| Year |
Citation |
Score |
| 2023 |
Taylor A, Zhang S, Johannissen LO, Sakuma M, Phillips RS, Green AP, Hay S, Heyes DJ, Scrutton NS. Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase. The Febs Journal. PMID 38060334 DOI: 10.1111/febs.17025 |
0.385 |
|
| 2023 |
Faulkner M, Hoeven R, Kelly PP, Sun Y, Park H, Liu LN, Toogood HS, Scrutton NS. Chemoautotrophic production of gaseous hydrocarbons, bioplastics and osmolytes by a novel Halomonas species. Biotechnology For Biofuels and Bioproducts. 16: 152. PMID 37821908 DOI: 10.1186/s13068-023-02404-1 |
0.712 |
|
| 2023 |
Zhao J, Zhuo Y, Diaz DE, Shanmugam M, Telfer AJ, Lindley PJ, Kracher D, Hayashi T, Seibt LS, Hardy FJ, Manners O, Hedison TM, Hollywood KA, Spiess R, Cain KM, ... ... Scrutton NS, et al. Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase. Journal of the American Chemical Society. PMID 37688545 DOI: 10.1021/jacs.3c06607 |
0.362 |
|
| 2023 |
Scrutton NS. Unravelling the complexity of enzyme catalysis. The Febs Journal. 290: 2204-2207. PMID 37132524 DOI: 10.1111/febs.16796 |
0.343 |
|
| 2022 |
Barker RD, Yu Y, De Maria L, Johannissen LO, Scrutton NS. Mechanism of Action of Flavin-Dependent Halogenases. Acs Catalysis. 12: 15352-15360. PMID 36570077 DOI: 10.1021/acscatal.2c05231 |
0.309 |
|
| 2022 |
Johannissen LO, Taylor A, Hardman SJO, Heyes DJ, Scrutton NS, Hay S. How Photoactivation Triggers Protochlorophyllide Reduction: Computational Evidence of a Stepwise Hydride Transfer during Chlorophyll Biosynthesis. Acs Catalysis. 12: 4141-4148. PMID 35574213 DOI: 10.1021/acscatal.2c00866 |
0.319 |
|
| 2022 |
Leferink NGH, Escorcia AM, Ouwersloot BR, Johanissen LO, Hay S, van der Kamp MW, Scrutton N. Molecular determinants for carbocation cyclisation in bacterial monoterpene synthases. Chembiochem : a European Journal of Chemical Biology. PMID 35005823 DOI: 10.1002/cbic.202100688 |
0.344 |
|
| 2020 |
Trisrivirat D, Hughes JMX, Hoeven R, Faulkner M, Toogood H, Chaiyen P, Scrutton NS. Promoter engineering for microbial bio-alkane gas production. Synthetic Biology (Oxford, England). 5: ysaa022. PMID 33263086 DOI: 10.1093/synbio/ysaa022 |
0.733 |
|
| 2020 |
Heyes DJ, Lakavath B, Hardman SJO, Sakuma M, Hedison TM, Scrutton NS. Photochemical Mechanism of Light-Driven Fatty Acid Photodecarboxylase. Acs Catalysis. 10: 6691-6696. PMID 32905273 DOI: 10.1021/acscatal.0c01684 |
0.319 |
|
| 2020 |
Amer M, Hoeven R, Kelly P, Faulkner M, Smith MH, Toogood HS, Scrutton NS. Renewable and tuneable bio-LPG blends derived from amino acids. Biotechnology For Biofuels. 13: 125. PMID 32684978 DOI: 10.1186/S13068-020-01766-0 |
0.735 |
|
| 2020 |
Lakavath B, Hedison TM, Heyes DJ, Shanmugam M, Sakuma M, Hoeven R, Tilakaratna V, Scrutton NS. Radical-based photoinactivation of fatty acid photodecarboxylases. Analytical Biochemistry. 600: 113749. PMID 32348726 DOI: 10.1016/J.Ab.2020.113749 |
0.772 |
|
| 2020 |
Amer M, Wojcik EZ, Sun C, Hoeven R, Hughes JMX, Faulkner M, Yunus IS, Tait S, Johannissen LO, Hardman SJO, Heyes DJ, Chen G, Smith MH, Jones PR, Toogood HS, ... Scrutton NS, et al. Low carbon strategies for sustainable bio-alkane gas production and renewable energy Energy and Environmental Science. 13: 1818-1831. DOI: 10.1039/D0Ee00095G |
0.719 |
|
| 2019 |
Hedison TM, Shenoy RT, Iorgu AI, Heyes DJ, Fisher K, Wright GSA, Hay S, Eady RR, Antonyuk SV, Hasnain SS, Scrutton NS. Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis. Acs Catalysis. 9: 6087-6099. PMID 32051772 DOI: 10.1021/Acscatal.9B01266 |
0.348 |
|
| 2019 |
Zhang S, Heyes DJ, Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, ... ... Scrutton NS, et al. Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature. PMID 31645759 DOI: 10.1038/S41586-019-1685-2 |
0.774 |
|
| 2019 |
Kearsey LJ, Prandi N, Karuppiah V, Yan C, Leys D, Toogood H, Takano E, Scrutton NS. Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in Type III polyketide synthases. The Febs Journal. PMID 31605668 DOI: 10.1111/febs.15089 |
0.393 |
|
| 2019 |
Johannissen LO, Iorgu AI, Scrutton NS, Hay S. What are the signatures of tunnelling in enzyme-catalysed reactions? Faraday Discussions. 221: 367-378. PMID 31544181 DOI: 10.1039/C9Fd00044E |
0.398 |
|
| 2019 |
Leferink NGH, Ranaghan KE, Karuppiah V, Currin A, van der Kamp MW, Mulholland AJ, Scrutton NS. Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome. Acs Catalysis. 8: 3780-3791. PMID 31157124 DOI: 10.1021/acscatal.8b00692 |
0.307 |
|
| 2019 |
Iorgu AI, Cliff MJ, Waltho JP, Scrutton NS, Hay S. Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms. Methods in Enzymology. 620: 145-166. PMID 31072485 DOI: 10.1016/Bs.Mie.2019.03.009 |
0.301 |
|
| 2019 |
Iorgu AI, Hedison TM, Hay S, Scrutton NS. Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene-reductases. The Febs Journal. 286: 3117-3128. PMID 31033202 DOI: 10.1111/febs.14862 |
0.37 |
|
| 2019 |
Sutcliffe MJ, Scrutton NS. Enzymology takes a quantum leap forward. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 358: 367-386. PMID 20396604 DOI: 10.1098/rsta.2000.0536 |
0.346 |
|
| 2018 |
Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS. Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase. Acs Catalysis. 8: 2012-2020. PMID 29750129 DOI: 10.1021/Acscatal.7B04115 |
0.396 |
|
| 2017 |
Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS. Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase. Acs Catalysis. 7: 6268-6282. PMID 28966840 DOI: 10.1021/Acscatal.7B01924 |
0.35 |
|
| 2017 |
Swainston N, Batista-Navarro R, Carbonell P, Dobson PD, Dunstan M, Jervis AJ, Vinaixa M, Williams AR, Ananiadou S, Faulon JL, Mendes P, Kell DB, Scrutton NS, Breitling R. biochem4j: Integrated and extensible biochemical knowledge through graph databases. Plos One. 12: e0179130. PMID 28708831 DOI: 10.1371/Journal.Pone.0179130 |
0.311 |
|
| 2017 |
Waller J, Toogood HS, Karuppiah V, Rattray NJW, Mansell DJ, Leys D, Gardiner JM, Fryszkowska A, Ahmed ST, Bandichhor R, Reddy GP, Scrutton NS. Structural insights into the ene-reductase synthesis of profens. Organic & Biomolecular Chemistry. PMID 28485453 DOI: 10.1039/C7Ob00163K |
0.481 |
|
| 2016 |
Longbotham JE, Hardman SJ, Görlich S, Scrutton NS, Hay S. Untangling heavy protein and cofactor isotope effects on enzyme- catalyzed hydride transfer. Journal of the American Chemical Society. PMID 27676389 DOI: 10.1021/jacs.6b07852 |
0.346 |
|
| 2016 |
Lygidakis A, Karuppiah V, Hoeven R, Ní Cheallaigh A, Leys D, Gardiner JM, Toogood HS, Scrutton NS. Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 128: 9748-9752. PMID 27587903 DOI: 10.1002/ange.201603785 |
0.781 |
|
| 2016 |
Hedison TM, Leferink NG, Hay S, Scrutton NS. Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap. Acs Catalysis. 6: 5170-5180. PMID 27563493 DOI: 10.1021/acscatal.6b01280 |
0.317 |
|
| 2016 |
Lygidakis A, Karuppiah V, Hoeven R, Ní Cheallaigh A, Leys D, Gardiner JM, Toogood HS, Scrutton NS. Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angewandte Chemie (International Ed. in English). PMID 27411040 DOI: 10.1002/Anie.201603785 |
0.781 |
|
| 2016 |
Menon BR, Hardman SJ, Scrutton NS, Heyes DJ. Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR). Journal of Photochemistry and Photobiology. B, Biology. 161: 236-43. PMID 27285815 DOI: 10.1016/j.jphotobiol.2016.05.029 |
0.388 |
|
| 2016 |
Hoeven R, Hardman SJ, Heyes DJ, Scrutton NS. Cross-Species Analysis of Protein Dynamics Associated with Hydride and Proton Transfer in the Catalytic Cycle of the Light-Driven Enzyme Protochlorophyllide Oxidoreductase. Biochemistry. 55: 903-13. PMID 26807652 DOI: 10.1021/Acs.Biochem.5B01355 |
0.771 |
|
| 2015 |
Peers MK, Toogood HS, Heyes DJ, Mansell D, Coe BJ, Scrutton NS. Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers. Catalysis Science & Technology. 6: 169-177. PMID 27019691 DOI: 10.1039/c5cy01642h |
0.306 |
|
| 2015 |
Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. Biochemistry. 54: 6093-105. PMID 26368022 DOI: 10.1021/Acs.Biochem.5B00789 |
0.322 |
|
| 2015 |
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D. New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. Nature. 522: 497-501. PMID 26083754 DOI: 10.1038/Nature14560 |
0.346 |
|
| 2015 |
Hoeven R, Heyes DJ, Hay S, Scrutton NS. Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions? The Febs Journal. 282: 3243-55. PMID 25581554 DOI: 10.1111/Febs.13193 |
0.734 |
|
| 2015 |
Heyes DJ, Hardman SJ, Hedison TM, Hoeven R, Greetham GM, Towrie M, Scrutton NS. Excited-state charge separation in the photochemical mechanism of the light-driven enzyme protochlorophyllide oxidoreductase. Angewandte Chemie (International Ed. in English). 54: 1512-5. PMID 25488797 DOI: 10.1002/Anie.201409881 |
0.761 |
|
| 2015 |
Radford SE, Scrutton NS. Professor Richard Nelson Perham, FRS, FMedSci The Biochemist. 37: 58-59. DOI: 10.1042/bio03703058 |
0.356 |
|
| 2014 |
Pang J, Scrutton NS, Sutcliffe MJ. Quantum mechanics/molecular mechanics studies on the mechanism of action of cofactor pyridoxal 5'-phosphate in ornithine 4,5-aminomutase. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 11390-401. PMID 25048616 DOI: 10.1002/chem.201402759 |
0.314 |
|
| 2014 |
Leferink NG, Antonyuk SV, Houwman JA, Scrutton NS, Eady RR, Hasnain SS. Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications. 5: 4395. PMID 25022223 DOI: 10.1038/ncomms5395 |
0.398 |
|
| 2014 |
Pudney CR, Hay S, Scrutton NS. Practical aspects on the use of kinetic isotope effects as probes of flavoprotein enzyme mechanisms. Methods in Molecular Biology (Clifton, N.J.). 1146: 161-75. PMID 24764092 DOI: 10.1007/978-1-4939-0452-5_8 |
0.328 |
|
| 2014 |
Hernandez-Ortega A, Quesne MG, Bui S, Heuts DP, Steiner RA, Heyes DJ, de Visser SP, Scrutton NS. Origin of the proton-transfer step in the cofactor-free (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase: effect of the basicity of an active site His residue. The Journal of Biological Chemistry. 289: 8620-32. PMID 24482238 DOI: 10.1074/Jbc.M113.543033 |
0.316 |
|
| 2013 |
Mansell DJ, Toogood HS, Waller J, Hughes JM, Levy CW, Gardiner JM, Scrutton NS. Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum. Acs Catalysis. 3: 370-379. PMID 27547488 DOI: 10.1021/Cs300709M |
0.371 |
|
| 2013 |
Jones AR, Levy C, Hay S, Scrutton NS. Relating localized protein motions to the reaction coordinate in coenzyme B₁₂-dependent enzymes. The Febs Journal. 280: 2997-3008. PMID 23462350 DOI: 10.1111/febs.12223 |
0.336 |
|
| 2013 |
Fisher K, Mohr S, Mansell D, Goddard NJ, Fielden PR, Scrutton NS. Electro-enzymatic viologen-mediated substrate reduction using pentaerythritol tetranitrate reductase and a parallel, segmented fluid flow system Catalysis Science & Technology. 3: 1505-1511. DOI: 10.1039/C3Cy20720J |
0.355 |
|
| 2012 |
Scrutton NS, Groot ML, Heyes DJ. Excited state dynamics and catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase Physical Chemistry Chemical Physics. 14: 8818-8824. PMID 22419074 DOI: 10.1039/C2Cp23789J |
0.316 |
|
| 2011 |
Meints CE, Gustafsson FS, Scrutton NS, Wolthers KR. Tryptophan 697 modulates hydride and interflavin electron transfer in human methionine synthase reductase. Biochemistry. 50: 11131-42. PMID 22097960 DOI: 10.1021/bi2012228 |
0.313 |
|
| 2011 |
Makins C, Miros FN, Scrutton NS, Wolthers KR. Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase. Bioorganic Chemistry. 40: 39-47. PMID 21899873 DOI: 10.1016/j.bioorg.2011.08.003 |
0.331 |
|
| 2011 |
Toogood HS, Fryszkowska A, Hulley M, Sakuma M, Mansell D, Stephens GM, Gardiner JM, Scrutton NS. A site-saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity. Chembiochem : a European Journal of Chemical Biology. 12: 738-49. PMID 21374779 DOI: 10.1002/Cbic.201000662 |
0.313 |
|
| 2011 |
Heyes DJ, Levy C, Sakuma M, Robertson DL, Scrutton NS. A twin-track approach has optimized proton and hydride transfer by dynamically coupled tunneling during the evolution of protochlorophyllide oxidoreductase. The Journal of Biological Chemistry. 286: 11849-54. PMID 21317291 DOI: 10.1074/jbc.M111.219626 |
0.331 |
|
| 2011 |
Fryszkowska A, Toogood H, Sakuma M, Stephens GM, Gardiner JM, Scrutton NS. Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins Catalysis Science and Technology. 1: 948-957. DOI: 10.1039/C0Cy00092B |
0.334 |
|
| 2010 |
Hulley ME, Toogood HS, Fryszkowska A, Mansell D, Stephens GM, Gardiner JM, Scrutton NS. Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site-saturated libraries. Chembiochem : a European Journal of Chemical Biology. 11: 2433-47. PMID 21064170 DOI: 10.1002/Cbic.201000527 |
0.366 |
|
| 2010 |
Adalbjörnsson BV, Toogood HS, Fryszkowska A, Pudney CR, Jowitt TA, Leys D, Scrutton NS. Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme. Chembiochem : a European Journal of Chemical Biology. 11: 197-207. PMID 19943268 DOI: 10.1002/cbic.200900570 |
0.341 |
|
| 2010 |
Menon BR, Davison PA, Hunter CN, Scrutton NS, Heyes DJ. Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase. The Journal of Biological Chemistry. 285: 2113-9. PMID 19850924 DOI: 10.1074/jbc.M109.071522 |
0.384 |
|
| 2010 |
Toogood HS, Gardiner JM, Scrutton NS. Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases Chemcatchem. 2: 892-914. DOI: 10.1002/Cctc.201000094 |
0.324 |
|
| 2009 |
Heyes DJ, Levy C, Lafite P, Roberts IS, Goldrick M, Stachulski AV, Rossington SB, Stanford D, Rigby SE, Scrutton NS, Leys D. Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. The Journal of Biological Chemistry. 284: 35514-23. PMID 19815542 DOI: 10.1074/jbc.M109.056630 |
0.319 |
|
| 2009 |
Pudney CR, Hay S, Scrutton NS. Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase. The Febs Journal. 276: 4780-9. PMID 19664062 DOI: 10.1111/j.1742-4658.2009.07179.x |
0.37 |
|
| 2009 |
Menon BR, Waltho JP, Scrutton NS, Heyes DJ. Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase. The Journal of Biological Chemistry. 284: 18160-6. PMID 19439417 DOI: 10.1074/Jbc.M109.020719 |
0.418 |
|
| 2009 |
Heuts DP, Scrutton NS, McIntire WS, Fraaije MW. What's in a covalent bond? On the role and formation of covalently bound flavin cofactors. The Febs Journal. 276: 3405-27. PMID 19438712 DOI: 10.1111/j.1742-4658.2009.07053.x |
0.323 |
|
| 2009 |
Pudney CR, McGrory T, Lafite P, Pang J, Hay S, Leys D, Sutcliffe MJ, Scrutton NS. Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure. Chembiochem : a European Journal of Chemical Biology. 10: 1379-84. PMID 19405065 DOI: 10.1002/cbic.200900071 |
0.326 |
|
| 2009 |
Heyes DJ, Scrutton NS. Conformational changes in the catalytic cycle of protochlorophyllide oxidoreductase: what lessons can be learnt from dihydrofolate reductase? Biochemical Society Transactions. 37: 354-7. PMID 19290861 DOI: 10.1042/BST0370354 |
