Kenneth P. Wright - US grants
Affiliations: | University of Colorado, Boulder, Boulder, CO, United States |
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Kenneth P. Wright is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
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| 2003 — 2004 | Wright, Kenneth P | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Effect of Sleep Deprivation On Inflammatory Markers @ University of Colorado At Boulder DESCRIPTION (provided by applicant): Heart disease, vascular disease and respiratory sleep disturbance are common and complex disorders with interactions among the cardiovascular, immune, neuroendocrine, sleep and circadian systems. Because inflammation in response to acute and chronic stress responsible for tissue damage associated with disease, recent efforts to understand mechanisms underlying these disorders have lead to studies that investigated inflammatory markers. These research efforts have revealed that high plasma levels of several novel inflammatory markers-cell adhesion molecules and pro-inflammatory cytokines-predict cardiovascular morbidity and mortality. High plasma levels of these markers are also reported to be associated with the severity of sleep apnea. A variety of stressors have been reported to initiate the inflammatory response, however, whether the stress of sleep deprivation also produces higher levels of these novel inflammatory markers is unknown. The current grant application takes an integrative physiological approach to understanding health consequences of sleep deprivation by forming new collaborations between experts in vascular physiology, neuronimmunophysiology, neuroendocrinology and sleep and circadian physiology. We are requesting funds to analyze existing biological specimens that were collected under controlled laboratory conditions from healthy women and men who underwent baseline sleep and wakefulness recording and 40 hours of total sleep deprivation. We propose to test the following specific hypothesis: 0 that acute total sleep deprivation will increase circulating levels of proinflammatory cell adhesion molecules; and ii) that acute total sleep deprivation will increase circulating levels of pro-inflammatory cytokines. We also propose to measure stress hormones to determine the relationship between changes in inflammatory cell adhesion molecules, cytokines and stress hormones during sleep deprivation and during baseline sleep. Because sleep loss is an independent risk factor for heart disease and chronic sleep loss is a consequence of sleep apnea, the results of the proposed study could have important implications for understanding the molecular mechanisms underlying these disorders and their association with sleep loss. This work could also have a significant impact on our understanding of the health consequences of sleep loss, which would have implications for public health and safety. |
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| 2004 | Wright, Kenneth P | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Effects of Chronic Sleep Loss On Daytime Cognitive @ University of Colorado Denver performance; neuropsychology; cognition; sleep disorders; public health; clinical research; human subject; |
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| 2007 — 2008 | Wright, Kenneth P | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
The Metabolic Cost of Extended Wakefulness @ University of Colorado Denver CO2; CRISP; Carbon Dioxide; Carbonic Anhydride; Computer Retrieval of Information on Scientific Projects Database; Food Energy; Funding; Grant; Health; Institution; Investigators; Life; Measures; Metabolic; NIH; National Institutes of Health; National Institutes of Health (U.S.); O element; O2 element; Oxygen; Research; Research Personnel; Research Resources; Researchers; Resources; Sleep; Source; United States National Institutes of Health; Wakefulness; Wakefulnesses; awake; cost; day; improved |
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| 2009 — 2010 | Wright, Kenneth P | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Health and Safety Consequences of Sleep Loss @ University of Colorado Findings from survey studies indicate that the average American adult obtains an inadequate amount of sleep. Chronic sleep loss contributes to accidents and related deaths, poor job/school performance and poor health. In regards to health, short sleep duration has been hypothesized to contribute to the development of obesity however, the effects of sleep loss on mechanisms contributing to obesity are poorly understood. We propose to study 24 hour energy expenditure and mediators of energy balance during sleep loss to better understand the increased risk of obesity associated with sleep loss. The specific aims of this proposal are to determine the influence of chronic sleep loss on cognitive function, metabolism, and energy balance in humans