Robert E. Handschumacher - Publications

Affiliations: 
Pharmacology Yale University, New Haven, CT 
Website:
http://medicine.yale.edu/pharm/people/REH2.profile

13/181 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1998 Liu MP, Beigelman L, Levy E, Handschumacher RE, Pizzorno G. Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis American Journal of Physiology - Gastrointestinal and Liver Physiology. 274: G1018-G1023. PMID 9696700 DOI: 10.1152/Ajpgi.1998.274.6.G1018  0.309
1996 Li W, Handschumacher RE. Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones Biochemical and Biophysical Research Communications. 219: 96-99. PMID 8619834 DOI: 10.1006/Bbrc.1996.0187  0.3
1984 Merker MP, Merker MM, Handschumacher RE. Uptake and nature of the intracellular binding of cyclosporin A in a murine thymoma cell line, BW5147. Journal of Immunology (Baltimore, Md. : 1950). 132: 3064-70. PMID 6609967 DOI: 10.4049/Jimmunol.1390062  0.301
1984 Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW. Cyclophilin: A specific cytosolic binding protein for cyclosporin A Science. 226: 544-547. PMID 6238408 DOI: 10.1126/Science.6238408  0.319
1979 Handschumacher RE, Coleridge J. Hepatic and biliary transport of orotate and its metabolic consequences Biochemical Pharmacology. 28: 1977-1981. PMID 454468 DOI: 10.1016/0006-2952(79)90654-3  0.306
1968 Rajalakshmi S, Handschumacher RE. Control of purine biosynthesis de novo by orotic acid in vivo and in vitro Bba Section Nucleic Acids and Protein Synthesis. 155: 317-325. PMID 5637062 DOI: 10.1016/0005-2787(68)90176-7  0.324
1954 Buyske DA, Handschumacher RE, Schilling ED, Strong FM. The stability of coenzyme A Journal of the American Chemical Society. 76: 3575-3577. DOI: 10.1021/ja01642a065  0.433
1953 BEINERT H, VON KORFF RW, GREEN DE, BUYSKE DA, HANDSCHUMACHER RE, HIGGINS H, STRONG FM. A method for the purification of coenzyme A from yeast. The Journal of Biological Chemistry. 200: 385-400. PMID 13034796  0.483
1952 Beinert H, Von Korff RW, Green DE, Buyske DA, Handschumacher RE, Higgins H, Strong FM. A METHOD FOR PURIFICATION OF COENZYME A Journal of the American Chemical Society. 74: 854-855. DOI: 10.1021/Ja01123A531  0.479
1952 Beinert H, Von Korff RW, Green DE, Buyske DA, Handschumacher RE, Higgins H, Strong FM. A method for purification of coenzyme A [2] Journal of the American Chemical Society. 74: 854-855.  0.479
1951 BUYSKE DM, HANDSCHUMACHER RE, HIGGINS H, KING TE, STRONG FM, CHELDELIN VH, TEPLY LJ, MUELLER GC. Preparation and purification of coenzyme A concentrates. The Journal of Biological Chemistry. 193: 307-16. PMID 14907718  0.486
1951 HANDSCHUMACHER RE, MUELLER GC, STRONG FM. An improved enzymatic assay for coenzyme A. The Journal of Biological Chemistry. 189: 335-42. PMID 14832246  0.452
1950 NEILANDS JB, HIGGINS H, KING TE, HANDSCHUMACHER RE, STRONG FM. Concentration of bound pantothenic acid. The Journal of Biological Chemistry. 185: 335-46. PMID 15436506  0.599
Low-probability matches (unlikely to be authored by this person)
2001 Russell RL, Cao D, Zhang D, Handschumacher RE, Pizzorno G. Uridine phosphorylase association with vimentin. Intracellular distribution and localization. The Journal of Biological Chemistry. 276: 13302-7. PMID 11278417 DOI: 10.1074/Jbc.M008512200  0.299
1991 Sokoloski JA, Lee CW, Handschumacher RE, Nigam A, Sartorelli AC. Effects of uridine on the growth and differentiation of HL-60 leukemia cells Leukemia Research. 15: 1051-1058. PMID 1961008 DOI: 10.1016/0145-2126(91)90111-6  0.295
1962 Rubin RJ, Jaffe JJ, Handschumacher RE. Qualitative differences in the pyrimidine metabolism of Trypanosoma equiperdum and mammals as characterized by 6-azauracil and 6-azauridine Biochemical Pharmacology. 11: 563-572. DOI: 10.1016/0006-2952(62)90117-X  0.294
1991 Darnowski JW, Handschumacher RE, Wiegand RA, Goulette FA, Calabresi P. Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine Biochemical Pharmacology. 41: 2031-2036. PMID 2039551 DOI: 10.1016/0006-2952(91)90146-V  0.293
1969 Solter AW, Handschumacher RE. A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA Bba Section Nucleic Acids and Protein Synthesis. 174: 585-590. PMID 4975704 DOI: 10.1016/0005-2787(69)90288-3  0.291
1988 Handschumacher RE, Harding MW. Cyclophilin, a primary molecular target for cyclosporine: Structural and functional im plications Transplantation. 46: 29S-35S. PMID 3043795 DOI: 10.1097/00007890-198808001-00006  0.29
1992 Sarris AH, Harding MW, Jiang TR, Aftab D, Handschumacher RE. Immunofluorescent localization and immunochemical determination of cyclophilin-A with specific rabbit antisera Transplantation. 54: 904-910. PMID 1440857 DOI: 10.1097/00007890-199211000-00026  0.289