0.367 |
|
| 2009 |
Munro AW, Scrutton NS. Enzyme mechanisms: fast reaction and computational approaches. Biochemical Society Transactions. 37: 333-5. PMID 19290857 DOI: 10.1042/BST0370333 |
0.316 |
|
| 2008 |
Heyes DJ, Menon BR, Sakuma M, Scrutton NS. Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase. Biochemistry. 47: 10991-8. PMID 18798649 DOI: 10.1021/bi801521c |
0.374 |
|
| 2008 |
Dunn RV, Marshall KR, Munro AW, Scrutton NS. The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex Febs Journal. 275: 3850-3858. PMID 18573102 DOI: 10.1111/j.1742-4658.2008.06532.x |
0.338 |
|
| 2008 |
Burgess SG, Messiha HL, Katona G, Rigby SE, Leys D, Scrutton NS. Probing the dynamic interface between trimethylamine dehydrogenase (TMADH) and electron transferring flavoprotein (ETF) in the TMADH-2ETF complex: role of the Arg-alpha237 (ETF) and Tyr-442 (TMADH) residue pair. Biochemistry. 47: 5168-81. PMID 18407658 DOI: 10.1021/bi800127d |
0.591 |
|
| 2008 |
Hothi P, Lee M, Cullis PM, Leys D, Scrutton NS. Catalysis by the Isolated Tryptophan Tryptophylquinone-Containing Subunit of Aromatic Amine Dehydrogenase Is Distinct from Native Enzyme and Synthetic Model Compounds and Allows Further Probing of TTQ Mechanism† Biochemistry. 47: 183-194. PMID 18052255 DOI: 10.1021/Bi701690U |
0.354 |
|
| 2007 |
Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS. Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. Journal of the American Chemical Society. 129: 13949-56. PMID 17939663 DOI: 10.1021/JA074463H |
0.336 |
|
| 2007 |
Monaghan PJ, Leys D, Scrutton NS. Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase/oxidase. The Febs Journal. 274: 2070-87. PMID 17371548 DOI: 10.1111/j.1742-4658.2007.05750.x |
0.339 |
|
| 2006 |
Sutcliffe MJ, Scrutton NS. Computational studies of enzyme mechanism: linking theory with experiment in the analysis of enzymic H-tunnelling. Physical Chemistry Chemical Physics : Pccp. 8: 4510-6. PMID 17047748 DOI: 10.1039/B609622K |
0.306 |
|
| 2006 |
Basran J, Fullerton S, Leys D, Scrutton NS. Mechanism of FAD reduction and role of active site residues His-225 and Tyr-259 in Arthrobacter globiformis dimethylglycine oxidase: analysis of mutant structure and catalytic function. Biochemistry. 45: 11151-61. PMID 16964976 DOI: 10.1021/BI061094D |
0.442 |
|
| 2006 |
Combe JP, Basran J, Hothi P, Leys D, Rigby SE, Munro AW, Scrutton NS. Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis. The Journal of Biological Chemistry. 281: 17977-88. PMID 16624811 DOI: 10.1074/jbc.M601417200 |
0.334 |
|
| 2006 |
Polticelli F, Basran J, Faso C, Cona A, Minervini G, Angelini R, Federico R, Scrutton NS, Tavladoraki P. Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase. Biochemistry. 44: 16108-20. PMID 16331971 DOI: 10.1021/BI050983I |
0.404 |
|
| 2005 |
Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW. The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase. Febs Letters. 579: 5582-8. PMID 16214136 DOI: 10.1016/J.Febslet.2005.09.023 |
0.317 |
|
| 2005 |
Khan H, Barna T, Bruce NC, Munro AW, Leys D, Scrutton NS. Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase. Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181, His184. The Febs Journal. 272: 4660-71. PMID 16156787 DOI: 10.1111/j.1742-4658.2005.04875.x |
0.409 |
|
| 2005 |
Warman AJ, Roitel O, Neeli R, Girvan HM, Seward HE, Murray SA, McLean KJ, Joyce MG, Toogood H, Holt RA, Leys D, Scrutton NS, Munro AW. Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme. Biochemical Society Transactions. 33: 747-53. PMID 16042591 DOI: 10.1042/Bst0330747 |
0.402 |
|
| 2005 |
Messiha HL, Bruce NC, Sattelle BM, Sutcliffe MJ, Munro AW, Scrutton NS. Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase. The Journal of Biological Chemistry. 280: 27103-10. PMID 15905167 DOI: 10.1074/jbc.M502293200 |
0.398 |
|
| 2005 |
Neeli R, Roitel O, Scrutton NS, Munro AW. Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes. The Journal of Biological Chemistry. 280: 17634-44. PMID 15710617 DOI: 10.1074/JBC.M413826200 |
0.327 |
|
| 2005 |
Messiha HL, Munro AW, Bruce NC, Barsukov I, Scrutton NS. Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189. The Journal of Biological Chemistry. 280: 10695-709. PMID 15632179 DOI: 10.1074/jbc.M410595200 |
0.372 |
|
| 2004 |
Scrutton NS. Chemical aspects of amine oxidation by flavoprotein enzymes. Natural Product Reports. 21: 722-30. PMID 15565251 DOI: 10.1039/B306788M |
0.308 |
|
| 2004 |
Williams RE, Rathbone DA, Scrutton NS, Bruce NC. Biotransformation of explosives by the old yellow enzyme family of flavoproteins. Applied and Environmental Microbiology. 70: 3566-74. PMID 15184158 DOI: 10.1128/AEM.70.6.3566-3574.2004 |
0.38 |
|
| 2004 |
Khan H, Barna T, Harris RJ, Bruce NC, Barsukov I, Munro AW, Moody PC, Scrutton NS. Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation. The Journal of Biological Chemistry. 279: 30563-72. PMID 15128738 DOI: 10.1074/jbc.M403541200 |
0.439 |
|
| 2003 |
Roitel O, Scrutton NS, Munro AW. Electron transfer in flavocytochrome P450 BM3: kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase. Biochemistry. 42: 10809-21. PMID 12962506 DOI: 10.1021/BI034562H |
0.345 |
|
| 2003 |
Gutierrez A, Munro AW, Grunau A, Wolf CR, Scrutton NS, Roberts GC. Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues. European Journal of Biochemistry / Febs. 270: 2612-21. PMID 12787027 DOI: 10.1046/J.1432-1033.2003.03633.X |
0.365 |
|
| 2003 |
Loechel C, Basran A, Basran J, Scrutton NS, Hall EA. Using trimethylamine dehydrogenase in an enzyme linked amperometric electrode. Part 1. Wild-type enzyme redox mediation. The Analyst. 128: 166-72. PMID 12625558 DOI: 10.1039/B211895E |
0.309 |
|
| 2003 |
McLean KJ, Scrutton NS, Munro AW. Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA. The Biochemical Journal. 372: 317-27. PMID 12614197 DOI: 10.1042/BJ20021692 |
0.351 |
|
| 2003 |
Knight K, Scrutton NS. Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase. The Biochemical Journal. 367: 19-30. PMID 12079493 DOI: 10.1042/BJ20020667 |
0.32 |
|
| 2002 |
Sutcliffe MJ, Scrutton NS. A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes. European Journal of Biochemistry. 269: 3096-102. PMID 12084049 DOI: 10.1046/J.1432-1033.2002.03020.X |
0.345 |
|
| 2002 |
Barna T, Messiha HL, Petosa C, Bruce NC, Scrutton NS, Moody PC. Crystal structure of bacterial morphinone reductase and properties of the C191A mutant enzyme. The Journal of Biological Chemistry. 277: 30976-83. PMID 12048188 DOI: 10.1074/JBC.M202846200 |
0.398 |
|
| 2002 |
Khan H, Harris RJ, Barna T, Craig DH, Bruce NC, Munro AW, Moody PC, Scrutton NS. Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters, and nitroaromatic explosives. The Journal of Biological Chemistry. 277: 21906-12. PMID 11923299 DOI: 10.1074/JBC.M200637200 |
0.399 |
|
| 2002 |
Williams RE, Rathbone DA, Moody PC, Scrutton NS, Bruce NC. Degradation of explosives by nitrate ester reductases. Biochemical Society Symposium. 143-53. PMID 11573344 DOI: 10.1042/BSS0680143 |
0.342 |
|
| 2001 |
Craig DH, Barna T, Moody PC, Bruce NC, Chapman SK, Munro AW, Scrutton NS. Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin. The Biochemical Journal. 359: 315-23. PMID 11583577 DOI: 10.1042/0264-6021:3590315 |
0.466 |
|
| 2001 |
Barna TM, Khan H, Bruce NC, Barsukov I, Scrutton NS, Moody PC. Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme. Journal of Molecular Biology. 310: 433-47. PMID 11428899 DOI: 10.1006/JMBI.2001.4779 |
0.365 |
|
| 2001 |
Meskys R, Harris RJ, Casaite V, Basran J, Scrutton NS. Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism. European Journal of Biochemistry. 268: 3390-8. PMID 11422368 DOI: 10.1046/J.1432-1327.2001.02239.X |
0.308 |
|
| 2000 |
Gutierrez A, Doehr O, Paine M, Wolf CR, Scrutton NS, Roberts GC. Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases. Biochemistry. 39: 15990-9. PMID 11123926 DOI: 10.1021/BI002135N |
0.399 |
|
| 2000 |
Harris RJ, Meskys R, Sutcliffe MJ, Scrutton NS. Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp. 1-IN. Biochemistry. 39: 1189-98. PMID 10684595 DOI: 10.1021/BI991941V |
0.334 |
|
| 1999 |
Trickey P, Basran J, Lian L, Chen Z, Barton J, Sutcliffe M, Scrutton N, Mathews F. Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from methylophilus methylotrophus (sp. W(3)A(1)). Biochemistry. 39: 7678-7688. PMID 10869173 DOI: 10.1021/Bi9927181 |
0.439 |
|
| 1999 |
Basran J, Sutcliffe MJ, Hille R, Scrutton NS. Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: Evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme-substrate complex Biochemical Journal. 341: 307-314. PMID 10393087 DOI: 10.1042/0264-6021:3410307 |
0.329 |
|
| 1999 |
Basran J, Jang MH, Sutcliffe MJ, Hille R, Scrutton NS. The role of Tyr-169 of trimethylamine dehydrogenase in substrate oxidation and magnetic interaction between FMN cofactor and the 4Fe/4S center Journal of Biological Chemistry. 274: 13155-13161. PMID 10224070 DOI: 10.1074/jbc.274.19.13155 |
0.337 |
|
| 1999 |
Jang MH, Basran J, Scrutton NS, Hille R. The reaction of trimethylamine dehydrogenase with trimethylamine Journal of Biological Chemistry. 274: 13147-13154. PMID 10224069 DOI: 10.1074/Jbc.274.19.13147 |
0.321 |
|
| 1999 |
Craig DH, Bruce NC, Moody PCE, Scrutton NS. Structure and mechanism of an opiate-transforming redox enzyme: morphinone reductase Biochemical Society Transactions. 27: A46-A46. DOI: 10.1042/Bst027A046B |
0.4 |
|
| 1998 |
Ertughrul OW, Errington N, Raza S, Sutcliffe MJ, Rowe AJ, Scrutton NS. Probing the stabilizing role of C-terminal residues in trimethylamine dehydrogenase. Protein Engineering. 11: 447-55. PMID 9725623 DOI: 10.1093/PROTEIN/11.6.447 |
0.371 |
|
| 1998 |
Craig DH, Moody PC, Bruce NC, Scrutton NS. Reductive and oxidative half-reactions of morphinone reductase from Pseudomonas putida M10: a kinetic and thermodynamic analysis. Biochemistry. 37: 7598-607. PMID 9585575 DOI: 10.1021/BI980345I |
0.316 |
|
| 1997 |
Mewies M, Basran J, Packman LC, Hille R, Scrutton NS. Involvement of a flavin iminoquinone methide in the formation of 6-hydroxyflavin mononucleotide in trimethylamine dehydrogenase: a rationale for the existence of 8alpha-methyl and C6-linked covalent flavoproteins. Biochemistry. 36: 7162-8. PMID 9188716 DOI: 10.1021/Bi970621D |
0.382 |
|
| 1997 |
Basran J, Mewies M, Mathews FS, Scrutton NS. Selective modification of alkylammonium ion specificity in trimethylamine dehydrogenase by the rational engineering of cation-pi bonding. Biochemistry. 36: 1989-98. PMID 9047296 DOI: 10.1021/BI962623O |
0.407 |
|
| 1997 |
Wilson EK, Huang L, Sutcliffe MJ, Mathews FS, Hille R, Scrutton NS. An exposed tyrosine on the surface of trimethylamine dehydrogenase facilitates electron transfer to electron transferring flavoprotein: Kinetics of transfer in wild-type and mutant complexes Biochemistry. 36: 41-48. PMID 8993316 DOI: 10.1021/Bi961224Q |
0.393 |
|
| 1996 |
Mewies M, Packman LC, Mathews FS, Scrutton NS. Flavinylation in wild-type trimethylamine dehydrogenase and differentially charged mutant enzymes: a study of the protein environment around the N1 of the flavin isoalloxazine. The Biochemical Journal. 267-72. PMID 8694773 DOI: 10.1042/BJ3170267 |
0.391 |
|
| 1996 |
Huang L, Scrutton NS, Hille R. Reaction of the C30A mutant of trimethylamine dehydrogenase with diethylmethylamine. The Journal of Biological Chemistry. 271: 13401-6. PMID 8662829 DOI: 10.1074/Jbc.271.23.13401 |
0.327 |
|
| 1995 |
Bashir A, Perham RN, Scrutton NS, Berry A. Altering kinetic mechanism and enzyme stability by mutagenesis of the dimer interface of glutathione reductase. The Biochemical Journal. 312: 527-33. PMID 8526866 |
0.734 |
|
| 1995 |
Packman LC, Mewies M, Scrutton NS. The flavinylation reaction of trimethylamine dehydrogenase. Analysis by directed mutagenesis and electrospray mass spectrometry. The Journal of Biological Chemistry. 270: 13186-91. PMID 7768915 DOI: 10.1074/JBC.270.22.13186 |
0.424 |
|
| 1995 |
Yang CC, Packman LC, Scrutton NS. The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition. European Journal of Biochemistry. 232: 264-71. PMID 7556160 DOI: 10.1111/J.1432-1033.1995.TB20808.X |
0.301 |
|
| 1994 |
Mittl PR, Berry A, Scrutton NS, Perham RN, Schultz GE. A designed mutant of the enzyme glutathione reductase shortens the crystallization time by a factor of forty. Acta Crystallographica. Section D, Biological Crystallography. 50: 228-31. PMID 15299464 DOI: 10.1107/S090744499300993X |
0.666 |
|
| 1994 |
Rietveld P, Arscott LD, Berry A, Scrutton NS, Deonarain MP, Perham RN, Williams CH. Reductive and oxidative half-reactions of glutathione reductase from Escherichia coli. Biochemistry. 33: 13888-95. PMID 7947797 DOI: 10.1021/Bi00250A043 |
0.715 |
|
| 1994 |
Raine AR, Scrutton NS, Mathews FS. On the evolution of alternate core packing in eightfold beta/alpha-barrels. Protein Science : a Publication of the Protein Society. 3: 1889-92. PMID 7849604 DOI: 10.1002/Pro.5560031028 |
0.34 |
|
| 1994 |
Mittl PR, Berry A, Scrutton NS, Perham RN, Schulz GE. Anatomy of an engineered NAD-binding site. Protein Science : a Publication of the Protein Society. 3: 1504-14. PMID 7833810 DOI: 10.1002/pro.5560030916 |
0.725 |
|
| 1993 |
Mittl PR, Berry A, Scrutton NS, Perham RN, Schulz GE. Structural differences between wild-type NADP-dependent glutathione reductase from Escherichia coli and a redesigned NAD-dependent mutant. Journal of Molecular Biology. 231: 191-5. PMID 8510142 DOI: 10.1006/jmbi.1993.1274 |
0.731 |
|
| 1993 |
Bocanegra JA, Scrutton NS, Perham RN. Creation of an NADP-dependent pyruvate dehydrogenase multienzyme complex by protein engineering. Biochemistry. 32: 2737-40. PMID 8457541 |
0.608 |
|
| 1992 |
Deonarain MP, Scrutton NS, Perham RN. Engineering surface charge. 2. A method for purifying heterodimers of Escherichia coli glutathione reductase. Biochemistry. 31: 1498-504. PMID 1737009 |
0.619 |
|
| 1992 |
Deonarain MP, Scrutton NS, Perham RN. Engineering surface charge. 1. A method for detecting subunit exchange in Escherichia coli glutathione reductase. Biochemistry. 31: 1491-7. PMID 1737008 |
0.61 |
|
| 1992 |
Scrutton NS, Deonarain MP, Berry A, Perham RN. Cooperativity induced by a single mutation at the subunit interface of a dimeric enzyme: glutathione reductase. Science (New York, N.Y.). 258: 1140-3. PMID 1439821 |
0.726 |
|
| 1991 |
Henderson GB, Murgolo NJ, Kuriyan J, Osapay K, Kominos D, Berry A, Scrutton NS, Hinchliffe NW, Perham RN, Cerami A. Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Proceedings of the National Academy of Sciences of the United States of America. 88: 8769-73. PMID 1924337 DOI: 10.1073/Pnas.88.19.8769 |
0.741 |
|
| 1991 |