tested in an 11 day inpatient CTRC study. The proposed research addresses several themes outlined in the NIH PA NUMBER: PA-07-140 by testing the following specific hypotheses: i) chronic sleep loss will impair mood. alertness and performance levels;ii) chronic sleep loss will impair glucose tolerance, an effect related to decreases in insulin action and increases in sympathetic nervous system (SNS) activity;iii) chronic sleep loss will lead to positive energy balance promoting weight gain. We will also examine biological mediators associated with expected alterations in 24 h energy balance during sleep loss. The proposed project addresses several of the highest recommendations for research in the 2003 NIH National Center on Sleep Disorders Research Plan including i) to enhance our understanding of the impact of reduced or restricted sleep on behavior, and neurobiologic and physiologic functions;ii) to delineate processes involved in and the mechanisms underlying the influence of chronic sleep deprivation on non-neural systems;iii) to delineate the effects of sleep loss on behaviors that diminish safety. |
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| 2011 — 2014 | Wright, Kenneth P | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Metabolic and Cognitive Consequences of Sleep Loss @ University of Colorado DESCRIPTION (provided by applicant): Chronic sleep loss affects millions of Americans. Short sleep schedules are associated with increased risk of weight gain, obesity, diabetes, the metabolic syndrome, and accidents. It is unknown if the common and self- selected behavior of weekend recovery sleep helps to protect against the health and safety effects of sleep loss. Furthermore, we do not fully understand the physiological and behavioral mechanisms that contribute to the negative health effects associated with sleep loss nor do we fully understand the time course of how quickly changes in some of these physiological systems occur. Therefore, we have designed a randomized 14-16 day in- lab Clinical and Translational Research Center (CTRC) study that uses whole room calorimetric, hyperinsulinemic/euglycemic clamps and safety sensitive cognitive tests to address these critical deficiencies in our knowledge. The stage for the proposed research was set by our NIH ARRA grant Heath and Safety Consequences of Sleep Loss and our proposed project is a continuation of this research effort. The project addresses several themes outlined in NIH PA NUMBER: PA-10-152 Diet Composition and Energy Balance by testing the following specific hypotheses: i) chronic sleep loss will lead to positive energy balance-a physiological state contributing to weight gain and weekend recovery sleep will restore energy balance to near baseline levels; ii) chronic sleep loss will impair insulin sensitivity and weekend recovery sleep will restore insulin sensitivity to near baseline levels; iii) chronic sleep loss will impair cognition and weekend recovery sleep will restore performance levels to near baseline. This research effort is responsive to PA-10-152 by assessing effects of sleep deprivation on macronutrient consumption and effects of dietary composition on physiological responses to sleep loss. The proposed project also meets the following highest recommendations for future research in the NIH National Center on Sleep Disorders Research (NCSDR) 2003 plan: i) enhance understanding of the impact of reduced or restricted sleep on behavior, and neurobiologic and physiologic functions; and ii) mechanisms underlying aspects of chronic sleep deprivation on non-neural systems. |
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| 2012 — 2013 | Wright, Kenneth P | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Circadian Misalignment and Energy Metabolism @ University of Colorado DESCRIPTION (provided by applicant): The interplay of circadian timing and metabolic physiology represents a new frontier in biomedical research. Research on weight gain in humans has focused primarily on macronutrient intake and energy expenditure, the latter predominantly through physical activity, to understand and treat overweight and obesity. Emerging evidence from animal models indicates that circadian physiology impacts weight gain, including the observation of obesity in clock gene mutants and most recently the finding that food intake restricted to the habitual sleep time of mice leads to weight gain as compared to the same amount of food intake during the normal wake episode. We propose to determine if findings from these mouse models translate to humans. To do so, we have designed an exploratory Clinical and Translational Research Center (CTRC) study that uses whole room calorimetry to determine how restricting the majority of food intake to the biological night impacts energy metabolism in humans. Eating at night is common in work schedules with long work hours and with work