| Year |
Citation |
Score |
| 2024 |
Isik E, Shukla K, Pospisilova M, König C, Andrs M, Rao S, Rosano V, Dobrovolna J, Krejci L, Janscak P. MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops. Science Advances. 10: eadk2685. PMID 38324687 DOI: 10.1126/sciadv.adk2685 |
0.705 |
|
| 2023 |
Martinikova AS, Stoyanov M, Oravetzova A, Kok YP, Yu S, Dobrovolna J, Janscak P, van Vugt M, Macurek L. PPM1D activity promotes the replication stress caused by cyclin E1 overexpression. Molecular Oncology. PMID 37067201 DOI: 10.1002/1878-0261.13433 |
0.327 |
|
| 2023 |
Andrs M, Stoy H, Boleslavska B, Chappidi N, Kanagaraj R, Nascakova Z, Menon S, Rao S, Oravetzova A, Dobrovolna J, Surendranath K, Lopes M, Janscak P. Excessive reactive oxygen species induce transcription-dependent replication stress. Nature Communications. 14: 1791. PMID 36997515 DOI: 10.1038/s41467-023-37341-y |
0.667 |
|
| 2022 |
Boleslavska B, Oravetzova A, Shukla K, Nascakova Z, Ibini ON, Hasanova Z, Andrs M, Kanagaraj R, Dobrovolna J, Janscak P. DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic Acids Research. 50: 12274-12290. PMID 36453994 DOI: 10.1093/nar/gkac1116 |
0.409 |
|
| 2022 |
Larsen BD, Benada J, Yung PYK, Bell RAV, Pappas G, Urban V, Ahlskog JK, Kuo TT, Janscak P, Megeney LA, Elsässer SJ, Bartek J, Sørensen CS. Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress. Science (New York, N.Y.). 376: 476-483. PMID 35482866 DOI: 10.1126/science.abi6378 |
0.496 |
|
| 2022 |
Sakellariou D, Bak ST, Isik E, Barroso SI, Porro A, Aguilera A, Bartek J, Janscak P, Peña-Diaz J. MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells. Cell Reports. 39: 110602. PMID 35385755 DOI: 10.1016/j.celrep.2022.110602 |
0.38 |
|
| 2021 |
Nascakova Z, Boleslavska B, Urban V, Oravetzova A, Vlachova E, Janscak P, Dobrovolna J. RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle. International Journal of Molecular Sciences. 22. PMID 33916766 DOI: 10.3390/ijms22073740 |
0.467 |
|
| 2020 |
Bauer M, Nascakova Z, Mihai AI, Cheng PF, Levesque MP, Lampart S, Hurwitz R, Pfannkuch L, Dobrovolna J, Jacobs M, Bartfeld S, Dohlman A, Shen X, Gall AA, Salama NR, ... ... Janscak P, et al. The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications. 11: 5117. PMID 33037203 DOI: 10.1038/s41467-020-18857-z |
0.405 |
|
| 2020 |
Andrs M, Hasanova Z, Oravetzova A, Dobrovolna J, Janscak P. RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription. Genes. 11. PMID 32098287 DOI: 10.3390/Genes11020232 |
0.526 |
|
| 2020 |
Chappidi N, Nascakova Z, Boleslavska B, Zellweger R, Isik E, Andrs M, Menon S, Dobrovolna J, Balbo Pogliano C, Matos J, Porro A, Lopes M, Janscak P. Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Molecular Cell. 77: 528-541.e8. PMID 31759821 DOI: 10.1016/J.Molcel.2019.10.026 |
0.611 |
|
| 2018 |
Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M. Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability. Molecular Cell. PMID 30639241 DOI: 10.1016/J.Molcel.2018.11.036 |
0.514 |
|
| 2017 |
Mijic S, Zellweger R, Chappidi N, Berti M, Jacobs K, Mutreja K, Ursich S, Ray Chaudhuri A, Nussenzweig A, Janscak P, Lopes M. Replication fork reversal triggers fork degradation in BRCA2-defective cells. Nature Communications. 8: 859. PMID 29038466 DOI: 10.1038/S41467-017-01164-5 |
0.433 |
|
| 2017 |
Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, ... Janscak P, et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell. 66: 658-671.e8. PMID 28575661 DOI: 10.1016/J.Molcel.2017.05.006 |
0.639 |
|
| 2017 |
Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH. Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling. Scientific Reports. 7: 41663. PMID 28128338 DOI: 10.1038/Srep41663 |
0.54 |
|
| 2017 |
Urban V, Dobrovolna J, Janscak P. Distinct functions of human RecQ helicases during DNA replication. Biophysical Chemistry. 225: 20-26. PMID 27876204 DOI: 10.1016/J.Bpc.2016.11.005 |
