| Year |
Citation |
Score |
| 2024 |
Cuevas EP, Martinez-Gonzalez L, Gordillo C, Tosat-Bitrián C, Pérez de la Lastra C, Sáenz A, Gil C, Palomo V, Martin-Requero Á, Martinez A. Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis. Neurobiology of Disease. 192: 106430. PMID 38325718 DOI: 10.1016/j.nbd.2024.106430 |
0.347 |
|
| 2023 |
Martinez-Gonzalez L, Cuevas EP, Tosat-Bitrián C, Nozal V, Gil C, Palomo V, Martín-Requero Á, Martinez A. TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer's disease patients. Frontiers in Molecular Neuroscience. 16: 1243277. PMID 37621404 DOI: 10.3389/fnmol.2023.1243277 |
0.387 |
|
| 2023 |
Rodríguez-Periñán G, de la Encarnación A, Moreno F, López de Munain A, Martínez A, Martín-Requero Á, Alquézar C, Bartolomé F. Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions. Antioxidants (Basel, Switzerland). 12. PMID 36978829 DOI: 10.3390/antiox12030581 |
0.698 |
|
| 2023 |
Porras G, Ruiz S, Maestro I, Borrego-Hernández D, Redondo AG, Martínez A, Martín-Requero Á. Functional Characterization of a Familial ALS-Associated Missense (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts. International Journal of Molecular Sciences. 24. PMID 36769169 DOI: 10.3390/ijms24032847 |
0.311 |
|
| 2022 |
Cuevas EP, Rodríguez-Fernández A, Palomo V, Martínez A, Martín-Requero Á. TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer's Disease Patients. Biomedicines. 10. PMID 35203594 DOI: 10.3390/biomedicines10020385 |
0.408 |
|
| 2020 |
Vaca G, Martinez-Gonzalez L, Fernandez A, Rojas-Prats E, Porras G, Cuevas EP, Gil C, Martinez A, Martin-Requero Á. Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). Journal of Neurochemistry. PMID 32628315 DOI: 10.1111/Jnc.15118 |
0.309 |
|
| 2020 |
Nuñez-Borque E, González-Naranjo P, Bartolomé F, Alquézar C, Reinares-Sebastián A, Pérez C, Ceballos ML, Páez JA, Campillo NE, Martín-Requero Á. Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations. Molecular Neurobiology. PMID 31898159 DOI: 10.1007/s12035-019-01813-4 |
0.713 |
|
| 2019 |
Cosín-Tomàs M, Senserrich J, Arumí-Planas M, Alquézar C, Pallàs M, Martín-Requero Á, Suñol C, Kaliman P, Sanfeliu C. Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients. Nutrients. 11. PMID 31370365 DOI: 10.3390/nu11081764 |
0.704 |
|
| 2018 |
Del Cerro P, Alquézar C, Bartolomé F, González-Naranjo P, Pérez C, Carro E, Páez JA, Campillo NE, Martín-Requero Á. Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease. Cns Drugs. PMID 29736745 DOI: 10.1007/s40263-018-0515-7 |
0.713 |
|
| 2017 |
Wojsiat J, Laskowska-Kaszub K, Alquézar C, Białopiotrowicz E, Esteras N, Zdioruk M, Martin-Requero A, Wojda U. Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants. Molecular Neurobiology. 54: 5683-5698. PMID 27644130 DOI: 10.1007/s12035-016-0105-y |
0.721 |
|
| 2016 |
Alquezar C, Salado IG, de la Encarnación A, Pérez DI, Moreno F, Gil C, de Munain AL, Martínez A, Martín-Requero Á. Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia. Molecular Neurodegeneration. 11: 36. PMID 27138926 DOI: 10.1186/S13024-016-0102-7 |
0.727 |
|
| 2016 |
de la Encarnación A, Alquézar C, Martín-Requero Á. Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration. Molecular Neurobiology. 53: 7107-7118. PMID 26676574 DOI: 10.1007/s12035-015-9596-1 |
0.728 |
|
| 2016 |
Alquézar C, de la Encarnación A, Moreno F, López de Munain A, Martín-Requero Á. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. Journal of Psychiatry & Neuroscience : Jpn. 41: 225-39. PMID 26624524 DOI: 10.1503/jpn.150131 |
0.736 |
|
| 2016 |
Esteras N, Alquézar C, de la Encarnación A, Martín-Requero Á. Lymphocytes in Alzheimer's disease pathology: Altered signaling pathways. Current Alzheimer Research. 13: 439-49. PMID 26567747 DOI: 10.2174/1567205013666151116124912 |
0.737 |
|
| 2015 |
Wojsiat J, Prandelli C, Laskowska-Kaszub K, Martín-Requero A, Wojda U. Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects. Journal of Alzheimer's Disease : Jad. 46: 329-50. PMID 25737047 DOI: 10.3233/JAD-141977 |
0.405 |
|
| 2015 |
Alquézar C, Barrio E, Esteras N, de la Encarnación A, Bartolomé F, Molina JA, Martín-Requero Á. Targeting cyclin D3/CDK6 activity for treatment of Parkinson's disease. Journal of Neurochemistry. 133: 886-97. PMID 25689470 DOI: 10.1111/jnc.13070 |
0.714 |
|
| 2015 |
Alquezar C, Esteras N, de la Encarnación A, Moreno F, López de Munain A, Martín-Requero Á. Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 25: 386-403. PMID 25624003 DOI: 10.1016/j.euroneuro.2014.12.007 |
0.768 |
|
| 2015 |
de la Encarnación A, Alquézar C, Esteras N, Martín-Requero Á. Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells. Molecular Neurobiology. 52: 1714-1725. PMID 25377796 DOI: 10.1007/s12035-014-8965-5 |