operations during the nighttime hours (e.g., health care, emergency response, security personnel) and in circadian sleep disorders including, but not limited to, shift work and jet lag disorder. Night eating disorders are also newly recognized conditions that may contribute to obesity. The project addresses several themes outlined in NIH PA NUMBER: 09-124 Exploratory/Developmental Clinical Research Grants in Obesity by testing the following specific hypothesis: i) circadian misalignment will lead to reduced fat oxidation-a physiological state that could contribute to weight gain. This research effort is responsive to PA-09-124 as it will assess how a behavioral phenotype of eating at night increases risk for obesity and will contribute to identification of this behavior as a modifiable determinant of overweight and obesity. |
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| 2016 — 2017 | Reisdorph, Nichole A Wright, Kenneth P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Biomarkers of Insufficient Sleep and Sleepiness @ University of Colorado ? DESCRIPTION (provided by applicant): Sleep and wakefulness disorders impact 50 to 70 million Americans and insufficient sleep is epidemic with over 50% of Americans reporting less than 7 hours of sleep per night. Health problems associated with insufficient sleep include inflammation, depression and anxiety, diabetes, stress, drug abuse, poor quality of life, obesity, and fatigue related accidents on the job/while driving. While the contribution of sleep to overall health, well-being, and public safety is recognized, no established clinical biomarkers of sleep deficiency exist. Such biomarkers would have utility as road-side biomarkers of sleepiness (e.g., drowsy driving), monitoring on the job fatigue/fitness for duty (e.g., transportation, military ops health care), monitoring sleep health, as well as for clinical diagnostics and measures of clinical treatment outcomes. Thus, we designed a controlled laboratory insufficient sleep protocol utilizing metabolomics to identify biomarkers of insufficient sleep. Preliminary metabolomics data from our NIH Administrative Supplement awarded to our existing R01 Metabolic and Cognitive Consequences of Sleep Loss set the stage for this proposal and facilitated our proposed discovery and targeted approaches. The current proposal is responsive to key goals of the 2014 Joint Task Force of the Sleep Research Society and American Academy of Sleep Medicine report. We propose to identify changes in metabolites that consistently occur during insufficient sleep. We will also target metabolites identified by our previous research efforts as potential biomarkers. As an exploratory outcome we will examine associated changes in metabolites and cognitive performance during insufficient sleep. These proposed outcomes support the NIH Precision Medicine Initiative and the 2011 NIH Sleep Disorders Research Plan to identify biomarkers of sleep deficiency and enabling sleep and circadian research training in cross-cutting domains to accelerate the pace of discovery and translation. |
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| 2017 — 2020 | Desouza, Christopher A [⬀] Stauffer, Brian L Wright, Kenneth P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Sleep and Blood Pressure-Related Endothelial Abnormalities @ University of Colorado PROJECT SUMMARY/ABSTRACT Aside from age, elevated blood pressure is the most predominant cardiovascular disease risk factor worldwide. In the United States it is estimated that ~60% of the adult population have elevated blood pressure in either the prehypertensive (120-139/80-89 mmHg) or hypertensive (>140/90 mmHg) range. Both prehypertension (particularly systolic BP >130 mmHg) and hypertension are associated with increased risk for myocardial infarction, heart failure, stroke and vascular disease. Endothelial dysfunction is a major factor underlying the increased risk of vascular events with elevated blood pressure. In addition, insufficient nightly sleep (<7 hr/night) and poor sleep quality have been linked not only to the etiology of elevated blood pressure but are also a prevalent, often ignored, comorbidity. Indeed, short sleep duration and/or poor sleep quality is now considered to be a plausible risk factor for elevated blood pressure and a harbinger of increased cardiovascular risk. A high prevalence of insufficient nightly sleep has been reported in hypertensive adults. Importantly, habitual sleep duration of less than 7 hr/night is independently associated with an increased risk of stroke and coronary artery disease. The influence of insufficient sleep on vascular endothelial function in adults with elevated blood pressure is unknown. Moreover, given the emerging relation between sleep duration and quality and blood pressure, sleep represents an important, and currently neglected, therapeutic target for improving vascular health