0.596 |
|
| 2016 |
Piwko W, Mlejnkova LJ, Mutreja K, Ranjha L, Stafa D, Smirnov A, Brodersen MM, Zellweger R, Sturzenegger A, Janscak P, Lopes M, Peter M, Cejka P. The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. The Embo Journal. PMID 27797818 DOI: 10.15252/Embj.201593132 |
0.593 |
|
| 2016 |
Urban V, Dobrovolna J, Hühn D, Fryzelkova J, Bartek J, Janscak P. RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. The Journal of Cell Biology. 214: 401-15. PMID 27502483 DOI: 10.1083/Jcb.201507099 |
0.55 |
|
| 2016 |
Budhathoki JB, Maleki P, Roy WA, Janscak P, Yodh JG, Balci H. A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase. Biophysical Journal. 110: 2585-2596. PMID 27332117 DOI: 10.1016/J.Bpj.2016.05.016 |
0.589 |
|
| 2016 |
Budhathoki JB, Balci H, Yodh JG, Janscak P, Maleki P, Roy W. A Comparative Study on G-Quadruplex Unfolding Activity of RecQ Helicases Biophysical Journal. 110: 635. DOI: 10.1016/J.Bpj.2015.11.3399 |
0.506 |
|
| 2015 |
Burdova K, Mihaljevic B, Sturzenegger A, Chappidi N, Janscak P. The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell. 59: 603-14. PMID 26212458 DOI: 10.1016/J.Molcel.2015.06.026 |
0.651 |
|
| 2015 |
Csefalvay E, Lapkouski M, Guzanova A, Csefalvay L, Baikova T, Shevelev I, Bialevich V, Shamayeva K, Janscak P, Kuta Smatanova I, Panjikar S, Carey J, Weiserova M, Ettrich R. Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. Plos One. 10: e0128700. PMID 26039067 DOI: 10.1371/Journal.Pone.0128700 |
0.587 |
|
| 2015 |
Budhathoki JB, Ray S, Janscak P, Yodh J, Balci H. Common Aspects of G-Quadruplex Destabilization among Helicases and Single Stranded DNA Binding Proteins Biophysical Journal. 108: 3-9. DOI: 10.1016/J.Bpj.2014.11.2189 |
0.485 |
|
| 2014 |
Chatterjee S, Zagelbaum J, Savitsky P, Sturzenegger A, Huttner D, Janscak P, Hickson ID, Gileadi O, Rothenberg E. Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications. 5: 5556. PMID 25418155 DOI: 10.1038/Ncomms6556 |
0.558 |
|
| 2014 |
Budhathoki JB, Ray S, Urban V, Janscak P, Yodh JG, Balci H. RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research. 42: 11528-45. PMID 25245947 DOI: 10.1093/Nar/Gku856 |
0.467 |
|
| 2014 |
Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P. DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells. The Journal of Biological Chemistry. 289: 27314-27326. PMID 25122754 DOI: 10.1074/Jbc.M114.578823 |
0.64 |
|
| 2014 |
Paliwal S, Kanagaraj R, Sturzenegger A, Burdova K, Janscak P. Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Research. 42: 2380-90. PMID 24319145 DOI: 10.1093/Nar/Gkt1263 |
0.626 |
|
| 2013 |
Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. The Journal of Biological Chemistry. 288: 34168-80. PMID 24108124 DOI: 10.1074/Jbc.M113.484493 |
0.645 |
|
| 2013 |
Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA. Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Molecular Cell. 50: 333-43. PMID 23623683 DOI: 10.1016/J.Molcel.2013.03.023 |
0.602 |
|
| 2012 |
Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, Hübscher U, Janscak P. Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research. 40: 8449-59. PMID 22753033 DOI: 10.1093/Nar/Gks648 |
0.629 |
|
| 2012 |
Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA. The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Nucleic Acids Research. 40: 6632-48. PMID 22544709 DOI: 10.1093/Nar/Gks349 |
0.499 |
|
| 2011 |
Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H, Ramadan K. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nature Cell Biology. 13: 1376-82. PMID 22020440 DOI: 10.1038/Ncb2367 |
0.566 |
|
| 2010 |
Kanagaraj R, Huehn D, MacKellar A, Menigatti M, Zheng L, Urban V, Shevelev I, Greenleaf AL, Janscak P. RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. Nucleic Acids Research. 38: 8131-40. PMID 20705653 DOI: 10.1093/Nar/Gkq697 |
0.499 |
|
| 2010 |
Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P. Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity Journal of Biological Chemistry. 285: 15739-15745. PMID 20348101 DOI: 10.1074/Jbc.M110.110478 |
0.621 |
|
| 2010 |
Speina E, Dawut L, Hedayati M, Wang Z, May A, Schwendener S, Janscak P, Croteau DL, Bohr VA. Human RECQL5β stimulates flap endonuclease 1 Nucleic Acids Research. 38: 2904-2916. PMID 20081208 DOI: 10.1093/Nar/Gkp1217 |
0.554 |
|
| 2009 |
Dietschy T, Shevelev I, Pena-Diaz J, Hühn D, Kuenzle S, Mak R, Miah MF, Hess D, Fey M, Hottiger MO, Janscak P, Stagljar I. p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science. 122: 1258-67. PMID 19299466 DOI: 10.1242/Jcs.037747 |
0.357 |
|
| 2009 |
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P. MRE11 complex links RECQ5 helicase to sites of DNA damage Nucleic Acids Research. 37: 2645-2657. PMID 19270065 DOI: 10.1093/Nar/Gkp147 |
0.645 |
|
| 2009 |
Yodh JG, Stevens BC, Kanagaraj R, Janscak P, Ha T. BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation. The Embo Journal. 28: 405-16. PMID 19165145 DOI: 10.1038/Emboj.2008.298 |
0.639 |
|
| 2009 |
Lapkouski M, Panjikar S, Janscak P, Smatanova IK, Carey J, Ettrich R, Csefalvay E. Structure of the motor subunit of type I restriction-modification complex EcoR124I. Nature Structural & Molecular Biology. 16: 94-5. PMID 19079266 DOI: 10.1038/Nsmb.1523 |
0.45 |
|
| 2008 |
Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M. Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. The Journal of Cell Biology. 181: 227-40. PMID 18411308 DOI: 10.1083/Jcb.200709008 |
0.529 |
|
| 2008 |
Ren H, Dou SX, Zhang XD, Wang PY, Kanagaraj R, Liu JL, Janscak P, Hu JS, Xi XG. The zinc-binding motif of human RECQ5beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme. The Biochemical Journal. 412: 425-33. PMID 18290761 DOI: 10.1042/Bj20071150 |
0.54 |
|
| 2007 |
Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes & Development. 21: 3073-84. PMID 18003859 DOI: 10.1101/Gad.1609107 |
0.549 |
|
| 2007 |
Saydam N, Kanagaraj R, Dietschy T, Garcia PL, Peña-Diaz J, Shevelev I, Stagljar I, Janscak P. Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Research. 35: 5706-16. PMID 17715146 DOI: 10.1093/Nar/Gkm500 |
0.645 |
|
| 2007 |
Jiao R, Harrigan JA, Shevelev I, Dietschy T, Selak N, Indig FE, Piotrowski J, Janscak P, Bohr VA, Stagljar I. The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage. Oncogene. 26: 3811-22. PMID 17173071 DOI: 10.1038/Sj.Onc.1210150 |
0.644 |
|
| 2006 |
Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P. Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Research. 34: 5217-31. PMID 17003056 DOI: 10.1093/Nar/Gkl677 |
0.621 |
|
| 2005 |
Cheok CF, Wu L, Garcia PL, Janscak P, Hickson ID. The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Research. 33: 3932-41. PMID 16024743 DOI: 10.1093/Nar/Gki712 |
0.663 |
|
| 2005 |
Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID. The HRDC domain of BLM is required for the dissolution of double Holliday junctions. The Embo Journal. 24: 2679-87. PMID 15990871 DOI: 10.1038/Sj.Emboj.7600740 |
0.51 |
|
| 2005 |
El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S. Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Research. 65: 3604-9. PMID 15867354 DOI: 10.1158/0008-5472.Can-04-4069 |
0.586 |
|
| 2005 |
Jindrova E, Schmid-Nuoffer S, Hamburger F, Janscak P, Bickle TA. On the DNA cleavage mechanism of Type I restriction enzymes. Nucleic Acids Research. 33: 1760-6. PMID 15788748 DOI: 10.1093/Nar/Gki322 |
0.598 |
|
| 2004 |
Garcia PL, Bradley G, Hayes CJ, Krintel S, Soultanas P, Janscak P. RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases. Nucleic Acids Research. 32: 3771-8. PMID 15256542 DOI: 10.1093/Nar/Gkh709 |
0.65 |
|
| 2004 |
Garcia PL, Liu Y, Jiricny J, West SC, Janscak P. Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. The Embo Journal. 23: 2882-91. PMID 15241474 DOI: 10.1038/Sj.Emboj.7600301 |
