Mohamed A. Marahiel - Publications

Affiliations: 
Philipps University Marburg, Marburg, Hessen, Germany 

234 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bratovanov EV, Ishida K, Heinze B, Pidot SJ, Stinear TP, Hegemann JD, Marahiel MA, Hertweck C. Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria. Acs Chemical Biology. PMID 31800204 DOI: 10.1021/Acschembio.9B00805  0.452
2018 Romano M, Fusco G, Choudhury HG, Mehmood S, Robinson CV, Zirah S, Hegemann JD, Lescop E, Marahiel MA, Rebuffat S, De Simone A, Beis K. Structural basis for natural product selection and export by bacterial ABC transporters. Acs Chemical Biology. PMID 29757605 DOI: 10.1021/Acschembio.8B00226  0.377
2018 Fouque KJD, Lavanant H, Zirah S, Hegemann JD, Fage CD, Marahiel MA, Rebuffat S, Afonso C. General rules of fragmentation evidencing lasso structures in CID and ETD Analyst. 143: 1157-1170. PMID 29404537 DOI: 10.1039/C7An02052J  0.458
2017 Fouque KJD, Lavanant H, Zirah S, Hegemann JD, Zimmermann M, Marahiel MA, Rebuffat S, Afonso C. Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives. Journal of the American Society For Mass Spectrometry. 28: 315-322. PMID 27812920 DOI: 10.1007/S13361-016-1524-8  0.413
2016 Bloudoff K, Fage CD, Marahiel MA, Schmeing TM. Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27994138 DOI: 10.1073/Pnas.1614191114  0.488
2016 Zhu S, Fage CD, Hegemann JD, Mielcarek A, Yan D, Linne U, Marahiel MA. The B1 Protein Guides the Biosynthesis of a Lasso Peptide. Scientific Reports. 6: 35604. PMID 27752134 DOI: 10.1038/Srep35604  0.46
2016 Fage CD, Hegemann JD, Nebel AJ, Steinbach RM, Zhu S, Linne U, Harms K, Bange G, Marahiel MA. Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase. Angewandte Chemie (International Ed. in English). PMID 27611791 DOI: 10.1002/Anie.201605232  0.471
2016 Zhu S, Fage CD, Hegemann JD, Yan D, Marahiel MA. Dual substrate-controlled kinase activity leads to polyphosphorylated lasso peptides. Febs Letters. PMID 27585551 DOI: 10.1002/1873-3468.12386  0.449
2016 Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA. Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU. Plos One. 11: e0158749. PMID 27382962 DOI: 10.1371/Journal.Pone.0158749  0.317
2016 Zhu S, Hegemann JD, Fage CD, Zimmermann M, Xie X, Linne U, Marahiel MA. Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin. The Journal of Biological Chemistry. PMID 27151214 DOI: 10.1074/Jbc.M116.722108  0.461
2016 Hegemann JD, Fage CD, Zhu S, Harms K, Di Leva FS, Novellino E, Marinelli L, Marahiel MA. The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II. Molecular Biosystems. PMID 26863937 DOI: 10.1039/C6Mb00081A  0.334
2016 Marahiel MA. A structural model for multimodular NRPS assembly lines. Natural Product Reports. 33: 136-40. PMID 26429504 DOI: 10.1039/C5Np00082C  0.421
2015 Steinchen W, Schuhmacher JS, Altegoer F, Fage CD, Srinivasan V, Linne U, Marahiel MA, Bange G. Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone. Proceedings of the National Academy of Sciences of the United States of America. 112: 13348-53. PMID 26460002 DOI: 10.1073/Pnas.1505271112  0.361
2015 Giessen TW, Marahiel MA. Rational and combinatorial tailoring of bioactive cyclic dipeptides. Frontiers in Microbiology. 6: 785. PMID 26284060 DOI: 10.3389/Fmicb.2015.00785  0.717
2015 Hegemann JD, Zimmermann M, Xie X, Marahiel MA. Lasso Peptides: An Intriguing Class of Bacterial Natural Products. Accounts of Chemical Research. PMID 26079760 DOI: 10.1021/Acs.Accounts.5B00156  0.504
2015 Wieckowski BM, Hegemann JD, Mielcarek A, Boss L, Burghaus O, Marahiel MA. The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation. Febs Letters. 589: 1802-6. PMID 26026269 DOI: 10.1016/J.Febslet.2015.05.032  0.403
2015 Giessen TW, Altegoer F, Nebel AJ, Steinbach RM, Bange G, Marahiel MA. A synthetic adenylation-domain-based tRNA-aminoacylation catalyst. Angewandte Chemie (International Ed. in English). 54: 2492-6. PMID 25583137 DOI: 10.1002/Anie.201410047  0.726
2015 Jeanne Dit Fouque K, Afonso C, Zirah S, Hegemann JD, Zimmermann M, Marahiel MA, Rebuffat S, Lavanant H. Ion mobility-mass spectrometry of lasso peptides: signature of a rotaxane topology. Analytical Chemistry. 87: 1166-72. PMID 25495527 DOI: 10.1021/Ac503772N  0.336
2014 Giessen TW, Marahiel MA. The tRNA-dependent biosynthesis of modified cyclic dipeptides. International Journal of Molecular Sciences. 15: 14610-31. PMID 25196600 DOI: 10.3390/Ijms150814610  0.746
2014 Hegemann JD, De Simone M, Zimmermann M, Knappe TA, Xie X, Di Leva FS, Marinelli L, Novellino E, Zahler S, Kessler H, Marahiel MA. Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. Journal of Medicinal Chemistry. 57: 5829-34. PMID 24949551 DOI: 10.1021/Jm5004478  0.342
2014 Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V. Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chemistry & Biology. 21: 552-62. PMID 24704508 DOI: 10.1016/J.Chembiol.2014.02.014  0.363
2014 Hegemann JD, Zimmermann M, Zhu S, Steuber H, Harms K, Xie X, Marahiel MA. Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring. Angewandte Chemie (International Ed. in English). 53: 2230-4. PMID 24446383 DOI: 10.1002/Anie.201309267  0.453
2014 Knappe T, Linne U, Xie X, Marahiel M. Lasso peptide based integrin inhibitor: Microcin J25 variant with RGD substitution of Gly12-Ile13-Gly14 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Mmt/Pdb  0.41
2014 Zimmermann M, Hegemann JD, Xie X, Marahiel MA. Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation Chemical Science. 5: 4032-4043. DOI: 10.1039/C4Sc01428F  0.484
2013 Bosello M, Zeyadi M, Kraas FI, Linne U, Xie X, Marahiel MA. Structural characterization of the heterobactin siderophores from Rhodococcus erythropolis PR4 and elucidation of their biosynthetic machinery. Journal of Natural Products. 76: 2282-90. PMID 24274668 DOI: 10.1021/Np4006579  0.439
2013 Hegemann JD, Zimmermann M, Zhu S, Klug D, Marahiel MA. Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry. Biopolymers. 100: 527-42. PMID 23897438 DOI: 10.1002/Bip.22326  0.457
2013 Flühe L, Marahiel MA. Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis. Current Opinion in Chemical Biology. 17: 605-12. PMID 23891473 DOI: 10.1016/J.Cbpa.2013.06.031  0.364
2013 Giessen TW, von Tesmar AM, Marahiel MA. Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides. Chemistry & Biology. 20: 828-38. PMID 23790493 DOI: 10.1016/J.Chembiol.2013.04.017  0.697