and, in turn, reducing cardiovascular risk in adults with elevated blood pressure. The present proposal will test the following hypotheses: 1) that chronic insufficient sleep is associated with diminished endothelium- dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in adults with elevated blood pressure. Furthermore, the postulated diminishment in endothelial vasodilator and fibrinolytic function with insufficient sleep will be due, at least in part, to increased oxidative stress; and 2) increasing sleep duration and improving sleep quality (utilizing individualized targeted sleep interventions) will increase both endothelium-dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in adults with elevated blood pressure. Increases in endothelial vasodilator and fibrinolytic function will be due, at least in part, to reduced oxidative stress. To test these hypotheses, 124 middle-aged adults with elevated blood pressure (>130/80 mmHg) will be studied. Endothelial vasodilator and fibrinolytic function will be assessed, in vivo, using an isolated forearm model. The proposed study will provide new and clinically important information regarding the influence of insufficient sleep on vascular endothelial function in adults with elevated blood pressure. Moreover, determining the possible cardioprotective effects of improving sleep and circadian physiology on vascular endothelial vasodilator and fibrinolytic function in adults with elevated blood pressure is clinically innovative, novel and critical to the development of optimal strategies (both primary and adjunctive) to mitigate blood pressure-related cardiovascular risk. |
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| 2020 — 2021 | Wright, Kenneth P | T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Transdisciplinary Training in Sleep and Circadian Rhythms @ University of Colorado ABSTRACT The primary aim of this new University of Colorado transdisciplinary training program is to prepare outstanding pre-(PhD) and post-(PhD, MD/PhD, MD) doctoral fellows for science careers that address cutting-edge basic and clinical research questions that represent the future of biomedical research. The training program will foster transdisciplinary research with state-of-the-art technologies and methods used by participating faculty laboratories, and will evaluate and enhance the mentoring skills of early career faculty. The program is novel in that it exposes trainees and faculty from diverse biomedical research backgrounds to collaborative sleep and circadian science. Similarly, current sleep and circadian trainees and expert faculty benefit from meaningful interactions with investigators from different research backgrounds, particularly those from biomedical research areas that are of high importance to the NIH/NHLBI. The research training activities of the 22 participating faculty emphasize transdisciplinary training in sleep and circadian physiology with research programs focused on cardiovascular, genetics/genomics, metabolomics, proteomics, biomarker development, bioinformatics, biostatistics, epidemiology, stress physiology, immunology, endocrinology, metabolism, obesity, diabetes, neuroscience, pediatrics, development, aging, psychiatry, and pulmonary and behavioral sleep medicine. Because our goal is to provide transdisciplinary and translational research career training, major program components of this T32 include the Department of Integrative Physiology, the Department of Psychology and Neuroscience, and the Institute for Behavioral Genetics at University of Colorado Boulder, and multiple clinical departments and divisions at University of Colorado School of Medicine Anschutz Medical Campus. The existing fruitful and collaborative environment is a strength of this training grant. Of the existing T32s at the University of Colorado, this would be the only one dedicated to transdisciplinary sleep and circadian science. Also, it would become the first sleep and circadian T32 in the Western United States. The specific aims of the training program are to recruit, select and retain outstanding trainees; promote inclusive excellence; provide high quality training, educational, and career development experiences to prepare trainees for research-intensive and research-related careers; shape tomorrow?s scientific leaders; foster rigorous and collaborative sleep and circadian science; ensure successful progress of trainees toward predetermined milestones defined in Individual Development Plans; enhance the mentoring skills of faculty through a formal mentoring training plan; ensure conscientious program evaluation; and expand the number of investigators conducting transdisciplinary sleep and circadian science. We request support for one pre-doctoral and one post-doctoral trainee in year 1, and two pre-doctoral and two post-doctoral trainees in years 2-5. |
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