| Year |
Citation |
Score |
| 2023 |
Sun X, Alfermann J, Li H, Watkins MB, Chen YT, Morrell TE, Mayerthaler F, Wang CY, Komatsuzaki T, Chu JW, Ando N, Mootz HD, Yang H. Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases. Nature Chemistry. PMID 38049653 DOI: 10.1038/s41557-023-01361-4 |
0.352 |
|
| 2023 |
Pasch T, Schröder A, Kattelmann S, Eisenstein M, Pietrokovski S, Kümmel D, Mootz HD. Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins. Chemical Science. 14: 5204-5213. PMID 37206380 DOI: 10.1039/d3sc01200j |
0.376 |
|
| 2023 |
Diecker J, Dörner W, Rüschenbaum J, Mootz HD. Unraveling Structural Information of Multi-Domain Nonribosomal Peptide Synthetases by Using Photo-Cross-Linking Analysis with Genetic Code Expansion. Methods in Molecular Biology (Clifton, N.J.). 2670: 165-185. PMID 37184704 DOI: 10.1007/978-1-0716-3214-7_8 |
0.41 |
|
| 2022 |
Rüschenbaum J, Steinchen W, Mayerthaler F, Feldberg AL, Mootz HD. FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling Between Catalytic Domains. Angewandte Chemie (International Ed. in English). PMID 36169151 DOI: 10.1002/anie.202212994 |
0.389 |
|
| 2022 |
Jedlitzke B, Mootz HD. A Light-Activatable Photocaged Variant of the Ultra-High Affinity ALFA-Tag Nanobody. Chembiochem : a European Journal of Chemical Biology. e202200079. PMID 35411584 DOI: 10.1002/cbic.202200079 |
0.343 |
|
| 2022 |
Palei S, Jose J, Mootz HD. Preparation of Bacterial Cell-Surface Displayed Semisynthetic Cyclic Peptides. Methods in Molecular Biology (Clifton, N.J.). 2371: 193-213. PMID 34596850 DOI: 10.1007/978-1-0716-1689-5_11 |
0.808 |
|
| 2021 |
Mayerthaler F, Feldberg AL, Alfermann J, Sun X, Steinchen W, Yang H, Mootz HD. Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases. Rsc Chemical Biology. 2: 843-854. PMID 34458813 DOI: 10.1039/d0cb00220h |
0.341 |
|
| 2021 |
Palei S, Mootz HD. Semisynthetic head-to-tail cyclized peptides obtained by combining protein -splicing and intramolecular expressed protein ligation. Chemical Communications (Cambridge, England). 57: 4194-4197. PMID 33908454 DOI: 10.1039/d1cc00449b |
0.818 |
|
| 2021 |
Reille-Seroussi M, Meyer-Ahrens P, Aust A, Feldberg AL, Mootz HD. Genetic encoding and enzymatic deprotection of a latent thiol side chain to enable new protein bioconjugation applications. Angewandte Chemie (International Ed. in English). PMID 33844389 DOI: 10.1002/anie.202102343 |
0.326 |
|
| 2020 |
Hoffmann S, Terhorst TME, Singh RK, Kümmel D, Pietrokovski S, Mootz HD. Biochemical and structural characterization of an unusual and naturally split class 3 intein. Chembiochem : a European Journal of Chemical Biology. PMID 32813312 DOI: 10.1002/Cbic.202000509 |
0.419 |
|
| 2020 |
Brüninghoff K, Aust A, Taupitz KF, Wulff S, Dörner W, Mootz HD. Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking. Acs Chemical Biology. PMID 32786267 DOI: 10.1021/Acschembio.0C00609 |
0.407 |
|
| 2020 |
Bhagawati M, Hoffmann S, Höffgen KS, Piehler J, Busch KB, Mootz HD. In Cellulo Protein Semi-Synthesis from Endogenous and Exogenous Fragments Using the Ultra-Fast Split Gp41-1 Intein. Angewandte Chemie (International Ed. in English). PMID 32777124 DOI: 10.1002/Anie.202006822 |
0.485 |
|
| 2020 |
Dehling E, Rüschenbaum J, Diecker J, Dörner W, Mootz HD. Photo-crosslink analysis in nonribosomal peptide synthetases reveals aberrant gel migration of branched crosslink isomers and spatial proximity between non-neighboring domains Chemical Science. 11: 8945-8954. DOI: 10.1039/D0Sc01969K |