Perham RN, Scrutton NS, Berry A. New enzymes for old: redesigning the coenzyme and substrate specificities of glutathione reductase. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 13: 515-25. PMID 1755827 DOI: 10.1002/bies.950131005 |
0.745 |
|
| 1990 |
Scrutton NS, Berry A, Perham RN. Redesign of the coenzyme specificity of a dehydrogenase by protein engineering. Nature. 343: 38-43. PMID 2296288 DOI: 10.1038/343038a0 |
0.727 |
|
| 1990 |
Scrutton NS, Berry A, Deonarain MP, Perham RN. Active site complementation in engineered heterodimers of Escherichia coli glutathione reductase created in vivo. Proceedings. Biological Sciences / the Royal Society. 242: 217-24. PMID 1983037 DOI: 10.1098/rspb.1990.0127 |
0.738 |
|
| 1990 |
Deonarain MP, Scrutton NS, Berry A, Perham RN. Directed mutagenesis of the redox-active disulphide bridge in glutathione reductase from Escherichia coli. Proceedings. Biological Sciences / the Royal Society. 241: 179-86. PMID 1979442 DOI: 10.1098/rspb.1990.0083 |
0.738 |
|
| 1989 |
Deonarain MP, Berry A, Scrutton NS, Perham RN. Alternative proton donors/acceptors in the catalytic mechanism of the glutathione reductase of Escherichia coli: the role of histidine-439 and tyrosine-99. Biochemistry. 28: 9602-7. PMID 2558727 DOI: 10.1021/bi00451a008 |
0.735 |
|
| 1989 |
Berry A, Scrutton NS, Perham RN. Switching kinetic mechanism and putative proton donor by directed mutagenesis of glutathione reductase. Biochemistry. 28: 1264-9. PMID 2540822 |
0.747 |
|
| 1988 |
Perham RN, Berry A, Scrutton NS. Flavoprotein disulphide oxidoreductases: protein engineering of glutathione reductase from Escherichia coli. Biochemical Society Transactions. 16: 84-7. PMID 3286318 |
0.664 |
|
| 1988 |
Scrutton NS, Berry A, Perham RN. Engineering of an intersubunit disulphide bridge in glutathione reductase from Escherichia coli. Febs Letters. 241: 46-50. PMID 3058515 DOI: 10.1016/0014-5793(88)81028-7 |
0.748 |
|
| 1987 |
Scrutton NS, Berry A, Perham RN. Purification and characterization of glutathione reductase encoded by a cloned and over-expressed gene in Escherichia coli. The Biochemical Journal. 245: 875-80. PMID 3311037 |
0.701 |
|
| 1986 |
Scrutton NS, Berry A, Perham RN. Protein engineering of glutathione reductase: Over-expression of the gene from Escherichia coli Biochemical Society Transactions. 14: 1229-1230. |
0.653 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2015 |
Hernández-Ortega A, Quesne MG, Bui S, Heyes DJ, Steiner RA, Scrutton NS, de Visser SP. Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates. Journal of the American Chemical Society. 137: 7474-87. PMID 25988744 DOI: 10.1021/Jacs.5B03836 |
0.3 |
|
| 2020 |
Toogood HS, Scrutton NS. Thermal, electrochemical and photochemical reactions involving catalytically versatile ene reductase enzymes. The Enzymes. 47: 491-515. PMID 32951833 DOI: 10.1016/bs.enz.2020.05.012 |
0.3 |
|
| 2006 |
Sutcliffe MJ, Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Leys D, Scrutton NS. Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 361: 1375-86. PMID 16873125 DOI: 10.1098/rstb.2006.1878 |
0.297 |
|
| 2016 |
Ortmayer M, Lafite P, Menon BR, Tralau T, Fisher K, Denkhaus L, Scrutton NS, Rigby SE, Munro AW, Hay S, Leys D. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme. Nature. PMID 27851736 DOI: 10.1038/Nature20159 |
0.294 |
|
| 2001 |
Basran J, Sutcliffe MJ, Scrutton NS. Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes. The Journal of Biological Chemistry. 276: 24581-7. PMID 11304539 DOI: 10.1074/jbc.M101178200 |
0.293 |
|
| 2013 |
Fraaije MW, Scrutton NS. Special issue: Catalytic mechanisms by biological systems--introduction. The Febs Journal. 280: 2947. PMID 23648083 DOI: 10.1111/febs.12317 |
0.293 |
|
| 2007 |
Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS. Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry. 46: 11833-44. PMID 17892308 DOI: 10.1021/BI701209P |
0.293 |
|
| 2023 |
Kearsey LJ, Yan C, Prandi N, Toogood HS, Takano E, Scrutton NS. Biosynthesis of cannabigerol and cannabigerolic acid: the gateways to further cannabinoid production. Synthetic Biology (Oxford, England). 8: ysad010. PMID 37323510 DOI: 10.1093/synbio/ysad010 |
0.292 |
|
| 2021 |
Ferraz CA, Leferink NGH, Kosov I, Scrutton N. Isopentenol utilization pathway for the production of linalool in Escherichia coli using an improved bacterial linalool/nerolidol synthase. Chembiochem : a European Journal of Chemical Biology. PMID 33938632 DOI: 10.1002/cbic.202100110 |
0.292 |
|
| 2007 |
Ranaghan KE, Masgrau L, Scrutton NS, Sutcliffe MJ, Mulholland AJ. Analysis of classical and quantum paths for deprotonation of methylamine by methylamine dehydrogenase. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 8: 1816-35. PMID 17676581 DOI: 10.1002/CPHC.200700143 |
0.292 |
|
| 2003 |
Leys D, Basran J, Scrutton NS. Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase. The Embo Journal. 22: 4038-48. PMID 12912903 DOI: 10.1093/emboj/cdg395 |
0.292 |
|
| 2012 |
Pang J, Li X, Morokuma K, Scrutton NS, Sutcliffe MJ. Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study. Journal of the American Chemical Society. 134: 2367-77. PMID 22239442 DOI: 10.1021/Ja210417K |
0.291 |
|
| 2003 |
Loechel C, Basran A, Basran J, Scrutton NS, Hall EAH. Using trimethylamine dehydrogenase in an enzyme linked amperometric electrode Analyst. 128: 889-898. DOI: 10.1039/B302298F |
0.291 |
|
| 2015 |
Hedison TM, Hay S, Scrutton NS. Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c. The Febs Journal. 282: 4357-75. PMID 26307151 DOI: 10.1111/febs.13501 |
0.291 |
|
| 2016 |
Christianson DW, Scrutton NS. Editorial overview: Catalysis and regulation: enzyme structure, mechanism, and biosynthetic pathways. Current Opinion in Structural Biology. PMID 27646478 DOI: 10.1016/J.Sbi.2016.09.005 |
0.291 |
|
| 2000 |
Scrutton NS. Colworth Medal Lecture. Enzymes in the quantum world. Biochemical Society Transactions. 27: 767-79. PMID 10830100 DOI: 10.1042/BST0270767 |
0.289 |
|
| 2008 |
Neeli R, Sabri M, McLean KJ, Dunford AJ, Scrutton NS, Leys D, Munro AW. Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA. The Biochemical Journal. 411: 563-70. PMID 18237273 DOI: 10.1042/bj20071298 |
0.289 |
|
| 2022 |
Rose SL, Baba S, Okumura H, Antonyuk SV, Sasaki D, Hedison TM, Shanmugam M, Heyes DJ, Scrutton NS, Kumasaka T, Tosha T, Eady RR, Yamamoto M, Hasnain SS. Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205664119. PMID 35862453 DOI: 10.1073/pnas.2205664119 |
0.289 |
|
| 2013 |
Pudney CR, Lane RS, Fielding AJ, Magennis SW, Hay S, Scrutton NS. Enzymatic single-molecule kinetic isotope effects. Journal of the American Chemical Society. 135: 3855-64. PMID 23402437 DOI: 10.1021/ja309286r |
0.288 |
|
| 1994 |
Scrutton N, Packman L, Mathews F, Rohlfs R, Hille R. Assembly of redox centers in the trimethylamine dehydrogenase of bacterium W3A1. Properties of the wild-type enzyme and a C30A mutant expressed from a cloned gene in Escherichia coli. Journal of Biological Chemistry. 269: 13942-13950. DOI: 10.1016/s0021-9258(17)36739-x |
0.288 |
|
| 2014 |
Menon BR, Fisher K, Rigby SE, Scrutton NS, Leys D. A conformational sampling model for radical catalysis in pyridoxal phosphate- and cobalamin-dependent enzymes. The Journal of Biological Chemistry. 289: 34161-74. PMID 25213862 DOI: 10.1074/Jbc.M114.590471 |
0.288 |
|
| 2019 |
Czarnota S, Johannissen LO, Baxter NJ, Rummel F, Wilson AL, Cliff MJ, Levy CW, Scrutton NS, Waltho JP, Hay S. Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol--methyltransferase. Acs Catalysis. 9: 4394-4401. PMID 31080692 DOI: 10.1021/Acscatal.9B00174 |
0.288 |
|
| 2002 |
Lad L, Mewies M, Raven E, Basran J, Scrutton N. Role of histidine 42 in ascorbate peroxidase: Kinetic analysis of the H42A and H42E variants Scopus. 269: 3182-92. PMID 12084058 DOI: 10.1046/J.1432-1033.2002.02998.X |
0.287 |
|
| 2023 |
Speirs M, Hardman SJO, Iorgu AI, Johannissen LO, Heyes DJ, Scrutton NS, Sazanovich IV, Hay S. Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analogue to Oxidized Flavin in an Ene-Reductase Flavoenzyme. The Journal of Physical Chemistry Letters. 3236-3242. PMID 36972502 DOI: 10.1021/acs.jpclett.3c00176 |
0.287 |
|
| 2000 |
Sutcliffe MJ, Scrutton NS. Enzyme catalysis: over-the-barrier or through-the-barrier? Trends in Biochemical Sciences. 25: 405-8. PMID 10973049 DOI: 10.1016/S0968-0004(00)01642-X |
0.286 |
|
| 2010 |
Hay S, Johannissen LO, Sutcliffe MJ, Scrutton NS. Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis. Biophysical Journal. 98: 121-8. PMID 20085724 DOI: 10.1016/j.bpj.2009.09.045 |
0.286 |
|
| 2007 |
Masgrau L, Ranaghan KE, Scrutton NS, Mulholland AJ, Sutcliffe MJ. Tunneling and classical paths for proton transfer in an enzyme reaction dominated by tunneling: oxidation of tryptamine by aromatic amine dehydrogenase. The Journal of Physical Chemistry. B. 111: 3032-47. PMID 17388439 DOI: 10.1021/JP067898K |
0.285 |
|
| 2021 |
Messiha HL, Payne KAP, Scrutton NS, Leys D. A Biological Route to Conjugated Alkenes: Microbial Production of Hepta-1,3,5-triene. Acs Synthetic Biology. PMID 33535752 DOI: 10.1021/acssynbio.0c00464 |
0.284 |
|
| 2017 |
Gahloth D, Dunstan MS, Quaglia D, Klumbys E, Lockhart-Cairns MP, Hill AM, Derrington SR, Scrutton NS, Turner NJ, Leys D. Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis. Nature Chemical Biology. PMID 28719588 DOI: 10.1038/nchembio.2434 |
0.283 |
|
| 2011 |
Pudney CR, Khara B, Johannissen LO, Scrutton NS. Coupled motions direct electrons along human microsomal P450 Chains. Plos Biology. 9: e1001222. PMID 22205878 DOI: 10.1371/journal.pbio.1001222 |
0.283 |
|
| 2020 |
Reddy GK, Leferink NGH, Umemura M, Ahmed ST, Breitling R, Scrutton NS, Takano E. Exploring novel bacterial terpene synthases. Plos One. 15: e0232220. PMID 32353014 DOI: 10.1371/journal.pone.0232220 |
0.283 |
|
| 2009 |
Hay S, Pudney CR, Scrutton NS. Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling. The Febs Journal. 276: 3930-41. PMID 19583766 DOI: 10.1111/j.1742-4658.2009.07121.x |
0.283 |
|
| 2015 |
Leferink NG, Hay S, Rigby SE, Scrutton NS. Towards the free energy landscape for catalysis in mammalian nitric oxide synthases. The Febs Journal. 282: 3016-29. PMID 25491181 DOI: 10.1111/febs.13171 |
0.283 |
|
| 2008 |
Wolthers KR, Rigby SE, Scrutton NS. Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4,5-aminomutase. The Journal of Biological Chemistry. 283: 34615-25. PMID 18948256 DOI: 10.1074/jbc.M807911200 |
0.283 |
|
| 2017 |
Heyes DJ, Hardman SJ, Mansell D, Ní Cheallaigh A, Gardiner JM, Johannissen LO, Greetham GM, Towrie M, Scrutton NS. Excited State Properties of Protochlorophyllide Analogues and the Implications for Light Driven Synthesis of Chlorophyll. The Journal of Physical Chemistry. B. PMID 28117585 DOI: 10.1021/Acs.Jpcb.7B00528 |
0.282 |
|
| 2018 |
Iorgu AI, Baxter NJ, Cliff MJ, Levy C, Waltho JP, Hay S, Scrutton NS. Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes. Acs Catalysis. 8: 11589-11599. PMID 31119061 DOI: 10.1021/Acscatal.8B02810 |
0.282 |
|
| 2015 |
Menon BR, Menon N, Fisher K, Rigby SE, Leys D, Scrutton NS. Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase. The Febs Journal. 282: 1242-55. PMID 25627283 DOI: 10.1111/Febs.13215 |
0.281 |
|
| 2011 |
Leferink NG, Han C, Antonyuk SV, Heyes DJ, Rigby SE, Hough MA, Eady RR, Scrutton NS, Hasnain SS. Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase. Biochemistry. 50: 4121-31. PMID 21469743 DOI: 10.1021/bi200246f |
0.281 |
|
| 2002 |
Basran J, Bhanji N, Basran A, Nietlispach D, Mistry S, Meskys R, Scrutton NS. Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry. Biochemistry. 41: 4733-43. PMID 11926836 DOI: 10.1021/BI025519H |
0.281 |
|
| 2017 |
Iorgu AI, Baxter NJ, Cliff MJ, Waltho JP, Hay S, Scrutton NS. (1)H, (15)N and (13)C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2. Biomolecular Nmr Assignments. PMID 29168057 DOI: 10.1007/S12104-017-9791-2 |
0.281 |
|
| 2014 |
Hardman SJ, Pudney CR, Hay S, Scrutton NS. Excited state dynamics can be used to probe donor-acceptor distances for H-tunneling reactions catalyzed by flavoproteins. Biophysical Journal. 105: 2549-58. PMID 24314085 DOI: 10.1016/j.bpj.2013.10.015 |
0.28 |
|
| 2012 |
Heyes DJ, Hardman SJ, Mansell D, Gardiner JM, Scrutton NS. Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase. Plos One. 7: e45642. PMID 23049830 DOI: 10.1371/Journal.Pone.0045642 |
0.28 |
|
| 2001 |
Basran J, Sutcliffe MJ, Scrutton NS. Optimizing the Michaelis complex of trimethylamine dehydrogenase: identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base. The Journal of Biological Chemistry. 276: 42887-92. PMID 11553643 DOI: 10.1074/jbc.M108296200 |
0.28 |
|
| 2003 |
Gutierrez A, Grunau A, Paine M, Munro AW, Wolf CR, Roberts GC, Scrutton NS. Electron transfer in human cytochrome P450 reductase. Biochemical Society Transactions. 31: 497-501. PMID 12773143 DOI: 10.1042/BST0310497 |
0.279 |
|
| 2017 |
Ranaghan KE, Morris WG, Masgrau L, Senthilkumar K, Johannissen LO, Scrutton NS, Harvey JN, Manby FR, Mulholland AJ. Ab Initio QM/MM Modelling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase. The Journal of Physical Chemistry. B. PMID 28930453 DOI: 10.1021/Acs.Jpcb.7B06892 |
0.278 |
|
| 2004 |
Wolthers KR, Scrutton NS. Electron transfer in human methionine synthase reductase studied by stopped-flow spectrophotometry. Biochemistry. 43: 490-500. PMID 14717604 DOI: 10.1021/BI0356303 |
0.278 |
|
| 1988 |
Singh M, Scrutton NS, Scrutton MC. NADPH generation in Aspergillus nidulans: is the mannitol cycle involved? Journal of General Microbiology. 134: 643-54. PMID 3141571 DOI: 10.1099/00221287-134-3-643 |
0.277 |
|
| 2009 |
Heyes DJ, Sakuma M, de Visser SP, Scrutton NS. Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase Journal of Biological Chemistry. 284: 3762-3767. PMID 19073603 DOI: 10.1074/jbc.M808548200 |
0.276 |
|
| 2005 |
Hothi P, Khadra KA, Combe JP, Leys D, Scrutton NS. Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis. Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans. The Febs Journal. 272: 5894-909. PMID 16279953 DOI: 10.1111/j.1742-4658.2005.04990.x |
0.276 |
|
| 2007 |
Wolthers KR, Toogood HS, Jowitt TA, Marshall KR, Leys D, Scrutton NS. Crystal structure and solution characterization of the activation domain of human methionine synthase Febs Journal. 274: 738-750. PMID 17288554 DOI: 10.1111/j.1742-4658.2006.05618.x |
0.275 |
|
| 2009 |
Johannissen LO, Scrutton NS, Sutcliffe MJ. The enzyme aromatic amine dehydrogenase induces a substrate conformation crucial for promoting vibration that significantly reduces the effective potential energy barrier to proton transfer. Journal of the Royal Society, Interface. S225-32. PMID 18495615 DOI: 10.1098/rsif.2008.0068.focus |
