Kevin Michael O'Shaughnessy, MB, BS, DPhil - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
 Medicine University of Cambridge, Cambridge, England, United Kingdom 
Area:
Hypertension, WNK pathway, Renal Physiology, Pre-eclampsia, medical genetics, arterial stiffness, Aldosterone, Conn's Syndrome
Website:
http://emit.medschl.cam.ac.uk/people/investigators/dr-kevin-oshaughnessy/

43/101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel Khalek W, Argaiz E, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, et al. Mutations affecting the conserved acidic WNK1 motif cause inherited hyperkalemic hyperchloremic acidosis. The Journal of Clinical Investigation. PMID 32790646 DOI: 10.1172/Jci94171  0.439
2019 Murthy M, O'Shaughnessy KM. Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K. Physiological Reports. 7: e14280. PMID 31762176 DOI: 10.14814/phy2.14280  0.518
2019 Sandilands AJ, O'Shaughnessy KM, Yasmin Y. 1-adrenoceptor polymorphisms and blood pressure: 49S variant increases plasma renin but not blood pressure in hypertensive patients. American Journal of Hypertension. PMID 30753253 DOI: 10.1093/Ajh/Hpz019  0.744
2018 Maskari RA, Hardege I, Cleary S, Figg N, Li Y, Siew K, Khir A, Yu Y, Liu P, Wilkinson I, O'Shaughnessy K, Yasmin. Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness. European Journal of Human Genetics : Ejhg. 26: 1648-1657. PMID 30089823 DOI: 10.1038/s41431-018-0226-z  0.677
2018 Yasmin, Maskari RA, McEniery CM, Cleary SE, Li Y, Siew K, Figg NL, Khir AW, Cockcroft JR, Wilkinson IB, O'Shaughnessy KM. The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness. Scientific Reports. 8: 8550. PMID 29867203 DOI: 10.1038/s41598-018-25851-5  0.709
2017 Hardege I, Long L, Al Maskari R, Figg N, O'Shaughnessy KM. Targeted disruption of the KCNJ5 gene in the female mouse lowers aldosterone levels. Clinical Science (London, England : 1979). PMID 29222092 DOI: 10.1042/Cs20171285  0.775
2017 Ware JS, Wain LV, Channavajjhala SK, Jackson VE, Edwards E, Lu R, Siew K, Jia W, Shrine N, Kinnear S, Jalland M, Henry AP, Clayton J, O'Shaughnessy KM, Tobin MD, et al. Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. The Journal of Clinical Investigation. 127: 3367-3374. PMID 28783044 DOI: 10.1172/JCI89812  0.734
2016 Murthy M, Kurz T, O'Shaughnessy KM. WNK signalling pathways in blood pressure regulation. Cellular and Molecular Life Sciences : Cmls. PMID 27815594 DOI: 10.1007/s00018-016-2402-z  0.581
2016 Al Maskari R, Yasmin, Cleary S, Figg N, Mehta S, Rassl D, Wilkinson I, O'Shaughnessy KM. A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression. European Journal of Human Genetics : Ejhg. PMID 27782106 DOI: 10.1038/Ejhg.2016.143  0.733
2016 Murthy M, Kurz T, O'Shaughnessy KM. ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation. Physiological Reports. 4. PMID 27378813 DOI: 10.14814/Phy2.12850  0.649
2015 Hardege I, Xu S, Gordon RD, Thompson AJ, Figg N, Stowasser M, Murrell-Lagnado R, O'Shaughnessy KM. Novel insertion mutation in KCNJ5 channel produces constitutive aldosterone release from H295R cells. Molecular Endocrinology (Baltimore, Md.). me20151195. PMID 26340408 DOI: 10.1210/Me.2015-1195  0.738
2015 Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. Embo Molecular Medicine. 7: 1285-306. PMID 26286618 DOI: 10.15252/emmm.201505444  0.754
2015 Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Human Molecular Genetics. 24: 4545-58. PMID 25994507 DOI: 10.1093/hmg/ddv185  0.745