1995 Pizzorno G, Handschumacher RE. Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines Biochemical Pharmacology. 49: 559-565. PMID 7872962 DOI: 10.1016/0006-2952(94)00445-R  0.289
1990 Hsu VL, Heald SL, Harding MW, Handschumacher RE, Armitage IM. Structural elements pertinent to the interaction of cyclosporin A with its specific receptor protein, cyclophilin. Biochemical Pharmacology. 40: 131-40. PMID 2196880 DOI: 10.1016/0006-2952(90)90188-Q  0.288
1992 Thalhammer T, Kieffer LJ, Jiang T, Handschumacher RE. Isolation and partial characterization of membrane-associated cyclophilin and a related 22-kDa glycoprotein European Journal of Biochemistry. 206: 31-37. PMID 1587281 DOI: 10.1111/J.1432-1033.1992.Tb16898.X  0.288
1991 Sokoloski JA, Sartorelli AC, Handschumacher RE, Lee CW. Inhibition by pertussis toxin of the activation of Na+-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells Biochemical Journal. 280: 515-519. PMID 1747127 DOI: 10.1042/Bj2800515  0.287
1971 Summers WP, Handschumacher RE. L5178Y asparagine-dependent cells and independent clonal sublines. Toxicity of 5-diazo-4-oxo-L-norvaline. Biochemical Pharmacology. 20: 2213-20. PMID 5293485 DOI: 10.1016/0006-2952(71)90220-6  0.286
1989 Darnowski JW, Handschumacher RE. Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools Pharmacology and Therapeutics. 41: 381-392. PMID 2652156 DOI: 10.1016/0163-7258(89)90115-0  0.284
1995 Hoffmann K, Kakalis LT, Anderson KS, Armitage IM, Handschumacher RE. Expression of human cyclophilin-40 and the effect of the His141 → Trp mutation on catalysis and cyclosporin A binding Febs Journal. 229: 188-193. DOI: 10.1111/J.1432-1033.1995.0188L.X  0.281
1991 Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE. Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na+-dependent uridine-transport system. Involvement of protein kinase C Biochemical Journal. 274: 85-90. PMID 2001255 DOI: 10.1042/Bj2740085  0.281
1989 Hait WN, Stein JM, Koletsky AJ, Harding MW, Handschumacher RE. Activity of cyclosporin A and a non-immunosuppressive cyclosporin against multidrug resistant leukemic cell lines. Cancer Communications. 1: 35-43. PMID 2640154 DOI: 10.3727/095535489820875462  0.279
1979 Chang PK, Lachman LB, Handschumacher RE. Synthesis of model compounds relevant to the active-site-directed inactivation of L-asparaginase by 5-diazo-4-oxo-L-norvaline. International Journal of Peptide and Protein Research. 14: 27-33. PMID 385521 DOI: 10.1111/J.1399-3011.1979.Tb01917.X  0.273
1985 Schwartz PM, Moir RD, Hyde CM, Turek PJ, Handschumacher RE. Role of uridine phosphorylase in the anabolism of 5-fluorouracil Biochemical Pharmacology. 34: 3585-3589. PMID 2996553 DOI: 10.1016/0006-2952(85)90737-3  0.272
1995 Conrad Schwab J, Afifi Afifi M, Pizzorno G, Handschumacher RE, Joiner KA. Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter Molecular and Biochemical Parasitology. 70: 59-69. PMID 7637715 DOI: 10.1016/0166-6851(95)00005-L  0.272
1972 Chou TC, Handschumacher RE. Production of L-asparagine by tumor cells and the effect of asparagine analogs. Biochemical Pharmacology. 21: 39-48. PMID 4333695 DOI: 10.1016/0006-2952(72)90248-1  0.272
1981 Gasser T, Moyer JD, Handschumacher RE. Novel single-pass exchange of circulating uridine in rat liver Science. 213: 777-778. PMID 7256279 DOI: 10.1126/Science.7256279  0.267
1995 Hoffmann K, Handschumacher RE. Cyclophilin-40: Evidence for a dimeric complex with hsp90 Biochemical Journal. 307: 5-8. PMID 7717993 DOI: 10.1042/Bj3070005  0.267
1974 Gery I, Handschumacher RE. Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells. Cellular Immunology. 11: 162-9. PMID 4549027 DOI: 10.1016/0008-8749(74)90016-1  0.267
1976 Lachman LB, Handschumacher RE. The active site of L-asparaginase: dimethylsulfoxide effect of 5-diazo-4-oxo-L-norvaline interactions. Biochemical and Biophysical Research Communications. 73: 1094-100. PMID 15625886 DOI: 10.1016/0006-291X(76)90235-7  0.266
2002 Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D, Handschumacher RE. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochimica Et Biophysica Acta. 1587: 133-44. PMID 12084455 DOI: 10.1016/S0925-4439(02)00076-5  0.266
1977 Lachman LB, Hacker MP, Blyden GT, Handschumacher RE. Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines Cellular Immunology. 34: 416-419. PMID 563294 DOI: 10.1016/0008-8749(77)90263-5  0.265
1967 Reynard AM, Handschumacher RE. The decarboxylation of 5-azaorotic acid Journal of Heterocyclic Chemistry. 4: 453-457. DOI: 10.1002/Jhet.5570040336  0.262
1988 Darnowski JW, Handschumacher RE. Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice Biochemical Pharmacology. 37: 2613-2618. PMID 3390221 DOI: 10.1016/0006-2952(88)90254-7  0.259
