Simon G. Patching - Publications

Affiliations: 
1998- University of Leeds, Leeds, England, United Kingdom 
Area:
Membrane Proteins, Protein Structure and Function, Antimicrobial Resistance, Infectious Diseases, Chemistry, Biochemistry, Microbiology, Structural Biology, Biophysics, NMR

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nawaz N, Ali R, Ali M, Manfield IW, Taj MK, Mustafa MZ, Patching SG. Microscale Thermophoresis Analysis of Membrane Proteins Chemical Science International Journal. 33: 25-45. DOI: 10.9734/CSJI/2024/v33i2887  0.266
2024 Nawaz N, Patching SG. Polarising Agents and Spin Tags Used in DNP-ssNMR Studies on Biological Samples: An Update Innovations in Biological Science. 2: 123-164. DOI: 10.9734/bpi/ibs/v2/8303E  0
2024 Nawaz N, Ali R, Ali M, Manfield IW, Taj MK, Mustafa MZ, Patching SG. Microscale Thermophoresis Analysis of Membrane Proteins Osf Preprints. 1-17. DOI: 10.31219/osf.io/pe7ut  0.461
2023 Nawaz N, Patching SG. Polarising Agents and Spin Tags for Dynamic Nuclear Polarisation (DNP)-Enhanced Solid-State Nuclear Magnetic Resonance (ssNMR) Analysis of Biological Samples Current Journal of Applied Science and Technology. 42: 11-38. DOI: 10.9734/cjast/2023/v42i284197  0.226
2023 Nawaz N, Patching SG. Polarising Agents and Spin Tags for Dynamic Nuclear Polarisation (DNP)-Enhanced Solid-State Nuclear Magnetic Resonance (ssNMR) Analysis of Biological Samples Osf Prerints. 1-26. DOI: 10.31219/osf.io/pyjuk  0.226
2023 Sun L, Patching SG. Elevator mechanism of alternating access in the Escherichia coli concentrative nucleoside transporter NupC Biorxiv. 2023.02.03.527023. DOI: 10.1101/2023.02.03.527023  0.37
2023 Sun L, Patching SG. Elevator mechanism of alternating access in the Escherichia coli concentrative nucleoside transporter NupC International Journal of Advanced Multidisciplinary Research and Studies. 3: 888-910.  0.37
2022 Basnet S, Marahatha R, Shrestha A, Bhattarai S, Katuwal S, Sharma KR, Marasini BP, Dahal SR, Basnyat RC, Patching SG, Parajuli N. In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein. Molecules (Basel, Switzerland). 27. PMID 36558090 DOI: 10.3390/molecules27248957  0.375
2022 Basnet S, Marahatha R, Shrestha A, Bhattarai S, Katuwal S, Sharma KR, Marasini BP, Dahal SR, Basnyat RC, Patching SG, Parajuli N. In Vitro and In Silico Studies for the Identification of Potent Metabolites of Some High-Altitude Medicinal Plants from Nepal Inhibiting SARS-CoV-2 Spike Protein. Molecules (Basel, Switzerland). 27. PMID 36558090 DOI: 10.3390/molecules27248957  0.375
2022 Nadar S, Khan T, Patching SG, Omri A. Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance. Microorganisms. 10. PMID 35208758 DOI: 10.3390/microorganisms10020303  0.282
2022 Ahmad I, Ali M, Ali R, Nawaz N, Patching SG. Structure-based virtual screening and molecular docking of drugs against the SARS-CoV-2 spike protein-ACE2 receptor complex Pakistan Journal of Pharmaceutical Sciences. 35: 1531-1538. DOI: 10.36721/PJPS.2022.35.6.REG.1531-1538.1  0.305
2022 Patching SG. Spermidine binding to the Acetinobacter baumannii efflux protein AceI observed by near-UV synchrotron radiation circular dichroism spectroscopy Radiation. 2: 228-233. DOI: 10.3390/radiation2020016  0.357
2022 Nadar S, Khan T, Patching SG, Omri A. Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance Microorganisms. 10: 303. DOI: 10.3390/microorganisms10020303  0.224
2022 Ahmad I, Hassan KA, Henderson PJF, Patching SG. Cloning, amplified expression, functional characterisation and purification of a Pseudomonas putida NCS1 family transport protein International Journal of Advanced Multidisciplinary Research. 9: 127-156. DOI: 10.22192/ijamr.2022.09.12.01  0.408
2022 Patching SG. Spermidine binding to the Acetinobacter baumannii efflux protein AceI observed by near-UV synchrotron radiation circular dichroism spectroscopy Preprints. 2022010108: 1-5. DOI: 10.20944/preprints202201.0108.v1  0.357
2022 Zia-Ud-Din, Aftab MN, Kakar NH, Mustafa MZ, Zafar A, Iqbal I, Ahmad I, Patching SG, Khan MA, Asmat TM, Shafee M, Rafeeq M. Comparative effects of Bacillus probiotic and antibiotic on the growth performance of indigenous Aseel chickens International Journal of Agriculture and Biological Sciences. 4: 37-45.  0.215
2021 Rabail R, Saleem J, Tanveer Z, Patching SG, Khalid AR, Sultan MT, Manzoor MF, Karrar E, Inam-Ur-Raheem M, Shabbir MA, Aadil RM. Nutritional and lifestyle changes required for minimizing the recovery period in home quarantined COVID-19 patients of Punjab, Pakistan. Food Science & Nutrition. PMID 34518779 DOI: 10.1002/fsn3.2458  0.226
