We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Holden R. Higginbotham is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2006 — 2007 |
Higginbotham, Holden R |
F31Activity Code Description:
To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Polarity Establishment During Neuronal Migration @ University of California San Diego
[unreadable] DESCRIPTION (provided by applicant): The signaling pathways contributing to the polarized cytoskeleton of migrating neurons are not well understood. It is generally accepted that guidance cues play critical roles in establishing migration routes and axonal trajectories, but understanding how these factors signal to changes in the neuronal cytoskeleton remains an important topic. In my preliminary data, I have adopted an in vitro migration assay using primary neurons to model responses to these cellular cues, where cells undergo acute repolarization in response to a chemorepellent. I identified four stages that constitute this repolarization event. This research proposes to identify the roles of likely key regulators of these events: Rho-family GTPases Cdc42, Rac1, and RhoA, their effector protein IQGAP1, and +TIP microtubule (MT) tracking proteins EB1, CLIP-170 and APC. The spatio- temporal regulation and requirement of these molecules will be investigated using live-cell microscopy, fluorescently-tagged proteins, and genetic manipulation of gene expression and protein activity. These studies will provide mechanistic insight into cell polarity in migration, adding understanding to disorders that result from defects in neuronal migration including epilepsy, lissencephaly, and mental retardation. [unreadable] [unreadable]
|
1 |