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Lynn Wecker, Ph.D. - Publications

Affiliations: 
Psychiatry and Behavioral Neurosciences University of South Florida, Tampa, FL, United States 
Area:
Pharmacology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Johns BE, Ficken M, Engberg ME, Wecker L, Philpot RM. Increasing dietary choline attenuates spatial memory deficits resulting from exposure to the chemotherapeutic agents cyclophosphamide and doxorubicin. Journal of Psychopharmacology (Oxford, England). 2698811211029752. PMID 34225528 DOI: 10.1177/02698811211029752  0.484
2019 Philpot RM, Ficken M, Johns BE, Engberg ME, Wecker L. Spatial memory deficits in mice induced by chemotherapeutic agents are prevented by acetylcholinesterase inhibitors. Cancer Chemotherapy and Pharmacology. PMID 31302713 DOI: 10.1007/S00280-019-03881-8  0.522
2017 Wecker L, Marrero-Rosado B, Engberg ME, Johns BE, Philpot RM. 3-Acetylpyridine neurotoxicity in mice. Neurotoxicology. 58: 143-152. PMID 27986589 DOI: 10.1016/J.Neuro.2016.11.010  0.563
2016 Philpot RM, Ficken M, Wecker L. Doxorubicin and cyclophosphamide lead to long-lasting impairment of spatial memory in female, but not male mice. Behavioural Brain Research. 307: 165-175. PMID 27083301 DOI: 10.1016/J.Bbr.2016.04.017  0.53
2016 Schroeder RA, Wecker L, Philpot RM. Obstacles and opportunities for cholinergic drug development in the treatment of cognitive disorders. Current Pharmaceutical Design. PMID 26818870 DOI: 10.2174/1381612822666160127111453  0.508
2016 Young MF, Wecker L. Regulation of Gait and Balance: The Underappreciated Role of Neuronal Nicotinic Receptor Agonists. Current Pharmaceutical Design. PMID 26818868 DOI: 10.2174/1381612822666160127111848  0.384
2016 Schroeder RA, Wecker L, Philpot RM. Obstacles and opportunities for cholinergic drug development in the treatment of cognitive disorders Current Pharmaceutical Design. 22: 1981-1985. DOI: 10.2174/1381612822666160127111453  0.461
2015 Lambert CS, Philpot RM, Engberg ME, Johns BE, Wecker L. Analysis of gait in rats with olivocerebellar lesions and ability of the nicotinic acetylcholine receptor agonist varenicline to attenuate impairments. Behavioural Brain Research. 291: 342-50. PMID 26049061 DOI: 10.1016/J.Bbr.2015.05.056  0.574
2015 Lambert CS, Philpot RM, Engberg ME, Johns BE, Wecker L. Analysis of gait in rats with olivocerebellar lesions and ability of the nicotinic acetylcholine receptor agonist varenicline to attenuate impairments Behavioural Brain Research. 291: 342-350. DOI: 10.1016/j.bbr.2015.05.056  0.552
2014 Lambert CS, Philpot RM, Engberg ME, Johns BE, Kim SH, Wecker L. Gait analysis and the cumulative gait index (CGI): Translational tools to assess impairments exhibited by rats with olivocerebellar ataxia. Behavioural Brain Research. 274: 334-43. PMID 25116252 DOI: 10.1016/J.Bbr.2014.08.004  0.549
2014 Fernandez JW, Grizzell JA, Philpot RM, Wecker L. Postpartum depression in rats: differences in swim test immobility, sucrose preference and nurturing behaviors. Behavioural Brain Research. 272: 75-82. PMID 24983658 DOI: 10.1016/J.Bbr.2014.06.041  0.662
2014 Philpot RM, Engberg ME, Wecker L. Ethanol conditioned place preference and alterations in ΔFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment. Behavioural Brain Research. 262: 101-8. PMID 24412683 DOI: 10.1016/J.Bbr.2013.12.014  0.601
