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Jon Tryggvi Njardarson - Publications

Affiliations: 
2004-2010 Chemistry and Chemical Biology Cornell University, Ithaca, NY, United States 
 2010- University of Arizona, Tucson, AZ 
Website:
http://cbc.arizona.edu/faculty/jon-njardarson
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78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bao J, Nick SJ, Lanin AS, Iragorri Molinero N, Sera BJ, Njardarson JT. Stereoselective Synthesis of Conjugated Di- and Trienamides via a Dienolate Enabled Anionic Cascade. The Journal of Organic Chemistry. PMID 38048698 DOI: 10.1021/acs.joc.3c02327  0.417
2023 Groch JR, Lauta NR, Njardarson JT. One Step Selective Counterion Dependent Formation of Conjugated Chiral N-Sulfinylimines from Aldehydes. Organic Letters. 25: 395-399. PMID 36603180 DOI: 10.1021/acs.orglett.2c04102  0.376
2022 Qureshi MH, Njardarson JT. Anionic Amino-Cope Rearrangement Cascade Synthesis of 2,4-Substituted Benzoate Esters from Acyclic Building Blocks. Organic Letters. 24: 7978-7982. PMID 36268999 DOI: 10.1021/acs.orglett.2c03134  0.345
2021 Delost MD, Njardarson JT. Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF) Aziridine and Cyclopropane Structures. Organic Letters. 23: 6121-6125. PMID 34292753 DOI: 10.1021/acs.orglett.1c02204  0.419
2021 Scott KA, Groch JR, Chogii I, Delost MD, Das P, Njardarson JT. Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures. The Journal of Organic Chemistry. PMID 34283591 DOI: 10.1021/acs.joc.1c01211  0.42
2021 Scott KA, Groch JR, Chogii I, Delost MD, Das P, Njardarson JT. Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures. The Journal of Organic Chemistry. PMID 34283591 DOI: 10.1021/acs.joc.1c01211  0.42
2021 Lauta NR, Williams RE, Smith DT, Kumirov VK, Njardarson JT. Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of -Allenyl Anilines. The Journal of Organic Chemistry. PMID 34282910 DOI: 10.1021/acs.joc.1c01379  0.342
2021 Das P, Delost MD, Qureshi MH, Bao J, Fell JS, Houk KN, Njardarson JT. Dramatic Effect of γ-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades. Journal of the American Chemical Society. PMID 33844522 DOI: 10.1021/jacs.1c00745  0.347
2020 Delost MD, Njardarson JT. Strategic Vinyl Sulfone Nucleophile β-Substitution Significantly Impacts Selectivity in Vinylogous Darzens and Aza-Darzens Reactions. Organic Letters. PMID 32822201 DOI: 10.1021/Acs.Orglett.0C02448  0.384
2019 Chogii I, Das P, Njardarson JT. Efforts Toward a Unified Kainoid Family Synthesis Approach: Unexpected Sulfinamide‐Directed Conjugate Addition Results Asian Journal of Organic Chemistry. 8: 1041-1044. DOI: 10.1002/Ajoc.201800728  0.409
2018 Chogii I, Das P, Delost MD, Crawford MN, Njardarson JT. Asymmetric Vinylogous Aza-Darzens Approach to Vinyl Aziridines. Organic Letters. PMID 30052042 DOI: 10.1021/Acs.Orglett.8B02074  0.483
2018 Delost MD, Smith DT, Anderson BJ, Njardarson JT. From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles. Journal of Medicinal Chemistry. PMID 30024747 DOI: 10.1021/Acs.Jmedchem.8B00876  0.305
2018 Chogii I, Das P, Fell JS, Scott KA, Crawford MN, Houk KN, Njardarson JT. Correction to "New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures". Journal of the American Chemical Society. PMID 30010325 DOI: 10.1021/Jacs.8B06895  0.307
2018 Smith BR, Njardarson JT. Correction to [2.2.2]- to [3.2.1]-Bicycle Skeletal Rearrangement Approach to the Gibberellin Family of Natural Products. Organic Letters. PMID 30004713 DOI: 10.1021/Acs.Orglett.8B02053  0.36