0.742 |
|
| 2015 |
Esteras N, Alquézar C, Bartolomé F, de la Encarnación A, Bermejo-Pareja F, Molina JA, Martín-Requero Á. G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients. Molecular Neurobiology. 52: 386-98. PMID 25182869 DOI: 10.1007/s12035-014-8870-y |
0.717 |
|
| 2014 |
Alquézar C, Esteras N, de la Encarnación A, Alzualde A, Moreno F, López de Munain A, Martín-Requero A. PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers. Neurobiology of Aging. 35: 886-98. PMID 24139281 DOI: 10.1016/j.neurobiolaging.2013.09.021 |
0.749 |
|
| 2013 |
Esteras N, Alquézar C, de la Encarnación A, Villarejo A, Bermejo-Pareja F, Martín-Requero A. Calmodulin levels in blood cells as a potential biomarker of Alzheimer's disease. Alzheimer's Research & Therapy. 5: 55. PMID 24499616 DOI: 10.1186/alzrt219 |
0.733 |
|
| 2013 |
Esteras N, Alquézar C, Bermejo-Pareja F, Bialopiotrowicz E, Wojda U, Martín-Requero A. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. Neurobiology of Aging. 34: 1090-100. PMID 23153928 DOI: 10.1016/j.neurobiolaging.2012.10.014 |
0.765 |
|
| 2012 |
Esteras N, Bartolomé F, Alquézar C, Antequera D, Muñoz Ú, Carro E, Martín-Requero Á. Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)]. The European Journal of Neuroscience. 36: 2609-18. PMID 22702220 DOI: 10.1111/j.1460-9568.2012.08178.x |
0.764 |
|
| 2012 |
Alquezar C, Esteras N, Alzualde A, Moreno F, Ayuso MS, López de Munain A, Martín-Requero Á. Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A. Plos One. 7: e37057. PMID 22623979 DOI: 10.1371/journal.pone.0037057 |
0.72 |
|
| 2012 |
Esteras N, Alquézar C, Bartolomé F, Antequera D, Barrios L, Carro E, Cerdán S, Martín-Requero A. Systematic evaluation of magnetic resonance imaging and spectroscopy techniques for imaging a transgenic model of Alzheimer's disease (AβPP/PS1). Journal of Alzheimer's Disease : Jad. 30: 337-53. PMID 22406445 DOI: 10.3233/Jad-2012-111967 |
0.662 |
|
| 2012 |
Esteras N, Muñoz Ú, Alquézar C, Bartolomé F, Bermejo-Pareja F, Martín-Requero Á. Altered calmodulin degradation and signaling in non-neuronal cells from Alzheimer's disease patients. Current Alzheimer Research. 9: 267-77. PMID 22044025 DOI: 10.2174/156720512800107564 |
0.756 |
|
| 2012 |
Alquezar C, Esteras N, Bartolomé F, Merino JJ, Alzualde A, López de Munain A, Martín-Requero Á. Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia. Neurobiology of Aging. 33: 429.e7-20. PMID 21232819 DOI: 10.1016/j.neurobiolaging.2010.11.020 |
0.75 |
|
| 2010 |
Bartolomé F, Muñoz U, Esteras N, Alquezar C, Collado A, Bermejo-Pareja F, Martín-Requero A. Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer's disease patients. Cellular and Molecular Life Sciences : Cmls. 67: 4257-68. PMID 20614159 DOI: 10.1007/s00018-010-0443-2 |
0.771 |
|
| 2009 |
Bartolomé F, Muñoz U, Esteras N, Esteban J, Bermejo-Pareja F, Martín-Requero A. Distinct regulation of cell cycle and survival in lymphocytes from patients with Alzheimer's disease and amyotrophic lateral sclerosis. International Journal of Clinical and Experimental Pathology. 2: 390-8. PMID 19158936 |
0.452 |
|
| 2008 |
Sala SG, Muñoz U, Bartolomé F, Bermejo F, Martín-Requero A. HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. The Journal of Pharmacology and Experimental Therapeutics. 324: 352-9. PMID 17928568 DOI: 10.1124/jpet.107.128959 |
0.48 |
|
| 2008 |
Muñoz U, Bartolomé F, Bermejo F, Martín-Requero A. Enhanced proteasome-dependent degradation of the CDK inhibitor p27(kip1) in immortalized lymphocytes from Alzheimer's dementia patients. Neurobiology of Aging. 29: 1474-84. PMID 17448572 DOI: 10.1016/j.neurobiolaging.2007.03.013 |
0.451 |
|
| 2005 |
Muñoz U, de Las Cuevas N, Bartolomé F, Hermida OG, Bermejo F, Martín-Requero A. The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. Experimental Neurology. 195: 508-17. PMID 16061222 DOI: 10.1016/j.expneurol.2005.06.010 |
0.477 |
|
| 2005 |
de las Cuevas N, Muñoz U, Hermida OG, Martín-Requero A. Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients. Neurobiology of Aging. 26: 615-24. PMID 15708436 DOI: 10.1016/j.neurobiolaging.2004.06.006 |
0.471 |
|
| 2003 |
de las Cuevas N, Urcelay E, Hermida OG, Saíz-Diaz RA, Bermejo F, Ayuso MS, Martín-Requero A. Ca2+/calmodulin-dependent modulation of cell cycle elements pRb and p27kip1 involved in the enhanced proliferation of lymphoblasts from patients with Alzheimer dementia. Neurobiology of Disease. 13: 254-63. PMID 12901840 DOI: 10.1016/s0969-9961(03)00040-8 |
0.499 |
|
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