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Jonathan Flint - Publications

Affiliations: 
Psychiatry University of California, Los Angeles, Los Angeles, CA 
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chen PB, Chen R, LaPierre N, Chen Z, Mefford J, Marcus E, Heffel MG, Soto DC, Ernst J, Luo C, Flint J. Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior. Cell Genomics. 100545. PMID 38697120 DOI: 10.1016/j.xgen.2024.100545  0.59
2024 Chen PB, Chen R, LaPierre N, Chen Z, Mefford J, Marcus E, Heffel MG, Soto DC, Ernst J, Luo C, Flint J. Complementation testing identifies causal genes at quantitative trait loci underlying fear related behavior. Biorxiv : the Preprint Server For Biology. PMID 38260483 DOI: 10.1101/2024.01.03.574060  0.592
2023 Flint J, Heffel MG, Chen Z, Mefford J, Marcus E, Chen PB, Ernst J, Luo C. Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription. Cell Genomics. 3: 100454. PMID 38116123 DOI: 10.1016/j.xgen.2023.100454  0.528
2023 An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S. Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries. Nature Genetics. PMID 37985819 DOI: 10.1038/s41588-023-01558-w  0.358
2023 Cui L, Yang B, Xiao S, Gao J, Baud A, Graham D, McBride M, Dominiczak A, Schafer S, Aumatell RL, Mont C, Teruel AF, Hübner N, Flint J, Mott R, et al. Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biology. 24: 215. PMID 37773188 DOI: 10.1186/s13059-023-03060-2  0.375
2023 Flint J. The genetic basis of major depressive disorder. Molecular Psychiatry. PMID 36702864 DOI: 10.1038/s41380-023-01957-9  0.345
2021 Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J. Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility. G3 (Bethesda, Md.). PMID 34791208 DOI: 10.1093/g3journal/jkab394  0.347
2021 Chen PB, Flint J. What connectomics can learn from genomics. Plos Genetics. 17: e1009692. PMID 34270560 DOI: 10.1371/journal.pgen.1009692  0.49
2020 Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 32954640 DOI: 10.1002/Ajmg.B.32823  0.305
2020 Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, ... ... Flint J, et al. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nature Genetics. PMID 32231276 DOI: 10.1038/S41588-020-0594-5  0.312
2018 Lilue J, Doran AG, Fiddes IT, Abrudan M, Armstrong J, Bennett R, Chow W, Collins J, Collins S, Czechanski A, Danecek P, Diekhans M, Dolle DD, Dunn M, Durbin R, ... ... Flint J, et al. Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nature Genetics. PMID 30275530 DOI: 10.1038/S41588-018-0223-8  0.322
2017 Baud A, Flint J. Identifying genes for neurobehavioural traits in rodents: progress and pitfalls. Disease Models & Mechanisms. 10: 373-383. PMID 28381599 DOI: 10.1242/dmm.027789  0.357
2016 Peterson RE, Cai N, Bigdeli TB, Li Y, Reimers M, Nikulova A, Webb BT, Bacanu SA, Riley BP, Flint J, Kendler KS. The Genetic Architecture of Major Depressive Disorder in Han Chinese Women. Jama Psychiatry. PMID 28002544 DOI: 10.1001/Jamapsychiatry.2016.3578  0.303
2016 Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, ... ... Flint J, et al. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nature Genetics. PMID 27376238 DOI: 10.1038/Ng.3595  0.32
2016 McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda, Md.). PMID 27233670 DOI: 10.1534/G3.116.030767  0.324
2016 Gage SH, Davey Smith G, Ware JJ, Flint J, Munafò MR. G = E: What GWAS Can Tell Us about the Environment. Plos Genetics. 12: e1005765. PMID 26866486 DOI: 10.1371/journal.pgen.1005765  0.318
2015 Geschwind DH, Flint J. Genetics and genomics of psychiatric disease. Science (New York, N.Y.). 349: 1489-94. PMID 26404826 DOI: 10.1126/science.aaa8954  0.314
2014 Baud A, Guryev V, Hummel O, Johannesson M, Flint J. Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data. 1: 140011. PMID 25977769 DOI: 10.1038/sdata.2014.11  0.311
2014 Munafò MR, Flint J. The genetic architecture of psychophysiological phenotypes Psychophysiology. 51: 1331-1332. PMID 25387716 DOI: 10.1111/psyp.12355  0.344
2014 Flint J, Timpson N, Munafò M. Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease Trends in Neurosciences. 37: 733-741. PMID 25216981 DOI: 10.1016/j.tins.2014.08.007  0.337
2014 Krohn J, Speed D, Palme R, Touma C, Mott R, Flint J. Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice. Plos One. 9: e96450. PMID 24811081 DOI: 10.1371/Journal.Pone.0096450  0.361
2014 Flint J, Kendler KS. The genetics of major depression. Neuron. 81: 484-503. PMID 24507187 DOI: 10.1016/j.neuron.2014.01.027  0.313
2013 White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, ... ... Flint J, et al. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 154: 452-64. PMID 23870131 DOI: 10.1016/J.Cell.2013.06.022  0.325
2013 Baud A, Calderari S, Mott R, Flint J, Gauguier D. [Genome sequencing and genetic mapping to dissect the genetic basis of complex traits]. MéDecine Sciences : M/S. 29: 671-4. PMID 23859526 DOI: 10.1051/Medsci/2013296024  0.367
2013 Mott R, Flint J. Dissecting quantitative traits in mice. Annual Review of Genomics and Human Genetics. 14: 421-39. PMID 23834320 DOI: 10.1146/Annurev-Genom-091212-153419  0.323
