| Year |
Citation |
Score |
| 2022 |
Zieliński M, Blanchet J, Hailemariam S, Berghuis AM. Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa. Plos One. 17: e0269684. PMID 35921328 DOI: 10.1371/journal.pone.0269684 |
0.521 |
|
| 2021 |
Golkar T, Bassenden AV, Maiti K, Arya DP, Schmeing TM, Berghuis AM. Structural basis for plazomicin antibiotic action and resistance. Communications Biology. 4: 729. PMID 34117352 DOI: 10.1038/s42003-021-02261-4 |
0.47 |
|
| 2021 |
Bassenden AV, Dumalo L, Park J, Blanchet J, Maiti K, Arya DP, Berghuis AM. Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes. Scientific Reports. 11: 11614. PMID 34078922 DOI: 10.1038/s41598-021-89446-3 |
0.509 |
|
| 2021 |
Zieliński M, Park J, Sleno B, Berghuis AM. Structural and functional insights into esterase-mediated macrolide resistance. Nature Communications. 12: 1732. PMID 33741980 DOI: 10.1038/s41467-021-22016-3 |
0.496 |
|
| 2020 |
Park J, Pandya VR, Ezekiel SJ, Berghuis AM. Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective. Frontiers in Chemistry. 8: 612728. PMID 33490038 DOI: 10.3389/fchem.2020.612728 |
0.372 |
|
| 2020 |
Bassenden AV, Park J, Rodionov D, Berghuis AM. Revisiting the Catalytic Cycle and Kinetic Mechanism of ANT(2″): A Structural and Kinetic Study. Acs Chemical Biology. PMID 32100995 DOI: 10.1021/acschembio.9b00904 |
0.426 |
|
| 2019 |
Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN. Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. Acs Omega. 4: 10056-10069. PMID 31460098 DOI: 10.1021/acsomega.9b00640 |
0.459 |
|
| 2018 |
Golkar T, Zieliński M, Berghuis AM. Look and Outlook on Enzyme-Mediated Macrolide Resistance. Frontiers in Microbiology. 9: 1942. PMID 30177927 DOI: 10.3389/fmicb.2018.01942 |
0.466 |
|
| 2018 |
Caldwell SJ, Berghuis AM. Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia. Antimicrobial Agents and Chemotherapy. PMID 29661878 DOI: 10.1128/Aac.00202-18 |
0.719 |
|
| 2017 |
Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. Plos One. 12: e0186447. PMID 29036218 DOI: 10.1371/Journal.Pone.0186447 |
0.302 |
|
| 2017 |
Bacot-Davis VR, Bassenden AV, Sprules T, Berghuis AM. Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia. Protein Science : a Publication of the Protein Society. PMID 28734024 DOI: 10.1002/pro.3224 |
0.491 |
|
| 2017 |
Fong DH, Burk DL, Blanchet J, Yan AY, Berghuis AM. Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure (London, England : 1993). PMID 28416110 DOI: 10.1016/J.Str.2017.03.007 |
0.585 |
|
| 2017 |
Park J, Zielinski M, Magder A, Tsantrizos YS, Berghuis AM. Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nature Communications. 8: 14132. PMID 28098152 DOI: 10.1038/ncomms14132 |
0.414 |
|
| 2016 |
Baettig OM, Shi K, Yachnin BJ, Burk DL, Berghuis AM. Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme. The Febs Journal. PMID 27333541 DOI: 10.1111/Febs.13788 |
0.489 |
|
| 2016 |
Caldwell SJ, Huang Y, Berghuis AM. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia. Structure (London, England : 1993). PMID 27161980 DOI: 10.1016/J.Str.2016.04.002 |
0.725 |
|
| 2016 |
Bassenden AV, Rodionov D, Shi K, Berghuis AM. Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design. Acs Chemical Biology. PMID 26900880 DOI: 10.1021/acschembio.5b01070 |
0.519 |
|
| 2015 |
Brannon JR, Burk DL, Leclerc JM, Thomassin JL, Portt A, Berghuis AM, Gruenheid S, Le Moual H. Inhibition of outer membrane proteases of the omptin family by aprotinin. Infection and Immunity. 83: 2300-11. PMID 25824836 DOI: 10.1128/Iai.00136-15 |
0.322 |
|
| 2015 |
Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 25: 1117-23. PMID 25630225 DOI: 10.1016/J.Bmcl.2014.12.089 |
0.359 |
|
| 2014 |
Yachnin BJ, McEvoy MB, MacCuish RJ, Morley KL, Lau PC, Berghuis AM. Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis. Acs Chemical Biology. 9: 2843-51. PMID 25265531 DOI: 10.1021/cb500442e |
0.42 |
|
| 2014 |
Freiburger L, Miletti T, Zhu S, Baettig O, Berghuis A, Auclair K, Mittermaier A. Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. Nature Chemical Biology. 10: 937-42. PMID 25218742 DOI: 10.1038/Nchembio.1626 |
0.483 |
|
| 2014 |
Park J, Lin YS, Tsantrizos YS, Berghuis AM. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica. Section F, Structural Biology Communications. 70: 299-304. PMID 24598914 DOI: 10.1107/S2053230X14002106 |