2015 Barber J, McKeever TM, McDowell SE, Clayton JA, Ferner RE, Gordon RD, Stowasser M, O'Shaughnessy KM, Hall IP, Glover M. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? British Journal of Clinical Pharmacology. 79: 566-77. PMID 25139696 DOI: 10.1111/Bcp.12499  0.521
2014 O'Shaughnessy KM. Gordon Syndrome: a continuing story. Pediatric Nephrology (Berlin, Germany). PMID 25503323 DOI: 10.1007/s00467-014-2956-7  0.3
2014 Murthy M, Xu S, Massimo G, Wolley M, Gordon RD, Stowasser M, O'Shaughnessy KM. Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism. Hypertension. 63: 783-9. PMID 24420545 DOI: 10.1161/Hypertensionaha.113.02234  0.626
2014 Glover M, Ware JS, Henry A, Wolley M, Walsh R, Wain LV, Xu S, Van't Hoff WG, Tobin MD, Hall IP, Cook S, Gordon RD, Stowasser M, O'Shaughnessy KM. Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome). Clinical Science (London, England : 1979). 126: 721-6. PMID 24266877 DOI: 10.1042/Cs20130326  0.586
2014 Siew K, de los Heros P, Alessi DR, O'Shaughnessy KM. Erratum: PD.1. Blood pressure maintenance in MO25β has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse Journal of Human Hypertension. 28: 342-342. DOI: 10.1038/Jhh.2013.120  0.64
2014 Maskari RA, Cleary S, Li Y, Khir A, Mitchell G, Wilkinson I, O'Shaughnessy K, Yasmin. Genetic variations on chromosome 14 influence BCL11B gene expression levels and aortic stiffness Artery Research. 8: 126-127. DOI: 10.1016/J.Artres.2014.09.070  0.718
2014 Yasmin, McEniery C, Cleary S, Lam B, Kuper H, Endo Y, Kinra S, Chen D, Chandak G, Deanfield J, Lawlor D, Cockcroft J, Wilkinson I, O'Shaughnessy K. Genome wide association scan identifies loci for arterial stiffness in young healthy adults Artery Research. 8: 122. DOI: 10.1016/J.Artres.2014.09.050  0.693
2013 Glover M, O'Shaughnessy KM. Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia. Clinical and Experimental Pharmacology & Physiology. 40: 876-84. PMID 23683032 DOI: 10.1111/1440-1681.12115  0.631
2013 Siew K, O'Shaughnessy KM. Extrarenal roles of the with-no-lysine[K] kinases (WNKs). Clinical and Experimental Pharmacology & Physiology. 40: 885-94. PMID 23662678 DOI: 10.1111/1440-1681.12108  0.69
2012 Murthy M, Azizan EA, Brown MJ, O'Shaughnessy KM. Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. Journal of Hypertension. 30: 1827-33. PMID 22743686 DOI: 10.1097/HJH.0b013e328356139f  0.56
2012 Azizan EA, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, Brown MJ, O'Shaughnessy KM. Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas. Hypertension. 59: 587-91. PMID 22252394 DOI: 10.1161/Hypertensionaha.111.186239  0.587
2012 Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O'Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, et al. Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Circulation. Cardiovascular Genetics. 5: 81-90. PMID 22068335 DOI: 10.1161/Circgenetics.111.959817  0.365
2012 Gordon R, Stowasser M, Xu S, Wolley M, Glover M, O'Shaughnessy K. Relevance of plasma aldosterone responsiveness to upright posture, hybrid steroids and histology of Aldosterone-Producing Adenomas (APAs) to the finding of KCNJ5 mutations in some APAs American Journal of Hypertension. 25: 1315-1315. DOI: 10.1038/Ajh.2012.134  0.554