2013 Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, ... ... Flint J, et al. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics. 45: 767-75. PMID 23708188 DOI: 10.1038/Ng.2644  0.366
2013 Flint J, Munafò MR. Candidate and non-candidate genes in behavior genetics Current Opinion in Neurobiology. 23: 57-61. PMID 22878161 DOI: 10.1016/j.conb.2012.07.005  0.41
2012 Yalcin B, Flint J. Association studies in outbred mice in a new era of full-genome sequencing. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 719-26. PMID 22847376 DOI: 10.1007/s00335-012-9409-z  0.324
2012 Nellåker C, Keane TM, Yalcin B, Wong K, Agam A, Belgard TG, Flint J, Adams DJ, Frankel WN, Ponting CP. The genomic landscape shaped by selection on transposable elements across 18 mouse strains. Genome Biology. 13: R45. PMID 22703977 DOI: 10.1186/Gb-2012-13-6-R45  0.339
2011 Yalcin B, Wong K, Agam A, Goodson M, Keane TM, Gan X, Nellåker C, Goodstadt L, Nicod J, Bhomra A, Hernandez-Pliego P, Whitley H, Cleak J, Dutton R, Janowitz D, ... ... Flint J, et al. Sequence-based characterization of structural variation in the mouse genome. Nature. 477: 326-9. PMID 21921916 DOI: 10.1038/Nature10432  0.381
2011 Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, NellÃ¥ker C, Whitley H, Cleak J, ... ... Flint J, et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature. 477: 289-94. PMID 21921910 DOI: 10.1038/Nature10413  0.369
2011 Hettema JM, Webb BT, Guo AY, Zhao Z, Maher BS, Chen X, An SS, Sun C, Aggen SH, Kendler KS, Kuo PH, Otowa T, Flint J, van den Oord EJ. Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders. Biological Psychiatry. 70: 888-96. PMID 21871609 DOI: 10.1016/J.Biopsych.2011.07.012  0.308
2011 Munafò MR, Flint J. Dissecting the genetic architecture of human personality. Trends in Cognitive Sciences. 15: 395-400. PMID 21831694 DOI: 10.1016/j.tics.2011.07.007  0.336
2011 Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis and Rheumatism. 63: 2630-40. PMID 21560115 DOI: 10.1002/Art.30425  0.315
2010 Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, ØsterÃ¥s M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, ... ... Flint J, et al. Commercially available outbred mice for genome-wide association studies. Plos Genetics. 6: e1001085. PMID 20838427 DOI: 10.1371/Journal.Pgen.1001085  0.337
2009 Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW. A new standard genetic map for the laboratory mouse. Genetics. 182: 1335-44. PMID 19535546 DOI: 10.1534/Genetics.109.105486  0.313
2009 Flint J, Mackay TF. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Research. 19: 723-33. PMID 19411597 DOI: 10.1101/gr.086660.108  0.401
2009 Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research. 19: 1133-40. PMID 19376938 DOI: 10.1101/Gr.088120.108  0.313
2009 Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, ... ... Flint J, et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Research. 19: 150-8. PMID 18971309 DOI: 10.1101/Gr.081497.108  0.302
2008 Mott R, Flint J. Prospects for complex trait analysis in the mouse. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 306-8. PMID 18493822 DOI: 10.1007/S00335-008-9110-4  0.312
2008 Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J. Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. Biological Psychiatry. 63: 874-83. PMID 18083140 DOI: 10.1016/J.Biopsych.2007.10.019  0.305
2006 Flint J, Munafò MR. The endophenotype concept in psychiatric genetics. Psychological Medicine. 37: 163-80. PMID 16978446 DOI: 10.1017/S0033291706008750  0.319
2006 Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nature Genetics. 38: 879-87. PMID 16832355 DOI: 10.1038/Ng1840  0.354
2006 Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, ... ... Flint J, et al. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 439: 851-5. PMID 16482158 DOI: 10.1038/nature04489  0.316
2004 Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nature Genetics. 36: 1197-202. PMID 15489855 DOI: 10.1038/Ng1450  0.341
2004 Flint J. The genetic basis of neuroticism Neuroscience and Biobehavioral Reviews. 28: 307-316. PMID 15225973 DOI: 10.1016/j.neubiorev.2004.01.004  0.326
2004 Turri MG, DeFries JC, Henderson ND, Flint J. Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 69-76. PMID 15058378 DOI: 10.1007/S00335-003-3032-Y  0.332
2003 Talbot CJ, Radcliffe RA, Fullerton J, Hitzemann R, Wehner JM, Flint J. Fine scale mapping of a genetic locus for conditioned fear. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 223-30. PMID 12682774 DOI: 10.1007/S00335-002-3059-5  0.31
2003 Steinberger D, Reynolds DS, Ferris P, Lincoln R, Datta S, Stanley J, Paterson A, Dawson GR, Flint J. Genetic mapping of variation in spatial learning in the mouse Journal of Neuroscience. 23: 2426-2433. PMID 12657702  0.321
2003 Flint J. Analysis of quantitative trait loci that influence animal behavior Journal of Neurobiology. 54: 46-77. PMID 12486698 DOI: 10.1002/neu.10161  0.407
2002 Fernández-Teruel A, Escorihuela RM, Gray JA, Aguilar R, Gil L, Giménez-Llort L, Tobeña A, Bhomra A, Nicod A, Mott R, Driscoll P, Dawson GR, Flint J. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Research. 12: 618-26. PMID 11932246 DOI: 10.1101/Gr.203402  0.346
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