0.272 |
|
| 2015 |
White MD, Payne KA, Fisher K, Marshall SA, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Rigby SE, Scrutton NS, Hay S, Leys D. UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis. Nature. 522: 502-6. PMID 26083743 DOI: 10.1038/Nature14559 |
0.272 |
|
| 2014 |
Sobolewska-Stawiarz A, Leferink NG, Fisher K, Heyes DJ, Hay S, Rigby SE, Scrutton NS. Energy landscapes and catalysis in nitric-oxide synthase. The Journal of Biological Chemistry. 289: 11725-38. PMID 24610812 DOI: 10.1074/Jbc.M114.548834 |
0.271 |
|
| 2007 |
Miseviciene L, Anusevicius Z, Sarlauskas J, Harris RJ, Scrutton NS, Cenas N. Two-electron reduction of quinones by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships. Acta Biochimica Polonica. 54: 379-385. DOI: 10.18388/ABP.2007_3260 |
0.271 |
|
| 2009 |
Tralau T, Lafite P, Levy C, Combe JP, Scrutton NS, Leys D. An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde. The Journal of Biological Chemistry. 284: 17826-34. PMID 19369258 DOI: 10.1074/jbc.M109.006262 |
0.27 |
|
| 2009 |
Dunford AJ, Girvan HM, Scrutton NS, Munro AW. Probing the molecular determinants of coenzyme selectivity in the P450 BM3 FAD/NADPH domain. Biochimica Et Biophysica Acta. 1794: 1181-9. PMID 19344791 DOI: 10.1016/j.bbapap.2009.03.014 |
0.27 |
|
| 2003 |
Hothi P, Basran J, Sutcliffe MJ, Scrutton NS. Effects of multiple ligand binding on kinetic isotope effects in PQQ-dependent methanol dehydrogenase. Biochemistry. 42: 3966-78. PMID 12667088 DOI: 10.1021/BI027282V |
0.269 |
|
| 2020 |
Zhang S, Godwin ARF, Taylor A, Hardman SJO, Jowitt TA, Johannissen LO, Hay S, Baldock C, Heyes DJ, Scrutton NS. Dual Role of the Active Site 'Lid' Regions of Protochlorophyllide Oxidoreductase in Photocatalysis and Plant Development. The Febs Journal. PMID 32866986 DOI: 10.1111/febs.15542 |
0.269 |
|
| 2018 |
Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL, Stegle O. Selenzyme: Enzyme selection tool for pathway design. Bioinformatics (Oxford, England). PMID 29425325 DOI: 10.1093/bioinformatics/bty065 |
0.268 |
|
| 2022 |
Liu M, Ma W, Su X, Zhang X, Lu Y, Zhang S, Yan J, Feng D, Ma L, Taylor A, Ge Y, Cheng Q, Xu K, Wang Y, Li N, ... ... Scrutton NS, et al. Mutation in a chlorophyll-binding motif of Brassica ferrochelatase enhances both heme and chlorophyll biosynthesis. Cell Reports. 41: 111758. PMID 36476857 DOI: 10.1016/j.celrep.2022.111758 |
0.268 |
|
| 2008 |
Hothi P, Hay S, Roujeinikova A, Sutcliffe MJ, Lee M, Leys D, Cullis PM, Scrutton NS. Driving Force Analysis of Proton Tunnelling Across a Reactivity Series for an Enzyme-Substrate Complex Chembiochem. 9: 2839-2845. PMID 19012287 DOI: 10.1002/Cbic.200800408 |
0.267 |
|
| 2008 |
Hay S, Pudney C, Hothi P, Johannissen LO, Masgrau L, Pang J, Leys D, Sutcliffe MJ, Scrutton NS. Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation. Biochemical Society Transactions. 36: 16-21. PMID 18208377 DOI: 10.1042/BST0360016 |
0.267 |
|
| 2005 |
Scrutton NS. Chemical Aspects of Amine Oxidation by Flavoprotein Enzymes Cheminform. 36. DOI: 10.1002/CHIN.200514280 |
0.267 |
|
| 2006 |
Scrutton NS, Sutcliffe MJ, Dutton PL. Quantum catalysis in enzymes: beyond the transition state theory paradigm. A Discussion Meeting held at the Royal Society on 14 and 15 November 2005 Journal of the Royal Society Interface. 3: 465-469. PMID 16849275 DOI: 10.1098/Rsif.2006.0122 |
0.267 |
|
| 2014 |
Wongnate T, Surawatanawong P, Visitsatthawong S, Sucharitakul J, Scrutton NS, Chaiyen P. Proton-coupled electron transfer and adduct configuration are important for C4a-hydroperoxyflavin formation and stabilization in a flavoenzyme. Journal of the American Chemical Society. 136: 241-53. PMID 24368083 DOI: 10.1021/Ja4088055 |
0.266 |
|
| 2015 |
Jones AR, Rentergent J, Scrutton NS, Hay S. Probing reversible chemistry in coenzyme B12 -dependent ethanolamine ammonia lyase with kinetic isotope effects. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 8826-31. PMID 25950663 DOI: 10.1002/chem.201500958 |
0.265 |
|
| 2007 |
Dunford AJ, Rigby SE, Hay S, Munro AW, Scrutton NS. Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase. Biochemistry. 46: 5018-29. PMID 17411075 DOI: 10.1021/BI7001339 |
0.264 |
|
| 2013 |
Toogood HS, Scrutton NS. Enzyme engineering toolbox – a ‘catalyst’ for change Catalysis Science & Technology. 3: 2182. DOI: 10.1039/C3CY00202K |
0.264 |
|
| 2011 |
Bowsher CG, Eyres LM, Gummadova JO, Hothi P, McLean KJ, Munro AW, Scrutton NS, Hanke GT, Sakakibara Y, Hase T. Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interactions with ferredoxin. Biochemistry. 50: 1778-87. PMID 21265508 DOI: 10.1021/bi1014562 |
0.263 |
|
| 2021 |
Rinaldi MA, Ferraz CA, Scrutton NS. Alternative metabolic pathways and strategies to high-titre terpenoid production in . Natural Product Reports. PMID 34231643 DOI: 10.1039/d1np00025j |
0.263 |
|
| 2017 |
Scrutton NS. Enzymes make light work of hydrocarbon production. Science (New York, N.Y.). 357: 872-873. PMID 28860372 DOI: 10.1126/science.aao4399 |
0.262 |
|
| 2012 |
Fryszkowska A, Toogood HS, Mansell D, Stephens G, Gardiner JM, Scrutton NS. A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction. The Febs Journal. 279: 4160-71. PMID 22978386 DOI: 10.1111/Febs.12008 |
0.262 |
|
| 2020 |
Breslmayr E, Laurent CVFP, Scheiblbrandner S, Jerkovic A, Heyes DJ, Oostenbrink C, Ludwig R, Hedison TM, Scrutton NS, Kracher D. Protein Conformational Change Is Essential for Reductive Activation of Lytic Polysaccharide Monooxygenase by Cellobiose Dehydrogenase. Acs Catalysis. 10: 4842-4853. PMID 32382450 DOI: 10.1021/Acscatal.0C00754 |
0.261 |
|
| 2004 |
Dunford AJ, Marshall KR, Munro AW, Scrutton NS. Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395 European Journal of Biochemistry. 271: 2548-2560. PMID 15182370 DOI: 10.1111/j.1432-1033.2004.04185.x |
0.261 |
|
| 1999 |
Scrutton NS, Basran J, Sutcliffe MJ. New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics. European Journal of Biochemistry. 264: 666-71. PMID 10491112 DOI: 10.1046/J.1432-1327.1999.00645.X |
0.26 |
|
| 1998 |
Mewies M, McIntire WS, Scrutton NS. Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs. Protein Science : a Publication of the Protein Society. 7: 7-20. PMID 9514256 DOI: 10.1002/PRO.5560070102 |
0.259 |
|
| 2008 |
Toogood HS, Fryszkowska A, Hare V, Fisher K, Roujeinikova A, Leys D, Gardiner JM, Stephens GM, Scrutton NS. Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase. Advanced Synthesis & Catalysis. 350: 2789-2803. PMID 20396603 DOI: 10.1002/Adsc.200800561 |
0.259 |
|
| 2009 |
Fryszkowska A, Toogood H, Sakuma M, Gardiner JM, Stephens GM, Scrutton NS. Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation. Advanced Synthesis & Catalysis. 351: 2976-2990. PMID 20396613 DOI: 10.1002/Adsc.200900574 |
0.259 |
|
| 2012 |
Hay S, Johannissen LO, Hothi P, Sutcliffe MJ, Scrutton NS. Pressure effects on enzyme-catalyzed quantum tunneling events arise from protein-specific structural and dynamic changes. Journal of the American Chemical Society. 134: 9749-54. PMID 22632111 DOI: 10.1021/ja3024115 |
0.258 |
|
| 2007 |
Roujeinikova A, Hothi P, Masgrau L, Sutcliffe MJ, Scrutton NS, Leys D. New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates. The Journal of Biological Chemistry. 282: 23766-77. PMID 17475620 DOI: 10.1074/jbc.M700677200 |
0.258 |
|
| 2012 |
Leferink NG, Pudney CR, Brenner S, Heyes DJ, Eady RR, Samar Hasnain S, Hay S, Rigby SE, Scrutton NS. Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase. Febs Letters. 586: 578-84. PMID 21762695 DOI: 10.1016/j.febslet.2011.07.003 |
0.258 |
|
| 2008 |
Hay S, Scrutton NS. H-transfers in Photosystem II: what can we learn from recent lessons in the enzyme community? Photosynthesis Research. 98: 169-77. PMID 18766465 DOI: 10.1007/s11120-008-9326-x |
0.257 |
|
| 2017 |
Scrutton NS. Speeding up enzyme engineering computationally. Iucrj. 4: 5-6. PMID 28250937 DOI: 10.1107/S2052252516019692 |
0.257 |
|
| 2011 |
Hay S, Scrutton NS. Examining the importance of dynamics, barrier compression and hydrogen tunnelling in enzyme catalysed reactions Procedia Chemistry. 3: 306-315. DOI: 10.1016/J.PROCHE.2011.08.038 |
0.256 |
|
| 2007 |
Heyes DJ, Sakuma M, Scrutton NS. Laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase. The Journal of Biological Chemistry. 282: 32015-20. PMID 17848549 DOI: 10.1074/jbc.M706098200 |
0.255 |
|
| 2012 |
Pudney CR, Heyes DJ, Khara B, Hay S, Rigby SE, Scrutton NS. Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes. The Febs Journal. 279: 1534-44. PMID 22142452 DOI: 10.1111/j.1742-4658.2011.08442.x |
0.255 |
|
| 2001 |
Talfournier F, Munro AW, Basran J, Sutcliffe MJ, Daff S, Chapman SK, Scrutton NS. alpha Arg-237 in Methylophilus methylotrophus (sp. W3A1) electron-transferring flavoprotein affords approximately 200-millivolt stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone. The Journal of Biological Chemistry. 276: 20190-6. PMID 11285259 DOI: 10.1074/jbc.M010853200 |
0.254 |
|
| 2006 |
Roujeinikova A, Scrutton NS, Leys D. Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase. The Journal of Biological Chemistry. 281: 40264-72. PMID 17005560 DOI: 10.1074/jbc.M605559200 |
0.253 |
|
| 2016 |
Beveridge R, Migas LG, Payne KA, Scrutton NS, Leys D, Barran PE. Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding. Nature Communications. 7: 12163. PMID 27418477 DOI: 10.1038/Ncomms12163 |
0.252 |
|
| 2007 |
Brenner S, Hay S, Girvan HM, Munro AW, Scrutton NS. Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy. The Journal of Physical Chemistry. B. 111: 7879-86. PMID 17571881 DOI: 10.1021/jp073036n |
0.252 |
|
| 2020 |
Hedison TM, Shanmugam M, Heyes DJ, Edge R, Scrutton NS. Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping-Electron Paramagnetic Resonance Approach. Angewandte Chemie (International Ed. in English). 59: 13936-13940. PMID 32352195 DOI: 10.1002/anie.202005052 |
0.252 |
|
| 2005 |
McLean KJ, Sabri M, Marshall KR, Lawson RJ, Lewis DG, Clift D, Balding PR, Dunford AJ, Warman AJ, McVey JP, Quinn AM, Sutcliffe MJ, Scrutton NS, Munro AW. Biodiversity of cytochrome P450 redox systems. Biochemical Society Transactions. 33: 796-801. PMID 16042601 DOI: 10.1042/BST0330796 |
0.251 |
|
| 2020 |
Amer M, Toogood H, Scrutton NS. Engineering nature for gaseous hydrocarbon production. Microbial Cell Factories. 19: 209. PMID 33187524 DOI: 10.1186/s12934-020-01470-6 |
0.251 |
|
| 2009 |
Sabri M, Dunford AJ, McLean KJ, Neeli R, Scrutton NS, Leys D, Munro AW. Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site. The Biochemical Journal. 417: 103-12. PMID 18767989 DOI: 10.1042/BJ20080466 |
0.251 |
|
| 2006 |
Girvan HM, Waltham TN, Neeli R, Collins HF, McLean KJ, Scrutton NS, Leys D, Munro AW. Flavocytochrome P450 BM3 and the origin of CYP102 fusion species. Biochemical Society Transactions. 34: 1173-7. PMID 17073779 DOI: 10.1042/BST0341173 |
0.25 |
|
| 2006 |
Dutton PL, Munro AW, Scrutton NS, Sutcliffe MJ. Introduction. Quantum catalysis in enzymes: beyond the transition state theory paradigm Philosophical Transactions of the Royal Society B: Biological Sciences. 361: 1293-1294. DOI: 10.1098/Rstb.2006.1879 |
0.249 |
|
| 2005 |
Toogood HS, van Thiel A, Scrutton NS, Leys D. Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein. The Journal of Biological Chemistry. 280: 30361-6. PMID 15975918 DOI: 10.1074/jbc.M505562200 |
0.249 |
|
| 2014 |
Hickling C, Toogood HS, Saiani A, Scrutton NS, Miller AF. Nanofibrillar Peptide hydrogels for the immobilization of biocatalysts for chemical transformations. Macromolecular Rapid Communications. 35: 868-74. PMID 24604676 DOI: 10.1002/marc.201400027 |
0.248 |
|
| 2007 |
Pudney CR, Hay S, Sutcliffe MJ, Scrutton NS. Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models. Journal of the American Chemical Society. 128: 14053-8. PMID 17061887 DOI: 10.1021/JA0614619 |
0.248 |
|
| 2001 |
Gutierrez A, Lian LY, Wolf CR, Scrutton NS, Roberts GC. Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains. Biochemistry. 40: 1964-75. PMID 11329263 DOI: 10.1021/BI001719M |
0.248 |
|
| 2019 |
Toogood HS, Scrutton NS. Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis. Acs Catalysis. 8: 3532-3549. PMID 31157123 DOI: 10.1021/acscatal.8b00624 |
0.248 |
|
| 2001 |
Wilson EK, Bellelli A, Cutruzzolà F, Zumft WG, Gutierrez A, Scrutton NS. Kinetics of CO binding and CO photodissociation in Pseudomonas stutzeri cd1 nitrite reductase: Probing the role of extended N-termini in fast structural relaxation upon CO photodissociation Biochemical Journal. 355: 39-43. PMID 11256946 DOI: 10.1042/0264-6021:3550039 |
0.247 |
|
| 2004 |
Toogood HS, van Thiel A, Basran J, Sutcliffe MJ, Scrutton NS, Leys D. Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. The Journal of Biological Chemistry. 279: 32904-12. PMID 15159392 DOI: 10.1074/JBC.M404884200 |
0.247 |
|
| 2010 |
Toogood HS, Gardiner JM, Scrutton NS. ChemInform Abstract: Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases Cheminform. 41: no-no. DOI: 10.1002/CHIN.201046265 |
0.247 |
|
| 2007 |
Jones AR, Hay S, Woodward JR, Scrutton NS. Magnetic field effect studies indicate reduced geminate recombination of the radical pair in substrate-bound adenosylcobalamin-dependent ethanolamine ammonia lyase Journal of the American Chemical Society. 129: 15718-15727. PMID 18041840 DOI: 10.1021/ja077124x |
0.247 |
|
| 2005 |
Rigby SE, Basran J, Combe JP, Mohsen AW, Toogood H, van Thiel A, Sutcliffe MJ, Leys D, Munro AW, Scrutton NS. Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals. Biochemical Society Transactions. 33: 754-7. PMID 16042592 DOI: 10.1042/BST0330754 |
0.247 |
|
| 2009 |
Brenner S, Heyes DJ, Hay S, Hough MA, Eady RR, Hasnain SS, Scrutton NS. Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases. The Journal of Biological Chemistry. 284: 25973-83. PMID 19586913 DOI: 10.1074/jbc.M109.012245 |
0.246 |
|
| 2009 |
Heyes DJ, Quinn AM, Cullis PM, Lee M, Munro AW, Scrutton NS. Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS). Chemical Communications (Cambridge, England). 1124-6. PMID 19225657 DOI: 10.1039/B820386E |
0.245 |
|
| 2008 |
Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 9: 1875-81. PMID 18668493 DOI: 10.1002/cphc.200800303 |
0.244 |
|
| 2020 |
Louka S, Barry SM, Heyes DJ, Mubarak MQE, Ali HS, Alkhalaf LM, Munro AW, Scrutton NS, Challis GL, de Visser SP. Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate. Journal of the American Chemical Society. PMID 32811149 DOI: 10.1021/jacs.0c05070 |
0.244 |
|
| 2009 |
Hothi P, Sutcliffe MJ, Scrutton NS. Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase. The Biochemical Journal. 388: 123-33. PMID 15617516 DOI: 10.1042/BJ20041731 |