2018 Smith BR, Njardarson JT. Review of synthetic approaches toward maoecrystal V. Organic & Biomolecular Chemistry. PMID 29775191 DOI: 10.1039/C8Ob00909K  0.338
2018 Smith BR, Njardarson JT. [2.2.2]- to [3.2.1]-Bicycle Skeletal Rearrangement Approach to the Gibberellin Family of Natural Products. Organic Letters. PMID 29722990 DOI: 10.1021/Acs.Orglett.8B01031  0.448
2017 Leung JC, Bedermann AA, Njardarson JT, Spiegel DA, Murphy GK, Hama N, Twenter BM, Dong P, Shirahata T, McDonald IM, Inoue M, Taniguchi N, McMahon TC, Schneider CM, Tao N, et al. Total Synthesis of (±)-Phomoidride D. Angewandte Chemie (International Ed. in English). PMID 29286556 DOI: 10.1002/Anie.201712369  0.768
2017 Smith BR, Njardarson JT. Double-Diels-Alder Approach to Maoecrystal V. Unexpected C-C Bond-Forming Fragmentations of the [2.2.2]-Bicyclic Core. Organic Letters. PMID 28910114 DOI: 10.1021/Acs.Orglett.7B02606  0.406
2017 Chogii I, Das P, Fell JS, Scott KA, Crawford MN, Houk KN, Njardarson JT. New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures. Journal of the American Chemical Society. PMID 28885835 DOI: 10.1021/Jacs.7B07319  0.411
2017 Smith DT, Vitaku E, Njardarson JT. Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products. Organic Letters. PMID 28598632 DOI: 10.1021/Acs.Orglett.7B01479  0.426
2016 Vitaku E, Smith DT, Njardarson JT. Metal-Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization. Angewandte Chemie (International Ed. in English). PMID 26748561 DOI: 10.1002/Anie.201511149  0.469
2016 Vitaku E, Njardarson JT. A Mildmeta-Selective C-H Alkylation of Catechol Mono-Ethers European Journal of Organic Chemistry. 2016: 3679-3683. DOI: 10.1002/Ejoc.201600760  0.374
2016 Das P, Njardarson JT. Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio- and Aminophosphate Precursors European Journal of Organic Chemistry. 2016: 4249-4259. DOI: 10.1002/Ejoc.201600312  0.406
2015 Chogii I, Njardarson JT. Asymmetric [3+2] Annulation Approach to 3-Pyrrolines: Concise Total Syntheses of (-)-Supinidine, (-)-Isoretronecanol, and (+)-Elacomine. Angewandte Chemie (International Ed. in English). 54: 13706-10. PMID 26447827 DOI: 10.1002/Anie.201506559  0.519
2015 Das P, Njardarson JT. Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches. Organic Letters. 17: 4030-3. PMID 26247299 DOI: 10.1021/Acs.Orglett.5B01937  0.441
2015 Vitaku E, Njardarson JT. Formation of Fused Aromatic Architectures via an Oxidative Dearomatization - Radical Cyclization Rearomatization Approach. Tetrahedron Letters. 56: 3550-3552. PMID 26236054 DOI: 10.1016/J.Tetlet.2015.01.110  0.456
2015 Draghici C, Njardarson JT. Synthetic Approaches and Total Syntheses of Vinigrol, a Unique Diterpenoid. Tetrahedron. 71: 3775-3793. PMID 26034329 DOI: 10.1016/J.Tet.2015.04.073  0.393
2015 Draghici C, Njardarson JT. The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol Strategies and Tactics in Organic Synthesis. 11: 335-376. DOI: 10.1016/B978-0-08-100023-6.00011-7  0.447
2014 Vitaku E, Smith DT, Njardarson JT. Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. Journal of Medicinal Chemistry. 57: 10257-74. PMID 25255204 DOI: 10.1021/Jm501100B  0.353
2014 Smith DT, Njardarson JT. A scalable rhodium-catalyzed intermolecular aziridination reaction. Angewandte Chemie (International Ed. in English). 53: 4278-80. PMID 24596144 DOI: 10.1002/Anie.201400502  0.328