0.41 |
|
| 2019 |
Mootz HD, Jedlitzke B, Yilmaz Z, Dörner W. Photobodies: Light-activatable single-domain antibody fragments. Angewandte Chemie (International Ed. in English). PMID 31755215 DOI: 10.1002/Anie.201912286 |
0.339 |
|
| 2019 |
Bhagawati M, Terhorst TME, Füsser F, Hoffmann S, Pasch T, Pietrokovski S, Mootz HD. A mesophilic cysteine-less split intein for protein -splicing applications under oxidizing conditions. Proceedings of the National Academy of Sciences of the United States of America. 116: 22164-22172. PMID 31611397 DOI: 10.1073/Pnas.1909825116 |
0.556 |
|
| 2019 |
Kotter A, Mootz HD, Heuer A. Standard binding free energy of a SIM SUMO complex. Journal of Chemical Theory and Computation. PMID 31525924 DOI: 10.1021/Acs.Jctc.9B00428 |
0.406 |
|
| 2019 |
Reille-Seroussi M, Mayer SV, Dörner W, Lang K, Mootz HD. Expanding the genetic code with a lysine derivative bearing an enzymatically removable phenylacetyl group. Chemical Communications (Cambridge, England). PMID 30945708 DOI: 10.1039/C9Cc00475K |
0.438 |
|
| 2019 |
Degen A, Mayerthaler F, Mootz HD, Di Ventura B. Context-dependent activity of A domains in the tyrocidine synthetase. Scientific Reports. 9: 5119. PMID 30914767 DOI: 10.1038/S41598-019-41492-8 |
0.408 |
|
| 2019 |
Friedel K, Popp MA, Matern JCJ, Gazdag EM, Thiel IV, Volkmann G, Blankenfeldt W, Mootz HD. A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine. Chemical Science. 10: 239-251. PMID 30713635 DOI: 10.2210/Pdb6Frg/Pdb |
0.436 |
|
| 2019 |
Böcker JK, Dörner W, Mootz HD. Light-control of the ultra-fast Gp41-1 split intein with preserved stability of a genetically encoded photo-caged amino acid in bacterial cells. Chemical Communications (Cambridge, England). 55: 1287-1290. PMID 30633261 DOI: 10.1039/C8Cc09204D |
0.415 |
|
| 2018 |
Böcker JK, Dörner W, Mootz HD. Rational Design of an Improved Photo-Activatable Intein for the Production of Head-To-Tail Cyclized Peptides. Biological Chemistry. PMID 30403651 DOI: 10.1515/Hsz-2018-0367 |
0.591 |
|
| 2018 |
Hagmann V, Sommer S, Fabian P, Bierlmeier J, van Treel N, Mootz HD, Schwarzer D, Azevedo JE, Dodt G. Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery. Scientific Reports. 8: 16014. PMID 30375424 DOI: 10.1038/S41598-018-34200-5 |
0.354 |
|
| 2018 |
Di Ventura B, Mootz HD. Switchable inteins for conditional protein splicing. Biological Chemistry. PMID 30226200 DOI: 10.1515/Hsz-2018-0309 |
0.403 |
|
| 2018 |
Palei S, Becher KS, Nienberg C, Jose J, Mootz HD. Bacterial Cell Surface Display of Semi-Synthetic Cyclic Peptides. Chembiochem : a European Journal of Chemical Biology. PMID 30216604 DOI: 10.1002/Cbic.201800552 |
0.816 |
|
| 2018 |
Matern JCJ, Friedel K, Binschik J, Becher KS, Yilmaz Z, Mootz HD. Altered Coordination of Individual Catalytic Steps in Different and Evolved Inteins Reveals Kinetic Plasticity of the Protein Splicing Pathway. Journal of the American Chemical Society. PMID 30111090 DOI: 10.1021/Jacs.8B04794 |
0.374 |
|
| 2018 |
Pirzer T, Becher KS, Rieker M, Meckel T, Mootz HD, Kolmar H. Generation of potent anti-HER1/2 immunotoxins by protein ligation using split inteins. Acs Chemical Biology. PMID 29920062 DOI: 10.1021/Acschembio.8B00222 |
0.372 |
|
| 2018 |
Palei S, Becher KS, Nienberg C, Jose J, Mootz HD. Cover Feature: Bacterial Cell‐Surface Display of Semisynthetic Cyclic Peptides (ChemBioChem 1/2019) Chembiochem. 20: 4-4. DOI: 10.1002/Cbic.201800748 |
