Stephen J. Ralph - Publications

Affiliations: 
School of Medical Sciences Griffith University 

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ralph S, Mani S, Swargiary G, Rani M, Wasnik S, Singh SP, Devi A. Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance. Antioxidants & Redox Signaling. PMID 37470214 DOI: 10.1089/ars.2023.0379  0.338
2021 Mani S, Swargiary G, Ralph SJ. Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy. Mitochondrion. 62: 50-73. PMID 34758363 DOI: 10.1016/j.mito.2021.11.002  0.355
2021 Clark AM, Magawa C, Pliego-Zamora A, Low P, Reynolds M, Ralph SJ. Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 140: 111790. PMID 34119930 DOI: 10.1016/j.biopha.2021.111790  0.322
2019 Ralph SJ, Nozuhur S, ALHulais RA, Rodríguez-Enríquez S, Moreno-Sánchez R. Repurposing drugs as pro-oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers. Medicinal Research Reviews. PMID 31111530 DOI: 10.1002/Med.21589  0.437
2019 ALHulais RA, Ralph SJ. Cancer stem cells, stemness markers and selected drug targeting: metastatic colorectal cancer and cyclooxygenase-2/prostaglandin E2 connection to WNT as a model system Journal of Cancer Metastasis and Treatment. 2019. DOI: 10.20517/2394-4722.2018.71  0.367
2018 Pritchard R, Rodríguez-Enríquez S, Pacheco-Velázquez SC, Bortnik V, Moreno-Sánchez R, Ralph S. Celecoxib inhibits mitochondrial O consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway. Biochemical Pharmacology. PMID 29800556 DOI: 10.1016/J.Bcp.2018.05.013  0.477
2018 Ralph SJ, Nozuhur S, Moreno-Sánchez R, Rodríguez-Enríquez S, Pritchard R. NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy Journal of Cancer Metastasis and Treatment. 4: 49. DOI: 10.20517/2394-4722.2018.42  0.413
2017 Cutler SJ, Doecke JD, Ghazawi I, Yang J, Griffiths LR, Spring KJ, Ralph SJ, Mellick AS. Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3. Scientific Reports. 7: 8526. PMID 28819304 DOI: 10.1038/S41598-017-08581-Y  0.329
2015 Yu X, Scott SA, Pritchard R, Houston TA, Ralph SJ, Blanchard H. Redox state influence on human galectin-1 function. Biochimie. PMID 26116885 DOI: 10.1016/J.Biochi.2015.06.013  0.301
2015 Low P, Clark AM, Chou TC, Chang TC, Reynolds M, Ralph SJ. Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines. International Immunopharmacology. 26: 257-64. PMID 25858876 DOI: 10.1016/J.Intimp.2015.03.034  0.346
2015 Ralph SJ, Pritchard R, Rodríguez-Enríquez S, Moreno-Sánchez R, Ralph RK. Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death. Pharmaceuticals (Basel, Switzerland). 8: 62-106. PMID 25688484 DOI: 10.3390/Ph8010062  0.445
2015 Philip B, Ito K, Moreno-Sanchez R, Ralph SJ. Abstract B87: Prolyl hydroxylase and the regulation of reactive oxygen species (ROS) levels in cancer cells Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-B87  0.453
2014 Moreno-Sánchez R, Marín-Hernández A, Saavedra E, Pardo JP, Ralph SJ, Rodríguez-Enríquez S. Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism. The International Journal of Biochemistry & Cell Biology. 50: 10-23. PMID 24513530 DOI: 10.1016/J.Biocel.2014.01.025  0.406
2014 Stapelberg M, Zobalova R, Nguyen MN, Walker T, Stantic M, Goodwin J, Pasdar EA, Thai T, Prokopova K, Yan B, Hall S, de Pennington N, Thomas SR, Grant G, Stursa J, ... ... Ralph SJ, et al. Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans. Free Radical Biology & Medicine. 67: 41-50. PMID 24145120 DOI: 10.1016/J.Freeradbiomed.2013.10.003  0.443
2013 Dong LF, Jameson VJA, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, ... ... Ralph SJ, et al. Corrigendum to: "Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy" [Free Radic Biol Med. 50 (2011) 1546-1555]. Free Radical Biology & Medicine. 65: 895-896. PMID 30184722 DOI: 10.1016/J.Freeradbiomed.2013.08.164  0.334