0.447 |
|
| 2014 |
Yachnin B, McEvoy M, MacCuish R, Morley K, Mittermaier A, Lau P, Berghuis A. The Structural Basis for BVMO Substrate Profile and Stereospecificity Acta Crystallographica Section a Foundations and Advances. 70: C485-C485. DOI: 10.1107/S205327331409514X |
0.532 |
|
| 2014 |
Bassenden A, Rodionov D, Sabet-Kassouf N, Haji T, Shi K, Berghuis A. "Structural characterization of aminoglycoside modifying enzyme ANT(2"")-Ia" Acta Crystallographica Section a Foundations and Advances. 70: C702-C702. DOI: 10.1107/S2053273314092973 |
0.558 |
|
| 2014 |
Blanchet J, Fong D, Berghuis A. Study of 2'-macrolide phosphotransferase selectivity for different substrates Acta Crystallographica Section a Foundations and Advances. 70: C703-C703. DOI: 10.1107/S2053273314092961 |
0.551 |
|
| 2014 |
Caldwell S, Berghuis A. A catalytic switch uncovered in gentamicin resistance kinase APH(2'')-Ia Acta Crystallographica Section a Foundations and Advances. 70: C704-C704. DOI: 10.1107/S205327331409295X |
0.732 |
|
| 2014 |
Fong D, Blanchet J, Berghuis A. Determinants of nucleoside specificity of a macrolide phosphotransferase Acta Crystallographica Section a Foundations and Advances. 70: C705-C705. DOI: 10.1107/S2053273314092948 |
0.556 |
|
| 2014 |
Park J, Leung C, Lin Y, De Schutter J, Tsantrizos Y, Berghuis A. Crystal structures of hFPPS in complex with novel anticancer drug leads Acta Crystallographica Section a Foundations and Advances. 70: C712-C712. DOI: 10.1107/S2053273314092870 |
0.435 |
|
| 2014 |
Rodionov D, Marks D, Romero P, Berghuis A. Crystal structure of an alleged mannosylphosphate transferase Ktr6p at 3.06 Å Acta Crystallographica Section a Foundations and Advances. 70: C1671-C1671. DOI: 10.1107/S2053273314083284 |
0.439 |
|
| 2013 |
Shi K, Caldwell SJ, Fong DH, Berghuis AM. Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance. Frontiers in Cellular and Infection Microbiology. 3: 22. PMID 23805415 DOI: 10.3389/Fcimb.2013.00022 |
0.7 |
|
| 2013 |
Mirza IA, Burk DL, Xiong B, Iwaki H, Hasegawa Y, Grosse S, Lau PC, Berghuis AM. Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A. Plos One. 8: e60072. PMID 23555888 DOI: 10.1371/Journal.Pone.0060072 |
0.441 |
|
| 2012 |
Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Structural Biology. 12: 32. PMID 23234314 DOI: 10.1186/1472-6807-12-32 |
0.45 |
|
| 2012 |
Yachnin BJ, Sprules T, McEvoy MB, Lau PC, Berghuis AM. The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation. Journal of the American Chemical Society. 134: 7788-95. PMID 22506764 DOI: 10.1021/ja211876p |
0.431 |
|
| 2012 |
Shi K, Berghuis AM. Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases. The Journal of Biological Chemistry. 287: 13094-102. PMID 22371504 DOI: 10.1074/jbc.M112.349670 |
0.568 |
|
| 2012 |
Caldwell SJ, Berghuis AM. Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure. Antimicrobial Agents and Chemotherapy. 56: 1899-906. PMID 22290965 DOI: 10.1128/Aac.06378-11 |
0.722 |
|
| 2011 |
Yachnin BJ, Colin DY, Volpato JP, Ebert M, Pelletier JN, Berghuis AM. Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67: 1316-1322. PMID 22102224 DOI: 10.1107/S1744309111030417 |
0.349 |
|
| 2011 |
Shi K, Houston DR, Berghuis AM. Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases. Biochemistry. 50: 6237-44. PMID 21678960 DOI: 10.1021/bi200747f |
0.606 |
|
| 2011 |
Fong DH, Xiong B, Hwang J, Berghuis AM. Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. Plos One. 6: e19589. PMID 21573013 DOI: 10.1371/journal.pone.0019589 |
0.435 |
|
| 2011 |
Freiburger LA, Baettig OM, Sprules T, Berghuis AM, Auclair K, Mittermaier AK. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme. Nature Structural & Molecular Biology. 18: 288-94. PMID 21278754 DOI: 10.1038/Nsmb.1978 |
0.424 |
|
| 2011 |
Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, Li S, Berghuis AM, Branton PE. Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein. Journal of Virology. 85: 286-95. PMID 21047956 DOI: 10.1128/Jvi.01381-10 |
0.303 |
|
| 2010 |
Fong DH, Lemke CT, Hwang J, Xiong B, Berghuis AM. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. The Journal of Biological Chemistry. 285: 9545-55. PMID 20089863 DOI: 10.1074/jbc.M109.038364 |
