| Year |
Citation |
Score |
| 2023 |
Pantelejevs T, Zuazua-Villar P, Koczy O, Counsell AJ, Walsh SJ, Robertson NS, Spring DR, Downs JA, Hyvönen M. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science. 14: 13915-13923. PMID 38075664 DOI: 10.1039/d3sc03331g |
0.773 |
|
| 2023 |
Cioffi VB, de Castro-Amarante MF, Lulla A, Andreata-Santos R, Cruz MC, Moreno ACR, de Oliveira Silva M, de Miranda Peres B, de Freitas Junior LHG, Moraes CB, Durigon EL, Gordon NC, Hyvönen M, de Souza Ferreira LC, Balan A. SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies. Scientific Reports. 13: 16821. PMID 37798298 DOI: 10.1038/s41598-023-43720-8 |
0.766 |
|
| 2023 |
Yam-Puc JC, Hosseini Z, Horner EC, Gerber PP, Beristain-Covarrubias N, Hughes R, Lulla A, Rust M, Boston R, Ali M, Fischer K, Simmons-Rosello E, O'Reilly M, Robson H, Booth LH, et al. Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade. Nature Communications. 14: 3292. PMID 37369658 DOI: 10.1038/s41467-023-38810-0 |
0.47 |
|
| 2023 |
Dimitrijevs P, Makrecka-Kuka M, Bogucka A, Hyvönen M, Pantelejevs T, Arsenyan P. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. European Journal of Medicinal Chemistry. 257: 115504. PMID 37216812 DOI: 10.1016/j.ejmech.2023.115504 |
0.758 |
|
| 2023 |
Knyphausen P, Rangel Pereira M, Brear P, Hyvönen M, Jermutus L, Hollfelder F. Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature Communications. 14: 768. PMID 36765057 DOI: 10.1038/s41467-023-36099-7 |
0.56 |
|
| 2023 |
Nain-Perez A, Nilsson O, Lulla A, Håversen L, Brear P, Liljenberg S, Hyvönen M, Borén J, Grøtli M. Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. European Journal of Medicinal Chemistry. 250: 115177. PMID 36753880 DOI: 10.1016/j.ejmech.2023.115177 |
0.611 |
|
| 2022 |
Brear P, De Fusco C, Atkinson EL, Iegre J, Francis-Newton NJ, Venkitaraman AR, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action. Rsc Medicinal Chemistry. 13: 1420-1426. PMID 36426237 DOI: 10.1039/d2md00161f |
0.546 |
|
| 2022 |
Battisti UM, Gao C, Nilsson O, Akladios F, Lulla A, Bogucka A, Nain-Perez A, Håversen L, Kim W, Boren J, Hyvönen M, Uhlen M, Mardinoglu A, Grøtli M. Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase. Chembiochem : a European Journal of Chemical Biology. PMID 36250581 DOI: 10.1002/cbic.202200339 |
0.617 |
|
| 2022 |
Brear P, Hyvönen M. Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α. Acta Crystallographica. Section F, Structural Biology Communications. 78: 348-353. PMID 36189718 DOI: 10.1107/S2053230X22008767 |
0.353 |
|
| 2022 |
Neun S, Brear P, Campbell E, Tryfona T, El Omari K, Wagner A, Dupree P, Hyvönen M, Hollfelder F. Functional metagenomic screening identifies an unexpected β-glucuronidase. Nature Chemical Biology. PMID 35799064 DOI: 10.1038/s41589-022-01071-x |
0.538 |
|
| 2022 |
Karusheva Y, Ratcliff M, Mörseburg A, Barker P, Melvin A, Sattar N, Burling K, Backmark A, Roth R, Jermutus L, Guiu-Jurado E, Blüher M, Welsh P, Hyvönen M, O'Rahilly S. The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels. The Journal of Applied Laboratory Medicine. PMID 35796717 DOI: 10.1093/jalm/jfac055 |
0.756 |
|
| 2022 |
Pantelejevs T, Hyvönen M. Divergent binding mode for a protozoan BRC repeat to RAD51. The Biochemical Journal. 479: 1031-1043. PMID 35502837 DOI: 10.1042/BCJ20220141 |
0.79 |
|
| 2022 |
Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvönen M, Spring DR. Development of small cyclic peptides targeting the CK2α/β interface. Chemical Communications (Cambridge, England). 58: 4791-4794. PMID 35343996 DOI: 10.1039/d2cc00707j |
0.517 |
|
| 2022 |
Nain-Perez A, Foller Füchtbauer A, Håversen L, Lulla A, Gao C, Matic J, Monjas L, Rodríguez A, Brear P, Kim W, Hyvönen M, Borén J, Mardinoglu A, Uhlen M, Grøtli M. Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. European Journal of Medicinal Chemistry. 234: 114270. PMID 35290845 DOI: 10.1016/j.ejmech.2022.114270 |
0.667 |
|
| 2022 |
Synakewicz M, Eapen RS, Perez-Riba A, Rowling PJE, Bauer D, Weißl A, Fischer G, Hyvönen M, Rief M, Itzhaki LS, Stigler J. Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix. Acs Nano. 16: 3895-3905. PMID 35258937 DOI: 10.1021/acsnano.1c09162 |
0.372 |
|
| 2022 |
Talbot-Cooper C, Pantelejevs T, Shannon JP, Cherry CR, Au MT, Hyvönen M, Hickman HD, Smith GL. Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Cell Host & Microbe. PMID 35182467 DOI: 10.1016/j.chom.2022.01.014 |
0.779 |
|
| 2021 |
Lindenburg LH, Pantelejevs T, Gielen F, Zuazua-Villar P, Butz M, Rees E, Kaminski CF, Downs JA, Hyvönen M, Hollfelder F. Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34772801 DOI: 10.1073/pnas.2017708118 |
0.779 |
|
| 2021 |
Ratcliff M, Zhou RX, Jermutus L, Hyvönen M. The role of pro-domains in human growth factors and cytokines. Biochemical Society Transactions. PMID 34495310 DOI: 10.1042/BST20200663 |
0.75 |
|
| 2021 |
Iegre J, Atkinson EL, Brear PD, Cooper BM, Hyvönen M, Spring DR. Chemical probes targeting the kinase CK2: a journey outside the catalytic box. Organic & Biomolecular Chemistry. 19: 4380-4396. PMID 34037044 DOI: 10.1039/d1ob00257k |
0.556 |
|
| 2021 |
Atkinson EL, Iegre J, Brear PD, Zhabina EA, Hyvönen M, Spring DR. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules (Basel, Switzerland). 26. PMID 33807474 DOI: 10.3390/molecules26071977 |
0.542 |
|
| 2021 |
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology. PMID 33662256 DOI: 10.1016/j.chembiol.2021.02.006 |
0.524 |
|
| 2020 |
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, et al. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical Science. 11: 10792-10801. PMID 34094333 DOI: 10.1039/d0sc01232g |
0.754 |
|
| 2020 |
Brear P, Ball D, Stott K, D'Arcy S, Hyvönen M. Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α. Journal of Medicinal Chemistry. 63: 12786-12798. PMID 33119282 DOI: 10.1021/acs.jmedchem.0c01173 |
0.4 |
|
| 2020 |
Strizhak AV, Babii O, Afonin S, Bakanovich I, Pantelejevs T, Xu W, Fowler E, Eapen R, Sharma K, Platonov MO, Hurmach VV, Itzhaki L, Hyvönen M, Ulrich AS, Spring DR, et al. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Organic & Biomolecular Chemistry. PMID 32390036 DOI: 10.1039/d0ob00831a |
0.794 |
|
| 2019 |
Sharma P, Mahen R, Rossmann M, Stokes JE, Hardwick B, Huggins DJ, Emery A, Kunciw DL, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Scientific Reports. 9: 15930. PMID 31685831 DOI: 10.1038/S41598-019-50702-2 |
0.529 |
|
| 2019 |
Sharma K, Strizhak AV, Fowler E, Wang X, Xu W, Hatt Jensen C, Wu Y, Sore HF, Lau YH, Hyvönen M, Itzhaki LS, Spring DR. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. Organic & Biomolecular Chemistry. PMID 31418442 DOI: 10.1039/c9ob01745c |
0.673 |
|
| 2019 |
Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical Science. 10: 5056-5063. PMID 31183056 DOI: 10.1039/c9sc00798a |
0.549 |
|
| 2019 |
Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 633-634. PMID 30778404 DOI: 10.1039/c8sc90248h |
0.459 |
|
| 2019 |
Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 694-700. PMID 30774870 DOI: 10.1039/c8sc04645j |
0.469 |
|
| 2018 |
van Loo B, Bayer CD, Fischer G, Jonas S, Valkov E, Mohamed MF, Vorobieva A, Dutruel C, Hyvonen M, Hollfelder F. Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily. Journal of the American Chemical Society. PMID 30497259 DOI: 10.1021/Jacs.8B10290 |
0.546 |
|
| 2018 |
Miton CM, Jonas S, Fischer G, Duarte F, Mohamed MF, van Loo B, Kintses B, Kamerlin SCL, Tokuriki N, Hyvönen M, Hollfelder F. Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proceedings of the National Academy of Sciences of the United States of America. PMID 30012610 DOI: 10.1073/Pnas.1607817115 |
0.546 |
|
| 2018 |
Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Novel non-ATP competitive small molecules targeting the CK2 α/β interface. Bioorganic & Medicinal Chemistry. PMID 29759799 DOI: 10.1016/j.bmc.2018.05.011 |
0.529 |
|
| 2018 |
Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Second-generation CK2α inhibitors targeting the αD pocket. Chemical Science. 9: 3041-3049. PMID 29732088 DOI: 10.1039/c7sc05122k |
0.527 |
|
| 2018 |
van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvönen M, Hollfelder F. Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester. Journal of Molecular Biology. PMID 29458126 DOI: 10.1016/J.Jmb.2018.02.010 |
0.512 |
|
| 2018 |
Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB. Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29348202 DOI: 10.1073/Pnas.1714622115 |
0.774 |
|
| 2018 |
Cotton TR, Fischer G, Wang X, McCoy JC, Czepnik M, Thompson TB, Hyvönen M. Structure of the human myostatin precursor and determinants of growth factor latency. The Embo Journal. PMID 29330193 DOI: 10.15252/Embj.201797883 |
0.784 |
|
| 2017 |
Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chemical Communications (Cambridge, England). PMID 28787041 DOI: 10.1039/C7Cc05379G |
0.514 |
|
| 2017 |
Xu ER, Blythe EE, Fischer G, Hyvönen M. Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2. The Journal of Biological Chemistry. PMID 28584056 DOI: 10.1074/jbc.M117.788992 |
0.791 |
|
| 2017 |
De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorganic & Medicinal Chemistry. PMID 28495381 DOI: 10.1016/j.bmc.2017.04.037 |
0.531 |
|
| 2017 |
Rossmann M, J Greive S, Moschetti T, Dinan M, Hyvönen M. Development of a multipurpose scaffold for the display of peptide loops. Protein Engineering, Design & Selection : Peds. 30: 419-430. PMID 28444399 DOI: 10.1093/protein/gzx017 |
0.326 |
|
| 2017 |
Pereira MR, Maester TC, Mercaldi GF, de Macedo Lemos EG, Hyvönen M, Balan A. From a metagenomic source to a high-resolution structure of a novel alkaline esterase. Applied Microbiology and Biotechnology. PMID 28331945 DOI: 10.1007/s00253-017-8226-4 |
0.788 |
|
| 2017 |
Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvönen M, Edel JB, Kaminski CF, Hollfelder F. Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets. Analytical Chemistry. 89: 1092-1101. PMID 28192993 DOI: 10.1021/Acs.Analchem.6B02528 |
0.551 |
|
| 2017 |
Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvonen M, Verma CS, Spring DR, Itzhaki LS. Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase. Journal of the American Chemical Society. PMID 28084734 DOI: 10.1021/jacs.6b10234 |
0.549 |
|
| 2016 |