1969 Rajalakshmi S, Adams WR, Handschumacher RE. Isolation and characterization of low density structures from orotic acid-induced fatty livers Journal of Cell Biology. 41: 625-636. PMID 5783877 DOI: 10.1083/Jcb.41.2.625  0.259
1963 Skoda J, Handschumacher RE. The influence of certain antimetabolites on the incorporation of orotic acid into pseudouridine in animals Bba Specialized Section On Nucleic Acids and Related Subjects. 68: 481-483. PMID 13977932 DOI: 10.1016/0926-6550(63)90466-3  0.256
1991 Marks WH, Harding MW, Handschumacher R, Marks C, Lorber MI. The immunochemical distribution of cyclophilin in normal mammalian tissues Transplantation. 52: 340-345. PMID 1871809 DOI: 10.1097/00007890-199108000-00030  0.256
1986 Dalgarno DC, Harding MW, Lazarides A, Handschumacher RE, Armitage IM. 1H NMR studies on bovine cyclophilin: preliminary structural characterization of this specific cyclosporin A binding protein. Biochemistry. 25: 6778-84. PMID 3542017 DOI: 10.1021/Bi00370A008  0.255
1968 Handschumacher RE, Bates CJ, Chang PK, Andrews AT, Fischer GA. 5-Diazo-4-oxo-L-norvaline: reactive asparagine analog with biological specificity. Science (New York, N.Y.). 161: 62-3. PMID 5240831 DOI: 10.1126/Science.161.3836.62  0.251
1999 Liu M, Russell RL, Beigelman L, Handschumacher RE, Pizzorno G. beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. The American Journal of Physiology. 276: G206-10. PMID 9886997 DOI: 10.1152/Ajpgi.1999.276.1.G206  0.25
1977 Handschumacher RE. Some considerations in the design of new antineoplastic agents Cancer. 40: 529-533. PMID 884650 DOI: 10.1002/1097-0142(197707)40:1+<529::Aid-Cncr2820400719>3.0.Co;2-0  0.25
1977 Uren JR, Chang PK, Handschumacher RE. Effects of asparagine synthetase inhibitors on asparaginase resistant tumors Biochemical Pharmacology. 26: 1405-1410. PMID 20104 DOI: 10.1016/0006-2952(77)90365-3  0.247
1990 Heald SL, Harding MW, Handschumacher RE, Armitage IM. 1H NMR studies on bovine cyclophilin: preliminary structural characterization of its complex with cyclosporin A. Biochemistry. 29: 4466-78. PMID 2190633 DOI: 10.1021/Bi00470A029  0.246
2002 Li W, Handschumacher RE. Identification of two calcineurin B-binding proteins: Tubulin and heat shock protein 60 Biochimica Et Biophysica Acta - Proteins and Proteomics. 1599: 72-81. PMID 12479407 DOI: 10.1016/S1570-9639(02)00402-8  0.245
1976 Lachman LB, Blyden GT, Hacker M, Handschumacher RE. Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes Cellular Immunology. 27: 354. DOI: 10.1016/0008-8749(76)90306-3  0.244
1995 Pizzorno G, Sun Z, Handschumacher RE. Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil Biochemical Pharmacology. 49: 553-557. PMID 7872961 DOI: 10.1016/0006-2952(94)00444-Q  0.241
1963 Rupp WD, Handschumacher RE. Two different metabolic fates of 5-ethyl-6-azauracil in mice Biochemical Pharmacology. 12: 13-18. PMID 13975570 DOI: 10.1016/0006-2952(63)90004-2  0.239
1995 Owens-Grillo JK, Hoffmann K, Hutchison KA, Yem AW, Deibel MR, Handschumacher RE, Pratt WB. The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor. The Journal of Biological Chemistry. 270: 20479-84. PMID 7657624 DOI: 10.1074/Jbc.270.35.20479  0.238
1979 Diamantstein T, Oppenheim JJ, Unanue ER, Wood DD, Handschumacher RE, Rosenstreich DL, Waksman BH. Nonspecific "lymphocyte activating" factors produced by macrophages. Clinical Immunology and Immunopathology. 14: 264-7. PMID 226303 DOI: 10.1016/0090-1229(79)90149-1  0.228
1979 Diamantstein T, Oppenheim JJ, Unanue ER, Wood DD, Handschumacher RE, Rosenstreich DL, Waksman BH. Nonspecific "lymphocyte activating" factors produced by macrophages. Cellular Immunology. 46: 422-5. PMID 226274 DOI: 10.1016/0008-8749(79)90430-1  0.228
1997 McCornack MA, Kakalis LT, Caserta C, Handschumacher RE, Armitage IM. HIV protease substrate conformation: modulation by cyclophilin A. Febs Letters. 414: 84-8. PMID 9305737 DOI: 10.1016/S0014-5793(97)00974-5  0.228
1966 Markoff LJ, Handschumacher RE. Enzymatic formation of uracil and azauriail nucleotides in Streptococcus faecalis Biochemical Pharmacology. 15: 761-763. PMID 4960469 DOI: 10.1016/0006-2952(66)90015-3  0.225
1986 Hait WN, Harding MW, Handschumacher RE. Calmodulin, cyclophilin, and cyclosporin A Science. 233: 987-989. PMID 3016900 DOI: 10.1126/Science.3016900  0.213
1994 Boros LG, De Corte B, Gimi RH, Welch JT, Wu Y, Handschumacher RE. Fluoroolefin peptide isosteres - tools for controlling peptide conformations Tetrahedron Letters. 35: 6033-6036. DOI: 10.1016/0040-4039(94)88067-0  0.209