2013 Kimura R, Senba M, Cutler SJ, Ralph SJ, Xiao G, Mori N. Human T cell leukemia virus type I tax-induced IκB-ζ modulates tax-dependent and tax-independent gene expression in T cells. Neoplasia (New York, N.Y.). 15: 1110-24. PMID 24027435 DOI: 10.1593/Neo.131140  0.362
2013 Philip B, Ito K, Moreno-Sánchez R, Ralph SJ. HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression. Carcinogenesis. 34: 1699-707. PMID 23740838 DOI: 10.1093/Carcin/Bgt209  0.418
2013 Amalraj J, Cutler SJ, Ghazawi I, Boyle GM, Ralph SJ. REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma. Molecular Cancer Therapeutics. 12: 1288-98. PMID 23598529 DOI: 10.1158/1535-7163.Mct-12-0923  0.443
2013 Moreno-Sánchez R, Hernández-Esquivel L, Rivero-Segura NA, Marín-Hernández A, Neuzil J, Ralph SJ, Rodríguez-Enríquez S. Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I. The Febs Journal. 280: 927-38. PMID 23206332 DOI: 10.1111/Febs.12086  0.349
2013 Neuzil J, Dong LF, Rohlena J, Truksa J, Ralph SJ. Classification of mitocans, anti-cancer drugs acting on mitochondria. Mitochondrion. 13: 199-208. PMID 22846431 DOI: 10.1016/J.Mito.2012.07.112  0.416
2013 Hahn T, Polanczyk MJ, Borodovsky A, Ramanathapuram LV, Akporiaye ET, Ralph SJ. Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Current Pharmaceutical Biotechnology. 14: 357-76. PMID 22201597 DOI: 10.2174/1389201011314030010  0.464
2013 Ralph SJ, Ito K, Wachter B, Onturk S, Wilmott J, Hersey P. Abstract B67: Galectin-1 expression related to hypoxia in primary human melanoma as a driver for metastatic progression. A target to promote anticancer immunotherapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-B67  0.442
2013 Ito K, Onturk S, Powell K, Philip B, Wilmott J, Scolyer R, Hersey P, Ralph SJ. Abstract B8: Galectin-1 expressed in human melanoma is bound to cancer stem cells: A driver for metastatic progression and target for antimetastatic cancer therapy Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-B8  0.464
2013 Philip B, Ito K, Moreno-Sánchez R, Ralph SJ. HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression Carcinogenesis. 34: 1699-1707. DOI: 10.1093/carcin/bgt209  0.31
2013 Ghazawi I, Mellick AS, Cutler SJ, Doecke J, Raleigh J, McArthur G, Ralph SJ. 92 : STAT5 activates the C-Myc proximal promoter: Elevated STAT5 or C-Myc expression relative to STAT1 is linked with reduced survival of melanoma patients given IFNγ therapy Cytokine. 63: 265. DOI: 10.1016/J.Cyto.2013.06.095  0.399
2013 Cutler SJ, Doecke JD, Ghazawi I, Yang J, Mellick AS, Ralph SJ. 56: STAT-1 regulates constitutive and IL-6/PMA-inducible MMP-1 and MMP-3 expression in colorectal cancer via proximal promoter STAT binding elements Cytokine. 63: 256. DOI: 10.1016/J.Cyto.2013.06.059  0.358
2013 Amalraj J, Cutler SJ, Ghazawi I, Boyle GM, Ralph SJ. 5: REST negatively and ISGF3 positively regulates the human STAT1 gene in melanoma Cytokine. 63: 244. DOI: 10.1016/J.Cyto.2013.06.008  0.445
2012 Ito K, Stannard K, Gabutero E, Clark AM, Neo SY, Onturk S, Blanchard H, Ralph SJ. Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. Cancer Metastasis Reviews. 31: 763-78. PMID 22706847 DOI: 10.1007/S10555-012-9388-2  0.392
2012 Rodríguez-Enríquez S, Hernández-Esquivel L, Marín-Hernández A, Dong LF, Akporiaye ET, Neuzil J, Ralph SJ, Moreno-Sánchez R. Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue. Biochimica Et Biophysica Acta. 1817: 1597-607. PMID 22627082 DOI: 10.1016/J.Bbabio.2012.05.005  0.38
2012 Ito K, Ralph SJ. Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence. Clinical & Experimental Metastasis. 29: 561-72. PMID 22484915 DOI: 10.1007/S10585-012-9471-7  0.396
2011 Ralph SJ, Moreno-Sánchez R, Neuzil J, Rodríguez-Enríquez S. Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death. Pharmaceutical Research. 28: 2695-730. PMID 21863476 DOI: 10.1007/S11095-011-0566-7  0.443