2013 Giessen TW, von Tesmar AM, Marahiel MA. A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines. Biochemistry. 52: 4274-83. PMID 23705796 DOI: 10.1021/Bi4004827  0.739
2013 Zimmermann M, Hegemann JD, Xie X, Marahiel MA. The astexin-1 lasso peptides: biosynthesis, stability, and structural studies. Chemistry & Biology. 20: 558-69. PMID 23601645 DOI: 10.1016/J.Chembiol.2013.03.013  0.453
2013 Flühe L, Burghaus O, Wieckowski BM, Giessen TW, Linne U, Marahiel MA. Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor. Journal of the American Chemical Society. 135: 959-62. PMID 23282011 DOI: 10.1021/Ja310542G  0.72
2013 Miethke M, Kraushaar T, Marahiel MA. Uptake of xenosiderophores in Bacillus subtilis occurs with high affinity and enhances the folding stabilities of substrate binding proteins. Febs Letters. 587: 206-13. PMID 23220087 DOI: 10.1016/J.Febslet.2012.11.027  0.316
2013 Hegemann JD, Zimmermann M, Xie X, Marahiel MA. Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster. Journal of the American Chemical Society. 135: 210-22. PMID 23214991 DOI: 10.1021/Ja308173B  0.471
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Marahiel MA, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.529
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Marahiel MA, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.517
2012 Giessen TW, Franke KB, Knappe TA, Kraas FI, Bosello M, Xie X, Linne U, Marahiel MA. Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum. Journal of Natural Products. 75: 905-14. PMID 22578145 DOI: 10.1021/Np300046K  0.744
2012 Pérot-Taillandier M, Zirah S, Rebuffat S, Linne U, Marahiel MA, Cole RB, Tabet JC, Afonso C. Determination of peptide topology through time-resolved double-resonance under electron capture dissociation conditions. Analytical Chemistry. 84: 4957-64. PMID 22571326 DOI: 10.1021/Ac300607Y  0.377
2012 Yan KP, Li Y, Zirah S, Goulard C, Knappe TA, Marahiel MA, Rebuffat S. Dissecting the maturation steps of the lasso peptide microcin J25 in vitro. Chembiochem : a European Journal of Chemical Biology. 13: 1046-52. PMID 22488892 DOI: 10.1002/Cbic.201200016  0.497
2012 Bosello M, Mielcarek A, Giessen TW, Marahiel MA. An enzymatic pathway for the biosynthesis of the formylhydroxyornithine required for rhodochelin iron coordination. Biochemistry. 51: 3059-66. PMID 22439765 DOI: 10.1021/Bi201837F  0.68
2012 Flühe L, Knappe TA, Gattner MJ, Schäfer A, Burghaus O, Linne U, Marahiel MA. The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nature Chemical Biology. 8: 350-7. PMID 22366720 DOI: 10.1038/Nchembio.798  0.371
2012 Xie X, Marahiel MA. NMR as an effective tool for the structure determination of lasso peptides. Chembiochem : a European Journal of Chemical Biology. 13: 621-5. PMID 22278977 DOI: 10.1002/Cbic.201100754  0.401
2012 Giessen TW, Marahiel MA. Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity. Febs Letters. 586: 2065-75. PMID 22273582 DOI: 10.1016/J.Febslet.2012.01.017  0.736
2012 Kraas FI, Giessen TW, Marahiel MA. Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA. Febs Letters. 586: 283-8. PMID 22245678 DOI: 10.1016/J.Febslet.2012.01.003  0.734
2012 Xie X, Marahiel MA. Cover Picture: NMR as an Effective Tool for the Structure Determination of Lasso Peptides (ChemBioChem 5/2012) Chembiochem. 13: 605-605. DOI: 10.1002/Cbic.201290013  0.4
2011 Miethke M, Hou J, Marahiel MA. The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry. 50: 10951-64. PMID 22098718 DOI: 10.1021/Bi201517H  0.324
2011 Knappe TA, Manzenrieder F, Mas-Moruno C, Linne U, Sasse F, Kessler H, Xie X, Marahiel MA. Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist Angewandte Chemie. 50: 8714-8717. PMID 21812076 DOI: 10.1002/Anie.201102190  0.41
2011 Peuckert F, Ramos-Vega AL, Miethke M, Schwörer CJ, Albrecht AG, Oberthür M, Marahiel MA. The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates. Chemistry & Biology. 18: 907-19. PMID 21802011 DOI: 10.1016/J.Chembiol.2011.05.006  0.349
2011 Robbel L, Helmetag V, Knappe TA, Marahiel MA. Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry. 50: 6073-80. PMID 21650455 DOI: 10.1021/Bi200699X  0.308
2011 Giessen TW, Kraas FI, Marahiel MA. A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry. 50: 5680-92. PMID 21612226 DOI: 10.1021/Bi2006114  0.734
2011 Hou J, Robbel L, Marahiel MA. Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chemistry & Biology. 18: 655-64. PMID 21609846 DOI: 10.1016/J.Chembiol.2011.02.012  0.403
2011 van der Ploeg R, Mäder U, Homuth G, Schaffer M, Denham EL, Monteferrante CG, Miethke M, Marahiel MA, Harwood CR, Winter T, Hecker M, Antelmann H, van Dijl JM. Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. Plos One. 6: e18140. PMID 21479178 DOI: 10.1371/Journal.Pone.0018140  0.329
2011 Zirah S, Afonso C, Linne U, Knappe TA, Marahiel MA, Rebuffat S, Tabet JC. Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides. Journal of the American Society For Mass Spectrometry. 22: 467-79. PMID 21472565 DOI: 10.1007/S13361-010-0028-1  0.428
2011 Kuznedelov K, Semenova E, Knappe TA, Mukhamedyarov D, Srivastava A, Chatterjee S, Ebright RH, Marahiel MA, Severinov K. The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. Journal of Molecular Biology. 412: 842-8. PMID 21396375 DOI: 10.1016/J.Jmb.2011.02.060  0.448
2011 Bosello M, Robbel L, Linne U, Xie X, Marahiel MA. Biosynthesis of the siderophore rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococcus jostii RHA1. Journal of the American Chemical Society. 133: 4587-95. PMID 21381663 DOI: 10.1021/Ja1109453  0.352
2011 Albrecht AG, Peuckert F, Landmann H, Miethke M, Seubert A, Marahiel MA. Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis. Febs Letters. 585: 465-70. PMID 21236255 DOI: 10.1016/J.Febslet.2011.01.005  0.33
2010 Kraas FI, Helmetag V, Wittmann M, Strieker M, Marahiel MA. Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chemistry & Biology. 17: 872-80. PMID 20797616 DOI: 10.1016/J.Chembiol.2010.06.015  0.414
2010 Strieker M, Tanović A, Marahiel MA. Nonribosomal peptide synthetases: structures and dynamics. Current Opinion in Structural Biology. 20: 234-40. PMID 20153164 DOI: 10.1016/J.Sbi.2010.01.009  0.482
2010 Enck S, Kopp F, Marahiel MA, Geyer A. The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Organic & Biomolecular Chemistry. 8: 559-63. PMID 20090972 DOI: 10.1039/B917549K  0.442