2014 Yang Q, Draghici C, Njardarson JT, Li F, Smith BR, Das P. Evolution of an oxidative dearomatization enabled total synthesis of vinigrol. Organic & Biomolecular Chemistry. 12: 330-44. PMID 24258093 DOI: 10.1039/C3Ob42191K  0.5
2014 Guo B, Vitaku E, Njardarson JT. Mild stereoselective formation of tri- and tetrasubstituted olefins by regioselective ring opening of 1,1-disubstituted vinyl oxiranes with dialkyl dithiophosphates Tetrahedron Letters. 55: 3232-3234. DOI: 10.1016/J.Tetlet.2014.04.028  0.478
2013 Yang Q, Njardarson JT. Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group. Tetrahedron Letters. 54. PMID 24391289 DOI: 10.1016/J.Tetlet.2013.10.097  0.442
2013 Guo B, Njardarson JT. Z-Selective ring opening of vinyl oxetanes with dialkyl dithiophosphate nucleophiles. Chemical Communications (Cambridge, England). 49: 10802-4. PMID 24121797 DOI: 10.1039/C3Cc46660D  0.445
2013 Ilardi EA, Njardarson JT. Ring expansions of vinyloxiranes, -thiiranes, and -aziridines: synthetic approaches, challenges, and catalytic success stories. The Journal of Organic Chemistry. 78: 9533-40. PMID 24024961 DOI: 10.1021/Jo401776S  0.474
2013 Yang Q, Njardarson JT, Draghici C, Li F. Total synthesis of vinigrol. Angewandte Chemie (International Ed. in English). 52: 8648-51. PMID 23818094 DOI: 10.1002/Anie.201304624  0.455
2013 Mack DJ, Njardarson JT. Syntheses and structural confirmations of members of a heterocycle-containing family of labdane diterpenoids. Angewandte Chemie (International Ed. in English). 52: 1543-7. PMID 23255166 DOI: 10.1002/Anie.201208412  0.448
2013 Njardarson JT. Catalytic ring expansion adventures Synlett. 24: 787-803. DOI: 10.1055/S-0032-1318326  0.469
2013 MacK DJ, Njardarson JT. Recent advances in the metal-catalyzed ring expansions of three- and four-membered rings Acs Catalysis. 3: 272-286. DOI: 10.1021/Cs300771D  0.454
2012 Mack DJ, Isoe J, Miesfeld RL, Njardarson JT. Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes. Bioorganic & Medicinal Chemistry Letters. 22: 5177-81. PMID 22818079 DOI: 10.1016/J.Bmcl.2012.06.076  0.32
2012 Mack DJ, Guo B, Njardarson JT. Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C-O reduction approach. Chemical Communications (Cambridge, England). 48: 7844-6. PMID 22751476 DOI: 10.1039/C2Cc33551D  0.369
2012 Guo B, Schwarzwalder G, Njardarson JT. Catalytic ring expansion of vinyl oxetanes: asymmetric synthesis of dihydropyrans using chiral counterion catalysis. Angewandte Chemie (International Ed. in English). 51: 5675-8. PMID 22528273 DOI: 10.1002/Anie.201201367  0.491
2012 Li F, Calabrese D, Brichacek M, Lin I, Njardarson JT. Efficient synthesis of thiopyrans using a sulfur-enabled anionic cascade. Angewandte Chemie (International Ed. in English). 51: 1938-41. PMID 22234934 DOI: 10.1002/Anie.201108261  0.792
2012 Mack DJ, Batory LA, Njardarson JT. Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles. Organic Letters. 14: 378-81. PMID 22188418 DOI: 10.1021/Ol203129D  0.818
2012 MacK DJ, Njardarson JT. New mechanistic insights into the copper catalyzed ring expansion of vinyl aziridines: Evidence in support of a copper(i) mediated pathway Chemical Science. 3: 3321-3325. DOI: 10.1039/C2Sc21007J  0.401
2012 Njardarson JT. Reactions at your fingertips Nature Chemistry. 4: 590-590. DOI: 10.1038/Nchem.1416  0.309