0.788 |
|
| 2017 |
Kost LJ, Mootz HD. A FRET sensor to monitor bivalent SUMO-SIM interactions in SUMO chain binding. Chembiochem : a European Journal of Chemical Biology. PMID 29120074 DOI: 10.1002/Cbic.201700507 |
0.336 |
|
| 2017 |
Alfermann J, Sun X, Mayerthaler F, Morrell TE, Dehling E, Volkmann G, Komatsuzaki T, Yang H, Mootz HD. FRET monitoring of a nonribosomal peptide synthetase. Nature Chemical Biology. PMID 28759017 DOI: 10.1038/Nchembio.2435 |
0.507 |
|
| 2017 |
Bachmann AL, Mootz HD. N-terminal chemical protein labeling using the naturally split GOS-TerL intein. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 28332258 DOI: 10.1002/Psc.2996 |
0.472 |
|
| 2017 |
Taupitz KF, Dörner W, Mootz HD. Covalent capturing of transient SUMO-SIM interactions using unnatural amino acid mutagenesis and photocrosslinking. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28121373 DOI: 10.1002/Chem.201605619 |
0.376 |
|
| 2017 |
Palei S, Mootz HD. Preparation of Semisynthetic Peptides Macrocycles Using Split Inteins. Methods in Molecular Biology (Clifton, N.J.). 1495: 77-92. PMID 27714611 DOI: 10.1007/978-1-4939-6451-2_6 |
0.822 |
|
| 2016 |
Dehling E, Volkmann G, Matern JC, Dörner W, Alfermann J, Diecker J, Mootz HD. Mapping of the communication-mediating interface in nonribosomal peptide synthetases using a genetically encoded photocrosslinker supports an upside-down helix-hand motif. Journal of Molecular Biology. PMID 27647046 DOI: 10.1016/J.Jmb.2016.09.007 |
0.472 |
|
| 2016 |
Neugebauer M, Böcker JK, Matern JC, Pietrokovski S, Mootz HD. Development of a screening system for inteins active in protein splicing based on intein insertion into the LacZα-peptide. Biological Chemistry. PMID 27632429 DOI: 10.1515/Hsz-2016-0229 |
0.541 |
|
| 2016 |
Nienberg C, Retterath A, Becher KS, Saenger T, Mootz HD, Jose J. Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications. Pharmaceuticals (Basel, Switzerland). 9. PMID 27355959 DOI: 10.3390/Ph9030036 |
0.386 |
|
| 2016 |
Palei S, Mootz HD. Cover Picture: Cyclic Peptides Made by Linking Synthetic and Genetically Encoded Fragments (ChemBioChem 5/2016) Chembiochem. 17: 352-352. DOI: 10.1002/Cbic.201600079 |
0.801 |
|
| 2015 |
Palei S, Mootz HD. Cyclic peptides made by linking synthetic and genetically encoded fragments. Chembiochem : a European Journal of Chemical Biology. PMID 26691013 DOI: 10.1002/Cbic.201500673 |
0.816 |
|
| 2015 |
Bachmann AL, Mootz HD. An Unprecedented Combination of Serine and Cysteine Nucleophiles in a Split Intein with an Atypical Split Site. The Journal of Biological Chemistry. PMID 26453311 DOI: 10.1074/Jbc.M115.677237 |
0.502 |
|
| 2015 |
Sommer S, Ritterhoff T, Melchior F, Mootz HD. A stable chemical SUMO1-Ubc9 conjugate specifically binds as a thioester mimic to the RanBP2-E3 ligase complex. Chembiochem : a European Journal of Chemical Biology. 16: 1183-9. PMID 25917782 DOI: 10.1002/Cbic.201500011 |
0.305 |
|
| 2015 |
Fischle W, Schwarzer D, Mootz HD. Chemical biology: Chromatin chemistry goes cellular. Nature Chemistry. 7: 371-3. PMID 25901809 DOI: 10.1038/Nchem.2249 |
0.307 |
|
| 2015 |
Bachmann AL, Matern JC, Schütz V, Mootz HD. Chemical-tag labeling of proteins using fully recombinant split inteins. Methods in Molecular Biology (Clifton, N.J.). 1266: 145-59. PMID 25560073 DOI: 10.1007/978-1-4939-2272-7_10 |
0.448 |
|
| 2015 |