0.599 |
|
| 2009 |
Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance Journal of Biological Chemistry. 284: 20079-20089. PMID 19478082 DOI: 10.1074/Jbc.M109.018010 |
0.512 |
|
| 2009 |
Fong DH, Berghuis AM. Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics. Antimicrobial Agents and Chemotherapy. 53: 3049-55. PMID 19433564 DOI: 10.1128/AAC.00062-09 |
0.556 |
|
| 2009 |
Mirza IA, Yachnin BJ, Wang S, Grosse S, Bergeron H, Imura A, Iwaki H, Hasegawa Y, Lau PC, Berghuis AM. Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor. Journal of the American Chemical Society. 131: 8848-54. PMID 19385644 DOI: 10.1021/ja9010578 |
0.35 |
|
| 2007 |
Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K. Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Molecular Cell. 27: 474-85. PMID 17679095 DOI: 10.1016/J.Molcel.2007.06.023 |
0.311 |
|
| 2007 |
Korczynska M, Mukhtar TA, Wright GD, Berghuis AM. Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase. Proceedings of the National Academy of Sciences of the United States of America. 104: 10388-93. PMID 17563376 DOI: 10.1073/Pnas.0701809104 |
0.478 |
|
| 2006 |
Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, Wright GD, Auclair K. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. Journal of Medicinal Chemistry. 49: 5273-81. PMID 16913716 DOI: 10.1021/Jm060732N |
0.438 |
|
| 2006 |
Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM. Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity. The Journal of Biological Chemistry. 281: 24489-95. PMID 16651261 DOI: 10.1074/Jbc.M602393200 |
0.453 |
|
| 2006 |
Fong DH, Yim VCN, D'Elia MA, Brown ED, Berghuis AM. Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism Biochimica Et Biophysica Acta - Proteins and Proteomics. 1764: 63-69. PMID 16344011 DOI: 10.1016/j.bbapap.2005.10.015 |
0.402 |
|
| 2005 |
Lemke CT, Hwang J, Xiong B, Cianciotto NP, Berghuis AM. Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 606-8. PMID 16511108 DOI: 10.1107/S1744309105016301 |
0.382 |
|
| 2005 |
Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM. Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of α/β-hydrolases Biochemistry. 44: 15768-15773. PMID 16313180 DOI: 10.1021/Bi051951Y |
0.415 |
|
| 2005 |
Demendi M, Ishiyama N, Lam JS, Berghuis AM, Creuzenet C. Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP Biochemical Journal. 389: 173-180. PMID 15752069 DOI: 10.1042/BJ20050263 |
0.408 |
|
| 2005 |
Ishiyama N, Demendi M, Creuzenet C, Lam JS, Berghuis A. Structural studies of FlaA1, a UDP-GlcNAc 4,6-dehydratase Acta Crystallographica Section a Foundations of Crystallography. 61: c189-c189. DOI: 10.1107/S0108767305091968 |
0.362 |
|
| 2004 |
Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD. New phenolic inhibitors of yeast homoserine dehydrogenase. Bioorganic & Medicinal Chemistry. 12: 3825-30. PMID 15210149 DOI: 10.1016/J.Bmc.2004.05.009 |
0.352 |
|
| 2004 |
Ishiyama N, Creuzenet C, Lam JS, Berghuis AM. Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: Substrate specificity in UDP-hexose 4-epimerases Journal of Biological Chemistry. 279: 22635-22642. PMID 15016816 DOI: 10.1074/jbc.M401642200 |
0.408 |
|
| 2003 |
Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD. Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Chemistry & Biology. 10: 989-95. PMID 14583265 DOI: 10.1016/J.Chembiol.2003.09.015 |
0.395 |
|
| 2003 |
Burk DL, Ghuman N, Wybenga-Groot LE, Berghuis AM. X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members. Protein Science : a Publication of the Protein Society. 12: 426-37. PMID 12592013 DOI: 10.1110/Ps.0233503 |
0.475 |
|
| 2002 |
Burk DL, Berghuis AM. Protein kinase inhibitors and antibiotic resistance. Pharmacology & Therapeutics. 93: 283-92. PMID 12191620 DOI: 10.1016/S0163-7258(02)00197-3 |
0.568 |
|
| 2002 |
Thompson PR, Boehr DD, Berghuis AM, Wright GD. Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry. 41: 7001-7. PMID 12033933 DOI: 10.1021/Bi0256680 |
0.443 |
|
| 2002 |
Fong DH, Berghuis AM. Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry Embo Journal. 21: 2323-2331. PMID 12006485 DOI: 10.1093/emboj/21.10.2323 |
0.558 |
|
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