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Alejandro Villarino - Publications

Affiliations: 
University of Miami Medical School, Miami, FL, United States 
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Schultz AB, Kugler DG, Nivelo L, Vitari N, Doyle LP, Ristin S, Hennighausen L, O'Shea JJ, Jankovic D, Villarino AV. T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis. Frontiers in Immunology. 14: 1212190. PMID 37559725 DOI: 10.3389/fimmu.2023.1212190  0.69
2023 Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, et al. Transcription factor EGR2 controls homing and pathogenicity of T17 cells in the central nervous system. Nature Immunology. PMID 37443284 DOI: 10.1038/s41590-023-01553-7  0.402
2023 Villarino AV. Transcriptional programing of T cell metabolism by STAT family transcription factors. European Journal of Immunology. e2048825. PMID 37009861 DOI: 10.1002/eji.202048825  0.326
2023 Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, ... ... Villarino AV, et al. Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer. Cancer Discovery. PMID 36946782 DOI: 10.1158/2159-8290.CD-22-1046  0.341
2022 Villarino AV, Laurence AD, Davis FP, Nivelo L, Brooks SR, Sun HW, Jiang K, Afzali B, Frasca D, Hennighausen L, Kanno Y, O'Shea JJ. A central role for STAT5 in the transcriptional programing of T helper cell metabolism. Science Immunology. 7: eabl9467. PMID 36427325 DOI: 10.1126/sciimmunol.abl9467  0.359
2021 Cannons JL, Villarino AV, Kapnick SM, Preite S, Shih HY, Gomez-Rodriguez J, Kaul Z, Shibata H, Reilley JM, Huang B, Handon R, McBain IT, Gossa S, Wu T, Su HC, et al. PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8 T cells at the expense of central memory. Cell Reports. 37: 109804. PMID 34644563 DOI: 10.1016/j.celrep.2021.109804  0.475
2021 Valença-Pereira F, Fang Q, Marié IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M. IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca through the noncanonical STAT3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34507993 DOI: 10.1073/pnas.2103444118  0.598
2020 Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Reports. 33: 108498. PMID 33326784 DOI: 10.1016/j.celrep.2020.108498  0.603
2020 Sciumè G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Yao C, Signorella S, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara K, Zitti B, et al. Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells. Immunity. PMID 33010223 DOI: 10.1016/j.immuni.2020.09.008  0.307
2020 Carpio VH, Aussenac F, Puebla-Clark L, Wilson KD, Villarino AV, Dent AL, Stephens R. T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria. Iscience. 23: 101310. PMID 32634740 DOI: 10.1016/J.Isci.2020.101310  0.559
2020 Bauché D, Joyce-Shaikh B, Fong J, Villarino AV, Ku KS, Jain R, Lee YC, Annamalai L, Yearley JH, Cua DJ. IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis. Science Immunology. 5. PMID 32332067 DOI: 10.1126/sciimmunol.aav1080  0.623
2019 Papillion A, Powell MD, Chisolm DA, Bachus H, Fuller MJ, Weinmann AS, Villarino A, O'Shea JJ, León B, Oestreich KJ, Ballesteros-Tato A. Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T cells. Science Immunology. 4. PMID 31519812 DOI: 10.1126/Sciimmunol.Aaw7636  0.704
2019 Petermann F, Pękowska A, Johnson CA, Jankovic D, Shih HY, Jiang K, Hudson WH, Brooks SR, Sun HW, Villarino AV, Yao C, Singleton K, Akondy RS, Kanno Y, Sher A, et al. The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1. Molecular Cell. PMID 31377117 DOI: 10.1016/J.Molcel.2019.06.025  0.303
2018 Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, et al. STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells. Journal of Immunology (Baltimore, Md. : 1950). 200: 110-118. PMID 29187589 DOI: 10.4049/jimmunol.1701133  0.491
2017 Le Saout C, Luckey MA, Villarino AV, Smith M, Hasley RB, Myers TG, Imamichi H, Park JH, O'Shea JJ, Lane HC, Catalfamo M. IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion. Jci Insight. 2. PMID 29202461 DOI: 10.1172/jci.insight.96228  0.661
2017 Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 47: 435-449.e8. PMID 28930659 DOI: 10.1016/J.Immuni.2017.08.012  0.703
2017 Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ. Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells. The Journal of Experimental Medicine. PMID 28916644 DOI: 10.1084/jem.20150907  0.436
2016 Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Science Immunology. 1. PMID 28713870 DOI: 10.1126/Sciimmunol.Aaf8612  0.62
2016 Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ. Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions. Elife. 5. PMID 26999798 DOI: 10.7554/Elife.08384  0.306
2015 Villarino AV, O'Shea JJ, Hunter CA. IL-27 shakes up the establishment of ectopic lymphoid structures. The Journal of Experimental Medicine. 212: 1757. PMID 26482142 DOI: 10.1084/jem.21211insight4  0.658
2015 Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, et al. Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity. Immunity. 42: 877-89. PMID 25992861 DOI: 10.1016/J.Immuni.2015.04.014  0.705