0.244 |
|
| 1992 |
Boyd G, Mathews FS, Packman LC, Scrutton NS. Trimethylamine dehydrogenase of bacterium W3A1. Molecular cloning, sequence determination and over-expression of the gene. Febs Letters. 308: 271-6. PMID 1505666 DOI: 10.1016/0014-5793(92)81291-S |
0.244 |
|
| 2021 |
Banner A, Toogood HS, Scrutton NS. Consolidated Bioprocessing: Synthetic Biology Routes to Fuels and Fine Chemicals. Microorganisms. 9. PMID 34069865 DOI: 10.3390/microorganisms9051079 |
0.243 |
|
| 2013 |
Chen ZG, Ziętek MA, Russell HJ, Tait S, Hay S, Jones AR, Scrutton NS. Dynamic, electrostatic model for the generation and control of high-energy radical intermediates by a coenzyme B₁₂-dependent enzyme. Chembiochem : a European Journal of Chemical Biology. 14: 1529-33. PMID 23959797 DOI: 10.1002/cbic.201300420 |
0.242 |
|
| 1999 |
Roberts P, Basran J, Mewies M, Hille R, Scrutton NS. Substrate inhibition in wild-type and mutant trimethylamine dehydrogenases Biochemical Society Transactions. 27: A46-A46. DOI: 10.1042/Bst027A046 |
0.242 |
|
| 2010 |
Wolthers KR, Levy C, Scrutton NS, Leys D. Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. The Journal of Biological Chemistry. 285: 13942-50. PMID 20106986 DOI: 10.1074/jbc.M109.068908 |
0.242 |
|
| 2020 |
Hardman SJO, Iorgu AI, Heyes DJ, Scrutton NS, Sazanovich IV, Hay S. Ultrafast Vibrational Energy Transfer between Protein and Cofactor in a Flavoenzyme. The Journal of Physical Chemistry. B. 124: 5163-5168. PMID 32496802 DOI: 10.1021/acs.jpcb.0c04929 |
0.24 |
|
| 2003 |
Basran J, Harris RJ, Sutcliffe MJ, Scrutton NS. H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase. The Journal of Biological Chemistry. 278: 43973-82. PMID 12941965 DOI: 10.1074/jbc.M305983200 |
0.239 |
|
| 2022 |
Whitehead JN, Leferink NGH, Komati Reddy G, Levy CW, Hay S, Takano E, Scrutton NS. How a 10--Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity. Acs Catalysis. 12: 12123-12131. PMID 36249875 DOI: 10.1021/acscatal.2c03155 |
0.239 |
|
| 2019 |
Ascue Avalos GA, Toogood HS, Tait S, Messiha HL, Scrutton NS. From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 20: 785-792. PMID 30431225 DOI: 10.1002/cbic.201800606 |
0.239 |
|
| 2007 |
Wolthers KR, Scrutton NS. Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation. Biochemistry. 46: 6696-709. PMID 17477549 DOI: 10.1021/BI700339V |
0.238 |
|
| 2021 |
Leferink NGH, Scrutton NS. Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches. Chembiochem : a European Journal of Chemical Biology. PMID 34669250 DOI: 10.1002/cbic.202100484 |
0.237 |
|
| 2010 |
Pang J, Scrutton NS, De Visser SP, Sutcliffe MJ. Assignment of the vibrational spectra of enzyme-bound tryptophan tryptophyl quinones using a combined QM/MM approach Journal of Physical Chemistry A. 114: 1212-1217. PMID 19950920 DOI: 10.1021/jp910161k |
0.237 |
|
| 2006 |
Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Sutcliffe MJ, Scrutton NS, Leys D. Atomic description of an enzyme reaction dominated by proton tunneling. Science (New York, N.Y.). 312: 237-41. PMID 16614214 DOI: 10.1126/SCIENCE.1126002 |
0.237 |
|
| 1999 |
Roberts P, Basran J, Wilson EK, Hille R, Scrutton NS. Redox cycles in trimethylamine dehydrogenase and mechanism of substrate inhibition Biochemistry. 38: 14927-14940. PMID 10555975 DOI: 10.1021/Bi9914098 |
0.237 |
|
| 2013 |
Pudney CR, Guerriero A, Baxter NJ, Johannissen LO, Waltho JP, Hay S, Scrutton NS. Fast protein motions are coupled to enzyme H-transfer reactions. Journal of the American Chemical Society. 135: 2512-7. PMID 23373704 DOI: 10.1021/Ja311277K |
0.236 |
|
| 2003 |
Wolthers KR, Basran J, Munro AW, Scrutton NS. Molecular dissection of human methionine synthase reductase: determination of the flavin redox potentials in full-length enzyme and isolated flavin-binding domains. Biochemistry. 42: 3911-20. PMID 12667082 DOI: 10.1021/BI027290B |
0.235 |
|
| 2004 |
Masgrau L, Basran J, Hothi P, Sutcliffe MJ, Scrutton NS. Hydrogen tunneling in quinoproteins. Archives of Biochemistry and Biophysics. 428: 41-51. PMID 15234268 DOI: 10.1016/J.ABB.2004.03.013 |
0.234 |
|
| 2016 |
Geddes A, Paul CE, Hay S, Hollmann F, Scrutton NS. Donor-Acceptor Distance Sampling Enhances the Performance of "Better than Nature" Nicotinamide Coenzyme Biomimetics. Journal of the American Chemical Society. PMID 27552302 DOI: 10.1021/Jacs.6B05625 |
0.233 |
|
| 1995 |
Raine AR, Yang CC, Packman LC, White SA, Mathews FS, Scrutton NS. Protein recognition of ammonium cations using side-chain aromatics: a structural variation for secondary ammonium ligands. Protein Science : a Publication of the Protein Society. 4: 2625-8. PMID 8580856 DOI: 10.1002/pro.5560041222 |
0.233 |
|
| 2010 |
Pudney CR, Johannissen LO, Sutcliffe MJ, Hay S, Scrutton NS. Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions. Journal of the American Chemical Society. 132: 11329-35. PMID 20698699 DOI: 10.1021/ja1048048 |
0.231 |
|
| 2022 |
Hedison TM, Iorgu AI, Calabrese D, Heyes DJ, Shanmugam M, Scrutton NS. Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron-Electron Double Resonance Spectroscopy Study. The Journal of Physical Chemistry Letters. 13: 6927-6934. PMID 35867774 DOI: 10.1021/acs.jpclett.2c01584 |
0.231 |
|
| 2010 |
Hay S, Brenner S, Khara B, Quinn AM, Rigby SE, Scrutton NS. Nature of the energy landscape for gated electron transfer in a dynamic redox protein. Journal of the American Chemical Society. 132: 9738-45. PMID 20572660 DOI: 10.1021/ja1016206 |
0.231 |
|
| 2017 |
Hedison TM, Hay S, Scrutton NS. A perspective on conformational control of electron transfer in nitric oxide synthases. Nitric Oxide : Biology and Chemistry. 63: 61-67. PMID 27619338 DOI: 10.1016/j.niox.2016.09.002 |
0.23 |
|
| 2004 |
Rigby SE, Hynson RM, Ramsay RR, Munro AW, Scrutton NS. A stable tyrosyl radical in monoamine oxidase A. The Journal of Biological Chemistry. 280: 4627-31. PMID 15556933 DOI: 10.1074/JBC.M410596200 |
0.23 |
|
| 2018 |
Hedison TM, Hay S, Scrutton NS. Trapping methods for probing functional intermediates in nitric oxide synthases and related enzymes. Frontiers in Bioscience (Landmark Edition). 23: 1874-1888. PMID 29772534 |
0.228 |
|
| 2019 |
Leferink NGH, Ranaghan KE, Battye J, Johannissen LO, Hay S, van der Kamp MW, Mulholland AJ, Scrutton NS. Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation. Chembiochem : a European Journal of Chemical Biology. PMID 31682055 DOI: 10.1002/cbic.201900672 |
0.228 |
|
| 2019 |
Hedison TM, Scrutton NS. Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains. The Febs Journal. 286: 2004-2017. PMID 30657259 DOI: 10.1111/febs.14757 |
0.227 |
|
| 2022 |
Taylor A, Heyes DJ, Scrutton NS. Catalysis by Nature's photoenzymes. Current Opinion in Structural Biology. 77: 102491. PMID 36323132 DOI: 10.1016/j.sbi.2022.102491 |
0.227 |
|
| 2016 |
Knaus T, Paul CE, Levy CW, de Vries S, Mutti FG, Hollmann F, Scrutton NS. Better than Nature: nicotinamide biomimetics that outperform natural coenzymes. Journal of the American Chemical Society. PMID 26727612 DOI: 10.1021/Jacs.5B12252 |
0.227 |
|
| 2023 |
Yu Y, Rué Casamajo A, Finnigan W, Schnepel C, Barker R, Morrill C, Heath RS, De Maria L, Turner NJ, Scrutton NS. Structure-Based Design of Small Imine Reductase Panels for Target Substrates. Acs Catalysis. 13: 12310-12321. PMID 37736118 DOI: 10.1021/acscatal.3c02278 |
0.226 |
|
| 2020 |
Wilkes J, Scott-Tucker A, Wright M, Crabbe T, Scrutton NS. Exploiting Single Domain Antibodies as Regulatory Parts to Modulate Monoterpenoid Production in E. coli. Acs Synthetic Biology. PMID 32927940 DOI: 10.1021/acssynbio.0c00375 |
0.226 |
|
| 2000 |
Basran J, Patel S, Sutcliffe MJ, Scrutton NS. Importance of barrier shape in enzyme-catalyzed reactions. Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent amine dehydrogenases. The Journal of Biological Chemistry. 276: 6234-42. PMID 11087744 DOI: 10.1074/JBC.M008141200 |
0.225 |
|
| 2018 |
Hernandez-Ortega A, Vinaixa M, Zebec Z, Takano E, Scrutton NS. A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes. Scientific Reports. 8: 14396. PMID 30258114 DOI: 10.1038/s41598-018-32816-1 |
0.224 |
|
| 2020 |
Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction. Journal of Physical Organic Chemistry. 23: 696-701. PMID 20890464 DOI: 10.1002/POC.1653 |
0.223 |
|
| 2022 |
Green L, Scrutton NS, Currin A. GeneORator: An Efficient Method for the Systematic Mutagenesis of Entire Genes. Methods in Molecular Biology (Clifton, N.J.). 2461: 111-122. PMID 35727446 DOI: 10.1007/978-1-0716-2152-3_7 |
0.222 |
|
| 2012 |
Leferink NG, Eady RR, Hasnain SS, Scrutton NS. Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase. The Febs Journal. 279: 2174-81. PMID 22536809 DOI: 10.1111/j.1742-4658.2012.08601.x |
0.222 |
|
| 2005 |
Marshall KR, Gong M, Wodke L, Lamb JH, Jones DJ, Farmer PB, Scrutton NS, Munro AW. The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. The Journal of Biological Chemistry. 280: 30735-40. PMID 15958387 DOI: 10.1074/jbc.M414018200 |
0.218 |
|
| 2013 |
Russell HJ, Hardman SJO, Heyes DJ, Hough MA, Greetham GM, Towrie M, Hay S, Scrutton NS. Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range Febs Journal. 280: 6070-6082. PMID 24034856 DOI: 10.1111/febs.12526 |
0.217 |
|
| 2003 |
Finn RD, Basran J, Roitel O, Wolf CR, Munro AW, Paine MJ, Scrutton NS. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. European Journal of Biochemistry / Febs. 270: 1164-75. PMID 12631275 DOI: 10.1046/J.1432-1033.2003.03474.X |
0.216 |
|
| 2006 |
Tejero J, Peregrina JR, Martínez-Júlvez M, Gutiérrez A, Gómez-Moreno C, Scrutton NS, Medina M. Catalytic mechanism of hydride transfer between NADP+/H and ferredoxin-NADP+ reductase from Anabaena PCC 7119. Archives of Biochemistry and Biophysics. 459: 79-90. PMID 17224127 DOI: 10.1016/J.ABB.2006.10.023 |
0.215 |
|
| 2015 |
Toogood HS, Cheallaigh AN, Tait S, Mansell DJ, Jervis A, Lygidakis A, Humphreys L, Takano E, Gardiner JM, Scrutton NS. Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli. Acs Synthetic Biology. 4: 1112-23. PMID 26017480 DOI: 10.1021/Acssynbio.5B00092 |
0.214 |
|
| 2019 |
Delgado M, Görlich S, Longbotham JE, Scrutton NS, Hay S, Moliner V, Tuñón I. Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer. Acs Catalysis. 7: 3190-3198. PMID 31157122 DOI: 10.1021/acscatal.7b00201 |
0.214 |
|
| 2020 |
Hedison TM, Breslmayr E, Shanmugam M, Karnpakdee K, Heyes DJ, Green AP, Ludwig R, Scrutton NS, Kracher D. Insights into the H O -driven catalytic mechanism of fungal lytic polysaccharide monooxygenases. The Febs Journal. PMID 33411405 DOI: 10.1111/febs.15704 |
0.214 |
|
| 2018 |
Knaus T, Tseliou V, Humphreys LD, Scrutton NS, Mutti FG. A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 20: 3931-3943. PMID 33568964 DOI: 10.1039/c8gc01381k |
0.213 |
|
| 2008 |
Hay S, Pang J, Monaghan PJ, Wang X, Evans RM, Sutcliffe MJ, Allemann RK, Scrutton NS. Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 9: 1536-9. PMID 18613201 DOI: 10.1002/Cphc.200800291 |
0.213 |
|
| 2014 |
Toogood HS, Scrutton NS. New developments in 'ene'-reductase catalysed biological hydrogenations. Current Opinion in Chemical Biology. 19: 107-15. PMID 24608082 DOI: 10.1016/j.cbpa.2014.01.019 |
0.213 |
|
| 2002 |
Gutierrez A, Paine M, Wolf CR, Scrutton NS, Roberts GC. Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding. Biochemistry. 41: 4626-37. PMID 11926825 DOI: 10.1021/BI0159433 |
0.213 |
|
| 2014 |
Hardman SJ, Hauck AF, Clark IP, Heyes DJ, Scrutton NS. Comprehensive analysis of the green-to-blue photoconversion of full-length Cyanobacteriochrome Tlr0924. Biophysical Journal. 107: 2195-203. PMID 25418104 DOI: 10.1016/j.bpj.2014.09.020 |
0.213 |
|
| 2023 |
Whitehead JN, Leferink NGH, Johannissen LO, Hay S, Scrutton NS. Decoding Catalysis by Terpene Synthases. Acs Catalysis. 13: 12774-12802. PMID 37822860 DOI: 10.1021/acscatal.3c03047 |
0.212 |
|
| 2014 |
Hauck AF, Hardman SJ, Kutta RJ, Greetham GM, Heyes DJ, Scrutton NS. The photoinitiated reaction pathway of full-length cyanobacteriochrome Tlr0924 monitored over 12 orders of magnitude. The Journal of Biological Chemistry. 289: 17747-57. PMID 24817121 DOI: 10.1074/jbc.M114.566133 |
0.211 |
|
| 2007 |
Toogood HS, Leys D, Scrutton NS. Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes. The Febs Journal. 274: 5481-504. PMID 17941859 DOI: 10.1111/j.1742-4658.2007.06107.x |
0.211 |
|
| 1998 |
Lee HJ, Basran J, Scrutton NS. Electron transfer from flavin to iron in the Pseudomonas oleovorans rubredoxin reductase-rubredoxin electron transfer complex. Biochemistry. 37: 15513-22. PMID 9799514 DOI: 10.1021/BI981853V |
0.211 |
|
| 2003 |
Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS. Extensive conformational sampling in a ternary electron transfer complex. Nature Structural Biology. 10: 219-25. PMID 12567183 DOI: 10.1038/nsb894 |
0.209 |
|
| 1994 |
Scrutton NS. alpha/beta barrel evolution and the modular assembly of enzymes: emerging trends in the flavin oxidase/dehydrogenase family. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 16: 115-22. PMID 8147842 DOI: 10.1002/BIES.950160208 |
0.209 |
|
| 2009 |
Jones AR, Woodward JR, Scrutton NS. Continuous wave photolysis magnetic field effect investigations with free and protein-bound alkylcobalamins Journal of the American Chemical Society. 131: 17246-17253. PMID 19899795 DOI: 10.1021/ja9059238 |
0.208 |
|
| 2017 |
Liu KC, Hughes JMX, Hay S, Scrutton NS. Liver microsomal lipid enhances the activity and redox coupling of co-localised cytochrome P450 reductase-cytochrome P450 3A4 in nanodiscs. The Febs Journal. PMID 28618157 DOI: 10.1111/febs.14129 |
0.207 |
|
| 2013 |
Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 496: 382-5. PMID 23575632 DOI: 10.1038/Nature12039 |
0.207 |
|
| 2016 |
Leys D, Scrutton NS. Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism. Current Opinion in Structural Biology. 41: 19-26. PMID 27266331 DOI: 10.1016/j.sbi.2016.05.014 |
0.206 |
|
| 2015 |
Knaus T, Mutti FG, Humphreys LD, Turner NJ, Scrutton NS. Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes. Organic & Biomolecular Chemistry. 13: 223-33. PMID 25372591 DOI: 10.1039/c4ob02282c |
0.206 |
|
| 2007 |
Hothi P, Roujeinikova A, Khadra KA, Lee M, Cullis PM, Leys D, Scrutton NS. Isotope effects reveal that para-substituted benzylamines are poor reactivity probes of the quinoprotein mechanism for aromatic amine dehydrogenase. Biochemistry. 46: 9250-9259. PMID 17636875 DOI: 10.1021/Bi7007239 |
0.206 |
|
| 2018 |
Archipowa N, Kutta RJ, Heyes DJ, Scrutton NS. Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase. Angewandte Chemie (International Ed. in English). 57: 2682-2686. PMID 29363234 DOI: 10.1002/anie.201712729 |
0.204 |
|
| 2000 |
