J. Lindsay Whitton - Publications

Affiliations: 
Immunology and Microbiology Scripps Research Institute, La Jolla, La Jolla, CA, United States 

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Alirezaei M, Flynn CT, Wood MR, Harkins S, Whitton JL. Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo. Autophagy. 0. PMID 26090585 DOI: 10.1080/15548627.2015.1063769  0.88
2014 Hosking MP, Flynn CT, Whitton JL. Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect. Journal of Immunology (Baltimore, Md. : 1950). 193: 1873-85. PMID 25015828 DOI: 10.4049/jimmunol.1400348  0.88
2014 Robinson SM, Tsueng G, Sin J, Mangale V, Rahawi S, McIntyre LL, Williams W, Kha N, Cruz C, Hancock BM, Nguyen DP, Sayen MR, Hilton BJ, Doran KS, Segall AM, ... ... Whitton JL, et al. Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. Plos Pathogens. 10: e1004045. PMID 24722773 DOI: 10.1371/journal.ppat.1004045  0.88
2013 Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK. Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 5655-68. PMID 24146043 DOI: 10.4049/jimmunol.1301215  0.44
2013 Hosking MP, Flynn CT, Botten J, Whitton JL. CD8+ memory T cells appear exhausted within hours of acute virus infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 4211-22. PMID 24026080 DOI: 10.4049/jimmunol.1300920  0.88
2012 Kemball CC, Flynn CT, Hosking MP, Botten J, Whitton JL. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology. 429: 74-90. PMID 22551767 DOI: 10.1016/j.virol.2012.04.005  0.88
2012 Alirezaei M, Flynn CT, Wood MR, Whitton JL. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host & Microbe. 11: 298-305. PMID 22423969 DOI: 10.1016/j.chom.2012.01.014  0.88
2012 Ruller CM, Tabor-Godwin JM, Van Deren DA, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R. Neural stem cell depletion and CNS developmental defects after enteroviral infection. The American Journal of Pathology. 180: 1107-20. PMID 22214838 DOI: 10.1016/j.ajpath.2011.11.016  0.88
2011 Moore CS, Milner R, Nishiyama A, Frausto RF, Serwanski DR, Pagarigan RR, Whitton JL, Miller RH, Crocker SJ. Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6247-54. PMID 21508247 DOI: 10.1523/JNEUROSCI.5474-10.2011  0.88
2011 Tsueng G, Tabor-Godwin JM, Gopal A, Ruller CM, Deline S, An N, Frausto RF, Milner R, Crocker SJ, Whitton JL, Feuer R. Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells. Journal of Virology. 85: 5718-32. PMID 21471247 DOI: 10.1128/JVI.02261-10  0.44
2011 Crocker SJ, Bajpai R, Moore CS, Frausto RF, Brown GD, Pagarigan RR, Whitton JL, Terskikh AV. Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination. Neuropathology and Applied Neurobiology. 37: 643-53. PMID 21276029 DOI: 10.1111/j.1365-2990.2011.01165.x  0.88
2010 Kemball CC, Alirezaei M, Flynn CT, Wood MR, Harkins S, Kiosses WB, Whitton JL. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. Journal of Virology. 84: 12110-24. PMID 20861268 DOI: 10.1128/JVI.01417-10  0.88
2010 Kemball CC, Alirezaei M, Whitton JL. Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiology. 5: 1329-47. PMID 20860480 DOI: 10.2217/fmb.10.101  0.88
2010 Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ. A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. Journal of Virology. 84: 9947-56. PMID 20668086 DOI: 10.1128/JVI.00672-10  0.44
2010 Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R. A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8676-91. PMID 20573913 DOI: 10.1523/JNEUROSCI.1860-10.2010  0.88
2010 Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 6: 702-10. PMID 20534972 DOI: 10.4161/auto.6.6.12376  0.88
2009 Kemball CC, Harkins S, Whitmire JK, Flynn CT, Feuer R, Whitton JL. Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway. Plos Pathogens. 5: e1000618. PMID 19834548 DOI: 10.1371/journal.ppat.1000618  0.88
2009 Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL. Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. Journal of Virology. 83: 9356-69. PMID 19570873 DOI: 10.1128/JVI.02382-07  0.88
2009 Whitmire JK, Eam B, Whitton JL. Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. European Journal of Immunology. 39: 1494-504. PMID 19384870 DOI: 10.1002/eji.200838959  0.44
2009 Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy. 5: 152-8. PMID 19066443 DOI: 10.4161/auto.5.2.7348  0.88