1991 Murren JR, Ganpule S, Sarris A, Durivage H, Davis C, Makuch R, Handschumacher RE, Marsh JC. A phase II trial of cyclosporin A in the treatment of refractory metastatic colorectal cancer American Journal of Clinical Oncology: Cancer Clinical Trials. 14: 208-210. PMID 2031507 DOI: 10.1097/00000421-199106000-00007  0.207
1990 Hsu VL, Handschumacher RE, Armitage IM. Peptidyl-prolyl cis-trans isomerase activity of cyclophilin studied by one-dimensional proton nuclear magnetic resonance spectroscopy Journal of the American Chemical Society. 112: 6745-6747. DOI: 10.1021/Ja00174A064  0.202
1992 Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR. Leukocyte chemotactic activity of cyclophilin Journal of Biological Chemistry. 267: 11968-11971. PMID 1601866  0.201
1997 Chambers SK, Chambers JT, Davis CA, Kohorn EI, Schwartz PE, Lorber MI, Handschumacher RE, Pizzorno G. Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients Journal of Clinical Oncology. 15: 1945-1952. PMID 9164206 DOI: 10.1200/Jco.1997.15.5.1945  0.197
1957 Handschumacher RE. Studies of bacterial resistance to 6-azauracil and its riboside Bba - Biochimica Et Biophysica Acta. 23: 428-430. DOI: 10.1016/0006-3002(57)90348-7  0.19
1970 van Wagenen G, DeConti RC, Handschumacher RE, Wade ME. Abortifacient and teratogenic effects of triacetyl-6-azauridine in the monkey. American Journal of Obstetrics and Gynecology. 108: 272-81. PMID 4952580 DOI: 10.1016/0002-9378(70)90310-8  0.19
1990 Handschumacher RE, Armitage IM. An overview of recent progress in ligand-receptor research based on nuclear magnetic resonance spectroscopy. Biochemical Pharmacology. 40: 3-5. PMID 2372308 DOI: 10.1016/0006-2952(90)90170-P  0.188
1987 Darnowski JW, Holdridge C, Handschumacher RE. Concentrative uridine transport by murine splenocytes: Kinetics, substrate specificity, and sodium dependency Cancer Research. 47: 2614-2619. PMID 3567894  0.181
1986 Darnowski JW, Handschumacher RE. Tissue uridine pools: Evidence in vivo of a concentrative mechanism for uridine uptake Cancer Research. 46: 3490-3494. PMID 3708581  0.172
1974 Handschumacher RE. Aspects of pharmacology pertinent to the skin. Clinical Pharmacology and Therapeutics. 16: 865-8. PMID 4278550 DOI: 10.1002/Cpt1974165Part2865  0.171
1985 Sobrero AF, Handschumacher RE, Bertino JR. Highly selective drug combination for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine Cancer Research. 45: 3161-3163. PMID 3159475  0.17
1986 Koletsky AJ, Harding MW, Handschumacher RE. Cyclophilin: Distribution and variant properties in normal and neoplastic tissues Journal of Immunology. 137: 1054-1059. PMID 3522735  0.165
1994 High KP, Joiner KA, Handschumacher RE. Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii Journal of Biological Chemistry. 269: 9105-9112. PMID 8132648  0.165
1986 Harding MW, Handschumacher RE, Speicher DW. Isolation and amino acid sequence of cyclophilin Journal of Biological Chemistry. 261: 8547-8555. PMID 3522572  0.165
1960 HANDSCHUMACHER RE. Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate The Journal of Biological Chemistry. 235: 2917-2919. PMID 13711194  0.163
1995 Lee CW, Handschumacher RE. Concentrative transport of adenosine in murine splenocytes: Limitation by an ecto-adenosine deaminase In Vivo. 9: 1-6. PMID 7669942  0.159
1998 Liu M, Cao D, Russell R, Handschumacher RE, Pizzorno G. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors Cancer Research. 58: 5418-5424. PMID 9850074  0.158
1995 Hoffmann K, Kakalis LT, Anderson KS, Armitage IM, Handschumacher RE. Expression of human cyclophilin-40 and the effect of the His141-->Trp mutation on catalysis and cyclosporin A binding. European Journal of Biochemistry / Febs. 229: 188-93. PMID 7744028 DOI: 10.1111/j.1432-1033.1995.tb20454.x  0.155
1995 Renoir JM, Mercier-Bodard C, Hoffmann K, Le Bihan S, Ning YM, Sanchez ER, Handschumacher RE, Baulieu EE. Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: A possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression Proceedings of the National Academy of Sciences of the United States of America. 92: 4977-4981. PMID 7539138 DOI: 10.1073/pnas.92.11.4977  0.155
1977 Blyden G, Handschumacher RE. Purification and properties of human lymphocyte activating factor (LAF) Journal of Immunology. 118: 1631-1638. PMID 300751  0.153
1985 Sobrero AF, Moir RD, Bertino JR, Handschumacher RE. Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line Cancer Research. 45: 3155-3160. PMID 3159474  0.152
1994 Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE. Differentiation of HL-60 cells by dimethylsulfoxide activates a Na+-dependent nucleoside transport system In Vivo. 8: 795-802. PMID 7727727  0.149
1982 Moyer JD, Smith PA, Levy EJ, Handschumacher RE. Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells Cancer Research. 42: 4525-4531. PMID 7127293  0.148