2021 Tayyeb M, Rashid N, Kakar NH, Taj MK, Abbasi BHA, Ahmad I, Patching SG, Kakar H, Mustafa MZ. Microbial and Nutritional Evaluation of Fresh and Wastewater Cultivated Cabbage in Quetta, Pakistan International Journal of Environmental & Agriculture Research. 7: 15-19. DOI: 10.5281/zenodo.4877642  0.202
2021 Nawaz N, Ahmad I, Patching SG, Hussain I. Green synthesis of gold nanoparticles using Tribulus terrestris extract and antibacterial activity against Gram-negative bacteria Biomedical Letters. 7: 80-89. DOI: 10.47262/BL/7.2.20210617  0.224
2021 Ahmad I, Lee Y, Nawaz N, Elahi R, Khan IA, Mustafa MZ, Patching SG. Cloning, amplified expression and bioinformatics analysis of a putative Nucleobase Cation Symporter-1 (NCS-1) protein from Rhodococcus erythropolis Bioscientific Review. 3: 54-71. DOI: 10.32350//BSR.0304.05  0.357
2021 Ahmad I, Khattak S, Ali R, Nawaz N, Ullah K, Khan SB, Ali M, Patching SG, Mustafa MZ. Prevalence and molecular characterization of multidrug-resistant Escherichia coli O157: H7 from dairy milk in the Peshawar region of Pakistan Journal of Food Safety. DOI: 10.1111/jfs.12941  0.273
2021 Rabail R, Saleem J, Tanveer Z, Patching SG, Khalid AR, Sultan MT, Manzoor MF, Karrar E, Inam-Ur-Raheem M, Shabbir MA, Aadil RM. Nutritional and lifestyle changes required for minimizing the recovery period in home quarantined COVID‐19 patients of Punjab, Pakistan Food Science & Nutrition. 9: 5036-5059. DOI: 10.1002/fsn3.2458  0.18
2021 Patching SG, Martins M, Murakami S, Yan A, Nishino K, Law CJ, Nandanwar HS, Bay DC. Structure, Function, and Regulation of Bacterial Efflux Proteins in Metal Homeostasis and Antimicrobial Resistance (Editorial) Front Mol Biosci 0.349
2021 Patching SG. Bacterial Multidrug Efflux Proteins in Antimicrobial Resistance (Editorial) Antibiotics 0.349
2020 Ali R, Jiao Y, Wall PK, Patching SG, Ahmad I, Lutfulla G, dePamphilis CW. In silico identification and structure function analysis of a putative coclaurine N-methyltransferase from Aristolochia fimbriata Comput Biol Chem. 85: 107201. PMID 31986303 DOI: 10.1016/j.compbiolchem.2020.107201  0.339
2020 Ali R, Jiao Y, Kerr Wall P, Patching SG, Ahmad I, Lutfulla G, dePamphilis CW. In silico identification and structure function analysis of a putative coclaurine N-methyltransferase from Aristolochia fimbriata. Computational Biology and Chemistry. 85: 107201. PMID 31986303 DOI: 10.1016/J.Compbiolchem.2020.107201  0.604
2020 Jehan M, Bajwa MA, Tariq MM, Eyduran E, Rafeeq M, Mustafa MZ, Ahmad I, Patching SG, Waheed A, Ahmad J, Khan MA, Ahmad F, Fatih A, Ali I, Ahmed M, et al. Unique characteristics, biometric measurements, management and performance parameters of Balochi sheep International Journal of Agriculture and Biological Sciences. 5: 1-6. DOI: 10.5281/zenodo.4283497  0.179
2020 Ahmad I, Nawaz N, Dermani FK, Kohlan AK, Saidijam M, Patching SG. Bacterial multidrug efflux proteins: A major mechanism of antimicrobial resistance Curr Drug Targets. DOI: 10.2174/1389450119666180426103300  0.774
2020 Sun L, Xie H, Ingram JC, Hope RJ, Baldwin SA, Patching SG. Characterization of the Escherichia coli concentrative nucleoside transporter NupC using computational, biochemical and biophysical methods Biochemistry. DOI: 10.1021/acs.biochem.7b00172  0.362
2020 Nawaz N, Ahmad I, Darwesh NM, Wahab A, ur Rahman S, Sajid A, Khan FA, Khan SB, Patching SG, Uddin K. Synthesis, characterization and antioxidant activity of Nickel(II) Schiff base complexes derived from 4-(dimethylamino)benzaldehyde J Chem Soc Pak. 42: 238-242.  0.221
2020 Robajac D, Šunderić M, Gligorijević N, Nedić O, Tingey M, Schnell SJ, Li Y, Junod S, Yu W, Yang W, Roy NK, Beckstein O, Naughton F, Lu M, Lu KS-J, ... ... Patching SG, et al. A Closer Look at Membrane Proteins Independent Publishing Network, Isbn: 978-1-83853-535-3. 1-350.  0.463
2020 Ahmad I, Ma P, Nawaz N, Sharples DJ, Henderson PJF, Patching SG. Cloning, amplified expression, functional characterisation and purification of Vibrio parahaemolyticus NCS1 cytosine transporter VPA1242 A Closer Look At Membrane Proteins. Independent Publishing Network, Isbn: 978-1-83853-535-3. 241-267.  0.355
2019 Shafee M, Abbas F, Tanveer Z, Whitelaw A, Tow LA, Ashraf M, Ahmad I, Patching SG, Jabbar A, Akbar A, Mustafa MZ. Predominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotyping J Infect Dev Ctries. 13: 619-625. PMID 32065819 DOI: 10.3855/jidc.10803  0.206
2019 Shafee M, Abbas F, Tanveer Z, Whitelaw A, Tow LA, Ashraf M, Ahmad I, Patching SG, Jabbar A, Akbar A, Mustafa MZ. Predominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotyping. Journal of Infection in Developing Countries. 13: 619-625. PMID 32065819 DOI: 10.3855/Jidc.10803  0.526