2012 Draghici C, Njardarson JT. Chemistry by design: A web-based educational flashcard for exploring synthetic organic chemistry Journal of Chemical Education. 89: 1080-1082. DOI: 10.1021/Ed2006423  0.308
2011 Njardarson JT. Synthetic Efforts Toward [3.3.1] Bridged Bicyclic Phloroglucinol Natural Products. Tetrahedron. 67: 7631-7666. PMID 23172980 DOI: 10.1016/J.Tet.2011.06.079  0.378
2011 Lecomte N, Njardarson JT, Nagorny P, Yang G, Downey R, Ouerfelli O, Moore MA, Danishefsky SJ. Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proceedings of the National Academy of Sciences of the United States of America. 108: 15074-8. PMID 21808037 DOI: 10.1073/Pnas.1015247108  0.667
2011 Brichacek M, Villalobos MN, Plichta A, Njardarson JT. Stereospecific ring expansion of chiral vinyl aziridines. Organic Letters. 13: 1110-3. PMID 21309528 DOI: 10.1021/Ol200263G  0.801
2011 McGrath NA, Binner JR, Markopoulos G, Brichacek M, Njardarson JT. An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products. Chemical Communications (Cambridge, England). 47: 209-11. PMID 20607196 DOI: 10.1039/C0Cc01419B  0.802
2010 Nagorny P, Krauss I, Njardarson JT, Perez L, Gaul C, Yang G, Ouerfelli O, Danishefsky SJ. Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims. Tetrahedron Letters. 51: 3873-3875. PMID 20676392 DOI: 10.1016/J.Tetlet.2010.05.056  0.759
2010 Brichacek M, Batory LA, Njardarson JT. Stereoselective ring expansion of vinyl oxiranes: mechanistic insights and natural product total synthesis. Angewandte Chemie (International Ed. in English). 49: 1648-51. PMID 20135664 DOI: 10.1002/Anie.200906830  0.796
2010 McGrath NA, Brichacek M, Njardarson JT. A graphical journey of innovative organic architectures that have improved our lives Journal of Chemical Education. 87: 1348-1349. DOI: 10.1021/Ed1003806  0.737
2010 Brichacek M, Batory LA, McGrath NA, Njardarson JT. The strategic marriage of method and motif. Total synthesis of varitriol Tetrahedron. 66: 4832-4840. DOI: 10.1016/J.Tet.2010.03.038  0.78
2009 McGrath NA, Bartlett ES, Sittihan S, Njardarson JT. A concise ring-expansion route to the compact core of platensimycin. Angewandte Chemie (International Ed. in English). 48: 8543-6. PMID 19798708 DOI: 10.1002/Anie.200903347  0.799
2009 Morton JG, Draghici C, Kwon LD, Njardarson JT. Rapid assembly of vinigrol's unique carbocyclic skeleton. Organic Letters. 11: 4492-5. PMID 19728692 DOI: 10.1021/Ol901519K  0.779
2009 Brichacek M, Njardarson JT. Creative approaches towards the synthesis of 2,5-dihydro- furans, thiophenes, and pyrroles. One method does not fit all! Organic & Biomolecular Chemistry. 7: 1761-70. PMID 19590767 DOI: 10.1039/B900236G  0.771
2009 Morton JGM, Kwon LD, Freeman JD, Njardarson JT. Thieme Chemistry Journal awardees - Where are they now? Efforts towards the total synthesis of vinigrol Synlett. 23-27. DOI: 10.1055/S-0028-1087378  0.508
2009 Morton JGM, Kwon LD, Freeman JD, Njardarson JT. An Adler-Becker oxidation approach to vinigrol Tetrahedron Letters. 50: 1684-1686. DOI: 10.1016/J.Tetlet.2009.01.134  0.371
2008 McGrath NA, Lee CA, Araki H, Brichacek M, Njardarson JT. An efficient substrate-controlled approach towards hypoestoxide, a member of a family of diterpenoid natural products with an inside-out [9.3.1]bicyclic core. Angewandte Chemie (International Ed. in English). 47: 9450-3. PMID 18979485 DOI: 10.1002/Anie.200804237  0.773
2008 Brichacek M, Lee D, Njardarson JT. Lewis acid catalyzed [1,3]-sigmatropic rearrangement of vinyl aziridines. Organic Letters. 10: 5023-6. PMID 18841992 DOI: 10.1021/Ol802123E  0.765