1993 Kieffer LJ, Seng TW, Li W, Osterman DG, Handschumacher RE, Bayney RM. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex: Cloning of the cDNA and further characterization Journal of Biological Chemistry. 268: 12303-12310. PMID 8509368  0.147
1981 Moyer JD, Oliver JT, Handschumacher RE. Salvage of circulating pyrimidine nucleosides in the rat Cancer Research. 41: 3010-3017. PMID 7248957  0.146
1977 Lachman LB, Hacker MP, Handschumacher RE. Partial purification of human lymphocyte-activating factor (LAF) by ultrafiltration and electrophoretic techniques Journal of Immunology. 119: 2019-2023. PMID 915290  0.144
1998 Pizzorno G, Yee L, Burtness BA, Marsh JC, Darnowski JW, Chu MYW, Chu SH, Chu E, Leffert JJ, Handschumacher RE, Calabresi P. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor Clinical Cancer Research. 4: 1165-1175. PMID 9607574  0.143
1989 Chambers SK, Hait WN, Kacinski BM, Keyes SR, Handschumacher RE. Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues Cancer Research. 49: 6275-6279. PMID 2804973  0.142
1977 Peterson RG, Richards FF, Handschumacher RE. Structure of peptide from active site region of Escherichia coli L-asparaginase. The Journal of Biological Chemistry. 252: 2072-6. PMID 321449  0.135
1985 Darnowski w. J, Handschumacher RE. Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine Cancer Research. 45: 5364-5368. PMID 4053009  0.135
1963 HANDSCHUMACHER RE. 5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides Cancer Research. 23: 634-639. PMID 13952504  0.128
1992 Kieffer LJ, Thalhammer T, Handschumacher RE. Isolation and characterization of a 40-kDa cyclophilin-related protein Journal of Biological Chemistry. 267: 5503-5507. PMID 1544925  0.128
1964 HANDSCHUMACHER RE, FISCHER GA. METHODS FOR DETERMINATION OF PERMEABILITY OF CELLS TO DRUGS Methods in Medical Research. 10: 269-276. PMID 14284930  0.127
1958 Handschumacher RE, Pasternak CA. Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil Bba - Biochimica Et Biophysica Acta. 30: 451-452.  0.125
1992 Pizzorno G, Wiegand RA, Lentz SK, Handschumacher RE. Brequinar potentiates 5-fluorouracil antitumor activity in a murine model Colon 38 tumor by tissue-specific modulation of uridine nucleotide pools Cancer Research. 52: 1660-1665. PMID 1551097  0.123
1966 Brown NC, Handschumacher RE. Inhibition of the synthesis of deoxyribonucleic acid in bacteria by 6-(p-hydroxyphenylazo)-2,4-dihydroxypyrimidine. I. Metabolic studies in Streptococcus fecalis. The Journal of Biological Chemistry. 241: 3083-9. PMID 4957971  0.121
1979 Dix DE, Lehman CP, Jakubowski A, Moyer JD, Handschumacher RE. Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells Cancer Research. 39: 4485-4490. PMID 498080  0.12
2013 Merker MP, Handschumacher RE. Uptake and nature of the intracellular binding of cyclosporin a in a murine thymoma cell line, BW5147 (Journal of Immunology (1984) 132 (3064-3070)) Journal of Immunology. 191: 5778. DOI: 10.4049/jimmunol.1390062  0.116
1996 Zhu Z, Sokoloski JA, Liu MP, Sartorelli AC, Handschumacher RE. Pyrimidine phosphorylase activity in differentiating HL-60 leukemia cells Molecular and Cellular Differentiation. 4: 263-274.  0.116
1990 London RE, Davis DG, Vavrek RJ, Stewart JM, Handschumacher RE. Bradykinin and its Gly6 analogue are substrates of cyclophilin: a fluorine-19 magnetization transfer study. Biochemistry. 29: 10298-302. PMID 2261473  0.115
1960 Handschumacher RE, Creasey WA, Jaffe JJ, Pasternak CA, Hankin L. BIOCHEMICAL AND NUTRITIONAL STUDIES ON THE INDUCTION OF FATTY LIVERS BY DIETARY OROTIC ACID. Proceedings of the National Academy of Sciences of the United States of America. 46: 178-86. PMID 16590605 DOI: 10.1073/pnas.46.2.178  0.109
1973 Coleman JE, Handschumacher RE. Asparaginase. Stereochemistry of the active center as determined by circular dichroism of substrates. The Journal of Biological Chemistry. 248: 1741-5. PMID 4571775  0.109
1992 High KP, Handschumacher RE. Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? Infectious Agents and Disease. 1: 121-135. PMID 1285413  0.109
1963 VON EULER LH, RUBIN RJ, HANDSCHUMACHER RE. Fatty livers induced by orotic acid. II. Changes in nucleotide metabolism The Journal of Biological Chemistry. 238: 2464-2469. PMID 13997860  0.107
1978 Moyer JD, Handschumacher RE. Selective N-(phosphonoacetyl)-L-aspartate induced alterations of pyrimidine biosynthesis and nucleotide concentrations in mice Federation Proceedings. 37: No. 164.  0.104
1961 CREASEY WA, HANKIN L, HANDSCHUMACHER RE. Fatty livers induced by orotic acid. I. Accumulation and metabolism of lipids The Journal of Biological Chemistry. 236: 2064-2070. PMID 13696348  0.104