2019 Samad A, Abbas F, Tanveer Z, Ahmad Z, Ahmad I, Patching SG, Nawaz N, Asmat MT, Raziq A, Asasullah, Sheikh IS, Naeem M, Pokryshko O, Mustafa MZ. Prevalence of Salmonella spp. in chicken meat from Quetta retail outlets and typing through multiplex PCR Rom Biotech Lett. 24: 271-279. DOI: 10.25083/Rbl/24.2/271.279  0.735
2019 Hassan KA, Naidu V, Edgerton JR, Mettrick KA, Liu Q, Fahmy L, Li L, Jackson SM, Ahmad I, Sharples D, Patching SG, Henderson PJF, Paulsen IT. Short-chain diamines are the physiological substrates of PACE family efflux pumps Proc Natl Acad Sci U S A. 116: 18015-18020.  0.242
2018 Patching SG. Recent developments in Nucleobase Cation Symporter-1 (NCS1) family transport proteins from bacteria, archaea, fungi and plants J Biosci. 43: 797-815. PMID 30207323 DOI: 10.1007/S12038-018-9780-3  0.541
2018 Ahmad I, Nawaz N, Dermani FK, Kohlan AK, Saidijam M, Patching SG. Bacterial Multidrug Efflux Proteins: A Major Mechanism of Antimicrobial Resistance. Current Drug Targets. PMID 29697028 DOI: 10.2174/1389450119666180426103300  0.638
2018 Ahmad I, Nawaz N, Darwesh NM, ur Rahman S, Mustafa MZ, Khan SB, Patching SG. Overcoming challenges for amplified expression of recombinant proteins using Escherichia coli Protein Expr Purif. 144: 12-18. PMID 29180019 DOI: 10.1016/j.pep.2017.11.005  0.372
2018 Saidijam M, Karimi Dermani F, Sohrabi S, Patching SG. Efflux proteins at the blood-brain barrier: review and bioinformatics analysis Xenobiotica. 48: 506-532. PMID 28481715 DOI: 10.1080/00498254.2017.1328148  0.465
2018 Saidijam M, Azizpour S, Patching SG. Comprehensive analysis of the numbers, lengths and amino acid compositions of transmembrane helices in prokaryotic, eukaryotic and viral integral membrane proteins of high-resolution structure J Biomol Struct Dyn. 36: 443-464. PMID 28150531 DOI: 10.1080/07391102.2017.1285725  0.48
2018 Saidijam M, Afshar S, Ahmad I, Patching SG. Nucleoside transporters in PET imaging of proliferating cancer cells using 3'-deoxy-3'-[18F]fluoro-L-thymidine Journal of Diagnostic Imaging in Therapy. 5: 1-13. DOI: 10.17229/jdit.2018-0210-030  0.503
2018 Samad A, Abbas F, Ahmad Z, Tanveer Z, Ahmad I, Patching SG, Nawaz N, Asmat MT, Raziq A, Asadullah, Naeem M, Akhtar MA, Pokryshko O, Mustafa MZ. Multiplex polymerase chain reaction detection of Shiga toxin genes and antibiotic sensitivity of E. coli O157:H7 isolated from beef meat in Quetta, Pakistan J Food Safety. 38: e12540. DOI: 10.1111/Jfs.12540  0.749
2018 Ahmad I, Nawaz N, Ur Rahman S, Sajid A, Khan FA, Khan SB, Mustafa MZ, Patching SG. Multifaceted roles of efflux proteins in prokaryotes Ajbls. 7: 1-7.  0.385
2017 Ahmad I, Nawaz N, Darwesh NM, Ur Rahman S, Mustafa MZ, Khan SB, Patching SG. Overcoming challenges for amplified expression of recombinant proteins using Escherichia coli. Protein Expression and Purification. 144: 12-18. PMID 29180019 DOI: 10.1016/J.Pep.2017.11.005  0.78
2017 Sun L, Xie H, Ingram JC, Hope RJ, Baldwin SA, Patching SG. Characterisation of the Escherichia coli Concentrative Nucleoside Transporter NupC Using Computational, Biochemical and Biophysical Methods. Biochemistry. PMID 28682624 DOI: 10.1021/Acs.Biochem.7B00172  0.823
2017 Phillips-Jones MK, Channell G, Kelsall CJ, Hughes CS, Ashcroft AE, Patching SG, Dinu V, Gillis RB, Adams GG, Harding SE. Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin Sci Rep. 7: 46180. PMID 28397853 DOI: 10.1038/srep46180  0.341
2017 Phillips-Jones MK, Channell G, Kelsall CJ, Hughes CS, Ashcroft AE, Patching SG, Dinu V, Gillis RB, Adams GG, Harding SE. Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin. Scientific Reports. 7: 46180. PMID 28397853 DOI: 10.1038/Srep46180  0.434
2017 Rahman M, Ismat F, Jiao L, Baldwin JM, Sharples DJ, Baldwin SA, Patching SG. Characterisation of the DAACS family Escherichia coli glutamate/aspartate-proton symporter GltP using computational, chemical, biochemical and biophysical methods J Membr Biol. 250: 145-162. PMID 28025687 DOI: 10.1007/s00232-016-9942-x  0.497
2017 Saidijam M, Azizpour S, Patching SG. Amino acid composition analysis of human secondary transport proteins and implications for reliable membrane topology prediction J Biomol Struct Dyn. 35: 929-949. PMID 27159787 DOI: 10.1080/07391102.2016.1167622  0.538
2017 Patching SG. Glucose transporters at the blood-brain barrier: Function, regulation and gateways for drug delivery Mol Neurobiol. 54: 1046-1077. PMID 26801191 DOI: 10.1007/S12035-015-9672-6  0.4
2017 Patching SG. Synthesis, NMR analysis and applications of isotope-labelled hydantoins Journal of Diagnostic Imaging in Therapy. 4: 3-26. DOI: 10.17229/jdit.2017-0225-026  0.254
2016 Rahman M, Ismat F, Jiao L, Baldwin JM, Sharples DJ, Baldwin SA, Patching SG. Characterisation of the DAACS Family Escherichia coli Glutamate/Aspartate-Proton Symporter GltP Using Computational, Chemical, Biochemical and Biophysical Methods. The Journal of Membrane Biology. PMID 28025687 DOI: 10.1007/S00232-016-9942-X  0.826