2010 Winterberg B, Uhlmann S, Linne U, Lessing F, Marahiel MA, Eichhorn H, Kahmann R, Schirawski J. Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Molecular Microbiology. 75: 1260-71. PMID 20070524 DOI: 10.1111/J.1365-2958.2010.07048.X  0.389
2010 Robbel L, Knappe TA, Linne U, Xie X, Marahiel MA. Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea. The Febs Journal. 277: 663-76. PMID 20050920 DOI: 10.1111/J.1742-4658.2009.07512.X  0.439
2010 Knappe TA, Linne U, Xie X, Marahiel MA. The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides. Febs Letters. 584: 785-9. PMID 20043911 DOI: 10.1016/J.Febslet.2009.12.046  0.407
2009 Knappe TA, Linne U, Robbel L, Marahiel MA. Insights into the biosynthesis and stability of the lasso peptide capistruin. Chemistry & Biology. 16: 1290-8. PMID 20064439 DOI: 10.1016/J.Chembiol.2009.11.009  0.49
2009 Marahiel MA. Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 15: 799-807. PMID 19827002 DOI: 10.1002/Psc.1183  0.51
2009 Strieker M, Nolan EM, Walsh CT, Marahiel MA. Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. Journal of the American Chemical Society. 131: 13523-30. PMID 19722489 DOI: 10.1021/Ja9054417  0.542
2009 Roberts AA, Copp JN, Marahiel MA, Neilan BA. The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. Chembiochem : a European Journal of Chemical Biology. 10: 1869-77. PMID 19562788 DOI: 10.1002/Cbic.200900095  0.368
2009 Helmetag V, Samel SA, Thomas MG, Marahiel MA, Essen LO. Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. The Febs Journal. 276: 3669-82. PMID 19490124 DOI: 10.1111/J.1742-4658.2009.07085.X  0.366
2009 Duquesne S, Destoumieux-Garzón D, Zirah S, Knappe TA, Goulard C, Peduzzi J, Marahiel MA, Rebuffat S. Post-translational modification and folding of a lasso-type gene-encoded antimicrobial peptide require two enzymes only in Escherichia coli. Advances in Experimental Medicine and Biology. 611: 35-6. PMID 19400082 DOI: 10.1007/978-0-387-73657-0_15  0.45
2009 Marahiel MA, Essen L‐. Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods in Enzymology. 458: 337-351. PMID 19374989 DOI: 10.1016/S0076-6879(09)04813-7  0.504
2009 Hur GH, Meier JL, Baskin J, Codelli JA, Bertozzi CR, Marahiel MA, Burkart MD. Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chemistry & Biology. 16: 372-81. PMID 19345117 DOI: 10.1016/J.Chembiol.2009.02.009  0.392
2009 Robbel L, Hoyer KM, Marahiel MA. TioS T-TE--a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides. The Febs Journal. 276: 1641-53. PMID 19220461 DOI: 10.1111/J.1742-4658.2009.06897.X  0.434
2009 Strieker M, Marahiel MA. The structural diversity of acidic lipopeptide antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 607-16. PMID 19156787 DOI: 10.1002/Cbic.200800546  0.381
2008 Wittmann M, Linne U, Pohlmann V, Marahiel MA. Role of DptE and DptF in the lipidation reaction of daptomycin. The Febs Journal. 275: 5343-54. PMID 18959760 DOI: 10.1111/J.1742-4658.2008.06664.X  0.414
2008 Yonus H, Neumann P, Zimmermann S, May JJ, Marahiel MA, Stubbs MT. Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. The Journal of Biological Chemistry. 283: 32484-91. PMID 18784082 DOI: 10.1074/Jbc.M800557200  0.432
2008 Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V. Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature. 454: 907-11. PMID 18704089 DOI: 10.1038/Nature07161  0.543
2008 Knappe TA, Linne U, Zirah S, Rebuffat S, Xie X, Marahiel MA. Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. Journal of the American Chemical Society. 130: 11446-54. PMID 18671394 DOI: 10.1021/Ja802966G  0.476
2008 Tanovic A, Samel SA, Essen LO, Marahiel MA. Crystal structure of the termination module of a nonribosomal peptide synthetase. Science (New York, N.Y.). 321: 659-63. PMID 18583577 DOI: 10.1126/Science.1159850  0.459
2008 Miethke M, Schmidt S, Marahiel MA. The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. Journal of Bacteriology. 190: 5143-52. PMID 18502870 DOI: 10.1128/Jb.00464-08  0.303
2008 Pohlmann V, Marahiel MA. Delta-amino group hydroxylation of L-ornithine during coelichelin biosynthesis. Organic & Biomolecular Chemistry. 6: 1843-8. PMID 18452021 DOI: 10.1039/B801016A  0.357
2008 Samel SA, Marahiel MA, Essen LO. How to tailor non-ribosomal peptide products--new clues about the structures and mechanisms of modifying enzymes. Molecular Biosystems. 4: 387-93. PMID 18414736 DOI: 10.1039/B717538H  0.504
2008 Kopp F, Linne U, Oberthür M, Marahiel MA. Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. Journal of the American Chemical Society. 130: 2656-66. PMID 18237171 DOI: 10.1021/Ja078081N  0.414
2008 Strieker M, Essen LO, Walsh CT, Marahiel MA. Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. Chembiochem : a European Journal of Chemical Biology. 9: 374-6. PMID 18213565 DOI: 10.1002/Cbic.200700557  0.453
2007 Kopp F, Marahiel MA. Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides. Current Opinion in Biotechnology. 18: 513-20. PMID 17997093 DOI: 10.1016/J.Copbio.2007.09.009  0.443
2007 Fujimori DG, Hrvatin S, Neumann CS, Strieker M, Marahiel MA, Walsh CT. Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proceedings of the National Academy of Sciences of the United States of America. 104: 16498-503. PMID 17940045 DOI: 10.1073/Pnas.0708242104  0.545
2007 Teichmann B, Linne U, Hewald S, Marahiel MA, Bölker M. A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Molecular Microbiology. 66: 525-33. PMID 17850255 DOI: 10.1111/J.1365-2958.2007.05941.X  0.382
2007 Mahlert C, Kopp F, Thirlway J, Micklefield J, Marahiel MA. Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. Journal of the American Chemical Society. 129: 12011-8. PMID 17784761 DOI: 10.1021/Ja074427I  0.375
2007 Kopp F, Marahiel MA. Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Natural Product Reports. 24: 735-49. PMID 17653357 DOI: 10.1039/B613652B  0.482
2007 Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO. Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure (London, England : 1993). 15: 781-92. PMID 17637339 DOI: 10.1016/J.Str.2007.05.008  0.462
2007 Paungmoung P, Punya J, Pongpattanakitshote S, Jeamton W, Vichisoonthonkul T, Bhumiratana S, Tanticharoen M, Linne U, Marahiel MA, Cheevadhanarak S. Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA. Fems Microbiology Letters. 274: 260-8. PMID 17623029 DOI: 10.1111/J.1574-6968.2007.00843.X  0.417
2007 Azim-Zadeh O, Hillebrecht A, Linne U, Marahiel MA, Klebe G, Lingelbach K, Nyalwidhe J. Use of biotin derivatives to probe conformational changes in proteins. The Journal of Biological Chemistry. 282: 21609-17. PMID 17545162 DOI: 10.1074/Jbc.M610921200  0.328
