Regina A. Mangieri, Ph. D. - US grants

Affiliations:

College of Pharmacy, Division of Pharm/Tox

University of Texas at Austin, Austin, Texas, U.S.A.

Area:

endocannabinoids, mood disorders, substance use disorders, synaptic plasticity

Website:

http://sites.utexas.edu/mangieri/

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High-probability grants

According to our matching algorithm, Regina A. Mangieri is the likely recipient of the following grants.

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Years	Recipients	Code	Title / Keywords	Matching score
2009 — 2010	Mangieri, Regina A.	F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas.	The Role of the Endogenous Cannabinoid System in Ethanol Self-Administration @ University of Texas, Austin DESCRIPTION (provided by applicant): The general objective of this project is to explore the neurobiological mechanisms responsible for the escalation and maintenance of ethanol self-administration. Current theories of addiction posit that long-term ethanol self-administration becomes a habit-based, rather that goal-oriented, behavior. Neuroplasticity in the dorsolateral striatum is thought to be necessary for the expression of habitual behavior, and recent research implicates the endocannabinoid system in both habit formation and in several forms of striatal plasticity. Thus, the overarching hypothesis of this proposal is that the maintenance of long-term ethanol self-administration is a habit-based behavior mediated, at least in part, by endocannabinoid signaling in the dorsolateral striatum. This hypothesis will be tested in the two specific aims of the present application. The first aim will measure the effect of operant ethanol self-administration by Long Evans rats on extracellular levels of the two endocannabinoids anandamide and 2-AG, as measured by in vivo microdialysis, in the dorsolateral striatum. The second aim will examine the involvement of the cannabinoid CB1 receptor during the expression of habitual operant ethanol self-administration in Long Evans rats. After establishing self- administration of ethanol, rats will receive infusions of the CB1 receptor antagonist rimonabant into the dorsolateral striatum to determine the involvement of these receptors in self-administration behavior. Together, the results of these experiments should increase the understanding of the role of the endocannabinoid system in habitual ethanol self-administration, and contribute new information regarding the mechanisms that underlie the maintenance of habitual self-administration of alcohol. Public health relevance: The present study aims to investigate neurobiological mechanisms underlying the development and maintenance of behaviors involved in alcohol addiction. The information gained from this research will lead to a better understanding the brain changes that occur as chronic alcohol use develops, and could be used to develop more effective treatments for alcohol addiction. Show summary Hide summary	1
2019 — 2020	Mangieri, Regina A.	U24Activity Code Description: To support research projects contributing to improvement of the capability of resources to serve biomedical research.	Target Validation Electrophysiology Core @ University of Texas, Austin PROJECT SUMMARY/ABSTRACT This Integrative Neuroscience Initiative on Alcoholism (INIA-Neuroimmune [INIA-N]) consortium application is for a U24 Research Resource that will act as a service core to provide electrophysiological evaluation of targets identified or developed by INIA-N investigators. The guiding hypothesis of INIA-N is that genetic differences and neuroadaptations in immune-related pathways contribute to the vulnerability to excessive alcohol consumption. In addition to validating neuroimmune signaling pathways already identified during the prior funding period, this consortium will use genomic datasets and computational approaches to predict novel compounds that may be efficacious in reducing excessive alcohol consumption. This core resource will provide essential services to INIA-N investigators by performing studies that examine the cellular electrophysiological functions of brain immune signaling systems and their causal or therapeutic role(s) in excessive alcohol consumption. These studies will be divided among three major subgroups of INIA-N target identification and investigation. In Specific Aim 1, novel INIA-N compounds that are efficacious in reducing excessive alcohol consumption will be evaluated. In Specific Aim 2, the focus will be on genetic targets, of which the majority will be long non-coding RNAs shown to influence drinking. Specific Aim 3 will focus on studies in animal models of hereditary excessive drinking. Electrophysiological experiments, designed in collaboration with the relevant INIA-N investigators, will use new technologies to study neural circuits involved in excessive drinking, and, in cases of wholly novel targets, will employ an unbiased approach of measuring basic membrane properties along with excitatory and/or inhibitory synaptic transmission to screen for mechanisms of action in mesolimbic brain structures. The results of these studies will provide basic information on the role of brain neuroimmune systems in excessive ethanol consumption and help prioritize novel targets for further development. Show summary Hide summary	1