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High-probability grants
According to our matching algorithm, Eric M. Lasater is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 2002 |
Lasater, Eric M [⬀] |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Membrane Properties of Vertebrate Retinal Neurons
Neurons of the vertebrate retina will be studied in a preparation of isolated cells maintained in cell culture. The overall goal of the project is to determine how the individual neurons of the vertebrate retina process visual information. The techniques of whole-cell and single-channel voltage-clamp will be used to characterize the voltage and neurotransmitter gated ionic currents intrinsic to the membranes of retinal horizontal, bipolar and ganglion cells. Specifically, the neurons will be voltage- clamped and potassium and calcium currents investigated. I-V characteristics will be studied as well as gating, kinetics of currents, activation and inactivation. Single channel recordings will be carried out to investigate the properties of retinal potassium and calcium channels and to make comparisons with those types of channels found in the CNS. Putative photoreceptor neurotransmitters such as glutamate, kainate and quisqualate will be studied in an effort to determine how these transmitters modulate the membrane properties of horizontal and bipolar cells. For similar reasons, the actions of putative amacrine cell transmitters on ganglion cells will be studied. The modulation of electrical coupling between horizontal cells will also be investigated using these techniques. The use of isolated retinal neurons is a powerful tool which allows the study of the physiology of retinal cells outside of the retinal network. Problems such as the state of light adaptation and indirect effects of neurotransmitters due to a multiplicity of inputs are not present. As a result, information can be gathered which was previously inaccessible. This project will provide knowledge about the basic properties of ionic channels in retinal cell membranes and how these channels are modulated to influence the signalling capabilities of the cell. This will lead to a better comprehension of how retinal neurons operate, as well as an increased understanding of how the nervous system in general processes information.
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1 |
1995 — 1998 |
Lasater, Eric M [⬀] |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Membrane Properties of Retinal Neurons
DESCRIPTION: The long term goal of this application is to understand better how the retina processes visual information. During this grant period whole- cell and single-channel voltage-clamp techniques, calcium imaging and electro- physiological recordings will be used to study the function of particular neurons and how their function is controlled and modulated. The studies will be carried out on isolated cells in culture and retinal slices from the white bass and turtle. Specifically the studies will: 1) learn how the neuromodulator dopamine regulates calcium influx into white bass horizontal cells and study the impact of this regulation on the cells' response properties; 2) characterize the calcium current of white bass bipolar cells and learn if dopamine or GABA can modulate calcium entry into these cells, and learn the effect any modulation might have on the cell's response properties and subsequently synaptic transmission; and 3) characterize the different GABA receptors found on turtle retinal ganglion cells and study their role in ganglion cell response formation. These studies are important because they will lead us to a better understanding how retinal neurons, and neurons in general, function. Also, to understand and treat retinal disease, an understanding of healthy retinal function is necessary.
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1 |