2007 Wiegeshoff F, Marahiel MA. Characterization of a mutation in the acetolactate synthase of Bacillus subtilis that causes a cold-sensitive phenotype. Fems Microbiology Letters. 272: 30-4. PMID 17488331 DOI: 10.1111/J.1574-6968.2007.00739.X  0.303
2007 Strieker M, Kopp F, Mahlert C, Essen LO, Marahiel MA. Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. Acs Chemical Biology. 2: 187-96. PMID 17373765 DOI: 10.1021/Cb700012Y  0.464
2007 Copp JN, Roberts AA, Marahiel MA, Neilan BA. Characterization of PPTNs, a Cyanobacterial Phosphopantetheinyl Transferase from Nodularia spumigena NSOR10 Journal of Bacteriology. 189: 3133-3139. PMID 17307858 DOI: 10.1128/Jb.01850-06  0.458
2007 Linne U, Schäfer A, Stubbs MT, Marahiel MA. Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains. Febs Letters. 581: 905-10. PMID 17303131 DOI: 10.1016/J.Febslet.2007.01.066  0.448
2007 Hoyer KM, Mahlert C, Marahiel MA. The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chemistry & Biology. 14: 13-22. PMID 17254948 DOI: 10.1016/J.Chembiol.2006.10.011  0.436
2007 Bisseret P, Thielges S, Bourg S, Miethke M, Marahiel MA, Eustache J. Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis Tetrahedron Letters. 48: 6080-6083. DOI: 10.1016/J.Tetlet.2007.06.150  0.326
2006 Kopp F, Mahlert C, Grünewald J, Marahiel MA. Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. Journal of the American Chemical Society. 128: 16478-9. PMID 17177378 DOI: 10.1021/Ja0667458  0.467
2006 Miethke M, Westers H, Blom EJ, Kuipers OP, Marahiel MA. Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis Journal of Bacteriology. 188: 8655-8657. PMID 17012385 DOI: 10.1128/Jb.01049-06  0.331
2006 Stein DB, Linne U, Hahn M, Marahiel MA. Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis. Chembiochem : a European Journal of Chemical Biology. 7: 1807-14. PMID 16952189 DOI: 10.1002/Cbic.200600192  0.411
2006 Kopp F, Grünewald J, Mahlert C, Marahiel MA. Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry. 45: 10474-81. PMID 16939199 DOI: 10.1021/Bi0609422  0.468
2006 Wagner B, Schumann D, Linne U, Koert U, Marahiel MA. Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. Journal of the American Chemical Society. 128: 10513-10520. PMID 16895418 DOI: 10.1021/Ja062906W  0.451
2006 Hewald S, Linne U, Scherer M, Marahiel MA, Kämper J, Bölker M. Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Applied and Environmental Microbiology. 72: 5469-5477. PMID 16885300 DOI: 10.1128/Aem.00506-06  0.39
2006 Schoenafinger G, Schracke N, Linne U, Marahiel MA. Formylation domain: an essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. Journal of the American Chemical Society. 128: 7406-7407. PMID 16756271 DOI: 10.1021/Ja0611240  0.481
2006 Samel SA, Wagner B, Marahiel MA, Essen L. The Thioesterase Domain of the Fengycin Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-ribosomal Lipopeptide Journal of Molecular Biology. 359: 876-889. PMID 16697411 DOI: 10.1016/J.Jmb.2006.03.062  0.486
2006 Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V. Conformational switches modulate protein interactions in peptide antibiotic synthetases Science. 312: 273-276. PMID 16614225 DOI: 10.1126/Science.1122928  0.382
2006 Grünewald J, Marahiel MA. Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiology and Molecular Biology Reviews : Mmbr. 70: 121-46. PMID 16524919 DOI: 10.1128/Mmbr.70.1.121-146.2006  0.507
2006 Wagner B, Sieber SA, Baumann M, Marahiel MA. Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem : a European Journal of Chemical Biology. 7: 595-7. PMID 16485318 DOI: 10.1002/Cbic.200500495  0.518
2006 Miethke M, Bisseret P, Beckering CL, Vignard D, Eustache J, Marahiel MA. Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. The Febs Journal. 273: 409-19. PMID 16403027 DOI: 10.1111/J.1742-4658.2005.05077.X  0.397
2006 Hunger K, Beckering CL, Wiegeshoff F, Graumann PL, Marahiel MA. Cold-Induced Putative DEAD Box RNA Helicases CshA and CshB Are Essential for Cold Adaptation and Interact with Cold Shock Protein B in Bacillus subtilis Journal of Bacteriology. 188: 240-248. PMID 16352840 DOI: 10.1128/Jb.188.1.240-248.2006  0.305
2006 Grunewald J, Mahlert C, Kopp F, Marahiel MA. Chemoenzymatic Pathways towards Novel Peptide Antibiotics Anti-Infective Agents in Medicinal Chemistry. 5: 227-243. DOI: 10.2174/187152106777697835  0.409
2005 Stein DB, Linne U, Marahiel MA. Utility of epimerization domains for the redesign of nonribosomal peptide synthetases Febs Journal. 272: 4506-4520. PMID 16128819 DOI: 10.1111/J.1742-4658.2005.04871.X  0.443
2005 Grünewald J, Kopp F, Mahlert C, Linne U, Sieber SA, Marahiel MA. Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains. Chemistry & Biology. 12: 873-81. PMID 16125099 DOI: 10.1016/J.Chembiol.2005.05.019  0.638
2005 Mahlert C, Sieber SA, Grünewald J, Marahiel MA. Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. Journal of the American Chemical Society. 127: 9571-80. PMID 15984884 DOI: 10.1021/Ja051254T  0.668
2005 Schracke N, Linne U, Mahlert C, Marahiel MA. Synthesis of linear gramicidin requires the cooperation of two independent reductases. Biochemistry. 44: 8507-8513. PMID 15938641 DOI: 10.1021/Bi050074T  0.495
2005 Sieber SA, Marahiel MA. Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chemical Reviews. 105: 715-38. PMID 15700962 DOI: 10.1021/Cr0301191  0.607
2004 Grünewald J, Sieber SA, Mahlert C, Linne U, Marahiel MA. Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. Journal of the American Chemical Society. 126: 17025-31. PMID 15612741 DOI: 10.1021/Ja045455T  0.663
2004 Linne U, Marahiel MA. Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases. Methods in Enzymology. 388: 293-315. PMID 15289079 DOI: 10.1016/S0076-6879(04)88024-8  0.472
2004 Finking R, Mofid MR, Marahiel MA. Mutational analysis of peptidyl carrier protein and acyl carrier protein synthase unveils residues involved in protein-protein recognition. Biochemistry. 43: 8946-8956. PMID 15248752 DOI: 10.1021/Bi0496891  0.409
2004 Garbe D, Sieber SA, Bandur NG, Koert U, Marahiel MA. Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres. Chembiochem : a European Journal of Chemical Biology. 5: 1000-3. PMID 15239060 DOI: 10.1002/Cbic.200400042  0.519
2004 Duerfahrt T, Eppelmann K, Müller R, Marahiel MA. Rational Design of a Bimodular Model System for the Investigation of Heterocyclization in Nonribosomal Peptide Biosynthesis Chemistry & Biology. 11: 261-271. PMID 15123287 DOI: 10.1016/J.Chembiol.2004.01.013  0.427
