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Naoaki Fujii - Publications

Affiliations: 
2003-2005 Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Actis M, Fujii N, Mackey ZB. A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM-binding pocket of proliferating cell nuclear antigen orthologs. Chemical Biology & Drug Design. PMID 37767622 DOI: 10.1111/cbdd.14361  0.34
2018 Vanarotti M, Grace CR, Miller DJ, Actis ML, Inoue A, Evison BJ, Vaithiyalingam S, Singh AP, McDonald ET, Fujii N. Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction. Journal of Molecular Biology. PMID 29864443 DOI: 10.1016/j.jmb.2018.05.042  0.353
2018 Vanarotti M, Evison BJ, Actis ML, Inoue A, McDonald ET, Shao Y, Heath RJ, Fujii N. Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance. Bioorganic & Medicinal Chemistry. PMID 29598900 DOI: 10.1016/j.bmc.2018.03.028  0.308
2015 Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, et al. RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 5272-9. PMID 25825779 DOI: 10.1073/Pnas.1504161112  0.324
2014 Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. The Journal of Biological Chemistry. 289: 7109-20. PMID 24474685 DOI: 10.1074/Jbc.M113.520429  0.365
2012 Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. The Journal of Biological Chemistry. 287: 14289-300. PMID 22383522 DOI: 10.1074/Jbc.M112.353201  0.429
2009 Mahindroo N, Connelly MC, Punchihewa C, Kimura H, Smeltzer MP, Wu S, Fujii N. Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription. Journal of Medicinal Chemistry. 52: 4277-87. PMID 19545120 DOI: 10.1021/Jm900106F  0.326
2009 Punchihewa C, Ferreira AM, Cassell R, Rodrigues P, Fujii N. Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Science : a Publication of the Protein Society. 18: 994-1002. PMID 19388021 DOI: 10.1002/pro.109  0.347
2009 Mahindroo N, Punchihewa C, Fujii N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. Journal of Medicinal Chemistry. 52: 3829-45. PMID 19309080 DOI: 10.1021/Jm801420Y  0.398
2008 You L, Xu Z, Punchihewa C, Jablons DM, Fujii N. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Molecular Cancer Therapeutics. 7: 1633-8. PMID 18566234 DOI: 10.1158/1535-7163.Mct-08-0155  0.345
2008 Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Partial acetylation of lysine residues improves intraprotein cross-linking. Analytical Chemistry. 80: 951-60. PMID 18201069 DOI: 10.1021/Ac701636W  0.5
2008 Mahindroo N, Punchihewa C, Bail AM, Fujii N. Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorganic & Medicinal Chemistry Letters. 18: 946-9. PMID 18180158 DOI: 10.1016/j.bmcl.2007.12.039  0.33
2008 Mayasundari A, Ferreira AM, He L, Mahindroo N, Bashford D, Fujii N. Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains. Bioorganic & Medicinal Chemistry Letters. 18: 942-5. PMID 18180157 DOI: 10.1016/j.bmcl.2007.12.038  0.368
2007 Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Research. 67: 573-9. PMID 17234765 DOI: 10.1158/0008-5472.Can-06-2726  0.525
2007 Fujii N, Shelat A, Hall RA, Guy RK. Design of a selective chemical probe for class I PDZ domains. Bioorganic & Medicinal Chemistry Letters. 17: 546-8. PMID 17074480 DOI: 10.1016/J.Bmcl.2006.10.027  0.528
2007 Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorganic & Medicinal Chemistry Letters. 17: 549-52. PMID 17055267 DOI: 10.1016/J.Bmcl.2006.10.006  0.552
2005 Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorganic & Medicinal Chemistry Letters. 15: 121-3. PMID 15582423 DOI: 10.1016/J.Bmcl.2004.10.023  0.474
2004 Fujii N, Jacobsen RB, Wood NL, Schoeniger JS, Guy RK. A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D). Bioorganic & Medicinal Chemistry Letters. 14: 427-9. PMID 14698174 DOI: 10.1016/J.Bmcl.2003.10.043  0.484
2003 Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. A selective irreversible inhibitor targeting a PDZ protein interaction domain. Journal of the American Chemical Society. 125: 12074-5. PMID 14518976 DOI: 10.1021/Ja035540L  0.587
2003 Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 42: 2797-805. PMID 12627945 DOI: 10.1021/Bi027061P  0.557
2002 Novak KA, Fujii N, Guy RK. Investigation of the PDZ domain ligand binding site using chemically modified peptides. Bioorganic & Medicinal Chemistry Letters. 12: 2471-4. PMID 12161160 DOI: 10.1016/S0960-894X(02)00345-1  0.522
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