2016 Hussain R, Harding SE, Hughes CS, Ma P, Patching SG, Edara S, Siligardi G, Henderson PJ, Phillips-Jones MK. Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions Biochem Soc Trans. 44: 810-823. PMID 27284046 DOI: 10.1042/BST20160023  0.479
2016 Hussain R, Harding SE, Hughes CS, Ma P, Patching SG, Edara S, Siligardi G, Henderson PJ, Phillips-Jones MK. Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions. Biochemical Society Transactions. 44: 810-23. PMID 27284046 DOI: 10.1042/Bst20160023  0.794
2016 Ma P, Patching SG, Ivanova E, Baldwin JM, Sharples D, Baldwin SA, Henderson PJ. Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity Microbiology. 162: 823-836. PMID 26967546 DOI: 10.1099/mic.0.000266  0.572
2016 Ma P, Patching SG, Ivanova E, Baldwin JM, Sharples D, Baldwin SA, Henderson PJ. Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity. Microbiology (Reading, England). 162: 823-36. PMID 26967546 DOI: 10.1099/Mic.0.000266  0.849
2016 Hiruma-Shimizu K, Shimizu H, Thompson GS, Kalverda AP, Patching SG. Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications. Molecular Membrane Biology. 1-17. PMID 26906947 DOI: 10.3109/09687688.2015.1125536  0.808
2016 Hiruma-Shimizu K, Shimizu H, Thompson GS, Kalverda AP, Patching SG. Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications Molecular Membrane Biology. 1-17. DOI: 10.3109/09687688.2015.1125536  0.444
2016 Patching SG. NMR-active nuclei for biological and biomedical applications Journal of Diagnostic Imaging in Therapy. 3: 7-48. DOI: 10.17229/jdit.2016-0618-021  0.253
2016 Ma P, Patching SG, Ivanova E, Baldwin JM, Sharples D, Baldwin SA, Henderson PJF. Allantoin transport protein, Pucl, from Bacillus subtilis: Evolutionary relationships, amplified expression, activity and specificity Microbiology (United Kingdom). 162: 823-836. DOI: 10.1099/mic.0.000266  0.819
2016 Saidijam M, Azizpour S, Patching SG. Amino acid composition analysis of human secondary transport proteins and implications for reliable membrane topology prediction Journal of Biomolecular Structure and Dynamics. 1-21. DOI: 10.1080/07391102.2016.1167622  0.461
2015 Hiruma-Shimizu K, Shimizu H, Thompson GS, Kalverda AP, Patching SG. Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications Mol Membr Biol. 32: 139-155. PMID 26906947 DOI: 10.3109/09687688.2015.1125536  0.478
2015 Patching SG. Solid-state NMR structures of integral membrane proteins Mol Membr Biol. 32: 156-178. PMID 26857803 DOI: 10.3109/09687688.2016.1139754  0.518
2015 Saidijam M, Patching SG. Amino acid composition analysis of secondary transport proteins from Escherichia coli with relation to functional classification, ligand specificity and structure J Biomol Struct. 33: 2205-2220. PMID 25586792 DOI: 10.1080/07391102.2014.998283  0.517
2015 Whittaker CA, Patching SG, Esmann M, Middleton DA. Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement Org Biomol Chem. 13: 2664-2668. PMID 25582619 DOI: 10.1039/c4ob02427c  0.428
2015 Whittaker CAP, Patching SG, Esmann M, Middleton DA. Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement Organic and Biomolecular Chemistry. 13: 2664-2668. PMID 25582619 DOI: 10.1039/C4Ob02427C  0.508
2015 Patching SG. Roles of facilitative glucose transporter GLUT1 in [18F]FDG positron emission tomography (PET) imaging of human diseases Journal of Diagnostic Imaging in Therapy. 2: 30-102. DOI: 10.17229/jdit.2015-0301-014  0.242
2014 Hiruma-Shimizu K, Kalverda AP, Henderson PJ, Homans SW, Patching SG. Synthesis of uniformly deuterated n-dodecyl-β-D-maltoside (d39-DDM) for solubilization of membrane proteins in TROSY NMR experiments J Labelled Comp Radiopharm. 57: 737-743. PMID 25491565 DOI: 10.1002/jlcr.3249  0.406
2014 Hiruma-Shimizu K, Kalverda AP, Henderson PJF, Homans SW, Patching SG. Synthesis of uniformly deuterated n-dodecyl-β -d-maltoside (d39 -DDM) for solubilization of membrane proteins in TROSY NMR experiments Journal of Labelled Compounds and Radiopharmaceuticals. 57: 737-743. PMID 25491565 DOI: 10.1002/Jlcr.3249  0.786
2014 Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, et al. Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 Embo J. 33: 1831-1844. PMID 24952894 DOI: 10.15252/embj.201387557  0.499
2014 Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, et al. Molecular mechanism of ligand recognition by membrane transport protein, Mhp1. The Embo Journal. 33: 1831-44. PMID 24952894 DOI: 10.15252/Embj.201387557  0.823