2004 Linne U, Schwarzer D, Schroeder GN, Marahiel MA. Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis European Journal of Biochemistry. 271: 1536-1545. PMID 15066179 DOI: 10.1111/J.1432-1033.2004.04063.X  0.481
2004 Mofid MR, Finking R, Essen LO, Marahiel MA. Structure-based mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry. 43: 4128-4136. PMID 15065855 DOI: 10.1021/Bi036013H  0.436
2004 Grünewald J, Sieber SA, Marahiel MA. Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry. 43: 2915-25. PMID 15005627 DOI: 10.1021/Bi036140D  0.646
2004 Sieber SA, Tao J, Walsh CT, Marahiel MA. Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angewandte Chemie (International Ed. in English). 43: 493-8. PMID 14735544 DOI: 10.1002/Anie.200352787  0.684
2004 Hunger K, Beckering CL, Marahiel MA. Genetic evidence for the temperature-sensing ability of the membrane domain of the Bacillus subtilis histidine kinase DesK. Fems Microbiology Letters. 230: 41-46. PMID 14734164 DOI: 10.1016/S0378-1097(03)00852-8  0.308
2004 Kessler N, Schuhmann H, Morneweg S, Linne U, Marahiel MA. The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains. Journal of Biological Chemistry. 279: 7413-7419. PMID 14670971 DOI: 10.1074/Jbc.M309658200  0.483
2003 Finking R, Marahiel MA. Biosynthesis of nonribosomal peptides Annual Review of Microbiology. 58: 453-488. PMID 15487945 DOI: 10.1146/Annurev.Micro.58.030603.123615  0.491
2003 Sieber SA, Marahiel MA. Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides. Journal of Bacteriology. 185: 7036-43. PMID 14645262 DOI: 10.1128/Jb.185.24.7036-7043.2003  0.573
2003 Duerfahrt T, Doekel S, Sonke T, Quaedflieg PJLM, Marahiel MA. Construction of hybrid peptide synthetases for the production of α‐l‐aspartyl‐l‐phenylalanine, a precursor for the high‐intensity sweetener aspartame Febs Journal. 270: 4555-4563. PMID 14622284 DOI: 10.1046/J.1432-1033.2003.03858.X  0.463
2003 Clugston SL, Sieber SA, Marahiel MA, Walsh CT. Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry. 42: 12095-104. PMID 14556641 DOI: 10.1021/BI035090+  0.625
2003 Finking R, Neumüller A, Solsbacher J, Konz D, Kretzschmar G, Schweitzer M, Krumm T, Marahiel MA. Aminoacyl Adenylate Substrate Analogues for the Inhibition of Adenylation Domains of Nonribosomal Peptide Synthetases Chembiochem. 4: 903-906. PMID 12964169 DOI: 10.1002/Cbic.200300666  0.453
2003 Sieber SA, Walsh CT, Marahiel MA. Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. Journal of the American Chemical Society. 125: 10862-6. PMID 12952465 DOI: 10.1021/Ja0361852  0.708
2003 Ingelfinger D, Göthel SF, Marahiel MA, Reidt U, Ficner R, Lührmann R, Achsel T. Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH Nucleic Acids Research. 31: 4791-4796. PMID 12907720 DOI: 10.1093/Nar/Gkg660  0.319
2003 Schwarzer D, Finking R, Marahiel MA. Nonribosomal peptides: From genes to products Natural Product Reports. 20: 275-287. PMID 12828367 DOI: 10.1039/B111145K  0.477
2003 Linne U, Stein DB, Mootz HD, Marahiel MA. Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry. 42: 5114-24. PMID 12718555 DOI: 10.1021/Bi034223O  0.4
2003 Hicks L, Weinreb P, Konz D, Marahiel MA, Walsh CT, Kelleher NL. Fourier-transform mass spectrometry for detection of thioester-bound intermediates in unfractionated proteolytic mixtures of 80 and 191 kDa portions of Bacitracin A synthetase Analytica Chimica Acta. 496: 217-224. DOI: 10.1016/S0003-2670(03)01001-8  0.531
2002 Doekel S, Eppelmann K, Marahiel MA. Heterologous expression of nonribosomal peptide synthetases in B. subtilis: construction of a bi-functional B subtilis/E coli shuttle vector system. Fems Microbiology Letters. 216: 185-191. PMID 12435501 DOI: 10.1111/J.1574-6968.2002.Tb11434.X  0.416
2002 Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 41: 13350-9. PMID 12416979 DOI: 10.1021/Bi026592A  0.703
2002 Beckering CL, Steil L, Weber MHW, Völker U, Marahiel MA. Genomewide Transcriptional Analysis of the Cold Shock Response in Bacillus subtilis Journal of Bacteriology. 184: 6395-6402. PMID 12399512 DOI: 10.1128/Jb.184.22.6395-6402.2002  0.319
2002 Schwarzer D, Mootz HD, Linne U, Marahiel MA. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proceedings of the National Academy of Sciences of the United States of America. 99: 14083-8. PMID 12384573 DOI: 10.1073/Pnas.212382199  0.517
2002 Mootz HD, Schwarzer D, Marahiel MA. Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem : a European Journal of Chemical Biology. 3: 490-504. PMID 12325005 DOI: 10.1002/1439-7633(20020603)3:6<490::Aid-Cbic490>3.0.Co;2-N  0.502
2002 Sieber SA, Linne U, Hillson NJ, Roche E, Walsh CT, Marahiel MA. Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chemistry & Biology. 9: 997-1008. PMID 12323374 DOI: 10.1016/S1074-5521(02)00214-4  0.709
2002 Mootz HD, Kessler N, Linne U, Eppelmann K, Schwarzer D, Marahiel MA. Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes. Journal of the American Chemical Society. 124: 10980-1. PMID 12224936 DOI: 10.1021/Ja027276M  0.491
2002 May JJ, Kessler N, Marahiel MA, Stubbs MT. Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proceedings of the National Academy of Sciences of the United States of America. 99: 12120-12125. PMID 12221282 DOI: 10.1073/Pnas.182156699  0.48
2002 Weber MHW, Marahiel MA. Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis Philosophical Transactions of the Royal Society B. 357: 895-907. PMID 12171653 DOI: 10.1098/Rstb.2002.1078  0.306
2002 Eppelmann K, Stachelhaus T, Marahiel MA. Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry. 41: 9718-9726. PMID 12135394 DOI: 10.1021/Bi0259406  0.474
2002 Mootz HD, Schörgendorfer K, Marahiel MA. Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. Fems Microbiology Letters. 213: 51-7. PMID 12127488 DOI: 10.1111/J.1574-6968.2002.Tb11285.X  0.42
2002 Luo L, Kohli RM, Onishi M, Linne U, Marahiel MA, Walsh CT. Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry. 41: 9184-96. PMID 12119033 DOI: 10.1021/Bi026047+  0.554
2002 Bruner SD, Weber T, Kohli RM, Schwarzer D, Marahiel MA, Walsh CT, Stubbs MT. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (London, England : 1993). 10: 301-10. PMID 12005429 DOI: 10.1016/S0969-2126(02)00716-5  0.611
