| Year |
Citation |
Score |
| 2024 |
Göse M, Magill EE, Hughes-Games A, Shaw SJ, Diffin FM, Rawson T, Nagy Z, Seidel R, Szczelkun MD. Short-range translocation by a restriction enzyme motor triggers diffusion along DNA. Nature Chemical Biology. PMID 38167920 DOI: 10.1038/s41589-023-01504-1 |
0.67 |
|
| 2022 |
Naqvi MM, Lee L, Montaguth OET, Diffin FM, Szczelkun MD. CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage. Nature Chemical Biology. PMID 35836018 DOI: 10.1038/s41589-022-01082-8 |
0.499 |
|
| 2021 |
Torres Montaguth OE, Cross SJ, Ingram KWA, Lee L, Diffin FM, Szczelkun MD. ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing. Nucleic Acids Research. PMID 34417616 DOI: 10.1093/nar/gkab727 |
0.535 |
|
| 2020 |
Mullally G, van Aelst K, Naqvi MM, Diffin FM, Karvelis T, Gasiunas G, Siksnys V, Szczelkun MD. 5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage. Nucleic Acids Research. 48: 6811-6823. PMID 32496535 DOI: 10.1093/nar/gkaa477 |
0.347 |
|
| 2019 |
van Aelst K, Martínez-Santiago CJ, Cross SJ, Szczelkun MD. The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a. Genes. 10. PMID 30813348 DOI: 10.3390/genes10020169 |
0.543 |
|
| 2018 |
Nirwan N, Singh P, Mishra GG, Johnson CM, Szczelkun MD, Inoue K, Vinothkumar KR, Saikrishnan K. Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity. Nucleic Acids Research. PMID 30521042 DOI: 10.1093/Nar/Gky1170 |
0.353 |
|
| 2017 |
Toliusis P, Zaremba M, Silanskas A, Szczelkun MD, Siksnys V. CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases. Nucleic Acids Research. 45: 8435-8447. PMID 28854738 DOI: 10.1093/nar/gkx580 |
0.644 |
|
| 2016 |
Kulkarni M, Nirwan N, van Aelst K, Szczelkun MD, Saikrishnan K. Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes. Nucleic Acids Research. 44: 4396-408. PMID 26975655 DOI: 10.1093/nar/gkw154 |
0.34 |
|
| 2015 |
Tóth J, Bollins J, Szczelkun MD. Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes. Nucleic Acids Research. 43: 10870-81. PMID 26538601 DOI: 10.1093/nar/gkv1154 |
0.666 |
|
| 2015 |
van Aelst K, Saikrishnan K, Szczelkun MD. Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations. Nucleic Acids Research. 43: 10430-43. PMID 26507855 DOI: 10.1093/nar/gkv1129 |
0.624 |
|
| 2015 |
Chand MK, Nirwan N, Diffin FM, van Aelst K, Kulkarni M, Pernstich C, Szczelkun MD, Saikrishnan K. Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes. Nature Chemical Biology. PMID 26389736 DOI: 10.1038/nchembio.1926 |
0.631 |
|
| 2014 |
Zaremba M, Toliusis P, Grigaitis R, Manakova E, Silanskas A, Tamulaitiene G, Szczelkun MD, Siksnys V. DNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis. Nucleic Acids Research. 42: 13887-96. PMID 25429977 DOI: 10.1093/nar/gku1236 |
0.33 |
|
| 2014 |
Simons M, Diffin FM, Szczelkun MD. ClpXP protease targets long-lived DNA translocation states of a helicase-like motor to cause restriction alleviation Nucleic Acids Research. 42: 12082-12091. PMID 25260590 DOI: 10.1093/nar/gku851 |
0.571 |
|
| 2014 |
Szczelkun MD, Tikhomirova MS, Sinkunas T, Gasiunas G, Karvelis T, Pschera P, Siksnys V, Seidel R. Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes. Proceedings of the National Academy of Sciences of the United States of America. 111: 9798-803. PMID 24912165 DOI: 10.1073/pnas.1402597111 |
0.333 |
|
| 2014 |
Butterer A, Pernstich C, Smith RM, Sobott F, Szczelkun MD, Tóth J. Type III restriction endonucleases are heterotrimeric: comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA. Nucleic Acids Research. 42: 5139-50. PMID 24510100 DOI: 10.1093/nar/gku122 |
0.583 |
|
| 2013 |
Schwarz FW, Tóth J, van Aelst K, Cui G, Clausing S, Szczelkun MD, Seidel R. The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA. Science (New York, N.Y.). 340: 353-6. PMID 23599494 DOI: 10.1126/science.1231122 |
