Area:
Gustation, reward pathways, plasticity
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High-probability grants
According to our matching algorithm, Shashank Tandon is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2019 |
Tandon, Shashank |
R03Activity Code Description:
To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Role of Differences in Lateral Habenula Activity During Initial Ethanol Use in Determining Future Ethanol Consumption
Abstract Differences in sensitivity to ethanol?s aversive effects during initial use are an important contributing risk factor for ethanol abuse in future. Individuals who show a low aversive response e.g. slurring of speech and motor incoordination during initial ethanol use are more at risk to start excessive drinking in future and to develop alcohol use disorder (AUD). Lateral Habenula (LHb) is a brain area that is involved in learning through aversive outcomes and thus ethanol induced LHb activity during initial ethanol use can likely play a role in modulating ethanol intake. Furthermore, there is a strong correlation between negative emotional state and subsequent alcohol intake and thus development of AUD over time. Also, in both human and rodent studies, negative emotional state is associated with higher LHb activity. These result suggests that both baseline and ethanol induced LHb activity could contribute to modulation of future ethanol consumption. Wistar rats and selectively bred alcohol-preferring (P) show significant differences in average ethanol intake and P rats are a validated model for AUD. However, until now, the neural circuitry underlying these differences in ethanol consumption over time in the two groups of rats and the critical role of the LHb in this circuitry specifically has not been determined. Thus we will test whether differences in baseline LHb firing and LHb neuronal responses during early ethanol use determine future ethanol intake in ethanol naive P and Wistar rats. For Aim 1, we will record the baseline LHb firing rate and the Ultrasonic vocalizations (USVs) in male and female ethanol naïve P and Wistar rats. We expect that P rats will show higher baseline LHb firing rates and more counts of 22-28 KHz USVs (aversive) calls as compared to Wistar rats. For Aim 2, we will record the LHb firing rate and the USVs following ethanol injection in ethanol naïve P and Wistar rats. We expect that P rats will show lower LHb firing following ethanol injection and fewer counts of aversive calls as compared to Wistar rats. Rats in both Aim 1 and 2 will then undergo an intermittent access 2-bottle choice paradigm for seven weeks to measure average and end point voluntary ethanol consumption.
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