Jang MH, Scrutton NS, Hille R. Formation of W3A1 electron-transferring flavoprotein (ETF) hydroquinone in the trimethylamine dehydrogenase-ETF protein complex Journal of Biological Chemistry. 275: 12546-12552. PMID 10777543 DOI: 10.1074/jbc.275.17.12546 |
0.201 |
|
| 2004 |
Olteanu H, Wolthers KR, Munro AW, Scrutton NS, Banerjee R. Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase. Biochemistry. 43: 1988-97. PMID 14967039 DOI: 10.1021/Bi035910I |
0.201 |
|
| 2012 |
Heuts DP, Weissenborn MJ, Olkhov RV, Shaw AM, Gummadova J, Levy C, Scrutton NS. Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem : a European Journal of Chemical Biology. 13: 2384-91. PMID 22997138 DOI: 10.1002/cbic.201200426 |
0.201 |
|
| 1997 |
Moody PC, Shikotra N, French CE, Bruce NC, Scrutton NS. Crystallization and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids. Acta Crystallographica. Section D, Biological Crystallography. 53: 619-21. PMID 15299897 DOI: 10.1107/S0907444997004046 |
0.2 |
|
| 2007 |
Johannissen LO, Hay S, Scrutton NS, Sutcliffe MJ. Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment. The Journal of Physical Chemistry. B. 111: 2631-8. PMID 17305385 DOI: 10.1021/JP066276W |
0.2 |
|
| 2021 |
Currin A, Parker S, Robinson CJ, Takano E, Scrutton NS, Breitling R. The evolving art of creating genetic diversity: From directed evolution to synthetic biology. Biotechnology Advances. 107762. PMID 34000294 DOI: 10.1016/j.biotechadv.2021.107762 |
0.2 |
|
| 2011 |
Antonyuk SV, Rustage N, Petersen CA, Arnst JL, Heyes DJ, Sharma R, Berry NG, Scrutton NS, Eady RR, Andrew CR, Hasnain SS. Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins. Proceedings of the National Academy of Sciences of the United States of America. 108: 15780-5. PMID 21900609 DOI: 10.1073/pnas.1109051108 |
0.199 |
|
| 2004 |
Perry A, Tambyrajah W, Grossmann JG, Lian LY, Scrutton NS. Solution structure of the two-iron rubredoxin of Pseudomonas oleovorans determined by NMR spectroscopy and solution X-ray scattering and interactions with rubredoxin reductase. Biochemistry. 43: 3167-82. PMID 15023067 DOI: 10.1021/BI035817U |
0.199 |
|
| 2016 |
Mutti FG, Knaus T, Scrutton NS, Breuer M, Turner NJ. ChemInform Abstract: Conversion of Alcohols to Enantiopure Amines Through Dual-Enzyme Hydrogen-Borrowing Cascades. Cheminform. 47: no-no. DOI: 10.1002/CHIN.201606085 |
0.198 |
|
| 2009 |
Hay S, Evans RM, Levy C, Loveridge EJ, Wang X, Leys D, Allemann RK, Scrutton NS. Are the catalytic properties of enzymes from piezophilic organisms pressure adapted? Chembiochem : a European Journal of Chemical Biology. 10: 2348-53. PMID 19681091 DOI: 10.1002/Cbic.200900367 |
0.198 |
|
| 2009 |
Wolthers KR, Scrutton NS. Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex. The Febs Journal. 276: 1942-51. PMID 19243433 DOI: 10.1111/j.1742-4658.2009.06919.x |
0.198 |
|
| 2004 |
Mohsen AW, Rigby SE, Jensen KF, Munro AW, Scrutton NS. Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy. Biochemistry. 43: 6498-510. PMID 15157083 DOI: 10.1021/bi036179i |
0.198 |
|
| 2009 |
Heyes DJ, Sakuma M, Scrutton NS. Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase. Angewandte Chemie (International Ed. in English). 48: 3850-3. PMID 19373814 DOI: 10.1002/anie.200900086 |
0.197 |
|
| 1997 |
Wilson EK, Scrutton NS, Cölfen H, Harding SE, Jacobsen MP, Winzor DJ. An ultracentrifugal approach to quantitative characterization of the molecular assembly of a physiological electron-transfer complex: the interaction of electron-transferring flavoprotein with trimethylamine dehydrogenase. European Journal of Biochemistry / Febs. 243: 393-9. PMID 9030764 DOI: 10.1111/J.1432-1033.1997.0393A.X |
0.196 |
|
| 2019 |
Leferink NGH, Dunstan MS, Hollywood KA, Swainston N, Currin A, Jervis AJ, Takano E, Scrutton NS. An automated pipeline for the screening of diverse monoterpene synthase libraries. Scientific Reports. 9: 11936. PMID 31417136 DOI: 10.1038/s41598-019-48452-2 |
0.195 |
|
| 2003 |
Munro AW, McLean KJ, Marshall KR, Warman AJ, Lewis G, Roitel O, Sutcliffe MJ, Kemp CA, Modi S, Scrutton NS, Leys D. Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis. Biochemical Society Transactions. 31: 625-30. PMID 12773169 DOI: 10.1042/BST0310625 |
0.194 |
|
| 2009 |
Hay S, Pudney CR, McGrory TA, Pang J, Sutcliffe MJ, Scrutton NS. Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angewandte Chemie (International Ed. in English). 48: 1452-4. PMID 19145622 DOI: 10.1002/anie.200805502 |
0.194 |
|
| 2017 |
Kekilli D, Petersen CA, Pixton DA, Ghafoor DD, Abdullah GH, Dworkowski FSN, Wilson MT, Heyes DJ, Hardman SJO, Murphy LM, Strange RW, Scrutton NS, Andrew CR, Hough MA. Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design. Chemical Science. 8: 1986-1994. PMID 28451315 DOI: 10.1039/C6Sc04190F |
0.194 |
|
| 2005 |
Scrutton NS, Leys D. Crystal structure of DMGO provides a prototype for a new tetrahydrofolate-binding fold. Biochemical Society Transactions. 33: 776-9. PMID 16042597 DOI: 10.1042/BST0330776 |
0.194 |
|
| 2008 |
Nivinskas H, Sarlauskas J, Anusevicius Z, Toogood HS, Scrutton NS, Cenas N. Reduction of aliphatic nitroesters and N-nitramines by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships. The Febs Journal. 275: 6192-203. PMID 19016851 DOI: 10.1111/j.1742-4658.2008.06744.x |
0.193 |
|
| 2001 |
Jones M, Talfournier F, Bobrov A, Grossmann JG, Vekshin N, Sutcliffe MJ, Scrutton NS. Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein. The Journal of Biological Chemistry. 277: 8457-65. PMID 11756429 DOI: 10.1074/JBC.M111105200 |
0.193 |
|
| 2007 |
Girvan HM, Heyes DJ, Scrutton NS, Munro AW. Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale. Journal of the American Chemical Society. 129: 6647-53. PMID 17465554 DOI: 10.1021/ja071355m |
0.193 |
|
| 2005 |
Leys D, Basran J, Talfournier F, Chohan KK, Munro AW, Sutcliffe MJ, Scrutton NS. Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron-transferring flavoprotein complex. Biochemical Society Symposium. 1-14. PMID 15777008 DOI: 10.1042/BSS0710001 |
0.193 |
|
| 2012 |
Heyes DJ, Khara B, Sakuma M, Hardman SJ, O'Cualain R, Rigby SE, Scrutton NS. Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state. Plos One. 7: e52418. PMID 23300666 DOI: 10.1371/journal.pone.0052418 |
0.192 |
|
| 1998 |
Moody PCE, Shikotra N, French CE, Bruce NC, Scrutton NS. Crystallization and preliminary diffraction studies of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2 Acta Crystallographica Section D: Biological Crystallography. 54: 675-677. PMID 9761872 DOI: 10.1107/S0907444997017836 |
0.192 |
|
| 2011 |
Heuts DP, Gummadova JO, Pang J, Rigby SE, Scrutton NS. Reaction of vascular adhesion protein-1 (VAP-1) with primary amines: mechanistic insights from isotope effects and quantitative structure-activity relationships. The Journal of Biological Chemistry. 286: 29584-93. PMID 21737458 DOI: 10.1074/jbc.M111.232850 |
0.191 |
|
| 2022 |
Rinaldi MA, Tait S, Toogood HS, Scrutton NS. Bioproduction of Linalool From Paper Mill Waste. Frontiers in Bioengineering and Biotechnology. 10: 892896. PMID 35711639 DOI: 10.3389/fbioe.2022.892896 |
0.19 |
|
| 2023 |
Kumar V, Agrawal D, Bommareddy RR, Islam MA, Jacob S, Balan V, Singh V, Thakur VK, Navani NK, Scrutton NS. Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks. Critical Reviews in Biotechnology. 1-18. PMID 37932016 DOI: 10.1080/07388551.2023.2270702 |
0.188 |
|
| 2021 |
Toogood HS, Scrutton NS. Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases. The Biochemical Journal. 478: 3423-3428. PMID 34554213 DOI: 10.1042/BCJ20210489 |
0.188 |
|
| 2016 |
Johannissen LO, Hay S, Scrutton NS. Nuclear quantum tunnelling in enzymatic reactions--an enzymologist's perspective. Physical Chemistry Chemical Physics : Pccp. 17: 30775-82. PMID 25835565 DOI: 10.1039/c5cp00614g |
0.187 |
|
| 2008 |
Pang J, Hay S, Scrutton NS, Sutcliffe MJ. Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase. Journal of the American Chemical Society. 130: 7092-7. PMID 18470990 DOI: 10.1021/ja800471f |
0.186 |
|
| 2007 |
Hay S, Sutcliffe MJ, Scrutton NS. Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects. Proceedings of the National Academy of Sciences of the United States of America. 104: 507-12. PMID 17202258 DOI: 10.1073/pnas.0608408104 |
0.185 |
|
| 2022 |
Park H, Toogood HS, Chen GQ, Scrutton NS. Co-production of biofuel, bioplastics and biochemicals during extended fermentation of Halomonas bluephagenesis. Microbial Biotechnology. PMID 36353812 DOI: 10.1111/1751-7915.14158 |
0.185 |
|
| 2024 |
Zhang S, Jeffreys LN, Poddar H, Yu Y, Liu C, Patel K, Johannissen LO, Zhu L, Cliff MJ, Yan C, Schirò G, Weik M, Sakuma M, Levy CW, Leys D, ... ... Scrutton NS, et al. Photocobilins integrate B and bilin photochemistry for enzyme control. Nature Communications. 15: 2740. PMID 38548733 DOI: 10.1038/s41467-024-46995-1 |
0.184 |
|
| 2012 |
Hay S, Scrutton NS. Good vibrations in enzyme-catalysed reactions. Nature Chemistry. 4: 161-8. PMID 22354429 DOI: 10.1038/nchem.1223 |
0.183 |
|
| 2020 |
Gerke J, Frauendorf H, Schneider D, Wintergoller M, Hofmeister T, Poehlein A, Zebec Z, Takano E, Scrutton NS, Braus GH. Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker's Yeast. Frontiers in Bioengineering and Biotechnology. 8: 582052. PMID 33102464 DOI: 10.3389/fbioe.2020.582052 |
0.183 |
|
| 2009 |
Hay S, Pudney CR, Hothi P, Scrutton NS. Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation. The Journal of Physical Chemistry. A. 112: 13109-15. PMID 18847184 DOI: 10.1021/jp805107n |
0.181 |
|
| 2015 |
Messiha HL, Wongnate T, Chaiyen P, Jones AR, Scrutton NS. Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 25505136 DOI: 10.1098/Rsif.2014.1155 |
0.181 |
|
| 2005 |
Monaghan PJ, Leys D, Scrutton NS. Crystallization and preliminary X-ray diffraction analysis of a flavoenzyme amine dehydrogenase/oxidase from Pyrococcus furiosus DSM 3638. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 756-8. PMID 16511149 DOI: 10.1107/S1744309105020737 |
0.179 |
|
| 2015 |
Menon N, Pásztor A, Menon BR, Kallio P, Fisher K, Akhtar MK, Leys D, Jones PR, Scrutton NS. A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnology For Biofuels. 8: 61. PMID 25866563 DOI: 10.1186/S13068-015-0231-1 |
0.176 |
|
| 1996 |
Scrutton NS, Raine AR. Cation-pi bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands. The Biochemical Journal. 319: 1-8. PMID 8870640 DOI: 10.1042/BJ3190001 |
0.176 |
|
| 2018 |
Kutta RJ, Archipowa N, Scrutton NS. The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster. Physical Chemistry Chemical Physics : Pccp. 20: 28767-28776. PMID 30417904 DOI: 10.1039/c8cp04671a |
0.175 |
|
| 2000 |
Basran J, Chohan KK, Sutcliffe MJ, Scrutton NS. Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein. Biochemistry. 39: 9188-200. PMID 10924112 DOI: 10.1021/BI0006868 |
0.175 |
|
| 2012 |
Vieira J, Jones AR, Danon A, Sakuma M, Hoang N, Robles D, Tait S, Heyes DJ, Picot M, Yoshii T, Helfrich-Förster C, Soubigou G, Coppee JY, Klarsfeld A, Rouyer F, ... Scrutton NS, et al. Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. Plos One. 7: e31867. PMID 22427812 DOI: 10.1371/Journal.Pone.0031867 |
0.175 |
|
| 2013 |
Khara B, Menon N, Levy C, Mansell D, Das D, Marsh EN, Leys D, Scrutton NS. Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase. Chembiochem : a European Journal of Chemical Biology. 14: 1204-8. PMID 23757044 DOI: 10.1002/Cbic.201300307 |
0.175 |
|
| 2001 |
Stevenson TH, Gutierrez AF, Alderton WK, Lian L, Scrutton NS. Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands. The Biochemical Journal. 358: 201-8. PMID 11485568 DOI: 10.1042/0264-6021:3580201 |
0.174 |
|
| 2020 |
Roberts AD, Finnigan W, Kelly PP, Faulkner M, Breitling R, Takano E, Scrutton NS, Blaker JJ, Hay S. Non-covalent protein-based adhesives for transparent substrates-bovine serum albumin vs. recombinant spider silk. Materials Today. Bio. 7: 100068. PMID 32695986 DOI: 10.1016/j.mtbio.2020.100068 |
0.174 |
|
| 2001 |
Faulder PF, Tresadern G, Chohan KK, Scrutton NS, Sutcliffe MJ, Hillier IH, Burton NA. QM/MM studies show substantial tunneling for the hydrogen-transfer reaction in methylamine dehydrogenase. Journal of the American Chemical Society. 123: 8604-5. PMID 11525672 DOI: 10.1021/ja016219a |
0.173 |
|
| 1999 |
Basran J, Sutcliffe MJ, Scrutton NS. Enzymatic H-transfer requires vibration-driven extreme tunneling. Biochemistry. 38: 3218-22. PMID 10074378 DOI: 10.1021/BI982719D |
0.173 |
|
| 2021 |
Heyes DJ, Zhang S, Taylor A, Johannissen LO, Hardman SJO, Hay S, Scrutton NS. Photocatalysis as the 'master switch' of photomorphogenesis in early plant development. Nature Plants. PMID 33686224 DOI: 10.1038/s41477-021-00866-5 |
0.173 |
|
| 2021 |
Dhillon P, Scrutton NS. In conversation with Nigel Scrutton. The Febs Journal. 288: 1728-1733. PMID 33373117 DOI: 10.1111/febs.15632 |
0.172 |
|
| 2018 |
Cheallaigh AN, Mansell DJ, Toogood HS, Tait S, Lygidakis A, Scrutton NS, Gardiner JM. Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway. Journal of Natural Products. PMID 29979593 DOI: 10.1021/Acs.Jnatprod.7B01026 |
0.171 |
|
| 2012 |
Convery JH, Smith CI, Khara B, Scrutton NS, Harrison P, Farrell T, Martin DS, Weightman P. Controlling the formation of a monolayer of cytochrome P450 reductase onto Au surfaces. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 86: 011903. PMID 23005448 DOI: 10.1103/PhysRevE.86.011903 |
0.171 |
|
| 2015 |
Mutti FG, Knaus T, Scrutton NS, Breuer M, Turner NJ. Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. Science (New York, N.Y.). 349: 1525-9. PMID 26404833 DOI: 10.1126/science.aac9283 |
0.171 |
|
| 1996 |
Wilson EK, Huang L, Hille R, Mathews FS, Scrutton NS. Electron transfer in trimethylamine dehydrogenase : Directed mutagenesis of a potential tunneling pathway Biochemical Society Transactions. 24. PMID 8879000 DOI: 10.1042/bst024456s |
0.17 |
|
| 2022 |
Poddar H, Heyes DJ, Zhang S, Hardman SJ, Sakuma M, Scrutton NS. An unusual light-sensing function for coenzyme B in bacterial transcription regulator CarH. Methods in Enzymology. 668: 349-372. PMID 35589201 DOI: 10.1016/bs.mie.2021.12.010 |
0.168 |
|
| 2017 |
Brandariz-de-Pedro G, Heyes DJ, Hardman SJ, Shanmugam M, Jones AR, Weber S, Nohr D, Scrutton NS, Fielding AJ. Direct Evidence of an Excited State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide. The Journal of Physical Chemistry Letters. PMID 28244763 DOI: 10.1021/acs.jpclett.7b00200 |
0.168 |
|
| 2010 |
Pudney CR, Hay S, Levy C, Pang J, Sutcliffe MJ, Leys D, Scrutton NS. Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. Journal of the American Chemical Society. 131: 17072-3. PMID 19891489 DOI: 10.1021/ja908469m |
0.167 |
|
| 2014 |