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Specific inhibition of CK2α from an anchor outside the active site. Chemical Science. 7: 6839-6845. PMID 28451126 DOI: 10.1039/C6Sc02335E |
0.643 |
|
| 2016 |
Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng H, Morgan M, Scott D, Blundell TL, Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51. Journal of Molecular Biology. PMID 27725183 DOI: 10.1016/J.Jmb.2016.10.009 |
0.628 |
|
| 2016 |
Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M. ATP half-sites in RadA and RAD51 recombinases bind nucleotides. Febs Open Bio. 6: 372-85. PMID 27419043 DOI: 10.1002/2211-5463.12052 |
0.588 |
|
| 2016 |
Wang X, Fischer G, Hyvönen M. Structure and activation of pro-activin A. Nature Communications. 7: 12052. PMID 27373274 DOI: 10.1038/ncomms12052 |
0.665 |
|
| 2016 |
Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Scientific Reports. 6: 28528. PMID 27339427 DOI: 10.1038/Srep28528 |
0.58 |
|
| 2016 |
Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE, Thomas CJ. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proceedings of the National Academy of Sciences of the United States of America. PMID 27325754 DOI: 10.1073/Pnas.1600630113 |
0.518 |
|
| 2016 |
Kišonaitė M, Wang X, Hyvönen M. Structure of Gremlin-1 and analysis of its interaction with BMP-2. The Biochemical Journal. 473: 1593-604. PMID 27036124 DOI: 10.1042/BCJ20160254 |
0.776 |
|
| 2016 |
Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51:BRCA2 Protein-Protein Interaction. Febs Letters. PMID 26992456 DOI: 10.1002/1873-3468.12139 |
0.607 |
|
| 2015 |
Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angewandte Chemie (International Ed. in English). 54: 15410-3. PMID 26768531 DOI: 10.1002/Anie.201508416 |
0.546 |
|
| 2015 |
Colin PY, Kintses B, Gielen F, Miton CM, Fischer G, Mohamed MF, Hyvönen M, Morgavi DP, Janssen DB, Hollfelder F. Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics. Nature Communications. 6: 10008. PMID 26639611 DOI: 10.1038/Ncomms10008 |
0.521 |
|
| 2015 |
Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. Chemmedchem. 10: 296-303. PMID 25470112 DOI: 10.1002/Cmdc.201402428 |
0.643 |
|
| 2013 |
Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem : a European Journal of Chemical Biology. 14: 332-42. PMID 23344974 DOI: 10.1002/Cbic.201200521 |
0.626 |
|
| 2011 |
?led? P, Stubbs CJ, Lang S, Yang YQ, McKenzie GJ, Venkitaraman AR, Hyvönen M, Abell C. From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 50: 4003-6. PMID 21472932 DOI: 10.1002/Anie.201008019 |
0.509 |
|
| 2010 |
van Loo B, Jonas S, Babtie AC, Benjdia A, Berteau O, Hyvönen M, Hollfelder F. An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 107: 2740-5. PMID 20133613 DOI: 10.1073/Pnas.0903951107 |
0.524 |
|
| 2009 |
Hagemann AI, Xu X, Nentwich O, Hyvonen M, Smith JC. Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus. Development (Cambridge, England). 136: 2803-13. PMID 19605501 DOI: 10.1242/Dev.034124 |
0.339 |
|
| 2008 |
Jonas S, van Loo B, Hyvönen M, Hollfelder F. A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum. Journal of Molecular Biology. 384: 120-36. PMID 18793651 DOI: 10.1016/J.Jmb.2008.08.072 |
0.547 |
|
| 2003 |
Innis CA, Hyvönen M. Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. The Journal of Biological Chemistry. 278: 39969-77. PMID 12867435 DOI: 10.1074/jbc.M211284200 |
0.35 |
|
| Show low-probability matches. |