2002 Mofid MR, Finking R, Marahiel MA. Recognition of Hybrid Peptidyl Carrier Proteins/Acyl Carrier Proteins in Nonribosomal Peptide Synthetase Modules by the 4′-Phophopantetheinyl Transferases AcpS and Sfp Journal of Biological Chemistry. 277: 17023-17031. PMID 11867633 DOI: 10.1074/Jbc.M200120200  0.458
2002 Bergendahl V, Linne U, Marahiel MA. Mutational analysis of the C‐domain in nonribosomal peptide synthesis Febs Journal. 269: 620-629. PMID 11856321 DOI: 10.1046/J.0014-2956.2001.02691.X  0.484
2002 Weber MHW, Fricke I, Doll N, Marahiel MA. Csdbase: An Interactive Database For Cold Shock Domain Containing Proteins And The Bacterial Cold Shock Response Nucleic Acids Research. 30: 375-378. PMID 11752341 DOI: 10.1093/Nar/30.1.375  0.312
2001 Linne U, Doekel S, Marahiel MA. Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases. Biochemistry. 40: 15824-15834. PMID 11747460 DOI: 10.1021/Bi011595T  0.437
2001 Weber MHW, Beckering CL, Marahiel MA. Complementation of Cold Shock Proteins by Translation Initiation Factor IF1 In Vivo Journal of Bacteriology. 183: 7381-7386. PMID 11717297 DOI: 10.1128/Jb.183.24.7381-7386.2001  0.335
2001 Schwarzer D, Mootz HD, Marahiel MA. Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases. Chemistry & Biology. 8: 997-1010. PMID 11590023 DOI: 10.1016/S1074-5521(01)00068-0  0.494
2001 Mootz HD, Finking R, Marahiel MA. 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. The Journal of Biological Chemistry. 276: 37289-98. PMID 11489886 DOI: 10.1074/Jbc.M103556200  0.445
2001 Eppelmann K, Doekel S, Marahiel MA. Engineered Biosynthesis of the Peptide Antibiotic Bacitracin in the Surrogate Host Bacillus subtilis Journal of Biological Chemistry. 276: 34824-34831. PMID 11448966 DOI: 10.1074/Jbc.M104456200  0.436
2001 Schwarzer D, Marahiel MA. Multimodular biocatalysts for natural product assembly Naturwissenschaften. 88: 93-101. PMID 11402845 DOI: 10.1007/S001140100211  0.481
2001 Kohli RM, Trauger JW, Schwarzer D, Marahiel MA, Walsh CT. Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases. Biochemistry. 40: 7099-108. PMID 11401555 DOI: 10.1021/Bi010036J  0.591
2001 Neumüller AM, Konz D, Marahiel MA. The two-component regulatory system BacRS is associated with bacitracin 'self-resistance' of Bacillus licheniformis ATCC 10716. Febs Journal. 268: 3180-3189. PMID 11389719 DOI: 10.1046/J.1432-1327.2001.02203.X  0.326
2001 Weber T, Marahiel MA. Exploring the domain structure of modular nonribosomal peptide synthetases. Structure. 9. PMID 11342140 DOI: 10.1016/S0969-2126(00)00560-8  0.469
2001 Yazgan A, Ozcengiz G, Marahiel MA. Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin. Biochimica Et Biophysica Acta. 1518: 87-94. PMID 11267663 DOI: 10.1016/S0167-4781(01)00182-8  0.369
2001 Weber MHW, Klein W, Müller L, Niess UM, Marahiel MA. Role of the Bacillus subtilis fatty acid desaturase in membrane adaptation during cold shock. Molecular Microbiology. 39: 1321-1329. PMID 11251847 DOI: 10.1111/J.1365-2958.2001.02322.X  0.302
2001 Doekel S, Marahiel MA. Biosynthesis of Natural Products on Modular Peptide Synthetases Metabolic Engineering. 3: 64-77. PMID 11162233 DOI: 10.1006/Mben.2000.0170  0.453
2001 May JJ, Wendrich TM, Marahiel MA. The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin. The Journal of Biological Chemistry. 276: 7209-17. PMID 11112781 DOI: 10.1074/Jbc.M009140200  0.462
2001 Yazgan A, Özcengiz G, Özcengiz E, Kılınç K, Marahiel MA, Alaeddinoğlu NG. Bacilysin biosynthesis by a partially-purified enzyme fraction from Bacillus subtilis Enzyme and Microbial Technology. 29: 400-406. DOI: 10.1016/S0141-0229(01)00401-X  0.384
2000 Wendrich TM, Beckering CL, Marahiel MA. Characterization of the relA/spoT gene from Bacillus stearothermophilus. Fems Microbiology Letters. 190: 195-201. PMID 11034279 DOI: 10.1111/J.1574-6968.2000.Tb09286.X  0.325
2000 Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT. Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase. Nature. 407: 215-8. PMID 11001063 DOI: 10.1038/35025116  0.564
2000 Klein W, Winkelmann D, Hahn M, Weber T, Marahiel MA. Molecular characterization of the transition state regulator AbrB from Bacillus stearothermophilus. Biochimica Et Biophysica Acta. 1493: 82-90. PMID 10978510 DOI: 10.1016/S0167-4781(00)00171-8  0.39
2000 Linne U, Marahiel MA. Control of directionality in nonribosomal peptide synthesis: role of the condensation domain in preventing misinitiation and timing of epimerization. Biochemistry. 39: 10439-10447. PMID 10956034 DOI: 10.1021/Bi000768W  0.421
2000 Doekel S, Marahiel MA. Dipeptide formation on engineered hybrid peptide synthetases Chemistry & Biology. 7: 373-384. PMID 10873839 DOI: 10.1016/S1074-5521(00)00118-6  0.476
2000 Mootz HD, Schwarzer D, Marahiel MA. Construction of hybrid peptide synthetases by module and domain fusions. Proceedings of the National Academy of Sciences of the United States of America. 97: 5848-53. PMID 10811885 DOI: 10.1073/Pnas.100075897  0.482
2000 Weber T, Baumgartner R, Renner C, Marahiel MA, Holak TA. Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Structure. 8: 407-418. PMID 10801488 DOI: 10.1016/S0969-2126(00)00120-9  0.491
1999 Reuter K, Mofid MR, Marahiel MA, Ficner R. Crystal structure of the surfactin synthetase‐activating enzyme Sfp: a prototype of the 4′‐phosphopantetheinyl transferase superfamily The Embo Journal. 18: 6823-6831. PMID 10581256 DOI: 10.1093/Emboj/18.23.6823  0.464
1999 Mootz HD, Marahiel MA. Design and application of multimodular peptide synthetases. Current Opinion in Biotechnology. 10: 341-8. PMID 10449311 DOI: 10.1016/S0958-1669(99)80062-7  0.457
1999 Stachelhaus T, Mootz HD, Marahiel MA. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chemistry & Biology. 6: 493-505. PMID 10421756 DOI: 10.1016/S1074-5521(99)80082-9  0.486
1999 Göthel SF, Marahiel MA. Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts Cellular and Molecular Life Sciences. 55: 423-436. PMID 10228556 DOI: 10.1007/S000180050299  0.366
1999 Mofid MR, Marahiel MA, Ficner R, Reuter K. Crystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetases. Acta Crystallographica Section D-Biological Crystallography. 55: 1098-1100. PMID 10216318 DOI: 10.1107/S0907444999003674  0.346
1999 Konz D, Marahiel MA. How do peptide synthetases generate structural diversity Chemistry & Biology. 6. PMID 10021423 DOI: 10.1016/S1074-5521(99)80002-7  0.495
1999 Schindler T, Graumann PL, Perl D, Ma S, Schmid FX, Marahiel MA. The family of cold shock proteins of Bacillus subtilis: Stability and dynamics in vitro and in vivo Journal of Biological Chemistry. 274: 3407-3413. PMID 9920884 DOI: 10.1074/Jbc.274.6.3407  0.309
