea pig. Inhalation Toxicology. 19: 667-81. PMID 17510839 DOI: 10.1080/08958370701353296 |
0.341 |
|
| 2007 |
Shih TM, Rowland TC, McDonough JH. Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine. The Journal of Pharmacology and Experimental Therapeutics. 320: 154-61. PMID 17015638 DOI: 10.1124/Jpet.106.111252 |
0.633 |
|
| 2006 |
Shih TM, Hulet SW, McDonough JH. The effects of repeated low-dose sarin exposure. Toxicology and Applied Pharmacology. 215: 119-34. PMID 16556454 DOI: 10.1016/J.Taap.2006.02.003 |
0.444 |
|
| 2005 |
Shih TM, Kan RK, McDonough JH. In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents. Chemico-Biological Interactions. 157: 293-303. PMID 16256093 DOI: 10.1016/J.Cbi.2005.10.042 |
0.592 |
|
| 2005 |
Scremin OU, Shih TM, Huynh L, Roch M, Sun W, Chialvo DR, Jenden DJ. Low-dose cholinesterase inhibitors do not induce delayed effects on cerebral blood flow and metabolism. Pharmacology, Biochemistry, and Behavior. 80: 529-40. PMID 15820522 DOI: 10.1016/J.Pbb.2004.12.013 |
0.302 |
|
| 2004 |
Atchison CR, Sheridan RE, Duniho SM, Shih TM. Development of a Guinea pig model for low-dose, long-term exposure to organophosphorus nerve agents. Toxicology Mechanisms and Methods. 14: 183-94. PMID 20021145 DOI: 10.1080/15376520490429166 |
0.407 |
|
| 2004 |
McDonough JH, Benjamin A, McMonagle JD, Rowland T, Shih TM. Effects of fosphenytoin on nerve agent-induced status epilepticus. Drug and Chemical Toxicology. 27: 27-39. PMID 15038246 DOI: 10.1081/Dct-120027895 |
0.577 |
|
| 2003 |
Shih TM, Duniho SM, McDonough JH. Control of nerve agent-induced seizures is critical for neuroprotection and survival. Toxicology and Applied Pharmacology. 188: 69-80. PMID 12691725 |
0.583 |
|
| 2000 |
McDonough JH, Zoeffel LD, McMonagle J, Copeland TL, Smith CD, Shih TM. Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs. Epilepsy Research. 38: 1-14. PMID 10604601 DOI: 10.1016/S0920-1211(99)00060-1 |
0.581 |
|
| 1999 |
McDonough JH, McMonagle J, Copeland T, Zoeffel D, Shih TM. Comparative evaluation of benzodiazepines for control of soman-induced seizures. Archives of Toxicology. 73: 473-8. PMID 10650919 DOI: 10.1007/S002040050637 |
0.599 |
|
| 1999 |
Shih T, McDonough JH, Koplovitz I. Anticonvulsants for soman-induced seizure activity. Journal of Biomedical Science. 6: 86-96. PMID 10087439 DOI: 10.1007/Bf02256439 |
0.584 |
|
| 1997 |
McDonough JH, Shih TM. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neuroscience and Biobehavioral Reviews. 21: 559-79. PMID 9353792 DOI: 10.1016/S0149-7634(96)00050-4 |
0.599 |
|
| 1997 |
Shih TM, McDonough JH. Neurochemical mechanisms in soman-induced seizures. Journal of Applied Toxicology : Jat. 17: 255-64. PMID 9285539 DOI: 10.1002/(Sici)1099-1263(199707)17:4<255::Aid-Jat441>3.0.Co;2-D |
0.506 |
|
| 1996 |
Lallement G, Shih TM, Pernot-Marino I, Baubichon D, Foquin A, McDonough JH. The role of nitric oxide in soman-induced seizures, neuropathology, and lethality. Pharmacology, Biochemistry, and Behavior. 54: 731-7. PMID 8853197 DOI: 10.1016/0091-3057(95)02223-6 |
0.458 |
|
| 1996 |
Shih T, McDonough J, Koplovitz I. Evaluation of Anticonvulsant Drugs for Soman-Induced Seizure Activity International Journal of Toxicology. 15: 43-60. DOI: 10.3109/10915819609048337 |
0.548 |
|
| 1995 |
McDonough JH, Shih TM. A study of the N-methyl-D-aspartate antagonistic properties of anticholinergic drugs. Pharmacology, Biochemistry, and Behavior. 51: 249-53. PMID 7667336 DOI: 10.1016/0091-3057(94)00372-P |
0.365 |
|
| 1993 |
McDonough JH, Shih TM. Pharmacological modulation of soman-induced seizures. Neuroscience and Biobehavioral Reviews. 17: 203-15. PMID 8515903 DOI: 10.1016/S0149-7634(05)80151-4 |
0.596 |
|
| 1990 |
Shih TM, Penetar DM, McDonough JH, Romano JA, King JM. Age-related differences in soman toxicity and in blood and brain regional cholinesterase activity. Brain Research Bulletin. 24: 429-36. PMID 2337822 DOI: 10.1016/0361-9230(90)90097-J |
0.369 |
|
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