2014 Kalverda AP, Gowdy J, Thompson GS, Homans SW, Henderson PJ, Patching SG. TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor Mol Membr Biol. 31: 131-140. PMID 24804563 DOI: 10.3109/09687688.2014.911980  0.482
2014 Kalverda AP, Gowdy J, Thompson GS, Homans SW, Henderson PJ, Patching SG. TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor. Molecular Membrane Biology. 31: 131-40. PMID 24804563 DOI: 10.3109/09687688.2014.911980  0.82
2014 Siligardi G, Hussain R, Patching SG, Phillips-Jones MK. Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy Biochim Biophys Acta – Biomembranes. 1838: 34-42. PMID 23811229 DOI: 10.1016/J.Bbamem.2013.06.019  0.566
2014 Patching SG. Surface plasmon resonance spectroscopy for characterisation of membrane protein-ligand interactions and its potential for drug discovery Biochim Biophys Acta – Biomembranes. 1838: 43-55. PMID 23665295 DOI: 10.1016/J.Bbamem.2013.04.028  0.516
2014 Jackson SM, Patching SG, Hassan KA, Sharples DJ, Paulsen IT, Hussain R, Siligardi G, Henderson PJF. Tackling bacterial resistance to antiseptics Diamond Light Source Annual Report 0.252
2013 Hassan KA, Jackson SM, Penesyan A, Patching SG, Tetu SG, Eijkelkamp BA, Brown MH, Henderson PJ, Paulsen IT. Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins Proc Natl Acad Sci U S A. 110: 20254-20259. PMID 24277845 DOI: 10.1073/pnas.1317052110  0.482
2013 Hassan KA, Jackson SM, Penesyan A, Patching SG, Tetu SG, Eijkelkamp BA, Brown MH, Henderson PJ, Paulsen IT. Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 20254-9. PMID 24277845 DOI: 10.1073/Pnas.1317052110  0.785
2013 Phillips-Jones MK, Patching SG, Edara S, Nakayama J, Hussain R, Siligardi G. Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism Phys Chem Chem Phys. 15: 444-447. PMID 23183669 DOI: 10.1039/C2Cp43722H  0.775
2013 Patching SG, Henderson PJ, Sharples DJ, Middleton DA. Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR Mol Membr Biol. 30: 129-137. PMID 23173920 DOI: 10.3109/09687688.2012.743193  0.421
2013 Patching SG, Henderson PJF, Sharples DJ, Middleton DA. Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR Molecular Membrane Biology. 30: 129-137. PMID 23173920 DOI: 10.3109/09687688.2012.743193  0.502
2013 Bettaney KE, Sukumar P, Hussain R, Siligardi G, Henderson PJ, Patching SG. A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis Mol Membr Biol. 30: 3-14. PMID 23078035 DOI: 10.3109/09687688.2012.729093  0.52
2013 Bettaney KE, Sukumar P, Hussain R, Siligardi G, Henderson PJF, Patching SG. A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis Molecular Membrane Biology. 30: 3-14. PMID 23078035 DOI: 10.3109/09687688.2012.729093  0.83
2013 Phillips-Jones MK, Patching SG, Edara S, Nakayama J, Hussain R, Siligardi G. Investigation of the first step of a virulence regulatory pathway in a bacterial hospital-acquired infection agent Diamond Light Source Annual Report 0.222
2013 Phillips-Jones MK, Patching SG, Edara S, Nakayama J, Hussain R, Siligardi G. Applications of synchrotron radiation circular dichroism (SRCD) for studies of ligand and inhibitor interactions with membrane protein targets: investigations of the FsrC quorum membrane sensor kinase Society For General Microbiology Spring Meeting 0.412
2013 Patching SG, Edara S, Nakayama J, Phillips-Jones MK. Investigation of FsrC ligand binding, the first step in the Fsr quorum signalling pathway in Enterococcus faecalis 17th International Conference On Bacilli and 7th Conference On Functional Genomics of Gram Positive Microorganisms 0.272
2013 Jackson SM, Patching SG, Ivanova E, Simmons KJ, Weyand S, Shimamura T, Brueckner F, Suzuki S, Iwata S, Sharples DJ, Baldwin SA, Sansom MPS, Beckstein O, Cameron A, Henderson PJF. Mhp1, the Na+-hydantoin membrane transport protein In Roberts Gck (Ed) Encyclopedia of Biophysics, Springer. 1514-1521.  0.502
2013 Middleton DA, Patching SG. Solid-state NMR spectroscopy in drug design and discovery In: Andrushko V, Andrushko N, Eds. Stereoselective Synthesis of Drugs and Natural Products. Chichester, Uk: John Wiley & Sons, Ltd 0.235
2013 Patching SG, Jackson SM, Polyakova A, Bettaney KE, Sukumar P, Edara S, Phillips-Jones MK, Henderson PJF, Hussain R, Siligardi G. SRCD analysis of perpetual membrane proteins from bacteria Diamond Light Source Ltd, Circular Dichroism Beamline B23 Roadshow Series: Membrane Protein and Carbohydrate Research Workshop. the Metropole Hotel, Leeds 0.473
2012 Patching SG, Edara S, Ma P, Nakayama J, Hussain R, Siligardi G, Phillips-Jones MK. Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed through synchrotron radiation circular dichroism Biochim Biophys Acta – Biomembranes. 1818: 1595-1602. PMID 22366202 DOI: 10.1016/J.Bbamem.2012.02.015  0.8