2008 Theil DJ, Libbey JE, Rodriguez F, Whitton JL, Tsunoda I, Derfuss TJ, Fujinami RS. Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 204: 92-100. PMID 18706703 DOI: 10.1016/j.jneuroim.2008.07.005  0.88
2008 Whitmire JK, Benning N, Eam B, Whitton JL. Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. Journal of Immunology (Baltimore, Md. : 1950). 180: 6777-85. PMID 18453598  0.44
2008 Crocker SJ, Frausto RF, Whitton JL, Milner R. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia. 56: 1187-98. PMID 18449943 DOI: 10.1002/glia.20689  0.44
2008 Whitmire JK, Eam B, Whitton JL. Tentative T cells: memory cells are quick to respond, but slow to divide. Plos Pathogens. 4: e1000041. PMID 18404208 DOI: 10.1371/journal.ppat.1000041  0.44
2008 Kemball CC, Harkins S, Whitton JL. Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection. Journal of Virology. 82: 4331-42. PMID 18305030 DOI: 10.1128/JVI.02639-07  0.88
2007 Foster B, Prussin C, Liu F, Whitmire JK, Whitton JL. Detection of intracellular cytokines by flow cytometry. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 6.24. PMID 18432993 DOI: 10.1002/0471142735.im0624s78  0.44
2007 Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL. Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. The American Journal of Pathology. 171: 1762-73. PMID 18055551 DOI: 10.2353/ajpath.2007.070179  0.44
2007 Frausto RF, Crocker SJ, Eam B, Whitmire JK, Whitton JL. Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. Journal of Neuroimmunology. 192: 124-33. PMID 17964666 DOI: 10.1016/j.jneuroim.2007.09.024  0.44
2007 Whitmire JK, Eam B, Benning N, Whitton JL. Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 179: 1190-7. PMID 17617612  0.44
2007 Cornell CT, Kiosses WB, Harkins S, Whitton JL. Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. Journal of Virology. 81: 6785-97. PMID 17442717 DOI: 10.1128/JVI.00198-07  0.88
2007 Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Ting JP, Bui HH, Sette A, Buchmeier MJ. HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. Journal of Virology. 81: 2307-17. PMID 17166907 DOI: 10.1128/JVI.02063-06  0.88
2007 Hunziker IP, Cornell CT, Whitton JL. Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication. Virology. 360: 120-8. PMID 17084431 DOI: 10.1016/j.virol.2006.09.041  0.88
2007 Libbey JE, Tsunoda I, Whitton JL, Fujinami RS. Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus. Journal of Virology. 81: 3009-11. PMID 17005653 DOI: 10.1128/JVI.01663-06  0.88
2006 Crocker SJ, Whitmire JK, Frausto RF, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. The American Journal of Pathology. 169: 2104-16. PMID 17148673 DOI: 10.2353/ajpath.2006.060626  0.44
2006 Fernandez-Borges N, Brun A, Whitton JL, Parra B, Diaz-San Segundo F, Salguero FJ, Torres JM, Rodriguez F. DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge. Journal of Virology. 80: 9970-6. PMID 17005675 DOI: 10.1128/JVI.01210-06  0.72
2006 Cornell CT, Kiosses WB, Harkins S, Whitton JL. Inhibition of protein trafficking by coxsackievirus b3: multiple viral proteins target a single organelle. Journal of Virology. 80: 6637-47. PMID 16775351 DOI: 10.1128/JVI.02572-05  0.88
2006 Whitmire JK, Benning N, Whitton JL. Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 3028-36. PMID 16493061  0.44
2006 Fujinami RS, von Herrath MG, Christen U, Whitton JL. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clinical Microbiology Reviews. 19: 80-94. PMID 16418524 DOI: 10.1128/CMR.19.1.80-94.2006  1
2005 Whitmire JK, Benning N, Whitton JL. Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 175: 5624-8. PMID 16237051  0.44
2005 Whitton JL, Cornell CT, Feuer R. Host and virus determinants of picornavirus pathogenesis and tropism. Nature Reviews. Microbiology. 3: 765-76. PMID 16205710 DOI: 10.1038/nrmicro1284  0.88
2005 Whitmire JK, Tan JT, Whitton JL. Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection Journal of Experimental Medicine. 201: 1053-1059. PMID 15809350 DOI: 10.1084/jem.20041463  0.88
2005 Feuer R, Pagarigan RR, Harkins S, Liu F, Hunziker IP, Whitton JL. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS Journal of Neuroscience. 25: 2434-2444. PMID 15745971 DOI: 10.1523/JNEUROSCI.4517-04.2005  0.88