2011 Rohlena J, Dong LF, Ralph SJ, Neuzil J. Anticancer drugs targeting the mitochondrial electron transport chain. Antioxidants & Redox Signaling. 15: 2951-74. PMID 21777145 DOI: 10.1089/Ars.2011.3990  0.313
2011 Neuzil J, Cerny J, Dyason JC, Dong LF, Ralph SJ. Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells Molecular Nutrition and Food Research. 55: 1543-1551. PMID 21656671 DOI: 10.1002/Mnfr.201100066  0.42
2011 Ito K, Scott SA, Cutler S, Dong LF, Neuzil J, Blanchard H, Ralph SJ. Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. Angiogenesis. 14: 293-307. PMID 21523436 DOI: 10.1007/S10456-011-9213-5  0.405
2011 Zobalova R, Prokopova K, Stantic M, Stapelberg M, Dong LF, Ralph SJ, Akporiaye E, Neuzil J. The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection? Antioxidants & Redox Signaling. 15: 2989-3002. PMID 21504364 DOI: 10.1089/Ars.2010.3785  0.349
2011 Dong LF, Jameson VJ, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, ... ... Ralph SJ, et al. Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy. Free Radical Biology & Medicine. 50: 1546-55. PMID 21402148 DOI: 10.1016/J.Freeradbiomed.2011.02.032  0.454
2011 Valis K, Prochazka L, Boura E, Chladova J, Obsil T, Rohlena J, Truksa J, Dong LF, Ralph SJ, Neuzil J. Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner. Cancer Research. 71: 946-54. PMID 21245099 DOI: 10.1158/0008-5472.Can-10-2203  0.447
2011 Dong LF, Jameson VJ, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, ... ... Ralph SJ, et al. Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. The Journal of Biological Chemistry. 286: 3717-28. PMID 21059645 DOI: 10.1074/Jbc.M110.186643  0.434
2010 Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ. Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Letters. 299: 95-110. PMID 20826047 DOI: 10.1016/J.Canlet.2010.08.005  0.408
2010 Prochazka L, Dong LF, Valis K, Freeman R, Ralph SJ, Turanek J, Neuzil J. alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels. Apoptosis : An International Journal On Programmed Cell Death. 15: 782-94. PMID 20217235 DOI: 10.1007/S10495-010-0482-Z  0.409
2010 Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Saavedra E, Moreno-Sánchez R. The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Molecular Aspects of Medicine. 31: 145-70. PMID 20206201 DOI: 10.1016/J.Mam.2010.02.008  0.457
2010 Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Moreno-Sánchez R. Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Molecular Aspects of Medicine. 31: 29-59. PMID 20026172 DOI: 10.1016/J.Mam.2009.12.006  0.486
2009 Marín-Hernández A, Gallardo-Pérez JC, Ralph SJ, Rodríguez-Enríquez S, Moreno-Sánchez R. HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Reviews in Medicinal Chemistry. 9: 1084-101. PMID 19689405 DOI: 10.2174/138955709788922610  0.407
2009 Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, ... Ralph SJ, et al. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1593-600. PMID 19223492 DOI: 10.1158/1078-0432.Ccr-08-2439  0.323
2009 Ralph SJ, Neuzil J. Mitochondria as targets for cancer therapy. Molecular Nutrition & Food Research. 53: 9-28. PMID 19123183 DOI: 10.1002/Mnfr.200800044  0.45
2009 Ralph SJ, Neuzil J. Mitocans, a class of emerging anti-cancer drugs. Molecular Nutrition & Food Research. 53: 7-8. PMID 19123182 DOI: 10.1002/Mnfr.200890054  0.34
2009 Morrison BJ, Andera L, Reynolds BA, Ralph SJ, Neuzil J. Future use of mitocans against tumour-initiating cells? Molecular Nutrition & Food Research. 53: 147-53. PMID 19123176 DOI: 10.1002/Mnfr.200800254  0.37
2008 Ralph SJ. Arsenic-Based Antineoplastic Drugs and Their Mechanisms of Action Metal-Based Drugs. 2008: 260146-260146. PMID 18431449 DOI: 10.1155/2008/260146  0.428