0.608 |
|
| 2013 |
Šišáková E, van Aelst K, Diffin FM, Szczelkun MD. The Type ISP Restriction-Modification enzymes LlaBIII and LlaGI use a translocation-collision mechanism to cleave non-specific DNA distant from their recognition sites. Nucleic Acids Research. 41: 1071-80. PMID 23222132 DOI: 10.1093/nar/gks1209 |
0.614 |
|
| 2013 |
van Aelst K, Šišáková E, Szczelkun MD. DNA cleavage by Type ISP Restriction-Modification enzymes is initially targeted to the 3'-5' strand. Nucleic Acids Research. 41: 1081-90. PMID 23221632 DOI: 10.1093/nar/gks1210 |
0.636 |
|
| 2012 |
Szczelkun MD, Dillingham MS. How to build a DNA unwinding machine. Structure (London, England : 1993). 20: 1127-8. PMID 22770366 DOI: 10.1016/j.str.2012.06.006 |
0.51 |
|
| 2012 |
Tóth J, van Aelst K, Salmons H, Szczelkun MD. Dissociation from DNA of Type III Restriction-Modification enzymes during helicase-dependent motion and following endonuclease activity. Nucleic Acids Research. 40: 6752-64. PMID 22523084 DOI: 10.1093/nar/gks328 |
0.71 |
|
| 2011 |
Schwarz FW, van Aelst K, Tóth J, Seidel R, Szczelkun MD. DNA cleavage site selection by Type III restriction enzymes provides evidence for head-on protein collisions following 1D bidirectional motion. Nucleic Acids Research. 39: 8042-51. PMID 21724613 DOI: 10.1093/nar/gkr502 |
0.61 |
|
| 2011 |
Simons M, Szczelkun MD. Recycling of protein subunits during DNA translocation and cleavage by Type I restriction-modification enzymes. Nucleic Acids Research. 39: 7656-66. PMID 21712244 DOI: 10.1093/nar/gkr479 |
0.644 |
|
| 2011 |
Szczelkun MD. Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases. Biochemical Society Transactions. 39: 589-94. PMID 21428945 DOI: 10.1042/BST0390589 |
0.6 |
|
| 2010 |
Graham JE, Sherratt DJ, Szczelkun MD. Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA Proceedings of the National Academy of Sciences of the United States of America. 107: 20263-20268. PMID 21048089 DOI: 10.1073/pnas.1007518107 |
0.44 |
|
| 2010 |
van Aelst K, Tóth J, Ramanathan SP, Schwarz FW, Seidel R, Szczelkun MD. Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat. Proceedings of the National Academy of Sciences of the United States of America. 107: 9123-8. PMID 20435912 DOI: 10.1073/pnas.1001637107 |
0.632 |
|
| 2010 |
Szczelkun MD, Friedhoff P, Seidel R. Maintaining a sense of direction during long-range communication on DNA. Biochemical Society Transactions. 38: 404-9. PMID 20298192 DOI: 10.1042/BST0380404 |
0.598 |
|
| 2009 |
Smith RM, Diffin FM, Savery NJ, Josephsen J, Szczelkun MD. DNA cleavage and methylation specificity of the single polypeptide restriction-modification enzyme LlaGI. Nucleic Acids Research. 37: 7206-18. PMID 19808936 DOI: 10.1093/nar/gkp790 |
0.582 |
|
| 2009 |
Smith RM, Josephsen J, Szczelkun MD. An Mrr-family nuclease motif in the single polypeptide restriction-modification enzyme LlaGI. Nucleic Acids Research. 37: 7231-8. PMID 19793866 DOI: 10.1093/nar/gkp795 |
0.565 |
|
| 2009 |
Smith RM, Josephsen J, Szczelkun MD. The single polypeptide restriction-modification enzyme LlaGI is a self-contained molecular motor that translocates DNA loops. Nucleic Acids Research. 37: 7219-30. PMID 19783815 DOI: 10.1093/nar/gkp794 |
0.537 |
|
| 2009 |
Peakman LJ, Szczelkun MD. S-adenosyl homocysteine and DNA ends stimulate promiscuous nuclease activities in the Type III restriction endonuclease EcoPI. Nucleic Acids Research. 37: 3934-45. PMID 19401438 DOI: 10.1093/nar/gkp267 |
0.583 |
|
| 2009 |
Ramanathan SP, van Aelst K, Sears A, Peakman LJ, Diffin FM, Szczelkun MD, Seidel R. Type III restriction enzymes communicate in 1D without looping between their target sites. Proceedings of the National Academy of Sciences of the United States of America. 106: 1748-53. PMID 19181848 DOI: 10.1073/pnas.0807193106 |