2013 Wecker L, Engberg ME, Philpot RM, Lambert CS, Kang CW, Antilla JC, Bickford PC, Hudson CE, Zesiewicz TA, Rowell PP. Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia. Neuropharmacology. 73: 75-86. PMID 23711550 DOI: 10.1016/J.Neuropharm.2013.05.016  0.597
2013 Fernandez JW, Grizzell JA, Wecker L. The role of estrogen receptor β and nicotinic cholinergic receptors in postpartum depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40: 199-206. PMID 23063492 DOI: 10.1016/J.Pnpbp.2012.10.002  0.598
2013 Lambert C, Philpot R, Engberg M, Wecker L. Varenicline ameliorates spatial and temporal gait deficits following 3-acetylpyridine-induced ataxia in rats Biochemical Pharmacology. 86: 1234. DOI: 10.1016/J.Bcp.2013.08.054  0.545
2012 Zesiewicz TA, Greenstein PE, Sullivan KL, Wecker L, Miller A, Jahan I, Chen R, Perlman SL. A randomized trial of varenicline (Chantix) for the treatment of spinocerebellar ataxia type 3. Neurology. 78: 545-50. PMID 22323747 DOI: 10.1212/Wnl.0B013E318247Cc7A  0.304
2012 Philpot RM, Engberg ME, Wecker L. Effects of nicotine exposure on locomotor activity and pCREB levels in the ventral striatum of adolescent rats. Behavioural Brain Research. 230: 62-8. PMID 22301350 DOI: 10.1016/J.Bbr.2012.01.036  0.567
2011 Wecker L, Engberg M, Philpot R, Lambert C, Bickford P, Hudson C. Neuronal nicotinic receptor agonists ameliorate 3-acetylpyridine-induced ataxia Biochemical Pharmacology. 82: 1041. DOI: 10.1016/J.Bcp.2011.07.047  0.56
2010 Wecker L, Pollock VV, Pacheco MA, Pastoor T. Nicotine-induced up regulation of α4β2 neuronal nicotinic receptors is mediated by the protein kinase C-dependent phosphorylation of α4 subunits. Neuroscience. 171: 12-22. PMID 20837109 DOI: 10.1016/J.Neuroscience.2010.09.005  0.382
2010 Papke RL, Wecker L, Stitzel JA. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 333: 501-18. PMID 20100906 DOI: 10.1124/Jpet.109.164566  0.343
2009 Philpot RM, Wecker L, Kirstein CL. Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 27: 805-15. PMID 19712739 DOI: 10.1016/J.Ijdevneu.2009.08.009  0.541
2009 Pollock VV, Pastoor T, Katnik C, Cuevas J, Wecker L. Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience. 158: 1311-25. PMID 19101612 DOI: 10.1016/J.Neuroscience.2008.11.032  0.304
2008 Philpot RM, Wecker L. Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling. Behavioral Neuroscience. 122: 861-75. PMID 18729640 DOI: 10.1037/0735-7044.122.4.861  0.527
2006 Trent DeKosky S, Wecker L, Pastoor T, Wuu J, Mufson EJ, Ikonomovic MD. P3-428: Stability of nicotinic acetylcholine receptor binding in the frontal and temporal cortex of subjects with mild cognitive impairment Alzheimer's & Dementia. 2: S502-S502. DOI: 10.1016/J.Jalz.2006.05.1699  0.326
2004 Severance EG, Zhang H, Cruz Y, Pakhlevaniants S, Hadley SH, Amin J, Wecker L, Reed C, Cuevas J. The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. Molecular Pharmacology. 66: 420-9. PMID 15322233 DOI: 10.1124/Mol.104.000059  0.302
2004 Torrella TA, Badanich KA, Philpot RM, Kirstein CL, Wecker L. Developmental differences in nicotine place conditioning. Annals of the New York Academy of Sciences. 1021: 399-403. PMID 15251917 DOI: 10.1196/Annals.1308.052  0.576