Matern JC, Bachmann AL, Thiel IV, Volkmann G, Wasmuth A, Binschik J, Mootz HD. Ligation of synthetic peptides to proteins using semisynthetic protein trans-splicing. Methods in Molecular Biology (Clifton, N.J.). 1266: 129-43. PMID 25560072 DOI: 10.1007/978-1-4939-2272-7_9 |
0.597 |
|
| 2015 |
Böcker JK, Friedel K, Matern JC, Bachmann AL, Mootz HD. Generation of a genetically encoded, photoactivatable intein for the controlled production of cyclic peptides. Angewandte Chemie (International Ed. in English). 54: 2116-20. PMID 25557882 DOI: 10.1002/Anie.201409848 |
0.611 |
|
| 2014 |
Sun X, Li H, Alfermann J, Mootz HD, Yang H. Kinetics profiling of gramicidin S synthetase A, a member of nonribosomal peptide synthetases. Biochemistry. 53: 7983-9. PMID 25437123 DOI: 10.1021/Bi501156M |
0.397 |
|
| 2014 |
Schütz V, Mootz HD. Click-tag and amine-tag: chemical tag approaches for efficient protein labeling in vitro and on live cells using the naturally split Npu DnaE intein. Angewandte Chemie (International Ed. in English). 53: 4113-7. PMID 24615830 DOI: 10.1002/Anie.201309396 |
0.467 |
|
| 2014 |
Thiel IV, Volkmann G, Pietrokovski S, Mootz HD. An atypical naturally split intein engineered for highly efficient protein labeling. Angewandte Chemie (International Ed. in English). 53: 1306-10. PMID 24382817 DOI: 10.1002/Anie.201307969 |
0.53 |
|
| 2014 |
van Treel ND, Mootz HD. SUMOylated RanGAP1 prepared by click chemistry. Journal of Peptide Science : An Official Publication of the European Peptide Society. 20: 121-7. PMID 24338848 DOI: 10.1002/Psc.2591 |
0.433 |
|
| 2013 |
Zettler J, Eppmann S, Busche A, Dikovskaya D, Dötsch V, Mootz HD, Sonntag T. SPLICEFINDER - a fast and easy screening method for active protein trans-splicing positions. Plos One. 8: e72925. PMID 24023792 DOI: 10.1371/Journal.Pone.0072925 |
0.42 |
|
| 2013 |
Wasmuth A, Ludwig C, Mootz HD. Structure-activity studies on the upstream splice junction of a semisynthetic intein. Bioorganic & Medicinal Chemistry. 21: 3495-503. PMID 23618706 DOI: 10.1016/J.Bmc.2013.03.065 |
0.436 |
|
| 2013 |
Sommer S, Weikart ND, Linne U, Mootz HD. Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition. Bioorganic & Medicinal Chemistry. 21: 2511-7. PMID 23535560 DOI: 10.1016/J.Bmc.2013.02.039 |
0.373 |
|
| 2013 |
Binschik J, Mootz HD. Chemical bypass of intein-catalyzed N-S acyl shift in protein splicing. Angewandte Chemie (International Ed. in English). 52: 4260-4. PMID 23468274 DOI: 10.1002/Anie.201208863 |
0.346 |
|
| 2013 |
Volkmann G, Mootz HD. Recent progress in intein research: from mechanism to directed evolution and applications. Cellular and Molecular Life Sciences : Cmls. 70: 1185-206. PMID 22926412 DOI: 10.1007/S00018-012-1120-4 |
0.483 |
|
| 2013 |
Dresselhaus T, Weikart ND, Mootz HD, Waller MP. Naturally and synthetically linked lys48 diubiquitin: A QM/MM study Rsc Advances. 3: 16122-16129. DOI: 10.1039/C3Ra42649A |
0.379 |
|
| 2012 |
Carvajal-Vallejos P, Pallissé R, Mootz HD, Schmidt SR. Unprecedented rates and efficiencies revealed for new natural split inteins from metagenomic sources. The Journal of Biological Chemistry. 287: 28686-96. PMID 22753413 DOI: 10.1074/Jbc.M112.372680 |
0.396 |
|
| 2012 |
Schwarzer D, Ludwig C, Thiel IV, Mootz HD. Probing intein-catalyzed thioester formation by unnatural amino acid substitutions in the active site. Biochemistry. 51: 233-42. PMID 22182201 DOI: 10.1021/Bi2014823 |
0.402 |
|
| 2012 |
Weikart ND, Sommer S, Mootz HD. Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding. Chemical Communications (Cambridge, England). 48: 296-8. PMID 22095407 DOI: 10.1039/C1Cc15834A |