0.518 |
|
| 2009 |
Schwarz FW, Ramanathan SP, van Aelst K, Szczelkun MD, Seidel R. Single-Molecule Studies Of ATP-Dependent Restriction Enzymes Biophysical Journal. 96: 415a-416a. DOI: 10.1016/J.BPJ.2008.12.2123 |
0.344 |
|
| 2008 |
Sisáková E, Weiserová M, Dekker C, Seidel R, Szczelkun MD. The interrelationship of helicase and nuclease domains during DNA translocation by the molecular motor EcoR124I. Journal of Molecular Biology. 384: 1273-86. PMID 18952104 DOI: 10.1016/J.Jmb.2008.10.017 |
0.527 |
|
| 2008 |
Sisáková E, Stanley LK, Weiserová M, Szczelkun MD. A RecB-family nuclease motif in the Type I restriction endonuclease EcoR124I. Nucleic Acids Research. 36: 3939-49. PMID 18511464 DOI: 10.1093/nar/gkn333 |
0.514 |
|
| 2008 |
Seidel R, Bloom JG, Dekker C, Szczelkun MD. Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I. The Embo Journal. 27: 1388-98. PMID 18388857 DOI: 10.1038/Emboj.2008.69 |
0.399 |
|
| 2007 |
Smith AJ, Szczelkun MD, Savery NJ. Controlling the motor activity of a transcription-repair coupling factor: autoinhibition and the role of RNA polymerase. Nucleic Acids Research. 35: 1802-11. PMID 17329375 DOI: 10.1093/nar/gkm019 |
0.32 |
|
| 2006 |
Stanley LK, Szczelkun MD. Direct and random routing of a molecular motor protein at a DNA junction. Nucleic Acids Research. 34: 4387-94. PMID 16936313 DOI: 10.1093/nar/gkl569 |
0.438 |
|
| 2006 |
Stanley LK, Seidel R, van der Scheer C, Dekker NH, Szczelkun MD, Dekker C. When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I. The Embo Journal. 25: 2230-9. PMID 16642041 DOI: 10.1038/Sj.Emboj.7601104 |
0.583 |
|
| 2006 |
Antognozzi M, Wotherspoon A, Hayes JM, Miles MJ, Szczelkun MD, Valdrè G. A chlorite mineral surface actively drives the deposition of DNA molecules in stretched conformations Nanotechnology. 17: 3897-3902. DOI: 10.1088/0957-4484/17/15/047 |
0.517 |
|
| 2005 |
Seidel R, Bloom JG, van Noort J, Dutta CF, Dekker NH, Firman K, Szczelkun MD, Dekker C. Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I. The Embo Journal. 24: 4188-97. PMID 16292342 DOI: 10.1038/Sj.Emboj.7600881 |
0.459 |
|
| 2005 |
Sears A, Szczelkun MD. Subunit assembly modulates the activities of the Type III restriction-modification enzyme PstII in vitro Nucleic Acids Research. 33: 4788-4796. PMID 16120968 DOI: 10.1093/nar/gki788 |
0.478 |
|
| 2005 |
Sears A, Peakman LJ, Wilson GG, Szczelkun MD. Characterization of the Type III restriction endonuclease PstII from Providencia stuartii. Nucleic Acids Research. 33: 4775-87. PMID 16120967 DOI: 10.1093/nar/gki787 |
0.528 |
|
| 2004 |
Peakman LJ, Szczelkun MD. DNA communications by Type III restriction endonucleases--confirmation of 1D translocation over 3D looping. Nucleic Acids Research. 32: 4166-74. PMID 15302916 DOI: 10.1093/nar/gkh762 |
0.589 |
|
| 2004 |
Halford SE, Welsh AJ, Szczelkun MD. Enzyme-mediated DNA looping Annual Review of Biophysics and Biomolecular Structure. 33: 1-24. PMID 15139802 DOI: 10.1146/Annurev.Biophys.33.110502.132711 |
0.624 |
|
| 2003 |
Peakman LJ, Antognozzi M, Bickle TA, Janscak P, Szczelkun MD. S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme. Journal of Molecular Biology. 333: 321-35. PMID 14529619 DOI: 10.1016/J.Jmb.2003.08.042 |
0.57 |
|
| 2003 |
Whitehouse I, Stockdale C, Flaus A, Szczelkun MD, Owen-Hughes T. Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme. Molecular and Cellular Biology. 23: 1935-45. PMID 12612068 DOI: 10.1128/MCB.23.6.1935-1945.2003 |
0.601 |
|
| 2003 |
Szczelkun MD. How to proteins move along DNA? Lessons from type-I and type-III restriction endonucleases. Essays in Biochemistry. 35: 131-43. PMID 12471895 DOI: 10.1042/BSE0350131 |