1999 Konz D, Doekel S, Marahiel MA. Molecular and Biochemical Characterization of the Protein Template Controlling Biosynthesis of the Lipopeptide Lichenysin Journal of Bacteriology. 181: 133-140. PMID 9864322 DOI: 10.1128/Jb.181.1.133-140.1999  0.434
1998 Graumann PL, Marahiel MA. A superfamily of proteins that contain the cold-shock domain Trends in Biochemical Sciences. 23: 286-290. PMID 9757828 DOI: 10.1016/S0968-0004(98)01255-9  0.318
1998 Göthel SF, Scholz C, Schmid FX, Marahiel MA. Cyclophilin and trigger factor from Bacillus subtilis catalyze in vitro protein folding and are necessary for viability under starvation conditions Biochemistry. 37: 13392-13399. PMID 9748346 DOI: 10.1021/Bi981253W  0.369
1998 Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA. Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain. The Journal of Biological Chemistry. 273: 22773-81. PMID 9712910 DOI: 10.1074/Jbc.273.35.22773  0.494
1998 Schneider A, Marahiel MA. Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis Archives of Microbiology. 169: 404-410. PMID 9560421 DOI: 10.1007/S002030050590  0.509
1998 Chong PP, Podmore SM, Kieser HM, Redenbach M, Turgay K, Marahiel M, Hopwood DA, Smith CP. Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3(2). Microbiology (Reading, England). 144: 193-199. PMID 9537762 DOI: 10.1099/00221287-144-1-193  0.341
1998 Schindler T, Perl D, Graumann P, Sieber V, Marahiel MA, Schmid FX. Surface-exposed phenylalanines in the RNP1/RNP2 motif stabilize the cold-shock protein CspB from Bacillus subtilis Proteins: Structure, Function and Genetics. 30: 401-406. PMID 9533624 DOI: 10.1002/(Sici)1097-0134(19980301)30:4<401::Aid-Prot7>3.0.Co;2-L  0.349
1998 Schneider A, Stachelhaus T, Marahiel MA. Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping. Molecular Genetics and Genomics. 257: 308-318. PMID 9520265 DOI: 10.1007/S004380050652  0.509
1998 Rajendran N, Rompf A, Marahiel MA, Jahn D. Isolation and characterization of a transposon mutant of Pseudomonas fluorescens AU63 deficient in antifungal activity against Pythium ultimum N. Rajendran Letters in Applied Microbiology. 27: 152-157. DOI: 10.1046/J.1472-765X.1998.T01-1-00412.X  0.322
1997 Marahiel MA, Stachelhaus T, Mootz HD. Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis. Chemical Reviews. 97: 2651-2674. PMID 11851476 DOI: 10.1021/Cr960029E  0.425
1997 Mootz HD, Marahiel MA. Biosynthetic systems for nonribosomal peptide antibiotic assembly. Current Opinion in Chemical Biology. 1: 543-51. PMID 9667890 DOI: 10.1016/S1367-5931(97)80051-8  0.469
1997 Konz D, Klens A, Schörgendorfer K, Marahiel MA. The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases. Chemistry & Biology. 4: 927-937. PMID 9427658 DOI: 10.1016/S1074-5521(97)90301-X  0.49
1997 Wendrich TM, Marahiel MA. Cloning and characterization of a relA/spoT homologue from Bacillus subtilis. Molecular Microbiology. 26: 65-79. PMID 9383190 DOI: 10.1046/J.1365-2958.1997.5511919.X  0.366
1997 Graumann P, Wendrich TM, Weber MH, Schröder K, Marahiel MA. A family of cold shock proteins in Bacillus subtilis is essential for cellular growth and for efficient protein synthesis at optimal and low temperatures. Molecular Microbiology. 25: 741-56. PMID 9379903 DOI: 10.1046/J.1365-2958.1997.5121878.X  0.35
1997 Mootz HD, Marahiel MA. The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. Journal of Bacteriology. 179: 6843-50. PMID 9352938 DOI: 10.1128/Jb.179.21.6843-6850.1997  0.512
1997 Achenbach TV, Göthel SF, Marahiel MA. Histidine 109 in peptidyl-prolyl cis-trans isomerase of Bacillus subtilis plays an important role in catalysis and in cyclosporin A binding. Fems Microbiology Letters. 154: 139-44. PMID 9297832 DOI: 10.1111/J.1574-6968.1997.Tb12635.X  0.309
1997 Marahiel MA. Protein templates for the biosynthesis of peptide antibiotics Chemistry & Biology. 4: 561-567. PMID 9281530 DOI: 10.1016/S1074-5521(97)90242-8  0.504
1997 Conti E, Stachelhaus T, Marahiel MA, Brick P. Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S. The Embo Journal. 16: 4174-83. PMID 9250661 DOI: 10.1093/Emboj/16.14.4174  0.486
1997 Graumann P, Marahiel MA. Effects of heterologous expression of CspB, the major cold shock protein of Bacillus subtilis , on protein synthesis in Escherichia coli Molecular Genetics and Genomics. 253: 745-752. PMID 9079886 DOI: 10.1007/S004380050379  0.323
1997 Göthel SF, Schmid R, Wipat A, Carter NM, Emmerson PT, Harwood CR, Marahiel MA. An internal FK506-binding domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor European Journal of Biochemistry. 244: 59-65. PMID 9063446 DOI: 10.1111/J.1432-1033.1997.00059.X  0.411
1996 Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chemistry & Biology. 3: 923-36. PMID 8939709 DOI: 10.1016/S1074-5521(96)90181-7  0.564
1996 Stachelhaus T, Hüser A, Marahiel MA. Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases. Chemistry & Biology. 3: 913-921. PMID 8939706 DOI: 10.1016/S1074-5521(96)90180-5  0.539
1996 Graumann P, Marahiel MA. Some like it cold: response of microorganisms to cold shock Archives of Microbiology. 166: 293-300. PMID 8929274 DOI: 10.1007/S002030050386  0.32
1996 Graumann P, Schröder K, Schmid R, Marahiel MA. Cold shock stress-induced proteins in Bacillus subtilis. Journal of Bacteriology. 178: 4611-4619. PMID 8755892 DOI: 10.1128/Jb.178.15.4611-4619.1996  0.311
1996 Stachelhaus T, Schneider A, Marahiel MA. Engineered biosynthesis of peptide antibiotics Biochemical Pharmacology. 52: 177-186. PMID 8694841 DOI: 10.1016/0006-2952(96)00111-6  0.498
1996 Göthel SF, Herrler M, Marahiel MA. Peptidyl−Prolyl Cis−Trans Isomerase of Bacillus subtilis: Identification of Residues Involved in Cyclosporin A Affinity and Catalytic Efficiency† Biochemistry. 35: 3636-3640. PMID 8639516 DOI: 10.1021/Bi9520803  0.305
1995 Stachelhaus T, Marahiel MA. Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis Fems Microbiology Letters. 125: 3-14. PMID 7867917 DOI: 10.1111/J.1574-6968.1995.Tb07328.X  0.53
1995 Stachelhaus T, Schneider A, Marahiel MA. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains Science. 269: 69-72. PMID 7604280 DOI: 10.1126/Science.7604280  0.511
1995 Turgay K, Marahiel MA. The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis. Dna Sequence. 5: 283-290. PMID 7579582 DOI: 10.3109/10425179509030982  0.382