2011 Glover M, Zuber AM, O'Shaughnessy KM. Hypertension, dietary salt intake, and the role of the thiazide-sensitive sodium chloride transporter NCCT. Cardiovascular Therapeutics. 29: 68-76. PMID 21167012 DOI: 10.1111/J.1755-5922.2010.00180.X  0.574
2011 Glover M, O'shaughnessy KM. SPAK and WNK kinases: a new target for blood pressure treatment? Current Opinion in Nephrology and Hypertension. 20: 16-22. PMID 21088576 DOI: 10.1097/Mnh.0B013E32834132Bc  0.597
2010 Glover M, Sweeny C, Davis B, O'Shaughnessy KM. A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190. The Open Medicinal Chemistry Journal. 4: 57-61. PMID 21249167 DOI: 10.2174/1874104501004010057  0.544
2010 Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM. The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. Canadian Journal of Physiology and Pharmacology. 88: 986-95. PMID 20962898 DOI: 10.1139/y10-080  0.569
2010 Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. Embo Molecular Medicine. 2: 63-75. PMID 20091762 DOI: 10.1002/Emmm.200900058  0.68
2009 Glover M, Zuber AM, O'Shaughnessy KM. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. Journal of the American Society of Nephrology : Jasn. 20: 1314-22. PMID 19470686 DOI: 10.1681/Asn.2008050542  0.577
2008 Murthy M, Cope G, O'Shaughnessy KM. The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK. Biochemical and Biophysical Research Communications. 375: 651-4. PMID 18755144 DOI: 10.1016/j.bbrc.2008.08.076  0.513
2007 Burton TJ, O'Shaughnessy KM, Brown MJ. The epithelial Na+ channel as a determinant of blood pressure Current Hypertension Reviews. 3: 45-49. DOI: 10.2174/157340207779815491  0.444
2006 Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM. Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. American Journal of Physiology. Renal Physiology. 291: F1369-76. PMID 16788137 DOI: 10.1152/ajprenal.00468.2005  0.567
2006 Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM. WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. Journal of the American Society of Nephrology : Jasn. 17: 1867-74. PMID 16775035 DOI: 10.1681/ASN.2005111224  0.576
2006 Yasmin, O'Shaughnessy KM, McEniery CM, Cockcroft JR, Wilkinson IB. Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals. Journal of Hypertension. 24: 499-502. PMID 16467653 DOI: 10.1097/01.Hjh.0000209986.74477.18  0.402
2005 Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 46: 295-300. PMID 15998707 DOI: 10.1161/01.HYP.0000174326.96918.d6  0.557
2005 Cope G, Golbang A, O'Shaughnessy KM. WNK kinases and the control of blood pressure. Pharmacology & Therapeutics. 106: 221-31. PMID 15866321 DOI: 10.1016/J.Pharmthera.2004.11.010  0.405
2003 Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, Ye L, Thompson P, Shou Y, O'Shaughnessy K, Ronco P, Brown J. PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1966-8. PMID 12923071 DOI: 10.1096/Fj.03-0181Fje  0.354
2001 O'Shaughnessy KM, Fu B, Downing S, Morris NH. Thrombophilic polymorphisms in pre-eclampsia: altered frequency of the functional 98C>T polymorphism of glycoprotein IIIa. Journal of Medical Genetics. 38: 775-7. PMID 11732486 DOI: 10.1136/Jmg.38.11.775  0.36
2001 O'Shaughnessy KM. The genetics of essential hypertension. British Journal of Clinical Pharmacology. 51: 5-11. PMID 11167660 DOI: 10.1046/J.1365-2125.2001.01254.X  0.364
1998 O'Shaughnessy KM, Fu B, Johnson A, Gordon RD. Linkage of Gordon's syndrome to the long arm of chromosome 17 in a region recently linked to familial essential hypertension. Journal of Human Hypertension. 12: 675-8. PMID 9819014 DOI: 10.1038/Sj.Jhh.1000705  0.312