2012 Aigbirhio F, Appleyard MVCL, Arrowsmith RL, Baldwin SA, Bayrakdarian M, Botting NP, Cantin LD, Carbery DR, Carroll MA, Dixon LI, Dorff PN, Ellames G, Elmore CS, Fishwick CWG, Foot O, ... ... Patching SG, et al. Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011 Journal of Labelled Compounds and Radiopharmaceuticals. 55: 125-134. DOI: 10.1002/Jlcr.2907  0.738
2012 Patching SG. Structure-function investigation of membrane proteins. European Drug Initiative on Channels and Transporters (EDICT) General Assembly, Tavira, Portugal 0.437
2012 Patching SG, Jacobs TM. Crystal structure of L-5-indolylmethylhydantoin Private Communication to the Cambridge Structural Database, Deposition Numbers Ccdc 865285 and 865286 0.226
2012 Patching SG, Jackson S, Simmons KJ, Ma P, Baldwin SA, Johnson AP, Fishwick CWG, Henderson PJF. Isotope chemistry for investigating ligand binding and transport by Mhp1 and its homologues J Labelled Comp Radiopharm. 55: 132.  0.376
2012 Patching SG, Middleton DA, Kalverda AP, Gowdy J, Baldwin SA, Phillips-Jones MK, Levitt MH, Homans SW, Henderson PJF. NMR methods for structure-function investigation of membrane proteins and their ligands J Labelled Comp Radiopharm. 55: 132-133.  0.451
2011 Patching SG. NMR structures of polytopic integral membrane proteins Mol Membr Biol. 28: 370-397. PMID 21809901 DOI: 10.3109/09687688.2011.603100  0.565
2011 Patching SG. Efficient syntheses of 13C- and 14C-labelled 5-benzyl and 5-indolylmethyl L-hydantoins J Labelled Comp Radiopharm. 54: 110-114. DOI: 10.1002/Jlcr.1827  0.381
2011 Patching SG. Chemical and NMR methods for structure-function analysis of membrane proteins and their ligands. European Drug Initiative on Channels and Transporters (EDICT) General Assembly, Madrid, Spain 0.452
2011 Ma P, Nishiguchi K, Yuille HM, Patching SG, Edara S, Davis LM, Henderson PJF, Nakayama J, Phillips-Jones MK. In vitro activation and inhibition of the intact quorum membrane sensor FsrC involved in biofilms and virulence in Enterococcus faecalis V583 6th International Conference On Gram-Positive Microorganisms 0.323
2010 Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I. Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ) J Antimicrob Chemother. 65: 2566-2573. PMID 20861142 DOI: 10.1093/jac/dkq349  0.265
2010 Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I. Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). The Journal of Antimicrobial Chemotherapy. 65: 2566-73. PMID 20861142 DOI: 10.1093/Jac/Dkq349  0.757
2010 Weyand S, Ma P, Saidijam M, Baldwin J, Beckstein O, Jackson S, Suzuki S, Patching SG, Shimamura T, Sansom MSP, Iwata S, Cameron AD, Baldwin SA, Henderson PJF. The Nucleobase‐Cation‐Symport‐1 family of membrane transport proteins Handbook of Metalloproteins 0.826
2009 Patching SG, Edwards R, Middleton DA. Structural analysis of uniformly 13C-labelled solids from selective angle measurements at rotational resonance J Magn Reson. 199: 242-246. PMID 19487142 DOI: 10.1016/j.jmr.2009.05.002  0.281
2009 Patching SG, Edwards R, Middleton DA. Structural analysis of uniformly (13)C-labelled solids from selective angle measurements at rotational resonance. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 199: 242-6. PMID 19487142 DOI: 10.1016/J.Jmr.2009.05.002  0.383
2009 Henderson PJF, Suzuki S, Ma P, Saidijam M, Bettaney KE, Szakonyi G, Rutherford NG, Patching SG, Hope RJ, Roach PCJ, Shimamura T, Yajima S, Carpenter EP, Weyand S, Cameron AD, et al. Structural genomics of bacterial membrane transport proteins Acta Crystallographica Section a Foundations of Crystallography. 65: s28-s28. DOI: 10.1107/S0108767309099516  0.796
2009 Patching SG. Synthesis of highly pure 14C-labelled DL-allantoin and 13C NMR analysis of labelling integrity J Labelled Comp Radiopharm. 52: 401-404. DOI: 10.1002/Jlcr.1614  0.374
2009 Henderson PJF, Suzuki S, Ma P, Saidijam M, Bettaney K, Szakonyi G, Rutherford NG, Patching SG, Hope RJ, Roach PCJ, Shimamura T, Yajima S, Carpenter EP, Weyand S, Cameron A, et al. Structural genomics of bacterial membrane transport proteins Acta Crystallographica Section a -Foundations of Crystallography. 65: s28.  0.505
2008 Rahman M, Patching SG, Ismat F, Henderson PJ, Herbert RB, Baldwin SA, McPherson MJ. Probing metal ion substrate-binding to the E. coli ZitB exporter in native membranes by solid state NMR Mol Membr Biol. 25: 683-690. PMID 19039702 DOI: 10.1080/09687680802495267  0.421
2008 Rahman M, Patching SG, Ismat F, Henderson PJ, Herbert RB, Baldwin SA, McPherson MJ. Probing metal ion substrate-binding to the E. coli ZitB exporter in native membranes by solid state NMR. Molecular Membrane Biology. 25: 683-90. PMID 19039702 DOI: 10.1080/09687680802495267  0.798