1995 Stachelhaus T, Marahiel MA. Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA. Journal of Biological Chemistry. 270: 6163-6169. PMID 7534306 DOI: 10.1074/Jbc.270.11.6163  0.495
1995 Schröder K, Graumann P, Schnuchel A, Holak TA, Marahiel MA. Mutational analysis of the putative nucleic acid‐binding surface of the cold‐shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single‐stranded DNA containing the Y‐box motif Molecular Microbiology. 16: 699-708. PMID 7476164 DOI: 10.1111/J.1365-2958.1995.Tb02431.X  0.396
1994 Graumann P, Marahiel MA. The major cold shock protein of Bacillus subtilis CspB binds with high affinity to the ATTGG‐ and CCAAT sequences in single stranded oligonucleotides Febs Letters. 338: 157-160. PMID 8307174 DOI: 10.1016/0014-5793(94)80355-2  0.325
1994 Gocht M, Marahiel MA. Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis. Journal of Bacteriology. 176: 2654-2662. PMID 8169215 DOI: 10.1128/Jb.176.9.2654-2662.1994  0.416
1994 Herrler M, Bang H, Marahiel MA. Cloning and characterization of ppiB, a Bacillus subtilis gene which encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase. Molecular Microbiology. 11: 1073-1083. PMID 8022278 DOI: 10.1111/J.1365-2958.1994.Tb00384.X  0.378
1994 Borchert S, Stachelhaus T, Marahiel MA. Induction of surfactin production in Bacillus subtilis by gsp, a gene located upstream of the gramicidin S operon in Bacillus brevis. Journal of Bacteriology. 176: 2458-2462. PMID 7512553 DOI: 10.1128/Jb.176.8.2458-2462.1994  0.384
1993 Schnuchel A, Wiltscheck R, Czisch M, Herrler M, Willimsky G, Graumann P, Marahiel MA, Holak TA. Structure in solution of the major cold-shock protein from Bacillus subtilis. Nature. 364: 169-171. PMID 8321289 DOI: 10.1038/364169A0  0.323
1993 Schindelin H, Marahiel MA, Heinemann U. Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein Nature. 364: 164-168. PMID 8321288 DOI: 10.1038/364164A0  0.37
1993 Schröder K, Zuber P, Willimsky G, Wagner B, Marahiel MA. Mapping of the Bacillus subtilis cspB gene and cloning of its homologs in thermophilic, mesophilic and psychrotrophic bacilli Gene. 136: 277-280. PMID 8294017 DOI: 10.1016/0378-1119(93)90479-M  0.331
1992 Marahiel MA. Multidomain enzymes involved in peptide synthesis. Febs Letters. 307: 40-43. PMID 1639192 DOI: 10.1016/0014-5793(92)80898-Q  0.493
1992 Marahiel MA. [Molecular biology and regulatory mechanisms of antibiotic production in Bacillus]. Die Naturwissenschaften. 79: 202-12. PMID 1630495 DOI: 10.1007/BF01227129  0.402
1992 Borchert S, Patil SS, Marahiel MA. Identification of putative multifunctional peptide synthetase genes using highly conserved oligonucleotide sequences derived from known synthetases Fems Microbiology Letters. 92: 175-180. PMID 1601288 DOI: 10.1016/0378-1097(92)90508-L  0.49
1992 Turgay K, Krause M, Marahiel MA. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Molecular Microbiology. 6: 529-546. PMID 1560782 DOI: 10.1111/J.1365-2958.1992.Tb01498.X  0.424
1992 Willimsky G, Bang H, Fischer G, Marahiel MA. Characterization of cspB, a Bacillus subtilis inducible cold shock gene affecting cell viability at low temperatures. Journal of Bacteriology. 174: 6326-6335. PMID 1400185 DOI: 10.1128/Jb.174.20.6326-6335.1992  0.364
1991 Fürbaβ R, Marahiel MA. Mutant analysis of interaction of the Bacillus subtilis transcription regulator AbrB with the antibiotic biosynthesis gene tycA. Febs Letters. 287: 153-156. PMID 1908787 DOI: 10.1016/0014-5793(91)80038-5  0.305
1991 Micka B, Groch N, Heinemann U, Marahiel MA. Molecular cloning, nucleotide sequence, and characterization of the Bacillus subtilis gene encoding the DNA-binding protein HBsu. Journal of Bacteriology. 173: 3191-3198. PMID 1902464 DOI: 10.1128/Jb.173.10.3191-3198.1991  0.355
1989 Mittenhuber G, Weckermann R, Marahiel MA. Gene cluster containing the genes for tyrocidine synthetases 1 and 2 from Bacillus brevis: evidence for an operon. Journal of Bacteriology. 171: 4881-4887. PMID 2768192 DOI: 10.1128/Jb.171.9.4881-4887.1989  0.301
1989 Robertson JB, Gocht M, Marahiel MA, Zuber P. AbrB, a regulator of gene expression in Bacillus, interacts with the transcription initiation regions of a sporulation gene and an antibiotic biosynthesis gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 8457-61. PMID 2554317 DOI: 10.1073/Pnas.86.21.8457  0.322
1989 Krätzschmar J, Krause M, Marahiel MA. Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases. Journal of Bacteriology. 171: 5422-5429. PMID 2477357 DOI: 10.1128/Jb.171.10.5422-5429.1989  0.338
1988 Krause M, Marahiel MA. Organization of the biosynthesis genes for the peptide antibiotic gramicidin S. Journal of Bacteriology. 170: 4669-4674. PMID 2459107 DOI: 10.1128/Jb.170.10.4669-4674.1988  0.355
1986 Marahiel MA, Krause M, Skarpeid HJ. Cloning of the tyrocidine synthetase 1 gene from Bacillus brevis and its expression in Escherichia coli. Molecular & General Genetics : Mgg. 201: 231-6. PMID 3003526 DOI: 10.1007/Bf00425664  0.327
1985 Krause M, Marahiel MA, Döhren Hv, Kleinkauf H. Molecular cloning of an ornithine-activating fragment of the gramicidin S synthetase 2 gene from Bacillus brevis and its expression in Escherichia coli. Journal of Bacteriology. 162: 1120-1125. PMID 3888956 DOI: 10.1128/Jb.162.3.1120-1125.1985  0.354
1984 Modest B, Marahiel MA, Pschorn W, Ristow H. Peptide antibiotics and sporulation: induction of sporulation in asporogenous and peptide-negative mutants of Bacillus brevis. Microbiology. 130: 747-755. PMID 6204006 DOI: 10.1099/00221287-130-4-747  0.41
1982 Danders W, Marahiel MA, Krause M, Kosui N, Kato T, Izumiya N, Kleinkauf H. Antibacterial action of gramicidin S and tyrocidines in relation to active transport, in vitro transcription, and spore outgrowth. Antimicrobial Agents and Chemotherapy. 22: 785-790. PMID 6185087 DOI: 10.1128/Aac.22.5.785  0.378
1982 Kurotsu T, Marahiel MA, Müller KD, Kleinkauf H. Characterization of an intracellular serine protease from sporulating cells of Bacillus brevis. Journal of Bacteriology. 151: 1466-72. PMID 6179927 DOI: 10.1128/JB.151.3.1466-1472.1982  0.32
1977 Marahiel MA, Imam G, Nelson P, Pieniaźek NJ, Stepień PP, Küntzel H. Identification of an intramitochondrially synthesized proteolipid associated with the mitochondrial ATPase complex as the product of a mitochondrial gene determining oligomycin resistance in Aspergillus nidulans. Febs Journal. 76: 345-354. PMID 142636 DOI: 10.1111/J.1432-1033.1977.Tb11602.X  0.645
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