2008 Dong LF, Low P, Dyason JC, Wang XF, Prochazka L, Witting PK, Freeman R, Swettenham E, Valis K, Liu J, Zobalova R, Turanek J, Spitz DR, Domann FE, Scheffler IE, ... Ralph SJ, et al. α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II Oncogene. 27: 4324-4335. PMID 18372923 DOI: 10.1038/Onc.2008.69  0.385
2007 Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, Stantic M, Low P, Prochazka L, Witting PK, Turanek J, Akporiaye ET, Ralph SJ, Neuzil J. Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. Cancer Research. 67: 11906-13. PMID 18089821 DOI: 10.1158/0008-5472.Can-07-3034  0.357
2007 Neuzil J, Dong LF, Ramanathapuram L, Hahn T, Chladova M, Wang XF, Zobalova R, Prochazka L, Gold M, Freeman R, Turanek J, Akporiaye ET, Dyason JC, Ralph SJ. Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. Molecular Aspects of Medicine. 28: 607-45. PMID 17499351 DOI: 10.1016/J.Mam.2007.02.003  0.451
2007 Wang XF, Birringer M, Dong LF, Veprek P, Low P, Swettenham E, Stantic M, Yuan LH, Zobalova R, Wu K, Ledvina M, Ralph SJ, Neuzil J. A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Cancer Research. 67: 3337-44. PMID 17409443 DOI: 10.1158/0008-5472.Can-06-2480  0.364
2007 Neuzil J, Stantic M, Zobalova R, Chladova J, Wang X, Prochazka L, Dong L, Andera L, Ralph SJ. Tumour-initiating cells vs. cancer 'stem' cells and CD133: what's in the name? Biochemical and Biophysical Research Communications. 355: 855-9. PMID 17307142 DOI: 10.1016/J.Bbrc.2007.01.159  0.403
2007 Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. Journal of Bioenergetics and Biomembranes. 39: 65-72. PMID 17294131 DOI: 10.1007/S10863-006-9060-Z  0.45
2007 Neuzil J, Tomasetti M, Zhao Y, Dong LF, Birringer M, Wang XF, Low P, Wu K, Salvatore BA, Ralph SJ. Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent. Molecular Pharmacology. 71: 1185-99. PMID 17220355 DOI: 10.1124/Mol.106.030122  0.405
2006 Ralph SJ, Low P, Dong L, Lawen A, Neuzil J. Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. Recent Patents On Anti-Cancer Drug Discovery. 1: 327-46. PMID 18221044 DOI: 10.2174/157489206778776952  0.474
2006 Neuzil J, Wang XF, Dong LF, Low P, Ralph SJ. Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. Febs Letters. 580: 5125-9. PMID 16979626 DOI: 10.1016/J.Febslet.2006.05.072  0.398
2005 Dezfouli S, Hatzinisiriou I, Ralph SJ. Use of cytokines in cancer vaccines/immunotherapy: recent developments improve survival rates for patients with metastatic malignancy. Current Pharmaceutical Design. 11: 3511-3530. PMID 16248805 DOI: 10.2174/138161205774414574  0.364
2005 Ghazawi I, Cutler SJ, Low P, Mellick AS, Ralph SJ. Inhibitory effects associated with use of modified Photinus pyralis and Renilla reniformis luciferase vectors in dual reporter assays and implications for analysis of ISGs. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 92-102. PMID 15695930 DOI: 10.1089/Jir.2005.25.92  0.366
2002 Wong LH, Sim H, Chatterjee-Kishore M, Hatzinisiriou I, Devenish RJ, Stark G, Ralph SJ. Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1 Journal of Biological Chemistry. 277: 19408-19417. PMID 11909852 DOI: 10.1074/Jbc.M111302200  0.641
1997 Wong LH, Krauer KG, Hatzinisiriou I, Estcourt MJ, Hersey P, Tam ND, Edmondson S, Devenish RJ, Ralph SJ. Interferon-resistant Human Melanoma Cells Are Deficient in ISGF3 Components, STAT1, STAT2, and p48-ISGF3γ Journal of Biological Chemistry. 272: 28779-28785. PMID 9353349 DOI: 10.1074/Jbc.272.45.28779  0.63
1991 Lock P, Ralph S, Stanley E, Boulet I, Ramsay R, Dunn AR. Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. Molecular and Cellular Biology. 11: 4363-70. PMID 1875927 DOI: 10.1128/Mcb.11.9.4363  0.317
1991 Stanley E, Ralph S, McEwen S, Boulet I, Holtzman DA, Lock P, Dunn AR. Alternatively spliced murine lyn mRNAs encode distinct proteins. Molecular and Cellular Biology. 11: 3399-406. PMID 1710766 DOI: 10.1128/Mcb.11.7.3399  0.307
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