2015 Villarino AV, Laurence A. IL-1 watches the watchmen. Nature Immunology. 16: 226-7. PMID 25689436 DOI: 10.1038/ni.3105  0.574
2014 Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nature Genetics. 46: 1140-6. PMID 25217959 DOI: 10.1038/ng.3089  0.525
2014 Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunological Reviews. 261: 23-49. PMID 25123275 DOI: 10.1111/Imr.12208  0.392
2014 Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, et al. A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood. 123: 2978-87. PMID 24632714 DOI: 10.1182/Blood-2013-09-523167  0.311
2013 Chang CH, Curtis JD, Maggi LB, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 153: 1239-51. PMID 23746840 DOI: 10.1016/J.Cell.2013.05.016  0.38
2012 Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ. Distinct requirements for T-bet in gut innate lymphoid cells. The Journal of Experimental Medicine. 209: 2331-8. PMID 23209316 DOI: 10.1084/Jem.20122097  0.574
2012 Gallo E, Katzman S, Villarino AV. IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens. European Journal of Immunology. 42: 2322-8. PMID 22684943 DOI: 10.1002/Eji.201142227  0.646
2011 Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas AK. Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity. 34: 50-60. PMID 21236706 DOI: 10.1016/J.Immuni.2010.12.014  0.384
2010 Villarino AV, Gallo E, Abbas AK. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 185: 6461-71. PMID 20974984 DOI: 10.4049/Jimmunol.1001343  0.651
2010 Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proceedings of the National Academy of Sciences of the United States of America. 107: 18085-90. PMID 20921406 DOI: 10.1073/Pnas.1010560107  0.362
2010 Caretto D, Katzman SD, Villarino AV, Gallo E, Abbas AK. Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 184: 30-4. PMID 19949064 DOI: 10.4049/Jimmunol.0903412  0.445
2008 Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJM, Joyce S, Hunter CA. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD International Immunology. 20: 739-752. PMID 18375937 DOI: 10.1093/Intimm/Dxn032  0.744
2007 Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals Journal of Experimental Medicine. 204: 65-71. PMID 17227909 DOI: 10.1084/Jem.20061198  0.769
2006 Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. The Journal of Experimental Medicine. 203: 2785-91. PMID 17130300 DOI: 10.1084/Jem.20061341  0.673
2006 Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology. 7: 937-45. PMID 16906166 DOI: 10.1038/Ni1376  0.743
2006 Villarino AV, Stumhofer JS, Saris CJM, Kastelein RA, De Sauvage FJ, Hunter CA. IL-27 limits IL-2 production during Th1 differentiation Journal of Immunology. 176: 237-247. PMID 16365415 DOI: 10.4049/Jimmunol.176.1.237  0.789
2005 Villarino AV, Larkin J, Saris CJ, Caton AJ, Lucas S, Wong T, de Sauvage FJ, Hunter CA. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. Journal of Immunology (Baltimore, Md. : 1950). 174: 7684-91. PMID 15944269 DOI: 10.4049/Jimmunol.174.12.7684  0.714
2005 Sun J, Walsh M, Villarino AV, Cervi L, Hunter CA, Choi Y, Pearce EJ. TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. Journal of Immunology (Baltimore, Md. : 1950). 174: 742-51. PMID 15634894 DOI: 10.4049/Jimmunol.174.2.742  0.684
2005 Hunter CA, Villarino A, Artis D, Scott P. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunological Reviews. 202: 106-14. PMID 15546389 DOI: 10.1111/J.0105-2896.2004.00213.X  0.764
2004 Artis D, Villarino A, Silverman M, He W, Thornton EM, Mu S, Summer S, Covey TM, Huang E, Yoshida H, Koretzky G, Goldschmidt M, Wu GD, de Sauvage F, Miller HR, et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. Journal of Immunology (Baltimore, Md. : 1950). 173: 5626-34. PMID 15494513 DOI: 10.4049/Jimmunol.173.9.5626  0.722
2004 Villarino AV, Hunter CA. Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27 Arthritis Research and Therapy. 6: 225-233. PMID 15380038 DOI: 10.1186/Ar1227  0.701
2004 Villarino AV, Huang E, Hunter CA. Understanding the pro- and anti-inflammatory properties of IL-27 Journal of Immunology. 173: 715-720. PMID 15240655 DOI: 10.4049/Jimmunol.173.2.715  0.723
2004 Artis D, Johnson LM, Joyce K, Saris C, Villarino A, Hunter CA, Scott P. Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. Journal of Immunology (Baltimore, Md. : 1950). 172: 4672-5. PMID 15067040 DOI: 10.4049/Jimmunol.172.8.4672  0.697
2003 Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H, Kastelein RA, Saris C, Hunter CA. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 19: 645-55. PMID 14614852 DOI: 10.1016/S1074-7613(03)00300-5  0.761
2003 Tato CM, Villarino A, Caamaño JH, Boothby M, Hunter CA. Inhibition of NF-κB Activity in T and NK Cells Results in Defective Effector Cell Expansion and Production of IFN-γ Required for Resistance to Toxoplasma gondii Journal of Immunology. 170: 3139-3146. PMID 12626571 DOI: 10.4049/Jimmunol.170.6.3139  0.708
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