Low-probability matches (unlikely to be authored by this person)
2009 Burton TJ, Cope G, Wang J, Sim JC, Azizan EAB, O'Shaughnessy KM, Brown MJ. Corrigendum to: "Expression of the epithelial Na+ channel and other components of an aldosterone response pathway in human adrenocortical cells" [European Journal of Pharmacology 613 (2009) 176-181] (DOI:10.1016/j.ejphar.2009.04.005) European Journal of Pharmacology. 617: 131. DOI: 10.1016/J.Ejphar.2009.06.034  0.295
2003 Sandilands AJ, O'Shaughnessy KM, Brown MJ. Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta 1-adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium. British Journal of Pharmacology. 138: 386-92. PMID 12540530 DOI: 10.1038/Sj.Bjp.0705030  0.291
2005 Sandilands AJ, O'Shaughnessy KM. The functional significance of genetic variation within the beta-adrenoceptor. British Journal of Clinical Pharmacology. 60: 235-43. PMID 16120061 DOI: 10.1111/J.1365-2125.2005.02438.X  0.282
2004 Hiby SE, Walker JJ, O'shaughnessy KM, Redman CW, Carrington M, Trowsdale J, Moffett A. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. The Journal of Experimental Medicine. 200: 957-65. PMID 15477349 DOI: 10.1084/Jem.20041214  0.28
2004 Sandilands A, Yeo G, Brown MJ, O'Shaughnessy KM. Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms. Pharmacogenetics. 14: 343-9. PMID 15247626 DOI: 10.1097/00008571-200406000-00003  0.278
2011 Mercier-Zuber A, O'Shaughnessy KM. Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. Current Opinion in Nephrology and Hypertension. 20: 534-40. PMID 21610494 DOI: 10.1097/MNH.0b013e3283484b06  0.276
2013 Chowdhury JA, Liu CH, Zuber AM, O'Shaughnessy KM. An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II). Clinical Science (London, England : 1979). 124: 701-8. PMID 23336180 DOI: 10.1042/CS20120430  0.273
2000 O'shaughnessy KM, Fu B, Dickerson C, Thurston D, Brown MJ. The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects Clinical Science. 99: 233-238. DOI: 10.1042/Cs0990233  0.269
2009 O'Shaughnessy KM. Dissecting complex traits: recent advances in hypertension genomics. Genome Medicine. 1: 43. PMID 19439027 DOI: 10.1186/gm43  0.242
2008 Yasmin, O'Shaughnessy KM. Genetics of arterial structure and function: towards new biomarkers for aortic stiffness? Clinical Science (London, England : 1979). 114: 661-77. PMID 18442360 DOI: 10.1042/CS20070369  0.242
1997 Hingorani A, Liang C, Fatibene J, Parsons A, Hopper R, Trutwein D, Stephens N, O'Shaughnessy K, Brown M. A Variant of the Endothelial Nitric Oxide Synthase Gene is a Risk Factor for Coronary Atherosclerosis Clinical Science. 93: 18P-18P. DOI: 10.1042/Cs093018Pa  0.24
2006 Yasmin, McEniery CM, O'Shaughnessy KM, Harnett P, Arshad A, Wallace S, Maki-Petaja K, McDonnell B, Ashby MJ, Brown J, Cockcroft JR, Wilkinson IB. Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1799-805. PMID 16709939 DOI: 10.1161/01.ATV.0000227717.46157.32  0.238
2023 O'Shaughnessy KM. Genetic Markers Regulating Blood Pressure in Extreme Discordant Sib Pairs. Genes. 14. PMID 37895212 DOI: 10.3390/genes14101862  0.236
1983 Heal DJ, O'Shaughnessy KM, Smith SL, Nutt DJ. Hypophysectomy alters both 5-hydroxytryptamine- and alpha 2-adrenoceptor-mediated behavioural changes in the rat. European Journal of Pharmacology. 89: 167-71. PMID 6305683 DOI: 10.1016/0014-2999(83)90624-6  0.235