Smith CI, Convery JH, Harrison P, Khara B, Scrutton NS, Weightman P. Conformational change in cytochrome P450 reductase adsorbed at a Au(110)-phosphate buffer interface induced by interaction with nicotinamide adenine dinucleotide phosphate. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 90: 022708. PMID 25215759 DOI: 10.1103/PhysRevE.90.022708 |
0.167 |
|
| 1996 |
Mewies M, Packman LC, Scrutton NS. Dissection of the FMN-binding site in trimethylamine dehydrogenase. Biochemical Society Transactions. 23: 509S. PMID 8654694 DOI: 10.1042/BST023509S |
0.167 |
|
| 2023 |
Poddar H, Rios-Santacruz R, Heyes DJ, Shanmugam M, Brookfield A, Johannissen LO, Levy CW, Jeffreys LN, Zhang S, Sakuma M, Colletier JP, Hay S, Schirò G, Weik M, Scrutton NS, et al. Redox driven B-ligand switch drives CarH photoresponse. Nature Communications. 14: 5082. PMID 37604813 DOI: 10.1038/s41467-023-40817-6 |
0.166 |
|
| 2013 |
Weightman P, Smith CI, Convery JH, Harrison P, Khara B, Scrutton NS. Conformational change induced by electron transfer in a monolayer of cytochrome P450 reductase adsorbed at the Au(110)-phosphate buffer interface. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 88: 032715. PMID 24125302 DOI: 10.1103/PhysRevE.88.032715 |
0.166 |
|
| 2008 |
Brenner S, Hay S, Munro AW, Scrutton NS. Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism. The Febs Journal. 275: 4540-57. PMID 18681889 DOI: 10.1111/j.1742-4658.2008.06597.x |
0.166 |
|
| 2000 |
Jones M, Basran J, Sutcliffe MJ, Günter Grossmann J, Scrutton NS. X-ray scattering studies of Methylophilus methylotrophus (sp. W3A1) electron-transferring flavoprotein. Evidence for multiple conformational states and an induced fit mechanism for assembly with trimethylamine dehydrogenase. The Journal of Biological Chemistry. 275: 21349-54. PMID 10766748 DOI: 10.1074/JBC.M001564200 |
0.164 |
|
| 2019 |
Messiha HL, Smith CI, Scrutton NS, Weightman P. Evidence for protein conformational change at a Au(110)/protein interface. Europhysics Letters. 83: 180004. PMID 19325933 DOI: 10.1209/0295-5075/83/18004 |
0.163 |
|
| 2021 |
Poddar H, Heyes DJ, Schirò G, Weik M, Leys D, Scrutton NS. A guide to time-resolved structural analysis of light-activated proteins. The Febs Journal. PMID 33864718 DOI: 10.1111/febs.15880 |
0.163 |
|
| 2001 |
Chohan KK, Jones M, Grossmann JG, Frerman FE, Scrutton NS, Sutcliffe MJ. Protein dynamics enhance electronic coupling in electron transfer complexes. The Journal of Biological Chemistry. 276: 34142-7. PMID 11429403 DOI: 10.1074/jbc.M101341200 |
0.163 |
|
| 2016 |
Czarnota S, Baxter NJ, Cliff MJ, Waltho JP, Scrutton NS, Hay S. (1)H, (15)N, (13)C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol. Biomolecular Nmr Assignments. PMID 27981425 DOI: 10.1007/S12104-016-9720-9 |
0.162 |
|
| 2018 |
Messiha HL, Ahmed ST, Karuppiah V, Suardiaz R, Ascue Avalos GA, Fey N, Yeates S, Toogood HS, Mulholland AJ, Scrutton NS. Biocatalytic Routes to Lactone Monomers for Polymer Production. Biochemistry. PMID 29533655 DOI: 10.1021/Acs.Biochem.8B00169 |
0.161 |
|
| 2007 |
Dunford AJ, McLean KJ, Sabri M, Seward HE, Heyes DJ, Scrutton NS, Munro AW. Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium. The Journal of Biological Chemistry. 282: 24816-24. PMID 17553785 DOI: 10.1074/jbc.M702958200 |
0.161 |
|
| 2016 |
Leferink NGH, Jervis AJ, Zebec Z, Toogood HS, Hay S, Takano E, Scrutton NS. A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in . Chemistryselect. 1: 1893-1896. PMID 29756025 DOI: 10.1002/slct.201600563 |
0.16 |
|
| 2010 |
Pang J, Scrutton NS, De Visser SP, Sutcliffe MJ. New insights into the multi-step reaction pathway of the reductive half-reaction catalysed by aromatic amine dehydrogenase: A QM/MM study Chemical Communications. 46: 3104-3106. PMID 20376394 DOI: 10.1039/c003107k |
0.16 |
|
| 2011 |
Jones AR, Hardman SJ, Hay S, Scrutton NS. Is there a dynamic protein contribution to the substrate trigger in coenzyme B12-dependent ethanolamine ammonia lyase? Angewandte Chemie (International Ed. in English). 50: 10843-6. PMID 21948289 DOI: 10.1002/anie.201105132 |
0.159 |
|
| 2018 |
Issa IS, Toogood HS, Johannissen LO, Raftery J, Scrutton NS, Gardiner JM. C3 and C6 Modification-specific OYE biotransformations of synthetic carvones and sequential BVMO chemoenzymatic synthesis of chiral caprolactones . Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30468546 DOI: 10.1002/Chem.201805219 |
0.158 |
|
| 2010 |
Mohr S, Fisher K, Scrutton NS, Goddard NJ, Fielden PR. Continuous two-phase flow miniaturised bioreactor for monitoring anaerobic biocatalysis by pentaerythritol tetranitrate reductase. Lab On a Chip. 10: 1929-36. PMID 20526519 DOI: 10.1039/C003561K |
0.157 |
|
| 2015 |
Hernández-Ortega A, Quesne MG, Bui S, Heyes DJ, Steiner RA, Scrutton NS, De Visser SP. Catalytic Mechanism of Cofactor-Free Dioxygenases and How They Circumvent Spin-Forbidden Oxygenation of Their Substrates Journal of the American Chemical Society. 137: 7474-7487. DOI: 10.1021/jacs.5b03836 |
0.156 |
|
| 2010 |
Hulley ME, Toogood HS, Fryszkowska A, Mansell D, Stephens GM, Gardiner JM, Scrutton NS. Inside Cover: Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries (ChemBioChem 17/2010) Chembiochem. 11: 2326-2326. DOI: 10.1002/Cbic.201090083 |
0.156 |
|
| 2024 |
Hu Q, Sun S, Zhang Z, Liu W, Yi X, He H, Scrutton NS, Chen GQ. Ectoine hyperproduction by engineered Halomonas bluephagenesis. Metabolic Engineering. 82: 238-249. PMID 38401747 DOI: 10.1016/j.ymben.2024.02.010 |
0.155 |
|
| 2018 |
Scrutton N, Choudry U, Heyes D, Hardman S, Sakuma M, Sazanovich I, Woodhouse J, De La Mora E, Pederson M, Wulff M, Weik M, Schiro G. Photochemical mechanism of an atypical algal phytochrome. Chembiochem : a European Journal of Chemical Biology. PMID 29544024 DOI: 10.1002/Cbic.201800016 |
0.155 |
|
| 2014 |
Kandathil SM, Driscoll MD, Dunn RV, Scrutton NS, Hay S. Proton tunnelling and promoting vibrations during the oxidation of ascorbate by ferricyanide? Physical Chemistry Chemical Physics : Pccp. 16: 2256-9. PMID 24394921 DOI: 10.1039/c3cp55131h |
0.154 |
|
| 2005 |
Leys D, Scrutton NS. Electrical circuitry in biology: emerging principles from protein structure. Current Opinion in Structural Biology. 14: 642-7. PMID 15582386 DOI: 10.1016/J.SBI.2004.10.002 |
0.154 |
|
| 2019 |
Hedison TM, Heyes DJ, Shanmugam M, Iorgu AI, Scrutton NS. Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase. Chemical Communications (Cambridge, England). 55: 5863-5866. PMID 31049498 DOI: 10.1039/C9CC01026B |
0.153 |
|
| 2016 |
Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, ... ... Scrutton NS, et al. SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. Biochemical Society Transactions. 44: 675-7. PMID 27284023 DOI: 10.1042/Bst20160009 |
0.151 |
|
| 2020 |
Dunstan MS, Robinson CJ, Jervis AJ, Yan C, Carbonell P, Hollywood KA, Currin A, Swainston N, Feuvre RL, Micklefield J, Faulon JL, Breitling R, Turner N, Takano E, Scrutton NS. Engineering towards production of gatekeeper (2)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol. Synthetic Biology (Oxford, England). 5: ysaa012. PMID 33195815 DOI: 10.1093/Synbio/Ysaa012 |
0.151 |
|
| 2001 |
Perry A, Lian LY, Scrutton NS. Two-iron rubredoxin of Pseudomonas oleovorans: production, stability and characterization of the individual iron-binding domains by optical, CD and NMR spectroscopies. The Biochemical Journal. 354: 89-98. PMID 11171083 DOI: 10.1042/0264-6021:3540089 |
0.15 |
|
| 2015 |
Kutta RJ, Hardman SJ, Johannissen LO, Bellina B, Messiha HL, Ortiz-Guerrero JM, Elías-Arnanz M, Padmanabhan S, Barran P, Scrutton NS, Jones AR. The photochemical mechanism of a B12-dependent photoreceptor protein. Nature Communications. 6: 7907. PMID 26264192 DOI: 10.1038/Ncomms8907 |
0.149 |
|
| 2018 |
Jervis AJ, Carbonell P, Vinaixa M, Dunstan MS, Hollywood KA, Robinson CJ, Rattray NJW, Yan C, Swainston N, Currin A, Sung R, Toogood HS, Taylor S, Faulon JL, Breitling R, ... ... Scrutton NS, et al. Machine learning of designed translational control allows predictive pathway optimisation in Escherichia coli. Acs Synthetic Biology. PMID 30563328 DOI: 10.1021/acssynbio.8b00398 |
0.148 |
|
| 2019 |
Hughes JA, Hardman SJO, Scrutton NS, Graham DM, Woodward JR, Jones AR. Observation of the Δg mechanism resulting from the ultrafast spin dynamics that follow the photolysis of coenzyme B. The Journal of Chemical Physics. 151: 201102. PMID 31779325 DOI: 10.1063/1.5127258 |
0.148 |
|
| 2007 |
Miseviciene L, Anusevicius Z, Sarlauskas J, Harris RJ, Scrutton NS, Cenas N. Two-electron reduction of quinones by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships. Acta Biochimica Polonica. 54: 379-85. PMID 17546202 |
0.147 |
|
| 1996 |
C�lfen H, Harding S, Wilson E, Packman L, Scrutton N. Homodimeric and expanded behaviour of trimethylamine dehydrogenase in solution at different temperatures European Biophysics Journal. 24. DOI: 10.1007/Bf00180273 |
0.146 |
|
| 2020 |
Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Swainston N, Spiess R, Taylor S, Mulherin P, Parker S, Rowe W, Matthews NE, Malone KJ, ... ... Scrutton NS, et al. Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers. Metabolic Engineering. PMID 32335188 DOI: 10.1016/J.Ymben.2020.04.008 |
0.145 |
|
| 2020 |
Hardman SJO, Heyes DJ, Sazanovich IV, Scrutton NS. Photocycle of Cyanobacteriochrome TePixJ. Biochemistry. 59: 2909-2915. PMID 32786403 DOI: 10.1021/acs.biochem.0c00382 |
0.145 |
|
| 2016 |
Zebec Z, Wilkes J, Jervis AJ, Scrutton NS, Takano E, Breitling R. Towards synthesis of monoterpenes and derivatives using synthetic biology Current Opinion in Chemical Biology. 34: 37-43. DOI: 10.1016/j.cbpa.2016.06.002 |
0.143 |
|
| 2022 |
Stewart AM, Shanmugam M, Kutta RJ, Scrutton NS, Lovett JE, Hay S. Combined Pulsed Electron Double Resonance EPR and Molecular Dynamics Investigations of Calmodulin Suggest Effects of Crowding Agents on Protein Structures. Biochemistry. PMID 35979922 DOI: 10.1021/acs.biochem.2c00099 |
0.143 |
|
| 2013 |
Mansell DJ, Toogood HS, Waller J, Hughes JMX, Levy CW, Gardiner JM, Scrutton NS. Biocatalytic asymmetric alkene reduction: Crystal structure and characterization of a double bond reductase from Nicotiana tabacum Acs Catalysis. 3: 370-379. DOI: 10.1021/cs300709m |
0.143 |
|
| 2016 |
Zebec Z, Wilkes J, Jervis AJ, Scrutton NS, Takano E, Breitling R. Towards synthesis of monoterpenes and derivatives using synthetic biology. Current Opinion in Chemical Biology. 34: 37-43. PMID 27315341 DOI: 10.1016/j.cbpa.2016.06.002 |
0.142 |
|
| 2016 |
Toogood HS, Tait S, Jervis A, Ní Cheallaigh A, Humphreys L, Takano E, Gardiner JM, Scrutton NS. Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids. Methods in Enzymology. 575: 247-70. PMID 27417932 DOI: 10.1016/Bs.Mie.2016.02.020 |
0.142 |
|
| 1999 |
Scrutton NS. Identification of covalent flavoproteins and analysis of the covalent link. Methods in Molecular Biology (Clifton, N.J.). 131: 181-93. PMID 10494550 DOI: 10.1385/1-59259-266-X:181 |
0.142 |
|
| 2011 |
Rigby SE, Lou X, Toogood HS, Wolthers KR, Scrutton NS. ELDOR spectroscopy reveals that energy landscapes in human methionine synthase reductase are extensively remodelled following ligand and partner protein binding. Chembiochem : a European Journal of Chemical Biology. 12: 863-7. PMID 21472912 DOI: 10.1002/cbic.201000630 |
0.141 |
|
| 2019 |
Klumbys E, Zebec Z, Weise NJ, Turner NJ, Scrutton NS. Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 20: 658-663. PMID 31168294 DOI: 10.1039/C7GC03325G |
0.141 |
|
| 2018 |
Toogood HS, Scrutton NS. Retooling microorganisms for the fermentative production of alcohols. Current Opinion in Biotechnology. 50: 1-10. PMID 28888164 DOI: 10.1016/j.copbio.2017.08.010 |
0.139 |
|
| 2019 |
Heyes DJ, Hardman SJO, Pedersen MN, Woodhouse J, De La Mora E, Wulff M, Weik M, Cammarata M, Scrutton NS, Schirò G. Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering. Communications Biology. 2: 1. PMID 30740537 DOI: 10.1038/s42003-018-0242-0 |
0.138 |
|
| 2001 |
Scrutton NS, Sutcliffe MJ. Trimethylamine dehydrogenase and electron transferring flavoprotein. Sub-Cellular Biochemistry. 35: 145-81. PMID 11192721 DOI: 10.1007/0-306-46828-X_5 |
0.138 |
|
| 1999 |
Lee HJ, Basran J, Lian L, Scrutton NS. Electron transfer in ω-hydroxylation: analysis of rubredoxin reductase and rubredoxin Biochemical Society Transactions. 27: A46-A46. DOI: 10.1042/BST027A046A |
0.137 |
|
| 1999 |
Basran J, Jang M, Sutcliffe MJ, Hille R, Scrutton NS. Stepwise electron transfer to 6-S cysteinyl FMN in trimethylamine dehydrogenase Biochemical Society Transactions. 27: A45-A45. DOI: 10.1042/bst027a045c |
0.136 |
|
| 2010 |
Dunn RV, Munro AW, Turner NJ, Rigby SE, Scrutton NS. Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases. Chembiochem : a European Journal of Chemical Biology. 11: 1228-31. PMID 20480485 DOI: 10.1002/cbic.201000184 |
0.133 |
|
| 2013 |
Amaral M, Outeiro TF, Scrutton NS, Giorgini F. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. Journal of Molecular Medicine (Berlin, Germany). 91: 705-13. PMID 23636512 DOI: 10.1007/S00109-013-1046-9 |
0.133 |
|
| 2021 |
Andrews F, Faulkner M, Toogood HS, Scrutton NS. Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria. Biotechnology For Biofuels. 14: 240. PMID 34920731 DOI: 10.1186/s13068-021-02091-w |
0.133 |
|
| 2018 |
Robinson CJ, Dunstan MS, Swainston N, Titchmarsh J, Takano E, Scrutton NS, Jervis AJ. Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction. Methods in Enzymology. 608: 369-392. PMID 30173770 DOI: 10.1016/bs.mie.2018.04.011 |
0.132 |
|
| 2020 |
Ramzi AB, Baharum SN, Bunawan H, Scrutton NS. Streamlining Natural Products Biomanufacturing With Omics and Machine Learning Driven Microbial Engineering. Frontiers in Bioengineering and Biotechnology. 8: 608918. PMID 33409270 DOI: 10.3389/fbioe.2020.608918 |
0.132 |
|
| 2023 |
Park H, Faulkner M, Toogood HS, Chen GQ, Scrutton N. Online Omics Platform Expedites Industrial Application of TD1.0. Bioinformatics and Biology Insights. 17: 11779322231171779. PMID 37200674 DOI: 10.1177/11779322231171779 |
0.131 |
|
| 2024 |
Park H, He H, Yan X, Liu X, Scrutton NS, Chen GQ. PHA is not just a bioplastic! Biotechnology Advances. 108320. PMID 38272380 DOI: 10.1016/j.biotechadv.2024.108320 |
0.13 |
|
| 2008 |
Hay S, Scrutton NS. Incorporation of hydrostatic pressure into models of hydrogen tunneling highlights a role for pressure-modulated promoting vibrations. Biochemistry. 47: 9880-7. PMID 18717597 DOI: 10.1021/bi8005972 |
0.129 |
|
| 2024 |
Zhang J, Yan X, Park H, Scrutton NS, Chen T, Chen GQ. Nonsterile microbial production of chemicals based on Halomonas spp. Current Opinion in Biotechnology. 85: 103064. PMID 38262074 DOI: 10.1016/j.copbio.2023.103064 |