0.648 |
|
| 2003 |
Peakman LJ, Antognozzi M, Bickle TA, Janscak P, Szczelkun MD. S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme. Journal of Molecular Biology. 333: 321-35. PMID 14529619 DOI: 10.1016/J.Jmb.2003.08.042 |
0.502 |
|
| 2003 |
Abadjieva A, Scarlett G, Janscák P, Dutta CF, Firman K. Characterization of an EcoR124I restriction-modification enzyme produced from a deleted form of the DNA-binding subunit, which results in a novel DNA specificity. Folia Microbiologica. 48: 319-28. PMID 12879741 DOI: 10.1007/Bf02931361 |
0.622 |
|
| 2003 |
Janscak P, Garcia PL, Hamburger F, Makuta Y, Shiraishi K, Imai Y, Ikeda H, Bickle TA. Characterization and mutational analysis of the RecQ core of the bloom syndrome protein. Journal of Molecular Biology. 330: 29-42. PMID 12818200 DOI: 10.1016/S0022-2836(03)00534-5 |
0.611 |
|
| 2001 |
Janscak P, Sandmeier U, Szczelkun MD, Bickle TA. Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I. Journal of Molecular Biology. 306: 417-431. PMID 11178902 DOI: 10.1006/Jmbi.2000.4411 |
0.628 |
|
| 2000 |
Janscak P, Bickle TA. DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI. Journal of Molecular Biology. 295: 1089-1099. PMID 10656812 DOI: 10.1006/Jmbi.1999.3414 |
0.646 |
|
| 2000 |
Janscak P, Weiserova M, Hubacek J, Holubova I, Dutta CF, Firman K. Two temperature-sensitive mutations in the DNA binding subunit of EcoKI with differing properties. Fems Microbiology Letters. 182: 99-104. PMID 10612739 DOI: 10.1111/J.1574-6968.2000.Tb08881.X |
0.489 |
|
| 1999 |
Janscak P, Sandmeier U, Bickle TA. Single amino acid substitutions in the HsdR subunit of the type IB restriction enzyme EcoAI uncouple the DNA translocation and DNA cleavage activities of the enzyme. Nucleic Acids Research. 27: 2638-2643. PMID 10373579 DOI: 10.1093/Nar/27.13.2638 |
0.58 |
|
| 1999 |
Janscak P, MacWilliams MP, Sandmeier U, Nagaraja V, Bickle TA. DNA translocation blockage, a general mechanism of cleavage site selection by type I restriction enzymes. The Embo Journal. 18: 2638-2647. PMID 10228175 DOI: 10.1093/Emboj/18.9.2638 |
0.613 |
|
| 1998 |
Janscak P, Bickle TA. The DNA recognition subunit of the type IB restriction-modification enzyme EcoAI tolerates circular permutions of its polypeptide chain Journal of Molecular Biology. 284: 937-948. PMID 9837717 DOI: 10.1006/Jmbi.1998.2250 |
0.571 |
|
| 1998 |
Janscak P, Dryden DTF, Firman K. Analysis of the subunit assembly of the type IC restriction-modification enzyme EcoR124I Nucleic Acids Research. 26: 4439-4445. PMID 9742247 DOI: 10.1093/Nar/26.19.4439 |
0.521 |
|
| 1998 |
Mernagh DR, Janscak P, Firman K, Kneale GG. Protein-protein and protein-DNA interactions in the type I restriction endonuclease R.EcoR124I. Biological Chemistry. 379: 497-503. PMID 9628343 DOI: 10.1515/Bchm.1998.379.4-5.497 |
0.607 |
|
| 1997 |
Szczelkun MD, Janscak P, Firman K, Halford SE. Selection of non-specific DNA cleavage sites by the type IC restriction endonuclease EcoR124I Journal of Molecular Biology. 271: 112-123. PMID 9300058 DOI: 10.1006/Jmbi.1997.1172 |
0.598 |
|
| 1997 |
Zinkevich V, Popova L, Kryukov V, Abadjieva A, Bogdarina I, Janscak P, Firman K. The HsdR subunit of R.EcoR124II: cloning and over-expression of the gene and unexpected properties of the subunit. Nucleic Acids Research. 25: 503-510. PMID 9016588 DOI: 10.1093/Nar/25.3.503 |
0.574 |
|
| 1996 |
Janscak P, Abadjieva A, Firman K. The Type I Restriction Endonuclease R.EcoR124I: Over-production and Biochemical Properties Journal of Molecular Biology. 257: 977-991. PMID 8632480 DOI: 10.1006/Jmbi.1996.0217 |
0.553 |
|
| 1993 |
Weiserova M, Janscak P, Benada O, Hubácek J, Zinkevich VE, Glover SW, Firman K. Cloning, production and characterisation of wild type and mutant forms of the R.EcoK endonucleases. Nucleic Acids Research. 21: 373-9. PMID 8441649 DOI: 10.1093/Nar/21.3.373 |
0.548 |
|
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