2000 Sharma P, Fatibene J, Ferraro F, Jia H, Monteith S, Brown C, Clayton D, O'Shaughnessy K, Brown MJ. Genome-wide search for susceptibility loci to human essential hypertension Hypertension. 35: 1291-1296. PMID 10856279 DOI: 10.1161/01.Hyp.35.6.1291  0.228
2001 Farzaneh-Far A, Davies JD, Braam LA, Spronk HM, Proudfoot D, Chan SW, O'Shaughnessy KM, Weissberg PL, Vermeer C, Shanahan CM. A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. The Journal of Biological Chemistry. 276: 32466-73. PMID 11425864 DOI: 10.1074/Jbc.M104909200  0.227
2001 Foo R, O'Shaughnessy KM, Brown MJ. Hyperaldosteronism: recent concepts, diagnosis, and management. Postgraduate Medical Journal. 77: 639-44. PMID 11571370 DOI: 10.1136/Pmj.77.912.639  0.224
1999 Lewis I, Lachmeijer G, Downing S, Dekker G, Glazebrook C, Clayton D, Morris NH, O'Shaughnessy KM. Failure to detect linkage of preeclampsia to the region of the NOS3 locus on chromosome 7q. American Journal of Human Genetics. 64: 310-3. PMID 9915975 DOI: 10.1086/302179  0.216
2011 Carss KJ, Stowasser M, Gordon RD, O'Shaughnessy KM. Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II. Journal of Human Hypertension. 25: 560-4. PMID 20927129 DOI: 10.1038/jhh.2010.93  0.213
2001 Hu CT, O'Shaughnessy KM. Glycerol-enhanced mini-polyacrylamide gel electrophoresis for the separation of differentially expressed DNA fragments in cDNA representational difference analysis. Electrophoresis. 22: 1063-8. PMID 11358126 DOI: 10.1002/1522-2683()22:6<1063::Aid-Elps1063>3.0.Co;2-S  0.205
2000 O'Shaughnessy KM, Fu B, Dickerson C, Thurston D, Brown MJ. The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects. Clinical Science (London, England : 1979). 99: 233-8. PMID 11787477  0.202
2006 O'Shaughnessy KM, Karet FE. Salt handling and hypertension. Annual Review of Nutrition. 26: 343-65. PMID 16602929 DOI: 10.1146/annurev.nutr.26.061505.111316  0.198
2004 O'Shaughnessy KM, Karet FE. Salt handling and hypertension. The Journal of Clinical Investigation. 113: 1075-81. PMID 15085183 DOI: 10.1172/JCI21560  0.194
2009 Burton TJ, Cope G, Wang J, Sim JC, Azizan EA, O'Shaughnessy KM, Brown MJ. Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells. European Journal of Pharmacology. 613: 176-81. PMID 19371736 DOI: 10.1016/J.Ejphar.2009.04.005  0.188
2006 Yasmin, Wilkinson IB, O'Shaughnessy KM. Influence of fibrillin-1 genotype on aortic stiffness in men: a note of caution. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1431; author reply 1. PMID 16540720 DOI: 10.1152/japplphysiol.01408.2005  0.179
2006 O'Shaughnessy KM. Role of diet in hypertension management. Current Hypertension Reports. 8: 292-7. PMID 16884659  0.176
2010 Cheriyan J, O'Shaughnessy KM, Brown MJ. Primary prevention of CVD: treating hypertension. Bmj Clinical Evidence. 2010. PMID 21733198  0.172
1999 O'Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, Morris NH. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension. 33: 1338-41. PMID 10373212  0.161
2006 O'Shaughnessy KM. HapMap, pharmacogenomics, and the goal of personalized prescribing. British Journal of Clinical Pharmacology. 61: 783-6. PMID 16722846 DOI: 10.1111/j.1365-2125.2006.02683.x  0.15
1999 Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A, Haydock S, Hopper RV, Stephens NG, O'Shaughnessy KM, Brown MJ. A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK. Circulation. 100: 1515-20. PMID 10510054 DOI: 10.1161/01.Cir.100.14.1515  0.147