1996 Chambers SK, Davis CA, Chambers JT, Schwartz PE, Lorber MI, Handschumacher RE. Phase I trial of intravenous carboplatin and cyclosporin A in refractory gynecologic cancer patients Clinical Cancer Research. 2: 1699-1704. PMID 9816119  0.099
1999 Cao D, Nimmakayalu MA, Wang F, Zhang D, Handschumacher RE, Bray-Ward P, Pizzorno G. Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene Cancer Research. 59: 4997-5001. PMID 10519414  0.098
1980 Schwartz PM, Dunigan JM, Marsh JC, Handschumacher RE. Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil Cancer Research. 40: 1885-1889. PMID 7371020  0.097
1970 Jackson RC, Handschumacher RE. Escherichia coli L-asparaginase. Catalytic activity and subunit nature Biochemistry. 9: 3585-3590. PMID 4928351  0.096
1990 Palu G, Handschumacher RE, Parolin C, Stefanelli S, Palatini P. Effect of herpes simplex virus type 1 infection on nucleoside transport in HeLa S3 cells Journal of General Virology. 71: 673-679. PMID 2156000  0.094
1985 Schwartz PM, Turek PJ, Hyde CM, Cadman EC, Handschumacher RE. Altered plasma kinetics of 5-FU at high dosage in rat and man Cancer Treatment Reports. 69: 133-136. PMID 3967255  0.092
1979 Moyer JD, Handschumacher RE. Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate Cancer Research. 39: 3089-3094. PMID 455293  0.089
1961 PASTERNAK CA, FISCHER GA, HANDSCHUMACHER RE. Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant Cancer Research. 21: 110-117. PMID 13733201  0.088
1965 JATLOW P, ADAMS WR, HANDSCHUMACHER RE. PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES The American Journal of Pathology. 47: 125-145. PMID 14308133  0.087
1971 Peterson RG, Handschumacher RE, Mitchell MS. Immunological responses to L-asparaginase. The Journal of Clinical Investigation. 50: 1080-90. PMID 4101590 DOI: 10.1172/JCI106579  0.087
1983 Merker M, Rice J, Schweitzer B, Handschumacher RE. Cyclosporin binding component in BW5147 lymphoblasts and normal lymphoid tissue Transplantation Proceedings. 15: 2265-2270.  0.086
1982 Schwartz PM, Hyde CM, Komp DM, Handschumacher RE. Analysis of activities for alternate activation of 5-fluorouracil (FU) by 1-pyrophosphoribosyl-5-phosphate (PPRP) and ribose-1-phosphate (R-1-P) in bone marrow and tumor tissues Proceedings of the American Association For Cancer Research. No. 780.  0.086
1979 Diamantstein T, Handschumacher RE, Oppenheim JJ, Rosenstreich DL, Unanue ER, Waksman BH, Wood DD. Nonspecific "lymphocyte activating" factors produced by macrophages. Journal of Immunology (Baltimore, Md. : 1950). 122: 2633-5. PMID 312872  0.085
1995 Liu MP, Handschumacher RE. Tamoxifen induces Na+ -dependent uridine transport and dome formation in a human breast tumor cell line. The Cancer Journal From Scientific American.. 1: 210-214. PMID 9166478  0.085
1993 Li W, Handschumacher RE. Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin Journal of Biological Chemistry. 268: 14040-14044. PMID 7686148  0.083
1958 Handschumacher RE. Bacterial preparation of orotidine-5′-phosphate and uridine-5′-phosphate Nature. 182: 1090-1091. PMID 13590232 DOI: 10.1038/1821090a0  0.075
1959 PASTERNAK CA, HANDSCHUMACHER RE. The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors The Journal of Biological Chemistry. 234: 2992-2997. PMID 14430761  0.075
1982 Merker M, Yu LM, Sherman DH, Handschumacher RE. Examination of the action of cyclosporin A (CyA) on a malignant T cell line, BW5147 Federation Proceedings. 41: 4509.  0.074
1985 Harding MW, Speicher DW, Horowitz M, Handschumacher RE. Cyclophilin: Biological activity and structure Federation Proceedings. 44: No. 3162.  0.074
1975 Dix D, Handschumacher RE. Tumor cell lysis by disruption of sulfhydryl disulfide equilibra Federation Proceedings. 34: No.3316.  0.073
1973 Summers WP, Handschumacher RE. The rate of mutation of L5178Y asparagine-dependent mouse leukemia cells to asparagine independence and its biological consequences. Cancer Research. 33: 1775-9. PMID 4516009  0.073
1969 Handschumacher RE. Structural and regulatory aspects of enzymes in chemotherapy Cancer Research. 29: 2466-2468. PMID 4313006  0.071
1977 Handschumacher RE. Active site of L-asparaginase: reaction with diazo-4-oxonorvaline. Methods in Enzymology. 46: 432-5. PMID 909434  0.071
1977 Handschumacher RE. [47] Active site of l-asparaginase: Reaction with diazo-4-oxonorvaline Methods in Enzymology. 46: 432-435. DOI: 10.1016/S0076-6879(77)46051-8  0.071
1989 Chambers S, Hait W, Handschumacher R. Augmentation of doxorubicin and 4' epidoxorubicin in parental and multidrug-resistant chinese hamster ovary cell lines by cyclosporin A and its nonimmunosuppressive homologs Gynecologic Oncology. 32: 117-118. DOI: 10.1016/0090-8258(89)90959-1  0.071