2003 Pacheco MA, Pastoor TE, Wecker L. Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Brain Research. Molecular Brain Research. 114: 65-72. PMID 12782394 DOI: 10.1016/S0169-328X(03)00138-4  0.31
2001 Pacheco MA, Pastoor TE, Lukas RJ, Wecker L. Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells. Neurochemical Research. 26: 683-93. PMID 11519728 DOI: 10.1023/A:1010995521851  0.362
1999 Rothschild DM, O'Grady M, Wecker L. Neonatal cytomegalovirus exposure decreases prepulse inhibition in adult rats: implications for schizophrenia. Journal of Neuroscience Research. 57: 429-34. PMID 10440892 DOI: 10.1002/(Sici)1097-4547(19990815)57:4<429::Aid-Jnr2>3.0.Co;2-D  0.326
1999 Gordon MN, Muller CD, Sherman KA, Morgan DG, Azzaro AJ, Wecker L. Oral versus transdermal selegiline: antidepressant-like activity in rats. Pharmacology, Biochemistry, and Behavior. 63: 501-6. PMID 10418793 DOI: 10.1016/S0091-3057(99)00016-7  0.317
1997 Hsu YN, Edwards SC, Wecker L. Nicotine enhances the cyclic AMP-dependent protein kinase-mediated phosphorylation of alpha4 subunits of neuronal nicotinic receptors. Journal of Neurochemistry. 69: 2427-31. PMID 9375675 DOI: 10.1046/J.1471-4159.1997.69062427.X  0.344
1996 Forsyth CS, Speth RC, Wecker L, Galey FD, Frank AA. Comparison of nicotinic receptor binding and biotransformation of coniine in the rat and chick. Toxicology Letters. 89: 175-83. PMID 9001585 DOI: 10.1016/S0378-4274(96)03804-0  0.414
1996 Yu ZJ, Morgan DG, Wecker L. Distribution of three nicotinic receptor alpha 4 mRNA transcripts in rat brain: selective regulation by nicotine administration. Journal of Neurochemistry. 66: 1326-9. PMID 8769902 DOI: 10.1046/J.1471-4159.1996.66031326.X  0.336
1996 Hsu YN, Amin J, Weiss DS, Wecker L. Sustained nicotine exposure differentially affects alpha 3 beta 2 and alpha 4 beta 2 neuronal nicotinic receptors expressed in Xenopus oocytes. Journal of Neurochemistry. 66: 667-75. PMID 8592138 DOI: 10.1046/J.1471-4159.1996.66020667.X  0.318
1994 Yu ZJ, Wecker L. Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. Journal of Neurochemistry. 63: 186-94. PMID 7911509 DOI: 10.1046/J.1471-4159.1994.63010186.X  0.351
1993 Anandatheerthavarada HK, Williams JF, Wecker L. The chronic administration of nicotine induces cytochrome P450 in rat brain. Journal of Neurochemistry. 60: 1941-4. PMID 8473908 DOI: 10.1111/J.1471-4159.1993.Tb13424.X  0.385
1993 Anandatheerthavarada HK, Williams JF, Wecker L. Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1. Biochemical and Biophysical Research Communications. 194: 312-8. PMID 8333846 DOI: 10.1006/Bbrc.1993.1821  0.361
1992 Zawia N, Arendash GW, Wecker L. Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain. Brain Research. 589: 333-7. PMID 1393599 DOI: 10.1016/0006-8993(92)91295-P  0.371
1991 Welsh B, Wecker L. Effects of streptozotocin-induced diabetes on acetylcholine metabolism in rat brain. Neurochemical Research. 16: 453-60. PMID 1833657 DOI: 10.1007/Bf00965566  0.364
1989 Wecker L, Cawley G, Rothermel S. Acute choline supplementation in vivo enhances acetylcholine synthesis in vitro when neurotransmitter release is increased by potassium. Journal of Neurochemistry. 52: 568-75. PMID 2562990 DOI: 10.1111/J.1471-4159.1989.Tb09157.X  0.342