0.346 |
|
| 2011 |
Sommer S, Weikart ND, Brockmeyer A, Janning P, Mootz HD. Expanded click conjugation of recombinant proteins with ubiquitin-like modifiers reveals altered substrate preference of SUMO2-modified Ubc9. Angewandte Chemie (International Ed. in English). 50: 9888-92. PMID 21898723 DOI: 10.1002/Anie.201102531 |
0.444 |
|
| 2011 |
Appleby-Tagoe JH, Thiel IV, Wang Y, Wang Y, Mootz HD, Liu XQ. Highly efficient and more general cis- and trans-splicing inteins through sequential directed evolution. The Journal of Biological Chemistry. 286: 34440-7. PMID 21832069 DOI: 10.1074/Jbc.M111.277350 |
0.453 |
|
| 2011 |
Dhar T, Kurpiers T, Mootz HD. Extending the scope of site-specific cysteine bioconjugation by appending a prelabeled cysteine tag to proteins using protein trans-splicing. Methods in Molecular Biology (Clifton, N.J.). 751: 131-42. PMID 21674329 DOI: 10.1007/978-1-61779-151-2_9 |
0.455 |
|
| 2011 |
Sonntag T, Mootz HD. An intein-cassette integration approach used for the generation of a split TEV protease activated by conditional protein splicing. Molecular Biosystems. 7: 2031-9. PMID 21487580 DOI: 10.1039/C1Mb05025G |
0.458 |
|
| 2011 |
Binschik J, Zettler J, Mootz HD. Photocontrol of protein activity mediated by the cleavage reaction of a split intein. Angewandte Chemie (International Ed. in English). 50: 3249-52. PMID 21384476 DOI: 10.1002/Anie.201007078 |
0.366 |
|
| 2011 |
Dhar T, Mootz HD. Modification of transmembrane and GPI-anchored proteins on living cells by efficient protein trans-splicing using the Npu DnaE intein. Chemical Communications (Cambridge, England). 47: 3063-5. PMID 21234473 DOI: 10.1039/C0Cc04172F |
0.403 |
|
| 2010 |
Garbe D, Thiel IV, Mootz HD. Protein trans-splicing on an M13 bacteriophage: towards directed evolution of a semisynthetic split intein by phage display. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 575-81. PMID 20862725 DOI: 10.1002/Psc.1243 |
0.578 |
|
| 2010 |
Weikart ND, Mootz HD. Generation of site-specific and enzymatically stable conjugates of recombinant proteins with ubiquitin-like modifiers by the Cu(I)-catalyzed azide-alkyne cycloaddition. Chembiochem : a European Journal of Chemical Biology. 11: 774-7. PMID 20209558 DOI: 10.1002/Cbic.200900738 |
0.337 |
|
| 2010 |
Zettler J, Mootz HD. Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases. The Febs Journal. 277: 1159-71. PMID 20121951 DOI: 10.1111/J.1742-4658.2009.07551.X |
0.532 |
|
| 2009 |
Mootz HD. Split inteins as versatile tools for protein semisynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 2579-89. PMID 19708049 DOI: 10.1002/Cbic.200900370 |
0.385 |
|
| 2009 |
Ludwig C, Schwarzer D, Zettler J, Garbe D, Janning P, Czeslik C, Mootz HD. Semisynthesis of proteins using split inteins. Methods in Enzymology. 462: 77-96. PMID 19632470 DOI: 10.1016/S0076-6879(09)62004-8 |
0.581 |
|
| 2009 |
Brenzel S, Cebi M, Reiss P, Koert U, Mootz HD. Expanding the scope of protein trans-splicing to fragment ligation of an integral membrane protein: towards modulation of porin-based ion channels by chemical modification. Chembiochem : a European Journal of Chemical Biology. 10: 983-6. PMID 19322843 DOI: 10.1002/Cbic.200900039 |
0.319 |
|
| 2009 |
Zettler J, Schütz V, Mootz HD. The naturally split Npu DnaE intein exhibits an extraordinarily high rate in the protein trans-splicing reaction. Febs Letters. 583: 909-14. PMID 19302791 DOI: 10.1016/J.Febslet.2009.02.003 |