2008 Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, et al. Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (New York, N.Y.). 322: 709-13. PMID 18927357 DOI: 10.1126/Science.1164440  0.809
2008 Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, et al. Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter Science. 322: 709-713. PMID 18927357 DOI: 10.1107/S0108767309099486  0.813
2008 Patching SG, Psakis G, Baldwin SA, Baldwin J, Henderson PJ, Middleton DA. Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR Mol Membr Biol. 25: 474-484. PMID 18798051 DOI: 10.1080/09687680802371963  0.456
2008 Patching SG, Psakis G, Baldwin SA, Baldwin J, Henderson PJF, Middleton DA. Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR Molecular Membrane Biology. 25: 474-484. PMID 18798051 DOI: 10.1080/09687680802371963  0.805
2008 Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW. 2-Aminotetralones: novel inhibitors of MurA and MurZ Bioorg Med Chem Lett. 18: 1730-1734. PMID 18261901 DOI: 10.1016/j.bmcl.2008.01.089  0.288
2008 Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW. 2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorganic & Medicinal Chemistry Letters. 18: 1730-4. PMID 18261901 DOI: 10.1016/J.Bmcl.2008.01.089  0.6
2008 Patching SG, Henderson PJ, Herbert RB, Middleton DA. Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate J Am Chem Soc. 130: 1236-1244. PMID 18177040 DOI: 10.1021/ja075584k  0.424
2008 Patching SG, Henderson PJ, Herbert RB, Middleton DA. Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate. Journal of the American Chemical Society. 130: 1236-44. PMID 18177040 DOI: 10.1021/Ja075584K  0.675
2008 Åberg G, Aigbirhio FI, Alexakis E, Al-Maharik N, Almi M, Ambacher Y, Andersson S, Athlan A, Badman G, Baldwin SA, Baumann M, Baxendale IR, Botting NP, Bragg RA, Brown JA, ... ... Patching SG, et al. 16th International Isotope Society (UK group) Symposium Journal of Labelled Compounds and Radiopharmaceuticals. 51: 247-261. DOI: 10.1002/Jlcr.1513  0.288
2008 Roach PCJ, O'Reilly J, Norbertczak HT, Hope RJ, Venter H, Patching SG, Jamshad M, Peter G. Stockley PG, Baldwin SA, Herbert RB, Rutherford NG, Bill RM, Henderson PJF. Equipping a research scale fermentation laboratory for production of membrane proteins In: McNeil B, Harvey LM, eds. Practical fermentation technology. Chichester, UK: John Wiley & Sons, Ltd . 37-67.  0.328
2008 Middleton DA, Baldwin SA, Herbert RB, Henderson PJF, Patching SG. Exploiting isotope labelling for solid-state NMR studies of drugs and their targets J Labelled Comp Radiopharm. 51: 249.  0.243
2008 Patching SG, Henderson PJF. The production of membrane proteins for NMR studies. Collaborative Computational Project for NMR (CCPN) – 8th Conference, Newton Rigg, Penrith 0.369
2006 Clough J, Saidijam M, Bettaney KE, Szakonyi G, Patching SG, Mueller J, Shibayama K, Bacon M, Barksby E, Groves M, Herbert RB, Phillips-Jones M, Ward A, Gunn-Moore F, O'Reilly J, et al. Prokaryotic membrane transport proteins: amplified expression and purification In Lundstrom KH, ed. Structural genomics on membrane proteins. Taylor and Francis . 21-42.  0.48
2006 Hadden DA, Loewen S, Ingram JC, Patching SG, Yamashita M, Conroy MJ, Middleton DA, Litherland GJ, Herbert RB, Gallagher MP, Bullough PA, Henderson PJF, Cass CE, Young D, Baldwin SA. Using the bacterial protein NupC as a model for human nucleoside drug transporters. The 4th ISGO International Conference on Structural Genomics 0.382
2005 Saidijam M, Bettaney KE, Szakonyi G, Psakis G, Shibayama K, Suzuki S, Clough JL, Blessie V, Abu-Bakr A, Baumberg S, Meuller J, Hoyle CK, Palmer SL, Butaye P, Walravens K, ... Patching SG, et al. Active membrane transport and receptor proteins from bacteria Biochem Soc Trans. 33: 867-872. PMID 16042616 DOI: 10.1042/BST0330867  0.528
2005 Saidijam M, Bettaney KE, Szakonyi G, Psakis G, Shibayama K, Suzuki S, Clough JL, Blessie V, Abu-Bakr A, Baumberg S, Meuller J, Hoyle CK, Palmer SL, Butaye P, Walravens K, ... Patching SG, et al. Active membrane transport and receptor proteins from bacteria. Biochemical Society Transactions. 33: 867-72. PMID 16042616 DOI: 10.1042/Bst0330867  0.813
2005 Patching SG, Baldwin SA, Baldwin AD, Young JD, Gallagher MP, Henderson PJ, Herbert RB. The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands Org Biomol Chem. 3: 462-470. PMID 15678184 DOI: 10.1039/b414739a  0.483
2005 Patching SG, Baldwin SA, Baldwin AD, Young JD, Gallagher MP, Henderson PJF, Herbert RB. The nucleoside transport proteins, NupC and NupG, from Escherichia coli: Specific structural motifs necessary for the binding of ligands Organic and Biomolecular Chemistry. 3: 462-470. PMID 15678184 DOI: 10.1039/B414739A  0.557