1988 Wecker L. Influence of dietary choline availability and neuronal demand on acetylcholine synthesis by rat brain. Journal of Neurochemistry. 51: 497-504. PMID 3392542 DOI: 10.1111/J.1471-4159.1988.Tb01066.X  0.37
1988 Wecker L, Reinhardt RR. Adenosine inhibits choline kinase activity and decreases the phosphorylation of choline in striatal synaptosomes. Journal of Neurochemistry. 50: 1945-51. PMID 2836562 DOI: 10.1111/J.1471-4159.1988.Tb02501.X  0.315
1987 Flynn CJ, Wecker L. Concomitant increases in the levels of choline and free fatty acids in rat brain: evidence supporting the seizure-induced hydrolysis of phosphatidylcholine. Journal of Neurochemistry. 48: 1178-84. PMID 3819725 DOI: 10.1111/J.1471-4159.1987.Tb05644.X  0.301
1987 Wecker L, Rothermel S, Cawley G. Chronic choline supplementation attenuates the behavioral effects of pentobarbital. Pharmacology, Biochemistry, and Behavior. 28: 469-75. PMID 3432313 DOI: 10.1016/0091-3057(87)90508-9  0.333
1986 Flynn CJ, Wecker L. Elevated choline levels in brain. A non-cholinergic component of organophosphate toxicity. Biochemical Pharmacology. 35: 3115-21. PMID 3753519 DOI: 10.1016/0006-2952(86)90395-3  0.359
1986 Wecker L. Neurochemical effects of choline supplementation. Canadian Journal of Physiology and Pharmacology. 64: 329-33. PMID 3708441 DOI: 10.1139/Y86-054  0.367
1984 Wecker L, Trommer BA. Effects of chronic (dietary) choline availability on the transport of choline across the blood-brain barrier. Journal of Neurochemistry. 43: 1762-5. PMID 6491676 DOI: 10.1111/J.1471-4159.1984.Tb06107.X  0.305
1982 Trommer BA, Schmidt DE, Wecker L. Exogenous choline enhances the synthesis of acetylcholine only under conditions of increased cholinergic neuronal activity. Journal of Neurochemistry. 39: 1704-9. PMID 7142996 DOI: 10.1111/J.1471-4159.1982.Tb08006.X  0.391
1981 Schmidt DE, Wecker L. CNS effects of choline administration: evidence for temporal dependence. Neuropharmacology. 20: 535-9. PMID 7242873 DOI: 10.1016/0028-3908(81)90205-7  0.384
1980 Wecker L, Schmidt DE. Neuropharmacological consequences of choline administration. Brain Research. 184: 234-8. PMID 7357423 DOI: 10.1016/0006-8993(80)90605-8  0.322
1979 Wecker L, Schmidt DE. Central cholinergic function: relationship to choline administration. Life Sciences. 25: 375-84. PMID 470558 DOI: 10.1016/0024-3205(79)90269-8  0.389
1979 Wecker L, Dettbarn WD. Relationship between choline availability and acetylcholine synthesis in discrete regions of rat brain. Journal of Neurochemistry. 32: 961-7. PMID 430073 DOI: 10.1111/J.1471-4159.1979.Tb04581.X  0.353
1978 Wecker L, Dettbarn WD, Schmidt DE. Choline administration: modification of the central actions of atropine. Science (New York, N.Y.). 199: 86-7. PMID 17569493 DOI: 10.1126/Science.199.4324.86  0.381
1977 Wecker L, Mobley PL, Dettbarn WD. Central cholinergic mechanisms underlying adaptation to reduced cholinesterase activity. Biochemical Pharmacology. 26: 633-7. PMID 856193 DOI: 10.1016/0006-2952(77)90037-5  0.357
1973 Wecker L, Chiou CY. Central cholinomimetic actions of 3, 3-dimethyl-1-butanol carbamate. Journal of Pharmaceutical Sciences. 62: 1569-71. PMID 4743120 DOI: 10.1002/Jps.2600620948  0.352
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