0.36 |
|
| 2009 |
Kurpiers T, Mootz HD. Bioorthogonal ligation in the spotlight. Angewandte Chemie (International Ed. in English). 48: 1729-31. PMID 19148914 DOI: 10.1002/Anie.200805454 |
0.308 |
|
| 2008 |
Rosenfeldt G, Viana RM, Mootz HD, von Arnim AG, Batschauer A. Chemically induced and light-independent cryptochrome photoreceptor activation. Molecular Plant. 1: 4-14. PMID 20031911 DOI: 10.1093/Mp/Ssm002 |
0.355 |
|
| 2008 |
Kurpiers T, Mootz HD. Site-specific chemical modification of proteins with a prelabelled cysteine tag using the artificially split Mxe GyrA intein. Chembiochem : a European Journal of Chemical Biology. 9: 2317-25. PMID 18756552 DOI: 10.1002/Cbic.200800319 |
0.491 |
|
| 2008 |
Ludwig C, Schwarzer D, Mootz HD. Interaction studies and alanine scanning analysis of a semi-synthetic split intein reveal thiazoline ring formation from an intermediate of the protein splicing reaction. The Journal of Biological Chemistry. 283: 25264-72. PMID 18625708 DOI: 10.1074/Jbc.M802972200 |
0.453 |
|
| 2007 |
Kurpiers T, Mootz HD. Regioselective cysteine bioconjugation by appending a labeled cystein tag to a protein by using protein splicing in trans. Angewandte Chemie (International Ed. in English). 46: 5234-7. PMID 17538921 DOI: 10.1002/Anie.200700719 |
0.414 |
|
| 2007 |
Kurpiers T, Mootz H. Regioselektive Cysteinbiokonjugation durch Anhängen eines modifizierten Cystein-tags an ein Protein mithilfe vontrans-Proteinspleißen Angewandte Chemie. 119: 5327-5330. DOI: 10.1002/Ange.200700719 |
0.406 |
|
| 2006 |
Ludwig C, Pfeiff M, Linne U, Mootz HD. Ligation of a synthetic peptide to the N terminus of a recombinant protein using semisynthetic protein trans-splicing. Angewandte Chemie (International Ed. in English). 45: 5218-21. PMID 16823791 DOI: 10.1002/Anie.200600570 |
0.585 |
|
| 2006 |
Brenzel S, Kurpiers T, Mootz HD. Engineering artificially split inteins for applications in protein chemistry: biochemical characterization of the split Ssp DnaB intein and comparison to the split Sce VMA intein. Biochemistry. 45: 1571-8. PMID 16460004 DOI: 10.1021/Bi051697+ |
0.5 |
|
| 2006 |
Roelfes G, Mootz HD. Probing the molecular basis of protein function through chemistry. Chembiochem : a European Journal of Chemical Biology. 7: 545-9. PMID 16453350 DOI: 10.1002/Cbic.200500547 |
0.355 |
|
| 2006 |
Ludwig C, Pfeiff M, Linne U, Mootz HD. Ligation eines synthetischen Peptids an den N-Terminus eines rekombinanten Proteins durch semisynthetischestrans-Proteinspleißen Angewandte Chemie. 118: 5343-5347. DOI: 10.1002/Ange.200600570 |
0.573 |
|
| 2005 |
Brenzel S, Mootz HD. Design of an intein that can be inhibited with a small molecule ligand. Journal of the American Chemical Society. 127: 4176-7. PMID 15783192 DOI: 10.1021/Ja043501J |
0.52 |
|
| 2004 |
Mootz HD, Blum ES, Muir TW. Activation of an autoregulated protein kinase by conditional protein splicing. Angewandte Chemie (International Ed. in English). 43: 5189-92. PMID 15455415 DOI: 10.1002/Anie.200460941 |
0.562 |
|
| 2004 |
Gruenewald S, Mootz HD, Stehmeier P, Stachelhaus T. In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. Applied and Environmental Microbiology. 70: 3282-91. PMID 15184122 DOI: 10.1128/Aem.70.6.3282-3291.2004 |
0.51 |
|
| 2003 |
Mootz HD, Blum ES, Tyszkiewicz AB, Muir TW. Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. Journal of the American Chemical Society. 125: 10561-9. PMID 12940738 DOI: 10.1021/Ja0362813 |