2004 Xie H, Patching SG, Gallagher MP, Litherland GJ, Brough AR, Venter H, Yao SY, Ng AM, Young JD, Herbert RB, Henderson PJ, Baldwin SA. Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family Mol Membr Biol. 21: 323-336. PMID 15513740 DOI: 10.1080/09687860400003941  0.521
2004 Xie H, Patching SG, Gallagher MP, Litherland GJ, Brough AR, Venter H, Yao SY, Ng AM, Young JD, Herbert RB, Henderson PJ, Baldwin SA. Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family. Molecular Membrane Biology. 21: 323-36. PMID 15513740 DOI: 10.1080/09687860400003941  0.729
2004 Patching SG, Brough AR, Herbert RB, Rajakarier JA, Henderson PJ, Middleton DA. Substrate affinities for membrane transport proteins determined by 13C cross-polarization magic-angle spinning nuclear magnetic resonance spectroscopy J Am Chem Soc. 126: 3072-3080. PMID 15012136 DOI: 10.1021/ja037163i  0.488
2004 Patching SG, Brough AR, Herbert RB, Rajakarier JA, Henderson PJ, Middleton DA. Substrate affinities for membrane transport proteins determined by 13C cross-polarization magic-angle spinning nuclear magnetic resonance spectroscopy. Journal of the American Chemical Society. 126: 3072-80. PMID 15012136 DOI: 10.1021/Ja037163I  0.71
2004 Patching SG, Herbert RB, O'Reilly J, Brough AR, Henderson PJ. Low 13C-background for NMR-based studies of ligand binding using 13C-depleted glucose as carbon source for microbial growth: 13C-labeled glucose and 13C-forskolin binding to the galactose-H+ symport protein GalP in Escherichia coli J Am Chem Soc. 126: 86-87. PMID 14709072 DOI: 10.1021/ja038275c  0.426
2004 Patching SG, Herbert RB, O'Reilly J, Brough AR, Henderson PJ. Low 13C-background for NMR-based studies of ligand binding using 13C-depleted glucose as carbon source for microbial growth: 13C-labeled glucose and 13C-forskolin binding to the galactose-H+ symport protein GalP in Escherichia coli. Journal of the American Chemical Society. 126: 86-7. PMID 14709072 DOI: 10.1021/Ja038275C  0.676
2004 Caddick S, Stone-Elander S, Patching SG, Herbert RB, Henderson PJF, Brough AR, Middleton DA, Coumbarides GS, Eames J, Ghilagaber S, Suggate MJ, Weerasooriya N, Spivey AC, Diaper C, Srikaran R, et al. 13th IIS(UK group) symposium Journal of Labelled Compounds and Radiopharmaceuticals. 47: 299-334. DOI: 10.1002/Jlcr.819  0.425
2004 Patching SG, Herbert RB, Henderson PJF, Brough AR, Middleton DA. Stable isotopes and membrane transport proteins: chemical synthesis and biochemical analysis by solid state NMR J Labelled Comp Radiopharm. 47: 303.  0.497
2003 Patching SG, Middleton DA, Henderson PJ, Herbert RB. The economical synthesis of [2'-(13)C, 1,3-(15)N2]uridine; preliminary conformational studies by solid state NMR. Organic & Biomolecular Chemistry. 1: 2057-62. PMID 12945895 DOI: 10.1039/B301275A  0.617
2003 Patching SG, Middleton DA, Henderson PJ, Herbert RB. The economical synthesis of [2'-13C, 1,3-15N2]uridine; preliminary conformational studies by solid state NMR Org Biomol Chem. 1: 2057-2062. DOI: 10.1039/B301275A  0.561
2002 Patching SG. Chemical and solid-state NMR approaches to determine structure-activity relationships for substrates bound to the nucleoside transport proteins, NupC and NupG, of Escherichia coli Phd Thesis 0.463
2000 Patching S, Henderson P, Spooner P, Watts A, Baldwin S, Gallagher M, Litherland G, Herbert R. A Solid State NMR Approach to the Structure-Activity Relationship of the Nucleoside Transport Protein NupC of Escherichia coli Biochemical Society Transactions. 28: A89-A89. DOI: 10.1042/Bst028A089C  0.739
2000 Patching SG, Henderson PJF, Spooner PJR, Watts A, Baldwin SA, Herbert RB. A solid-state NMR approach to the structure-activity relationship of the nucleoside transport protein NupC of Escherichia coli Biochem Soc Trans. 28: A89.  0.455
2000 Patching SG, Brough AR, Henderson PJF, Baldwin SA, Spooner PJR, Watts A, Gallagher MP, Litherland GJ, Herbert RB. The direct observation by solid state NMR of nucleosides specifically bound to the Escherichia coli membrane transport protein NupC International Workshop “the Future of Solid State Nmr in Biology” 0.529
1999 Patching SG, Gardiner PH. Recent developments in selenium metabolism and chemical speciation: a review J Trace Elem Med Biol. 13: 193-214. PMID 10707342 DOI: 10.1016/s0946-672x(99)80037-6  0.286
1999 Patching SG, Gardiner PH. Recent developments in selenium metabolism and chemical speciation: a review. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 13: 193-214. PMID 10707342 DOI: 10.1016/S0946-672X(99)80037-6  0.387
1998 Patching SG. The successful “Design and synthesis of a novel water-soluble functionalised blue dye for protein visualisation in electrophoresis Research Project Thesis 0.302
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