1973 Handschumacher RE, Hare LE. Mechanisms of drug-enzyme interactions. Anesthesiology. 39: 165-77. PMID 4198288  0.07
1969 Bates CJ, Handschumacher RE. Inactivation and resynthesis of glucosamine-6-phosphate synthetase after treatment with glutamine analogs Advances in Enzyme Regulation. 7: 183-204. PMID 5367804  0.07
1966 Bates CJ, Adams WR, Handschumacher RE. Control of the formation of uridine diphospho-N-acetyl-hexosamine and glycoprotein synthesis in rat liver Journal of Biological Chemistry. 241: 1705-1712. PMID 5945845  0.07
1990 Lorber MI, Paul K, Harding MW, Handschumacher RE, Marks MH. Cyclophilin binding: A receptor-mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation Transplantation Proceedings. 22: 1240-1244. PMID 2190386  0.069
1981 Gasser T, Handschumacher RE. A unique mode of plasma uridine regulation: The complete single pass exchange of circulating uridine in rat liver Proceedings of the American Association For Cancer Research. 125.  0.069
1973 Woods JS, Handschumacher RE. Hepatic regulation of plasma L-asparagine. The American Journal of Physiology. 224: 740-5. PMID 4698791  0.065
1979 Handschumacher RE. Analysis of T cell ontogeny in mitogenized thymocyte populations by cyclosporin A Federation Proceedings. 38: No. 4607.  0.065
1971 Woods JS, Handschumacher RE. Hepatic homeostasis of plasma L-asparagine. The American Journal of Physiology. 221: 1785-90. PMID 5124324  0.064
1992 Kratz A, Harding MW, Craft J, Mackworth-Young CG, Handschumacher RE. Autoantibodies against cyclophillin in systemic lupus erythematosus and Lyme disease Clinical and Experimental Immunology. 90: 422-427. PMID 1458678 DOI: 10.1111/J.1365-2249.1992.Tb05862.X  0.064
1996 Li W, Handschumacher RE. Alternative protein ligands of calcineurin b: Ca++dependent interaction with tubulin and heat shock protein 60 Faseb Journal. 10: A413.  0.064
1985 Koletsky AJ, Harding MW, Handschumacher RE. Cyclophilin: Content and physical properties in normal human and neoplastic tissues Proceedings of the American Association For Cancer Research. No. 598.  0.063
1961 CREASEY WA, HANDSCHUMACHER RE. Purification and properties of orotidylate decarboxylases from yeast and rat liver The Journal of Biological Chemistry. 236: 2058-2063. PMID 13696347  0.063
1991 Paul K, Harding MW, Marks WH, Handschumacher RE, Lorber MI. Cyclophilin binding: A more accurate measure of cyclosporine immunosuppressive activity after renal transplantation Transplantation Proceedings. 23: 974-975. PMID 1989349  0.062
1956 Baddiley J, Buchanan JG, Handschumacher RE, Prescott JF. Chemical studies in the biosynthesis of purine nucleotides. Part I. The preparation of n-glycylglycosylamines Journal of the Chemical Society (Resumed). 2784-2789.  0.062
1964 HANDSCHUMACHER RE. DETERMINATION OF ALTERATIONS IN METABOLISM OF PYRIMIDINES AND THEIR ANALOGS Methods in Medical Research. 10: 277-284. PMID 14284931  0.059
1970 Cooney DA, Capizzi RL, Handschumacher RE. Evaluation of L-asparagine metabolism in animals and man Cancer Research. 30: 929-935. PMID 5537323  0.059
1971 Capizzi RL, Bertino JR, Skeel RT, Creasey WA, Zanes R, Olayon C, Peterson RG, Handschumacher RE. L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Annals of Internal Medicine. 74: 893-901. PMID 5281051 DOI: 10.7326/0003-4819-74-6-893  0.059
1970 Cooney DA, Handschumacher RE. L-asparaginase and L-asparagine metabolism Annual Review of Pharmacology. 10: 421-440. PMID 4911021  0.059
1976 Cadman EC, Dix DE, Hill SC, Handschumacher RE. Pyrazofurin: biochemical and clinicopharmacological studies Proceedings of the American Association For Cancer Research. no. 832.  0.056
1982 Levy EJ, Gasser T, Dreyer RN, Handschumacher RE. Control of the turnover and utilization of circulating uridine by liver bypass, nitrobenzylthioinosine-PO4 or benzyl acyclouridine Proceedings of the American Association For Cancer Research. No. 836.  0.056
1990 Hsu VL, Handschumacher RE, Armitage IM. Peptidyl-prolyl cis-trans isomerase activity of cyclophilin studied by One-Dimensional1H nuclear magnetic resonance spectroscopy Journal of the American Chemical Society. 112: 6745-6747.  0.054
1978 Schwartz PM, Handschumacher RE. Antagonism of 5-fluorouracil (5FU) growth inhibition and toxicity by allopurinol (AL) and pyrazofurin (PF) Proceedings of the American Association For Cancer Research. No. 441.  0.052
1972 Handschumacher RE, Gaumond C. Modification of L-asparaginase by subunit cross-linking with dimethylsuberimidate. Molecular Pharmacology. 8: 59-64. PMID 4551473  0.052
1972 Liu YP, Handschumacher RE. Nitroasparaginase. Subunit cross-linkage and altered substrate specificity. The Journal of Biological Chemistry. 247: 66-9. PMID 4552927  0.051