0.645 |
|
| 2003 |
Linne U, Stein DB, Mootz HD, Marahiel MA. Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry. 42: 5114-24. PMID 12718555 DOI: 10.1021/Bi034223O |
0.427 |
|
| 2002 |
Schwarzer D, Mootz HD, Linne U, Marahiel MA. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proceedings of the National Academy of Sciences of the United States of America. 99: 14083-8. PMID 12384573 DOI: 10.1073/Pnas.212382199 |
0.547 |
|
| 2002 |
Mootz HD, Schwarzer D, Marahiel MA. Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem : a European Journal of Chemical Biology. 3: 490-504. PMID 12325005 DOI: 10.1002/1439-7633(20020603)3:6<490::Aid-Cbic490>3.0.Co;2-N |
0.544 |
|
| 2002 |
Mootz HD, Kessler N, Linne U, Eppelmann K, Schwarzer D, Marahiel MA. Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes. Journal of the American Chemical Society. 124: 10980-1. PMID 12224936 DOI: 10.1021/Ja027276M |
0.56 |
|
| 2002 |
Mootz HD, Muir TW. Protein splicing triggered by a small molecule. Journal of the American Chemical Society. 124: 9044-5. PMID 12148996 DOI: 10.1021/Ja026769O |
0.589 |
|
| 2002 |
Mootz HD, Schörgendorfer K, Marahiel MA. Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. Fems Microbiology Letters. 213: 51-7. PMID 12127488 DOI: 10.1111/J.1574-6968.2002.Tb11285.X |
0.372 |
|
| 2001 |
Schwarzer D, Mootz HD, Marahiel MA. Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases. Chemistry & Biology. 8: 997-1010. PMID 11590023 DOI: 10.1016/S1074-5521(01)00068-0 |
0.489 |
|
| 2001 |
Mootz HD, Finking R, Marahiel MA. 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. The Journal of Biological Chemistry. 276: 37289-98. PMID 11489886 DOI: 10.1074/Jbc.M103556200 |
0.468 |
|
| 2000 |
Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT. Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase. Nature. 407: 215-8. PMID 11001063 DOI: 10.1038/35025116 |
0.406 |
|
| 2000 |
Mootz HD, Schwarzer D, Marahiel MA. Construction of hybrid peptide synthetases by module and domain fusions. Proceedings of the National Academy of Sciences of the United States of America. 97: 5848-53. PMID 10811885 DOI: 10.1073/Pnas.100075897 |
0.492 |
|
| 1999 |
Mootz HD, Marahiel MA. Design and application of multimodular peptide synthetases. Current Opinion in Biotechnology. 10: 341-8. PMID 10449311 DOI: 10.1016/S0958-1669(99)80062-7 |
0.568 |
|
| 1999 |
Stachelhaus T, Mootz HD, Marahiel MA. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chemistry & Biology. 6: 493-505. PMID 10421756 DOI: 10.1016/S1074-5521(99)80082-9 |
0.513 |
|
| 1998 |
Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA. Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain. The Journal of Biological Chemistry. 273: 22773-81. PMID 9712910 DOI: 10.1074/Jbc.273.35.22773 |
0.517 |
|
| 1997 |
Marahiel MA, Stachelhaus T, Mootz HD. Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis. Chemical Reviews. 97: 2651-2674. PMID 11851476 DOI: 10.1021/Cr960029E |
0.562 |
|
| 1997 |
Mootz HD, Marahiel MA. Biosynthetic systems for nonribosomal peptide antibiotic assembly. Current Opinion in Chemical Biology. 1: 543-51. PMID 9667890 DOI: 10.1016/S1367-5931(97)80051-8 |
0.58 |
|
| 1997 |
Mootz HD, Marahiel MA. The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. Journal of Bacteriology. 179: 6843-50. PMID 9352938 DOI: 10.1128/Jb.179.21.6843-6850.1997 |
0.409 |
|
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