2008 Brenner T, O'Shaughnessy KM. Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion. American Journal of Physiology. Endocrinology and Metabolism. 295: E1480-6. PMID 18854423 DOI: 10.1152/ajpendo.90652.2008  0.143
2005 Sandilands AJ, Parameshwar J, Large S, Brown MJ, O'Shaughnessy KM. Confirmation of a role for the 389R>G beta-1 adrenoceptor polymorphism on exercise capacity in heart failure. Heart (British Cardiac Society). 91: 1613-4. PMID 16287753 DOI: 10.1136/Hrt.2004.047282  0.143
1997 Sharma P, Pathan S, Fatibene J, Jia H, Thompson D, Monteith S, Clayton D, O'Shaughnessy K, Brown MJ. Annual Scientific Meeting of the British Hypertension Society. Wills Hall, University of Bristol, 15-17 September 1997. Genome wide search for susceptibility loci in essential hypertension: Early results Journal of Hypertension. 15: 1529.  0.142
1998 Liyou N, Simons L, Friedlander Y, Simons J, McCallum J, O'Shaughnessy K, Davis D, Johnson A. Coronary artery disease is not associated with the E298→D variant of the constitutive, endothelial nitric oxide synthase gene [2] Clinical Genetics. 54: 528-529. PMID 9894802  0.112
2021 Kulkarni S, Rao R, Goodman JDH, Connolly K, O'Shaughnessy KM. Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study. Medicine. 100: e24654. PMID 33832064 DOI: 10.1097/MD.0000000000024654  0.103
2000 O'shaughnessy KM, Ferraro F, Fu B, Downing S, Morris NH. Identification of monozygotic twins that are concordant for preeclampsia. American Journal of Obstetrics and Gynecology. 182: 1156-7. PMID 10819852 DOI: 10.1067/mob.2000.105429  0.098
1992 O'Shaughnessy KM, Newman CM, Warren JB. Inhibition in the rat of nitric oxide synthesis in vivo does not attenuate the hypotensive action of acetylcholine, ATP or bradykinin. Experimental Physiology. 77: 285-92. PMID 1581056  0.094
2007 Broughton Pipkin F, Kalsheker N, Morgan L, O'Malley S, Henfrey M, Arulkumaran S, Symonds I, Cameron A, Dominiczak A, McDade M, Kwong Lee W, McCulloch J, Caulfield M, Farrall M, Kilby M, et al. Babies, pre-eclamptic mothers and grandparents: A three-generation phenotyping study Journal of Hypertension. 25: 849-854. PMID 17351378 DOI: 10.1097/Hjh.0B013E32803Fb634  0.092
1994 Hirokawa K, O'Shaughnessy KM, Ramrakha P, Wilkins MR. Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids. British Journal of Pharmacology. 113: 1448-54. PMID 7534188  0.088
1992 Kobayashi H, Adachi M, Satoh H, Nishikata H, Imai T, O'Shaughnessy KM, Fuller RW, Takahashi T. Mechanisms of PAF-induced airway hyperresponsiveness in the dog: The effect of ketotifen and the role of thromboxane A2 Immunology and Allergy Practice. 14: 433-443.  0.084
1991 Taylor IK, Ward PS, O'Shaughnessy KM, Dollery CT, Black P, Barrow SE, Taylor GW, Fuller RW. Thromboxane A2 biosynthesis in acute asthma and after antigen challenge. The American Review of Respiratory Disease. 143: 119-25. PMID 1986668 DOI: 10.1164/ajrccm/143.1.119  0.077
2016 Kennard L, O'Shaughnessy KM. Treating hypertension in patients with medical comorbidities. Bmj (Clinical Research Ed.). 352: i101. PMID 26884124 DOI: 10.1136/bmj.i101  0.075
1986 Heal DJ, Philpot J, O'Shaughnessy KM, Davies CL. The influence of central noradrenergic function on 5-HT2-mediated head-twitch responses in mice: possible implications for the actions of antidepressant drugs. Psychopharmacology. 89: 414-20. PMID 3018823 DOI: 10.1007/BF02412113  0.074