1960 WELCH AD, HANDSCHUMACHER RE, JAFFE JJ. Studies on the pharmacology of 6-azauracil. The Journal of Pharmacology and Experimental Therapeutics. 129: 262-270. PMID 13843819  0.048
1974 Uren JR, Summers WP, Handschumacher RE. Enzymatic and nutritional evidence for two-stage exression of the asparagine synthetase locus in L5178y murine leukemia mutants. Cancer Research. 34: 2940-5. PMID 4529293  0.048
1973 Hare LE, Handschumacher RE. Physical and biological properties of acetamidino-, beta-dimethylaminopropionamidino-, and maleyl-L-asparaginase. Molecular Pharmacology. 9: 534-41. PMID 4579920  0.048
1964 RUBIN RJ, REYNARD A, HANDSCHUMACHER RE. AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF Cancer Research. 24: 1002-1007. PMID 14195336  0.047
1960 HANDSCHUMACHER RE. Azauracil ribonucleoside and ribonucleotides: isolation and chemical synthesis The Journal of Biological Chemistry. 235: 764-768. PMID 14399459  0.046
1965 Handschumacher RE. Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy Cancer Research. 25: 1541-1543. PMID 5861077  0.045
1961 CARDOSO SS, CALABRESI P, HANDSCHUMACHER RE. Alterations in human pyrimidine metabolism as a result of therapy with 6-azauridine Cancer Research. 21: 1551-1556.  0.043
1979 Schwartz PM, Handschumacher RE. Selective antagonism of 5-fluorouracil cytoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro Cancer Research. 39: 3095-3101. PMID 455294  0.042
1978 Cadman EC, Dix DE, Handschumacher RE. Clinical, biological and biochemical effects of pyrazofurin Cancer Research. 38: 682-688. PMID 272228  0.042
1964 HANDSCHUMACHER RE. OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF Acta - Unio Internationalis Contra Cancrum. 20: 1051-1053. PMID 14274691  0.04
1963 Handschumacher RE, Škoda J, Šorm F. Metabolic and biochemical effects of 6-azacytidine in mice with Ehrlich ascites carcinoma Collection of Czechoslovak Chemical Communications. 28: 2983-2990. DOI: 10.1135/cccc19632983  0.039
1979 Schwartz PM, Handschumacher RE. Allopurinol (HPP)-5-fluorouracil (FU) antagonism: Biochemical mechanism and therapeutic exploitation Proceedings of the American Association For Cancer Research. 537.  0.038
1977 Jakubowski A, Lehman C, Moyer J, Handschumacher RE. Pyrazofurin: Nucleotide interconversions by adenosine kinase and nucleotide kinase Proceedings of the American Association For Cancer Research. No.865.  0.037
1995 Knott RB, Capel M, Hansen S, Handschumacher RE. A small-angle X-ray scattering study of the binding of cyclosporin A to cyclophilin Journal of Applied Crystallography. 28: 546-552. DOI: 10.1107/S0021889895003268  0.034
1974 Uren JR, Handschumacher RE. Evaluation of asparagine analogs as cancer chemotherapeutic agents Proceedings of the American Association For Cancer Research. No. 494.  0.033
1973 Chang PK, Sciarini LJ, Handschumacher RE. New asparagine analogs. Journal of Medicinal Chemistry. 16: 1277-80. PMID 4583884  0.032
1956 HANDSCHUMACHER RE, WELCH AD. Microbial studies of 6-azauracil, an antagonist of uracil. Cancer Research. 16: 965-9. PMID 13374706  0.027
1967 Felsenfeld H, Handschumacher RE. The interaction between lysozyme and penicillin Molecular Pharmacology. 3: 153-160. PMID 6034581  0.026
1962 VOLLE RL, GREEN RE, PETERS L, HANDSCHUMACHER RE, WELCH AD. Renal tubular excretion studies with pyrimidine derivatives and analogs. The Journal of Pharmacology and Experimental Therapeutics. 136: 353-360. PMID 13926634  0.025
1960 WELCH AD, HANDSCHUMACHER RE, FINCH SC, JAFFE JJ, CARDOSO SS, CALABRESI P. A synopsis of recent investigations of 6-azauridine (NSC-32074). Cancer Chemotherapy Reports. Part 1. 9: 39-46. PMID 13784172  0.025
1963 CREASEY WA, FINK ME, HANDSCHUMACHER RE, CALABRESI P. Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine Cancer Research. 23: 444-453. PMID 14023746  0.023
1962 HANDSCHUMACHER RE, CREASEY WA, FINK ME, CALABRESI P, WELCH AD. Pharmacological and clinical studies with triacetyl 6-azauridine. Cancer Chemotherapy Reports. Part 1. 16: 267-269. PMID 13904322  0.023
1988 Drugge RJ, Handschumacher RE. Cyclosporine--mechanism of action. Transplantation Proceedings. 20: 301-309. PMID 3284073  0.02
2010 Handschumacher RE, Vane JR. The relationship between the penetration of tryptamine and 5-hydroxytryptamine into smooth muscle and the associated contractions. British Journal of Pharmacology and Chemotherapy. 29: 105-18. PMID 19108234 DOI: 10.1111/j.1476-5381.1967.tb01944.x  0.015
1962 HANDSCHUMACHER RE, CALABRESI P, WELCH AD, BONO V, FALLON H, FREI E. Summary of current information on 6-azauridine. Cancer Chemotherapy Reports. Part 1. 21: 1-18. PMID 13904321  0.01
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