2005 Harkins S, Cornell CT, Whitton JL. Analysis of translational initiation in coxsackievirus B3 suggests an alternative explanation for the high frequency of R+4 in the eukaryotic consensus motif. Journal of Virology. 79: 987-96. PMID 15613327 DOI: 10.1128/JVI.79.2.987-996.2005  0.88
2004 Whitton JL, Slifka MK, Liu F, Nussbaum AK, Whitmire JK. The regulation and maturation of antiviral immune responses. Advances in Virus Research. 63: 181-238. PMID 15530562 DOI: 10.1016/S0065-3527(04)63003-X  0.44
2004 Hunziker IP, Harkins S, Feuer R, Cornell CT, Whitton JL. Generation and analysis of an RNA vaccine that protects against coxsackievirus B3 challenge. Virology. 330: 196-208. PMID 15527846 DOI: 10.1016/j.virol.2004.09.035  0.88
2004 Leifert JA, Rodriguez-Carreno MP, Rodriguez F, Whitton JL. Targeting plasmid-encoded proteins to the antigen presentation pathways. Immunological Reviews. 199: 40-53. PMID 15233725 DOI: 10.1111/j.0105-2896.2004.0135.x  0.72
2003 von Herrath MG, Fujinami RS, Whitton JL. Microorganisms and autoimmunity: making the barren field fertile? Nature Reviews. Microbiology. 1: 151-7. PMID 15035044 DOI: 10.1038/nrmicro754  1
2003 Leifert JA, Holler PD, Harkins S, Kranz DM, Whitton JL. The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes. Gene Therapy. 10: 2067-73. PMID 14595379 DOI: 10.1038/sj.gt.3302115  0.88
2003 Feuer R, Mena I, Pagarigan RR, Harkins S, Hassett DE, Whitton JL. Coxsackievirus B3 and the neonatal CNS: The roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease American Journal of Pathology. 163: 1379-1393. PMID 14507646  0.88
2002 Leifert JA, Harkins S, Whitton JL. Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity Gene Therapy. 9: 1422-1428. PMID 12378404 DOI: 10.1038/sj.gt.3301819  0.88
2002 Rodriguez F, Harkins S, Slifka MK, Whitton JL. Immunodominance in virus-induced CD8+ T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon Journal of Virology. 76: 4251-4259. PMID 11932390 DOI: 10.1128/JVI.76.9.4251-4259.2002  0.88
2002 Harrington LE, Most Rv Rv, Whitton JL, Ahmed R. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. Journal of Virology. 76: 3329-37. PMID 11884558 DOI: 10.1128/JVI.76.7.3329-3337.2002  0.88
2001 Rodriguez F, Harkins S, Redwine JM, De Pereda JM, Whitton JL. CD4+ T cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting Journal of Virology. 75: 10421-10430. PMID 11581410 DOI: 10.1128/JVI.75.21.10421-10430.2001  0.88
2001 Theil DJ, Tsunoda I, Rodriguez F, Whitton JL, Fujinami RS. Viruses can silently prime for and trigger central nervous system autoimmune disease Journal of Neurovirology. 7: 220-227. PMID 11517396 DOI: 10.1080/13550280152403263  0.88
2001 Rodriguez F, Slifka MK, Harkins S, Whitton JL. Two overlapping subdominant epitopes identified by DNA immunization induce protective CD8+ T-cell populations with differing cytolytic activities Journal of Virology. 75: 7399-7409. PMID 11462012 DOI: 10.1128/JVI.75.16.7399-7409.2001  0.88
2001 Whitton JL, Fujinami RS. DNA immunization and central nervous system viral infection. Advances in Virus Research. 56: 243-73. PMID 11450302 DOI: 10.1016/s0065-3527(01)56030-3  1
2000 von Herrath MG, Whitton JL. DNA vaccination to treat autoimmune diabetes. Annals of Medicine. 32: 285-92. PMID 10949059 DOI: 10.3109/07853890008995930  0.56
2000 Mena I, Fischer C, Gebhard JR, Perry CM, Harkins S, Whitton JL. Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology Virology. 271: 276-288. PMID 10860882 DOI: 10.1006/viro.2000.0332  0.88
2000 Xiang R, Lode HN, Chao TH, Ruehlmann JM, Dolman CS, Rodriguez F, Whitton JL, Overwijk WW, Restifo NP, Reisfeld RA. An autologous oral DNA vaccine protects against murine melanoma. Proceedings of the National Academy of Sciences of the United States of America. 97: 5492-7. PMID 10779556 DOI: 10.1073/pnas.090097697  0.88
2000 An LL, Rodriguez F, Harkins S, Zhang J, Whitton JL. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine Vaccine. 18: 2132-2141. PMID 10715528 DOI: 10.1016/S0264-410X(99)00546-0  0.88
2000 Sevilla N, Homann D, von Herrath M, Rodriguez F, Harkins S, Whitton JL, Oldstone MB. Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease. Journal of Virology. 74: 3284-92. PMID 10708445  0.72
2000 Rodriguez F, Whitton JL. Enhancing DNA immunization. Virology. 268: 233-8. PMID 10704331 DOI: 10.1006/viro.2000.0209  0.72
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