0.128 |
|
| 2018 |
Toogood HS, Scrutton NS. Correction to “Discovery, Characterization, Engineering and Applications of Ene-Reductases for Industrial Biocatalysis” Acs Catalysis. 8: 4333-4333. DOI: 10.1021/ACSCATAL.8B01375 |
0.128 |
|
| 2006 |
Jones AR, Scrutton NS, Woodward JR. Magnetic field effects and radical pair mechanisms in enzymes: A reappraisal of the horseradish peroxidase system Journal of the American Chemical Society. 128: 8408-8409. PMID 16802800 DOI: 10.1021/ja060463q |
0.128 |
|
| 1998 |
Lee HJ, Lian LY, Scrutton NS. Recombinant two-iron rubredoxin of Pseudomonas oleovorans: overexpression, purification and characterization by optical, CD and 113Cd NMR spectroscopies. The Biochemical Journal. 131-6. PMID 9359843 DOI: 10.1042/BJ3280131 |
0.127 |
|
| 2022 |
Scrutton NS, Fujimori DG. Editorial overview: Catalysis and regulation: The chemistry of catalysis. Current Opinion in Structural Biology. 77: 102499. PMID 36371847 DOI: 10.1016/j.sbi.2022.102499 |
0.125 |
|
| 1997 |
Lee HJ, Lian LY, Scrutton NS. Rubredoxin/rubredoxin reductase of Pseudomonas oleovorans: a model system for investigating interprotein electron transfer. Biochemical Society Transactions. 24: 447S. PMID 8878991 DOI: 10.1042/BST024447S |
0.125 |
|
| 2012 |
Jones AR, Russell HJ, Greetham GM, Towrie M, Hay S, Scrutton NS. Ultrafast infrared spectral fingerprints of vitamin B12 and related cobalamins. The Journal of Physical Chemistry. A. 116: 5586-94. PMID 22612868 DOI: 10.1021/jp304594d |
0.124 |
|
| 2007 |
Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS. DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. The Journal of Biological Chemistry. 282: 30331-40. PMID 17711848 DOI: 10.1074/jbc.M703713200 |
0.122 |
|
| 2019 |
Lukinović V, Woodward JR, Marrafa TC, Shanmugam M, Heyes DJ, Hardman SJO, Scrutton NS, Hay S, Fielding AJ, Jones AR. The Photochemical Spin Dynamics of the Vitamin B Derivative, Methylcobalamin. The Journal of Physical Chemistry. B. PMID 31081330 DOI: 10.1021/acs.jpcb.9b01969 |
0.119 |
|
| 2021 |
Robinson CJ, Tellechea-Luzardo J, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Takano E, Scrutton NS. Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets. Biochemical Society Transactions. PMID 34100907 DOI: 10.1042/BST20200017 |
0.118 |
|
| 1999 |
Scrutton NS, Basran J, Wilson EK, Chohan KK, Jang MH, Sutcliffe MJ, Hille R. Electron transfer in trimethylamine dehydrogenase and electron-transferring flavoprotein Biochemical Society Transactions. 27: 196-201. PMID 10093733 DOI: 10.1042/Bst0270196 |
0.117 |
|
| 2016 |
Giachello CN, Scrutton NS, Jones AR, Baines RA. Magnetic Fields Modulate Blue-Light-Dependent Regulation of Neuronal Firing by Cryptochrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10742-10749. PMID 27798129 DOI: 10.1523/JNEUROSCI.2140-16.2016 |
0.117 |
|
| 2021 |
Jervis AJ, Hanko EKR, Dunstan MS, Robinson CJ, Takano E, Scrutton NS. A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli. Microbial Biotechnology. PMID 33710766 DOI: 10.1111/1751-7915.13780 |
0.117 |
|
| 2019 |
Sun C, Theodoropoulos C, Scrutton NS. Techno-economic assessment of microbial limonene production. Bioresource Technology. 300: 122666. PMID 31901556 DOI: 10.1016/J.Biortech.2019.122666 |
0.115 |
|
| 2017 |
Kutta RJ, Archipowa N, Johannissen LO, Jones AR, Scrutton NS. Vertebrate Cryptochromes are Vestigial Flavoproteins. Scientific Reports. 7: 44906. PMID 28317918 DOI: 10.1038/srep44906 |
0.114 |
|
| 2018 |
Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, ... ... Scrutton NS, et al. An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals. Communications Biology. 1: 66. PMID 30271948 DOI: 10.1038/s42003-018-0076-9 |
0.114 |
|
| 1997 |
Cölfen H, Harding SE, Wilson EK, Scrutton NS, Winzor DJ. Low temperature solution behaviour of Methylophilus methylotrophus electron transferring flavoprotein: A study by analytical ultracentrifugation European Biophysics Journal. 25: 411-416. DOI: 10.1007/S002490050054 |
0.113 |
|
| 2019 |
Jervis A, Carbonell P, Taylor S, Sung R, Dunstan MS, Robinson CJ, Breitling R, Takano E, Scrutton NS. SelProm: a queryable and predictive expression vector selection tool for Escherichia coli. Acs Synthetic Biology. PMID 30870592 DOI: 10.1021/acssynbio.8b00399 |
0.113 |
|
| 2011 |
Johannissen LO, Scrutton NS, Sutcliffe MJ. How does pressure affect barrier compression and isotope effects in an enzymatic hydrogen tunneling reaction? Angewandte Chemie (International Ed. in English). 50: 2129-32. PMID 21344567 DOI: 10.1002/anie.201006668 |
0.11 |
|
| 2022 |
Russell M, Currin A, Rowe W, Chen GQ, Barran P, Scrutton NS. Baseline proteomics characterisation of the emerging host biomanufacturing organism Halomonas bluephagenesis. Scientific Data. 9: 492. PMID 35963929 DOI: 10.1038/s41597-022-01610-0 |
0.108 |
|
| 2021 |
Kim Y, Bertagna F, D’Souza EM, Heyes DJ, Johannissen LO, Nery ET, Pantelias A, Sanchez-Pedreño Jimenez A, Slocombe L, Spencer MG, Al-Khalili J, Engel GS, Hay S, Hingley-Wilson SM, Jeevaratnam K, ... ... Scrutton NS, et al. Quantum Biology: An Update and Perspective Quantum Reports. 3: 80-126. DOI: 10.3390/QUANTUM3010006 |
0.106 |
|
| 2014 |
Smith CI, Convery JH, Khara B, Scrutton NS, Weightman P. Ordered multilayers of cytochrome P450 reductase adsorbed at Au(110)/phosphate buffer interfaces Physica Status Solidi (B). 252: 181-186. DOI: 10.1002/PSSB.201451221 |
0.105 |
|
| 2013 |
Levy C, Zoltowski BD, Jones AR, Vaidya AT, Top D, Widom J, Young MW, Scrutton NS, Crane BR, Leys D. Updated structure of Drosophila cryptochrome. Nature. 495: E3-4. PMID 23518567 DOI: 10.1038/Nature11995 |
0.104 |
|
| 2014 |
Marley R, Giachello CN, Scrutton NS, Baines RA, Jones AR. Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae. Scientific Reports. 4: 5799. PMID 25052424 DOI: 10.1038/srep05799 |
0.103 |
|
| 2008 |
Hay S, Pudney CR, Sutcliffe MJ, Scrutton NS. Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity? Angewandte Chemie (International Ed. in English). 47: 537-40. PMID 18058788 DOI: 10.1002/ANIE.200704484 |
0.103 |
|
| 2012 |
Russell HJ, Jones AR, Hay S, Greetham GM, Towrie M, Scrutton NS. Protein motions are coupled to the reaction chemistry in coenzyme B12-dependent ethanolamine ammonia lyase. Angewandte Chemie (International Ed. in English). 51: 9306-10. PMID 22893270 DOI: 10.1002/anie.201202502 |
0.099 |
|
| 2019 |
Currin A, Swainston N, Dunstan MS, Jervis AJ, Mulherin P, Robinson CJ, Taylor S, Carbonell P, Hollywood KA, Yan C, Takano E, Scrutton NS, Breitling R. Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries. Synthetic Biology (Oxford, England). 4: ysz025. PMID 32995546 DOI: 10.1093/synbio/ysz025 |
0.096 |
|
| 2020 |
Finnigan W, Roberts AD, Ligorio C, Scrutton NS, Breitling R, Blaker JJ, Takano E. The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers. Scientific Reports. 10: 10671. PMID 32606438 DOI: 10.1038/s41598-020-67703-1 |
0.096 |
|
| 2019 |
Roberts AD, Finnigan W, Wolde-Michael E, Kelly P, Blaker JJ, Hay S, Breitling R, Takano E, Scrutton NS. Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace. Mrs Communications. 9: 486-504. PMID 31281737 DOI: 10.1557/mrc.2019.35 |
0.093 |
|
| 2013 |
Toogood HS, Knaus T, Scrutton NS. Alternative Hydride Sources for Ene-Reductases: Current Trends Chemcatchem. 6: 951-954. DOI: 10.1002/cctc.201300911 |
0.093 |
|
| 2018 |
Zebec Z, Scrutton NS. Genome Editing for the Production of Natural Products inEscherichia coli Advanced Biosystems. 2: 1800056. DOI: 10.1002/adbi.201800056 |
0.092 |
|
| 2009 |
Woodward JR, Foster TJ, Jones AR, Salaoru AT, Scrutton NS. Time-resolved studies of radical pairs. Biochemical Society Transactions. 37: 358-62. PMID 19290862 DOI: 10.1042/BST0370358 |
0.087 |
|
| 2020 |
Smith CI, Convery JH, Khara B, Scrutton NS, Weightman P. The influence of the structure of the Au(110) surface on the ordering of a monolayer of cytochrome P450 reductase at the Au(110)/phosphate buffer interface. Physica Status Solidi. B, Basic Solid State Physics : Pss. 251: 549-554. PMID 27630536 DOI: 10.1002/pssb.201350063 |
0.086 |
|
| 2015 |
Scrutton NS. Professor Richard Nelson Perham. The Febs Journal. 282: 1349-51. PMID 25866144 DOI: 10.1111/febs.13273 |
0.086 |
|
| 2015 |
Coe BJ, Helliwell M, Raftery J, Sánchez S, Peers MK, Scrutton NS. Cyclometalated Ir(iii) complexes of deprotonated N-methylbipyridinium ligands: effects of quaternised N centre position on luminescence. Dalton Transactions (Cambridge, England : 2003). PMID 26503369 DOI: 10.1039/c5dt03753k |
0.083 |
|
| 2018 |
Swainston N, Dunstan M, Jervis AJ, Robinson CJ, Carbonell P, Williams AR, Faulon JL, Scrutton NS, Kell DB. PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts. Bioinformatics (Oxford, England). 34: 2327-2329. PMID 29949952 DOI: 10.1093/bioinformatics/bty105 |
0.081 |
|
| 2015 |
Peers MK, Toogood HS, Heyes DJ, Mansell D, Coe BJ, Scrutton NS. Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers Catalysis Science and Technology. 6: 169-177. DOI: 10.1039/c5cy01642h |
0.079 |
|
| 2020 |
Carbonell P, Le Feuvre R, Takano E, Scrutton NS. design and automated learning to boost next-generation smart biomanufacturing. Synthetic Biology (Oxford, England). 5: ysaa020. PMID 33344778 DOI: 10.1093/synbio/ysaa020 |
0.075 |
|
| 2019 |
Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, ... ... Scrutton NS, et al. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Communications Biology. 2: 271. PMID 31372510 DOI: 10.1038/s42003-019-0520-5 |
0.075 |
|
| 2021 |
Collier MEW, Zhang S, Scrutton NS, Giorgini F. Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition? Drug Discovery Today. PMID 33609782 DOI: 10.1016/j.drudis.2021.02.009 |
0.074 |
|
| 2018 |
Nampi PP, Vakurov A, Mackenzie LE, Scrutton NS, Millner PA, Jose G, Saha S. Selective cellular imaging with lanthanide based upconversion nanoparticles. Journal of Biophotonics. e201800256. PMID 30350344 DOI: 10.1002/jbio.201800256 |
0.073 |
|
| 2018 |
Choudry U, Heyes DJ, Hardman SJO, Sakuma M, Sazanovich IV, Woodhouse J, Mora EDL, Pedersen MN, Wulff M, Weik M, Schirò G, Scrutton NS. Front Cover: Photochemical Mechanism of an Atypical Algal Phytochrome (ChemBioChem 10/2018) Chembiochem. 19: 997-997. DOI: 10.1002/Cbic.201800204 |
0.073 |
|
| 2015 |
Coe BJ, Helliwell M, Sánchez S, Peers MK, Scrutton NS. Water-soluble Ir(iii) complexes of deprotonated N-methylbipyridinium ligands: fluorine-free blue emitters. Dalton Transactions (Cambridge, England : 2003). 44: 15420-3. PMID 26267300 DOI: 10.1039/c5dt02591e |
0.071 |
|
| 2020 |
Zhang S, Collier MEW, Heyes DJ, Giorgini F, Scrutton NS. Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases. Archives of Biochemistry and Biophysics. 108702. PMID 33275878 DOI: 10.1016/j.abb.2020.108702 |
0.069 |
|
| 2019 |
Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, ... ... Scrutton NS, et al. Building a global alliance of biofoundries. Nature Communications. 10: 2040. PMID 31068573 DOI: 10.1038/S41467-019-10079-2 |
0.068 |
|
| 2008 |
Munro AW, Dunford AJ, Hay S, Heyes DJ, Quinn A, Rigby SE, Scrutton NS. O21. Ca2+-calmodulin exerts thermodynamic and conformational regulation over electron transport in nNOS Nitric Oxide. 19: 24-25. DOI: 10.1016/J.NIOX.2008.06.022 |
0.066 |
|
| 2018 |
Le Feuvre RA, Scrutton NS. A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials. Synthetic and Systems Biotechnology. 3: 105-112. PMID 29900423 DOI: 10.1016/j.synbio.2018.04.002 |
0.065 |
|
| 2021 |
Wolde-Michael E, Roberts AD, Heyes DJ, Dumanli AG, Blaker JJ, Takano E, Scrutton NS. Design and fabrication of recombinant reflectin-based multilayer reflectors: bio-design engineering and photoisomerism induced wavelength modulation. Scientific Reports. 11: 14580. PMID 34272457 DOI: 10.1038/s41598-021-94042-6 |
0.064 |
|
| 2019 |
Ahmed ST, Leferink NG, Scrutton NS. Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers Molecular Catalysis. 467: 95-110. DOI: 10.1016/J.MCAT.2019.01.036 |
0.062 |
|
| 2012 |
Toogood HS, Mansell D, Gardiner JM, Scrutton NS. 7.11 Reduction: Enantioselective Bioreduction of C-C Double Bonds Comprehensive Chirality. 7: 216-255. DOI: 10.1016/B978-0-08-095167-6.00713-8 |
0.056 |
|
| 2015 |
Coe BJ, Peers MK, Scrutton NS. Syntheses and electronic and optical properties of complexes of the bis(2,2′-bipyrazyl)ruthenium unit Polyhedron. 96: 57-65. DOI: 10.1016/j.poly.2015.04.028 |
0.055 |
|
| 2015 |
Chaiyen P, Scrutton NS. Special Issue: Flavins and Flavoproteins: Introduction. The Febs Journal. 282: 3001-2. PMID 26096566 DOI: 10.1111/febs.13337 |
0.055 |
|
| 2020 |
Roberts AD, Lee JM, Magaz A, Smith MW, Dennis M, Scrutton NS, Blaker JJ. Hierarchically Porous Silk/Activated-Carbon Composite Fibres for Adsorption and Repellence of Volatile Organic Compounds. Molecules (Basel, Switzerland). 25. PMID 32156015 DOI: 10.3390/molecules25051207 |
0.051 |
|
| 2015 |
Coe BJ, Helliwell M, Sánchez S, Peers MK, Scrutton NS. Water-soluble Ir(III) complexes of deprotonated N-methylbipyridinium ligands: Fluorine-free blue emitters Dalton Transactions. 44: 15420-15423. DOI: 10.1039/c5dt02591e |
0.047 |
|
| 2015 |
Coe BJ, Peers MK, Raftery J, Scrutton NS. Crystal structure of [1,1'''-bis-(pyrimidin-2-yl)-4,4':2',2'':4'',4'''-quaterpyridine-1,1'''-diium-κ(2) N (1'),N (1'')]bis-[2-(pyridin-2-yl)phenyl-κ(2) N,C (1)]iridium(III) tris-(hexa-fluorido-phosphate) aceto-nitrile tris-olvate. Acta Crystallographica. Section E, Crystallographic Communications. 71: 879-82. PMID 26396745 DOI: 10.1107/S2056989015012463 |
0.045 |
|
| 2020 |
Leys D, Scrutton NS. Flavin doesn't put all oxygens in one basket. Nature Chemical Biology. 16: 485-486. PMID 32322093 DOI: 10.1038/s41589-020-0523-z |
0.044 |
|
| 2019 |
Roberts AD, Kelly P, Bain J, Morrison JJ, Wimpenny I, Barrow M, Woodward RT, Gresil M, Blanford C, Hay S, Blaker JJ, Yeates SG, Scrutton NS. Graphene-aramid nanocomposite fibres via superacid co-processing. Chemical Communications (Cambridge, England). PMID 31509114 DOI: 10.1039/C9Cc04548A |
0.03 |
|
| 2019 |
Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, ... ... Scrutton NS, et al. Author Correction: Building a global alliance of biofoundries. Nature Communications. 10: 3132. PMID 31296848 DOI: 10.1038/S41467-019-10862-1 |
0.027 |
|
| 2021 |
Heyes DJ, Zhang S, Taylor A, Johannissen LO, Hardman SJO, Hay S, Scrutton NS. Publisher Correction: Photocatalysis as the 'master switch' of photomorphogenesis in early plant development. Nature Plants. PMID 33837366 DOI: 10.1038/s41477-021-00911-3 |
0.02 |
|
| 2018 |
Scrutton N. Preface. Methods in Enzymology. 608: xvii-xviii. PMID 30173776 DOI: 10.1016/S0076-6879(18)30341-0 |
0.01 |
|
| Hide low-probability matches. |