2007 Rogers E, Araki H, Batory LA, McInnis CE, Njardarson JT. Highly selective copper-catalyzed ring expansion of vinyl thiiranes: application to synthesis of biotin and the heterocyclic core of plavix. Journal of the American Chemical Society. 129: 2768-9. PMID 17302422 DOI: 10.1021/Ja069059H  0.82
2006 Batory LA, McInnis CE, Njardarson JT. Copper-catalyzed rearrangement of vinyl oxiranes. Journal of the American Chemical Society. 128: 16054-5. PMID 17165756 DOI: 10.1021/Ja067073O  0.783
2005 Shan D, Chen L, Njardarson JT, Gaul C, Ma X, Danishefsky SJ, Huang XY. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 3772-6. PMID 15728385 DOI: 10.1073/Pnas.0500658102  0.425
2004 Gaul C, Njardarson JT, Shan D, Dorn DC, Wu KD, Tong WP, Huang XY, Moore MA, Danishefsky SJ. The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. Journal of the American Chemical Society. 126: 11326-37. PMID 15355116 DOI: 10.1021/Ja048779Q  0.611
2004 Njardarson JT, Gaul C, Shan D, Huang XY, Danishefsky SJ. Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. Journal of the American Chemical Society. 126: 1038-40. PMID 14746469 DOI: 10.1021/Ja039714A  0.518
2003 Spiegel DA, Njardarson JT, McDonald IM, Wood JL. The art of innovation in organic chemistry: synthetic efforts toward the phomoidrides. Chemical Reviews. 103: 2691-727. PMID 12848583 DOI: 10.1021/Cr020408+  0.705
2003 Gaul C, Njardarson JT, Danishefsky SJ. The total synthesis of (+)-migrastatin. Journal of the American Chemical Society. 125: 6042-3. PMID 12785819 DOI: 10.1021/Ja0349103  0.647
2003 Wood JL, Graeber JK, Njardarson JT. Application of phenolic oxidation chemistry in synthesis: Preparation of the BCE ring system of ryanodine Tetrahedron. 59: 8855-8858. DOI: 10.1016/J.Tet.2003.05.001  0.75
2002 Njardarson JT, Biswas K, Danishefsky SJ. Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis. Chemical Communications (Cambridge, England). 2759-61. PMID 12478733 DOI: 10.1039/B209941A  0.615
2002 Rivkin A, Njardarson JT, Biswas K, Chou TC, Danishefsky SJ. Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. The Journal of Organic Chemistry. 67: 7737-40. PMID 12398497 DOI: 10.1021/Jo0204294  0.543
2002 Biswas K, Lin H, Njardarson JT, Chappell MD, Chou TC, Guan Y, Tong WP, He L, Horwitz SB, Danishefsky SJ. Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490. Journal of the American Chemical Society. 124: 9825-32. PMID 12175242 DOI: 10.1021/Ja0262333  0.617
2002 Drutu I, Njardarson JT, Wood JL. Reactive dienes: intramolecular aromatic oxidation of 3-(2-hydroxyphenyl)-propionic acids. Organic Letters. 4: 493-6. PMID 11843574 DOI: 10.1021/Ol0169776  0.774
2002 Spiegel DA, Njardarson JT, Wood JL. CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion Tetrahedron. 58: 6545-6554. DOI: 10.1016/S0040-4020(02)00664-6  0.666
2001 Njardarson JT, McDonald IM, Spiegel DA, Inoue M, Wood JL. An expeditious approach toward the total synthesis of CP-263,114. Organic Letters. 3: 2435-8. PMID 11483028 DOI: 10.1021/Ol015979N  0.793
2001 Njardarson JT, Wood JL. Evolution of a synthetic approach to CP-263,114. Organic Letters. 3: 2431-4. PMID 11483027 DOI: 10.1021/Ol015978V  0.528
1994 Geirsson JKF, Njardarson JT. A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions Tetrahedron Letters. 35: 9071-9072. DOI: 10.1016/0040-4039(94)88430-7  0.342
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