0.688 |
|
| 2002 |
Halford SE, Szczelkun MD. How to get from A to B: Strategies for analysing protein motion on DNA European Biophysics Journal. 31: 257-267. PMID 12122472 DOI: 10.1007/S00249-002-0224-4 |
0.535 |
|
| 2002 |
Szczelkun MD. Kinetic models of translocation, head-on collision, and DNA cleavage by type I restriction endonucleases. Biochemistry. 41: 2067-74. PMID 11827554 DOI: 10.1021/bi011824b |
0.635 |
|
| 2002 |
Antognozzi M, Szczelkun MD, Round AN, Miles MJ. Comparison Between Shear Force and Tapping Mode AFM - High Resolution Imaging of DNA Single Molecules. 3: 105-110. DOI: 10.1002/1438-5171(200206)3:2/3<105::Aid-Simo105>3.0.Co;2-# |
0.367 |
|
| 2001 |
Milsom SE, Halford SE, Embleton ML, Szczelkun MD. Analysis of DNA looping interactions by type II restriction enzymes that require two copies of their recognition sites Journal of Molecular Biology. 311: 515-527. PMID 11493005 DOI: 10.1006/Jmbi.2001.4893 |
0.592 |
|
| 2001 |
Janscak P, Sandmeier U, Szczelkun MD, Bickle TA. Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I. Journal of Molecular Biology. 306: 417-431. PMID 11178902 DOI: 10.1006/Jmbi.2000.4411 |
0.662 |
|
| 2000 |
Stanford NP, Szczelkun MD, Marko JF, Halford SE. One- and three-dimensional pathways for proteins to reach specific DNA sites Embo Journal. 19: 6546-6557. PMID 11101527 DOI: 10.1093/Emboj/19.23.6546 |
0.489 |
|
| 2000 |
Firman K, Szczelkun MD. Measuring motion on DNA by the type I restriction endonuclease EcoR124I using triplex displacement. The Embo Journal. 19: 2094-102. PMID 10790375 DOI: 10.1093/emboj/19.9.2094 |
0.681 |
|
| 1998 |
Nobbs TJ, Szczelkun MD, Wentzell LM, Halford SE. DNA excision by the SfiI restriction endonuclease Journal of Molecular Biology. 281: 419-432. PMID 9698558 DOI: 10.1006/Jmbi.1998.1966 |
0.506 |
|
| 1997 |
Szczelkun MD, Janscak P, Firman K, Halford SE. Selection of non-specific DNA cleavage sites by the type IC restriction endonuclease EcoR124I Journal of Molecular Biology. 271: 112-123. PMID 9300058 DOI: 10.1006/Jmbi.1997.1172 |
0.612 |
|
| 1997 |
Sessions RB, Oram M, Szczelkun MD, Halford SE. Random walk models for DNA synapsis by resolvase. Journal of Molecular Biology. 270: 413-25. PMID 9237907 DOI: 10.1006/Jmbi.1997.1108 |
0.487 |
|
| 1996 |
Szczelkun MD, Dillingham MS, Janscak P, Firman K, Halford SE. Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates The Embo Journal. 15: 6335-6347. DOI: 10.1002/J.1460-2075.1996.Tb01023.X |
0.6 |
|
| 1996 |
Szczelkun MD, Halford S. Recombination by resolvase to analyse DNA communications by the SfiI restriction endonuclease. The Embo Journal. 15: 1460-1469. DOI: 10.1002/J.1460-2075.1996.Tb00488.X |
0.554 |
|
| 1995 |
Vipond IB, Baldwin GS, Oram M, Erskine SG, Wentzell LM, Szczelkun MD, Nobbs TJ, Halford SE. A general assay for restriction endonucleases and other DNA-modifying enzymes with plasmid substrates. Molecular Biotechnology. 4: 259-68. PMID 8680932 DOI: 10.1007/Bf02779019 |
0.646 |
|
| 1995 |
Oram M, Szczelkun MD, Halford SE. Recombination. Pieces of the site-specific recombination puzzle. Current Biology : Cb. 5: 1106-9. PMID 8548278 DOI: 10.1016/S0960-9822(95)00222-3 |
0.548 |
|
| 1995 |
Szczelkun MD, Jones H, Connolly BA. Probing the protein - DNA interface of the EcoRV modification methyltransferase bound to its recognition sequence, GATATC Biochemistry. 34: 10734-10743. PMID 7662657 DOI: 10.1021/BI00034A005 |
0.597 |
|
| 1995 |
Szczelkun MD, Connolly BA. Sequence-specific binding of DNA by the EcoRV restriction and modification enzymes with nucleic acid and cofactor analogues Biochemistry. 34: 10724-10733. PMID 7662656 DOI: 10.1021/BI00034A004 |
0.541 |
|
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