1983 O'Shaughnessy K, Hladky SB. Transient currents carried by the uncoupler, carbonyl cyanide m-chlorophenylhydrazone Bba - Bioenergetics. 724: 381-387. PMID 6615824 DOI: 10.1016/0005-2728(83)90097-X  0.067
1994 Sala A, Folco G, O'Shaughnessy KM. Differential effects of fluticasone propionate on allergen-evoked bronchoconstriction and increased urinary leukotriene E4 excretion [1] American Journal of Respiratory and Critical Care Medicine. 150: 287. PMID 8025766  0.051
1993 O'Shaughnessy KM, Wellings R, Gillies B, Fuller RW. Differential effects of fluticasone propionate on allergen-evoked bronchoconstriction and increased urinary leukotriene E4 excretion. The American Review of Respiratory Disease. 147: 1472-6. PMID 8389108 DOI: 10.1164/ajrccm/147.6_Pt_1.1472  0.051
1992 Taylor IK, O'Shaughnessy KM, Choudry NB, Adachi M, Palmer JB, Fuller RW. A comparative study in atopic subjects with asthma of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity, and increase in urinary leukotriene E4 excretion. The Journal of Allergy and Clinical Immunology. 89: 575-83. PMID 1346794 DOI: 10.1016/0091-6749(92)90325-V  0.049
1991 O'Shaughnessy KM, Taylor IK, Fuller RW. β2-agonists in asthma (VII) Lancet. 337: 45-46.  0.034
1993 O'Shaughnessy KM, Taylor IK, O'Connor B, O'Connell F, Thomson H, Dollery CT. Potent leukotriene D4 receptor antagonist ICI 204,219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction. The American Review of Respiratory Disease. 147: 1431-5. PMID 8389105 DOI: 10.1164/ajrccm/147.6_Pt_1.1431  0.031
1991 Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet (London, England). 337: 690-4. PMID 1672176 DOI: 10.1016/0140-6736(91)90277-V  0.028
1996 Taylor IK, Hill AA, Hayes M, Rhodes CG, O'Shaughnessy KM, O'Connor BJ, Jones HA, Hughes JM, Jones T, Pride NB, Fuller RW. Imaging allergen-invoked airway inflammation in atopic asthma with [18F]-fluorodeoxyglucose and positron emission tomography. Lancet (London, England). 347: 937-40. PMID 8598758 DOI: 10.1016/S0140-6736(96)91416-6  0.024
2016 O'Shaughnessy KM, Kennard L. Authors' reply to Ninan and Millar and Abou-saleh. Bmj (Clinical Research Ed.). 353: i2253. PMID 27118732  0.023
2016 O'Shaughnessy KM, Kennard L. Authors' reply to Ninan and Millar and Abou-saleh Bmj (Online). 353. DOI: 10.1136/bmj.i2253  0.023
1997 Taylor IK, Rhodes CG, O'Shaughnessy KM, Liistro G. Noninvasive imaging of airway inflammation in asthma Monaldi Archives For Chest Disease. 52: 197.  0.017
2018 O'Shaughnessy K. SUPPORTIVE CARE NEEDS OF PROSTATE CANCER SURVIVORS. Australian Nursing & Midwifery Journal. 24: 34. PMID 29251471  0.017
2000 Ramkissoon Y, Ghoorahoo H, Haydock SF, O'Shaughnessy KM. An unusual complication of carcinoma of the caecum. Postgraduate Medical Journal. 76: 438, 451-2. PMID 10878219  0.013
2011 Baulis H, Montagu A, Davies E, Wake M, O'Shaughnessy K, Deuter K, Gillham D, McCutcheon H. The use of audio-visual communication strategies in the emergency waiting room to improve patient and staff satisfaction Australasian Emergency Nursing Journal. 14: S28-S29. DOI: 10.1016/j.aenj.2011.09.072  0.01
2006 O'Shaughnessy K. Pharmacogenomics, Methods and Protocols British Journal of Clinical Pharmacology. 62: 253-253. DOI: 10.1111/j.1365-2125.2006.02624.x  0.01
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